aortic valve stenosis
Information
- Disease name
- aortic valve stenosis
- Disease ID
- DOID:1712
- Description
- "An aortic valve disease that is characterized by narrowing of the heart's aortic valve opening." [url:http\://en.wikipedia.org/wiki/Aortic_valve_stenosis, url:https\://rarediseases.info.nih.gov/diseases/5830/aortic-valve-stenosis]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes | Mutation | Description | Source | Links |
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NCT ID | Status | Phase | Summary | Start date | Completion date |
---|---|---|---|---|---|
NCT04722250 | Active, not recruiting | N/A | SMall Annuli Randomized To Evolut™ or SAPIEN™ Trial | April 2, 2021 | December 2027 |
NCT06192706 | Active, not recruiting | N/A | Clinical Investigation for the Foldax Tria Aortic Heart Valve- India | January 1, 2022 | September 1, 2024 |
NCT04665596 | Active, not recruiting | N/A | Valvosoft First-In-Human Study in Severe Symptomatic Aortic Stenosis | December 23, 2019 | May 15, 2024 |
NCT04655248 | Active, not recruiting | ACURATE neo2™ Post Market Clinical Follow up Study | December 16, 2020 | December 31, 2026 | |
NCT02661451 | Active, not recruiting | N/A | Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD) | September 2016 | February 2025 |
NCT03411304 | Active, not recruiting | Aortic Stenosis: Determinants and Prognostic Value of Preoperative Left Ventricular Remodeling After Valvular Replacement | December 5, 2017 | June 2025 | |
NCT02701283 | Active, not recruiting | N/A | Medtronic Evolut Transcatheter Aortic Valve Replacement in Low Risk Patients | March 2016 | March 2026 |
NCT04649099 | Active, not recruiting | N/A | The Leaflex™ Standalone Study Protocol | September 2, 2020 | December 2024 |
NCT03112980 | Active, not recruiting | N/A | Randomized Trial of TAVI vs. SAVR in Patients With Severe Aortic Valve Stenosis at Low to Intermediate Risk of Mortality | May 10, 2017 | January 2028 |
NCT05052684 | Active, not recruiting | N/A | The Leaflex™ Brazilian Standalone Study | October 3, 2022 | December 31, 2024 |
NCT03699345 | Active, not recruiting | CENTERA PMCF: Post-Market Follow-up of the CENTERA Transcatheter Heart Valve System | January 7, 2019 | September 2024 | |
NCT03517436 | Active, not recruiting | N/A | ExCEED: CENTERA THV System in Intermediate Risk Patients Who Have Symptomatic, Severe, Calcific, Aortic Stenosis | September 18, 2018 | July 2030 |
NCT02732691 | Active, not recruiting | N/A | JENAVALVE AS EFS TRIAL: Pericardial TAVR Aortic Stenosis Study | October 21, 2016 | April 2024 |
NCT03444259 | Active, not recruiting | Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients | February 1, 2016 | December 31, 2029 | |
NCT03481387 | Active, not recruiting | N/A | PERCEVAL S Valve Clinical Study for Chinese Registration | January 26, 2018 | February 25, 2024 |
NCT03851068 | Active, not recruiting | N/A | Early Feasibility Study for the Foldax Tria Aortic Heart Valve | June 18, 2019 | December 2026 |
NCT04160130 | Active, not recruiting | N/A | RHEIA (Randomized researcH in womEn All Comers With Aortic Stenosis) | November 29, 2019 | June 2024 |
NCT05024279 | Active, not recruiting | N/A | Left Bundle Branch Area Pacing in Patients After TAVR | August 6, 2021 | April 2025 |
NCT04281771 | Active, not recruiting | N/A | Assessment of Paravalvular Leak After TAVI by Hemodynamic Measurements and Cardiac MRI | September 17, 2019 | October 28, 2026 |
NCT04555967 | Active, not recruiting | SAPIEN 3 Ultra System PMCF | June 30, 2020 | November 2026 | |
NCT03666741 | Active, not recruiting | Inspiris Resilia Durability Registry | April 26, 2019 | May 2025 | |
NCT05531578 | Active, not recruiting | N/A | Transfemoral Implant of Inovare® Transcatheter Valve | September 11, 2020 | December 30, 2028 |
NCT03305094 | Active, not recruiting | N/A | The Effect of Remote Ischemic Preconditioning in Aortic Valve Replacement Surgery | April 11, 2014 | December 1, 2024 |
NCT02426307 | Active, not recruiting | Subclinical Aortic Valve Bioprosthesis Thrombosis Assessed With 4D CT | April 2015 | April 2030 | |
NCT02825134 | Active, not recruiting | N/A | Comparison of TAVR With SAVR in Younger Low Surgical Risk Patients With Severe Aortic Stenosis | June 30, 2016 | June 2029 |
NCT02434263 | Active, not recruiting | N/A | A Clinical Evaluation of the HYDRA Self Expanding Transcatheter Aortic Valve | August 13, 2015 | July 2025 |
NCT05235568 | Active, not recruiting | N/A | VALVOSOFT® Pivotal Study | June 15, 2022 | August 15, 2024 |
NCT03471065 | Active, not recruiting | N/A | The SAPIEN 3 Ultra System in Intermediate Risk Patients With Symptomatic, Severe Aortic Stenosis | June 1, 2018 | February 2025 |
NCT04869631 | Active, not recruiting | Screening for Amyloidosis Before Aortic Valve Elective Replacement | February 1, 2021 | March 31, 2028 | |
NCT04514250 | Active, not recruiting | Stress Aortic Valve Index for Assessing Risk in Aortic Valve Stenosis Patients | April 14, 2021 | October 1, 2028 | |
NCT05171712 | Active, not recruiting | N/A | Portico and Navitor India Clinical Trial | May 6, 2022 | June 2025 |
NCT03910751 | Active, not recruiting | POLESTAR Trial - An International Multi-center Early Discharge TAVI Program | April 1, 2019 | February 1, 2024 | |
NCT04860752 | Active, not recruiting | SAPIEN 3 Ultra EU PMS | April 20, 2021 | July 2024 | |
NCT03411317 | Active, not recruiting | Aortic Stenosis: Determinants of Progression, Severity and Left Ventricular Remodeling | December 11, 2017 | December 2025 | |
NCT04836897 | Active, not recruiting | N/A | PrizValve® Transcatheter Aortic Valve Replacement Study | January 19, 2021 | June 2028 |
NCT03094143 | Active, not recruiting | N/A | Early Valve Replacement Guided by Biomarkers of LV Decompensation in Asymptomatic Patients With Severe AS | July 21, 2017 | June 30, 2032 |
NCT03561805 | Active, not recruiting | N/A | Prolonged Continuous ECG Monitoring Prior to Transcatheter Aortic Valve Implantation | June 1, 2017 | June 1, 2026 |
NCT03863132 | Active, not recruiting | N/A | accuRate Evaluation of Benefit With Optimal Medical Treatment With or Without Transcatheter Valve Repair of PARADOXical Low Flow Low Gradient Aortic Stenosis | July 3, 2019 | March 1, 2028 |
NCT03520101 | Active, not recruiting | N/A | Comparison of the Balloon-Expandable Edwards Valve and Self-Expandable CoreValve Evolut R or Evolut PRO System for the Treatment of Small, Severely Dysfunctional Surgical Aortic Bioprotheses. The 'LYTEN' Trial | May 10, 2017 | May 31, 2024 |
NCT02260466 | Active, not recruiting | N/A | Prevalence and Post-surgical Outcomes of CARdiac Wild-type TransthyrEtin amyloidoSIs in Elderly Patients With Aortic steNosis Referred for Valvular Replacement. | October 2014 | December 31, 2024 |
NCT03058627 | Active, not recruiting | N/A | Revascularization in Patients Undergoing Transcatheter Aortic Valve Implantation | September 15, 2017 | November 15, 2027 |
NCT03876964 | Available | J-Valve Compassionate Use | |||
NCT01720342 | Completed | Enable® Aortic Sutureless Bioprosthesis Evaluation | February 2013 | April 2018 | |
NCT01721642 | Completed | Phase 1/Phase 2 | A Pilot Study to Evaluate the Safety and Efficacy of the Apica Access, Stabilization and Closure (ASC™) Device | May 2012 | March 2013 |
NCT00005199 | Completed | Balloon Valvuloplasty Registry | June 1987 | November 1994 | |
NCT01789567 | Completed | N/A | Engager Direct Aortic Clinical Study | May 2013 | June 2015 |
NCT01802788 | Completed | 5 Year Observation of Patients With PORTICO Valves | April 16, 2013 | October 19, 2022 | |
NCT00081666 | Completed | Logical Analysis of Data and Cardiac Surgery Risk | July 2004 | June 2007 | |
NCT05641584 | Completed | Is Monocyte/HDL Ratio a Predictor of Mortality in Aortic Valve Surgery | May 10, 2022 | July 10, 2022 | |
NCT05603429 | Completed | Investigation of Myocardial Protection Level With Specific Cardioplegia Methods in Cardiac Surgery | October 13, 2022 | August 8, 2023 | |
NCT05580237 | Completed | Pressure Gradient vs. Flow Relationships in Patients With Symptomatic Valvular Aortic Stenosis | September 1, 2019 | December 1, 2023 | |
NCT01843426 | Completed | N/A | Aortic Stenosis Pre-Transcatheter Aortic Valve Replacement (TAVR) Procedure CT Scan | February 2013 | September 25, 2017 |
NCT01852552 | Completed | Costs, Cognitive Abilities and Quality of Life After Transcatheter Aortic Valve Implantation and Surgical Aortic Valve Replacement | December 2011 | January 2016 | |
NCT05503199 | Completed | N/A | Comparison of Strategies for Vascular Access Closure After Transcatheter Aortic Valve Implantation | October 1, 2022 | April 18, 2024 |
NCT01959503 | Completed | N/A | Progel Vascular Sealant | November 2013 | December 2014 |
NCT01972555 | Completed | N/A | Cardiac Function After Minimally Invasive Aortic Valve Implantation | October 2013 | July 2015 |
NCT01991444 | Completed | CGA-TAVI Registry to Evaluate the Predictive Value of a CGA in Predicting TAVI Outcomes | February 2014 | February 2017 | |
NCT00005190 | Completed | Reproduction and Survival After Cardiac Defect Repair | July 1986 | December 1998 | |
NCT05439395 | Completed | Study on the Clinical Performance of Steelex® Sternum Set for Sternal Closure | May 18, 2022 | April 7, 2023 | |
NCT05308173 | Completed | Aortic Valve replAcement in eLective Patients From aOrtic Valve multiceNter Registry | January 1, 2015 | June 30, 2021 | |
NCT02031302 | Completed | RESPOND Post Market Study | May 27, 2014 | May 18, 2021 | |
NCT02049203 | Completed | Phase 1 | Safety of Ataciguat in Patients With Moderate Calcific Aortic Valve Stenosis | January 2014 | March 2015 |
NCT02070731 | Completed | N/A | DEFLECT III: A Prospective, Randomized Evaluation of the TriGuard™ HDH Embolic Deflection Device During TAVI | February 2014 | April 2015 |
NCT02073851 | Completed | N/A | DEFLECT II: A Study to Evaluate the Safety and Performance of the TriGuard™HDH in Patients Undergoing TAVR | January 2014 | September 2014 |
NCT02073864 | Completed | A Study to Evaluate the Neuro-embolic Consequences of TAVR | November 2013 | August 2015 | |
NCT05241821 | Completed | Acute STROke Complicating TAVI - Management and Outcomes | June 1, 2021 | February 5, 2022 | |
NCT02099942 | Completed | Post-Market Surveillance Registry to Monitor Performance and Safety of V8 Device | March 2014 | December 2015 | |
NCT02127580 | Completed | Balloon Expandable Transcatheter Aortic Valve Implantation Without Predilation of the Aortic Valve | April 2014 | May 2016 | |
NCT02146755 | Completed | Improving Echo Measurements in the Diagnosis of Aortic Stenosis | August 2013 | December 2015 | |
NCT02149654 | Completed | Engager Align Post-market Clinical Study | May 2014 | January 2017 | |
NCT02157142 | Completed | N/A | HLT transfemOral Replacement of aortIc Valve Via transcatherteriZatiON | August 2014 | October 2019 |
NCT02162069 | Completed | N/A | Coronary and Structural Interventions - Transcatheter Aortic Valve Replacement | June 2014 | December 2018 |
NCT02193035 | Completed | N/A | Microparticles in Severe Aortic Stenosis | June 2014 | June 2015 |
NCT02209298 | Completed | CoreValve VIVA Study Evaluation of the Clinical Outcomes of CoreValve in Degenerative Surgical Aortic Bioprosthesis. | November 2014 | December 3, 2018 | |
NCT05082337 | Completed | N/A | The SAVVY Guidewire in Transcatheter Aortic Valve Replacement Procedures | October 8, 2021 | December 28, 2021 |
NCT02241109 | Completed | N/A | Predicting Aortic Stenosis Progression by Measuring Serum Calcification Propensity | September 30, 2014 | February 28, 2017 |
NCT02241447 | Completed | Quality of Care in AS IMPULSE Study | August 8, 2014 | May 31, 2018 | |
NCT02249000 | Completed | N/A | BIOVALVE - I / II Clincial Investigation | September 2014 | May 2023 |
NCT02272621 | Completed | N/A | Bleeding in Partial Upper Hemisternotomy Versus Full Sternotomy Aortic Valve Replacement | November 2013 | October 2020 |
NCT02280824 | Completed | Phase 1 | Transcaval Access for Transcatheter Aortic Valve Replacement in People With No Good Options for Aortic Access | October 30, 2014 | December 28, 2018 |
NCT02287662 | Completed | N/A | The Multidisciplinary, Multimodality, But Minimalist Approach to Transfemoral Transcatheter Aortic Valve Replacement | March 2015 | May 2018 |
NCT02289339 | Completed | Everyday Practice With Transcatheter Aortic Valve Implantation | November 2007 | May 20, 2018 | |
NCT02308150 | Completed | The Asian Transcatheter Aortic Valve Replacement Registry | December 2014 | September 24, 2019 | |
NCT02308566 | Completed | Phase 4 | Cerebral Embolic Load in Patients Undergoing Surgical Aortic Valve Replacement: A Comparison of the Conventional With the Minimized Extracorporeal Circulation Technique Using Transcranial Doppler Ultrasound | June 2011 | June 2016 |
NCT02316587 | Completed | Assessment of Myocardial Fibrosis in Aortic STenosis | March 2014 | December 2016 | |
NCT02324140 | Completed | Inflammatory Response in Aortic Valve Replacement | June 2012 | May 2015 | |
NCT02337140 | Completed | N/A | Indication of Permanent Cardiac Parcing After Tanscatheter Aortic Valve Implantation | August 2014 | August 2016 |
NCT02375282 | Completed | N/A | Physical and Functional Recovery From Cardiac Surgery in Hospitalized Patients: A Feasibility Pilot Study | March 2015 | July 2016 |
NCT02394184 | Completed | The Bicuspid Aortic Stenosis Following Transcatheter Aortic Valve Replacement Registry | May 2015 | September 24, 2019 | |
NCT02395107 | Completed | Left Atrial Volume Index in Asymptomatic Aortic Stenosis | January 2014 | June 2016 | |
NCT02408003 | Completed | N/A | Changes in Cardiac Deformation Following Physiologic Alterations and Inotropic Support. | March 2014 | May 2017 |
NCT05002088 | Completed | Portico Valve-in-Valve Retrospective Registry | October 21, 2021 | December 29, 2023 | |
NCT02448927 | Completed | Phase 3 | The preDIlatation in tRanscathEter aortiC Valve implanTation Trial | May 2015 | May 2, 2018 |
NCT02472106 | Completed | Impact of Postdilatation With the InterValve V8 Aortic Valvuloplasty Balloon Following TAVI Procedure | June 2015 | August 2016 | |
NCT02481258 | Completed | Phase 2 | A Study Evaluating the Effects of Ataciguat (HMR1766) on Aortic Valve Calcification | June 2015 | December 1, 2019 |
NCT02510482 | Completed | Biological Variation of Cardiac Biomarkers in Aortic Valve Stenosis | August 2015 | October 16, 2017 | |
NCT04810195 | Completed | Early neo2 Registry of the Acurate neo2 TAVI Prosthesis | September 1, 2020 | March 15, 2022 | |
NCT02551588 | Completed | Valvular Aortic Stenosis: Study of Myocardiac Fibrosis by Magnetic Resonance Imagery | December 2012 | November 2015 | |
NCT02559011 | Completed | Assessment of Arrhythmias in Patients Undergoing Transcatheter Aortic Valve Implantation Using a Small Insertable Cardiac Monitoring Device | March 2016 | November 16, 2020 | |
NCT02592369 | Completed | CoreValve™ Evolut R™ FORWARD Study | January 2016 | February 6, 2020 | |
NCT04704258 | Completed | N/A | NAUTILUS CE-mark Trial of the FLOWer Cerebral Embolic Protection Device | May 3, 2021 | June 6, 2023 |
NCT02624934 | Completed | Podocan and Wnt Pathway in Left Ventricular Remodeling of Aortic Stenosis | October 2015 | June 2020 | |
NCT02671474 | Completed | N/A | Valve Leaflet Motion in Sutureless Bioprosthetic Aortic Valves | January 2016 | May 2016 |
NCT02726087 | Completed | N/A | Quality of Life After Ministernotomy Versus Full Sternotomy Aortic Valve Replacement | March 20, 2016 | October 20, 2019 |
NCT02727504 | Completed | Low Flow Low Gradient Aortic Stenosis Relevance of the (re)Search for a Contractile Reserve | May 11, 2016 | January 6, 2020 | |
NCT02729519 | Completed | N/A | TAVI Without Balloon Predilatation (of the Aortic Valve ) SAPIEN 3 | June 8, 2016 | August 9, 2018 |
NCT02738853 | Completed | N/A | The Medtronic TAVR 2.0 US Clinical Study | April 2016 | December 15, 2021 |
NCT02746809 | Completed | N/A | Medtronic CoreValve Evolut R U.S. Clinical Study (Evolut 34R Addendum) | June 2016 | December 15, 2021 |
NCT02758964 | Completed | Evaluation of Cerebral Thrombembolism After TAVR | September 2016 | January 2019 | |
NCT04557345 | Completed | Evaluation of the Inflammatory Response in Post-operated Aortic Valve Replacement Patients. | January 1, 1990 | August 1, 2020 | |
NCT02781896 | Completed | N/A | Direct Left Ventricular Rapid Pacing Via the Valve Delivery Guide-wire in TAVI | May 12, 2017 | June 29, 2018 |
NCT02792452 | Completed | Clinical Value of Stress Echocardiography in Moderate Aortic Stenosis | September 2016 | December 31, 2019 | |
NCT02805309 | Completed | N/A | Home-Based Exercise Program For Recovery After Transcatheter Aortic Valve Replacement | August 1, 2017 | May 6, 2020 |
NCT02815514 | Completed | German TAVI-Register | January 2009 | December 2016 | |
NCT02817789 | Completed | Phase 3 | Safety Profile Evaluation of TICagrelor Alone Compared to a Combination of Lysine Acetylsalicylate-Clopidogrel in the Context of Transcatheter Aortic Valve Implantation (TAVI) | May 9, 2016 | May 30, 2018 |
NCT04548726 | Completed | Hemodynamic Matched Comparison of the Balloon-Expandable Transcatheter Heart Valves Myval and Sapien-3 for the Treatment of Aortic Stenosis | June 1, 2018 | September 30, 2020 | |
NCT02833948 | Completed | Phase 3 | Comparison of a Rivaroxaban-based Strategy With an Antiplatelet-based Strategy Following Successful TAVR for the Prevention of Leaflet Thickening and Reduced Leaflet Motion as Evaluated by Four-dimensional, Volume-rendered Computed Tomography (4DCT) | May 2016 | March 6, 2019 |
NCT04527367 | Completed | Epidemiology and Long-term Outcome of Patients With VHD | January 2006 | January 2022 | |
NCT02838680 | Completed | N/A | Transfemoral Replacement of Aortic Valve With HLT MeriDIAN Valve Feasibility Trial CANADA | December 2016 | October 31, 2022 |
NCT02847546 | Completed | Evaluation of the BARD® True™ Flow Valvuloplasty Perfusion Catheter for Aortic Valve Dilatation | September 2016 | October 2016 | |
NCT04503655 | Completed | N/A | Multicenter Study Evaluating the Efficacy of an Intervention Aimed at Reducing the Length of Stay After Transfemoral Transcatheter Aortic Valve Implantation | December 16, 2020 | February 9, 2022 |
NCT04459208 | Completed | N/A | Randomized Comparison of Catheter-based Strategies for Interventional Access Site Closure During Transfemoral Transcatheter Aortic Valve Implantation | June 26, 2020 | August 4, 2021 |
NCT04437303 | Completed | Phase 4 | Periprocedural Continuation Versus Interruption of Oral Anticoagulant Drugs During Transcatheter Aortic Valve Implantation (POPular PAUSE TAVI) | November 25, 2020 | May 22, 2024 |
NCT02971020 | Completed | N/A | Evaluating the Risk of Cognitive Impairment After Surgical and Transcatheter Aortic Valve Replacement | May 2016 | March 21, 2018 |
NCT02974660 | Completed | Phase 4 | Protamine Sulfate During Transcatheter Aortic Valve Implantation | December 2016 | September 2020 |
NCT02989558 | Completed | Phase 3 | A Trial to Assess the Safety and Efficacy of Prophylactic TicagrelOr With Acetylsalicylic Acid Versus CLopidogrel With Acetylsalicylic Acid in the Development of Cerebrovascular EMbolic Events During TAVI | December 2016 | February 1, 2021 |
NCT04400513 | Completed | Development of an Algorithm to Differentiate Heart Murmurs Using Electronic Stethoscopes | June 25, 2020 | December 31, 2021 | |
NCT03011346 | Completed | N/A | Safety and Efficacy of the Symetis ACURATE Neo/TF Compared to the Edwards SAPIEN 3 Bioprosthesis. | February 8, 2017 | February 16, 2022 |
NCT04385459 | Completed | Severe Aortic Valve Stenosis and Concomitant Coronary Artery Disease in Patients Undergoing TAVI | December 13, 2018 | December 24, 2020 | |
NCT03056573 | Completed | N/A | Assessment of the St Jude Medical Portico Resheathable Aortic Valve System-Alternative Access | March 29, 2017 | July 5, 2019 |
NCT03667248 | Completed | Sizing of the PERCEVAL® Sutureless Aortic Valve Prosthesis Using the CT: a Feasibility Study | May 2, 2018 | March 31, 2019 | |
NCT03715894 | Completed | Prospective Arm of Conduct - Edwards SAPIEN3 PPI Registry | December 1, 2018 | March 30, 2023 | |
NCT03740425 | Completed | Transfusion Requirements in Transcatheter Aortic Valve Implantation (TRITAVI) Study | January 1, 2018 | March 1, 2019 | |
NCT03753126 | Completed | N/A | Stent Geometry in Sutureless Bioprosthetic Valves | January 2016 | November 2018 |
NCT03769545 | Completed | Mortality Post-TAVI and Correlation With Haemodynamic Parameters. | January 1, 2008 | December 31, 2017 | |
NCT03779620 | Completed | N/A | Valvosoft First-In-Man Study in Severe Symptomatic Aortic Stenosis | March 13, 2019 | September 27, 2023 |
NCT03863899 | Completed | N/A | Analgesia in Patients Undergoing Transfemoral Transcatheter Aortic Valve Implantation (TF-TAVI) | July 2, 2018 | December 31, 2019 |
NCT03807921 | Completed | Phase 4 | Anticoagulation for Aortic Bioprosthesis (ANTIPRO) | January 1, 2019 | December 31, 2019 |
NCT03811119 | Completed | N/A | Manta™ Versus Suture-based Closure After Transcatheter Aortic Valve Implantation Trial | October 30, 2018 | April 30, 2020 |
NCT00636987 | Completed | N/A | Aortic or Mitral Valve Replacement With the Biocor and Biocor Supra | April 2007 | March 2016 |
NCT05904912 | Completed | N/A | PENG Block forTranscatheter Aortic Valve Implantation | June 10, 2023 | December 7, 2023 |
NCT00727181 | Completed | N/A | An Observational, Prospective Evaluation of the Trifecta™ Valve | November 2007 | December 2010 |
NCT00820599 | Completed | N/A | PREVAIL-TF: Transfemoral Placement of Aortic Balloon Expandable Transcatheter Valves Trial (Europe) | December 2008 | March 2016 |
NCT00965679 | Completed | X-ray Fluoroscopy Fused With Computed Tomography (XFC) Technical Development | August 6, 2009 | May 27, 2010 | |
NCT01015612 | Completed | N/A | CoreValve® System Australia/New Zealand Clinical Study | August 2008 | September 2016 |
NCT01051310 | Completed | N/A | Medtronic CoreValve REDO Study | June 2008 | January 2011 |
NCT01051518 | Completed | N/A | Clinical Evaluation of Percutaneous Implantation of the Medtronic CoreValve Aortic Valve Prosthesis (18Fr-Study) | May 2006 | June 2013 |
NCT01092442 | Completed | CryoValve SG Pulmonary Human Heart Valve Post Clearance Study | January 2010 | December 2014 | |
NCT01113983 | Completed | N/A | PREVAIL-J - Transfemoral & Transapical Placement of Aortic Balloon Expandable Transcatheter Valves Trial (Japan) | April 1, 2010 | May 2016 |
NCT05750927 | Completed | Aortic Stenosis With COmplex PCI (ASCOP) Features Retrospective Registry on Contemporary Management and Outcomes | December 1, 2022 | December 31, 2023 | |
NCT01171625 | Completed | N/A | Carpentier-Edwards PERIMOUNT Magna Ease Pericardial Bioprosthesis, Model 3300TFX | October 2007 | September 2018 |
NCT01236469 | Completed | CryoValve® SG Aortic Human Heart Valve Combination Study | June 2010 | February 2012 | |
NCT01238835 | Completed | N/A | PREVAIL-TA: Placement of Aortic Balloon Expandable Transcatheter Valves Trial (Europe) | September 2009 | March 2016 |
NCT01251328 | Completed | N/A | Near INfrared Spectroscopy in Aortic valvE ReplacemenT | December 2010 | April 2012 |
NCT01348438 | Completed | N/A | Transapical Implantation of the Medtronic Engager Transcatheter Aortic Valve Implantation System - The Engager European Pivotal Trial | September 12, 2011 | January 25, 2018 |
NCT01383720 | Completed | N/A | REpositionable Percutaneous Replacement of Stenotic Aortic Valve Through Implantation of Lotus™ Valve SystEm | April 2012 | May 9, 2017 |
NCT01390129 | Completed | N/A | Remote Ischemic Preconditioning in Aortic Valve Surgery | July 2011 | October 2012 |
NCT01419015 | Completed | N/A | PREVAIL-20J - Transfemoral Placement of 20mm Aortic Balloon Expandable Transcatheter Valve Trial | June 2011 | December 2017 |
NCT01437098 | Completed | N/A | Clinical Evaluation of MDT-2111 in Subjects With Symptomatic Severe Aortic Stenosis | October 2011 | November 27, 2018 |
NCT01445171 | Completed | N/A | Surgical Treatment of Aortic Stenosis With a Next Generation Surgical Aortic Valve | January 2010 | December 2017 |
NCT01497418 | Completed | Long Term Follow-up of the 23mm Portico™ Aortic Valve Implant and the St. Jude Medical Transfemoral Delivery System | December 2011 | March 2014 | |
NCT01514994 | Completed | N/A | Valvuloplasty Scoring Balloon Catheter First-in-Man Study | June 2012 | September 2015 |
NCT01593917 | Completed | Trifecta™ Long Term Follow-Up (LTFU) Study | July 2, 2012 | September 26, 2019 | |
NCT01624870 | Completed | CoreValve Advance-II Study: Prospective International Post-market Study | October 2011 | March 2014 | |
NCT01634269 | Completed | N/A | Clinical Evaluation of MDT-2111 in Subjects With Small Aortic Annuli and Symptomatic Severe Aortic Stenosis | July 2012 | September 2019 |
NCT01635244 | Completed | N/A | Hemodynamic Comparison of Tissue Aortic Valves | July 2012 | December 2015 |
NCT01642134 | Completed | Phase 4 | Dual Antiplatelet Therapy Versus Oral Anticoagulation for a Short Time to Prevent Cerebral Embolism After TAVI | April 2013 | June 30, 2019 |
NCT01651052 | Completed | N/A | Clinical Trial of the Edwards Aortic Bioprosthesis, Model 11000 | July 2011 | July 2018 |
NCT05672823 | Completed | N/A | Upper Extremity Versus Lower Extremity Accessory Access Sites During Transcatheter Aortic Valve Implantation | November 28, 2022 | December 15, 2023 |
NCT05672160 | Completed | Overal Survival After TAVI According to Sarcopenia | January 1, 2022 | January 2, 2023 | |
NCT01700439 | Completed | N/A | Surgical Treatment of Aortic Stenosis With a Next Generation, Rapid Deployment Surgical Aortic Valve | September 26, 2012 | May 26, 2021 |
NCT05662748 | Completed | Comparison Between Manta and Prostar Closure Devices | January 20, 2020 | March 30, 2021 | |
NCT04333875 | Completed | Morbidity and Mortality Due to Deferral of Aortic Valve Replacement in Patients With Severe Aortic Stenosis | March 20, 2020 | April 30, 2021 | |
NCT03326778 | Completed | Registry to Gather Long-time Results After Surgical Aortic Valve Replacement With a "Rapid Deployment Aortic Valve Prothesis (Edwards Intuity) Combined With Bypss Surgery (CABG) | November 26, 2017 | July 1, 2020 | |
NCT03347032 | Completed | N/A | Remote Ischemic Preconditioning for Renal Protection in TAVI | February 13, 2018 | December 30, 2018 |
NCT00475267 | Completed | N/A | Aortic Valve Replacement With Trifecta(TM) | May 2007 | January 2012 |
NCT04274751 | Completed | Comparison of Transaxillary and Transfemoral Fully-percutaneous Approaches for Transcatheter Aortic Valve Implantation | July 1, 2019 | June 30, 2020 | |
NCT03385915 | Completed | Finnish Registry of Transcatheter and Surgical Aortic Valve Replacement for Aortic Valve Stenosis: FinnValve Registry | December 1, 2017 | March 9, 2020 | |
NCT03417011 | Completed | FORWARD PRO Study Interventional Post-market Study With the Evolut™ PRO System | February 26, 2018 | February 26, 2024 | |
NCT03422770 | Completed | N/A | Ultrasonic Markers for Myocardial Fibrosis and Prognosis in Aortic Stenosis | January 9, 2018 | June 30, 2020 |
NCT00475709 | Completed | N/A | Aortic Valve Replacement With Trifecta(TM) | June 2007 | January 2012 |
NCT03458806 | Completed | Phono- and Electrocardiogram Assisted Detection of Valvular Disease | February 22, 2018 | November 11, 2019 | |
NCT03483051 | Completed | Phase 2 | Targeting Pulsatile Load to Increase Exercise Capacity and Quality of Life After Aortic Valve Replacement for Severe Aortic Stenosis (PULSE AS) | May 1, 2018 | May 23, 2019 |
NCT03497611 | Completed | Edwards SAPIEN 3 PPI Registry | April 30, 2018 | March 3, 2019 | |
NCT04131127 | Completed | Sentinel Low Risk Registry | January 7, 2020 | August 19, 2020 | |
NCT03570190 | Completed | Registry to Evaluate the Impact of a Valve Coordinator on Aortic Stenosis / TAVI Outcome - (German Pilot) | December 20, 2018 | December 19, 2019 | |
NCT04103931 | Completed | N/A | Impact of a Patient Decision Aid for Treatment of Aortic Stenosis | September 23, 2019 | September 1, 2021 |
NCT03588247 | Completed | Cerebrovascular EveNts in Patients Undergoing TranscathetER Aortic Valve Implantation With Balloon-expandable Valves Versus Self-expandable Valves. | August 1, 2017 | January 1, 2023 | |
NCT04096859 | Completed | PremiCron Suture for Cardiac Valve Repair | November 22, 2019 | January 13, 2022 | |
NCT03617406 | Completed | N/A | Volume Challenge Added to DSE in the Diagnosis of Severe LFLGAS | May 31, 2018 | December 31, 2020 |
NCT04053192 | Completed | Evaluation of BAV in Different Hemodynamic Entities of Severe AS | June 1, 2018 | August 31, 2019 | |
NCT04012060 | Completed | N/A | Patient Reported Health-Related Quality of Life After Limited Access and Conventional Aortic Valve Replacement | June 13, 2016 | July 7, 2020 |
NCT03966417 | Completed | N/A | Exercise Training After Transcatheter Aortic Valve Implantation | June 18, 2019 | December 1, 2020 |
NCT03950440 | Completed | Assessing the Incidence of Postoperative Delirium Following Aortic Valve Replacement | September 23, 2018 | July 9, 2020 | |
NCT03074838 | Completed | N/A | Inflammatory Response to Aortic Valve Replacement | December 1, 2012 | December 31, 2013 |
NCT03087552 | Completed | Mini-invasive Balloon Aortic Valvuloplasty | March 11, 2017 | April 20, 2021 | |
NCT03107897 | Completed | N/A | Prehabilitation for Patients Undergoing Transcatheter Aortic Valve Replacement | August 17, 2016 | April 30, 2021 |
NCT03107923 | Completed | Better Patient Selection to Transcatheter Aortic Valve Implantation | April 26, 2017 | March 31, 2021 | |
NCT03112629 | Completed | Study to Improve Outcomes in Aortic Stenosis | March 23, 2017 | April 3, 2019 | |
NCT00256165 | Completed | Phase 4 | REST Study: Left Ventricular Regression European Study | January 2006 | July 2008 |
NCT03173534 | Completed | N/A | WATCH-TAVR, WATCHMAN for Patients With Atrial Fibrillation Undergoing Transcatheter Aortic Valve Replacement | December 15, 2017 | December 6, 2022 |
NCT03181997 | Completed | Outcomes of Transcatheter Aortic Valve Implantation in Oncology Patients With Severe Aortic Stenosis | January 1, 2017 | March 1, 2019 | |
NCT03186339 | Completed | Validation of the "TASQ" in Patients Undergoing SAVR or TF-TAVI | September 8, 2017 | January 13, 2020 | |
NCT03192813 | Completed | Safety and Efficacy Comparison Of Two TAVI Systems in a Prospective Randomized Evaluation II | April 20, 2017 | June 4, 2020 | |
NCT03196596 | Completed | Added Value of Patient-specific Computer Simulation in Transcatheter Aortic Valve Implantation (TAVI) | May 23, 2017 | January 31, 2019 | |
NCT03243890 | Completed | N/A | The Aortic Valve DECalcification (AVADEC) Trial | January 12, 2018 | May 1, 2021 |
NCT03248232 | Completed | Assessments of Thrombus Formation in TAVI | August 1, 2017 | June 30, 2018 | |
NCT03270124 | Completed | N/A | A pragmatiC sTrategy to Promote actIVity and Enhance Quality of Life AFTER Transcatheter Aortic Valve Replacement | November 7, 2017 | March 25, 2020 |
NCT03284827 | Completed | Phase 4 | Anticoagulant Versus Dual Antiplatelet Therapy for Preventing Leaflet Thrombosis and Cerebral Embolization After Transcatheter Aortic Valve Replacement | March 15, 2018 | November 5, 2021 |
NCT04344353 | Completed | Analysis and Comparative Evaluation of Aortic Calcium by Computed Tomography and Histopathology in Patients With Aortic Stenosis | January 1, 2020 | January 1, 2021 | |
NCT05714293 | Enrolling by invitation | N/A | CT-evaluation of Coronary Ostia Height After Surgical Aortic Valve Replacement. | January 11, 2023 | January 10, 2025 |
NCT04372381 | Enrolling by invitation | N/A | Supra-Annular vs. Annular ValvEs for Small Annuli | May 12, 2020 | June 2025 |
NCT05830760 | Not yet recruiting | N/A | Expression of Sodium-glucose Co-transporter 2 in Human Heart | June 2023 | October 2025 |
NCT06420830 | Not yet recruiting | Valve Performance of the SAPIEN 3 Ultra RESILIA Valve: A Prospective Registry With Central Echocardiography Analysis. | June 1, 2024 | September 1, 2034 | |
NCT05836311 | Not yet recruiting | Single Perclose Escalation Technique for Vascular Closure in TAVR | July 19, 2023 | February 19, 2025 | |
NCT05861648 | Not yet recruiting | Phase 2 | Folic Acid Supplementation in Calcific Aortic Valve Disease | July 1, 2023 | July 1, 2028 |
NCT06015997 | Not yet recruiting | Prevalence of ATTR Cardiac Amyloidosis in Patients Undergoing TAVR | October 1, 2023 | November 1, 2025 | |
NCT04636073 | Not yet recruiting | N/A | The Leaflex™ Early Feasibility Study | December 2024 | December 2025 |
NCT05536310 | Not yet recruiting | TAVIS Registry - Trilogy Heart Valve System for Management of Patients With Aortic Valve Disease | March 2023 | October 2027 | |
NCT03575039 | Not yet recruiting | N/A | VitaFlowTM II Transcatheter Aortic Valve System Study | August 2018 | December 2024 |
NCT05672836 | Not yet recruiting | Phase 4 | ENAVOgliflozin Outcome Trial in Patients With Severe Aortic Stenosis After Transcatheter Aortic Valve Replacement | December 2023 | April 2026 |
NCT05875675 | Not yet recruiting | Phase 2 | Effects of Pioglitazone in Calcific Aortic Valve Disease | July 1, 2023 | July 1, 2028 |
NCT06283940 | Not yet recruiting | N/A | Exercise-based Cardiac Rehabilitation in Patients With Aortic Stenosis After Transcatheter Aortic Valve Implantation | August 2024 | January 2026 |
NCT05696145 | Not yet recruiting | Aortic Stenosis Associated Left Ventricular Remodeling - An Investigation of Genetic and Gender Specific Differences in 170 Patients Undergoing Aortic Valve Replacement Surgery | March 1, 2023 | January 31, 2025 | |
NCT05895097 | Not yet recruiting | N/A | Conventional Versus Left Bundle Branch Pacing in TAVI | June 15, 2023 | June 15, 2026 |
NCT06099665 | Not yet recruiting | N/A | Addressing Undertreatment and Health Equity in Aortic Stenosis Using an Integrated EHR Platform | April 2024 | December 2024 |
NCT05721170 | Not yet recruiting | Phase 4 | Impact of Beta Blockers on TAVI (BETA-TAVI) | March 1, 2024 | January 31, 2025 |
NCT05977257 | Not yet recruiting | VitaFlow® Transcatheter Aortic Valve Replacement System Pre-market Trial Long Term Follow Up (VITAL) | July 30, 2023 | October 30, 2028 | |
NCT06269640 | Not yet recruiting | N/A | NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Early Feasibility Study | June 23, 2024 | October 1, 2027 |
NCT06215378 | Not yet recruiting | Phase 3 | Antagonization of Heparin With Protamine Sulfate After TAVI | February 1, 2024 | February 1, 2027 |
NCT05528211 | Not yet recruiting | Safety and Efficacy of Emergent TAVI in Patients With Severe AS | September 1, 2022 | November 1, 2028 | |
NCT05991271 | Not yet recruiting | N/A | Venus-Vitae Pivotal Study Smart-Align Study | October 31, 2023 | June 30, 2029 |
NCT06449469 | Recruiting | N/A | The Nordic Aortic Valve Intervention Trial 4 (NOTION-4) | May 1, 2021 | January 1, 2029 |
NCT01737528 | Recruiting | STS/ACC Transcatheter Valve Therapy Registry (TVT Registry) | June 2012 | June 2035 | |
NCT01805739 | Recruiting | Multi Modal Cardiac Imaging Prior Transcatheter Aortic Valve Implantation | January 2013 | December 2030 | |
NCT02000115 | Recruiting | N/A | Portico Re-sheathable Transcatheter Aortic Valve System US IDE Trial | May 2014 | July 2025 |
NCT02984449 | Recruiting | N/A | Preventive Heart Rehabilitation to Prevent Complications in Patients Undergoing Elective Open Heart Surgery | May 3, 2017 | August 31, 2025 |
NCT03143361 | Recruiting | Prospective European Multicenter Study on Aortic Valve Replacement: (E-AVR Registry) | November 1, 2017 | October 2029 | |
NCT03192774 | Recruiting | The Prospective Segeberg TAVI Registry | September 2007 | December 2032 | |
NCT03298178 | Recruiting | ASAN Medical Center Aortic Valve Replacement Registry | December 1, 2017 | December 2031 | |
NCT03303612 | Recruiting | N/A | Clinical Monitoring Strategy Versus Electrophysiology-guided Algorithmic Approach With a New LBBB After TAVI | October 15, 2017 | December 2026 |
NCT03360591 | Recruiting | N/A | Functional Assessment In TAVI: FAITAVI | November 24, 2017 | November 2024 |
NCT03453567 | Recruiting | Evaluation of Effectiveness and Safety of Aortic Valve Replacement in Routine Clinical Practice | May 10, 2018 | December 15, 2030 | |
NCT03470246 | Recruiting | N/A | Personalized Activity Intervention in Rehabilitation After Cardiac Operations (the PACO Trial) | April 6, 2018 | March 1, 2028 |
NCT03728049 | Recruiting | N/A | Von Willebrand Factor Point-of-care Testing to Improve Minimally Invasive TAVI Outcomes | December 18, 2019 | December 2025 |
NCT03972644 | Recruiting | N/A | Danish National Randomized Study on Early Aortic Valve Replacement in Patients With Asymptomatic Severe Aortic Stenosis | January 1, 2020 | September 1, 2029 |
NCT04171726 | Recruiting | Phase 3 | Rotterdam EDOXaban Leaflet Evaluation in Patients After Transcatheter Aortic Valve Implantation | August 1, 2019 | September 1, 2023 |
NCT04227002 | Recruiting | Hamburg AoRtic Valve cOhoRt | September 1, 2019 | September 1, 2049 | |
NCT04231461 | Recruiting | Quality of Life After Cardiac Surgery | July 19, 2019 | April 30, 2024 | |
NCT04275726 | Recruiting | N/A | LANDMARK Trial: a Randomised Controlled Trial of Myval THV | November 4, 2020 | December 31, 2033 |
NCT04312139 | Recruiting | Serum and Cellular Biomarkers for Aortic Valve Stenosis | March 1, 2020 | September 2025 | |
NCT04358692 | Recruiting | N/A | Measurement of Myocardial Stiffness Using Elastometry in Patients With Aortic Stenosis | June 30, 2020 | June 30, 2024 |
NCT04414865 | Recruiting | VitaFlow™ Transcatheter Aortic Valve System Post-market Study-The LAUNCH Study | April 26, 2020 | December 30, 2027 | |
NCT04464655 | Recruiting | A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease | December 12, 2019 | January 31, 2025 | |
NCT04473443 | Recruiting | Addition of Computer Simulations to Minimize Adverse Events After Transcatheter Aortic Valve Implantation | August 1, 2020 | June 30, 2023 | |
NCT04533282 | Recruiting | Epitranscriptomic Blood Biomarkers for Coronary Artery Disease - A Prospective Cohort Study (IHD-EPITRAN) | November 10, 2020 | December 31, 2025 | |
NCT04613193 | Recruiting | N/A | Blood Pressure Reduction in Patients With Asymptomatic Aortic VALVE Stenosis | March 1, 2019 | June 1, 2031 |
NCT04703699 | Recruiting | Myval Global Study of Myval™ THV Series Implanted in Patients With Native Severe Aortic Valve Stenosis. | August 7, 2020 | November 30, 2028 | |
NCT04827238 | Recruiting | Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE TAVR) | August 30, 2021 | December 31, 2023 | |
NCT04882488 | Recruiting | Correlation of FFR and iFR With Cardiac PET Perfusion in Patients With Severe Aortic Valve Stenosis | June 1, 2021 | June 30, 2024 | |
NCT04889872 | Recruiting | N/A | PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR | October 12, 2021 | June 2037 |
NCT04893603 | Recruiting | N/A | To Evaluate Safety and Effectiveness of Transcatheter Aortic Valve System in Patients With Severe Aortic Stenosis | December 16, 2020 | December 31, 2026 |
NCT05010980 | Recruiting | Early Detection of Cardiac Amyloidosis | August 1, 2021 | September 2023 | |
NCT05015452 | Recruiting | The Leipzig TAVI Registry | March 1, 2020 | December 31, 2030 | |
NCT05036018 | Recruiting | N/A | RanDOmized stUdy Comparing Both Latest Generation Self-Expanding Valves and a Minimalist approaCH vs. Standard Of Care In transCathEter Aortic Valve Implantation | August 30, 2021 | October 31, 2033 |
NCT05078619 | Recruiting | N/A | Percutaneous Coronary Intervention Before Transcatheter Aortic Valve Implantation | October 5, 2021 | August 22, 2028 |
NCT05146037 | Recruiting | N/A | INTERvention With Cerebral Embolic Protection in Transcatheter Aortic Valve Implantation (INTERCEPTavi) | September 1, 2021 | December 2023 |
NCT05162742 | Recruiting | Phase 3 | Colchicine and Inflammation in Aortic Stenosis | December 22, 2022 | December 22, 2025 |
NCT05172973 | Recruiting | N/A | ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves | November 22, 2023 | February 2034 |
NCT05189886 | Recruiting | Transcatheter Aortic Valve Replacement (TAVR) Double Balloon Valvuloplasty | November 10, 2021 | December 2024 | |
NCT05237804 | Recruiting | N/A | Evaluation of an Intervention to Reduce the Time to Treatment for TAVI Patients | October 26, 2022 | December 31, 2024 |
NCT05278585 | Recruiting | Pacing the Atrium to Confirm or Exclude Pacemaker Indication in TAVI | September 1, 2022 | June 2024 | |
NCT05283356 | Recruiting | Phase 4 | Single Antiplatelet Treatment With Ticagrelor or Aspirin After Transcatheter Aortic Valve Implantation | January 21, 2022 | June 30, 2025 |
NCT05295628 | Recruiting | N/A | Evaluation of Safety and Effectiveness of the EMBLOK EPS During TAVR | October 17, 2023 | February 1, 2025 |
NCT05386173 | Recruiting | Effect of Fetal Aortic Valvuloplasty on Outcomes | January 1, 2021 | December 31, 2029 | |
NCT05404100 | Recruiting | Effects of Aortic Valve Replacement on Myocardial T1 Values in Severe Aortic Valve Stenosis | April 1, 2021 | April 1, 2024 | |
NCT05454150 | Recruiting | N/A | Balloon-Expandable Versus Self-expanding Transcatheter Heart Valve for Treatment of Symptomatic Native Aortic Valve Stenosis (BEST) | April 19, 2023 | July 19, 2025 |
NCT05459233 | