aortic valve stenosis

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Information
Disease name
aortic valve stenosis
Disease ID
DOID:1712
Description
"An aortic valve disease that is characterized by narrowing of the heart's aortic valve opening." [url:http\://en.wikipedia.org/wiki/Aortic_valve_stenosis, url:https\://rarediseases.info.nih.gov/diseases/5830/aortic-valve-stenosis]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT04722250 Active, not recruiting N/A SMall Annuli Randomized To Evolut™ or SAPIEN™ Trial April 2, 2021 December 2027
NCT06192706 Active, not recruiting N/A Clinical Investigation for the Foldax Tria Aortic Heart Valve- India January 1, 2022 September 1, 2024
NCT04665596 Active, not recruiting N/A Valvosoft First-In-Human Study in Severe Symptomatic Aortic Stenosis December 23, 2019 May 15, 2024
NCT04655248 Active, not recruiting ACURATE neo2™ Post Market Clinical Follow up Study December 16, 2020 December 31, 2026
NCT02661451 Active, not recruiting N/A Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD) September 2016 February 2025
NCT03411304 Active, not recruiting Aortic Stenosis: Determinants and Prognostic Value of Preoperative Left Ventricular Remodeling After Valvular Replacement December 5, 2017 June 2025
NCT02701283 Active, not recruiting N/A Medtronic Evolut Transcatheter Aortic Valve Replacement in Low Risk Patients March 2016 March 2026
NCT04649099 Active, not recruiting N/A The Leaflex™ Standalone Study Protocol September 2, 2020 December 2024
NCT03112980 Active, not recruiting N/A Randomized Trial of TAVI vs. SAVR in Patients With Severe Aortic Valve Stenosis at Low to Intermediate Risk of Mortality May 10, 2017 January 2028
NCT05052684 Active, not recruiting N/A The Leaflex™ Brazilian Standalone Study October 3, 2022 December 31, 2024
NCT03699345 Active, not recruiting CENTERA PMCF: Post-Market Follow-up of the CENTERA Transcatheter Heart Valve System January 7, 2019 September 2024
NCT03517436 Active, not recruiting N/A ExCEED: CENTERA THV System in Intermediate Risk Patients Who Have Symptomatic, Severe, Calcific, Aortic Stenosis September 18, 2018 July 2030
NCT02732691 Active, not recruiting N/A JENAVALVE AS EFS TRIAL: Pericardial TAVR Aortic Stenosis Study October 21, 2016 April 2024
NCT03444259 Active, not recruiting Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients February 1, 2016 December 31, 2029
NCT03481387 Active, not recruiting N/A PERCEVAL S Valve Clinical Study for Chinese Registration January 26, 2018 February 25, 2024
NCT03851068 Active, not recruiting N/A Early Feasibility Study for the Foldax Tria Aortic Heart Valve June 18, 2019 December 2026
NCT04160130 Active, not recruiting N/A RHEIA (Randomized researcH in womEn All Comers With Aortic Stenosis) November 29, 2019 June 2024
NCT05024279 Active, not recruiting N/A Left Bundle Branch Area Pacing in Patients After TAVR August 6, 2021 April 2025
NCT04281771 Active, not recruiting N/A Assessment of Paravalvular Leak After TAVI by Hemodynamic Measurements and Cardiac MRI September 17, 2019 October 28, 2026
NCT04555967 Active, not recruiting SAPIEN 3 Ultra System PMCF June 30, 2020 November 2026
NCT03666741 Active, not recruiting Inspiris Resilia Durability Registry April 26, 2019 May 2025
NCT05531578 Active, not recruiting N/A Transfemoral Implant of Inovare® Transcatheter Valve September 11, 2020 December 30, 2028
NCT03305094 Active, not recruiting N/A The Effect of Remote Ischemic Preconditioning in Aortic Valve Replacement Surgery April 11, 2014 December 1, 2024
NCT02426307 Active, not recruiting Subclinical Aortic Valve Bioprosthesis Thrombosis Assessed With 4D CT April 2015 April 2030
NCT02825134 Active, not recruiting N/A Comparison of TAVR With SAVR in Younger Low Surgical Risk Patients With Severe Aortic Stenosis June 30, 2016 June 2029
NCT02434263 Active, not recruiting N/A A Clinical Evaluation of the HYDRA Self Expanding Transcatheter Aortic Valve August 13, 2015 July 2025
NCT05235568 Active, not recruiting N/A VALVOSOFT® Pivotal Study June 15, 2022 August 15, 2024
NCT03471065 Active, not recruiting N/A The SAPIEN 3 Ultra System in Intermediate Risk Patients With Symptomatic, Severe Aortic Stenosis June 1, 2018 February 2025
NCT04869631 Active, not recruiting Screening for Amyloidosis Before Aortic Valve Elective Replacement February 1, 2021 March 31, 2028
NCT04514250 Active, not recruiting Stress Aortic Valve Index for Assessing Risk in Aortic Valve Stenosis Patients April 14, 2021 October 1, 2028
NCT05171712 Active, not recruiting N/A Portico and Navitor India Clinical Trial May 6, 2022 June 2025
NCT03910751 Active, not recruiting POLESTAR Trial - An International Multi-center Early Discharge TAVI Program April 1, 2019 February 1, 2024
NCT04860752 Active, not recruiting SAPIEN 3 Ultra EU PMS April 20, 2021 July 2024
NCT03411317 Active, not recruiting Aortic Stenosis: Determinants of Progression, Severity and Left Ventricular Remodeling December 11, 2017 December 2025
NCT04836897 Active, not recruiting N/A PrizValve® Transcatheter Aortic Valve Replacement Study January 19, 2021 June 2028
NCT03094143 Active, not recruiting N/A Early Valve Replacement Guided by Biomarkers of LV Decompensation in Asymptomatic Patients With Severe AS July 21, 2017 June 30, 2032
NCT03561805 Active, not recruiting N/A Prolonged Continuous ECG Monitoring Prior to Transcatheter Aortic Valve Implantation June 1, 2017 June 1, 2026
NCT03863132 Active, not recruiting N/A accuRate Evaluation of Benefit With Optimal Medical Treatment With or Without Transcatheter Valve Repair of PARADOXical Low Flow Low Gradient Aortic Stenosis July 3, 2019 March 1, 2028
NCT03520101 Active, not recruiting N/A Comparison of the Balloon-Expandable Edwards Valve and Self-Expandable CoreValve Evolut R or Evolut PRO System for the Treatment of Small, Severely Dysfunctional Surgical Aortic Bioprotheses. The 'LYTEN' Trial May 10, 2017 May 31, 2024
NCT02260466 Active, not recruiting N/A Prevalence and Post-surgical Outcomes of CARdiac Wild-type TransthyrEtin amyloidoSIs in Elderly Patients With Aortic steNosis Referred for Valvular Replacement. October 2014 December 31, 2024
NCT03058627 Active, not recruiting N/A Revascularization in Patients Undergoing Transcatheter Aortic Valve Implantation September 15, 2017 November 15, 2027
NCT03876964 Available J-Valve Compassionate Use
NCT01720342 Completed Enable® Aortic Sutureless Bioprosthesis Evaluation February 2013 April 2018
NCT01721642 Completed Phase 1/Phase 2 A Pilot Study to Evaluate the Safety and Efficacy of the Apica Access, Stabilization and Closure (ASC™) Device May 2012 March 2013
NCT00005199 Completed Balloon Valvuloplasty Registry June 1987 November 1994
NCT01789567 Completed N/A Engager Direct Aortic Clinical Study May 2013 June 2015
NCT01802788 Completed 5 Year Observation of Patients With PORTICO Valves April 16, 2013 October 19, 2022
NCT00081666 Completed Logical Analysis of Data and Cardiac Surgery Risk July 2004 June 2007
NCT05641584 Completed Is Monocyte/HDL Ratio a Predictor of Mortality in Aortic Valve Surgery May 10, 2022 July 10, 2022
NCT05603429 Completed Investigation of Myocardial Protection Level With Specific Cardioplegia Methods in Cardiac Surgery October 13, 2022 August 8, 2023
NCT05580237 Completed Pressure Gradient vs. Flow Relationships in Patients With Symptomatic Valvular Aortic Stenosis September 1, 2019 December 1, 2023
