chr6:31543342:> Detail (hg19)

Information

Genome

Assembly Position
hg19 chr6:31,543,342-31,546,113
hg38 chr6:31,575,565-31,578,336 

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.120 Carcinoma, Transitional Cell NA BeFree,CTD_human Detail
0.023 Cardiomyopathy, Dilated NA BeFree,GAD,LHGDN Detail
0.044 Cardiovascular Diseases As this response was inhibited by a blocking anti-TNFα antibody, drug targeting ... BeFree,GAD,LHGDN 25090652 Detail
0.044 Cardiovascular Diseases Experimental evidence support soluble receptors for tumor necrosis factor alpha ... BeFree,GAD,LHGDN 25255422 Detail
0.044 Cardiovascular Diseases No significant relation of the TNF-α -238G/A polymorphism with CVD was found; ho... BeFree,GAD,LHGDN 25274950 Detail
0.044 Cardiovascular Diseases The tumor necrosis factor-alpha (TNF-a) and interleukin (IL)-6 gene polymorphism... BeFree,GAD,LHGDN 25827698 Detail
<0.001 Carotid Artery Diseases NA BeFree Detail
0.039 celiac disease TNFA promoter haplotypes associate with CD independently from HLA. BeFree,GAD,LHGDN 25915602 Detail
0.002 Chronic Kidney Diseases The Chi-square test, multivariable logistic regression analysis with adjustment ... BeFree 19424605 Detail
0.001 CNS disorder NA BeFree Detail
<0.001 Central Nervous System Infection NA BeFree Detail
0.003 intracranial aneurysm NA BeFree,GAD Detail
0.002 intracranial arteriosclerosis NA GAD Detail
0.002 Intracranial Arteriovenous Malformation NA GAD Detail
0.014 cerebral infarction NA BeFree,GAD,LHGDN Detail
0.132 brain ischemia TNF-related apoptosis inducing ligand (TRAIL), a member of the TNF superfamily r... BeFree,CTD_human,GAD 25032854 Detail
0.080 Transient ischemic attack NA BeFree,RGD Detail
0.010 cerebral palsy NA BeFree,GAD,LHGDN Detail
0.005 Cerebrovascular Disorders NA GAD Detail
0.007 Malignant tumor of cervix Re-expression of HPV16 E2 in SiHa (human cervical cancer) cells potentiates NF-κ... BeFree 25572145 Detail
0.007 Malignant tumor of cervix TNF-α -308 G/A as a risk marker of cervical cancer progression in the Polish pop... BeFree 25614219 Detail
0.002 Uterine Cervical Incompetence NA GAD Detail
0.024 Uterine Cervical Neoplasm NA GAD,LHGDN Detail
0.005 Chagas Cardiomyopathy NA BeFree,GAD Detail
<0.001 Charcot-Marie-Tooth disease NA BeFree Detail
0.001 cherubism These findings suggest that the SH3BP2 cherubism mutation can cause jawbone dest... BeFree 24916406 Detail
0.126 Chlamydia Infections NA BeFree,CTD_human,GAD Detail
0.004 Primary biliary cirrhosis A genome-wide association study (GWAS) identified tumor necrosis factor superfam... BeFree 25899471 Detail
0.005 Cholangitis, Sclerosing NA BeFree,GAD Detail
<0.001 cholelithiasis NA BeFree Detail
0.120 cholestasis NA BeFree,CTD_human Detail
<0.001 cholesteatoma This study suggested that persistent expression of extracellular HMGB-1 and DNA ... BeFree 25416861 Detail
0.004 chondrosarcoma NA BeFree,LHGDN Detail
0.002 Chorea NA GAD Detail
0.017 chorioamnionitis NA GAD,LHGDN Detail
<0.001 choriocarcinoma In contrast, HERV env expressing choriocarcinoma cell lines suppressed T-cell pr... BeFree 25752285 Detail
0.003 chorioretinitis NA BeFree,GAD Detail
0.002 hemophilia B NA GAD Detail
0.003 clonorchiasis NA BeFree,GAD Detail
0.133 colitis In mice, IL-19 up-regulates TNFα and IL-6 expression and its deficiency increase... BeFree,CTD_human,LHGDN 24718601 Detail
0.133 colitis We found the BAG-1 isoform BAG-1M upregulated threefold in human Caco-2 cells fo... BeFree,CTD_human,LHGDN 24876225 Detail
0.133 colitis Monocytes/macrophages are major producers of tumor necrosis factor-α (TNF-α), a ... BeFree,CTD_human,LHGDN 24938744 Detail
0.133 colitis In an experimental model of colitis, mucosal VDR expression is reduced over time... BeFree,CTD_human,LHGDN 25192497 Detail
0.133 colitis SEW2871 treatment attenuated established colitis associated with decreased CD4+ ... BeFree,CTD_human,LHGDN 25588868 Detail
0.133 colitis Here we use wildtype (WT) and mice lacking Tnf (Tnf-/-) in an acute TNBS colitis... BeFree,CTD_human,LHGDN 25775453 Detail
0.133 colitis Inhibition of the tumor necrosis factor (TNF)-like weak inducer of apoptosis (TW... BeFree,CTD_human,LHGDN 26012567 Detail
0.133 colitis Our data suggested that SGK1 may protect IECs in colitis from tumor necrosis fac... BeFree,CTD_human,LHGDN 26034353 Detail
<0.001 Colonic Diseases In addition, IL-10 KO mice receiving Bifico treatment had reduced mucosal secret... BeFree 24782616 Detail
0.123 Colonic Neoplasms NA BeFree,CTD_human,LHGDN Detail
0.011 colorectal carcinoma Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to ... BeFree 25174402 Detail
0.011 colorectal carcinoma Consistently, we found that, in human colorectal cancer tissues, high levels of ... BeFree 25306394 Detail
0.011 colorectal carcinoma Previously, we demonstrated that tumor necrosis factor (TNF) induced DAPK-mediat... BeFree 25380824 Detail
0.011 colorectal carcinoma Increased expression of tumor necrosis factor-α is associated with advanced colo... BeFree 25561807 Detail
0.132 Colorectal Neoplasms NA BeFree,CTD_human,GAD,LHGDN Detail
0.007 common cold NA GAD Detail
0.002 common variable immunodeficiency NA BeFree Detail
0.003 Compartment syndromes NA LHGDN Detail
<0.001 Condylomata Acuminata NA BeFree Detail
<0.001 conjunctivitis NA BeFree Detail
0.003 Connective Tissue Diseases NA BeFree,GAD Detail
0.002 Constipation NA GAD Detail
<0.001 Constitutional Symptom NA BeFree Detail
0.006 Febrile Convulsions NA BeFree,GAD Detail
<0.001 corneal ulcer NA BeFree Detail
0.003 coronary aneurysm NA BeFree,GAD Detail
0.016 Coronary Arteriosclerosis Diagnostic potential of differentially expressed Homer1, IL-1β, and TNF-α in cor... BeFree,GAD 25551602 Detail
0.032 Coronary heart disease Diagnostic potential of differentially expressed Homer1, IL-1β, and TNF-α in cor... BeFree,GAD,LHGDN 25551602 Detail
0.002 Coronary Vessel Anomalies NA GAD Detail
0.002 cowpox NA BeFree Detail
<0.001 craniosynostosis NA BeFree Detail
0.003 congenital hypothyroidism NA BeFree,LHGDN Detail
<0.001 cryoglobulinemia NA BeFree Detail
<0.001 cryptosporidiosis NA BeFree Detail
0.016 cystic fibrosis In a previous cross-sectional study from our centre the clinical effect (as desc... BeFree,GAD,LHGDN 24853301 Detail
0.080 cystitis NA RGD Detail
<0.001 Cyst NA BeFree Detail
0.002 Cytomegalovirus Infections The allelic as well as genotypic frequencies of TNF-α and IL-10 did not signific... BeFree 25208755 Detail
0.002 Deafness NA GAD Detail
0.003 Cessation of life NA LHGDN Detail
<0.001 Delirium NA BeFree Detail
0.004 Presenile dementia NA BeFree Detail
<0.001 Dementia, Vascular NA BeFree Detail
<0.001 Demyelinating Diseases NA BeFree Detail
0.007 Dengue Fever High producing tumor necrosis factor alpha gene alleles in protection against se... BeFree,GAD 25589894 Detail
0.007 Dengue Fever However, while DENV-NS3 specific T cells of those with mild/sub clinical dengue ... BeFree,GAD 25875020 Detail
<0.001 dental caries NA BeFree Detail
0.002 Dental Plaque NA GAD Detail
0.008 Mental Depression TNF-α -308G/A and IL-8 -251T/A were significantly associated with AD and IL-1β +... BeFree,GAD 25315113 Detail
0.008 Mental Depression TNF was not a moderator of the effects of either interpersonal or non-interperso... BeFree,GAD 25596176 Detail
0.008 Mental Depression Long-term potentiation and depression are reduced in colitic animals, and the sy... BeFree,GAD 26378439 Detail
0.004 depressive disorder TNF-α -308G/A and IL-8 -251T/A were significantly associated with AD and IL-1β +... BeFree 25315113 Detail
0.004 depressive disorder TNF was not a moderator of the effects of either interpersonal or non-interperso... BeFree 25596176 Detail
0.004 depressive disorder Long-term potentiation and depression are reduced in colitic animals, and the sy... BeFree 26378439 Detail
0.002 dermatitis The present study suggests that there is a lack of association of potent proinfl... BeFree 24673179 Detail
0.003 dermatitis herpetiformis NA BeFree,GAD Detail
0.015 Dermatitis, Atopic NA BeFree,GAD,LHGDN Detail
0.003 contact dermatitis Genetic endowment of proinflammatory cytokine tumor necrosis factor-α (-) 308 G ... BeFree,LHGDN 24673179 Detail
0.146 dermatomyositis Associations between TNF-α-308A/G polymorphism and susceptibility with dermatomy... BeFree,CTD_human,GAD,LHGDN 25101759 Detail
0.004 scleroderma NA BeFree,GAD Detail
0.011 Diabetes The hypermethylation of TNFα in adipose tissue may contribute to reduce the infl... BeFree 25003704 Detail
0.011 Diabetes TNF and receptor activator of NF-κB ligand (RANKL), two ligands associated with ... BeFree 26122662 Detail
0.039 diabetes mellitus The hypermethylation of TNFα in adipose tissue may contribute to reduce the infl... BeFree,GAD,LHGDN 25003704 Detail
0.039 diabetes mellitus TNF and receptor activator of NF-κB ligand (RANKL), two ligands associated with ... BeFree,GAD,LHGDN 26122662 Detail
0.200 Diabetes Mellitus, Experimental NA CTD_human,RGD Detail
0.227 Diabetes Mellitus, Insulin-Dependent In conclusion, our meta-analysis results indicate that TNF -308 A/G and -857 T/C... BeFree,CTD_human,GAD,LHGDN 24515539 Detail
0.227 Diabetes Mellitus, Insulin-Dependent Linkage disequilibrium with HLA-DRB1-DQB1 haplotypes explains the association of... BeFree,CTD_human,GAD,LHGDN 25965561 Detail
0.003 Diabetic Angiopathies NA BeFree,GAD Detail
0.096 Diabetic Nephropathy The present study aims to examine the association of tumor necrosis factor-α (TN... BeFree,GAD,LHGDN,RGD 24655058 Detail
0.096 Diabetic Nephropathy Genetic variants in angiotensin-converting enzyme (ACE), tumor necrosis factor-a... BeFree,GAD,LHGDN,RGD 25656761 Detail
0.096 Diabetic Nephropathy Association of tumor necrosis factor (TNF) promoter polymorphisms with plasma TN... BeFree,GAD,LHGDN,RGD 25704106 Detail
0.096 Diabetic Nephropathy Oxidative stress and its association with TNF-α-308 G/C and IL-1α-889 C/T gene p... BeFree,GAD,LHGDN,RGD 25732517 Detail
0.080 Diabetic Neuropathies NA RGD Detail
0.024 diabetic retinopathy The present study aims to examine the association of tumor necrosis factor-α (TN... BeFree,GAD,LHGDN 24655058 Detail
0.024 diabetic retinopathy Since TNFα and IGFBP-3 are key mediators of retinal damage and protection respec... BeFree,GAD,LHGDN 25073020 Detail
0.024 diabetic retinopathy In a case-control study, the -238G>A (rs361525), -308G>A (rs1800629), and -857C>... BeFree,GAD,LHGDN 25634985 Detail
0.003 diarrhea NA BeFree,GAD Detail
<0.001 diphtheria NA BeFree Detail
<0.001 disc disorder NA BeFree Detail
<0.001 disseminated intravascular coagulation NA BeFree Detail
0.003 Diverticulum NA LHGDN Detail
0.008 Down syndrome NA BeFree,GAD,LHGDN Detail
<0.001 Drug abuse NA BeFree Detail
0.125 drug allergy NA CTD_human,GAD Detail
<0.001 Muscular Dystrophy, Duchenne NA BeFree Detail
0.003 Duodenal Diseases NA BeFree,GAD Detail
0.034 duodenal ulcer NA BeFree,GAD,LHGDN Detail
<0.001 dysentery NA BeFree Detail
0.003 Amebic colitis NA LHGDN Detail
<0.001 Shigella Infections NA BeFree Detail
0.014 eclampsia The mechanisms may include the following pathways: [TGFB1 or TNFA]-[IL1B]-[pre-e... BeFree,GAD 25879409 Detail
<0.001 Ectromelia NA BeFree Detail
0.007 Eczema NA BeFree,GAD Detail
0.122 Edema NA CTD_human,GAD Detail
0.002 Pathological accumulation of air in tissues NA GAD Detail
0.083 encephalitis NA BeFree,GAD,RGD Detail
<0.001 Japanese encephalitis NA BeFree Detail
0.005 encephalomyelitis NA GAD,LHGDN Detail
0.002 Experimental Autoimmune Encephalomyelitis NA BeFree Detail
<0.001 endocarditis NA BeFree Detail
<0.001 Bacterial Endocarditis In this study, 14 single nucleotide variants (SNVs) in genes coding for interleu... BeFree 25299518 Detail
<0.001 Endometrial Neoplasms NA BeFree Detail
0.119 endometriosis Tumor necrosis factor gene polymorphisms and endometriosis in Asians: a systemat... BeFree,GAD,LHGDN,RGD 24791888 Detail
0.119 endometriosis Behavior of tumor necrosis factor-α and tumor necrosis factor receptor 1/tumor n... BeFree,GAD,LHGDN,RGD 24844917 Detail
0.080 endophthalmitis NA RGD Detail
<0.001 Eosinophilia NA BeFree Detail
<0.001 Toxic Epidermal Necrolysis NA BeFree Detail
<0.001 Epilepsy, Temporal Lobe NA BeFree Detail
0.002 Equine Infectious Anemia NA GAD Detail
<0.001 erythema multiforme NA BeFree Detail
0.006 erythema nodosum NA BeFree,GAD Detail
<0.001 Esophageal Achalasia NA BeFree Detail
0.003 Esophageal and Gastric Varices NA LHGDN Detail
0.017 Esophageal Neoplasms Taken together, our data indicate that RIPK3 and autocrine production of TNFα co... BeFree,GAD 24959694 Detail
0.003 esophagitis NA BeFree,GAD Detail
0.083 peptic esophagitis NA BeFree,GAD,RGD Detail
<0.001 Exanthema NA BeFree Detail
0.003 Disorder of eye NA BeFree,GAD Detail
0.128 Fanconi anemia NA BeFree,CTD_human,LHGDN Detail
0.002 farmer's lung NA GAD Detail
<0.001 fasciitis NA BeFree Detail
0.003 chronic fatigue syndrome NA BeFree,GAD Detail
0.144 Fatty Liver NA BeFree,CTD_human,GAD,LHGDN Detail
0.002 Femur Head Necrosis NA GAD Detail
0.002 Fetal Diseases NA GAD Detail
0.007 Fetal Growth Retardation NA GAD,LHGDN Detail
0.005 Fetal Membranes, Premature Rupture NA GAD Detail
0.122 Fever NA CTD_human,GAD Detail
0.003 Periodic fever NA BeFree Detail
0.002 breast fibrocystic disease NA GAD Detail
0.003 fibromyalgia NA BeFree,LHGDN Detail
0.003 fibrosarcoma NA BeFree Detail
0.140 Fibrosis NA CTD_human,GAD,LHGDN Detail
<0.001 filariasis NA BeFree Detail
<0.001 pathologic fistula NA BeFree Detail
0.002 Furunculosis NA GAD Detail
0.003 gallbladder neoplasm NA LHGDN Detail
0.021 gastritis NA BeFree,GAD,LHGDN Detail
0.013 Gastritis, Atrophic NA BeFree,GAD Detail
0.002 Gastritis, Hypertrophic NA GAD Detail
0.002 gastroenteritis NA GAD Detail
0.007 gastroesophageal reflux disease NA BeFree,GAD Detail
0.003 Gastrointestinal Diseases NA BeFree,GAD Detail
0.002 Gastrointestinal Neoplasms NA GAD Detail
0.003 Gaucher disease NA BeFree,LHGDN Detail
0.005 Gingival Diseases Tumour necrosis factor-alpha (TNF-α) plays a critical role in the pathogenesis o... BeFree 24905365 Detail
0.005 Gingival Diseases The purpose of this study was to determine the differences in the distribution o... BeFree 25647273 Detail
0.005 gingivitis NA BeFree,GAD,LHGDN Detail
0.084 glaucoma NA BeFree,LHGDN,RGD Detail
0.010 Glaucoma, Open-Angle NA BeFree,GAD Detail
0.008 glioblastoma The effect of a TNFα-producing adipose tissue-derived MSC (AT-MSC/hTNFα) was tes... BeFree 25677845 Detail
0.136 Glioma Recently, we have reported that the cardiac glycoside lanatoside C (Lan C) sensi... BeFree,CTD_human,LHGDN 24801379 Detail
0.136 Glioma Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioma cel... BeFree,CTD_human,LHGDN 25622756 Detail
0.128 glomerulonephritis NA BeFree,CTD_human,GAD Detail
0.015 IgA glomerulonephritis Furthermore, the basal intracellular protein levels of TNF in monocytes were low... BeFree,GAD,LHGDN 25770168 Detail
0.006 membranous glomerulonephritis NA BeFree,GAD Detail
0.003 Focal glomerulosclerosis NA BeFree,GAD Detail
0.003 Glossitis, Benign Migratory NA BeFree,GAD Detail
0.005 gout NA BeFree,GAD Detail
0.050 Graft-vs-Host Disease Thus, ADCC-defective Fn14-blocking antibodies are not only possible novel GVL ef... BeFree,GAD,LHGDN 26012567 Detail
0.005 Granuloma NA GAD,LHGDN Detail
0.001 chronic granulomatous disease NA BeFree Detail
0.032 Graves Disease The group with Graves' disease also registered a higher frequency of the allele ... BeFree,GAD 25127106 Detail
0.032 Graves Disease Increased level of IL-37 in patients with GD are associated with TNF-α, IL-6, IL... BeFree,GAD 25226272 Detail
0.011 Guillain-Barre syndrome NA BeFree,GAD,LHGDN Detail
0.002 Hand Dermatoses NA GAD Detail
<0.001 Hay fever NA BeFree Detail
0.007 Head and Neck Neoplasms NA GAD,LHGDN Detail
0.003 Headache NA BeFree,LHGDN Detail
0.002 Hearing Loss, Partial NA GAD Detail
0.080 Noise-induced hearing loss NA RGD Detail
<0.001 Sensorineural Hearing Loss (disorder) NA BeFree Detail
0.201 cardiac arrest NA BeFree,CTD_human,RGD Detail
0.003 Heart block NA LHGDN Detail
<0.001 congenital heart defects NA BeFree Detail
0.009 Heart Diseases To our knowledge, this is the first animal model showing both polyarthritis and ... BeFree,GAD,LHGDN 26195802 Detail
0.120 Cardiomegaly NA CTD_human Detail
0.224 Heart failure NA BeFree,CTD_human,GAD,LHGDN,RGD Detail
0.008 congestive heart failure NA BeFree Detail
<0.001 Atrial Septal Defects NA BeFree Detail
0.003 heart valve disease These results emphasize the therapeutic potential of anti-TNF drugs for the trea... BeFree,GAD 26195802 Detail
0.120 Heat Stroke NA CTD_human Detail
<0.001 Helminthiasis NA BeFree Detail
<0.001 hemiplegia NA BeFree Detail
0.131 hemochromatosis NA BeFree,CTD_human,GAD Detail
0.120 hemolytic-uremic syndrome NA CTD_human Detail
0.010 Hemophilia A NA BeFree,GAD Detail
<0.001 Hemoptysis NA BeFree Detail
0.005 Hemorrhage NA GAD Detail
<0.001 Hemorrhagic Fever, Crimean NA BeFree Detail
0.007 Severe Dengue The overall findings of the study support the correlation of high-producer TNF-α... BeFree,GAD,LHGDN 25589894 Detail
0.010 Hemorrhagic Fever with Renal Syndrome NA BeFree,GAD Detail
0.120 hepatic encephalopathy NA CTD_human Detail
<0.001 hepatic veno-occlusive disease NA BeFree Detail
0.012 hepatitis NA BeFree,LHGDN Detail
0.004 hepatitis A NA BeFree Detail
0.065 hepatitis B Assess IBD patients starting anti-TNF for the impact of preventive measures in H... BeFree,GAD,LHGDN 25052345 Detail
0.065 hepatitis B Alternative splicing-regulated protein of hepatitis B virus hacks the TNF-α-stim... BeFree,GAD,LHGDN 25630972 Detail
0.065 hepatitis B Tumor necrosis factor-alpha blockage therapy impairs hepatitis B viral clearance... BeFree,GAD,LHGDN 25661729 Detail
0.065 hepatitis B The relationship between TNF alpha gene polymorphisms (-238/-308), TNF RII VNTR ... BeFree,GAD,LHGDN 25982858 Detail
0.132 Hepatitis, Alcoholic NA BeFree,CTD_human,GAD,LHGDN Detail
0.004 Hepatitis, Chronic NA BeFree,LHGDN Detail
0.002 Hepatitis, Viral, Human NA GAD Detail
0.054 hepatitis C Combined impact of hepatitis C virus genotype 1 and interleukin-6 and tumor necr... BeFree,GAD,LHGDN 25193024 Detail
0.120 Hepatolenticular Degeneration NA BeFree,CTD_human Detail
0.081 hepatorenal syndrome NA BeFree,RGD Detail
<0.001 Hernia NA BeFree Detail
0.120 Diaphragmatic hernia NA CTD_human Detail
0.002 Herpes NOS Herpes virus entry mediator (HVEM), also known as tumour necrosis factor recepto... BeFree 25468715 Detail
0.005 Herpes Simplex Infections TNF-α was by far the most prominent cytokine in the supernatant and also within ... BeFree 25840914 Detail
<0.001 Herpesviridae Infections NA BeFree Detail
0.003 Histiocytosis, Langerhans-Cell NA BeFree,LHGDN Detail
<0.001 histoplasmosis NA BeFree Detail
0.083 HIV Infections During acute HIV infection, circulating Gal-9 was detected as early as 5 days af... BeFree,GAD,LHGDN 24786365 Detail
0.083 HIV Infections High producer haplotype (CAG) of -863C/A, -308G/A and -238G/A polymorphisms in t... BeFree,GAD,LHGDN 24837009 Detail
0.083 HIV Infections Role of TNF block genetic variants in HIV-associated sensory neuropathy in black... BeFree,GAD,LHGDN 24896147 Detail
0.083 HIV Infections In HIV-infected men, semen bacterial load correlated with seven pro-inflammatory... BeFree,GAD,LHGDN 25058515 Detail
0.083 HIV Infections As this response was inhibited by a blocking anti-TNFα antibody, drug targeting ... BeFree,GAD,LHGDN 25090652 Detail
0.083 HIV Infections The indirect mechanism by which Tat activates the HERV-Ws through induction of T... BeFree,GAD,LHGDN 25250834 Detail
0.083 HIV Infections Cardiac morbidity in an HIV-1 lipodystrophy patient cohort expressing the TNF-α-... BeFree,GAD,LHGDN 25439236 Detail
0.083 HIV Infections Genetic variation in the promoter region of pro-inflammatory cytokine TNF-α in p... BeFree,GAD,LHGDN 25544182 Detail
0.083 HIV Infections Herpes simplex virus type 2-infected dendritic cells produce TNF-α, which enhanc... BeFree,GAD,LHGDN 25840914 Detail
0.016 Hodgkin Disease Genetic polymorphism of tumor necrosis factor promoter region and susceptibility... BeFree,GAD,LHGDN 24033107 Detail
<0.001 HTLV-I Infections NA BeFree Detail
<0.001 Huntington disease NA BeFree Detail
0.201 Hyperalgesia NA BeFree,CTD_human,RGD Detail
0.120 Hyperbilirubinemia NA CTD_human Detail
0.121 hypercalcemia NA BeFree,CTD_human Detail
<0.001 Hypercholesterolemia NA BeFree Detail
<0.001 Hypercholesterolemia, Familial NA BeFree Detail
0.003 Hyperemesis Gravidarum NA LHGDN Detail
<0.001 Hypergammaglobulinemia NA BeFree Detail
0.011 hyperglycemia Modulation of hyperglycemia and TNFα-mediated inflammation by helichrysum and gr... BeFree,GAD,LHGDN 25003704 Detail
0.003 hyperinsulinism NA BeFree,LHGDN Detail
0.011 Hyperlipidemia We confirmed that the plasma sP‑selectin levels were increased in patients with ... BeFree,GAD 25384966 Detail
0.011 Hyperlipidemia Adamts7 expression was induced in response to injury and hyperlipidemia but was ... BeFree,GAD 25712206 Detail
<0.001 Hyperlipidemia, Familial Combined NA BeFree Detail
<0.001 hyperparathyroidism NA BeFree Detail
0.003 Hyperplasia NA LHGDN Detail
0.137 Hypersensitivity NA CTD_human,GAD Detail
0.005 Immediate hypersensitivity NA GAD,LHGDN Detail
0.240 Hypertensive disease NA BeFree,CTD_human,GAD,LHGDN,RGD Detail
<0.001 Hypertension, Portal NA BeFree Detail
0.121 pulmonary hypertension NA BeFree,CTD_human Detail
0.080 renal hypertension NA RGD Detail
0.120 hypoglycemia NA CTD_human Detail
0.120 Hypotension NA CTD_human Detail
0.120 Hypothermia, natural NA CTD_human Detail
0.002 hypothyroidism NA GAD Detail
<0.001 Ileal Diseases NA BeFree Detail
0.001 ileitis We observed that the frequency of CCR7-expressing TH1/TH17 effector lymphocytes ... BeFree 25637591 Detail
<0.001 Angioimmunoblastic Lymphadenopathy NA BeFree Detail
0.002 Immunologic Deficiency Syndromes The tumour suppressing effect of AT-MSC/hTNFα on A375 melanoma xenografts was mo... BeFree 25677845 Detail
0.002 Immune System Diseases Despite the small number of patients in our cohort, our results are quite encour... BeFree 24206262 Detail
0.003 Neonatal disorder NA BeFree,GAD Detail
0.003 Infarction NA LHGDN Detail
0.003 infectious mononucleosis NA BeFree,GAD Detail
0.002 Female infertility NA GAD Detail
0.005 male infertility NA BeFree,GAD Detail
0.230 Inflammation NA CTD_human,GAD,LHGDN Detail
0.183 Inflammatory Bowel Diseases In addition, the cytokines IL-1β, IL-6 and IFN-γ may be potential targets for tr... BeFree,CTD_human,GAD,LHGDN 24776844 Detail
0.183 Inflammatory Bowel Diseases TNFα overexpression has been associated with several chronic inflammatory diseas... BeFree,CTD_human,GAD,LHGDN 24802997 Detail
0.183 Inflammatory Bowel Diseases SIRT1 expression was downregulated in control LPMC by tumor necrosis factor (TNF... BeFree,CTD_human,GAD,LHGDN 24850427 Detail
0.183 Inflammatory Bowel Diseases Sera from 25 anti-tumor necrosis factor naive patients with inflammatory bowel d... BeFree,CTD_human,GAD,LHGDN 24906181 Detail
0.183 Inflammatory Bowel Diseases Impact of surveillance of hepatitis b and hepatitis c in patients with inflammat... BeFree,CTD_human,GAD,LHGDN 25052345 Detail
0.183 Inflammatory Bowel Diseases IL-17A alone weakly affects the transcriptome of intestinal epithelial cells but... BeFree,CTD_human,GAD,LHGDN 25105947 Detail
0.183 Inflammatory Bowel Diseases These data may be useful prognostically as predictors of early response to anti-... BeFree,CTD_human,GAD,LHGDN 25171510 Detail
0.183 Inflammatory Bowel Diseases MicroRNA-346 mediates tumor necrosis factor α-induced downregulation of gut epit... BeFree,CTD_human,GAD,LHGDN 25192497 Detail
0.183 Inflammatory Bowel Diseases Opposite effects of interferon regulatory factor 1 and osteopontin on the apopto... BeFree,CTD_human,GAD,LHGDN 25208103 Detail
0.183 Inflammatory Bowel Diseases Additionally, polymorphisms of TNF-α gene are known to affect the gene expressio... BeFree,CTD_human,GAD,LHGDN 25386052 Detail
0.183 Inflammatory Bowel Diseases Tumor necrosis factor superfamily (TNFSF) proteins are involved in the genesis o... BeFree,CTD_human,GAD,LHGDN 25501099 Detail
0.183 Inflammatory Bowel Diseases Although inhibition of tumor necrosis factor has been highly successful as a str... BeFree,CTD_human,GAD,LHGDN 25523553 Detail
0.183 Inflammatory Bowel Diseases Reverse transcription-PCR analysis showed that RANTES, Toll-like receptor 9, and... BeFree,CTD_human,GAD,LHGDN 25544730 Detail
0.183 Inflammatory Bowel Diseases Ablation of tumor necrosis factor is associated with decreased inflammation and ... BeFree,CTD_human,GAD,LHGDN 25775453 Detail
0.183 Inflammatory Bowel Diseases Thus, ADCC-defective Fn14-blocking antibodies are not only possible novel GVL ef... BeFree,CTD_human,GAD,LHGDN 26012567 Detail
0.183 Inflammatory Bowel Diseases We summarize recent progress in the pharmacogenetics of IBD with respect to part... BeFree,CTD_human,GAD,LHGDN 26255561 Detail
0.007 influenza In 55 subjects with paired exacerbation data, qPCR bacterial load fold change at... BeFree,LHGDN 25103335 Detail
0.231 Insulin resistance NA CTD_human,GAD,RGD Detail
<0.001 intermittent claudication Systemic inflammation, as indicated by TNF-α inflammatory gene expression in per... BeFree 25095746 Detail
<0.001 Intestinal Diseases NA BeFree Detail
0.012 irritable bowel syndrome Additionally, polymorphisms of TNF-α gene are known to affect the gene expressio... BeFree,GAD 25386052 Detail
0.005 ischemia Further, ablation of SP-D had no effect on the ischemia-induced increase in TNF ... BeFree 25038795 Detail
0.002 arthropathy Our results support clinical trial data showing that PsA skin and joint disease ... BeFree 25512250 Detail
<0.001 keratitis NA BeFree Detail
<0.001 actinic keratosis NA BeFree Detail
0.025 Kidney Diseases Tumour necrosis factor-a (TNF-α) is an important cytokine involved in initiation... BeFree,GAD,LHGDN 25589331 Detail
0.007 Kidney Failure, Acute NA BeFree,GAD Detail
0.161 Kidney Failure, Chronic Association of tumour necrosis factor-α polymorphism in patients with end stage ... BeFree,CTD_human,GAD,LHGDN 25589331 Detail
0.007 Kidney Neoplasm NA GAD,LHGDN Detail
0.018 Premature Obstetric Labor NA GAD,LHGDN Detail
0.003 Lambert-Eaton myasthenic syndrome NA BeFree,LHGDN Detail
0.002 Laryngeal neoplasm NA GAD Detail
0.006 Fibroid Tumor NA BeFree,GAD,LHGDN Detail
0.124 leishmaniasis Association of leishmaniasis with TNF alpha promoter and SLC11A1 gene polymorphi... BeFree,CTD_human,LHGDN 25603101 Detail
0.127 Leishmaniasis, Cutaneous None of the TNF-α alleles and genotypes was associated either to CL or to VL. BeFree,CTD_human,GAD 25603101 Detail
<0.001 Infection by Leishmania braziliensis NA BeFree Detail
0.122 Leishmaniasis, Visceral Visceral leishmaniasis (VL) is associated with increased circulating levels of m... BeFree,CTD_human 25275531 Detail
0.122 Leishmaniasis, Visceral None of the TNF-α alleles and genotypes was associated either to CL or to VL. BeFree,CTD_human 25603101 Detail
0.020 leprosy In both cases lower TNF levels correlates with subjects carrying the risk C-alle... BeFree,GAD,LHGDN 25187983 Detail
0.020 leprosy Association of TNF -1031 C/C as a potential protection marker for leprosy develo... BeFree,GAD,LHGDN 25636570 Detail
0.020 leprosy Association of TNF-α-(308(GG)), IL-10(-819(TT)), IL-10(-1082(GG)) and IL-1R1(+19... BeFree,GAD,LHGDN 25697140 Detail
0.001 Leprosy, Lepromatous NA BeFree Detail
<0.001 tuberculoid leprosy NA BeFree Detail
0.005 leptospirosis NA GAD Detail
0.016 leukemia Targeting tmTNF-α by C1 resulted in leukemia cell killing via antibody-dependent... BeFree,LHGDN 26224647 Detail
0.016 leukemia The aim of this study is to explore the spatial association of critical genomic ... BeFree,LHGDN 26260845 Detail
0.021 chronic lymphocytic leukemia NA BeFree,GAD,LHGDN Detail
<0.001 Acute Erythroblastic Leukemia NA BeFree Detail
0.002 hairy cell leukemia NA BeFree Detail
0.004 lymphoid leukemia NA BeFree,LHGDN Detail
0.002 Acute lymphocytic leukemia Donors with HLA-B*58:01/TNFα − 308A haplotype are unfavorable to haploidentical ... BeFree 25545232 Detail
0.003 Leukemia, Lymphocytic, Acute, L1 NA BeFree,GAD Detail
<0.001 acute monocytic leukemia NA BeFree Detail
0.018 Leukemia, Myelocytic, Acute No significant difference in gene expression was detected between AML BM-MSCs co... BeFree,GAD,LHGDN 25860293 Detail
0.002 myeloid leukemia NA BeFree Detail
0.003 Myeloid Leukemia, Chronic NA BeFree Detail
<0.001 Leukemia, Myelomonocytic, Chronic NA BeFree Detail
0.002 acute promyelocytic leukemia NA BeFree Detail
<0.001 Leukemia, T-Cell NA BeFree Detail
<0.001 Adult T-Cell Lymphoma/Leukemia NA BeFree Detail
<0.001 Leukoencephalopathy, Progressive Multifocal NA BeFree Detail
0.081 Leukomalacia, Periventricular NA BeFree,RGD Detail
<0.001 leukopenia NA BeFree Detail
0.006 lichen planus Paradoxically, numerous studies have reported new-onset psoriasis and lichen pla... BeFree,GAD,LHGDN 24802997 Detail
0.012 lipodystrophy The contribution of genetic determinants such as the TNF-α 238G/A SNP to lipodys... BeFree,GAD,LHGDN 25439236 Detail
0.121 listeriosis NA BeFree,CTD_human Detail
0.024 liver cirrhosis Genetic heterogeneity in the TNFα and IL1β gene promoters influences the risk of... BeFree,GAD 24751829 Detail
0.024 liver cirrhosis Our study suggests that CB2R agonists have the potential to treat BT and various... BeFree,GAD 24953022 Detail
0.024 liver cirrhosis Liver cirrhosis was associated with a -238 TNF-α polymorphism in these patients. BeFree,GAD 25013899 Detail
0.024 liver cirrhosis To assess the contribution of tumor necrosis factor (TNF)β +252 polymorphisms to... BeFree,GAD 25556449 Detail
0.129 Liver Cirrhosis, Alcoholic NA BeFree,CTD_human,GAD Detail
0.007 Biliary cirrhosis NA GAD Detail
0.120 Liver Cirrhosis, Experimental NA CTD_human Detail
0.136 Liver diseases NA BeFree,CTD_human,GAD,LHGDN Detail
0.027 Alcoholic Liver Diseases Clinical studies evaluating combination therapy of carvedilol with a TNF-α inhib... BeFree,GAD,LHGDN 25356030 Detail
0.158 Liver neoplasms NA BeFree,CTD_human,GAD Detail
0.205 Lung diseases NA BeFree,CTD_human,GAD,RGD Detail
0.082 Lung Diseases, Fungal NA GAD,RGD Detail
0.144 Lung Neoplasms Based on the TNF-α-mediated genes that were dysregulated in lung tumors, we deve... BeFree,CTD_human,GAD,LHGDN 25548907 Detail
0.008 Lupus Vulgaris Since chronic local activation of proinflammatory cytokines including TNF-α in r... BeFree,GAD 24627031 Detail
<0.001 Lupus Erythematosus, Cutaneous NA BeFree Detail
0.011 Lupus Erythematosus, Discoid Since chronic local activation of proinflammatory cytokines including TNF-α in r... BeFree,GAD 24627031 Detail
0.001 Lupus Erythematosus, Subacute Cutaneous NA BeFree Detail
0.121 Lupus Erythematosus, Systemic Since chronic local activation of proinflammatory cytokines including TNF-α in r... BeFree,GAD,LHGDN 24627031 Detail
0.121 Lupus Erythematosus, Systemic Association of TLR4 (D299G, T399I), TLR9 -1486T>C, TIRAP S180L and TNF-α promote... BeFree,GAD,LHGDN 25182168 Detail
0.121 Lupus Erythematosus, Systemic Serum VEGF level in the active SLE group was significantly higher than that in t... BeFree,GAD,LHGDN 25359881 Detail
0.121 Lupus Erythematosus, Systemic Association of TNF-α with impaired migration capacity of mesenchymal stem cells ... BeFree,GAD,LHGDN 25762184 Detail
0.003 lupus nephritis Tumor necrosis factor-α synergistically enhances polyinosinic-polycytidylic acid... BeFree 24627031 Detail
<0.001 Lyme disease NA BeFree Detail
0.002 Lymphatic Metastasis NA GAD Detail
0.002 Lymphocytosis NA GAD Detail
0.006 Lymphohistiocytosis, Hemophagocytic NA BeFree,GAD,LHGDN Detail
0.015 lymphoma NA BeFree,GAD Detail
0.007 Lymphoma, Follicular NA BeFree,GAD Detail
0.050 Lymphoma, Non-Hodgkin The association between the polymorphisms of TNF-α and non-Hodgkin lymphoma: a m... BeFree,GAD,LHGDN 25204673 Detail
0.010 Lymphoproliferative Disorders NA BeFree,GAD Detail
<0.001 Waldenstrom Macroglobulinemia NA BeFree Detail
<0.001 Single major depressive episode PDLIM5, S100A10 and TNF mRNA showed also an interesting pattern of expression wi... BeFree 24620999 Detail
0.011 Malaria, Cerebral NA BeFree,GAD,LHGDN Detail
0.027 Malaria, Falciparum IFN-gamma and TNF associated with severe falciparum malaria infection in Saudi p... BeFree,GAD 25124540 Detail
0.009 Malaria, Vivax DDX39B (BAT1), TNF and IL6 gene polymorphisms and association with clinical outc... BeFree,GAD,LHGDN 25038626 Detail
0.034 Malignant neoplasm of stomach Tumor necrosis factor-related apoptosis inducing ligand gene polymorphisms are c... BeFree,GAD 24277417 Detail
0.034 Malignant neoplasm of stomach Association between TNF-α-308 G/A gene polymorphism and gastric cancer risk: a s... BeFree,GAD 25125137 Detail
0.034 Malignant neoplasm of stomach Clinical study on gastric cancer susceptibility genes IL-10-1082 and TNF-α. BeFree,GAD 25526211 Detail
0.034 Malignant neoplasm of stomach These results suggest that claudin 1 is an important messenger that regulates TN... BeFree,GAD 25548484 Detail
0.005 Animal Mammary Neoplasms NA GAD Detail
<0.001 paroxysmal nocturnal hemoglobinuria NA BeFree Detail
0.006 measles NA BeFree,GAD Detail
<0.001 medulloblastoma NA BeFree Detail
0.145 melanoma Genetically engineered mesenchymal stromal cells producing TNFα have tumour supp... BeFree,CTD_human,GAD,LHGDN 25677845 Detail
0.145 melanoma We identified DNA copy-number gain and constitutive ubiquitination by a TNFα aut... BeFree,CTD_human,GAD,LHGDN 25724678 Detail
0.002 Memory Disorders NA GAD Detail
<0.001 meningioma NA BeFree Detail
0.001 meningitis NA BeFree Detail
0.080 Meningitis, Pneumococcal NA RGD Detail
0.009 Meningococcal Infections NA BeFree,GAD Detail
<0.001 Meningococcemia NA BeFree Detail
<0.001 meningoencephalitis NA BeFree Detail
<0.001 Mesothelioma We reasoned that the anti-inflammatory actions of mesenchymal stromal cells (MSC... BeFree 25525034 Detail
0.001 Metabolic Diseases Furthermore, CCF polyphones significantly ameliorated both HFD-induced metabolic... BeFree 25367327 Detail
0.007 Metaplasia NA GAD Detail
<0.001 mitral valve insufficiency NA BeFree Detail
0.002 mitral valve stenosis NA BeFree Detail
0.003 mixed connective tissue disease NA BeFree,GAD Detail
<0.001 Monoclonal Gammopathy of Undetermined Significance NA BeFree Detail
0.014 Mouth Neoplasms NA GAD Detail
0.025 Mucocutaneous Lymph Node Syndrome Tumor necrosis factor receptor-associated periodic syndrome (TRAPS), formerly kn... BeFree,GAD,LHGDN 24935411 Detail
0.025 Mucocutaneous Lymph Node Syndrome Infliximab (IFX), a known monoclonal antibody against tumor necrosis factor-α (T... BeFree,GAD,LHGDN 24964229 Detail
0.032 multiple myeloma NA BeFree,GAD,LHGDN Detail
0.130 Multiple Organ Failure NA CTD_human,GAD,LHGDN Detail
<0.001 craniosynostosis To replicate and extend recent findings in a Turkish population of associations ... BeFree 20157068 Detail
0.085 multiple sclerosis Stimulated PBMC-produced IFN-γ and TNF-α are associated with altered relapse ris... BeFree,GAD,LHGDN 24790215 Detail
0.085 multiple sclerosis Genetic variation in PBMC-produced IFN-γ and TNF-α associations with relapse in ... BeFree,GAD,LHGDN 25575858 Detail
0.085 multiple sclerosis We also demonstrate upregulation of CB1 and CB2 and increased IL-1β, IL-6 and TN... BeFree,GAD,LHGDN 25704169 Detail
0.085 multiple sclerosis Finally, we show that necroptosis mediates oligodendrocyte degeneration induced ... BeFree,GAD,LHGDN 25801023 Detail
0.002 mumps NA GAD Detail
0.003 muscular atrophy NA BeFree,GAD Detail
0.003 myopathy NA BeFree,GAD Detail
0.003 Musculoskeletal Diseases NA BeFree,GAD Detail
0.010 myasthenia gravis The influence of the pro-inflammatory environment is discussed, particularly the... BeFree,GAD 24389034 Detail
0.010 myasthenia gravis B cells produce less IL-10, IL-6 and TNF-α in myasthenia gravis. BeFree,GAD 25518708 Detail
0.003 Mycobacterium avium-intracellulare Infection NA BeFree,GAD Detail
0.003 Mycobacterium Infections We highlight granuloma heterogeneity that emerges in the context of infection, t... BeFree 25703566 Detail
0.003 Mycobacterium Infections Control of Mycobacterial Infections in Mice Expressing Human Tumor Necrosis Fact... BeFree 26123801 Detail
0.001 Mycoplasma Infections NA BeFree Detail
0.001 Mycoses NA BeFree Detail
<0.001 mycosis fungoides NA BeFree Detail
0.003 Myelodysplasia NA BeFree,GAD Detail
<0.001 Myelomonocytic leukemia NA BeFree Detail
<0.001 Myeloproliferative disease Plasma concentrations of interleukin 6, interleukin 15, and tumor necrosis facto... BeFree 25912019 Detail
0.248 myocardial infarction NA BeFree,CTD_human,GAD,LHGDN,RGD Detail
0.080 Myocardial Reperfusion Injury NA RGD Detail
0.124 myocarditis NA BeFree,CTD_human,GAD Detail
<0.001 Myosarcoma NA BeFree Detail
0.004 myositis NA BeFree,LHGDN Detail
0.004 Myotonic dystrophy NA BeFree,LHGDN Detail
0.010 narcolepsy Elevations of interleukin (IL)-6, IL-8, granulocyte- colony stimulating factor (... BeFree,GAD,LHGDN 24994458 Detail
0.016 Nasal Polyps NA BeFree,GAD Detail
0.005 Nasopharyngeal Neoplasms NA GAD Detail
0.120 Nausea NA CTD_human Detail
0.120 Necrosis NA CTD_human Detail
0.122 Neoplasm Invasiveness NA CTD_human,GAD Detail
0.139 Neoplasm Metastasis Tumor necrosis factor-α-inducible protein-1 (TNFAIP1) plays a role in DNA synthe... BeFree,CTD_human,GAD,LHGDN 24969828 Detail
0.139 Neoplasm Metastasis The interaction of tumor necrosis factor-α (TNF-α) with its receptors: TNFRSF1A ... BeFree,CTD_human,GAD,LHGDN 25010932 Detail
0.139 Neoplasm Metastasis A positive correlation was also obtained between TNF-α and CD44 expression, and ... BeFree,CTD_human,GAD,LHGDN 25123505 Detail
0.139 Neoplasm Metastasis Taken together, these findings demonstrate that TIPE2 was able to suppress TNF-α... BeFree,CTD_human,GAD,LHGDN 25339267 Detail
0.139 Neoplasm Metastasis Based on the recent findings that metastatic tumour cells adopt unique mechanism... BeFree,CTD_human,GAD,LHGDN 25910782 Detail
0.002 Neoplasm Recurrence, Local NA GAD Detail
0.120 Neoplasms, Experimental NA CTD_human Detail
0.002 Pathologic Neovascularization NA GAD Detail
0.006 nephritis NA BeFree,LHGDN Detail
0.002 nephrosis NA GAD Detail
0.006 nephrotic syndrome NA BeFree,GAD Detail
0.120 Nerve Degeneration NA CTD_human Detail
0.122 nervous system disorder NA BeFree,CTD_human Detail
0.121 Neuralgia Tumor necrosis factor-alpha is a potential diagnostic biomarker for chronic neur... BeFree,CTD_human 25847150 Detail
0.002 neuritis NA GAD Detail
0.080 Neuritis, Autoimmune, Experimental NA RGD Detail
0.007 neuroblastoma In the present study, the inflammatory cytokine, tumor necrosis factor‑α (TNF‑α)... BeFree 25503960 Detail
0.007 neuroblastoma TNFα sensitizes neuroblastoma cells to FasL-, cisplatin- and etoposide-induced c... BeFree 25890358 Detail
0.003 neutropenia NA BeFree,GAD Detail
0.003 Obesity, Morbid NA BeFree,GAD Detail
0.003 obsessive-compulsive disorder No association was found between OCD or obsessive-compulsive symptoms and the st... BeFree,GAD 25256363 Detail
0.007 Dermatitis, Occupational NA GAD Detail
0.005 Occupational Diseases NA GAD Detail
0.002 ocular hypertension NA GAD Detail
<0.001 oligodendroglioma NA BeFree Detail
0.003 oligospermia NA BeFree,GAD Detail
0.002 Ophthalmia, Sympathetic NA GAD Detail
<0.001 Opportunistic Infections NA BeFree Detail
<0.001 optic neuritis NA BeFree Detail
0.003 Oral Manifestations NA BeFree,LHGDN Detail
0.123 oral submucous fibrosis NA BeFree,CTD_human,GAD Detail
<0.001 orbit (eye disorders) NA BeFree Detail
<0.001 Osteitis NA BeFree Detail
0.032 Degenerative polyarthritis Our results suggest that the TNFα gene variants play a role in the etiology of h... BeFree,GAD,LHGDN 25252624 Detail
0.032 Degenerative polyarthritis Our results suggested that the TNF-α -G308A polymorphism were associated with an... BeFree,GAD,LHGDN 25398219 Detail
0.032 Degenerative polyarthritis Our study aimed to evaluate the in vitro effect of canakinumab on human osteoart... BeFree,GAD,LHGDN 25461395 Detail
0.032 Degenerative polyarthritis In addition, we investigated the correlation between serum TSLP concentrations a... BeFree,GAD,LHGDN 25817699 Detail
0.032 Degenerative polyarthritis Our results thus indicated that suppression of TNFα activity is an effective str... BeFree,GAD,LHGDN 25824140 Detail
<0.001 osteochondritis dissecans NA BeFree Detail
<0.001 osteopetrosis NA BeFree Detail
0.018 osteoporosis NA BeFree,GAD,LHGDN Detail
0.127 Osteoporosis, Postmenopausal NA BeFree,CTD_human,GAD Detail
<0.001 Osteoporosis, Senile NA BeFree Detail
0.003 osteosarcoma Tumor necrosis factor-related apoptosis-inducing ligand induces cytotoxicity spe... BeFree 25335093 Detail
0.003 osteosarcoma Anti-tumor necrosis factor therapy inhibits lung metastasis in an osteosarcoma c... BeFree 25402182 Detail
<0.001 Ear Inflammation NA BeFree Detail
0.094 otitis media NA BeFree,GAD,LHGDN,RGD Detail
0.004 Otitis Media with Effusion NA BeFree,LHGDN Detail
<0.001 otosclerosis NA BeFree Detail
0.012 ovarian carcinoma In vitro and in vivo studies have highlighted different molecular mechanisms tha... BeFree 25030086 Detail
0.012 ovarian carcinoma The effect of a TNFα-producing adipose tissue-derived MSC (AT-MSC/hTNFα) was tes... BeFree 25677845 Detail
0.002 Ovarian Diseases NA BeFree Detail
0.003 Pain, Postoperative NA BeFree,GAD Detail
0.003 Pustulosis of Palms and Soles NA BeFree,GAD Detail
0.133 Pancreatic Neoplasm NA BeFree,CTD_human,GAD,LHGDN Detail
0.040 pancreatitis Administration of MSCs alone significantly reduced pancreatic injury and inflamm... BeFree,GAD,LHGDN 25120736 Detail
0.001 pancytopenia The CART-33 infusion alone induced rigorous chills and fevers; drastic fluctuati... BeFree 25174587 Detail
<0.001 panuveitis NA BeFree Detail
0.003 paracoccidioidomycosis NA BeFree,GAD Detail
<0.001 Paratuberculosis Contrary to this, TNF-α levels were unchanged upon MAP stimulation regardless of... BeFree 25335775 Detail
0.150 Parkinson disease NA BeFree,CTD_human,GAD,LHGDN Detail
0.002 Pelvic Pain NA GAD Detail
<0.001 bullous pemphigoid NA BeFree Detail
0.016 pemphigus NA BeFree,GAD,LHGDN Detail
0.003 pemphigus vulgaris NA BeFree,GAD Detail
0.017 Peptic Ulcer TNFA-308G>A (rs1800629) and TNFA-1031T>C (rs1799964), which are responsible for ... BeFree,GAD,LHGDN 25368751 Detail
<0.001 Chronic periaortitis NA BeFree Detail
<0.001 periapical granuloma NA BeFree Detail
<0.001 periapical periodontitis NA BeFree Detail
<0.001 pericarditis NA BeFree Detail
0.010 familial Mediterranean fever NA BeFree,GAD Detail
0.019 Periodontal Diseases Tumour necrosis factor-alpha (TNF-α) plays a critical role in the pathogenesis o... BeFree,GAD,LHGDN 24905365 Detail
0.019 Periodontal Diseases The purpose of this study was to determine the differences in the distribution o... BeFree,GAD,LHGDN 25647273 Detail
0.003 Periodontal Pocket NA BeFree,GAD Detail
0.047 periodontitis TNF-α gene promoter polymorphisms contribute to periodontitis susceptibility: ev... BeFree,GAD,LHGDN 24905365 Detail
0.009 Periodontitis, Juvenile The TNF-α -308G/A AA genotype was associated with increased CP risk in Asians, n... BeFree,GAD 24905365 Detail
0.009 Periodontitis, Juvenile The results of this study revealed an association between TNF-α (-308) allele 2 ... BeFree,GAD 25647273 Detail
0.120 Peripheral neuropathy NA BeFree,CTD_human Detail
0.084 peritonitis NA BeFree,LHGDN,RGD Detail
0.002 Pharyngeal Neoplasms NA GAD Detail
<0.001 pharyngitis NA BeFree Detail
<0.001 pheochromocytoma NA BeFree Detail
0.002 Picornaviridae Infections NA GAD Detail
<0.001 Pigeon Breeder's Lung NA BeFree Detail
<0.001 Pituitary Diseases NA BeFree Detail
0.120 Placenta Disorders NA CTD_human Detail
<0.001 plasmacytoma NA BeFree Detail
<0.001 Pleural Diseases NA BeFree Detail
0.123 Pleural effusion disorder NA BeFree,CTD_human,GAD Detail
0.200 pleurisy NA CTD_human,RGD Detail
<0.001 Pneumococcal Infections NA BeFree Detail
0.010 pneumoconiosis NA BeFree,GAD Detail
0.134 pneumonia Taken together, our data demonstrate that HIF-1α acts downstream of TNF-α to inh... BeFree,CTD_human,GAD,LHGDN 25051011 Detail
0.080 aspiration pneumonia NA RGD Detail
0.013 polycystic ovary syndrome Tumor necrosis factor-alpha and polycystic ovarian syndrome: a clinical, biochem... BeFree,GAD,LHGDN 25083576 Detail
0.013 polycystic ovary syndrome Family association study between tumour necrosis factor a gene polymorphisms and... BeFree,GAD,LHGDN 25246119 Detail
0.013 polycystic ovary syndrome Associations between TNF-α and interleukin gene polymorphisms with polycystic ov... BeFree,GAD,LHGDN 25690158 Detail
<0.001 polymyalgia rheumatica NA BeFree Detail
<0.001 Adenomatous Polyposis Coli NA BeFree Detail
<0.001 polyps NA BeFree Detail
<0.001 Post-kala-azar dermal leishmaniasis NA BeFree Detail
<0.001 Postherpetic neuralgia NA BeFree Detail
0.019 Postoperative Complications NA GAD Detail
0.041 pre-eclampsia NA GAD,LHGDN Detail
0.010 Precancerous Conditions NA BeFree,GAD Detail
0.006 Pregnancy Complications NA BeFree,GAD,LHGDN Detail
0.120 Pregnancy Complications, Cardiovascular NA CTD_human Detail
0.005 Pregnancy Complications, Hematologic NA GAD Detail
0.005 Pregnancy Complications, Infectious NA GAD Detail
0.011 Preleukemia NA BeFree,GAD Detail
0.002 Prenatal Exposure Delayed Effects NA GAD Detail
<0.001 Cardiomyopathies, Primary NA BeFree Detail
0.004 Prostatic Neoplasms NA BeFree,GAD Detail
0.002 prostatitis NA GAD Detail
0.002 proteinuria NA GAD Detail
0.005 Pseudomonas Infections NA GAD Detail
<0.001 Pseudorabies NA BeFree Detail
0.187 psoriasis Prevalence of human Papillomavirus DNA in eyebrow hairs plucked from patients wi... BeFree,CTD_human,GAD,LHGDN 24206262 Detail
0.187 psoriasis Psoriasis (Ps) is an autoimmune disease characterized by keratinocyte hyperproli... BeFree,CTD_human,GAD,LHGDN 24587411 Detail
0.187 psoriasis TNFα overexpression has been associated with several chronic inflammatory diseas... BeFree,CTD_human,GAD,LHGDN 24802997 Detail
0.187 psoriasis Biological drugs such as the tumour necrosis factor inhibitors have revolutioniz... BeFree,CTD_human,GAD,LHGDN 24841895 Detail
0.187 psoriasis Additionally, the effects of the anti-TNFα drug Etanercept on metabolic profiles... BeFree,CTD_human,GAD,LHGDN 25361234 Detail
0.187 psoriasis TNF-α plays a crucial role in psoriasis; therefore, TNF inhibition has become a ... BeFree,CTD_human,GAD,LHGDN 25384035 Detail
0.187 psoriasis Hyper-production of TNF-α is documented in psoriasis. BeFree,CTD_human,GAD,LHGDN 25679113 Detail
0.187 psoriasis Methotrexate is a first-line systemic agent for treating of psoriasis, although ... BeFree,CTD_human,GAD,LHGDN 25946554 Detail
<0.001 Tension Headache NA BeFree Detail
0.003 pterygium NA BeFree,GAD Detail
0.002 Delayed puberty NA GAD Detail
0.002 Precocious Puberty NA GAD Detail
0.005 Puerperal Disorders NA GAD Detail
0.120 pulmonary edema NA CTD_human Detail
<0.001 pulmonary embolism The results of the present study suggest that the DEGs identified, including che... BeFree 25434468 Detail
0.003 pulmonary emphysema NA BeFree,GAD Detail
0.132 pulmonary fibrosis Tumor necrosis factor superfamily 14 (LIGHT) controls thymic stromal lymphopoiet... BeFree,CTD_human,GAD,LHGDN 25680454 Detail
0.003 Henoch-Schoenlein purpura NA BeFree,GAD Detail
0.005 Q fever NA BeFree,GAD Detail
<0.001 quadriplegia NA BeFree Detail
<0.001 Radicular Cyst NA BeFree Detail
<0.001 Raynaud disease NA BeFree Detail
0.002 Rectal Fistula NA GAD Detail
<0.001 Rectal Neoplasms NA BeFree Detail
0.002 reflex sympathetic dystrophy NA GAD Detail
<0.001 relapsing fever NA BeFree Detail
0.006 kidney failure NA BeFree,GAD Detail
0.122 Reperfusion Injury NA CTD_human,GAD Detail
<0.001 Respiration Disorders NA BeFree Detail
0.003 Respiratory Distress Syndrome, Newborn NA BeFree,GAD Detail
0.004 Respiratory Distress Syndrome, Adult NA BeFree,GAD Detail
0.122 Respiratory Hypersensitivity NA CTD_human,GAD Detail
0.004 Respiratory Syncytial Virus Infections NA BeFree,GAD Detail
0.128 Respiratory Tract Diseases NA BeFree,CTD_human,GAD Detail
0.005 Respiratory Tract Infections NA GAD Detail
<0.001 Reticuloendotheliosis, X-linked NA BeFree Detail
0.083 retinal detachment NA BeFree,GAD,RGD Detail
0.121 Retinal Diseases NA BeFree,CTD_human Detail
0.002 retinal vein occlusion NA GAD Detail
<0.001 retinoblastoma NA BeFree Detail
0.003 retinopathy of prematurity Investigation of TNF-alpha gene (G308A) and GSTP1 gene (Ilel05Val) polymorphisms... BeFree,GAD 25790547 Detail
0.002 Retroperitoneal fibrosis NA GAD Detail
<0.001 Retroviridae Infections NA BeFree Detail
0.002 Rhabdomyolysis NA GAD Detail
0.001 rhabdomyosarcoma Our results identify IGF2BP1 as a critical translational regulator of cIAP1-medi... BeFree 24704827 Detail
0.005 Rheumatism NA BeFree,GAD Detail
0.006 rheumatic fever NA BeFree,GAD,LHGDN Detail
0.015 rheumatic heart disease Tumor necrosis factor-alpha 308G>A polymorphism and risk of rheumatic heart dise... BeFree,GAD,LHGDN 24751687 Detail
<0.001 Rheumatoid Nodule NA BeFree Detail
0.085 rhinitis NA BeFree,GAD,RGD Detail
0.002 Rhinitis, Allergic, Perennial NA GAD Detail
<0.001 rosacea NA BeFree Detail
0.005 rubella NA BeFree,GAD Detail
0.001 Salmonella infections NA BeFree Detail
<0.001 Sandhoff disease NA BeFree Detail
0.038 sarcoidosis NA BeFree,GAD,LHGDN Detail
0.015 Sarcoidosis, Pulmonary NA BeFree,GAD Detail
<0.001 Kaposi sarcoma NA BeFree Detail
0.003 Schistosomiasis mansoni NA BeFree,LHGDN Detail
0.179 schizophrenia We report significant increases in PPARγ, SREBP1, IL-6 and TNFα, and decreases i... BeFree,CTD_human,GAD,LHGDN 25433960 Detail
<0.001 paranoid schizophrenia NA BeFree Detail
0.121 localized scleroderma NA BeFree,CTD_human Detail
0.019 systemic scleroderma NA BeFree,GAD,LHGDN Detail
<0.001 seborrheic dermatitis NA BeFree Detail
0.082 Seizures NA BeFree,RGD Detail
<0.001 seminoma NA BeFree Detail
0.021 Septicemia Toll-like receptors (TLR) recognize pathogens and trigger the production of vigo... BeFree 24758719 Detail
0.021 Septicemia TNF-α, IL-6, and IL-8 cytokines and their association with TNF-α-308 G/A polymor... BeFree 24944154 Detail
0.021 Septicemia The protection of female hearts against the dysfunction associated with sepsis i... BeFree 24945834 Detail
0.021 Septicemia In summary, this work provides the first in vivo evidence that administering BMM... BeFree 25337817 Detail
0.021 Septicemia Modulation of TNF-α mRNA stability by human antigen R and miR181s in sepsis-indu... BeFree 25535255 Detail
0.021 Septicemia Shedding of the tumor necrosis factor (TNF) receptor from the surface of hepatoc... BeFree 25628461 Detail
0.003 Sezary syndrome NA BeFree,LHGDN Detail
0.005 Shock NA GAD,LHGDN Detail
0.120 Shock, Hemorrhagic NA CTD_human Detail
0.210 Septic Shock NA CTD_human,GAD,LHGDN,RGD Detail
<0.001 Shy-Drager Syndrome NA BeFree Detail
<0.001 sialadenitis NA BeFree Detail
<0.001 siderosis NA BeFree Detail
0.012 silicosis NA BeFree,GAD,LHGDN Detail
0.007 sinusitis NA GAD Detail
0.125 Dermatologic disorders NA BeFree,CTD_human,GAD Detail
<0.001 Skin lesion Neutralization of tumor necrosis factor-α and IL-6 (both downstream of IL-17A) r... BeFree 25341795 Detail
<0.001 Skin lesion Treatment of K5.Stat3C mice with TNF-α or EGFR inhibitors attenuated the skin le... BeFree 25384035 Detail
<0.001 Skin Manifestations NA BeFree Detail
0.005 Skin Neoplasms NA BeFree,GAD Detail
0.002 Skin Ulcer NA GAD Detail
0.003 Sleep Apnea Syndromes NA BeFree,GAD Detail
0.002 Sleep Deprivation NA GAD Detail
<0.001 smallpox NA BeFree Detail
0.120 Soft Tissue Neoplasms NA CTD_human Detail
0.120 Compression of spinal cord NA CTD_human Detail
0.003 Spinal Cord Diseases NA BeFree,LHGDN Detail
<0.001 Spinal Diseases NA BeFree Detail
<0.001 spondylitis NA BeFree Detail
0.041 ankylosing spondylitis Tumor necrosis factor (TNF)-alpha promoter polymorphisms in ankylosing spondylit... BeFree,GAD,LHGDN 24643503 Detail
0.041 ankylosing spondylitis Effects of tumor necrosis factor inhibitor on serum level of HLA-B27 and PDCD-1 ... BeFree,GAD,LHGDN 25005770 Detail
0.041 ankylosing spondylitis Tumor necrosis factor-α promoter -308/238 polymorphism association with less sev... BeFree,GAD,LHGDN 25028373 Detail
0.041 ankylosing spondylitis Runt-related transcription factor 3 (RUNX3), tumor necrosis factor family member... BeFree,GAD,LHGDN 25494292 Detail
0.041 ankylosing spondylitis Effects of tumor necrosis factor-α inhibitors in mothers and daughters concordan... BeFree,GAD,LHGDN 25962691 Detail
0.002 Staphylococcal Infections NA GAD Detail
0.200 status epilepticus NA BeFree,CTD_human,RGD Detail
0.012 Stomach Diseases NA BeFree,GAD Detail
0.203 Stomach Neoplasms NA BeFree,CTD_human,GAD,LHGDN Detail
0.133 gastric ulcer NA BeFree,CTD_human,GAD Detail
<0.001 stomatitis NA BeFree Detail
0.007 aphthous stomatitis NA GAD,LHGDN Detail
0.005 Streptococcal Infections NA BeFree,GAD Detail
0.003 post-traumatic stress disorder While the elderly group exhibited robust changes in immune activity such as incr... BeFree,LHGDN 24977331 Detail
<0.001 Stress, Psychological This paper aims to investigate the association between psychological stress and ... BeFree 25081719 Detail
0.251 Cerebrovascular accident An association between stroke and TNF-α -308A allele has been suggested. BeFree,CTD_human,GAD,LHGDN,RGD 25175566 Detail
0.084 Subarachnoid Hemorrhage NA BeFree,GAD,RGD Detail
0.009 sudden infant death syndrome NA BeFree,GAD,LHGDN Detail
<0.001 synovial sarcoma NA BeFree Detail
0.001 synovitis NA BeFree Detail
<0.001 pigmented villonodular synovitis NA BeFree Detail
0.120 Tachycardia NA CTD_human Detail
<0.001 Takayasu Arteritis NA BeFree Detail
0.001 Giant Cell Arteritis NA BeFree Detail
<0.001 tenosynovitis NA BeFree Detail
0.002 Thoracic Neoplasms NA GAD Detail
0.001 Thromboembolism NA BeFree Detail
0.125 thrombosis NA CTD_human,GAD,LHGDN Detail
0.003 thymoma NA BeFree,GAD Detail
0.003 Thyroid Diseases NA BeFree,GAD Detail
0.120 Thyroid Neoplasm NA CTD_human Detail
<0.001 thyroiditis NA BeFree Detail
<0.001 Tinea Versicolor NA BeFree Detail
0.002 Tobacco use disorder NA GAD Detail
<0.001 Gilles de la Tourette syndrome Association of the tumor necrosis factor -308 A/G promoter polymorphism with Tou... BeFree 25256363 Detail
0.002 Ocular Toxoplasmosis NA GAD Detail
0.008 trachoma NA BeFree,GAD Detail
0.002 Chromosomal translocation NA GAD Detail
<0.001 Trophoblastic Neoplasms NA BeFree Detail
0.003 African Trypanosomiasis NA BeFree,GAD Detail
0.007 Chagas disease Moreover, during T. cruzi infection, this thymocyte subset expresses high levels... BeFree,GAD 25330249 Detail
<0.001 Tuberculosis, Meningeal NA BeFree Detail
<0.001 pleural tuberculosis NA BeFree Detail
0.029 Tuberculosis, Pulmonary Peripheral blood mononuclear cells from 42 healthy controls (HCs) and 42 pulmona... BeFree,GAD,LHGDN 25194676 Detail
0.029 Tuberculosis, Pulmonary The combination of IFN-γ, TNF-α, and IL-2R, and the combination of TNF-α, IL-2R,... BeFree,GAD,LHGDN 25528189 Detail
0.003 tuberous sclerosis NA BeFree,LHGDN Detail
0.005 Tumor Virus Infections NA GAD Detail
<0.001 Turner syndrome NA BeFree Detail
0.009 typhoid fever NA BeFree,GAD,LHGDN Detail
0.007 Ulcer NA GAD Detail
0.002 Unipolar Depression NA BeFree Detail
0.005 Erythema NA BeFree,GAD Detail
<0.001 Upper Respiratory Infections NA BeFree Detail
<0.001 uremia NA BeFree Detail
0.080 ureteral obstruction NA RGD Detail
0.005 urinary tract infection NA BeFree,GAD Detail
0.123 urticaria NA BeFree,CTD_human,GAD Detail
<0.001 Uterine Fibroids NA BeFree Detail
0.002 Uterine Neoplasms NA GAD Detail
0.092 uveitis TNF-α -308 GA/AA genotype was associated with a reduced risk of uveitis and bett... BeFree,GAD,RGD 25028373 Detail
0.092 uveitis New cytokine inhibitors targeting IL-1 and IL-6 appear to be effective especiall... BeFree,GAD,RGD 26487500 Detail
0.008 anterior uveitis NA BeFree,GAD,LHGDN Detail
0.002 Varicose Ulcer NA GAD Detail
0.123 Vascular Diseases NA BeFree,CTD_human,GAD Detail
0.005 vasculitis NA BeFree,GAD Detail
0.003 Vesico-Ureteral Reflux NA BeFree,GAD Detail
<0.001 viral hepatitis NA BeFree Detail
0.002 Viremia NA GAD Detail
0.010 Virus Diseases The pre-treatment of HeLa monolayer with inactivated bacterial cells 24 hours be... BeFree 26193210 Detail
0.007 vitiligo The combination of tumour necrosis factor-α -308A and interleukin-10 -1082G gene... BeFree,GAD 25283497 Detail
<0.001 intestinal volvulus Isolated PBMCs from O. volvulus-infected individuals (164 MF(+) and 46 a-MF) and... BeFree 25889652 Detail
0.001 Wasting Syndrome NA BeFree Detail
0.122 Weight Gain NA CTD_human,GAD Detail
0.002 Wheezing NA BeFree Detail
<0.001 Yersinia infections NA BeFree Detail
<0.001 Zollinger-Ellison syndrome NA BeFree Detail
0.120 Fibromatosis, Aggressive NA CTD_human Detail
<0.001 epidermolysis bullosa dystrophica Conversely, tumor necrosis factor-α was significantly decreased in DEB (P = 0.00... BeFree 26496255 Detail
0.080 Helicobacter Infections NA GAD Detail
<0.001 Ichthyosis, X-Linked NA BeFree Detail
0.010 B-Cell Lymphomas B-cell activating factor-receptor specific activation of tumor necrosis factor r... BeFree,GAD,LHGDN 24206092 Detail
0.008 diffuse large B-cell lymphoma NA BeFree,GAD Detail
0.004 Lymphoma, Large-Cell, Follicular NA BeFree Detail
<0.001 Low Grade Lymphoma (neoplasm) NA BeFree Detail
0.002 T-Cell Lymphoma NA BeFree Detail
0.003 Lymphoma, T-Cell, Cutaneous NA BeFree,LHGDN Detail
<0.001 peripheral T-cell lymphoma NA BeFree Detail
<0.001 Pleural Effusion, Malignant NA BeFree Detail
0.002 Disorder of the genitourinary system NA GAD Detail
0.002 Fungemia NA GAD Detail
0.005 Peripheral Vascular Diseases NA BeFree,GAD Detail
0.002 severe combined immunodeficiency Moreover, knockdown of tmTNF-α(+) expression rendered leukemia cells more sensit... BeFree 26224647 Detail
0.013 Bronchial Hyperreactivity NA BeFree,GAD Detail
0.006 bacterial vaginosis NA BeFree,GAD Detail
0.002 Neoplasms, Second Primary NA GAD Detail
0.026 gestational diabetes NA BeFree,GAD,LHGDN Detail
0.003 Ovarian Failure, Premature NA BeFree,GAD Detail
0.002 erythema infectiosum NA GAD Detail
0.003 antiphospholipid syndrome NA BeFree,GAD Detail
<0.001 hepatitis E NA BeFree Detail
0.003 Polyendocrinopathies, Autoimmune The ability of PGA to induce TNF-α and IL-6 was retained in TLR4(-/-) but not TL... BeFree,GAD 26195551 Detail
<0.001 Polycystic Kidney, Autosomal Dominant NA BeFree Detail
0.003 Arthritis, Reactive NA BeFree,GAD Detail
<0.001 palindromic rheumatism NA BeFree Detail
0.001 essential hypertension NA BeFree Detail
0.001 Encephalopathies NA BeFree Detail
<0.001 Chills NA BeFree Detail
0.005 Liver failure NA BeFree,GAD Detail
<0.001 pyoderma gangrenosum NA BeFree Detail
0.125 polymyositis NA BeFree,CTD_human,LHGDN Detail
0.001 acute leukemia To characterize tmTNF-α expression in acute leukemia (AL), normal hematopoietic ... BeFree 26224647 Detail
<0.001 Chronic gastritis NA BeFree Detail
0.003 Alcohol abuse Alcohol abuse promotes the migration of bone marrow-derived cells (BMDCs) to the... BeFree,GAD 25356030 Detail
0.003 Hamman-Rich syndrome NA BeFree,GAD Detail
<0.001 Idiopathic Membranous Glomerulonephritis NA BeFree Detail
<0.001 Ileal Pouches NA BeFree Detail
<0.001 Sicca Syndrome NA BeFree Detail
0.001 Chronic sinusitis NA BeFree Detail
0.018 Pancreatitis, Chronic Recent evidence suggests that both NOX1 and DUOX2 species produce ROS in the gas... BeFree,GAD,LHGDN 25818486 Detail
<0.001 congenital heart block NA BeFree Detail
0.003 Epstein-Barr Virus Infections The levels of inflammatory cytokines IL-6, IL-8, IL-1β and TNF-α in the HNE2 cel... BeFree,GAD 25891128 Detail
0.003 Left Ventricular Hypertrophy NA BeFree,GAD Detail
0.003 Oral Ulcer NA BeFree,GAD Detail
<0.001 Squamous cell carcinoma of lung NA BeFree Detail
<0.001 Humoral hypercalcemia of malignancy (disorder) NA BeFree Detail
0.002 Small cell carcinoma of lung NA BeFree Detail
<0.001 obstructive nephropathy NA BeFree Detail
0.080 sciatic neuropathy NA RGD Detail
<0.001 Adenocarcinoma of rectum NA BeFree Detail
<0.001 Sensory neuropathy Role of TNF block genetic variants in HIV-associated sensory neuropathy in black... BeFree 24896147 Detail
<0.001 Active tuberculosis NA BeFree Detail
0.046 Premature Birth NA GAD,LHGDN Detail
<0.001 Oral Cavity Carcinoma NA BeFree Detail
<0.001 renal fibrosis These include strategies targeting chemokine pathways via CC chemokine receptors... BeFree 25176603 Detail
0.007 Intracranial Hemorrhages NA GAD,LHGDN Detail
0.131 Myocardial Ischemia NA BeFree,CTD_human,GAD,LHGDN Detail
<0.001 Cutaneous Melanoma We found an association between the risk of CMM and peripheral blood mononuclear... BeFree 25026000 Detail
<0.001 Coronary Occlusion NA BeFree Detail
<0.001 Dry skin NA BeFree Detail
0.002 Adenocarcinoma of lung (disorder) We retrospectively compared the efficacy of standard platinum‑based chemotherapy... BeFree 25573239 Detail
<0.001 esophageal carcinoma Taken together, our data indicate that RIPK3 and autocrine production of TNFα co... BeFree 24959694 Detail
0.002 retinal vasculitis NA GAD Detail
<0.001 Echinococcus granulosus infection NA BeFree Detail
<0.001 lingual-facial-buccal dyskinesia NA BeFree Detail
0.003 low tension glaucoma NA BeFree,GAD Detail
<0.001 Idiopathic pulmonary hypertension NA BeFree Detail
<0.001 Chronic glomerulonephritis NA BeFree Detail
0.005 Malignant neoplasm of mouth NA BeFree,GAD Detail
<0.001 Malignant neoplasm of gallbladder NA BeFree Detail
<0.001 Malignant tumor of peritoneum NA BeFree Detail
0.002 Malignant neoplasm of testis NA GAD Detail
<0.001 Secondary malignant neoplasm of lung Anti-tumor necrosis factor therapy inhibits lung metastasis in an osteosarcoma c... BeFree 25402182 Detail
0.003 Lipid Metabolism Disorders NA BeFree,GAD Detail
<0.001 migraine with aura NA BeFree Detail
<0.001 proliferative diabetic retinopathy The -308G>a polymorphism of the TNF gene is associated with proliferative diabet... BeFree 25634985 Detail
0.001 Corneal pannus NA BeFree Detail
0.004 acute myocardial infarction We confirmed that the plasma sP‑selectin levels were increased in patients with ... BeFree 25384966 Detail
<0.001 Old myocardial infarction NA BeFree Detail
<0.001 acute myocarditis NA BeFree Detail
0.002 allergic asthma NA BeFree Detail
<0.001 Uterine Polyp NA BeFree Detail
<0.001 Chronic skin ulcer NA BeFree Detail
<0.001 Intervertebral disc disorder NA BeFree Detail
0.001 Intervertebral Disc Degeneration LIM mineralization protein-1 suppresses TNF-α induced intervertebral disc degene... BeFree 25336289 Detail
0.001 Intervertebral Disc Degeneration We investigated whether expression of xylosyltransferase-1 (XT-1), a key enzyme ... BeFree 25476526 Detail
0.001 Intervertebral Disc Degeneration To examine whether electroacupuncture (EA) treatment inhibited cell apoptosis of... BeFree 25618973 Detail
0.001 Intervertebral Disc Degeneration We propose that during disc degeneration PHD2 may offer a therapeutic target to ... BeFree 25635047 Detail
<0.001 Congenital cytomegalovirus infection NA BeFree Detail
0.003 adrenoleukodystrophy NA BeFree Detail
0.003 iron deficiency anemia NA BeFree,GAD Detail
0.002 Polyarthritis A standardized femur fracture was applied to wild type and human TNF-α transgeni... BeFree 24885217 Detail
0.002 Polyarthritis Spontaneous retrotransposon insertion into TNF 3'UTR causes heart valve disease ... BeFree 26195802 Detail
0.002 Contact hypersensitivity NA GAD Detail
0.001 Christ-Siemens-Touraine syndrome NA BeFree Detail
<0.001 Malnutrition NA BeFree Detail
0.007 AIDS-Related Opportunistic Infections NA GAD Detail
<0.001 Immunoglobulin A deficiency (disorder) NA BeFree Detail
0.210 Liver Failure, Acute NA BeFree,CTD_human,GAD,LHGDN,RGD Detail
<0.001 acute intermittent porphyria NA BeFree Detail
0.120 Mitochondrial Myopathies NA CTD_human Detail
0.003 HELLP syndrome NA BeFree,GAD Detail
<0.001 Cicatrix, Hypertrophic NA BeFree Detail
0.132 Dermatitis, Allergic Contact NA BeFree,CTD_human,GAD,LHGDN Detail
0.008 Dermatitis, Irritant NA BeFree,GAD Detail
<0.001 hidradenitis suppurativa NA BeFree Detail
0.003 Aneurysm, Ruptured NA BeFree,GAD Detail
0.007 Aortic Aneurysm, Abdominal NA GAD Detail
0.002 Aortic Aneurysm, Thoracic NA GAD Detail
<0.001 Autoimmune thyroid disease Polymorphisms in the TNFA and IL6 genes represent risk factors for autoimmune th... BeFree 25127106 Detail
<0.001 Glomerulosclerosis (disorder) NA BeFree Detail
0.008 Tumor Progression Tumor necrosis factor-α-inducible protein-1 (TNFAIP1) plays a role in DNA synthe... BeFree 24969828 Detail
0.008 Tumor Progression The ability of tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK... BeFree 25622756 Detail
0.008 Tumor Progression The tomato diet significantly inhibited TNFα stimulated NF-κB activity in cultur... BeFree 25664890 Detail
0.008 Tumor Progression TRAF4, or tumor necrosis factor receptor-associated factor 4, is overexpressed i... BeFree 25700355 Detail
<0.001 Infections, Hospital NA BeFree Detail
<0.001 Diabetes, Autoimmune NA BeFree Detail
<0.001 Dysplastic Nevus In control participants, the risk of developing dysplastic nevi was associated w... BeFree 25026000 Detail
<0.001 HIV Encephalopathy NA BeFree Detail
<0.001 Pneumonia, Interstitial NA BeFree Detail
0.006 Lung Diseases, Interstitial NA BeFree,GAD Detail
0.005 Periodontal Attachment Loss NA BeFree,GAD Detail
0.018 Lichen Planus, Oral TNF-α, TNF-β and IL-10 gene polymorphism and association with oral lichen planus... BeFree,GAD,LHGDN 26221924 Detail
<0.001 Eosinophilic leukemia NA BeFree Detail
0.120 myocardial stunning NA CTD_human Detail
0.002 Community-Acquired Infections NA GAD Detail
<0.001 Diabetic Foot Genetic association of IL-6, TNF-α and SDF-1 polymorphisms with serum cytokine l... BeFree 25839939 Detail
0.005 Cytomegalovirus retinitis NA BeFree,GAD Detail
0.002 Ki-1+ Anaplastic Large Cell Lymphoma NA BeFree Detail
0.003 exfoliation syndrome NA BeFree,GAD Detail
0.120 Cardiovirus Infections NA CTD_human Detail
0.002 hepatoblastoma NA BeFree Detail
<0.001 Giant Cell Tumor of Bone NA BeFree Detail
<0.001 embryonal carcinoma NA BeFree Detail
<0.001 Neuroectodermal Tumor, Primitive The aim of our study was to analyze TNF-α promoter gene polymorphisms as risk fa... BeFree 25213764 Detail
<0.001 Medullary carcinoma NA BeFree Detail
0.003 cholangiocarcinoma ALCAM is a Novel Cytoplasmic Membrane Protein in TNF-α Stimulated Invasive Chola... BeFree 25987048 Detail
<0.001 Carcinoma, Large Cell NA BeFree Detail
0.006 Cervical Intraepithelial Neoplasia NA BeFree,GAD Detail
0.002 Alphavirus Infections NA GAD Detail
0.005 Neuroendocrine Tumors NA BeFree,GAD,LHGDN Detail
<0.001 uveal melanoma NA BeFree Detail
0.002 Lip and oral cavity carcinoma NA BeFree Detail
<0.001 Metastatic malignant neoplasm to brain These findings suggest that miR-509 has a critical role in brain metastasis of b... BeFree 25659578 Detail
<0.001 Malignant ascites NA BeFree Detail
<0.001 Reactive systemic amyloidosis NA BeFree Detail
<0.001 Chronic berylliosis NA BeFree Detail
0.004 Adult type dermatomyositis Associations between TNF-α-308A/G polymorphism and susceptibility with dermatomy... BeFree 25101759 Detail
<0.001 Diplegia NA BeFree Detail
0.125 Lytic lesion NA CTD_human,GAD Detail
<0.001 Tophus NA BeFree Detail
<0.001 Trichiasis NA BeFree Detail
<0.001 Hydrosalpinx (disease) NA BeFree Detail
<0.001 Lesion of brain NA BeFree Detail
<0.001 Morning stiffness (>1 hour) NA BeFree Detail
<0.001 chronic cystitis NA BeFree Detail
<0.001 Chronic schizophrenia NA BeFree Detail
<0.001 nontoxic goiter NA BeFree Detail
<0.001 Myalgia NA BeFree Detail
0.001 Memory impairment NA BeFree Detail
<0.001 Extrapyramidal sign NA BeFree Detail
<0.001 Retinal damage Since TNFα and IGFBP-3 are key mediators of retinal damage and protection respec... BeFree 25073020 Detail
<0.001 Heart Failure, Right-Sided NA BeFree Detail
0.002 gallbladder carcinoma NA BeFree Detail
<0.001 Cerebral atrophy NA BeFree Detail
0.010 pancreatic carcinoma Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induc... BeFree 24675460 Detail
0.010 pancreatic carcinoma The aim of our study was to analyze TNF-α promoter gene polymorphisms as risk fa... BeFree 25213764 Detail
0.010 pancreatic carcinoma Recent evidence suggests that both NOX1 and DUOX2 species produce ROS in the gas... BeFree 25818486 Detail
0.002 Substance-Related Disorders NA GAD Detail
<0.001 Colitis, Collagenous NA BeFree Detail
0.003 Cancer of Nasopharynx NA BeFree,GAD Detail
<0.001 Anaplastic thyroid carcinoma NA BeFree Detail
0.001 Papillary thyroid carcinoma NA BeFree Detail
0.004 bone destruction TNF-α is expressed in human cherubism lesions, which contain a large number of t... BeFree 24916406 Detail
0.004 bone destruction To investigate the expression of TNF-α, IFN-γ, TGF-β, and IL-4 in the spinal tub... BeFree 25326857 Detail
0.004 bone destruction Loss of SH3 domain-binding protein 2 function suppresses bone destruction in tum... BeFree 25470448 Detail
0.004 bone destruction Tumor necrosis factor (TNF) drives bone destruction, but it also inhibits new bo... BeFree 25941031 Detail
0.003 Fibrosis, Liver Synergistic effect of pro-inflammatory TNFα and IL-17 in periostin mediated coll... BeFree 25467797 Detail
<0.001 Hypoalbuminemia NA BeFree Detail
<0.001 Interstitial fibrosis NA BeFree Detail
<0.001 Iron deficiency NA BeFree Detail
0.008 Hepatitis, Autoimmune NA BeFree,GAD Detail
<0.001 Pulmonary congestion The consequence of VILI by H&E stain showed inducing lung congestion and increas... BeFree 25815839 Detail
0.003 Biliary calculi NA LHGDN Detail
0.005 coronary stenosis NA GAD Detail
0.007 Dyslipidemias Our study validates the association of the TNF-α 238G/A SNP allelic variant with... BeFree,GAD,LHGDN 25439236 Detail
0.007 Dyslipidemias Furthermore, the homeostasis model assessment of insulin resistance (HOMA-IR) in... BeFree,GAD,LHGDN 26264374 Detail
0.042 Malignant neoplasm of lung Expression of tumor necrosis factor-alpha-mediated genes predicts recurrence-fre... BeFree,GAD 25548907 Detail
0.042 Malignant neoplasm of lung Meta-analysis of the associations between TNF-α or IL-6 gene polymorphisms and s... BeFree,GAD 25889486 Detail
0.001 age related macular degeneration NA BeFree Detail
<0.001 Parkinsonian Disorders NA BeFree Detail
<0.001 Sore Throat NA BeFree Detail
0.082 Acute Lung Injury NA GAD,RGD Detail
<0.001 Neoplasm, Residual NA BeFree Detail
0.002 Oxidative Stress NA GAD Detail
0.006 Mucosa-Associated Lymphoid Tissue Lymphoma NA BeFree,GAD,LHGDN Detail
0.005 Disease Progression NA GAD,LHGDN Detail
0.002 Ventricular Dysfunction, Left NA GAD Detail
0.003 Hyperoxia NA LHGDN Detail
0.011 Parasitemia NA BeFree,GAD,LHGDN Detail
<0.001 Bronchiolitis Obliterans Organizing Pneumonia NA BeFree Detail
0.002 Breast Neoplasms, Male NA GAD Detail
0.003 Proliferative vitreoretinopathy NA BeFree,GAD Detail
0.017 Systemic Inflammatory Response Syndrome Furthermore, Sirt2−/− mice succumbed to TNF induced Systemic Inflammatory Respon... BeFree,GAD,LHGDN 24572428 Detail
0.120 Ventricular Dysfunction NA CTD_human Detail
0.001 nephropathia epidemica NA BeFree Detail
0.009 Hantavirus Infections NA BeFree,GAD,LHGDN Detail
<0.001 Abdominal Abscess NA BeFree Detail
0.002 hantavirus pulmonary syndrome NA GAD Detail
0.286 Sepsis Toll-like receptors (TLR) recognize pathogens and trigger the production of vigo... BeFree,CTD_human,GAD,LHGDN,RGD 24758719 Detail
0.286 Sepsis TNF-α, IL-6, and IL-8 cytokines and their association with TNF-α-308 G/A polymor... BeFree,CTD_human,GAD,LHGDN,RGD 24944154 Detail
0.286 Sepsis The protection of female hearts against the dysfunction associated with sepsis i... BeFree,CTD_human,GAD,LHGDN,RGD 24945834 Detail
0.286 Sepsis In summary, this work provides the first in vivo evidence that administering BMM... BeFree,CTD_human,GAD,LHGDN,RGD 25337817 Detail
0.286 Sepsis Modulation of TNF-α mRNA stability by human antigen R and miR181s in sepsis-indu... BeFree,CTD_human,GAD,LHGDN,RGD 25535255 Detail
0.286 Sepsis Shedding of the tumor necrosis factor (TNF) receptor from the surface of hepatoc... BeFree,CTD_human,GAD,LHGDN,RGD 25628461 Detail
<0.001 Atresia This study evaluated the relationship between single-nucleotide polymorphisms in... BeFree 25047315 Detail
<0.001 Collagen-vascular disease NA BeFree Detail
<0.001 Psoriasiform eczema NA BeFree Detail
<0.001 pemphigus foliaceus NA BeFree Detail
0.004 Psoriasis vulgaris TNF-like ligand 1A is associated with the pathogenesis of psoriasis vulgaris and... BeFree 25200589 Detail
<0.001 Epithelial hyperplasia of skin NA BeFree Detail
0.002 Dermatomyositis, Childhood Type NA BeFree Detail
<0.001 Acute arthritis NA BeFree Detail
<0.001 Osteoarthritis of the hand Variations in the TNFα gene and their interactions with the IL4R and IL10 genes ... BeFree 25252624 Detail
<0.001 Acute upper respiratory infection NA BeFree Detail
0.003 Childhood asthma NA BeFree Detail
<0.001 Asthma, Occupational NA BeFree Detail
<0.001 Acute respiratory failure NA BeFree Detail
0.001 Chronic heart failure NA BeFree Detail
0.016 Chronic Periodontitis Analysis of TNF-α (-308) polymorphism and gingival crevicular fluid TNF-α levels... BeFree,GAD,LHGDN 25647273 Detail
<0.001 Vesicular Stomatitis Since pDC, but not cDC, from pearl mice showed an impaired IFN-α and tumor necro... BeFree 25333950 Detail
<0.001 Crohn's disease of the ileum NA BeFree Detail
0.120 Cholestasis of pregnancy NA BeFree,CTD_human Detail
<0.001 Systemic amyloidosis NA BeFree Detail
<0.001 Amyloid nephropathy NA BeFree Detail
0.001 Muckle-Wells syndrome NA BeFree Detail
<0.001 Isovaleryl-CoA dehydrogenase deficiency NA BeFree Detail
<0.001 Simple renal cyst NA BeFree Detail
<0.001 Vulvar Vestibulitis NA BeFree Detail
<0.001 Endometrioma NA BeFree Detail
<0.001 Induration of breast NA BeFree Detail
<0.001 Limb-girdle muscular dystrophy type 2H NA BeFree Detail
<0.001 Rhegmatogenous retinal detachment NA BeFree Detail
<0.001 Eales disease NA BeFree Detail
<0.001 Exudative age-related macular degeneration Early and exudative age-related macular degeneration is associated with increase... BeFree 25363549 Detail
<0.001 Visual halos (disorder) NA BeFree Detail
<0.001 Acute otitis media NA BeFree Detail
0.004 Impaired glucose tolerance NA BeFree,GAD Detail
<0.001 beta^0^ Thalassemia NA BeFree Detail
<0.001 Severe hereditary factor VIII deficiency disease NA BeFree Detail
0.120 Lung Injury NA CTD_human Detail
<0.001 Clinical infection NA BeFree Detail
<0.001 Asymptomatic Infections NA BeFree Detail
0.001 Coinfection NA BeFree Detail
<0.001 Primary bacterial peritonitis The two-week JWH133 treatment significantly decreased systemic/intestinal oxidat... BeFree 24953022 Detail
<0.001 Viral myocarditis NA BeFree Detail
<0.001 Canarypox (disorder) NA BeFree Detail
<0.001 Herpes encephalitis NA BeFree Detail
0.002 Disease due to Parvoviridae NA GAD Detail
0.003 Respiratory syncytial virus bronchiolitis NA BeFree,GAD Detail
<0.001 HIV encephalitis NA BeFree Detail
<0.001 Acute viral hepatitis NA BeFree Detail
<0.001 Infection by Candida albicans NA BeFree Detail
<0.001 Absence of sensation NA BeFree Detail
<0.001 Carcinoma breast stage IV NA BeFree Detail
<0.001 Metastatic osteosarcoma The effect of infliximab, a TNF-α inhibitor, on a metastatic osteosarcoma 143B c... BeFree 25402182 Detail
0.002 gastric adenocarcinoma The purpose of this study was to identify functional genetic variants in the pro... BeFree 25251497 Detail
0.002 gastric adenocarcinoma To investigate the role of claudin 1 in the regulation of genes involved in cell... BeFree 25548484 Detail
<0.001 Malignant Childhood Neoplasm NA BeFree Detail
<0.001 recurrent Wilms' tumor and other childhood kidney tumors NA BeFree Detail
<0.001 Metastatic melanoma NA BeFree Detail
0.006 Cancer of Head and Neck NA BeFree,GAD Detail
0.001 Liver and Intrahepatic Biliary Tract Carcinoma NA BeFree Detail
<0.001 Philadelphia chromosome positive chronic myelogenous leukemia NA BeFree Detail
0.001 Squamous cell carcinoma of esophagus NA BeFree Detail
0.001 Adenocarcinoma Of Esophagus NA BeFree Detail
<0.001 Conventional (Clear Cell) Renal Cell Carcinoma Expression of TNF-α and CD44 is implicated in poor prognosis, cancer cell invasi... BeFree 25123505 Detail
<0.001 Conventional (Clear Cell) Renal Cell Carcinoma CD70, a member of the TNF ligand superfamily, has been shown frequently overexpr... BeFree 25691774 Detail
0.002 Solid tumour A20, also known as tumor necrosis factor-α (TNFα)-induced protein 3 (TNFAIP3), h... BeFree 26159495 Detail
<0.001 Acute Undifferentiated Leukemia Transmembrane TNF-α preferentially expressed by leukemia stem cells and blasts i... BeFree 26224647 Detail
<0.001 stage, gastric cancer NA BeFree Detail
<0.001 Squamous cell carcinoma of oropharynx NA BeFree Detail
<0.001 laryngeal squamous cell carcinoma Association between laryngeal squamous cell carcinoma and polymorphisms in tumor... BeFree 25605161 Detail
<0.001 Adenocarcinoma of pancreas NA BeFree Detail
<0.001 Primary Systemic Amyloidosis NA BeFree Detail
<0.001 Prolapsed lumbar disc By contrast, upregulation of interleukin-2 (IL-2), IL-6, IL-8 and tumor necrosis... BeFree 25816023 Detail
0.003 Iron Overload NA BeFree,GAD Detail
<0.001 leukostasis NA BeFree Detail
<0.001 Very Low Birth Weight NA BeFree Detail
0.001 Infant, Very Low Birth Weight NA BeFree Detail
<0.001 Hemorrhagic Fever, Ebola NA BeFree Detail
<0.001 Disease caused by Shigella dysenteriae NA BeFree Detail
<0.001 Brucella melitensis infection NA BeFree Detail
0.019 cervix carcinoma Re-expression of HPV16 E2 in SiHa (human cervical cancer) cells potentiates NF-κ... BeFree,GAD 25572145 Detail
0.019 cervix carcinoma TNF-α -308 G/A as a risk marker of cervical cancer progression in the Polish pop... BeFree,GAD 25614219 Detail
0.001 Fulminant hepatitis Administration of antagonists against C5aR or TNF-α ameliorated MHV-3-induced FH... BeFree 25200905 Detail
<0.001 Uremia syndrome NA BeFree Detail
<0.001 Obesity, Abdominal Linear regression analysis of the parameters with body mass index (BMI) and meta... BeFree 25478993 Detail
0.120 Arsenic Poisoning NA CTD_human Detail
<0.001 Anastomosis NA BeFree Detail
0.003 Restenosis NA BeFree,GAD Detail
0.004 Superficial ulcer Loss of FAK reduced invasion in murine arthritic synovial fibroblasts, but not m... BeFree 25280866 Detail
0.004 Superficial ulcer Therefore, global and CMV (NLV)-specific CD8(+) T cells that secrete interferon-... BeFree 25314332 Detail
0.001 Senile Plaques NA BeFree Detail
0.009 Tumor necrosis Homozygosity for the TNFR1A 36A allele and the TNFA-875T variant could act as a ... BeFree 25311255 Detail
0.009 Tumor necrosis To this end, we identified TNBC-driven molecular pathways such as the Janus kina... BeFree 25611337 Detail
0.009 Tumor necrosis The tumor necrosis factor (TNF) signaling pathway is a classical immune system p... BeFree 25912078 Detail
0.009 Tumor necrosis Using anti-TNF treatment and TNF-receptor-deficient mice, here we show that Bin ... BeFree 25959608 Detail
0.007 Atrophic NA GAD Detail
<0.001 Squamous intraepithelial lesion NA BeFree Detail
<0.001 High-Grade Squamous Intraepithelial Lesions NA BeFree Detail
<0.001 malignant fibrous histiocytoma NA BeFree Detail
<0.001 Arteriovenous hemangioma NA BeFree Detail
<0.001 pilocytic astrocytoma NA BeFree Detail
<0.001 anaplastic oligodendroglioma NA BeFree Detail
<0.001 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse NA BeFree Detail
<0.001 Adenocarcinoma of colon NA BeFree Detail
0.009 Common Migraine NA BeFree,GAD,LHGDN Detail
<0.001 familial hemiplegic migraine NA BeFree Detail
<0.001 Impaired cognition NA BeFree Detail
0.011 Thyroid associated opthalmopathies NA BeFree,GAD Detail
<0.001 Venous retinal branch occlusion NA BeFree Detail
0.002 Glaucoma, Primary Open Angle NA BeFree Detail
<0.001 Lofgrens syndrome NA BeFree Detail
<0.001 Simple pneumoconiosis NA BeFree Detail
<0.001 Complicated pneumoconiosis NA BeFree Detail
0.121 Stable angina The frequency of circulating CD14(+)HLA-DR(-/low) MDSCs; arginase-1 (Arg-1) expr... BeFree,CTD_human 25591771 Detail
<0.001 Anterior myocardial infarction NA BeFree Detail
<0.001 Q fever endocarditis NA BeFree Detail
<0.001 Arteriovenous fistula thrombosis Association of TNF-α -308 G > A and ACE I/D gene polymorphisms in hemodialysis p... BeFree 24126814 Detail
<0.001 Indeterminate colitis NA BeFree Detail
<0.001 Cytomegaloviral colitis NA BeFree Detail
0.001 Chronic liver disease NA BeFree Detail
<0.001 endometriosis of uterus NA BeFree Detail
<0.001 Hypothyroidism, Autoimmune NA BeFree Detail
0.010 Complications of Diabetes Mellitus NA GAD,LHGDN Detail
<0.001 Idiopathic hirsutism We aimed to determine mRNA expressions of genes associated with local androgen s... BeFree 26194504 Detail
<0.001 Malonic aciduria NA BeFree Detail
0.003 Generalized pustular psoriasis NA BeFree,GAD Detail
<0.001 Familial cold urticaria NA BeFree Detail
<0.001 Microscopic Polyangiitis NA BeFree Detail
<0.001 Helicobacter-associated gastritis NA BeFree Detail
<0.001 Clostridium difficile infection NA BeFree Detail
<0.001 Borderline lepromatous leprosy NA BeFree Detail
<0.001 Erythema nodosum leprosum NA BeFree Detail
0.120 HIV Wasting Syndrome NA BeFree,CTD_human Detail
<0.001 Absence of pain sensation NA BeFree Detail
0.004 Malignant neoplasm of liver NA BeFree,GAD Detail
<0.001 malignant mesothelioma NA BeFree Detail
0.011 Malignant neoplasm of pancreas Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induc... BeFree,GAD 24675460 Detail
0.011 Malignant neoplasm of pancreas The aim of our study was to analyze TNF-α promoter gene polymorphisms as risk fa... BeFree,GAD 25213764 Detail
<0.001 Disseminated Malignant Neoplasm NA BeFree Detail
<0.001 Early gastric cancer NA BeFree Detail
<0.001 Squamous cell carcinoma of tongue In this study, we explored whether human gingival-derived MSCs (G-MSCs) can migr... BeFree 25391621 Detail
<0.001 juvenile myelomonocytic leukemia NA BeFree Detail
<0.001 Ischemic myocardial dysfunction NA BeFree Detail
<0.001 Ischemic cardiomyopathy NA BeFree Detail
<0.001 prediabetes syndrome NA BeFree Detail
0.009 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site To investigate the expression level of tumor necrosis factor receptor-associated... BeFree 24852885 Detail
0.009 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site Moreover, the activating effect of TNF-α was markedly augmented by the infection... BeFree 25008775 Detail
<0.001 Human T-cell lymphotrophic virus, type I [HTLV-I] NA BeFree Detail
0.004 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site NA BeFree Detail
<0.001 Hantavirus infection in conditions classified elsewhere and of unspecified site NA BeFree Detail
<0.001 Malignant neoplasm of vulva NA BeFree Detail
<0.001 Skin callus High levels of TNF-α influence fracture healing negatively, lead to reduced cart... BeFree 24885217 Detail
<0.001 dengue shock syndrome A protective association of TNF-α -308A allele and -308GA genotype against DHF/D... BeFree 25589894 Detail
0.037 Malignant neoplasm of prostate The NRIF3/DIF-1/FASTKD2 pathway acts as a death switch in breast and prostate ca... BeFree,GAD 25409762 Detail
0.037 Malignant neoplasm of prostate Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-Troglitazone-ind... BeFree,GAD 26198640 Detail
0.011 Hematologic Neoplasms APRIL (a proliferation-inducing ligand) is a cytokine of the tumor necrosis fact... BeFree,GAD,LHGDN 25750171 Detail
0.085 Endotoxemia NA GAD,RGD Detail
0.003 Pouchitis NA BeFree,GAD Detail
0.002 Pancreatitis, Alcoholic NA GAD Detail
<0.001 cardiac sarcoidosis Relationship between tumor necrosis factor-α (TNFA) gene polymorphisms and cardi... BeFree 25398810 Detail
<0.001 Hereditary hemochromatosis NA BeFree Detail
0.002 Postoperative infection NA GAD Detail
0.005 Atopy NA GAD Detail
<0.001 Vacuolar myelopathy NA BeFree Detail
0.003 multiple system atrophy NA BeFree,GAD Detail
0.002 Multiple Sclerosis, Chronic Progressive NA GAD Detail
0.005 thrombophilia NA BeFree,GAD Detail
0.006 Immune thrombocytopenic purpura Tumor necrosis factor-α -308G/A gene polymorphism in Egyptian children with immu... BeFree,GAD 24509339 Detail
0.006 Immune thrombocytopenic purpura TNF-α promoter single nucleotide polymorphisms and haplotypes associate with sus... BeFree,GAD 25158149 Detail
0.002 Hyperimmunoglobulinemia D NA BeFree Detail
<0.001 Early onset periodontitis NA BeFree Detail
0.003 Colitis, Microscopic NA BeFree,GAD Detail
<0.001 Autoimmune liver disease NA BeFree Detail
0.004 Non-alcoholic Fatty Liver Disease In addition, decreased numbers of CD4+ and CD8+ T lymphocytes and increased leve... BeFree 25644696 Detail
0.004 Non-alcoholic Fatty Liver Disease Serum levels of interleukin 8, chemokine (C-C motif) ligand 3, and tumor necrosi... BeFree 26028579 Detail
<0.001 Steroid-sensitive nephrotic syndrome NA BeFree Detail
<0.001 Idiopathic crescentic glomerulonephritis NA BeFree Detail
0.001 Chronic Kidney Insufficiency NA BeFree Detail
0.080 Anti-Glomerular Basement Membrane Disease NA RGD Detail
<0.001 Congenital bilateral aplasia of vas deferens NA BeFree Detail
0.002 asthenozoospermia NA GAD Detail
<0.001 Chronic pelvic pain of female NA BeFree Detail
0.002 Nuchal Cord NA GAD Detail
<0.001 Chronic small plaque psoriasis NA BeFree Detail
<0.001 Seropositive rheumatoid arthritis NA BeFree Detail
<0.001 Undifferentiated inflammatory oligoarthritis NA BeFree Detail
<0.001 Osteoarthritis of distal interphalangeal joint Variations in the TNFα gene and their interactions with the IL4R and IL10 genes ... BeFree 25252624 Detail
0.006 Osteoarthritis, Knee Meta-analysis of tumor necrosis factor alpha -308 polymorphism and knee osteoart... BeFree,GAD 25398219 Detail
0.020 lupus erythematosus Since chronic local activation of proinflammatory cytokines including TNF-α in r... BeFree,GAD 24627031 Detail
<0.001 Neonatal Systemic lupus erythematosus NA BeFree Detail
<0.001 Congenital Myotonic Dystrophy NA BeFree Detail
0.002 Cutaneous Fistula NA GAD Detail
0.002 Fever symptoms (finding) NA GAD Detail
<0.001 Arthritis by pattern of joint involvement NA BeFree Detail
<0.001 Aortic valve calcification NA BeFree Detail
0.001 Ichthyosis bullosa of Siemens NA BeFree Detail
<0.001 Post-transplant lymphoproliferative disorder NA BeFree Detail
<0.001 Fatigue - symptom NA BeFree Detail
0.002 neuropathy Here we investigated genetic associations with HIV-SN in 342 black Southern Afri... BeFree 24896147 Detail
0.002 neuropathy Receiver operating characteristics (ROC) analysis revealed that TNF-α had great ... BeFree 25847150 Detail
<0.001 Non-obstructive reflux-associated chronic pyelonephritis (disorder) NA BeFree Detail
<0.001 endometrial carcinoma NA BeFree Detail
0.002 Dermatitis and eczema NA GAD Detail
<0.001 Human anaplasmosis due to Anaplasma phagocytophilum NA BeFree Detail
<0.001 Secondary malignant neoplasm of liver NA BeFree Detail
<0.001 Alzheimer Disease, Late Onset Thus, circadian rhythms, nest construction, IL-1β and TNF-α, and glial fibrillar... BeFree 25159669 Detail
<0.001 hiv-infection/aids NA BeFree Detail
0.016 dementia NA BeFree,GAD,LHGDN Detail
0.010 Overweight Transcript levels of TNFα were significantly higher by 1.4-fold and 2.1-fold in ... BeFree,GAD 24961464 Detail
0.010 Overweight Tumor necrosis factor-alpha -308 G>A polymorphism, adherence to Mediterranean di... BeFree,GAD 25028665 Detail
0.010 Overweight The aim of the present study was to evaluate the potential association between d... BeFree,GAD 25340371 Detail
<0.001 Chlamydia trachomatis infection Human papillomavirus and chlamydia trachomatis infections in rheumatoid arthriti... BeFree 25348220 Detail
0.087 Necrotizing Enterocolitis NA BeFree,GAD,LHGDN,RGD Detail
<0.001 Chronic active hepatitis NA BeFree Detail
<0.001 Buffalo hump NA BeFree Detail
0.015 Sleep Apnea, Obstructive An updated meta-analysis of the association between tumor necrosis factor-α -308... BeFree,GAD,LHGDN 25222485 Detail
<0.001 Recurrent tumor NA BeFree Detail
<0.001 Granulomatosis NA BeFree Detail
<0.001 Decreased drug resistance NA BeFree Detail
0.022 Metabolic syndrome X Polymorphism at the TNF-alpha gene interacts with Mediterranean diet to influenc... BeFree,GAD 24753491 Detail
0.022 Metabolic syndrome X Association of polymorphisms in stress-related TNFα and NPY genes with the metab... BeFree,GAD 25081719 Detail
0.022 Metabolic syndrome X Linear regression analysis of the parameters with body mass index (BMI) and meta... BeFree,GAD 25478993 Detail
0.022 Metabolic syndrome X Association of tumor necrosis factor-α promoter G-308A gene polymorphism with in... BeFree,GAD 25967388 Detail
0.002 Neurodegenerative Disorders Apart from the well-known pharmacological effects of TNF inhibitors on autoimmun... BeFree 24998784 Detail
0.047 Hepatitis B, Chronic This study was performed to explore the relationships between the sequence varia... BeFree,GAD,LHGDN 25501140 Detail
0.066 Hepatitis C, Chronic The aim of this study was to assess whether two-years treatment with Pirfenidone... BeFree,GAD,LHGDN 25064094 Detail
<0.001 Schnitzler syndrome NA BeFree Detail
0.003 Mood Disorders NA BeFree,GAD Detail
<0.001 Mixed cryoglobulinemia NA BeFree Detail
<0.001 Fluid overload NA BeFree Detail
0.017 Malignant neoplasm of esophagus Taken together, our data indicate that RIPK3 and autocrine production of TNFα co... BeFree,GAD 24959694 Detail
<0.001 Recurrent Carcinoma NA BeFree Detail
0.001 Thyroid carcinoma NA BeFree Detail
<0.001 Alveolitis NA BeFree Detail
<0.001 Ewings sarcoma NA BeFree Detail
<0.001 Oropharyngeal disorders NA BeFree Detail
0.003 Malignant glioma NA BeFree Detail
<0.001 Obstetric disorders The role of tumor necrosis factor-α (TNF-α), a cytokine involved in inflammation... BeFree 25059926 Detail
0.004 primary sclerosing cholangitis NA BeFree,GAD Detail
<0.001 Drug-induced erythema multiforme NA BeFree Detail
<0.001 Chronic idiopathic urticaria Interleukin-6 and tumor necrosis factor-alpha gene polymorphisms in chronic idio... BeFree 24051251 Detail
<0.001 Cutaneous hypersensitivity NA BeFree Detail
<0.001 Minor oral aphthous ulceration NA BeFree Detail
0.006 Periodic syndrome NA BeFree Detail
0.003 Osteosarcoma of bone Tumor necrosis factor-related apoptosis-inducing ligand induces cytotoxicity spe... BeFree 25335093 Detail
0.003 Osteosarcoma of bone Anti-tumor necrosis factor therapy inhibits lung metastasis in an osteosarcoma c... BeFree 25402182 Detail
0.001 Aqueous Humor Disorders NA BeFree Detail
0.001 Carcinoma of larynx NA BeFree Detail
0.120 hyperhomocysteinemia NA CTD_human Detail
<0.001 Leukemogenesis NA BeFree Detail
<0.001 Tumor Initiation NA BeFree Detail
0.017 prostate carcinoma The NRIF3/DIF-1/FASTKD2 pathway acts as a death switch in breast and prostate ca... BeFree 25409762 Detail
0.017 prostate carcinoma Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-Troglitazone-ind... BeFree 26198640 Detail
0.002 toxic shock syndrome Using a matrigel invasion assay, we showed that TSS significantly attenuated inv... BeFree 25168152 Detail
0.002 hepatopulmonary syndrome NA GAD Detail
0.200 Neurogenic Inflammation NA CTD_human,RGD Detail
0.120 Manganese Poisoning NA CTD_human Detail
<0.001 CARCINOMA OF VULVA NA BeFree Detail
0.006 Hashimoto Disease A significant association was found between the allele A in TNFA-308 G/A and Has... BeFree,GAD 25127106 Detail
0.005 Epithelial ovarian cancer The effect of a TNFα-producing adipose tissue-derived MSC (AT-MSC/hTNFα) was tes... BeFree,GAD 25677845 Detail
<0.001 invasive cancer NA BeFree Detail
<0.001 Progressive Neoplastic Disease NA BeFree Detail
<0.001 Terminal Ileitis NA BeFree Detail
0.028 breast carcinoma Tumor necrosis factor receptor-associated factor 4 (TRAF4) is upregulated in var... BeFree 24990246 Detail
0.028 breast carcinoma To better understand the roles of single nucleotide polymorphisms (SNPs) in the ... BeFree 25010932 Detail
0.028 breast carcinoma Association between the tumor necrosis factor alpha gene -308G> A polymorphism a... BeFree 25149156 Detail
0.028 breast carcinoma Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can ind... BeFree 25150312 Detail
0.028 breast carcinoma The overexpression of CMTM1_v17 in the breast cancer cell line MDA-MB-231 promot... BeFree 25175386 Detail
0.028 breast carcinoma The important function of FASN in the drug tolerance of breast cancer may be due... BeFree 25292037 Detail
0.028 breast carcinoma In the current study we examined the expression and function of HOTAIR in MCF-7-... BeFree 25328122 Detail
0.028 breast carcinoma In conclusion, our findings support a contributing role of certain TNF-α and TLR... BeFree 25332681 Detail
0.028 breast carcinoma Tumor necrosis factor-α sensitizes breast cancer cells to natural products with ... BeFree 25419573 Detail
0.028 breast carcinoma TNFα was increased upon overexpression of miR562, which was reversed when ANXA1 ... BeFree 25536365 Detail
0.028 breast carcinoma NFKB1, NFKBIA, IL-8, IL-10, and TNF polymorphisms could serve as useful predicti... BeFree 25559835 Detail
0.028 breast carcinoma Melanoma A375 and breast carcinoma SKBR3 cells were the most sensitive, and thei... BeFree 25677845 Detail
0.028 breast carcinoma In this study, we examined protein arginine methyltransferase 5 (PRMT5) and tumo... BeFree 25704480 Detail
0.028 breast carcinoma By testing a panel of different cytokines, chemokines, growth factors and other ... BeFree 25900663 Detail
0.028 breast carcinoma Regulation of the inflammatory profile of stromal cells in human breast cancer: ... BeFree 25928089 Detail
<0.001 Tuberculosis, extrapulmonary NA BeFree Detail
<0.001 iron loading anemia NA BeFree Detail
<0.001 inflammatory joint disease NA BeFree Detail
0.011 Carcinoma of lung Allantopyrone A, a recently identified α-pyrone metabolite from an endophytic fu... BeFree 25118107 Detail
0.011 Carcinoma of lung Expression of tumor necrosis factor-alpha-mediated genes predicts recurrence-fre... BeFree 25548907 Detail
0.011 Carcinoma of lung In conclusion, TNF-α induced CLDN1 expression is regulated by the PKCδ-iPLA2-PGE... BeFree 25562426 Detail
0.011 Carcinoma of lung Meta-analysis of the associations between TNF-α or IL-6 gene polymorphisms and s... BeFree 25889486 Detail
<0.001 bacterial sepsis NA BeFree Detail
<0.001 Hemophilia, NOS NA BeFree Detail
<0.001 Ewings sarcoma-primitive neuroectodermal tumor (PNET) NA BeFree Detail
<0.001 Malignant neoplasm of muscle NA BeFree Detail
<0.001 Malignant neoplasm of gastrointestinal tract NA BeFree Detail
<0.001 Tardive Dyskinesia NA BeFree Detail
<0.001 CNS metastases New cytokine inhibitors targeting IL-1 and IL-6 appear to be effective especiall... BeFree 26487500 Detail
0.001 Secondary malignant neoplasm of lymph node NA BeFree Detail
0.005 Pregnancy loss NA GAD Detail
<0.001 Community acquired pneumonia NA BeFree Detail
<0.001 Excessive daytime somnolence NA BeFree Detail
<0.001 Infection of ear NA BeFree Detail
0.013 colon carcinoma In search for novel strategies in colon cancer treatment, we investigated the un... BeFree 25285768 Detail
0.013 colon carcinoma The effect of a TNFα-producing adipose tissue-derived MSC (AT-MSC/hTNFα) was tes... BeFree 25677845 Detail
0.019 stomach carcinoma Tumor necrosis factor-related apoptosis inducing ligand gene polymorphisms are c... BeFree,GAD 24277417 Detail
0.019 stomach carcinoma Association between TNF-α-308 G/A gene polymorphism and gastric cancer risk: a s... BeFree,GAD 25125137 Detail
0.019 stomach carcinoma Clinical study on gastric cancer susceptibility genes IL-10-1082 and TNF-α. BeFree,GAD 25526211 Detail
0.019 stomach carcinoma These results suggest that claudin 1 is an important messenger that regulates TN... BeFree,GAD 25548484 Detail
0.005 Carcinoma of bladder In this study, we investigated the effects and molecular mechanisms of metformin... BeFree 24714080 Detail
<0.001 skin carcinoma NA BeFree Detail
<0.001 airway disease NA BeFree Detail
0.007 Central neuroblastoma In the present study, the inflammatory cytokine, tumor necrosis factor‑α (TNF‑α)... BeFree 25503960 Detail
0.007 Central neuroblastoma TNFα sensitizes neuroblastoma cells to FasL-, cisplatin- and etoposide-induced c... BeFree 25890358 Detail
0.080 radiculopathy NA RGD Detail
<0.001 Anxiety state Variations in three cytokine genes (i.e., interleukin (IL) 1 beta, IL1 receptor ... BeFree 25249351 Detail
<0.001 Acute anterior uveitis NA BeFree Detail
0.002 acne NA BeFree Detail
<0.001 Dissecting aneurysm of the thoracic aorta In addition, apoA-I reversed the TNF-mediated suppression of lymphatic endotheli... BeFree 26359513 Detail
<0.001 Viral respiratory infection NA BeFree Detail
<0.001 Punctate inner choroidopathy NA BeFree Detail
<0.001 Middle Cerebral Artery Occlusion NA BeFree Detail
0.003 hyperuricemia NA BeFree,GAD Detail
0.001 Granulomatous disorder NA BeFree Detail
0.003 Malignant neoplasm of kidney NA BeFree,GAD Detail
<0.001 Abdominal symptom NA BeFree Detail
0.001 End Stage Liver Disease Genetic variation in TNFA predicts protection from severe bacterial infections i... BeFree 24361409 Detail
<0.001 Chronic lung disease NA BeFree Detail
<0.001 Otitis media recurrent NA BeFree Detail
<0.001 early pregnancy NA BeFree Detail
<0.001 Frontotemporal Lobar Degeneration NA BeFree Detail
<0.001 Idiopathic Inflammatory Myopathies NA BeFree Detail
<0.001 Well Differentiated Oligodendroglioma NA BeFree Detail
0.002 Hereditary Autoinflammatory Diseases NA BeFree Detail
<0.001 Mitochondrial Diseases NA BeFree Detail
<0.001 malignant peripheral nerve sheath tumor NA BeFree Detail
0.003 brain infarction NA BeFree,GAD Detail
<0.001 Acute Cerebrovascular Accidents NA BeFree Detail
<0.001 Multiple Sclerosis, Primary Progressive NA BeFree Detail
<0.001 Multiple Sclerosis, Secondary Progressive NA BeFree Detail
0.002 Multiple Sclerosis, Relapsing-Remitting NA BeFree Detail
<0.001 Bardet-Biedl syndrome NA BeFree Detail
0.002 Somatosensory Disorders NA GAD Detail
0.007 Hypoxia-Ischemia, Brain NA GAD,LHGDN Detail
<0.001 Marden-Walker syndrome NA BeFree Detail
<0.001 Aicardi-Goutieres syndrome 1 NA BeFree Detail
<0.001 malignant pleural mesothelioma NA BeFree Detail
<0.001 liver scarring NA BeFree Detail
<0.001 nasal allergy NA BeFree Detail
<0.001 Subfertility, Male NA BeFree Detail
<0.001 Dry cough NA BeFree Detail
<0.001 premalignant lesion NA BeFree Detail
0.010 Helicobacter pylori infection NA BeFree,GAD Detail
<0.001 Anaphylaxis (non medication) NA BeFree Detail
0.002 Sleep Disorders NA GAD Detail
<0.001 Adenoviral infections NA BeFree Detail
0.002 Pregnancy associated hypertension NA GAD Detail
<0.001 bipolar I disorder NA BeFree Detail
<0.001 Oestrogen deficiency NA BeFree Detail
<0.001 Invasive breast carcinoma NA BeFree Detail
0.120 Diabetic Cardiomyopathies NA CTD_human Detail
<0.001 Rhabdoid Tumor of the Kidney NA BeFree Detail
<0.001 Rhabdomyosarcoma recurrent NA BeFree Detail
0.002 Endothelial dysfunction Neutralization of tumor necrosis factor-α and IL-6 (both downstream of IL-17A) r... BeFree 25341795 Detail
0.002 Endothelial dysfunction Tetrahydroxystilbene glucoside improves TNF-α-induced endothelial dysfunction: i... BeFree 25571766 Detail
0.002 High altitude illness NA GAD Detail
0.004 Acute GVH disease NA BeFree Detail
0.001 breast adenocarcinoma NA BeFree Detail
<0.001 Plasmodium vivax infection NA BeFree Detail
<0.001 Distal colitis NA BeFree Detail
0.202 Drug-Induced Liver Injury NA CTD_human,GAD,RGD Detail
<0.001 ABO incompatibility NA BeFree Detail
<0.001 Malignant melanoma, metastatic NA BeFree Detail
<0.001 Mycosis fungoides/Sezary syndrome NOS Here we report recurrent point mutations and genomic gains of TNFRSF1B, encoding... BeFree 26258847 Detail
<0.001 Segmental Ileitis NA BeFree Detail
0.004 Chronic graft-versus-host disease NA BeFree,GAD Detail
<0.001 Pancolitis NA BeFree Detail
0.002 latent infection NA BeFree Detail
<0.001 Infectious disease of lung NA BeFree Detail
<0.001 Advanced cancer NA BeFree Detail
0.128 Cardiomyopathies NA BeFree,CTD_human,GAD Detail
<0.001 conjunctivochalasis NA BeFree Detail
<0.001 Cerebral Ischemia NA BeFree Detail
<0.001 Cerebral Aneurysm NA BeFree Detail
0.007 ovarian neoplasm NA BeFree,LHGDN Detail
0.003 autoimmune thyroiditis NA BeFree,GAD Detail
<0.001 Metastatic Prostate Carcinoma TRAP1/Hsp75 (tumor necrosis factor receptor-associated protein 1), a paralogue o... BeFree 25189320 Detail
<0.001 precancerous lesions NA BeFree Detail
<0.001 cholecystolithiasis NA BeFree Detail
0.001 Vascular inflammations NA BeFree Detail
0.006 Ischemic stroke Our results highlight that genes IL-8 and TNF have close relationship with acute... BeFree,GAD 24817293 Detail
0.006 Ischemic stroke TNFα gene G-308A polymorphism and the risk of ischemic stroke. BeFree,GAD 25482248 Detail
0.132 Acute coronary syndrome NA BeFree,CTD_human,GAD,LHGDN Detail
<0.001 Primary infection NOS NA BeFree Detail
0.127 coronary restenosis NA CTD_human,GAD,LHGDN Detail
<0.001 Polyp of large intestine NA BeFree Detail
<0.001 Nosocomial pneumonia NA BeFree Detail
0.007 Spondylarthritis Levels of Dkk-1 were similar in SpA SF and RA SF and were not correlated with TN... BeFree,GAD 25941031 Detail
0.006 Spondylarthropathies NA BeFree,GAD Detail
0.017 Papillomavirus Infections NA GAD,LHGDN Detail
0.005 Arthritis, Collagen-Induced Loss of SH3 domain-binding protein 2 function suppresses bone destruction in tum... BeFree 25470448 Detail
0.201 Arthritis, Experimental NA BeFree,CTD_human,RGD Detail
<0.001 Heart Failure, Diastolic NA BeFree Detail
0.005 HIV-Associated Lipodystrophy Syndrome NA GAD,LHGDN Detail
0.012 Malignant neoplasm of ovary In vitro and in vivo studies have highlighted different molecular mechanisms tha... BeFree,GAD 25030086 Detail
<0.001 Primary HIV infection NA BeFree Detail
<0.001 respiratory failure NA BeFree Detail
<0.001 endometrial adenocarcinoma NA BeFree Detail
<0.001 Corneal melt NA BeFree Detail
0.004 Squamous cell carcinoma of the head and neck The main aim was to investigate the potential prognostic significance of tumor n... BeFree 24858806 Detail
0.010 severe acute respiratory syndrome Through our genomics-based approach, we found topological differences in the kin... BeFree,GAD 25534508 Detail
<0.001 splenic sequestration NA BeFree Detail
<0.001 Anemia, Diamond-Blackfan NA BeFree Detail
0.124 sarcoma Based on this knowledge, we conceived to use modified MSC to deliver tumor necro... BeFree,CTD_human 25420617 Detail
<0.001 Lymphocytic infiltration NA BeFree Detail
<0.001 Hepatitis, Drug-Induced NA BeFree Detail
<0.001 Advanced cirrhosis NA BeFree Detail
0.002 attention deficit hyperactivity disorder NA GAD Detail
<0.001 Persistent infection NA BeFree Detail
0.002 major depressive disorder NA BeFree Detail
<0.001 Mild cognitive disorder NA BeFree Detail
<0.001 Acral pseudolymphomatous angiokeratoma of children (APACHE) NA BeFree Detail
0.012 TNF receptor-associated periodic fever syndrome (TRAPS) Tumor necrosis factor receptor-associated periodic syndrome (TRAPS), formerly kn... BeFree 24935411 Detail
0.012 TNF receptor-associated periodic fever syndrome (TRAPS) Tumour necrosis factor receptor I blockade shows that TNF-dependent and TNF-inde... BeFree 26202849 Detail
<0.001 Avellino corneal dystrophy NA BeFree Detail
<0.001 Left ventricular systolic dysfunction NA BeFree Detail
<0.001 Chronic leukemia (category) NA BeFree Detail
<0.001 Anxiety neurosis (finding) Variations in three cytokine genes (i.e., interleukin (IL) 1 beta, IL1 receptor ... BeFree 25249351 Detail
<0.001 Lipoatrophy NA BeFree Detail
<0.001 Granulocytosis NA BeFree Detail
<0.001 Enthesitis NA BeFree Detail
0.004 Inflammatory disorder These results reveal a crucial role for TNFα/TNFR2 axis in the protection of the... BeFree 24802997 Detail
0.004 Inflammatory disorder Therefore, the TNF-α/IL-32 axis may be a potential therapeutic target for airway... BeFree 25157456 Detail
0.004 Inflammatory disorder These data provide evidence that using gene expression modules related to inflam... BeFree 25371395 Detail
0.004 Inflammatory disorder Tumor necrosis factor (TNF) blockage therapy is effective for the treatment of m... BeFree 25661729 Detail
0.002 Chronic inflammatory disorder TNFα overexpression has been associated with several chronic inflammatory diseas... BeFree 24802997 Detail
<0.001 Primary Effusion Lymphoma NA BeFree Detail
<0.001 Precursor B-cell lymphoblastic leukemia NA BeFree Detail
<0.001 Chronic myeloproliferative disorder Plasma concentrations of interleukin 6, interleukin 15, and tumor necrosis facto... BeFree 25912019 Detail
<0.001 Low Grade Squamous Intraepithelial Neoplasia NA BeFree Detail
<0.001 Localized vitiligo NA BeFree Detail
<0.001 Generalized vitiligo NA BeFree Detail
<0.001 Eosinophilic disorder NA BeFree Detail
0.002 Liver regeneration disorder Elevated PPM1A levels led to attenuation of hPXR inhibition by tumor necrosis fa... BeFree 25561723 Detail
0.002 Liver regeneration disorder In the in vitro experiments, LPS preconditioning of ASCs enhanced the mRNA expre... BeFree 25890074 Detail
0.002 Liver regeneration disorder Tumor necrosis factor-inducible gene 6 promotes liver regeneration in mice with ... BeFree 25890163 Detail
<0.001 M5b Acute differentiated monocytic leukemia NA BeFree Detail
<0.001 Adenocarcinoma of large intestine NA BeFree Detail
0.003 mucocutaneous leishmaniasis NA BeFree,GAD Detail
<0.001 Hormone refractory prostate cancer NA BeFree Detail
<0.001 AIDS-Related Non-Hodgkin Lymphoma NA BeFree Detail
<0.001 Anaplastic Large Cell Lymphoma, ALK-Positive NA BeFree Detail
<0.001 Classical Hodgkin's Lymphoma NA BeFree Detail
0.002 gastric cardia adenocarcinoma NA GAD Detail
<0.001 Gastric Mucosa-Associated Lymphoid Tissue Lymphoma NA BeFree Detail
<0.001 Infiltrating Cervical Carcinoma NA BeFree Detail
<0.001 Intestinal Graft Versus Host Disease In view of the crucial role of TNF and intestinal cell death in graft-versus-hos... BeFree 26012567 Detail
<0.001 Invasive Carcinoma NA BeFree Detail
<0.001 Mucinous Neoplasm Expression of IL-1, TNF-α and COX-2 increased with the stage of the disease in b... BeFree 25007180 Detail
0.002 pancreatic ductal adenocarcinoma Finally, upstream signaling pathways were analyzed, with TNF-α and EGF being the... BeFree 24567526 Detail
0.002 pancreatic ductal adenocarcinoma These results not only suggest that GSK-3β overexpression and nuclear localizati... BeFree 24675460 Detail
0.002 pancreatic ductal adenocarcinoma In the present study, by analysis of genome-wide patterns of c-Rel-dependent gen... BeFree 25299780 Detail
0.002 pancreatic ductal adenocarcinoma Here we show in human PDAC that a high percentage of infiltrating pY323(+) T cel... BeFree 26479921 Detail
<0.001 Recurrent Head and Neck Carcinoma NA BeFree Detail
<0.001 Sporadic Breast Carcinoma Association of TNF-α, TNFRSF1A and TNFRSF1B gene polymorphisms with the risk of ... BeFree 25010932 Detail
<0.001 Carcinoma of urinary bladder, superficial NA BeFree Detail
<0.001 Testicular Germ Cell Tumor NA BeFree Detail
<0.001 Epithelioma NA BeFree Detail
<0.001 Pleural Mesothelioma NA BeFree Detail
<0.001 Undifferentiated leukemia Transmembrane TNF-α preferentially expressed by leukemia stem cells and blasts i... BeFree 26224647 Detail
0.002 renal carcinoma NA BeFree Detail
0.002 hearing impairment NA GAD Detail
<0.001 Cardiac fibrosis NA BeFree Detail
<0.001 Vascular lesions NA BeFree Detail
<0.001 Chronic Q Fever NA BeFree Detail
0.002 Cardiomyopathy, Familial Idiopathic The tumor necrosis factor-α -238G/A and IL-6 -572G/C gene polymorphisms and the ... BeFree 25274950 Detail
0.002 Cardiomyopathy, Familial Idiopathic Polymorphisms of tumor necrosis factor-alpha and interleukin-6 gene and C-reacti... BeFree 25827698 Detail
0.002 Methamphetamine abuse NA GAD Detail
<0.001 Diabetic foot ulcer Genetic association of IL-6, TNF-α and SDF-1 polymorphisms with serum cytokine l... BeFree 25839939 Detail
0.142 Mammary Neoplasms Exposure of MSCs to TNF-α led to potent CCL2-induced migration of monocytic cell... BeFree,CTD_human,GAD,LHGDN 25928089 Detail
0.142 Mammary Neoplasms ONO-8430506 also decreased plasma TNF-α and G-CSF cytokine levels by >70% and le... BeFree,CTD_human,GAD,LHGDN 26071407 Detail
<0.001 Hippocampal sclerosis NA BeFree Detail
0.003 Human T-cell lymphotropic virus 1 infection NA BeFree,GAD Detail
<0.001 Neuropathogenesis NA BeFree Detail
<0.001 Salivary Gland Pleomorphic Adenoma NA BeFree Detail
<0.001 Skin Carcinogenesis NA BeFree Detail
<0.001 Tumor-Associated Vasculature NA BeFree Detail
0.001 Tumor Angiogenesis Previous studies demonstrated that the vascular endothelial growth inhibitor (VE... BeFree 25182731 Detail
<0.001 Tumor Immunity NA BeFree Detail
0.001 Tumor Promotion NA BeFree Detail
<0.001 Xenograft Model NA BeFree Detail
0.037 colorectal cancer Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to ... BeFree,GAD 25174402 Detail
0.037 colorectal cancer Consistently, we found that, in human colorectal cancer tissues, high levels of ... BeFree,GAD 25306394 Detail
0.037 colorectal cancer Previously, we demonstrated that tumor necrosis factor (TNF) induced DAPK-mediat... BeFree,GAD 25380824 Detail
0.037 colorectal cancer Increased expression of tumor necrosis factor-α is associated with advanced colo... BeFree,GAD 25561807 Detail
0.120 brain edema NA BeFree,CTD_human Detail
0.007 Sjogren's syndrome NA BeFree,GAD Detail
<0.001 Rectal Tumors NA BeFree Detail
<0.001 Multifocal choroiditis NA BeFree Detail
<0.001 Methamphetamine dependence NA BeFree Detail
0.003 Pneumocystis jiroveci pneumonia NA BeFree,GAD Detail
<0.001 infective endocarditis In this study, 14 single nucleotide variants (SNVs) in genes coding for interleu... BeFree 25299518 Detail
<0.001 Rash and Dermatitis Adverse Event Associated with Chemoradiation NA BeFree Detail
0.002 Non-Malignant Ascites Adverse Event NA BeFree Detail
0.002 Chronic Kidney Diseases NA BeFree Detail
<0.001 Leprosy, Paucibacillary NA BeFree Detail
0.006 Renal Insufficiency NA BeFree,GAD,LHGDN Detail
<0.001 Preterm Premature Rupture of Fetal Membranes NA BeFree Detail
0.005 Delayed Graft Function NA GAD Detail
<0.001 Oral Mucositis NA BeFree Detail
<0.001 Latent Tuberculosis NA BeFree Detail
<0.001 Immune Reconstitution Inflammatory Syndrome NA BeFree Detail
0.002 Glioblastoma multiforme NA BeFree Detail
0.009 Cirrhosis Genetic heterogeneity in the TNFα and IL1β gene promoters influences the risk of... BeFree,GAD 24751829 Detail
0.009 Cirrhosis Our study suggests that CB2R agonists have the potential to treat BT and various... BeFree,GAD 24953022 Detail
0.009 Cirrhosis To assess the contribution of tumor necrosis factor (TNF)β +252 polymorphisms to... BeFree,GAD 25556449 Detail
<0.001 Macular dystrophy, corneal type 1 NA BeFree Detail
<0.001 Disorder characterized by eosinophilia NA BeFree Detail
<0.001 androgen independent prostate cancer Accordingly, it decreased expression of ER-α target PS2 (P<0.01) and increased e... BeFree 25655200 Detail
0.002 tumor vasculature NA BeFree Detail
<0.001 Inflammatory polyarthritis Valine at position 11 also was associated with higher all-cause mortality in pat... BeFree 25919528 Detail
<0.001 Arthritis, Bacterial NA BeFree Detail
<0.001 Pneumonia, Ventilator-Associated NA BeFree Detail
<0.001 Peripheral Arterial Diseases Association of monocyte tumor necrosis factor α expression and serum inflammator... BeFree 25095746 Detail
<0.001 Anhydrotic Ectodermal Dysplasias NA BeFree Detail
<0.001 HIV Lipodystrophy Our study validates the association of the TNF-α 238G/A SNP allelic variant with... BeFree 25439236 Detail
<0.001 Lung Melanoma NA BeFree Detail
<0.001 Non-Neoplastic Disorder NA BeFree Detail
<0.001 PERIODONTITIS, LOCALIZED AGGRESSIVE NA BeFree Detail
0.001 Aggressive periodontitis, generalized Genetic polymorphisms of TNFA and IL-1A and generalized aggressive periodontitis... BeFree 26193214 Detail
0.004 Severe Sepsis NA BeFree Detail
0.085 Idiopathic Pulmonary Fibrosis NA BeFree,GAD,MGD Detail
<0.001 IgE-mediated allergic asthma NA BeFree Detail
0.120 PSORIATIC ARTHRITIS, SUSCEPTIBILITY TO (finding) NA CLINVAR Detail
0.001 IMMUNE SUPPRESSION This suggests that the protective effect of Fn14 blockade in allo-HCT is based o... BeFree 26012567 Detail
<0.001 MULTICYSTIC RENAL DYSPLASIA, BILATERAL NA BeFree Detail
<0.001 Lymphoproliferative Syndrome, X-Linked, 2 NA BeFree Detail
<0.001 HYPER-IgM IMMUNODEFICIENCY, X-LINKED, WITH ECTODERMAL DYSPLASIA, HYPOHIDROTIC NA BeFree Detail
0.080 PULMONARY DISEASE, CHRONIC OBSTRUCTIVE, SEVERE EARLY-ONSET NA MGD Detail
0.002 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) The combination of tumour necrosis factor-α -308A and interleukin-10 -1082G gene... BeFree 25283497 Detail
0.080 Neuropathy, Painful NA BeFree,RGD Detail
<0.001 Myeloproliferative disorder, chronic, with eosinophilia NA BeFree Detail
<0.001 LATE-ONSET RETINAL DEGENERATION (disorder) In this study, we investigated the influence of the rd8 mutation on the retinal ... BeFree 25814825 Detail
0.120 PLASMODIUM FALCIPARUM BLOOD INFECTION LEVEL NA CTD_human Detail
0.120 MALARIA, CEREBRAL, SUSCEPTIBILITY TO (finding) NA CLINVAR Detail
<0.001 Friedreich ataxia 1 NA BeFree Detail
<0.001 Pyogenic Arthritis, Pyoderma Gangrenosum and Acne NA BeFree Detail
0.122 Venous thromboembolism NA CTD_human,GAD Detail
0.120 AMYOTROPHIC LATERAL SCLEROSIS 1 NA CTD_human Detail
<0.001 Amyotrophic Lateral Sclerosis, Sporadic NA BeFree Detail
<0.001 Majeed syndrome NA BeFree Detail
<0.001 PHOTOPAROXYSMAL RESPONSE 1 NA BeFree Detail
0.080 Multiple sclerosis, susceptibility to NA MGD Detail
0.120 ASTHMA, SUSCEPTIBILITY TO (finding) NA CLINVAR Detail
0.048 coronary artery disease Diagnostic potential of differentially expressed Homer1, IL-1β, and TNF-α in cor... BeFree,GAD,LHGDN 25551602 Detail
<0.001 Severe persistent asthma NA BeFree Detail
<0.001 Philadelphia chromosome-positive acute lymphoblastic leukemia NA BeFree Detail
0.003 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma NA BeFree,LHGDN Detail
0.008 Precursor Cell Lymphoblastic Leukemia Lymphoma Donors with HLA-B*58:01/TNFα − 308A haplotype are unfavorable to haploidentical ... BeFree,GAD 25545232 Detail
<0.001 Gaucher Disease, Type 1 NA BeFree Detail
0.002 Proteinuria Adverse Event NA GAD Detail
<0.001 Regurgitation NA BeFree Detail
<0.001 Leukemia, B-Cell A proliferation-inducing ligand (APRIL) is a tumor-necrosis factor (TNF) family ... BeFree 25612651 Detail
<0.001 Depressive Disorder, Treatment-Resistant NA BeFree Detail
<0.001 Urothelial Carcinoma NA BeFree Detail
0.002 exudative macular degeneration NA GAD Detail
0.058 liver carcinoma Genetic heterogeneity in the TNFα and IL1β gene promoters influences the risk of... BeFree,GAD,LHGDN 24751829 Detail
0.058 liver carcinoma Rocaglamide overcomes tumor necrosis factor-related apoptosis-inducing ligand re... BeFree,GAD,LHGDN 25333816 Detail
0.058 liver carcinoma Taken together, these findings demonstrate that TIPE2 was able to suppress TNF-α... BeFree,GAD,LHGDN 25339267 Detail
0.058 liver carcinoma Tumor necrosis factor-alpha gene -308G > A polymorphism alters the risk of hepat... BeFree,GAD,LHGDN 25420786 Detail
0.058 liver carcinoma Heat shock protein 20 (HSPB6) regulates TNF-α-induced intracellular signaling pa... BeFree,GAD,LHGDN 25447820 Detail
0.058 liver carcinoma To assess the contribution of tumor necrosis factor (TNF)β +252 polymorphisms to... BeFree,GAD,LHGDN 25556449 Detail
0.058 liver carcinoma Haplotype analysis revealed that TNF-α (-308A; -238A) was significantly associat... BeFree,GAD,LHGDN 25982858 Detail
0.058 liver carcinoma Tumor Necrosis Factor-α Genotypes Are Associated with Hepatocellular Carcinoma R... BeFree,GAD,LHGDN 26408704 Detail
<0.001 Chronic secretory otitis media NA BeFree Detail
0.003 Chronic idiopathic neutropenia NA BeFree,GAD Detail
<0.001 Reproductive tract infection NA BeFree Detail
0.002 Cryopyrin-Associated Periodic Syndromes NA BeFree Detail
0.002 Chronic kidney disease stage 5 Association of tumour necrosis factor-α polymorphism in patients with end stage ... BeFree 25589331 Detail
0.001 Destructive Arthritis NA BeFree Detail
<0.001 Beryllium Disease NA BeFree Detail
0.005 Allergic rhinitis (disorder) NA BeFree,GAD Detail
0.120 Acute kidney injury NA CTD_human Detail
<0.001 Hypoadiponectinemia NA BeFree Detail
<0.001 Hepatitis B and hepatitis C Impact of surveillance of hepatitis b and hepatitis c in patients with inflammat... BeFree 25052345 Detail
0.002 Steatohepatitis NA BeFree Detail
0.001 Alcoholic Steatohepatitis NA BeFree Detail
0.002 Promyelocytic leukemia NA BeFree Detail
<0.001 Kashin-Beck Disease NA BeFree Detail
0.002 Infectious Otitis Media NA BeFree Detail
0.005 Weight Loss Adverse Event NA GAD Detail
0.002 Weight Gain Adverse Event NA GAD Detail
0.007 Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified NA GAD Detail
0.024 Chronic ulcerative colitis NA GAD Detail
0.002 Recurrent pregnancy loss NA GAD Detail
<0.001 Immunoglobulin a deficiency 1 NA BeFree Detail
<0.001 Bone Marrow failure syndromes TNF-α -308 G>A polymorphism and risk of bone marrow failure syndrome: A meta-ana... BeFree 25895473 Detail
<0.001 Gestational trophoblastic disease NA BeFree Detail
0.002 Juvenile dermatomyositis NA BeFree Detail
0.003 Nasopharyngeal carcinoma NA BeFree Detail
<0.001 Negative rheumatoid factor polyarthritis NA BeFree Detail
0.001 Plaque, Amyloid NA BeFree Detail
0.002 Cerebral Hemorrhage NA GAD Detail
<0.001 Recurrent aphthous ulcer NA BeFree Detail
<0.001 Right ventricular failure NA BeFree Detail
<0.001 Deficiency of glucose-6-phosphate dehydrogenase NA BeFree Detail
<0.001 Pulmonary arterial hypertension NA BeFree Detail
<0.001 Coxiella burnetii Infection NA BeFree Detail
<0.001 Pregnancy Related Skin Change NA BeFree Detail
<0.001 polycystic kidney disease 1 NA BeFree Detail
<0.001 Primary immunoglobulin A nephropathy (disorder) NA BeFree Detail
<0.001 Clinical sepsis NA BeFree Detail
<0.001 Idiopathic pulmonary arterial hypertension NA BeFree Detail
0.002 Nonalcoholic Steatohepatitis NA BeFree Detail
0.003 Ischemic Cerebrovascular Accident Our results highlight that genes IL-8 and TNF have close relationship with acute... BeFree 24817293 Detail
0.003 Ischemic Cerebrovascular Accident TNFα gene G-308A polymorphism and the risk of ischemic stroke. BeFree 25482248 Detail
<0.001 Small fiber neuropathy NA BeFree Detail
0.013 myelodysplastic syndrome NA BeFree,GAD,LHGDN Detail
0.003 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) NA BeFree Detail
<0.001 Homocysteinemia NA BeFree Detail
<0.001 American cutaneous leishmaniasis NA BeFree Detail
0.045 Juvenile arthritis NA BeFree,GAD,LHGDN Detail
<0.001 Reflux nephropathy (disorder) NA BeFree Detail
0.002 granulomatosis with polyangiitis NA GAD Detail
<0.001 AA amyloidosis NA BeFree Detail
<0.001 Progressive cGVHD NA BeFree Detail
<0.001 Triple Negative Breast Neoplasms To this end, we identified TNBC-driven molecular pathways such as the Janus kina... BeFree 25611337 Detail
0.002 Allergic disposition NA BeFree Detail
<0.001 aortic valve disease 2 NA BeFree Detail
<0.001 Allergic sensitization NA BeFree Detail
<0.001 Intracranial glioma NA BeFree Detail
<0.001 Neutrophilia (disorder) NA BeFree Detail
<0.001 Mammary adenocarcinoma NA BeFree Detail
0.186 Infection NA CTD_human,GAD,LHGDN Detail
<0.001 Staphylococcal toxic shock syndrome NA BeFree Detail
<0.001 Insulin resistance syndrome NA BeFree Detail
0.002 Thymus Neoplasms NA GAD Detail
0.005 juvenile rheumatoid arthritis NA BeFree Detail
<0.001 Juvenile psoriatic arthritis NA BeFree Detail
<0.001 Pulmonary hypertension, primary, 1, with hereditary hemorrhagic telangiectasia NA BeFree Detail
0.002 Experimental Organism Basal Cell Carcinoma NA BeFree Detail
<0.001 Diabetes in old age NA BeFree Detail
<0.001 Tumors in animals NA BeFree Detail
<0.001 Celiac disease in children TNFA Haplotype Genetic Testing Improves HLA in Estimating the Risk of Celiac Dis... BeFree 25915602 Detail
<0.001 Radiation Damage NA BeFree Detail
0.002 Hearing Loss NA GAD Detail
0.002 major depressive disorder At the gene level, TNF (rs76917; OR T=1.35, 95% CI 1.13-1.63; P=0.0034) was iden... BeFree 20351714 Detail
0.002 Unipolar Depression At the gene level, TNF (rs76917; OR T=1.35, 95% CI 1.13-1.63; P=0.0034) was iden... BeFree 20351714 Detail
0.121 Anorexia Only tumor necrosis factor alpha rs800629 was associated with anorexia (odds rat... BeFree 20012999 Detail
0.005 Spontaneous abortion NA GAD Detail
0.009 Abortion, Habitual NA GAD Detail
0.003 Acidosis, Lactic NA BeFree,LHGDN Detail
0.004 Acne Vulgaris NA BeFree,GAD Detail
0.005 acquired immunodeficiency syndrome NA BeFree,GAD Detail
<0.001 Acute alcoholic liver disease NA BeFree Detail
0.004 acute pancreatitis NA BeFree Detail
0.003 Acute-Phase Reaction NA LHGDN Detail
0.144 adenocarcinoma NA BeFree,CTD_human,GAD,LHGDN Detail
0.003 agammaglobulinemia NA LHGDN Detail
<0.001 agranulocytosis NA BeFree Detail
0.009 AIDS Dementia Complex NA BeFree,GAD Detail
<0.001 AIDS related complex NA BeFree Detail
0.205 Albuminuria NA CTD_human,GAD,RGD Detail
0.007 Alcoholic Intoxication, Chronic NA BeFree,GAD Detail
<0.001 alopecia areata NA BeFree Detail
0.008 Alveolar Bone Loss NA BeFree,GAD Detail
0.006 extrinsic allergic alveolitis NA BeFree,GAD,LHGDN Detail
0.199 Alzheimer's disease The cytokine tumor necrosis factor-alpha (TNF-α) is elevated in the blood of Alz... BeFree,CTD_human,GAD,LHGDN 24556805 Detail
0.199 Alzheimer's disease More importantly, changes in Aβ oligomer and sTNFR levels accurately differentia... BeFree,CTD_human,GAD,LHGDN 24635842 Detail
0.199 Alzheimer's disease Tumor necrosis factor receptor II (TNFRII) is one of the TNF receptor superfamil... BeFree,CTD_human,GAD,LHGDN 24824215 Detail
0.199 Alzheimer's disease Although the potential adverse effects of TNF-based AD therapies have been of co... BeFree,CTD_human,GAD,LHGDN 24998784 Detail
0.199 Alzheimer's disease TNF-α -308G/A and IL-8 -251T/A were significantly associated with AD and IL-1β +... BeFree,CTD_human,GAD,LHGDN 25315113 Detail
0.199 Alzheimer's disease The result of this meta-analysis suggests that TNF-alpha G308A polymorphism may ... BeFree,CTD_human,GAD,LHGDN 25735998 Detail
0.006 amyloidosis NA BeFree,GAD Detail
0.009 amyotrophic lateral sclerosis NA BeFree,GAD,LHGDN Detail
0.003 Bovine Anaplasmosis NA LHGDN Detail
0.133 anemia NA BeFree,CTD_human,LHGDN Detail
0.002 Anemia of chronic disease NA BeFree Detail
0.014 aplastic anemia NA BeFree,GAD,LHGDN Detail
0.123 Refractory anemias NA BeFree,CTD_human,GAD Detail
0.131 Anemia, Sickle Cell NA BeFree,CTD_human,GAD,LHGDN Detail
0.004 Aneurysm NA BeFree,LHGDN Detail
0.002 Aneurysm, Dissecting NA GAD Detail
0.005 Angina Pectoris NA GAD Detail
0.016 Angina, Unstable NA BeFree,GAD,LHGDN Detail
0.002 Fabry disease NA GAD Detail
0.121 Anorexia NA BeFree,CTD_human Detail
0.009 anorexia nervosa NA BeFree,GAD,LHGDN Detail
0.003 Anoxia NA LHGDN Detail
0.127 anthracosis NA BeFree,CTD_human,GAD Detail
0.120 Anxiety Disorders Variations in three cytokine genes (i.e., interleukin (IL) 1 beta, IL1 receptor ... BeFree,CTD_human 25249351 Detail
0.002 Aortic Diseases NA GAD Detail
0.002 Aortic Rupture NA GAD Detail
<0.001 aortic valve stenosis NA BeFree Detail
0.016 arteriosclerosis Moreover, miR-144-3p mimics (agomir) enhanced the expression of inflammatory fac... BeFree 24733347 Detail
0.016 arteriosclerosis Thus, TNFα induced miR-155 may serve as a negative feedback regulator in endothe... BeFree 24905663 Detail
0.016 arteriosclerosis Activation of CD137 (tumor necrosis factor receptor super family 9) promotes inf... BeFree 25032953 Detail
0.016 arteriosclerosis Osteoprotegerin (OPG) is a secretory glycoprotein that belongs to the tumor necr... BeFree 25323324 Detail
0.016 arteriosclerosis Furthermore, sortilin also seems to be involved in the development of atheroscle... BeFree 25702058 Detail
0.016 arteriosclerosis The atherosclerosis risk factor TNF was used as a positive control in this study... BeFree 26283334 Detail
<0.001 Arteriovenous fistula Our results propose that TNF-α -308 G > A genotype may be a potential genetic ma... BeFree 24126814 Detail
0.009 Congenital arteriovenous malformation NA BeFree,GAD,LHGDN Detail
0.056 arthritis Our results provide the evidence that the administration of 5-LOX inhibitors is ... BeFree,GAD,LHGDN 25229347 Detail
0.056 arthritis FAK inhibitors reduce synovial fibroblast invasion and migration, but synovial f... BeFree,GAD,LHGDN 25280866 Detail
0.056 arthritis The tumour necrosis factor (TNF)-α-induced proteins (TNFAIP)9 and TNFAIP3 play a... BeFree,GAD,LHGDN 25683200 Detail
0.056 arthritis Antagonists of tumor necrosis factor-α (TNFα) and IL-1β were equally effective i... BeFree,GAD,LHGDN 25867281 Detail
0.056 arthritis TNF-transgenic mice develop inflammatory-erosive arthritis associated with disru... BeFree,GAD,LHGDN 25959608 Detail
0.120 Arthritis, Infectious NA BeFree,CTD_human Detail
0.156 Arthritis, Psoriatic Biologic anti-tumour necrosis factor agents, such as etanercept, infliximab and ... BeFree,CTD_human,GAD,LHGDN 24566842 Detail
0.156 Arthritis, Psoriatic We determined the expression of ILT4 and analysed the relationship with the expr... BeFree,CTD_human,GAD,LHGDN 24676037 Detail
0.156 Arthritis, Psoriatic We aimed to characterize the PsA genotype by gene expression profile and to rese... BeFree,CTD_human,GAD,LHGDN 25339124 Detail
0.156 Arthritis, Psoriatic Our results support clinical trial data showing that PsA skin and joint disease ... BeFree,CTD_human,GAD,LHGDN 25512250 Detail
0.156 Arthritis, Psoriatic TNF-blocking agents, non-biological disease-modifying anti-rheumatic drugs (nbDM... BeFree,CTD_human,GAD,LHGDN 25980667 Detail
<0.001 Acute suppurative arthritis due to bacteria NA BeFree Detail
<0.001 arthus reaction NA BeFree Detail
0.003 aspergillosis NA BeFree,GAD Detail
0.002 asphyxia neonatorum NA GAD Detail
0.266 asthma Recently, the tumor necrosis factor superfamily member (TNFSF) 14/LIGHT has been... BeFree,CTD_human,GAD,LHGDN 25501580 Detail
0.266 asthma Therefore, the aim of the study was to assess the amount and activity of MMP-9 i... BeFree,CTD_human,GAD,LHGDN 25650123 Detail
0.266 asthma Effects of TNF-α polymorphisms on asthma risk: a systematic review and meta-anal... BeFree,CTD_human,GAD,LHGDN 25668892 Detail
0.266 asthma Polymorphisms of tumor necrosis factor-α, transforming growth factor-β, and inte... BeFree,CTD_human,GAD,LHGDN 25759826 Detail
0.266 asthma Healthy and asthmatic ASM cells were treated with TNF-α/IFN-γ for 24 hours in th... BeFree,CTD_human,GAD,LHGDN 25897650 Detail
0.266 asthma Gene polymorphisms of tumor necrosis factor alpha and antioxidant enzymes in bro... BeFree,CTD_human,GAD,LHGDN 25931357 Detail
0.004 Astrocytoma NA BeFree Detail
<0.001 Ataxia NA BeFree Detail
0.173 atherosclerosis Moreover, miR-144-3p mimics (agomir) enhanced the expression of inflammatory fac... BeFree,CTD_human,GAD,LHGDN 24733347 Detail
0.173 atherosclerosis Thus, TNFα induced miR-155 may serve as a negative feedback regulator in endothe... BeFree,CTD_human,GAD,LHGDN 24905663 Detail
0.173 atherosclerosis Activation of CD137 (tumor necrosis factor receptor super family 9) promotes inf... BeFree,CTD_human,GAD,LHGDN 25032953 Detail
0.173 atherosclerosis Osteoprotegerin (OPG) is a secretory glycoprotein that belongs to the tumor necr... BeFree,CTD_human,GAD,LHGDN 25323324 Detail
0.173 atherosclerosis Furthermore, sortilin also seems to be involved in the development of atheroscle... BeFree,CTD_human,GAD,LHGDN 25702058 Detail
0.173 atherosclerosis The atherosclerosis risk factor TNF was used as a positive control in this study... BeFree,CTD_human,GAD,LHGDN 26283334 Detail
0.002 atrial fibrillation NA GAD Detail
0.003 autistic disorder NA BeFree,GAD Detail
<0.001 Melanoma, B16 Cytokines, that is, interleukin-1β and tumor necrosis factor-α from MDSCs are re... BeFree 24882582 Detail
0.005 Bacteremia NA BeFree,GAD Detail
0.005 Bacterial Infections Genetic variation in TNFA predicts protection from severe bacterial infections i... BeFree,GAD 24361409 Detail
0.001 Balkan nephropathy NA BeFree Detail
0.040 Behcet Syndrome NA BeFree,GAD,LHGDN Detail
0.132 berylliosis NA CTD_human,GAD,LHGDN Detail
0.002 beta thalassemia NA GAD Detail
<0.001 biliary atresia Tumour necrosis factor-alpha gene polymorphisms in Iranian patients with biliary... BeFree 25047315 Detail
0.002 Biliary Tract Neoplasm NA GAD Detail
0.009 bipolar disorder In the present paper we tested the enrichment of molecular pathways related to i... BeFree,GAD,LHGDN 25855618 Detail
0.007 bird fancier's lung NA GAD Detail
0.023 Malignant neoplasm of urinary bladder In this study, we investigated the effects and molecular mechanisms of metformin... BeFree,GAD 24714080 Detail
0.126 Bladder Neoplasm NA BeFree,CTD_human,GAD,LHGDN Detail
<0.001 Blast Phase NA BeFree Detail
0.002 blastomycosis NA GAD Detail
0.002 Bone Diseases iNKT cells from subjects with bone and cardiovascular impairment expressed high ... BeFree 25329381 Detail
0.002 Bone Diseases LIGHT, a TNF superfamily member, is involved in T-cell homeostasis and erosive b... BeFree 25460501 Detail
<0.001 Bone Marrow Diseases NA BeFree Detail
<0.001 borderline personality disorder NA BeFree Detail
0.005 boutonneuse fever NA BeFree,GAD,LHGDN Detail
<0.001 Brain Diseases NA BeFree Detail
0.002 Brain Neoplasms NA BeFree Detail
0.070 Malignant neoplasm of breast Tumor necrosis factor receptor-associated factor 4 (TRAF4) is upregulated in var... BeFree,GAD 24990246 Detail
0.070 Malignant neoplasm of breast To better understand the roles of single nucleotide polymorphisms (SNPs) in the ... BeFree,GAD 25010932 Detail
0.070 Malignant neoplasm of breast Association between the tumor necrosis factor alpha gene -308G> A polymorphism a... BeFree,GAD 25149156 Detail
0.070 Malignant neoplasm of breast Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can ind... BeFree,GAD 25150312 Detail
0.070 Malignant neoplasm of breast The overexpression of CMTM1_v17 in the breast cancer cell line MDA-MB-231 promot... BeFree,GAD 25175386 Detail
0.070 Malignant neoplasm of breast The important function of FASN in the drug tolerance of breast cancer may be due... BeFree,GAD 25292037 Detail
0.070 Malignant neoplasm of breast In the current study we examined the expression and function of HOTAIR in MCF-7-... BeFree,GAD 25328122 Detail
0.070 Malignant neoplasm of breast In conclusion, our findings support a contributing role of certain TNF-α and TLR... BeFree,GAD 25332681 Detail
0.070 Malignant neoplasm of breast Tumor necrosis factor-α sensitizes breast cancer cells to natural products with ... BeFree,GAD 25419573 Detail
0.070 Malignant neoplasm of breast TNFα was increased upon overexpression of miR562, which was reversed when ANXA1 ... BeFree,GAD 25536365 Detail
0.070 Malignant neoplasm of breast NFKB1, NFKBIA, IL-8, IL-10, and TNF polymorphisms could serve as useful predicti... BeFree,GAD 25559835 Detail
0.070 Malignant neoplasm of breast Melanoma A375 and breast carcinoma SKBR3 cells were the most sensitive, and thei... BeFree,GAD 25677845 Detail
0.070 Malignant neoplasm of breast In this study, we examined protein arginine methyltransferase 5 (PRMT5) and tumo... BeFree,GAD 25704480 Detail
0.070 Malignant neoplasm of breast By testing a panel of different cytokines, chemokines, growth factors and other ... BeFree,GAD 25900663 Detail
0.070 Malignant neoplasm of breast Regulation of the inflammatory profile of stromal cells in human breast cancer: ... BeFree,GAD 25928089 Detail
0.121 bronchiectasis NA BeFree,CTD_human Detail
0.003 bronchiolitis NA BeFree,GAD Detail
<0.001 bronchiolitis obliterans NA BeFree Detail
0.002 Bronchiolitis, Viral NA GAD Detail
0.002 bronchopneumonia NA GAD Detail
0.011 bronchopulmonary dysplasia NA BeFree,GAD Detail
0.010 brucellosis NA BeFree,GAD Detail
<0.001 Bunion NA BeFree Detail
0.003 Burkitt lymphoma NA BeFree,LHGDN Detail
0.003 burning mouth syndrome NA LHGDN Detail
0.002 byssinosis NA GAD Detail
0.130 Cachexia Regulation of hepatic cardiolipin metabolism by TNFα: Implication in cancer cach... BeFree,CTD_human,GAD 26327596 Detail
0.003 calcinosis NA BeFree,GAD Detail
0.003 candidiasis NA BeFree,GAD Detail
0.009 Malignant tumor of colon In search for novel strategies in colon cancer treatment, we investigated the un... BeFree 25285768 Detail
0.001 Malignant neoplasm of skin Tumour necrosis factor alpha (TNF-α) inhibitors are associated with an increased... BeFree 24206262 Detail
0.001 Malignant neoplasm of skin There may be a small risk of lymphoma and possibly skin cancer with anti-tumor n... BeFree 25251059 Detail
0.001 Malignant neoplasm of thyroid NA BeFree Detail
0.007 basal cell carcinoma NA GAD,LHGDN Detail
0.009 Non-small cell lung carcinoma Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising a... BeFree 25522273 Detail
0.009 Non-small cell lung carcinoma In conclusion, the combination chemotherapy of VNR + DIF may be a promising trea... BeFree 25573239 Detail
<0.001 Carcinoma, Papillary NA BeFree Detail
0.022 renal cell carcinoma NA BeFree,GAD,LHGDN Detail
Annotation

Annotations

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As this response was inhibited by a blocking anti-TNFα antibody, drug targeting HIV ssRNA-driven TLR... DisGeNET Detail
Experimental evidence support soluble receptors for tumor necrosis factor alpha as important mediato... DisGeNET Detail
No significant relation of the TNF-α -238G/A polymorphism with CVD was found; however, this single n... DisGeNET Detail
The tumor necrosis factor-alpha (TNF-a) and interleukin (IL)-6 gene polymorphism has a controversial... DisGeNET Detail
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TNFA promoter haplotypes associate with CD independently from HLA. DisGeNET Detail
The Chi-square test, multivariable logistic regression analysis with adjustment for covariates, as w... DisGeNET Detail
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TNF-related apoptosis inducing ligand (TRAIL), a member of the TNF superfamily released by microglia... DisGeNET Detail
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Re-expression of HPV16 E2 in SiHa (human cervical cancer) cells potentiates NF-κB activation induced... DisGeNET Detail
TNF-α -308 G/A as a risk marker of cervical cancer progression in the Polish population. DisGeNET Detail
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These findings suggest that the SH3BP2 cherubism mutation can cause jawbone destruction by promoting... DisGeNET Detail
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A genome-wide association study (GWAS) identified tumor necrosis factor superfamily member 15 (TNFSF... DisGeNET Detail
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This study suggested that persistent expression of extracellular HMGB-1 and DNA fragments in cholest... DisGeNET Detail
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In contrast, HERV env expressing choriocarcinoma cell lines suppressed T-cell proliferation and LPS-... DisGeNET Detail
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In mice, IL-19 up-regulates TNFα and IL-6 expression and its deficiency increases susceptibility to ... DisGeNET Detail
We found the BAG-1 isoform BAG-1M upregulated threefold in human Caco-2 cells following stimulation ... DisGeNET Detail
Monocytes/macrophages are major producers of tumor necrosis factor-α (TNF-α), a representative cytok... DisGeNET Detail
In an experimental model of colitis, mucosal VDR expression is reduced over time with the progressio... DisGeNET Detail
SEW2871 treatment attenuated established colitis associated with decreased CD4+ T cells in colon lam... DisGeNET Detail
Here we use wildtype (WT) and mice lacking Tnf (Tnf-/-) in an acute TNBS colitis model to investigat... DisGeNET Detail
Inhibition of the tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK)/fibroblast grow... DisGeNET Detail
Our data suggested that SGK1 may protect IECs in colitis from tumor necrosis factor-α-induced apopto... DisGeNET Detail
In addition, IL-10 KO mice receiving Bifico treatment had reduced mucosal secretion of tumor necrosi... DisGeNET Detail
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Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal c... DisGeNET Detail
Consistently, we found that, in human colorectal cancer tissues, high levels of TNF-α correlates wit... DisGeNET Detail
Previously, we demonstrated that tumor necrosis factor (TNF) induced DAPK-mediated apoptosis in colo... DisGeNET Detail
Increased expression of tumor necrosis factor-α is associated with advanced colorectal cancer stages... DisGeNET Detail
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Diagnostic potential of differentially expressed Homer1, IL-1β, and TNF-α in coronary artery disease... DisGeNET Detail
Diagnostic potential of differentially expressed Homer1, IL-1β, and TNF-α in coronary artery disease... DisGeNET Detail
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In a previous cross-sectional study from our centre the clinical effect (as described by FEV1, BMI z... DisGeNET Detail
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The allelic as well as genotypic frequencies of TNF-α and IL-10 did not significantly differ between... DisGeNET Detail
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High producing tumor necrosis factor alpha gene alleles in protection against severe manifestations ... DisGeNET Detail
However, while DENV-NS3 specific T cells of those with mild/sub clinical dengue infection were more ... DisGeNET Detail
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TNF-α -308G/A and IL-8 -251T/A were significantly associated with AD and IL-1β +3953C/T with late-li... DisGeNET Detail
TNF was not a moderator of the effects of either interpersonal or non-interpersonal stress on later ... DisGeNET Detail
Long-term potentiation and depression are reduced in colitic animals, and the synaptic alterations a... DisGeNET Detail
TNF-α -308G/A and IL-8 -251T/A were significantly associated with AD and IL-1β +3953C/T with late-li... DisGeNET Detail
TNF was not a moderator of the effects of either interpersonal or non-interpersonal stress on later ... DisGeNET Detail
Long-term potentiation and depression are reduced in colitic animals, and the synaptic alterations a... DisGeNET Detail
The present study suggests that there is a lack of association of potent proinflammatory cytokine TN... DisGeNET Detail
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Genetic endowment of proinflammatory cytokine tumor necrosis factor-α (-) 308 G > A polymorphism to ... DisGeNET Detail
Associations between TNF-α-308A/G polymorphism and susceptibility with dermatomyositis: a meta-analy... DisGeNET Detail
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The hypermethylation of TNFα in adipose tissue may contribute to reduce the inflammation associated ... DisGeNET Detail
TNF and receptor activator of NF-κB ligand (RANKL), two ligands associated with diabetes, induce NIK... DisGeNET Detail
The hypermethylation of TNFα in adipose tissue may contribute to reduce the inflammation associated ... DisGeNET Detail
TNF and receptor activator of NF-κB ligand (RANKL), two ligands associated with diabetes, induce NIK... DisGeNET Detail
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In conclusion, our meta-analysis results indicate that TNF -308 A/G and -857 T/C polymorphisms are i... DisGeNET Detail
Linkage disequilibrium with HLA-DRB1-DQB1 haplotypes explains the association of TNF-308G>A variant ... DisGeNET Detail
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The present study aims to examine the association of tumor necrosis factor-α (TNF-α) g.-308 G > A an... DisGeNET Detail
Genetic variants in angiotensin-converting enzyme (ACE), tumor necrosis factor-alpha (TNF-α) and ery... DisGeNET Detail
Association of tumor necrosis factor (TNF) promoter polymorphisms with plasma TNF-α levels and susce... DisGeNET Detail
Oxidative stress and its association with TNF-α-308 G/C and IL-1α-889 C/T gene polymorphisms in pati... DisGeNET Detail
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The present study aims to examine the association of tumor necrosis factor-α (TNF-α) g.-308 G > A an... DisGeNET Detail
Since TNFα and IGFBP-3 are key mediators of retinal damage and protection respectively in diabetic r... DisGeNET Detail
In a case-control study, the -238G>A (rs361525), -308G>A (rs1800629), and -857C>T (rs1799724) polymo... DisGeNET Detail
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The mechanisms may include the following pathways: [TGFB1 or TNFA]-[IL1B]-[pre-eclampsia]; [TNFA or ... DisGeNET Detail
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In this study, 14 single nucleotide variants (SNVs) in genes coding for interleukin-1β, interleukin-... DisGeNET Detail
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Tumor necrosis factor gene polymorphisms and endometriosis in Asians: a systematic review and meta-a... DisGeNET Detail
Behavior of tumor necrosis factor-α and tumor necrosis factor receptor 1/tumor necrosis factor recep... DisGeNET Detail
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Taken together, our data indicate that RIPK3 and autocrine production of TNFα contribute to cisplati... DisGeNET Detail
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Tumour necrosis factor-alpha (TNF-α) plays a critical role in the pathogenesis of periodontal diseas... DisGeNET Detail
The purpose of this study was to determine the differences in the distribution of TNF-α (-308) gene ... DisGeNET Detail
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The effect of a TNFα-producing adipose tissue-derived MSC (AT-MSC/hTNFα) was tested on the tumour ce... DisGeNET Detail
Recently, we have reported that the cardiac glycoside lanatoside C (Lan C) sensitizes glioma cells t... DisGeNET Detail
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioma cell invasion through i... DisGeNET Detail
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Furthermore, the basal intracellular protein levels of TNF in monocytes were lower in IgAN patients ... DisGeNET Detail
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Thus, ADCC-defective Fn14-blocking antibodies are not only possible novel GVL effect-sparing therape... DisGeNET Detail
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The group with Graves' disease also registered a higher frequency of the allele A in TNFA-308 G/A co... DisGeNET Detail
Increased level of IL-37 in patients with GD are associated with TNF-α, IL-6, IL-17 and disease acti... DisGeNET Detail
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To our knowledge, this is the first animal model showing both polyarthritis and heart disease as a d... DisGeNET Detail
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These results emphasize the therapeutic potential of anti-TNF drugs for the treatment of heart valve... DisGeNET Detail
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The overall findings of the study support the correlation of high-producer TNF-α genotypes combined ... DisGeNET Detail
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Assess IBD patients starting anti-TNF for the impact of preventive measures in HBV and/or HCV, and t... DisGeNET Detail
Alternative splicing-regulated protein of hepatitis B virus hacks the TNF-α-stimulated signaling pat... DisGeNET Detail
Tumor necrosis factor-alpha blockage therapy impairs hepatitis B viral clearance and enhances T-cell... DisGeNET Detail
The relationship between TNF alpha gene polymorphisms (-238/-308), TNF RII VNTR (p75) and outcomes o... DisGeNET Detail
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Combined impact of hepatitis C virus genotype 1 and interleukin-6 and tumor necrosis factor-α polymo... DisGeNET Detail
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Herpes virus entry mediator (HVEM), also known as tumour necrosis factor receptor (TNFR) superfamily... DisGeNET Detail
TNF-α was by far the most prominent cytokine in the supernatant and also within HSV-2-infected MDDCs... DisGeNET Detail
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During acute HIV infection, circulating Gal-9 was detected as early as 5 days after quantifiable HIV... DisGeNET Detail
High producer haplotype (CAG) of -863C/A, -308G/A and -238G/A polymorphisms in the promoter region o... DisGeNET Detail
Role of TNF block genetic variants in HIV-associated sensory neuropathy in black Southern Africans. DisGeNET Detail
In HIV-infected men, semen bacterial load correlated with seven pro-inflammatory semen cytokines, in... DisGeNET Detail
As this response was inhibited by a blocking anti-TNFα antibody, drug targeting HIV ssRNA-driven TLR... DisGeNET Detail
The indirect mechanism by which Tat activates the HERV-Ws through induction of TNFα could add a new ... DisGeNET Detail
Cardiac morbidity in an HIV-1 lipodystrophy patient cohort expressing the TNF-α-238 G/A single nucle... DisGeNET Detail
Genetic variation in the promoter region of pro-inflammatory cytokine TNF-α in perinatal HIV transmi... DisGeNET Detail
Herpes simplex virus type 2-infected dendritic cells produce TNF-α, which enhances CCR5 expression a... DisGeNET Detail
Genetic polymorphism of tumor necrosis factor promoter region and susceptibility to develop Hodgkin ... DisGeNET Detail
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Modulation of hyperglycemia and TNFα-mediated inflammation by helichrysum and grapefruit extracts in... DisGeNET Detail
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We confirmed that the plasma sP‑selectin levels were increased in patients with obesity (particularl... DisGeNET Detail
Adamts7 expression was induced in response to injury and hyperlipidemia but was absent at later time... DisGeNET Detail
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We observed that the frequency of CCR7-expressing TH1/TH17 effector lymphocytes increased during act... DisGeNET Detail
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The tumour suppressing effect of AT-MSC/hTNFα on A375 melanoma xenografts was monitored in an immuno... DisGeNET Detail
Despite the small number of patients in our cohort, our results are quite encouraging in view of the... DisGeNET Detail
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In addition, the cytokines IL-1β, IL-6 and IFN-γ may be potential targets for treating patients with... DisGeNET Detail
TNFα overexpression has been associated with several chronic inflammatory diseases, including psoria... DisGeNET Detail
SIRT1 expression was downregulated in control LPMC by tumor necrosis factor (TNF)-α and interleukin ... DisGeNET Detail
Sera from 25 anti-tumor necrosis factor naive patients with inflammatory bowel disease were used to ... DisGeNET Detail
Impact of surveillance of hepatitis b and hepatitis c in patients with inflammatory bowel disease un... DisGeNET Detail
IL-17A alone weakly affects the transcriptome of intestinal epithelial cells but strongly modulates ... DisGeNET Detail
These data may be useful prognostically as predictors of early response to anti-tumor necrosis facto... DisGeNET Detail
MicroRNA-346 mediates tumor necrosis factor α-induced downregulation of gut epithelial vitamin D rec... DisGeNET Detail
Opposite effects of interferon regulatory factor 1 and osteopontin on the apoptosis of epithelial ce... DisGeNET Detail
Additionally, polymorphisms of TNF-α gene are known to affect the gene expression level and particul... DisGeNET Detail
Tumor necrosis factor superfamily (TNFSF) proteins are involved in the genesis of inflammatory bowel... DisGeNET Detail
Although inhibition of tumor necrosis factor has been highly successful as a strategy in treating IB... DisGeNET Detail
Reverse transcription-PCR analysis showed that RANTES, Toll-like receptor 9, and IL-4 expression lev... DisGeNET Detail
Ablation of tumor necrosis factor is associated with decreased inflammation and alterations of the m... DisGeNET Detail
Thus, ADCC-defective Fn14-blocking antibodies are not only possible novel GVL effect-sparing therape... DisGeNET Detail
We summarize recent progress in the pharmacogenetics of IBD with respect to partitioning patient res... DisGeNET Detail
In 55 subjects with paired exacerbation data, qPCR bacterial load fold change at exacerbation in M c... DisGeNET Detail
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Systemic inflammation, as indicated by TNF-α inflammatory gene expression in peripheral blood monocy... DisGeNET Detail
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Additionally, polymorphisms of TNF-α gene are known to affect the gene expression level and particul... DisGeNET Detail
Further, ablation of SP-D had no effect on the ischemia-induced increase in TNF mRNA production one ... DisGeNET Detail
Our results support clinical trial data showing that PsA skin and joint disease are similarly respon... DisGeNET Detail
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Tumour necrosis factor-a (TNF-α) is an important cytokine involved in initiation and progression of ... DisGeNET Detail
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Association of tumour necrosis factor-α polymorphism in patients with end stage renal disease. DisGeNET Detail
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Association of leishmaniasis with TNF alpha promoter and SLC11A1 gene polymorphisms in patients of t... DisGeNET Detail
None of the TNF-α alleles and genotypes was associated either to CL or to VL. DisGeNET Detail
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Visceral leishmaniasis (VL) is associated with increased circulating levels of multiple pro-inflamma... DisGeNET Detail
None of the TNF-α alleles and genotypes was associated either to CL or to VL. DisGeNET Detail
In both cases lower TNF levels correlates with subjects carrying the risk C-allele, (p = 0.0453 and ... DisGeNET Detail
Association of TNF -1031 C/C as a potential protection marker for leprosy development in Amazonas st... DisGeNET Detail
Association of TNF-α-(308(GG)), IL-10(-819(TT)), IL-10(-1082(GG)) and IL-1R1(+1970(CC)) genotypes wi... DisGeNET Detail
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Targeting tmTNF-α by C1 resulted in leukemia cell killing via antibody-dependent cell-mediated and c... DisGeNET Detail
The aim of this study is to explore the spatial association of critical genomic elements in the effe... DisGeNET Detail
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Donors with HLA-B*58:01/TNFα − 308A haplotype are unfavorable to haploidentical hematopoietic stem c... DisGeNET Detail
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No significant difference in gene expression was detected between AML BM-MSCs compared to normal BM-... DisGeNET Detail
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Paradoxically, numerous studies have reported new-onset psoriasis and lichen planus following TNFα a... DisGeNET Detail
The contribution of genetic determinants such as the TNF-α 238G/A SNP to lipodystrophy, may provide ... DisGeNET Detail
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Genetic heterogeneity in the TNFα and IL1β gene promoters influences the risk of HCC in patients wit... DisGeNET Detail
Our study suggests that CB2R agonists have the potential to treat BT and various relevant abnormalit... DisGeNET Detail
Liver cirrhosis was associated with a -238 TNF-α polymorphism in these patients. DisGeNET Detail
To assess the contribution of tumor necrosis factor (TNF)β +252 polymorphisms to risk and prognosis ... DisGeNET Detail
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Clinical studies evaluating combination therapy of carvedilol with a TNF-α inhibitor to treat patien... DisGeNET Detail
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Based on the TNF-α-mediated genes that were dysregulated in lung tumors, we developed a prognostic g... DisGeNET Detail
Since chronic local activation of proinflammatory cytokines including TNF-α in resident renal cells ... DisGeNET Detail
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Since chronic local activation of proinflammatory cytokines including TNF-α in resident renal cells ... DisGeNET Detail
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Since chronic local activation of proinflammatory cytokines including TNF-α in resident renal cells ... DisGeNET Detail
Association of TLR4 (D299G, T399I), TLR9 -1486T>C, TIRAP S180L and TNF-α promoter (-1031, -863, -857... DisGeNET Detail
Serum VEGF level in the active SLE group was significantly higher than that in the control group and... DisGeNET Detail
Association of TNF-α with impaired migration capacity of mesenchymal stem cells in patients with sys... DisGeNET Detail
Tumor necrosis factor-α synergistically enhances polyinosinic-polycytidylic acid-induced toll-like r... DisGeNET Detail
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The association between the polymorphisms of TNF-α and non-Hodgkin lymphoma: a meta-analysis. DisGeNET Detail
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PDLIM5, S100A10 and TNF mRNA showed also an interesting pattern of expression with regards to MDE ev... DisGeNET Detail
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IFN-gamma and TNF associated with severe falciparum malaria infection in Saudi pregnant women. DisGeNET Detail
DDX39B (BAT1), TNF and IL6 gene polymorphisms and association with clinical outcomes of patients wit... DisGeNET Detail
Tumor necrosis factor-related apoptosis inducing ligand gene polymorphisms are correlated with gastr... DisGeNET Detail
Association between TNF-α-308 G/A gene polymorphism and gastric cancer risk: a systematic review and... DisGeNET Detail
Clinical study on gastric cancer susceptibility genes IL-10-1082 and TNF-α. DisGeNET Detail
These results suggest that claudin 1 is an important messenger that regulates TNF-α-induced gene exp... DisGeNET Detail
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Genetically engineered mesenchymal stromal cells producing TNFα have tumour suppressing effect on hu... DisGeNET Detail
We identified DNA copy-number gain and constitutive ubiquitination by a TNFα autocrine loop mechanis... DisGeNET Detail
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We reasoned that the anti-inflammatory actions of mesenchymal stromal cells (MSCs) and further antit... DisGeNET Detail
Furthermore, CCF polyphones significantly ameliorated both HFD-induced metabolic disorders, such as ... DisGeNET Detail
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Tumor necrosis factor receptor-associated periodic syndrome (TRAPS), formerly known as familial Hibe... DisGeNET Detail
Infliximab (IFX), a known monoclonal antibody against tumor necrosis factor-α (TNF-α), is used to tr... DisGeNET Detail
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To replicate and extend recent findings in a Turkish population of associations between chronic rhin... DisGeNET Detail
Stimulated PBMC-produced IFN-γ and TNF-α are associated with altered relapse risk in multiple sclero... DisGeNET Detail
Genetic variation in PBMC-produced IFN-γ and TNF-α associations with relapse in multiple sclerosis. DisGeNET Detail
We also demonstrate upregulation of CB1 and CB2 and increased IL-1β, IL-6 and TNF-α mRNA in blood of... DisGeNET Detail
Finally, we show that necroptosis mediates oligodendrocyte degeneration induced by TNF-α and that in... DisGeNET Detail
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The influence of the pro-inflammatory environment is discussed, particularly the role of TNF-α and T... DisGeNET Detail
B cells produce less IL-10, IL-6 and TNF-α in myasthenia gravis. DisGeNET Detail
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We highlight granuloma heterogeneity that emerges in the context of infection, the functional conseq... DisGeNET Detail
Control of Mycobacterial Infections in Mice Expressing Human Tumor Necrosis Factor (TNF) but Not Mou... DisGeNET Detail
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Plasma concentrations of interleukin 6, interleukin 15, and tumor necrosis factor α were elevated in... DisGeNET Detail
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Elevations of interleukin (IL)-6, IL-8, granulocyte- colony stimulating factor (G-CSF), and tumor ne... DisGeNET Detail
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Tumor necrosis factor-α-inducible protein-1 (TNFAIP1) plays a role in DNA synthesis, DNA repair, cel... DisGeNET Detail
The interaction of tumor necrosis factor-α (TNF-α) with its receptors: TNFRSF1A and TNFRSF1B is crit... DisGeNET Detail
A positive correlation was also obtained between TNF-α and CD44 expression, and co-upregulation of T... DisGeNET Detail
Taken together, these findings demonstrate that TIPE2 was able to suppress TNF-α-induced hepatocellu... DisGeNET Detail
Based on the recent findings that metastatic tumour cells adopt unique mechanisms of evading apoptos... DisGeNET Detail
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Tumor necrosis factor-alpha is a potential diagnostic biomarker for chronic neuropathic pain after s... DisGeNET Detail
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In the present study, the inflammatory cytokine, tumor necrosis factor‑α (TNF‑α) upregulated CXCR4 e... DisGeNET Detail
TNFα sensitizes neuroblastoma cells to FasL-, cisplatin- and etoposide-induced cell death by NF-κB-m... DisGeNET Detail
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No association was found between OCD or obsessive-compulsive symptoms and the studied TNF polymorphi... DisGeNET Detail
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Our results suggest that the TNFα gene variants play a role in the etiology of hand OA. DisGeNET Detail
Our results suggested that the TNF-α -G308A polymorphism were associated with an increased risk of O... DisGeNET Detail
Our study aimed to evaluate the in vitro effect of canakinumab on human osteoarthritic (OA) chondroc... DisGeNET Detail
In addition, we investigated the correlation between serum TSLP concentrations and anti-citrullinate... DisGeNET Detail
Our results thus indicated that suppression of TNFα activity is an effective strategy for OA treatme... DisGeNET Detail
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Tumor necrosis factor-related apoptosis-inducing ligand induces cytotoxicity specific to osteosarcom... DisGeNET Detail
Anti-tumor necrosis factor therapy inhibits lung metastasis in an osteosarcoma cell line. DisGeNET Detail
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In vitro and in vivo studies have highlighted different molecular mechanisms that regulate tumor nec... DisGeNET Detail
The effect of a TNFα-producing adipose tissue-derived MSC (AT-MSC/hTNFα) was tested on the tumour ce... DisGeNET Detail
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Administration of MSCs alone significantly reduced pancreatic injury and inflammation, as reflected ... DisGeNET Detail
The CART-33 infusion alone induced rigorous chills and fevers; drastic fluctuations of his preexisti... DisGeNET Detail
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Contrary to this, TNF-α levels were unchanged upon MAP stimulation regardless of NOD2 genotype and M... DisGeNET Detail
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TNFA-308G>A (rs1800629) and TNFA-1031T>C (rs1799964), which are responsible for increased TNFA trans... DisGeNET Detail
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Tumour necrosis factor-alpha (TNF-α) plays a critical role in the pathogenesis of periodontal diseas... DisGeNET Detail
The purpose of this study was to determine the differences in the distribution of TNF-α (-308) gene ... DisGeNET Detail
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TNF-α gene promoter polymorphisms contribute to periodontitis susceptibility: evidence from 46 studi... DisGeNET Detail
The TNF-α -308G/A AA genotype was associated with increased CP risk in Asians, non-smoking Asians an... DisGeNET Detail
The results of this study revealed an association between TNF-α (-308) allele 2 frequency and aggres... DisGeNET Detail
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Taken together, our data demonstrate that HIF-1α acts downstream of TNF-α to inhibit VASP expression... DisGeNET Detail
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Tumor necrosis factor-alpha and polycystic ovarian syndrome: a clinical, biochemical, and molecular ... DisGeNET Detail
Family association study between tumour necrosis factor a gene polymorphisms and polycystic ovary sy... DisGeNET Detail
Associations between TNF-α and interleukin gene polymorphisms with polycystic ovary syndrome risk: a... DisGeNET Detail
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Prevalence of human Papillomavirus DNA in eyebrow hairs plucked from patients with psoriasis treated... DisGeNET Detail
Psoriasis (Ps) is an autoimmune disease characterized by keratinocyte hyperproliferation and chronic... DisGeNET Detail
TNFα overexpression has been associated with several chronic inflammatory diseases, including psoria... DisGeNET Detail
Biological drugs such as the tumour necrosis factor inhibitors have revolutionized the treatment of ... DisGeNET Detail
Additionally, the effects of the anti-TNFα drug Etanercept on metabolic profiles were investigated i... DisGeNET Detail
TNF-α plays a crucial role in psoriasis; therefore, TNF inhibition has become a gold standard for th... DisGeNET Detail
Hyper-production of TNF-α is documented in psoriasis. DisGeNET Detail
Methotrexate is a first-line systemic agent for treating of psoriasis, although its onset of effects... DisGeNET Detail
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The results of the present study suggest that the DEGs identified, including chemokine‑related genes... DisGeNET Detail
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Tumor necrosis factor superfamily 14 (LIGHT) controls thymic stromal lymphopoietin to drive pulmonar... DisGeNET Detail
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Investigation of TNF-alpha gene (G308A) and GSTP1 gene (Ilel05Val) polymorphisms in Turkish patients... DisGeNET Detail
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Our results identify IGF2BP1 as a critical translational regulator of cIAP1-mediated apoptotic resis... DisGeNET Detail
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Tumor necrosis factor-alpha 308G>A polymorphism and risk of rheumatic heart disease: a meta-analysis... DisGeNET Detail
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We report significant increases in PPARγ, SREBP1, IL-6 and TNFα, and decreases in PPARα and C/EPBα a... DisGeNET Detail
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Toll-like receptors (TLR) recognize pathogens and trigger the production of vigorous pro-inflammator... DisGeNET Detail
TNF-α, IL-6, and IL-8 cytokines and their association with TNF-α-308 G/A polymorphism and postoperat... DisGeNET Detail
The protection of female hearts against the dysfunction associated with sepsis is (at least in part)... DisGeNET Detail
In summary, this work provides the first in vivo evidence that administering BMMSCs or UCMSCs to rat... DisGeNET Detail
Modulation of TNF-α mRNA stability by human antigen R and miR181s in sepsis-induced immunoparalysis. DisGeNET Detail
Shedding of the tumor necrosis factor (TNF) receptor from the surface of hepatocytes during sepsis l... DisGeNET Detail
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Neutralization of tumor necrosis factor-α and IL-6 (both downstream of IL-17A) reduced skin lesions,... DisGeNET Detail
Treatment of K5.Stat3C mice with TNF-α or EGFR inhibitors attenuated the skin lesions, suggesting th... DisGeNET Detail
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Tumor necrosis factor (TNF)-alpha promoter polymorphisms in ankylosing spondylitis: comment on the a... DisGeNET Detail
Effects of tumor necrosis factor inhibitor on serum level of HLA-B27 and PDCD-1 in patients with ank... DisGeNET Detail
Tumor necrosis factor-α promoter -308/238 polymorphism association with less severe disease in ankyl... DisGeNET Detail
Runt-related transcription factor 3 (RUNX3), tumor necrosis factor family member-associated NF-κB ac... DisGeNET Detail
Effects of tumor necrosis factor-α inhibitors in mothers and daughters concordant for HLA-B27-positi... DisGeNET Detail
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While the elderly group exhibited robust changes in immune activity such as increased production of ... DisGeNET Detail
This paper aims to investigate the association between psychological stress and MS with respect to t... DisGeNET Detail
An association between stroke and TNF-α -308A allele has been suggested. DisGeNET Detail
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Association of the tumor necrosis factor -308 A/G promoter polymorphism with Tourette syndrome. DisGeNET Detail
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Moreover, during T. cruzi infection, this thymocyte subset expresses high levels of IL-17 and TNF-α ... DisGeNET Detail
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Peripheral blood mononuclear cells from 42 healthy controls (HCs) and 42 pulmonary tuberculosis (PTB... DisGeNET Detail
The combination of IFN-γ, TNF-α, and IL-2R, and the combination of TNF-α, IL-2R, CXCL9, and CXCL10 s... DisGeNET Detail
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TNF-α -308 GA/AA genotype was associated with a reduced risk of uveitis and better spinal function, ... DisGeNET Detail
New cytokine inhibitors targeting IL-1 and IL-6 appear to be effective especially for uveitis and CN... DisGeNET Detail
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The pre-treatment of HeLa monolayer with inactivated bacterial cells 24 hours before the viral infec... DisGeNET Detail
The combination of tumour necrosis factor-α -308A and interleukin-10 -1082G gene polymorphisms and i... DisGeNET Detail
Isolated PBMCs from O. volvulus-infected individuals (164 MF(+) and 46 a-MF) and non-infected volunt... DisGeNET Detail
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Conversely, tumor necrosis factor-α was significantly decreased in DEB (P = 0.0034). DisGeNET Detail
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B-cell activating factor-receptor specific activation of tumor necrosis factor receptor associated f... DisGeNET Detail
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Moreover, knockdown of tmTNF-α(+) expression rendered leukemia cells more sensitive to chemotherapy ... DisGeNET Detail
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The ability of PGA to induce TNF-α and IL-6 was retained in TLR4(-/-) but not TLR2(-/-) BMDMs. DisGeNET Detail
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To characterize tmTNF-α expression in acute leukemia (AL), normal hematopoietic cells, and nonhemato... DisGeNET Detail
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Alcohol abuse promotes the migration of bone marrow-derived cells (BMDCs) to the liver and then repr... DisGeNET Detail
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Recent evidence suggests that both NOX1 and DUOX2 species produce ROS in the gastrointestinal tract ... DisGeNET Detail
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The levels of inflammatory cytokines IL-6, IL-8, IL-1β and TNF-α in the HNE2 cell group after EBV in... DisGeNET Detail
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Role of TNF block genetic variants in HIV-associated sensory neuropathy in black Southern Africans. DisGeNET Detail
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These include strategies targeting chemokine pathways via CC chemokine receptors 1 and 2 to modulate... DisGeNET Detail
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We found an association between the risk of CMM and peripheral blood mononuclear cell methylation le... DisGeNET Detail
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We retrospectively compared the efficacy of standard platinum‑based chemotherapy with that of combin... DisGeNET Detail
Taken together, our data indicate that RIPK3 and autocrine production of TNFα contribute to cisplati... DisGeNET Detail
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Anti-tumor necrosis factor therapy inhibits lung metastasis in an osteosarcoma cell line. DisGeNET Detail
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The -308G>a polymorphism of the TNF gene is associated with proliferative diabetic retinopathy in Ca... DisGeNET Detail
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We confirmed that the plasma sP‑selectin levels were increased in patients with obesity (particularl... DisGeNET Detail
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LIM mineralization protein-1 suppresses TNF-α induced intervertebral disc degeneration by maintainin... DisGeNET Detail
We investigated whether expression of xylosyltransferase-1 (XT-1), a key enzyme in glycosaminoglycan... DisGeNET Detail
To examine whether electroacupuncture (EA) treatment inhibited cell apoptosis of intervertebral annu... DisGeNET Detail
We propose that during disc degeneration PHD2 may offer a therapeutic target to mitigate the deleter... DisGeNET Detail
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A standardized femur fracture was applied to wild type and human TNF-α transgenic mice (hTNFtg mice)... DisGeNET Detail
Spontaneous retrotransposon insertion into TNF 3'UTR causes heart valve disease and chronic polyarth... DisGeNET Detail
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Polymorphisms in the TNFA and IL6 genes represent risk factors for autoimmune thyroid disease. DisGeNET Detail
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Tumor necrosis factor-α-inducible protein-1 (TNFAIP1) plays a role in DNA synthesis, DNA repair, cel... DisGeNET Detail
The ability of tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) to regulate NF-κB ... DisGeNET Detail
The tomato diet significantly inhibited TNFα stimulated NF-κB activity in cultured PC3 cells, and mo... DisGeNET Detail
TRAF4, or tumor necrosis factor receptor-associated factor 4, is overexpressed in several cancers, s... DisGeNET Detail
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In control participants, the risk of developing dysplastic nevi was associated with methylation leve... DisGeNET Detail
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TNF-α, TNF-β and IL-10 gene polymorphism and association with oral lichen planus risk in Saudi patie... DisGeNET Detail
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Genetic association of IL-6, TNF-α and SDF-1 polymorphisms with serum cytokine levels in diabetic fo... DisGeNET Detail
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The aim of our study was to analyze TNF-α promoter gene polymorphisms as risk factors for pNETs usin... DisGeNET Detail
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ALCAM is a Novel Cytoplasmic Membrane Protein in TNF-α Stimulated Invasive Cholangiocarcinoma Cells. DisGeNET Detail
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These findings suggest that miR-509 has a critical role in brain metastasis of breast cancer by modu... DisGeNET Detail
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Associations between TNF-α-308A/G polymorphism and susceptibility with dermatomyositis: a meta-analy... DisGeNET Detail
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Since TNFα and IGFBP-3 are key mediators of retinal damage and protection respectively in diabetic r... DisGeNET Detail
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Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in panc... DisGeNET Detail
The aim of our study was to analyze TNF-α promoter gene polymorphisms as risk factors for pNETs usin... DisGeNET Detail
Recent evidence suggests that both NOX1 and DUOX2 species produce ROS in the gastrointestinal tract ... DisGeNET Detail
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TNF-α is expressed in human cherubism lesions, which contain a large number of tartrate-resistant ac... DisGeNET Detail
To investigate the expression of TNF-α, IFN-γ, TGF-β, and IL-4 in the spinal tuberculous focus and i... DisGeNET Detail
Loss of SH3 domain-binding protein 2 function suppresses bone destruction in tumor necrosis factor-d... DisGeNET Detail
Tumor necrosis factor (TNF) drives bone destruction, but it also inhibits new bone formation by indu... DisGeNET Detail
Synergistic effect of pro-inflammatory TNFα and IL-17 in periostin mediated collagen deposition: pot... DisGeNET Detail
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The consequence of VILI by H&E stain showed inducing lung congestion and increasing the expression o... DisGeNET Detail
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Our study validates the association of the TNF-α 238G/A SNP allelic variant with the development of ... DisGeNET Detail
Furthermore, the homeostasis model assessment of insulin resistance (HOMA-IR) index and serum proinf... DisGeNET Detail
Expression of tumor necrosis factor-alpha-mediated genes predicts recurrence-free survival in lung c... DisGeNET Detail
Meta-analysis of the associations between TNF-α or IL-6 gene polymorphisms and susceptibility to lun... DisGeNET Detail
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Furthermore, Sirt2−/− mice succumbed to TNF induced Systemic Inflammatory Response Syndrome (SIRS) m... DisGeNET Detail
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Toll-like receptors (TLR) recognize pathogens and trigger the production of vigorous pro-inflammator... DisGeNET Detail
TNF-α, IL-6, and IL-8 cytokines and their association with TNF-α-308 G/A polymorphism and postoperat... DisGeNET Detail
The protection of female hearts against the dysfunction associated with sepsis is (at least in part)... DisGeNET Detail
In summary, this work provides the first in vivo evidence that administering BMMSCs or UCMSCs to rat... DisGeNET Detail
Modulation of TNF-α mRNA stability by human antigen R and miR181s in sepsis-induced immunoparalysis. DisGeNET Detail
Shedding of the tumor necrosis factor (TNF) receptor from the surface of hepatocytes during sepsis l... DisGeNET Detail
This study evaluated the relationship between single-nucleotide polymorphisms in the promoter region... DisGeNET Detail
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TNF-like ligand 1A is associated with the pathogenesis of psoriasis vulgaris and contributes to IL-1... DisGeNET Detail
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Variations in the TNFα gene and their interactions with the IL4R and IL10 genes in relation to hand ... DisGeNET Detail
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Analysis of TNF-α (-308) polymorphism and gingival crevicular fluid TNF-α levels in aggressive and c... DisGeNET Detail
Since pDC, but not cDC, from pearl mice showed an impaired IFN-α and tumor necrosis factor-α product... DisGeNET Detail
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Early and exudative age-related macular degeneration is associated with increased plasma levels of s... DisGeNET Detail
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The two-week JWH133 treatment significantly decreased systemic/intestinal oxidative stress, TNFα and... DisGeNET Detail
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The effect of infliximab, a TNF-α inhibitor, on a metastatic osteosarcoma 143B cell growth and motil... DisGeNET Detail
The purpose of this study was to identify functional genetic variants in the promoter of tumor necro... DisGeNET Detail
To investigate the role of claudin 1 in the regulation of genes involved in cell migration and tumor... DisGeNET Detail
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Expression of TNF-α and CD44 is implicated in poor prognosis, cancer cell invasion, metastasis and r... DisGeNET Detail
CD70, a member of the TNF ligand superfamily, has been shown frequently overexpressed in clear cell ... DisGeNET Detail
A20, also known as tumor necrosis factor-α (TNFα)-induced protein 3 (TNFAIP3), has been identified a... DisGeNET Detail
Transmembrane TNF-α preferentially expressed by leukemia stem cells and blasts is a potent target fo... DisGeNET Detail
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Association between laryngeal squamous cell carcinoma and polymorphisms in tumor necrosis factor rel... DisGeNET Detail
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By contrast, upregulation of interleukin-2 (IL-2), IL-6, IL-8 and tumor necrosis factor-α (TNF-α) ex... DisGeNET Detail
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Re-expression of HPV16 E2 in SiHa (human cervical cancer) cells potentiates NF-κB activation induced... DisGeNET Detail
TNF-α -308 G/A as a risk marker of cervical cancer progression in the Polish population. DisGeNET Detail
Administration of antagonists against C5aR or TNF-α ameliorated MHV-3-induced FH. DisGeNET Detail
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Linear regression analysis of the parameters with body mass index (BMI) and metabolic syndrome compo... DisGeNET Detail
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Loss of FAK reduced invasion in murine arthritic synovial fibroblasts, but not migration or TNFα-ind... DisGeNET Detail
Therefore, global and CMV (NLV)-specific CD8(+) T cells that secrete interferon-γ, interleukin-2 and... DisGeNET Detail
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Homozygosity for the TNFR1A 36A allele and the TNFA-875T variant could act as a genetic factor assoc... DisGeNET Detail
To this end, we identified TNBC-driven molecular pathways such as the Janus kinase-signal transducer... DisGeNET Detail
The tumor necrosis factor (TNF) signaling pathway is a classical immune system pathway that plays a ... DisGeNET Detail
Using anti-TNF treatment and TNF-receptor-deficient mice, here we show that Bin cells are induced an... DisGeNET Detail
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The frequency of circulating CD14(+)HLA-DR(-/low) MDSCs; arginase-1 (Arg-1) expression; and plasma l... DisGeNET Detail
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Association of TNF-α -308 G > A and ACE I/D gene polymorphisms in hemodialysis patients with arterio... DisGeNET Detail
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We aimed to determine mRNA expressions of genes associated with local androgen synthesis and metabol... DisGeNET Detail
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Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in panc... DisGeNET Detail
The aim of our study was to analyze TNF-α promoter gene polymorphisms as risk factors for pNETs usin... DisGeNET Detail
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In this study, we explored whether human gingival-derived MSCs (G-MSCs) can migrate toward tongue sq... DisGeNET Detail
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To investigate the expression level of tumor necrosis factor receptor-associated factor 1 (TRAF1) in... DisGeNET Detail
Moreover, the activating effect of TNF-α was markedly augmented by the infection of Helicobacter pyl... DisGeNET Detail
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High levels of TNF-α influence fracture healing negatively, lead to reduced cartilage and more soft ... DisGeNET Detail
A protective association of TNF-α -308A allele and -308GA genotype against DHF/DSS was observed, whi... DisGeNET Detail
The NRIF3/DIF-1/FASTKD2 pathway acts as a death switch in breast and prostate cancer cells. DisGeNET Detail
Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-Troglitazone-induced Apoptosis in Pr... DisGeNET Detail
APRIL (a proliferation-inducing ligand) is a cytokine of the tumor necrosis factor family associated... DisGeNET Detail
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Relationship between tumor necrosis factor-α (TNFA) gene polymorphisms and cardiac sarcoidosis. DisGeNET Detail
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Tumor necrosis factor-α -308G/A gene polymorphism in Egyptian children with immune thrombocytopenic ... DisGeNET Detail
TNF-α promoter single nucleotide polymorphisms and haplotypes associate with susceptibility of immun... DisGeNET Detail
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In addition, decreased numbers of CD4+ and CD8+ T lymphocytes and increased levels of TNF-α, IL-6 an... DisGeNET Detail
Serum levels of interleukin 8, chemokine (C-C motif) ligand 3, and tumor necrosis factor-α correlate... DisGeNET Detail
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Variations in the TNFα gene and their interactions with the IL4R and IL10 genes in relation to hand ... DisGeNET Detail
Meta-analysis of tumor necrosis factor alpha -308 polymorphism and knee osteoarthritis risk. DisGeNET Detail
Since chronic local activation of proinflammatory cytokines including TNF-α in resident renal cells ... DisGeNET Detail
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Here we investigated genetic associations with HIV-SN in 342 black Southern Africans (190 cases and ... DisGeNET Detail
Receiver operating characteristics (ROC) analysis revealed that TNF-α had great potential advantages... DisGeNET Detail
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Thus, circadian rhythms, nest construction, IL-1β and TNF-α, and glial fibrillary acidic protein (GF... DisGeNET Detail
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Transcript levels of TNFα were significantly higher by 1.4-fold and 2.1-fold in blood cells of overw... DisGeNET Detail
Tumor necrosis factor-alpha -308 G>A polymorphism, adherence to Mediterranean diet, and risk of over... DisGeNET Detail
The aim of the present study was to evaluate the potential association between dietary nutrients and... DisGeNET Detail
Human papillomavirus and chlamydia trachomatis infections in rheumatoid arthritis under anti-TNF the... DisGeNET Detail
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An updated meta-analysis of the association between tumor necrosis factor-α -308G/A polymorphism and... DisGeNET Detail
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Polymorphism at the TNF-alpha gene interacts with Mediterranean diet to influence triglyceride metab... DisGeNET Detail
Association of polymorphisms in stress-related TNFα and NPY genes with the metabolic syndrome in Han... DisGeNET Detail
Linear regression analysis of the parameters with body mass index (BMI) and metabolic syndrome compo... DisGeNET Detail
Association of tumor necrosis factor-α promoter G-308A gene polymorphism with increased triglyceride... DisGeNET Detail
Apart from the well-known pharmacological effects of TNF inhibitors on autoimmune disorders, interes... DisGeNET Detail
This study was performed to explore the relationships between the sequence variants of TNF-A-308, IF... DisGeNET Detail
The aim of this study was to assess whether two-years treatment with Pirfenidone influences necroinf... DisGeNET Detail
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Taken together, our data indicate that RIPK3 and autocrine production of TNFα contribute to cisplati... DisGeNET Detail
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The role of tumor necrosis factor-α (TNF-α), a cytokine involved in inflammation processes, has been... DisGeNET Detail
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Interleukin-6 and tumor necrosis factor-alpha gene polymorphisms in chronic idiopathic urticaria. DisGeNET Detail
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Tumor necrosis factor-related apoptosis-inducing ligand induces cytotoxicity specific to osteosarcom... DisGeNET Detail
Anti-tumor necrosis factor therapy inhibits lung metastasis in an osteosarcoma cell line. DisGeNET Detail
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The NRIF3/DIF-1/FASTKD2 pathway acts as a death switch in breast and prostate cancer cells. DisGeNET Detail
Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-Troglitazone-induced Apoptosis in Pr... DisGeNET Detail
Using a matrigel invasion assay, we showed that TSS significantly attenuated invasive rates in TNF-α... DisGeNET Detail
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A significant association was found between the allele A in TNFA-308 G/A and Hashimoto's thyroiditis... DisGeNET Detail
The effect of a TNFα-producing adipose tissue-derived MSC (AT-MSC/hTNFα) was tested on the tumour ce... DisGeNET Detail
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Tumor necrosis factor receptor-associated factor 4 (TRAF4) is upregulated in various subtypes of bre... DisGeNET Detail
To better understand the roles of single nucleotide polymorphisms (SNPs) in the TNF-α, TNFRSF1A and ... DisGeNET Detail
Association between the tumor necrosis factor alpha gene -308G> A polymorphism and the risk of breas... DisGeNET Detail
Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce apoptosis in a w... DisGeNET Detail
The overexpression of CMTM1_v17 in the breast cancer cell line MDA-MB-231 promoted cell proliferatio... DisGeNET Detail
The important function of FASN in the drug tolerance of breast cancer may be due to the following me... DisGeNET Detail
In the current study we examined the expression and function of HOTAIR in MCF-7-TNR cells, a derivat... DisGeNET Detail
In conclusion, our findings support a contributing role of certain TNF-α and TLR genes in both breas... DisGeNET Detail
Tumor necrosis factor-α sensitizes breast cancer cells to natural products with proteasome-inhibitor... DisGeNET Detail
TNFα was increased upon overexpression of miR562, which was reversed when ANXA1 was co-transfected I... DisGeNET Detail
NFKB1, NFKBIA, IL-8, IL-10, and TNF polymorphisms could serve as useful predictive biomarkers for br... DisGeNET Detail
Melanoma A375 and breast carcinoma SKBR3 cells were the most sensitive, and their proliferation in v... DisGeNET Detail
In this study, we examined protein arginine methyltransferase 5 (PRMT5) and tumor necrosis factor re... DisGeNET Detail
By testing a panel of different cytokines, chemokines, growth factors and other compounds, including... DisGeNET Detail
Regulation of the inflammatory profile of stromal cells in human breast cancer: prominent roles for ... DisGeNET Detail
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Allantopyrone A, a recently identified α-pyrone metabolite from an endophytic fungus, was found to i... DisGeNET Detail
Expression of tumor necrosis factor-alpha-mediated genes predicts recurrence-free survival in lung c... DisGeNET Detail
In conclusion, TNF-α induced CLDN1 expression is regulated by the PKCδ-iPLA2-PGE2-PPARγ signaling ca... DisGeNET Detail
Meta-analysis of the associations between TNF-α or IL-6 gene polymorphisms and susceptibility to lun... DisGeNET Detail
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New cytokine inhibitors targeting IL-1 and IL-6 appear to be effective especially for uveitis and CN... DisGeNET Detail
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In search for novel strategies in colon cancer treatment, we investigated the unique ability of plat... DisGeNET Detail
The effect of a TNFα-producing adipose tissue-derived MSC (AT-MSC/hTNFα) was tested on the tumour ce... DisGeNET Detail
Tumor necrosis factor-related apoptosis inducing ligand gene polymorphisms are correlated with gastr... DisGeNET Detail
Association between TNF-α-308 G/A gene polymorphism and gastric cancer risk: a systematic review and... DisGeNET Detail
Clinical study on gastric cancer susceptibility genes IL-10-1082 and TNF-α. DisGeNET Detail
These results suggest that claudin 1 is an important messenger that regulates TNF-α-induced gene exp... DisGeNET Detail
In this study, we investigated the effects and molecular mechanisms of metformin in sensitizing tumo... DisGeNET Detail
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In the present study, the inflammatory cytokine, tumor necrosis factor‑α (TNF‑α) upregulated CXCR4 e... DisGeNET Detail
TNFα sensitizes neuroblastoma cells to FasL-, cisplatin- and etoposide-induced cell death by NF-κB-m... DisGeNET Detail
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Variations in three cytokine genes (i.e., interleukin (IL) 1 beta, IL1 receptor 2 (IL1R2), nuclear f... DisGeNET Detail
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In addition, apoA-I reversed the TNF-mediated suppression of lymphatic endothelial cell migration an... DisGeNET Detail
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Genetic variation in TNFA predicts protection from severe bacterial infections in patients with end-... DisGeNET Detail
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Neutralization of tumor necrosis factor-α and IL-6 (both downstream of IL-17A) reduced skin lesions,... DisGeNET Detail
Tetrahydroxystilbene glucoside improves TNF-α-induced endothelial dysfunction: involvement of TGFβ/S... DisGeNET Detail
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Here we report recurrent point mutations and genomic gains of TNFRSF1B, encoding the tumor necrosis ... DisGeNET Detail
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TRAP1/Hsp75 (tumor necrosis factor receptor-associated protein 1), a paralogue of the Hsp90 family, ... DisGeNET Detail
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Our results highlight that genes IL-8 and TNF have close relationship with acute ischemic stroke, an... DisGeNET Detail
TNFα gene G-308A polymorphism and the risk of ischemic stroke. DisGeNET Detail
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Levels of Dkk-1 were similar in SpA SF and RA SF and were not correlated with TNF and IL-1β levels. DisGeNET Detail
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Loss of SH3 domain-binding protein 2 function suppresses bone destruction in tumor necrosis factor-d... DisGeNET Detail
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In vitro and in vivo studies have highlighted different molecular mechanisms that regulate tumor nec... DisGeNET Detail
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The main aim was to investigate the potential prognostic significance of tumor necrosis factor-like ... DisGeNET Detail
Through our genomics-based approach, we found topological differences in the kinetics and magnitude ... DisGeNET Detail
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Based on this knowledge, we conceived to use modified MSC to deliver tumor necrosis factor-related a... DisGeNET Detail
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Tumor necrosis factor receptor-associated periodic syndrome (TRAPS), formerly known as familial Hibe... DisGeNET Detail
Tumour necrosis factor receptor I blockade shows that TNF-dependent and TNF-independent mechanisms s... DisGeNET Detail
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Variations in three cytokine genes (i.e., interleukin (IL) 1 beta, IL1 receptor 2 (IL1R2), nuclear f... DisGeNET Detail
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These results reveal a crucial role for TNFα/TNFR2 axis in the protection of the skin against DUOX1-... DisGeNET Detail
Therefore, the TNF-α/IL-32 axis may be a potential therapeutic target for airway inflammatory diseas... DisGeNET Detail
These data provide evidence that using gene expression modules related to inflammatory disease may p... DisGeNET Detail
Tumor necrosis factor (TNF) blockage therapy is effective for the treatment of many autoimmune infla... DisGeNET Detail
TNFα overexpression has been associated with several chronic inflammatory diseases, including psoria... DisGeNET Detail
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Plasma concentrations of interleukin 6, interleukin 15, and tumor necrosis factor α were elevated in... DisGeNET Detail
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Elevated PPM1A levels led to attenuation of hPXR inhibition by tumor necrosis factor-α and cyclin-de... DisGeNET Detail
In the in vitro experiments, LPS preconditioning of ASCs enhanced the mRNA expression levels of inte... DisGeNET Detail
Tumor necrosis factor-inducible gene 6 promotes liver regeneration in mice with acute liver injury. DisGeNET Detail
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In view of the crucial role of TNF and intestinal cell death in graft-versus-host disease (GVHD) and... DisGeNET Detail
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Expression of IL-1, TNF-α and COX-2 increased with the stage of the disease in both serous and mucin... DisGeNET Detail
Finally, upstream signaling pathways were analyzed, with TNF-α and EGF being the main inductors of M... DisGeNET Detail
These results not only suggest that GSK-3β overexpression and nuclear localization contribute to TNF... DisGeNET Detail
In the present study, by analysis of genome-wide patterns of c-Rel-dependent gene expression, we wer... DisGeNET Detail
Here we show in human PDAC that a high percentage of infiltrating pY323(+) T cells was associated wi... DisGeNET Detail
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Association of TNF-α, TNFRSF1A and TNFRSF1B gene polymorphisms with the risk of sporadic breast canc... DisGeNET Detail
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Transmembrane TNF-α preferentially expressed by leukemia stem cells and blasts is a potent target fo... DisGeNET Detail
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The tumor necrosis factor-α -238G/A and IL-6 -572G/C gene polymorphisms and the risk of idiopathic d... DisGeNET Detail
Polymorphisms of tumor necrosis factor-alpha and interleukin-6 gene and C-reactive protein profiles ... DisGeNET Detail
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Genetic association of IL-6, TNF-α and SDF-1 polymorphisms with serum cytokine levels in diabetic fo... DisGeNET Detail
Exposure of MSCs to TNF-α led to potent CCL2-induced migration of monocytic cells, a process that ma... DisGeNET Detail
ONO-8430506 also decreased plasma TNF-α and G-CSF cytokine levels by >70% and leukocyte infiltration... DisGeNET Detail
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Previous studies demonstrated that the vascular endothelial growth inhibitor (VEGI), a member of the... DisGeNET Detail
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Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal c... DisGeNET Detail
Consistently, we found that, in human colorectal cancer tissues, high levels of TNF-α correlates wit... DisGeNET Detail
Previously, we demonstrated that tumor necrosis factor (TNF) induced DAPK-mediated apoptosis in colo... DisGeNET Detail
Increased expression of tumor necrosis factor-α is associated with advanced colorectal cancer stages... DisGeNET Detail
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In this study, 14 single nucleotide variants (SNVs) in genes coding for interleukin-1β, interleukin-... DisGeNET Detail
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Genetic heterogeneity in the TNFα and IL1β gene promoters influences the risk of HCC in patients wit... DisGeNET Detail
Our study suggests that CB2R agonists have the potential to treat BT and various relevant abnormalit... DisGeNET Detail
To assess the contribution of tumor necrosis factor (TNF)β +252 polymorphisms to risk and prognosis ... DisGeNET Detail
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Accordingly, it decreased expression of ER-α target PS2 (P<0.01) and increased expression of ER-β ta... DisGeNET Detail
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Valine at position 11 also was associated with higher all-cause mortality in patients with inflammat... DisGeNET Detail
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Association of monocyte tumor necrosis factor α expression and serum inflammatory biomarkers with wa... DisGeNET Detail
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Our study validates the association of the TNF-α 238G/A SNP allelic variant with the development of ... DisGeNET Detail
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Genetic polymorphisms of TNFA and IL-1A and generalized aggressive periodontitis. DisGeNET Detail
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This suggests that the protective effect of Fn14 blockade in allo-HCT is based on the protection of ... DisGeNET Detail
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The combination of tumour necrosis factor-α -308A and interleukin-10 -1082G gene polymorphisms and i... DisGeNET Detail
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In this study, we investigated the influence of the rd8 mutation on the retinal pathology that we pr... DisGeNET Detail
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Diagnostic potential of differentially expressed Homer1, IL-1β, and TNF-α in coronary artery disease... DisGeNET Detail
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Donors with HLA-B*58:01/TNFα − 308A haplotype are unfavorable to haploidentical hematopoietic stem c... DisGeNET Detail
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A proliferation-inducing ligand (APRIL) is a tumor-necrosis factor (TNF) family member and is a nove... DisGeNET Detail
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Genetic heterogeneity in the TNFα and IL1β gene promoters influences the risk of HCC in patients wit... DisGeNET Detail
Rocaglamide overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatoce... DisGeNET Detail
Taken together, these findings demonstrate that TIPE2 was able to suppress TNF-α-induced hepatocellu... DisGeNET Detail
Tumor necrosis factor-alpha gene -308G > A polymorphism alters the risk of hepatocellular carcinoma ... DisGeNET Detail
Heat shock protein 20 (HSPB6) regulates TNF-α-induced intracellular signaling pathway in human hepat... DisGeNET Detail
To assess the contribution of tumor necrosis factor (TNF)β +252 polymorphisms to risk and prognosis ... DisGeNET Detail
Haplotype analysis revealed that TNF-α (-308A; -238A) was significantly associated to HBV chronic in... DisGeNET Detail
Tumor Necrosis Factor-α Genotypes Are Associated with Hepatocellular Carcinoma Risk in Taiwanese Mal... DisGeNET Detail
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Association of tumour necrosis factor-α polymorphism in patients with end stage renal disease. DisGeNET Detail
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Impact of surveillance of hepatitis b and hepatitis c in patients with inflammatory bowel disease un... DisGeNET Detail
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TNF-α -308 G>A polymorphism and risk of bone marrow failure syndrome: A meta-analysis. DisGeNET Detail
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Our results highlight that genes IL-8 and TNF have close relationship with acute ischemic stroke, an... DisGeNET Detail
TNFα gene G-308A polymorphism and the risk of ischemic stroke. DisGeNET Detail
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To this end, we identified TNBC-driven molecular pathways such as the Janus kinase-signal transducer... DisGeNET Detail
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TNFA Haplotype Genetic Testing Improves HLA in Estimating the Risk of Celiac Disease in Children. DisGeNET Detail
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At the gene level, TNF (rs76917; OR T=1.35, 95% CI 1.13-1.63; P=0.0034) was identified as the only g... DisGeNET Detail
At the gene level, TNF (rs76917; OR T=1.35, 95% CI 1.13-1.63; P=0.0034) was identified as the only g... DisGeNET Detail
Only tumor necrosis factor alpha rs800629 was associated with anorexia (odds ratio: 0.46; 95% confid... DisGeNET Detail
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The cytokine tumor necrosis factor-alpha (TNF-α) is elevated in the blood of Alzheimer's disease (AD... DisGeNET Detail
More importantly, changes in Aβ oligomer and sTNFR levels accurately differentiated mild AD patients... DisGeNET Detail
Tumor necrosis factor receptor II (TNFRII) is one of the TNF receptor superfamily members and our re... DisGeNET Detail
Although the potential adverse effects of TNF-based AD therapies have been of concerns, here we summ... DisGeNET Detail
TNF-α -308G/A and IL-8 -251T/A were significantly associated with AD and IL-1β +3953C/T with late-li... DisGeNET Detail
The result of this meta-analysis suggests that TNF-alpha G308A polymorphism may be associated with t... DisGeNET Detail
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Variations in three cytokine genes (i.e., interleukin (IL) 1 beta, IL1 receptor 2 (IL1R2), nuclear f... DisGeNET Detail
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Moreover, miR-144-3p mimics (agomir) enhanced the expression of inflammatory factors, including IL-1... DisGeNET Detail
Thus, TNFα induced miR-155 may serve as a negative feedback regulator in endothelial inflammation in... DisGeNET Detail
Activation of CD137 (tumor necrosis factor receptor super family 9) promotes inflammation and diseas... DisGeNET Detail
Osteoprotegerin (OPG) is a secretory glycoprotein that belongs to the tumor necrosis factor receptor... DisGeNET Detail
Furthermore, sortilin also seems to be involved in the development of atherosclerosis, by mechanisms... DisGeNET Detail
The atherosclerosis risk factor TNF was used as a positive control in this study. DisGeNET Detail
Our results propose that TNF-α -308 G > A genotype may be a potential genetic marker on HD patients ... DisGeNET Detail
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Our results provide the evidence that the administration of 5-LOX inhibitors is able to ameliorate T... DisGeNET Detail
FAK inhibitors reduce synovial fibroblast invasion and migration, but synovial fibroblast migration ... DisGeNET Detail
The tumour necrosis factor (TNF)-α-induced proteins (TNFAIP)9 and TNFAIP3 play an important pathogen... DisGeNET Detail
Antagonists of tumor necrosis factor-α (TNFα) and IL-1β were equally effective in suppressing arthri... DisGeNET Detail
TNF-transgenic mice develop inflammatory-erosive arthritis associated with disruption of draining ly... DisGeNET Detail
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Biologic anti-tumour necrosis factor agents, such as etanercept, infliximab and adalimumab, are effe... DisGeNET Detail
We determined the expression of ILT4 and analysed the relationship with the expression of costimulat... DisGeNET Detail
We aimed to characterize the PsA genotype by gene expression profile and to research the effect in g... DisGeNET Detail
Our results support clinical trial data showing that PsA skin and joint disease are similarly respon... DisGeNET Detail
TNF-blocking agents, non-biological disease-modifying anti-rheumatic drugs (nbDMARDs) and non-steroi... DisGeNET Detail
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Recently, the tumor necrosis factor superfamily member (TNFSF) 14/LIGHT has been recognized as a key... DisGeNET Detail
Therefore, the aim of the study was to assess the amount and activity of MMP-9 in context of pro-inf... DisGeNET Detail
Effects of TNF-α polymorphisms on asthma risk: a systematic review and meta-analysis. DisGeNET Detail
Polymorphisms of tumor necrosis factor-α, transforming growth factor-β, and interleukin-10 in asthma... DisGeNET Detail
Healthy and asthmatic ASM cells were treated with TNF-α/IFN-γ for 24 hours in the presence or absenc... DisGeNET Detail
Gene polymorphisms of tumor necrosis factor alpha and antioxidant enzymes in bronchial asthma. DisGeNET Detail
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Moreover, miR-144-3p mimics (agomir) enhanced the expression of inflammatory factors, including IL-1... DisGeNET Detail
Thus, TNFα induced miR-155 may serve as a negative feedback regulator in endothelial inflammation in... DisGeNET Detail
Activation of CD137 (tumor necrosis factor receptor super family 9) promotes inflammation and diseas... DisGeNET Detail
Osteoprotegerin (OPG) is a secretory glycoprotein that belongs to the tumor necrosis factor receptor... DisGeNET Detail
Furthermore, sortilin also seems to be involved in the development of atherosclerosis, by mechanisms... DisGeNET Detail
The atherosclerosis risk factor TNF was used as a positive control in this study. DisGeNET Detail
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Cytokines, that is, interleukin-1β and tumor necrosis factor-α from MDSCs are required for B16 melan... DisGeNET Detail
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Genetic variation in TNFA predicts protection from severe bacterial infections in patients with end-... DisGeNET Detail
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Tumour necrosis factor-alpha gene polymorphisms in Iranian patients with biliary atresia. DisGeNET Detail
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In the present paper we tested the enrichment of molecular pathways related to inflammatory cascades... DisGeNET Detail
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In this study, we investigated the effects and molecular mechanisms of metformin in sensitizing tumo... DisGeNET Detail
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iNKT cells from subjects with bone and cardiovascular impairment expressed high levels of CD161 and ... DisGeNET Detail
LIGHT, a TNF superfamily member, is involved in T-cell homeostasis and erosive bone disease associat... DisGeNET Detail
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Tumor necrosis factor receptor-associated factor 4 (TRAF4) is upregulated in various subtypes of bre... DisGeNET Detail
To better understand the roles of single nucleotide polymorphisms (SNPs) in the TNF-α, TNFRSF1A and ... DisGeNET Detail
Association between the tumor necrosis factor alpha gene -308G> A polymorphism and the risk of breas... DisGeNET Detail
Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce apoptosis in a w... DisGeNET Detail
The overexpression of CMTM1_v17 in the breast cancer cell line MDA-MB-231 promoted cell proliferatio... DisGeNET Detail
The important function of FASN in the drug tolerance of breast cancer may be due to the following me... DisGeNET Detail
In the current study we examined the expression and function of HOTAIR in MCF-7-TNR cells, a derivat... DisGeNET Detail
In conclusion, our findings support a contributing role of certain TNF-α and TLR genes in both breas... DisGeNET Detail
Tumor necrosis factor-α sensitizes breast cancer cells to natural products with proteasome-inhibitor... DisGeNET Detail
TNFα was increased upon overexpression of miR562, which was reversed when ANXA1 was co-transfected I... DisGeNET Detail
NFKB1, NFKBIA, IL-8, IL-10, and TNF polymorphisms could serve as useful predictive biomarkers for br... DisGeNET Detail
Melanoma A375 and breast carcinoma SKBR3 cells were the most sensitive, and their proliferation in v... DisGeNET Detail
In this study, we examined protein arginine methyltransferase 5 (PRMT5) and tumor necrosis factor re... DisGeNET Detail
By testing a panel of different cytokines, chemokines, growth factors and other compounds, including... DisGeNET Detail
Regulation of the inflammatory profile of stromal cells in human breast cancer: prominent roles for ... DisGeNET Detail
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Regulation of hepatic cardiolipin metabolism by TNFα: Implication in cancer cachexia. DisGeNET Detail
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In search for novel strategies in colon cancer treatment, we investigated the unique ability of plat... DisGeNET Detail
Tumour necrosis factor alpha (TNF-α) inhibitors are associated with an increased risk of infections ... DisGeNET Detail
There may be a small risk of lymphoma and possibly skin cancer with anti-tumor necrosis factor agent... DisGeNET Detail
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Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising agent for anticancer ... DisGeNET Detail
In conclusion, the combination chemotherapy of VNR + DIF may be a promising treatment for NSCLC pati... DisGeNET Detail
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Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs386543959 dbSNP
Genome
hg19
Position
chr6:31,543,342-31,546,113
Variant Type
snv
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