NCT01843426 Completed N/A Aortic Stenosis Pre-Transcatheter Aortic Valve Replacement (TAVR) Procedure CT Scan February 2013 September 25, 2017
NCT01852552 Completed Costs, Cognitive Abilities and Quality of Life After Transcatheter Aortic Valve Implantation and Surgical Aortic Valve Replacement December 2011 January 2016
NCT05503199 Completed N/A Comparison of Strategies for Vascular Access Closure After Transcatheter Aortic Valve Implantation October 1, 2022 April 18, 2024
NCT01959503 Completed N/A Progel Vascular Sealant November 2013 December 2014
NCT01972555 Completed N/A Cardiac Function After Minimally Invasive Aortic Valve Implantation October 2013 July 2015
NCT01991444 Completed CGA-TAVI Registry to Evaluate the Predictive Value of a CGA in Predicting TAVI Outcomes February 2014 February 2017
NCT00005190 Completed Reproduction and Survival After Cardiac Defect Repair July 1986 December 1998
NCT05439395 Completed Study on the Clinical Performance of Steelex® Sternum Set for Sternal Closure May 18, 2022 April 7, 2023
NCT05308173 Completed Aortic Valve replAcement in eLective Patients From aOrtic Valve multiceNter Registry January 1, 2015 June 30, 2021
NCT02031302 Completed RESPOND Post Market Study May 27, 2014 May 18, 2021
NCT02049203 Completed Phase 1 Safety of Ataciguat in Patients With Moderate Calcific Aortic Valve Stenosis January 2014 March 2015
NCT02070731 Completed N/A DEFLECT III: A Prospective, Randomized Evaluation of the TriGuard™ HDH Embolic Deflection Device During TAVI February 2014 April 2015
NCT02073851 Completed N/A DEFLECT II: A Study to Evaluate the Safety and Performance of the TriGuard™HDH in Patients Undergoing TAVR January 2014 September 2014
NCT02073864 Completed A Study to Evaluate the Neuro-embolic Consequences of TAVR November 2013 August 2015
NCT05241821 Completed Acute STROke Complicating TAVI - Management and Outcomes June 1, 2021 February 5, 2022
NCT02099942 Completed Post-Market Surveillance Registry to Monitor Performance and Safety of V8 Device March 2014 December 2015
NCT02127580 Completed Balloon Expandable Transcatheter Aortic Valve Implantation Without Predilation of the Aortic Valve April 2014 May 2016
NCT02146755 Completed Improving Echo Measurements in the Diagnosis of Aortic Stenosis August 2013 December 2015
NCT02149654 Completed Engager Align Post-market Clinical Study May 2014 January 2017
NCT02157142 Completed N/A HLT transfemOral Replacement of aortIc Valve Via transcatherteriZatiON August 2014 October 2019
NCT02162069 Completed N/A Coronary and Structural Interventions - Transcatheter Aortic Valve Replacement June 2014 December 2018
NCT02193035 Completed N/A Microparticles in Severe Aortic Stenosis June 2014 June 2015
NCT02209298 Completed CoreValve VIVA Study Evaluation of the Clinical Outcomes of CoreValve in Degenerative Surgical Aortic Bioprosthesis. November 2014 December 3, 2018
NCT05082337 Completed N/A The SAVVY Guidewire in Transcatheter Aortic Valve Replacement Procedures October 8, 2021 December 28, 2021
NCT02241109 Completed N/A Predicting Aortic Stenosis Progression by Measuring Serum Calcification Propensity September 30, 2014 February 28, 2017
NCT02241447 Completed Quality of Care in AS IMPULSE Study August 8, 2014 May 31, 2018
NCT02249000 Completed N/A BIOVALVE - I / II Clincial Investigation September 2014 May 2023
NCT02272621 Completed N/A Bleeding in Partial Upper Hemisternotomy Versus Full Sternotomy Aortic Valve Replacement November 2013 October 2020
NCT02280824 Completed Phase 1 Transcaval Access for Transcatheter Aortic Valve Replacement in People With No Good Options for Aortic Access October 30, 2014 December 28, 2018
NCT02287662 Completed N/A The Multidisciplinary, Multimodality, But Minimalist Approach to Transfemoral Transcatheter Aortic Valve Replacement March 2015 May 2018
NCT02289339 Completed Everyday Practice With Transcatheter Aortic Valve Implantation November 2007 May 20, 2018
NCT02308150 Completed The Asian Transcatheter Aortic Valve Replacement Registry December 2014 September 24, 2019
NCT02308566 Completed Phase 4 Cerebral Embolic Load in Patients Undergoing Surgical Aortic Valve Replacement: A Comparison of the Conventional With the Minimized Extracorporeal Circulation Technique Using Transcranial Doppler Ultrasound June 2011 June 2016
NCT02316587 Completed Assessment of Myocardial Fibrosis in Aortic STenosis March 2014 December 2016
NCT02324140 Completed Inflammatory Response in Aortic Valve Replacement June 2012 May 2015
NCT02337140 Completed N/A Indication of Permanent Cardiac Parcing After Tanscatheter Aortic Valve Implantation August 2014 August 2016
NCT02375282 Completed N/A Physical and Functional Recovery From Cardiac Surgery in Hospitalized Patients: A Feasibility Pilot Study March 2015 July 2016
NCT02394184 Completed The Bicuspid Aortic Stenosis Following Transcatheter Aortic Valve Replacement Registry May 2015 September 24, 2019
NCT02395107 Completed Left Atrial Volume Index in Asymptomatic Aortic Stenosis January 2014 June 2016
NCT02408003 Completed N/A Changes in Cardiac Deformation Following Physiologic Alterations and Inotropic Support. March 2014 May 2017
NCT05002088 Completed Portico Valve-in-Valve Retrospective Registry October 21, 2021 December 29, 2023
NCT02448927 Completed Phase 3 The preDIlatation in tRanscathEter aortiC Valve implanTation Trial May 2015 May 2, 2018
NCT02472106 Completed Impact of Postdilatation With the InterValve V8 Aortic Valvuloplasty Balloon Following TAVI Procedure June 2015 August 2016
NCT02481258 Completed Phase 2 A Study Evaluating the Effects of Ataciguat (HMR1766) on Aortic Valve Calcification June 2015 December 1, 2019
NCT02510482 Completed Biological Variation of Cardiac Biomarkers in Aortic Valve Stenosis August 2015 October 16, 2017
NCT04810195 Completed Early neo2 Registry of the Acurate neo2 TAVI Prosthesis September 1, 2020 March 15, 2022
NCT02551588 Completed Valvular Aortic Stenosis: Study of Myocardiac Fibrosis by Magnetic Resonance Imagery December 2012 November 2015
NCT02559011 Completed Assessment of Arrhythmias in Patients Undergoing Transcatheter Aortic Valve Implantation Using a Small Insertable Cardiac Monitoring Device March 2016 November 16, 2020
NCT02592369 Completed CoreValve™ Evolut R™ FORWARD Study January 2016 February 6, 2020
NCT04704258 Completed N/A NAUTILUS CE-mark Trial of the FLOWer Cerebral Embolic Protection Device May 3, 2021 June 6, 2023
NCT02624934 Completed Podocan and Wnt Pathway in Left Ventricular Remodeling of Aortic Stenosis October 2015 June 2020
NCT02671474 Completed N/A Valve Leaflet Motion in Sutureless Bioprosthetic Aortic Valves January 2016 May 2016
NCT02726087 Completed N/A Quality of Life After Ministernotomy Versus Full Sternotomy Aortic Valve Replacement March 20, 2016 October 20, 2019
NCT02727504 Completed Low Flow Low Gradient Aortic Stenosis Relevance of the (re)Search for a Contractile Reserve May 11, 2016 January 6, 2020
NCT02729519 Completed N/A TAVI Without Balloon Predilatation (of the Aortic Valve ) SAPIEN 3 June 8, 2016 August 9, 2018
NCT02738853 Completed N/A The Medtronic TAVR 2.0 US Clinical Study April 2016 December 15, 2021
NCT02746809 Completed N/A Medtronic CoreValve Evolut R U.S. Clinical Study (Evolut 34R Addendum) June 2016 December 15, 2021
NCT02758964 Completed Evaluation of Cerebral Thrombembolism After TAVR September 2016 January 2019
NCT04557345 Completed Evaluation of the Inflammatory Response in Post-operated Aortic Valve Replacement Patients. January 1, 1990 August 1, 2020
NCT02781896 Completed N/A Direct Left Ventricular Rapid Pacing Via the Valve Delivery Guide-wire in TAVI May 12, 2017 June 29, 2018
NCT02792452 Completed Clinical Value of Stress Echocardiography in Moderate Aortic Stenosis September 2016 December 31, 2019
NCT02805309 Completed N/A Home-Based Exercise Program For Recovery After Transcatheter Aortic Valve Replacement August 1, 2017 May 6, 2020
NCT02815514 Completed German TAVI-Register January 2009 December 2016
NCT02817789 Completed Phase 3 Safety Profile Evaluation of TICagrelor Alone Compared to a Combination of Lysine Acetylsalicylate-Clopidogrel in the Context of Transcatheter Aortic Valve Implantation (TAVI) May 9, 2016 May 30, 2018
NCT04548726 Completed Hemodynamic Matched Comparison of the Balloon-Expandable Transcatheter Heart Valves Myval and Sapien-3 for the Treatment of Aortic Stenosis June 1, 2018 September 30, 2020
NCT02833948 Completed Phase 3 Comparison of a Rivaroxaban-based Strategy With an Antiplatelet-based Strategy Following Successful TAVR for the Prevention of Leaflet Thickening and Reduced Leaflet Motion as Evaluated by Four-dimensional, Volume-rendered Computed Tomography (4DCT) May 2016 March 6, 2019
NCT04527367 Completed Epidemiology and Long-term Outcome of Patients With VHD January 2006 January 2022
NCT02838680 Completed N/A Transfemoral Replacement of Aortic Valve With HLT MeriDIAN Valve Feasibility Trial CANADA December 2016 October 31, 2022
NCT02847546 Completed Evaluation of the BARD® True™ Flow Valvuloplasty Perfusion Catheter for Aortic Valve Dilatation September 2016 October 2016
NCT04503655 Completed N/A Multicenter Study Evaluating the Efficacy of an Intervention Aimed at Reducing the Length of Stay After Transfemoral Transcatheter Aortic Valve Implantation December 16, 2020 February 9, 2022
NCT04459208 Completed N/A Randomized Comparison of Catheter-based Strategies for Interventional Access Site Closure During Transfemoral Transcatheter Aortic Valve Implantation June 26, 2020 August 4, 2021
NCT04437303 Completed Phase 4 Periprocedural Continuation Versus Interruption of Oral Anticoagulant Drugs During Transcatheter Aortic Valve Implantation (POPular PAUSE TAVI) November 25, 2020 May 22, 2024
NCT02971020 Completed N/A Evaluating the Risk of Cognitive Impairment After Surgical and Transcatheter Aortic Valve Replacement May 2016 March 21, 2018
NCT02974660 Completed Phase 4 Protamine Sulfate During Transcatheter Aortic Valve Implantation December 2016 September 2020
NCT02989558 Completed Phase 3 A Trial to Assess the Safety and Efficacy of Prophylactic TicagrelOr With Acetylsalicylic Acid Versus CLopidogrel With Acetylsalicylic Acid in the Development of Cerebrovascular EMbolic Events During TAVI December 2016 February 1, 2021
NCT04400513 Completed Development of an Algorithm to Differentiate Heart Murmurs Using Electronic Stethoscopes June 25, 2020 December 31, 2021
NCT03011346 Completed N/A Safety and Efficacy of the Symetis ACURATE Neo/TF Compared to the Edwards SAPIEN 3 Bioprosthesis. February 8, 2017 February 16, 2022
NCT04385459 Completed Severe Aortic Valve Stenosis and Concomitant Coronary Artery Disease in Patients Undergoing TAVI December 13, 2018 December 24, 2020
NCT03056573 Completed N/A Assessment of the St Jude Medical Portico Resheathable Aortic Valve System-Alternative Access March 29, 2017 July 5, 2019
NCT03667248 Completed Sizing of the PERCEVAL® Sutureless Aortic Valve Prosthesis Using the CT: a Feasibility Study May 2, 2018 March 31, 2019
NCT03715894 Completed Prospective Arm of Conduct - Edwards SAPIEN3 PPI Registry December 1, 2018 March 30, 2023
NCT03740425 Completed Transfusion Requirements in Transcatheter Aortic Valve Implantation (TRITAVI) Study January 1, 2018 March 1, 2019
NCT03753126 Completed N/A Stent Geometry in Sutureless Bioprosthetic Valves January 2016 November 2018
NCT03769545 Completed Mortality Post-TAVI and Correlation With Haemodynamic Parameters. January 1, 2008 December 31, 2017
NCT03779620 Completed N/A Valvosoft First-In-Man Study in Severe Symptomatic Aortic Stenosis March 13, 2019 September 27, 2023
NCT03863899 Completed N/A Analgesia in Patients Undergoing Transfemoral Transcatheter Aortic Valve Implantation (TF-TAVI) July 2, 2018 December 31, 2019
NCT03807921 Completed Phase 4 Anticoagulation for Aortic Bioprosthesis (ANTIPRO) January 1, 2019 December 31, 2019
NCT03811119 Completed N/A Manta™ Versus Suture-based Closure After Transcatheter Aortic Valve Implantation Trial October 30, 2018 April 30, 2020
NCT00636987 Completed N/A Aortic or Mitral Valve Replacement With the Biocor and Biocor Supra April 2007 March 2016
NCT05904912 Completed N/A PENG Block forTranscatheter Aortic Valve Implantation June 10, 2023 December 7, 2023
NCT00727181 Completed N/A An Observational, Prospective Evaluation of the Trifecta™ Valve November 2007 December 2010
NCT00820599 Completed N/A PREVAIL-TF: Transfemoral Placement of Aortic Balloon Expandable Transcatheter Valves Trial (Europe) December 2008 March 2016
NCT00965679 Completed X-ray Fluoroscopy Fused With Computed Tomography (XFC) Technical Development August 6, 2009 May 27, 2010
NCT01015612 Completed N/A CoreValve® System Australia/New Zealand Clinical Study August 2008 September 2016
NCT01051310 Completed N/A Medtronic CoreValve REDO Study June 2008 January 2011
NCT01051518 Completed N/A Clinical Evaluation of Percutaneous Implantation of the Medtronic CoreValve Aortic Valve Prosthesis (18Fr-Study) May 2006 June 2013
NCT01092442 Completed CryoValve SG Pulmonary Human Heart Valve Post Clearance Study January 2010 December 2014
NCT01113983 Completed N/A PREVAIL-J - Transfemoral & Transapical Placement of Aortic Balloon Expandable Transcatheter Valves Trial (Japan) April 1, 2010 May 2016
NCT05750927 Completed Aortic Stenosis With COmplex PCI (ASCOP) Features Retrospective Registry on Contemporary Management and Outcomes December 1, 2022 December 31, 2023
NCT01171625 Completed N/A Carpentier-Edwards PERIMOUNT Magna Ease Pericardial Bioprosthesis, Model 3300TFX October 2007 September 2018
NCT01236469 Completed CryoValve® SG Aortic Human Heart Valve Combination Study June 2010 February 2012
NCT01238835 Completed N/A PREVAIL-TA: Placement of Aortic Balloon Expandable Transcatheter Valves Trial (Europe) September 2009 March 2016
NCT01251328 Completed N/A Near INfrared Spectroscopy in Aortic valvE ReplacemenT December 2010 April 2012
NCT01348438 Completed N/A Transapical Implantation of the Medtronic Engager Transcatheter Aortic Valve Implantation System - The Engager European Pivotal Trial September 12, 2011 January 25, 2018
NCT01383720 Completed N/A REpositionable Percutaneous Replacement of Stenotic Aortic Valve Through Implantation of Lotus™ Valve SystEm April 2012 May 9, 2017
NCT01390129 Completed N/A Remote Ischemic Preconditioning in Aortic Valve Surgery July 2011 October 2012
NCT01419015 Completed N/A PREVAIL-20J - Transfemoral Placement of 20mm Aortic Balloon Expandable Transcatheter Valve Trial June 2011 December 2017
NCT01437098 Completed N/A Clinical Evaluation of MDT-2111 in Subjects With Symptomatic Severe Aortic Stenosis October 2011 November 27, 2018
NCT01445171 Completed N/A Surgical Treatment of Aortic Stenosis With a Next Generation Surgical Aortic Valve January 2010 December 2017
NCT01497418 Completed Long Term Follow-up of the 23mm Portico™ Aortic Valve Implant and the St. Jude Medical Transfemoral Delivery System December 2011 March 2014
NCT01514994 Completed N/A Valvuloplasty Scoring Balloon Catheter First-in-Man Study June 2012 September 2015
NCT01593917 Completed Trifecta™ Long Term Follow-Up (LTFU) Study July 2, 2012 September 26, 2019
NCT01624870 Completed CoreValve Advance-II Study: Prospective International Post-market Study October 2011 March 2014
NCT01634269 Completed N/A Clinical Evaluation of MDT-2111 in Subjects With Small Aortic Annuli and Symptomatic Severe Aortic Stenosis July 2012 September 2019
NCT01635244 Completed N/A Hemodynamic Comparison of Tissue Aortic Valves July 2012 December 2015
NCT01642134 Completed Phase 4 Dual Antiplatelet Therapy Versus Oral Anticoagulation for a Short Time to Prevent Cerebral Embolism After TAVI April 2013 June 30, 2019
NCT01651052 Completed N/A Clinical Trial of the Edwards Aortic Bioprosthesis, Model 11000 July 2011 July 2018
NCT05672823 Completed N/A Upper Extremity Versus Lower Extremity Accessory Access Sites During Transcatheter Aortic Valve Implantation November 28, 2022 December 15, 2023
NCT05672160 Completed Overal Survival After TAVI According to Sarcopenia January 1, 2022 January 2, 2023
NCT01700439 Completed N/A Surgical Treatment of Aortic Stenosis With a Next Generation, Rapid Deployment Surgical Aortic Valve September 26, 2012 May 26, 2021
NCT05662748 Completed Comparison Between Manta and Prostar Closure Devices January 20, 2020 March 30, 2021
NCT04333875 Completed Morbidity and Mortality Due to Deferral of Aortic Valve Replacement in Patients With Severe Aortic Stenosis March 20, 2020 April 30, 2021
NCT03326778 Completed Registry to Gather Long-time Results After Surgical Aortic Valve Replacement With a "Rapid Deployment Aortic Valve Prothesis (Edwards Intuity) Combined With Bypss Surgery (CABG) November 26, 2017 July 1, 2020
NCT03347032 Completed N/A Remote Ischemic Preconditioning for Renal Protection in TAVI February 13, 2018 December 30, 2018
NCT00475267 Completed N/A Aortic Valve Replacement With Trifecta(TM) May 2007 January 2012
NCT04274751 Completed Comparison of Transaxillary and Transfemoral Fully-percutaneous Approaches for Transcatheter Aortic Valve Implantation July 1, 2019 June 30, 2020
NCT03385915 Completed Finnish Registry of Transcatheter and Surgical Aortic Valve Replacement for Aortic Valve Stenosis: FinnValve Registry December 1, 2017 March 9, 2020
NCT03417011 Completed FORWARD PRO Study Interventional Post-market Study With the Evolut™ PRO System February 26, 2018 February 26, 2024
NCT03422770 Completed N/A Ultrasonic Markers for Myocardial Fibrosis and Prognosis in Aortic Stenosis January 9, 2018 June 30, 2020
NCT00475709 Completed N/A Aortic Valve Replacement With Trifecta(TM) June 2007 January 2012
NCT03458806 Completed Phono- and Electrocardiogram Assisted Detection of Valvular Disease February 22, 2018 November 11, 2019
NCT03483051 Completed Phase 2 Targeting Pulsatile Load to Increase Exercise Capacity and Quality of Life After Aortic Valve Replacement for Severe Aortic Stenosis (PULSE AS) May 1, 2018 May 23, 2019
NCT03497611 Completed Edwards SAPIEN 3 PPI Registry April 30, 2018 March 3, 2019
NCT04131127 Completed Sentinel Low Risk Registry January 7, 2020 August 19, 2020
NCT03570190 Completed Registry to Evaluate the Impact of a Valve Coordinator on Aortic Stenosis / TAVI Outcome - (German Pilot) December 20, 2018 December 19, 2019
NCT04103931 Completed N/A Impact of a Patient Decision Aid for Treatment of Aortic Stenosis September 23, 2019 September 1, 2021
NCT03588247 Completed Cerebrovascular EveNts in Patients Undergoing TranscathetER Aortic Valve Implantation With Balloon-expandable Valves Versus Self-expandable Valves. August 1, 2017 January 1, 2023
NCT04096859 Completed PremiCron Suture for Cardiac Valve Repair November 22, 2019 January 13, 2022
NCT03617406 Completed N/A Volume Challenge Added to DSE in the Diagnosis of Severe LFLGAS May 31, 2018 December 31, 2020
NCT04053192 Completed Evaluation of BAV in Different Hemodynamic Entities of Severe AS June 1, 2018 August 31, 2019
NCT04012060 Completed N/A Patient Reported Health-Related Quality of Life After Limited Access and Conventional Aortic Valve Replacement June 13, 2016 July 7, 2020
NCT03966417 Completed N/A Exercise Training After Transcatheter Aortic Valve Implantation June 18, 2019 December 1, 2020
NCT03950440 Completed Assessing the Incidence of Postoperative Delirium Following Aortic Valve Replacement September 23, 2018 July 9, 2020
NCT03074838 Completed N/A Inflammatory Response to Aortic Valve Replacement December 1, 2012 December 31, 2013
NCT03087552 Completed Mini-invasive Balloon Aortic Valvuloplasty March 11, 2017 April 20, 2021
NCT03107897 Completed N/A Prehabilitation for Patients Undergoing Transcatheter Aortic Valve Replacement August 17, 2016 April 30, 2021
NCT03107923 Completed Better Patient Selection to Transcatheter Aortic Valve Implantation April 26, 2017 March 31, 2021
NCT03112629 Completed Study to Improve Outcomes in Aortic Stenosis March 23, 2017 April 3, 2019
NCT00256165 Completed Phase 4 REST Study: Left Ventricular Regression European Study January 2006 July 2008
NCT03173534 Completed N/A WATCH-TAVR, WATCHMAN for Patients With Atrial Fibrillation Undergoing Transcatheter Aortic Valve Replacement December 15, 2017 December 6, 2022
NCT03181997 Completed Outcomes of Transcatheter Aortic Valve Implantation in Oncology Patients With Severe Aortic Stenosis January 1, 2017 March 1, 2019
NCT03186339 Completed Validation of the "TASQ" in Patients Undergoing SAVR or TF-TAVI September 8, 2017 January 13, 2020
NCT03192813 Completed Safety and Efficacy Comparison Of Two TAVI Systems in a Prospective Randomized Evaluation II April 20, 2017 June 4, 2020
NCT03196596 Completed Added Value of Patient-specific Computer Simulation in Transcatheter Aortic Valve Implantation (TAVI) May 23, 2017 January 31, 2019
NCT03243890 Completed N/A The Aortic Valve DECalcification (AVADEC) Trial January 12, 2018 May 1, 2021
NCT03248232 Completed Assessments of Thrombus Formation in TAVI August 1, 2017 June 30, 2018
NCT03270124 Completed N/A A pragmatiC sTrategy to Promote actIVity and Enhance Quality of Life AFTER Transcatheter Aortic Valve Replacement November 7, 2017 March 25, 2020
NCT03284827 Completed Phase 4 Anticoagulant Versus Dual Antiplatelet Therapy for Preventing Leaflet Thrombosis and Cerebral Embolization After Transcatheter Aortic Valve Replacement March 15, 2018 November 5, 2021
NCT04344353 Completed Analysis and Comparative Evaluation of Aortic Calcium by Computed Tomography and Histopathology in Patients With Aortic Stenosis January 1, 2020 January 1, 2021
NCT05714293 Enrolling by invitation N/A CT-evaluation of Coronary Ostia Height After Surgical Aortic Valve Replacement. January 11, 2023 January 10, 2025
NCT04372381 Enrolling by invitation N/A Supra-Annular vs. Annular ValvEs for Small Annuli May 12, 2020 June 2025
NCT05830760 Not yet recruiting N/A Expression of Sodium-glucose Co-transporter 2 in Human Heart June 2023 October 2025
NCT06420830 Not yet recruiting Valve Performance of the SAPIEN 3 Ultra RESILIA Valve: A Prospective Registry With Central Echocardiography Analysis. June 1, 2024 September 1, 2034
NCT05836311 Not yet recruiting Single Perclose Escalation Technique for Vascular Closure in TAVR July 19, 2023 February 19, 2025
NCT05861648 Not yet recruiting Phase 2 Folic Acid Supplementation in Calcific Aortic Valve Disease July 1, 2023 July 1, 2028
NCT06015997 Not yet recruiting Prevalence of ATTR Cardiac Amyloidosis in Patients Undergoing TAVR October 1, 2023 November 1, 2025
NCT04636073 Not yet recruiting N/A The Leaflex™ Early Feasibility Study December 2024 December 2025
NCT05536310 Not yet recruiting TAVIS Registry - Trilogy Heart Valve System for Management of Patients With Aortic Valve Disease March 2023 October 2027
NCT03575039 Not yet recruiting N/A VitaFlowTM II Transcatheter Aortic Valve System Study August 2018 December 2024
NCT05672836 Not yet recruiting Phase 4 ENAVOgliflozin Outcome Trial in Patients With Severe Aortic Stenosis After Transcatheter Aortic Valve Replacement December 2023 April 2026
NCT05875675 Not yet recruiting Phase 2 Effects of Pioglitazone in Calcific Aortic Valve Disease July 1, 2023 July 1, 2028
NCT06283940 Not yet recruiting N/A Exercise-based Cardiac Rehabilitation in Patients With Aortic Stenosis After Transcatheter Aortic Valve Implantation August 2024 January 2026
NCT05696145 Not yet recruiting Aortic Stenosis Associated Left Ventricular Remodeling - An Investigation of Genetic and Gender Specific Differences in 170 Patients Undergoing Aortic Valve Replacement Surgery March 1, 2023 January 31, 2025
NCT05895097 Not yet recruiting N/A Conventional Versus Left Bundle Branch Pacing in TAVI June 15, 2023 June 15, 2026
NCT06099665 Not yet recruiting N/A Addressing Undertreatment and Health Equity in Aortic Stenosis Using an Integrated EHR Platform April 2024 December 2024
NCT05721170 Not yet recruiting Phase 4 Impact of Beta Blockers on TAVI (BETA-TAVI) March 1, 2024 January 31, 2025
NCT05977257 Not yet recruiting VitaFlow® Transcatheter Aortic Valve Replacement System Pre-market Trial Long Term Follow Up (VITAL) July 30, 2023 October 30, 2028
NCT06269640 Not yet recruiting N/A NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Early Feasibility Study June 23, 2024 October 1, 2027
NCT06215378 Not yet recruiting Phase 3 Antagonization of Heparin With Protamine Sulfate After TAVI February 1, 2024 February 1, 2027
NCT05528211 Not yet recruiting Safety and Efficacy of Emergent TAVI in Patients With Severe AS September 1, 2022 November 1, 2028
NCT05991271 Not yet recruiting N/A Venus-Vitae Pivotal Study Smart-Align Study October 31, 2023 June 30, 2029
NCT06449469 Recruiting N/A The Nordic Aortic Valve Intervention Trial 4 (NOTION-4) May 1, 2021 January 1, 2029
NCT01737528 Recruiting STS/ACC Transcatheter Valve Therapy Registry (TVT Registry) June 2012 June 2035
NCT01805739 Recruiting Multi Modal Cardiac Imaging Prior Transcatheter Aortic Valve Implantation January 2013 December 2030
NCT02000115 Recruiting N/A Portico Re-sheathable Transcatheter Aortic Valve System US IDE Trial May 2014 July 2025
NCT02984449 Recruiting N/A Preventive Heart Rehabilitation to Prevent Complications in Patients Undergoing Elective Open Heart Surgery May 3, 2017 August 31, 2025
NCT03143361 Recruiting Prospective European Multicenter Study on Aortic Valve Replacement: (E-AVR Registry) November 1, 2017 October 2029
NCT03192774 Recruiting The Prospective Segeberg TAVI Registry September 2007 December 2032
NCT03298178 Recruiting ASAN Medical Center Aortic Valve Replacement Registry December 1, 2017 December 2031
NCT03303612 Recruiting N/A Clinical Monitoring Strategy Versus Electrophysiology-guided Algorithmic Approach With a New LBBB After TAVI October 15, 2017 December 2026
NCT03360591 Recruiting N/A Functional Assessment In TAVI: FAITAVI November 24, 2017 November 2024
NCT03453567 Recruiting Evaluation of Effectiveness and Safety of Aortic Valve Replacement in Routine Clinical Practice May 10, 2018 December 15, 2030
NCT03470246 Recruiting N/A Personalized Activity Intervention in Rehabilitation After Cardiac Operations (the PACO Trial) April 6, 2018 March 1, 2028
NCT03728049 Recruiting N/A Von Willebrand Factor Point-of-care Testing to Improve Minimally Invasive TAVI Outcomes December 18, 2019 December 2025
NCT03972644 Recruiting N/A Danish National Randomized Study on Early Aortic Valve Replacement in Patients With Asymptomatic Severe Aortic Stenosis January 1, 2020 September 1, 2029
NCT04171726 Recruiting Phase 3 Rotterdam EDOXaban Leaflet Evaluation in Patients After Transcatheter Aortic Valve Implantation August 1, 2019 September 1, 2023
NCT04227002 Recruiting Hamburg AoRtic Valve cOhoRt September 1, 2019 September 1, 2049
NCT04231461 Recruiting Quality of Life After Cardiac Surgery July 19, 2019 April 30, 2024
NCT04275726 Recruiting N/A LANDMARK Trial: a Randomised Controlled Trial of Myval THV November 4, 2020 December 31, 2033
NCT04312139 Recruiting Serum and Cellular Biomarkers for Aortic Valve Stenosis March 1, 2020 September 2025
NCT04358692 Recruiting N/A Measurement of Myocardial Stiffness Using Elastometry in Patients With Aortic Stenosis June 30, 2020 June 30, 2024
NCT04414865 Recruiting VitaFlow™ Transcatheter Aortic Valve System Post-market Study-The LAUNCH Study April 26, 2020 December 30, 2027
NCT04464655 Recruiting A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease December 12, 2019 January 31, 2025
NCT04473443 Recruiting Addition of Computer Simulations to Minimize Adverse Events After Transcatheter Aortic Valve Implantation August 1, 2020 June 30, 2023
NCT04533282 Recruiting Epitranscriptomic Blood Biomarkers for Coronary Artery Disease - A Prospective Cohort Study (IHD-EPITRAN) November 10, 2020 December 31, 2025
NCT04613193 Recruiting N/A Blood Pressure Reduction in Patients With Asymptomatic Aortic VALVE Stenosis March 1, 2019 June 1, 2031
NCT04703699 Recruiting Myval Global Study of Myval™ THV Series Implanted in Patients With Native Severe Aortic Valve Stenosis. August 7, 2020 November 30, 2028
NCT04827238 Recruiting Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE TAVR) August 30, 2021 December 31, 2023
NCT04882488 Recruiting Correlation of FFR and iFR With Cardiac PET Perfusion in Patients With Severe Aortic Valve Stenosis June 1, 2021 June 30, 2024
NCT04889872 Recruiting N/A PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR October 12, 2021 June 2037
NCT04893603 Recruiting N/A To Evaluate Safety and Effectiveness of Transcatheter Aortic Valve System in Patients With Severe Aortic Stenosis December 16, 2020 December 31, 2026
NCT05010980 Recruiting Early Detection of Cardiac Amyloidosis August 1, 2021 September 2023
NCT05015452 Recruiting The Leipzig TAVI Registry March 1, 2020 December 31, 2030
NCT05036018 Recruiting N/A RanDOmized stUdy Comparing Both Latest Generation Self-Expanding Valves and a Minimalist approaCH vs. Standard Of Care In transCathEter Aortic Valve Implantation August 30, 2021 October 31, 2033
NCT05078619 Recruiting N/A Percutaneous Coronary Intervention Before Transcatheter Aortic Valve Implantation October 5, 2021 August 22, 2028
NCT05146037 Recruiting N/A INTERvention With Cerebral Embolic Protection in Transcatheter Aortic Valve Implantation (INTERCEPTavi) September 1, 2021 December 2023
NCT05162742 Recruiting Phase 3 Colchicine and Inflammation in Aortic Stenosis December 22, 2022 December 22, 2025
NCT05172973 Recruiting N/A ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves November 22, 2023 February 2034
NCT05189886 Recruiting Transcatheter Aortic Valve Replacement (TAVR) Double Balloon Valvuloplasty November 10, 2021 December 2024
NCT05237804 Recruiting N/A Evaluation of an Intervention to Reduce the Time to Treatment for TAVI Patients October 26, 2022 December 31, 2024
NCT05278585 Recruiting Pacing the Atrium to Confirm or Exclude Pacemaker Indication in TAVI September 1, 2022 June 2024
NCT05283356 Recruiting Phase 4 Single Antiplatelet Treatment With Ticagrelor or Aspirin After Transcatheter Aortic Valve Implantation January 21, 2022 June 30, 2025
NCT05295628 Recruiting N/A Evaluation of Safety and Effectiveness of the EMBLOK EPS During TAVR October 17, 2023 February 1, 2025
NCT05386173 Recruiting Effect of Fetal Aortic Valvuloplasty on Outcomes January 1, 2021 December 31, 2029
NCT05404100 Recruiting Effects of Aortic Valve Replacement on Myocardial T1 Values in Severe Aortic Valve Stenosis April 1, 2021 April 1, 2024
NCT05454150 Recruiting N/A Balloon-Expandable Versus Self-expanding Transcatheter Heart Valve for Treatment of Symptomatic Native Aortic Valve Stenosis (BEST) April 19, 2023 July 19, 2025
NCT05459233 Recruiting N/A Valve Hemodynamic Optimization Based on Doppler-Echocardiography vs Catheterization Measurements Following ViV TAVR January 11, 2023 September 1, 2029
NCT05479188 Recruiting N/A Comparative Analysis of the Microcirculation During Cardiac Surgery With Minimal Invasive Versus Conventional Extracorporeal Circulation December 1, 2021 December 31, 2023
NCT05481008 Recruiting Cardiac Output, Cerebral Perfusion and Cognition in Patients Undergoing TAVI August 28, 2020 August 2023
NCT05487612 Recruiting N/A MiECC Versus Conventional Cardiopulmonary Bypass in Cardiac Surgery (MiECS) May 26, 2022 March 31, 2026
NCT05491070 Recruiting N/A Comparison of Different Vascular Closure Device in TAVI March 20, 2018 June 30, 2023
NCT05541679 Recruiting N/A Comparison of Left Bundle Branch Area Versus Right Ventricular Septal Pacing in Patients With High-degree Conduction Disease After Transcatheter Aortic Valve Replacement (Left Bundle BRAVE) December 28, 2022 December 31, 2025
NCT05550896 Recruiting Platelet Adhesion in the Pathobiology of Aortic Stenosis January 3, 2023 June 1, 2028
NCT05567809 Recruiting Defining Exercise Hemodynamics and Function After Transcatheter Aortic Valve Replacement (DEFINE-TAVR) Study. October 25, 2022 October 2024
NCT05572710 Recruiting Avalus European Registry - an Observational Study to Evaluate Safety and Efficacy in a Real World Population June 10, 2020 December 31, 2025
NCT05601453 Recruiting The ReTAVI Prospective Observational Registry September 5, 2023 December 2026
NCT05603026 Recruiting N/A MRI in Transcatheter Aortic Valve Replacement Patients November 21, 2023 December 30, 2024
NCT05641064 Recruiting Phase 3 Evaluation of Intraoperative Dexmedetomidine Use in Patients Undergoing Surgical Aortic Valve Replacement November 22, 2022 December 31, 2025
NCT05670041 Recruiting N/A Re-hospitalisation After Transcatheter Aortic Valve Implantation January 16, 2023 March 16, 2025
NCT05708118 Recruiting Progression of Ascending Aorta Diameters in Bicuspid Aortic Valve After Transcatheter or Surgical Replacement. January 20, 2023 January 21, 2024
NCT05709652 Recruiting N/A Impact of Fast-rotation Coronary CT in Patients Undergoing Aortic Stenosis Workup February 27, 2024 June 3, 2026
NCT05711186 Recruiting N/A Structured Shared Decision Making for Patients Undergoing SAVR or TAVR April 17, 2023 May 30, 2026
NCT05758662 Recruiting The Effect of Subclinical Leaflet Thrombosis and Prosthesis Type on Transcatheter Aortic Valve Degeneration (POPular PET TAVI) November 16, 2023 November 2025
NCT05758909 Recruiting Evaluation of the Viability and Safety of Early Discharge Protocol After TAVI Implantation April 4, 2023 December 1, 2025
NCT05774691 Recruiting Phase 4 Routine Versus Selective Protamine Administration to Reduce Bleeding Complications After Transcatheter Aortic Valve Implantation (POPular ACE TAVI) November 1, 2023 December 31, 2025
NCT05778773 Recruiting OUTcomes Evaluation of Current Therapeutic STrategies for Severe Aortic Valve steNosis anD the agING Population in ITALY November 1, 2018 November 2029
NCT05779787 Recruiting COronary Re-engageMent aFter randOm NavitoR alignmenT (COMFORT STUDY) February 15, 2023 May 15, 2027
NCT05788770 Recruiting N/A Preoperative CT-imaging With Patient-specific Computer Simulation in Transcatheter Aortic Valve Replacement: a Randomized Controlled Trial April 6, 2022 December 31, 2024
NCT05862558 Recruiting Intravascular Lithotripsy in High Risk Calcified Iliac Anatomy for Transfemoral TAVR March 30, 2023 December 2025
NCT05864456 Recruiting N/A Prizvalve Pro™ Transcatheter Aortic Valve Replacement Study July 5, 2023 May 2028
NCT05864625 Recruiting N/A Comparison of Hemodynamic Stability During Anesthesia Using Remimazolam and Sevoflurane in Minimally Invasive AVR June 29, 2023 June 30, 2024
NCT05892588 Recruiting Prevalence Study of Cardiovascular Diseases in a Population ≥ 65 Years in Italy June 1, 2022 July 1, 2023
NCT05902897 Recruiting Aortic or Mitral Valve Replacement With the Braile Biomédica® Bovine Pericardium Valvular Bioprosthesis January 1, 2023 October 30, 2023
NCT05909748 Recruiting N/A FIH Study of the GEMINUS TAVI System in Patients With Severe Symptomatic Aortic Stenosis May 21, 2023 April 2030
NCT05930899 Recruiting Translational-Omics in Aortic Stenosis (TOmAS) Biobank October 12, 2017 January 1, 2040
NCT05932615 Recruiting N/A ENVISION IDE Trial: Safety and Effectiveness of NAVITOR in Transcatheter Aortic Valve Implantation March 19, 2024 April 2036
NCT05956652 Recruiting Hydra Registry - Italy Experience July 1, 2023 July 31, 2029
NCT06000943 Recruiting Ischemic And Bleeding Risk Assessment After TAVR August 1, 2023 December 15, 2024
NCT06040398 Recruiting The JUMPSTART Program: Encouraging Early Mobilization and Optimizing Recovery of TAVR Patients' Post-hospital Discharge March 1, 2023 March 31, 2024
NCT06049654 Recruiting N/A Comparison of Allegra vs Sapien Transcatheter Aortic Valves in Valve-In-Valve Indication February 1, 2024 November 1, 2025
NCT06103591 Recruiting N/A Controlled Arterial Protection to Ultimately Remove Embolic Material December 27, 2023 March 2024
NCT06154642 Recruiting Perioperative Hemodynamic and Microcirculatory Physiological Study During TAVI May 8, 2024 July 31, 2024
NCT06171802 Recruiting Phase 4 EMPagliflozin After Aortic Valve Replacement February 14, 2024 January 2026
NCT06235385 Recruiting European Association of Cardiovascular Imaging Multiple and Mixed Valvular Disease Study February 7, 2024 August 1, 2029
NCT06342635 Recruiting Hydra Single-centre Experience - Copenhagen, Denmark June 18, 2024 October 31, 2026
NCT06404437 Recruiting Detection of Aortic Stenosis With Smartphone Auscultation Using Machine Learning (HEARTBEAT-Pilot) March 9, 2023 October 1, 2024
NCT02361996 Suspended Quantitative Measurement of Myocardial Perfusion by Cardiac CT in Patients February 2015 April 2022
NCT03843320 Suspended Impact of SAVR and TAVR on Patient's Activity and Mobility December 2021 December 2024
NCT04142658 Terminated Phase 3 PROACT Xa - A Trial to Determine if Participants With an On-X Aortic Valve Can be Maintained Safely on Apixaban May 1, 2020 December 12, 2022
NCT03805711 Terminated N/A HLT Meridian Valve CE Mark Trial July 12, 2019 September 20, 2019
NCT00590135 Terminated Phase 4 The Effect of Lipitor on Aortic Stenosis August 2000 April 26, 2010
NCT03667365 Terminated N/A Randomized Study for the Optimal Treatment of Symptomatic Patients With Low Gradient Severe Aortic Valve Stenosis and Preserved Left Ventricular Ejection Fraction March 19, 2019 November 16, 2021
NCT02766075 Terminated N/A A STEP for Patients Prior to Undergoing TAVR: A Pilot Study May 2016 February 2018
NCT00986193 Terminated N/A Transapical Transcatheter Treatment Versus Conventional Surgery in Patients With Native Aortic Valve Stenosis December 2008 April 2016
NCT00269165 Terminated Phase 3 Adjuvant Radiation in Aortic Valvuloplasty - ARAVA November 2005
NCT01504737 Terminated N/A Rehabilitation in Aortic Stenosis Patients September 2011 September 1, 2017
NCT04639258 Terminated N/A Medtronic Evolut™ EXPAND TAVR I Feasibility Study May 28, 2021 June 7, 2022
NCT02799823 Terminated N/A Transfemoral Replacement of Aortic Valve With HLT MeriDIAN Valve Early Feasibility Trial April 27, 2017 January 20, 2023
NCT01810679 Terminated N/A Perceval S Aortic Heart Valve Study- North America April 2013 April 2018
NCT03308435 Terminated Effect of TF-TAVR on Emotional Status, Quality of Life, Frailty and Inflammation November 6, 2017 December 31, 2020
NCT01939678 Terminated Characterization and Role of Mutations in Sodium-phosphate Cotransporters in Patients With Calcific Aortic Valve Disease September 2013 September 2019
NCT02818959 Terminated N/A First in Man Study of the JenaValve TAVI Plus System Transfemoral December 2013 May 2015
NCT01636648 Terminated Enable I Long-term Follow-up Study August 2012 April 2016
NCT04008550 Terminated N/A Prognostic Impact of the Evolution of PAH 3 Months After TAVI (HTP-TAVI) March 6, 2019 March 5, 2020
NCT04009720 Terminated RESPOND EDGE Post Market Study October 11, 2019 June 2, 2021
NCT00404287 Terminated Phase 4 Randomized Study to Evaluate the Efficacy of Fluvastatin on Inflammatory Markers in Patients With Aortic Stenosis. October 1, 2006 January 2018
NCT03618095 Terminated N/A REPRISE IV: LOTUS Edge Valve System in Intermediate Surgical Risk Subjects January 14, 2019 March 31, 2021
NCT02007967 Terminated Non-Contrast Magnetic Resonance Angiography Assessment of Patients Referred for Transcatheter Aortic Valve Implantation December 2013 January 2014
NCT02854319 Terminated N/A REpositionable Percutaneous Replacement of NatIve StEnotic Aortic Valve Through Implantation of LOTUS EDGE Valve System September 7, 2016 March 13, 2018
NCT00598598 Terminated Echocardiographic Assessment of Cardiovascular Changes in Long Term Space Flight October 2003 July 2008
NCT00538759 Terminated Phase 2/Phase 3 Radiation Following Percutaneous Balloon Aortic Valvuloplasty to Prevent Restenosis September 2007 July 2010
NCT03810820 Unknown status N/A Remote ECG Monitoring of TAVI Patients June 20, 2018 July 30, 2021
NCT03881527 Unknown status N/A Nitinol Circular Blade October 2015 December 2019
NCT03665389 Unknown status N/A Evaluation of Fractional Flow Reserve Calculated by Computed Tomography Coronary Angiography in Patients Undergoing TAVR September 13, 2018 March 31, 2022
NCT03649594 Unknown status Risk Stratification Post TAVI Using TEG October 1, 2020 April 30, 2023
NCT03633383 Unknown status Outcomes of Transcatheter Aortic Valve Implantation in Management of Severe Symptomatic Aortic Stenosis August 31, 2018 January 2021
NCT00699452 Unknown status Phase 3 The Potential of Candesartan to Retard the Progression of Aortic Stenosis May 2009 December 2014
NCT03621709 Unknown status CoreValve™ Evolut R™ 34 mm System Registry (CoreValve34) August 1, 2017 September 2020
NCT04056832 Unknown status N/A Left Ventricular Reverse Remodeling In Aortic Valve Replacement With Single Strip Pericardium Versus Mechanical Valve April 20, 2017 April 20, 2020
NCT03600935 Unknown status N/A Safety and Feasibility of Early Discharge for Transfemoral Transcatheter Aortic Valve Replacement October 2018 September 2021
NCT03574311 Unknown status Phase 4 Preoperative Intravenous Ferric Carboxymaltose and Placebo in the Treatment of Patients Undergoing Cardiac Surgery October 2, 2018 December 2023
NCT03549559 Unknown status N/A Imaging Histone Deacetylase in the Heart September 7, 2018 July 1, 2023
NCT03385785 Unknown status Ventriculo-arterial Coupling Modification Evaluated by PRAM During TAVI Procedure September 14, 2017 November 1, 2018
NCT00294775 Unknown status Phase 3 Effect of Angiotensin II Receptor Blockers (ARB) on Left Ventricular Reverse Remodelling After Aortic Valve Replacement in Severe Valvular Aortic Stenosis February 2006 June 2009
NCT03361046 Unknown status Polish Transcatheter Aortic Valve-in-Valve Implantation (ViV-TAVI) Registry January 1, 2018 May 30, 2024
NCT03361007 Unknown status Polish Registry of Common Carotid Artery Access for TAVI January 1, 2018 May 30, 2024
NCT04307888 Unknown status Spanish Percutaneous Aortic INtervention REGISTRY (SPAIN REGISTRY) April 2020 March 2022
NCT00222950 Unknown status Concentration of Plant Sterols in Serum and Aortic Valve Cusps September 2003 September 2005
NCT04335149 Unknown status Follow-up After TAVR Without Systematic Intensive Care Unit Admission January 1, 2017 December 1, 2022
NCT03051360 Unknown status Phase 2 PCSK9 Inhibitors in the Progression of Aortic Stenosis June 1, 2017 January 1, 2020
NCT03051334 Unknown status Ascending Aortic Dilation in BiAV After TAVR January 1, 2007 December 30, 2017
NCT04392492 Unknown status Vascular Closure Device in Transcatheter Aortic Valve Replacement January 25, 2017 January 31, 2021
NCT03001960 Unknown status Phase 3 Dual AntiPlatelet Therapies for Prevention of Periinterventional Embolic Events in TAVI March 2017 April 2018
NCT01932099 Unknown status Phase 2 TranScatheter Aortic Valve RepLacement System US Feasibility Trial August 2013 December 2018
NCT04429035 Unknown status N/A SLOW-Slower Progress of caLcificatiOn With Vitamin K2 September 23, 2019 December 23, 2023
NCT02917525 Unknown status Phase 2 Bicuspid Aortic Valve Stenosis and the Effect of vItamin K2 on Calciummetabolism on 18F-NaF PET/MRI August 2016 December 2019
NCT02019797 Unknown status Phase 4 Desflurane-induced Myocardial Protection January 2014 December 2016
NCT02444104 Unknown status Non-invasive Blood Pressure and Cardiac Output Measurement by Using Applanation Tonometry June 2015 December 2016
NCT01822964 Unknown status N/A Oxygenation of the Cerebrum and Cooling During Transcatheter Aortic Valve Implantation (TAVI) Procedures - Part II March 2013 December 2014
NCT05015829 Unknown status Diagnostic Impact of Low-dose Dobutamine Echocardiography in Low-flow Low-gradient Aortic Stenosis September 1, 2019 August 31, 2022
NCT02288871 Unknown status N/A Pilot Trial: Comparison of Flow Patterns October 2014 December 2021
NCT05065697 Unknown status Brain Lesions After Transcatheter Aortic Valve Replacement January 2022 January 2024
NCT01707927 Unknown status Comparison of Two Biological Aortic Valves. Mosaic Ultra and Trifecta. September 2012 December 2022
NCT02221921 Unknown status N/A Safety and Efficacy Study of MicroPort's Transcatheter Aortic Valve and Delivery System for TAVI September 2014 September 2021
NCT00767013 Unknown status N/A Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease May 2007
NCT01683474 Unknown status N/A Safety and Performance of TAVI of Venus MedTech Aortic Valve Prosthesis September 2012 April 2016
NCT02195102 Unknown status The Asian Pacific TAVR Multicenter Registry December 2014 December 2021
NCT01679431 Unknown status Metabolic Determinants of the Progression of Aortic Stenosis April 2005 January 2024
NCT05235529 Unknown status Neuropsychological and Neuroimaging Evaluation of the Cognitive Impairment in Aortic Valve Replacement (ARTiCO) January 4, 2021 December 2023
NCT02163850 Unknown status N/A Transcatheter Aortic Valve Replacement System Pivotal Trial June 2015 December 2021
NCT02080299 Unknown status Phase 2 Protection by Remote Ischemic Preconditioning During Transcatheter Aortic Valve Implantation September 2013 August 2017
NCT05256758 Unknown status N/A Oxford - Fibrates in Aortic Stenosis May 29, 2019 March 31, 2022
NCT05272020 Unknown status N/A Outcome, Recuperation and Hemodynamics in Aortic Stenosis March 22, 2021 March 31, 2024
NCT00710775 Unknown status N/A Heart Leaflet Technologies Valve Study November 2007 December 2008
NCT00176410 Unknown status Phase 2 Statin Therapy in Asymptomatic Aortic Stenosis January 2003 December 2009
NCT05308888 Unknown status Phase 2 Impact of Local Tissue Inflammation on Intramyocardial Conduction Pathways Post Percutaneous Valve : Evaluation by Positron Emission Tomography on Exploratory Cohort May 1, 2022 May 1, 2024
NCT05374733 Unknown status N/A Coronary Physiology Peri-Transcatheter Left-sided Valvular Interventions March 22, 2021 March 1, 2023
NCT01475799 Unknown status N/A Percutaneous Aortic Valve 18F System for the Treatment of Patients With Severe Aortic Stenosis November 2011 July 2019
NCT01201070 Unknown status Phase 4 Study of Administration Of Antithrombin in Patients With Low Plasmatic Levels of Antithrombin After Cardiac Surgery September 2009 November 2011
NCT05422170 Unknown status HEParin Antagonisation in Transcatheter Aortic Valve Implantation July 1, 2022 April 1, 2023
NCT01165827 Unknown status German Aortic Valve Registry July 2010 December 2022
NCT02623907 Unknown status China Valve Registry Study-1 May 2016 May 2020
NCT04717219 Unknown status Myeloid Cells in Aortic Valve Stenosis November 19, 2020 December 31, 2022
NCT02608567 Unknown status Prognostic Impact of Myocardial Longitudinal Strain in Asymptomatic Aortic Stenosis: a Meta-Analysis October 2015 December 2017
NCT02541877 Unknown status Phase 3 Sizing-sTrategy of Bicuspid AoRtic Valve Stenosis With Transcatheter Self-expandable Valve September 2015 September 2023
NCT00811330 Unknown status Phase 3 Effects of High Dose Atorvastatin in Patients With Surgical Aortic Stenosis December 2008 January 2018
NCT02536703 Unknown status Phase 3 Safety and Efficacy of Lotus Valve For TAVI In Patients With Severe Aortic Stenosis In Chinese Population September 2015 December 2020
NCT02498639 Unknown status Phase 4 The Pacing vs No Pacing Study - PNP Study April 2015 January 2016
NCT02468219 Unknown status N/A Cardiovascular Rehabilitation in Patients With Severe Aortic Stenosis Submitted to Valvar Correction August 2020 July 2022
NCT01835028 Unknown status Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis (TOPAS Study) June 2002 January 2024
NCT01845285 Unknown status A Registry to Evaluate the Direct Flow Medical Transcatheter Aortic Valve System March 2013 December 2019
NCT04525937 Unknown status Racial and Economic Disparities and Unmet Needs in Patients With Severe Aortic Valvular Disease June 4, 2018 August 1, 2022
NCT00647088 Unknown status Genetic of Aortic Valve Stenosis - Clinical and Therapeutic Implications March 2008 December 2017
NCT04573049 Unknown status Phase 4 The Effectiveness and Safety of Levosimendan in Patients With Severe Aortic Stenosis and Heart Failure Undergoing Transcatheter Aortic Valve Replacement September 1, 2020 December 30, 2022
NCT04600739 Unknown status Validation of a Novel, Non-Dimensional Approach for Estimation of Pressure Gradients in Aortic Stenosis October 28, 2019 June 30, 2021
NCT01118442 Unknown status Determination of the Acute Effects of Aortic Stenosis on Coronary Artery Haemodynamics December 2009 December 2019
NCT04632095 Unknown status N/A Parasternal vs. Sternotomy Approach for Conventional Aortic Valve Replacement March 16, 2021 November 15, 2022
NCT02713932 Unknown status The Italian Society of Invasive Cardiology Registry on Percutaneous Aortic Valve July 2010
NCT02711540 Unknown status Retrospective Analysis of Procedural Aspects of Transcatheter Aortic Valve Implantation (TAVI) on Peri-procedural Stroke February 2016 July 2016
NCT02650388 Unknown status Phase 4 Frailty and Cognitive Function Assessment of TAVI Patients November 2015 October 2018
NCT04655742 Unknown status N/A VitaFlow™ Transcatheter Aortic Valve System Pre-market Trial June 27, 2014 December 31, 2021
NCT02627391 Unknown status N/A Early Surgery for Patients With Asymptomatic Aortic Stenosis January 2016 November 2019
NCT04694859 Unknown status Romanian National Registry of Outcomes After Transcatheter Aortic Valve Implantation in Patients With Severe Aortic Stenosis - RO-TAVI January 5, 2021 July 30, 2023
NCT01905852 Withdrawn Use of Cardiac-MRI to Predict Results for People With Severe Aortic Stenosis June 27, 2013 December 31, 2016
NCT05481814 Withdrawn CPX in Paradoxical Low Flow Aortic Stenosis September 30, 2017 July 1, 2022
NCT02855099 Withdrawn N/A Can Rehabilitation After TAVI Precipitate Recovery and Improve Prognosis August 1, 2016 July 24, 2017
NCT02964962 Withdrawn N/A REPRISE EDGE 29 mm EU Study April 1, 2018 December 30, 2018
NCT00598754 Withdrawn Diagnostic Three Dimensional Echocardiography Study Protocol June 2001 July 2008
NCT02838199 Withdrawn Phase 4 TRANscatheter or SurgIcal Aortic Valve ReplacemenT in All-Comers With Severe Aortic Valve Stenosis December 2016 December 2030
NCT03928639 Withdrawn Structural Heart and Valve Network PROSPECTIVE Registry January 10, 2023 January 10, 2023
NCT04363294 Withdrawn N/A Targeted Testing for ATTR Among Aortic Stenosis Patients-Pilot March 2022 August 2023
NCT03315832 Withdrawn Phase 2/Phase 3 Efficacy of Angiotensin Receptor Blocker Following aortIc Valve Intervention for Aortic STenOsis: a Randomized mulTi-cEntric Double-blind Phase II Study January 2, 2023 July 2, 2025
Disase is a (Disease Ontology)
DOID:62
Cross Reference ID (Disease Ontology)
GARD:5830
Cross Reference ID (Disease Ontology)
ICD10CM:I06.0
Cross Reference ID (Disease Ontology)
ICD10CM:Q23.0
Cross Reference ID (Disease Ontology)
ICD9CM:395.0
Cross Reference ID (Disease Ontology)
ICD9CM:746.3
Cross Reference ID (Disease Ontology)
MESH:D001024
Cross Reference ID (Disease Ontology)
NCI:C50462
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:155282009
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:18546004
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:60573004
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0003507
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0152417
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0155567
Exact Synonym (Disease Ontology)
Aortic stenosis
Exact Synonym (Disease Ontology)
Rheumatic aortic stenosis
Exact Synonym (Disease Ontology)
rheumatic aortic valve stenosis
HPO alt_id (Human Phenotype Ontology)
HP:0005140
HPO Human Phenotype ID (Human Phenotype Ontology)
HP:0001650
MeSH unique ID (MeSH (Medical Subject Headings))
D001024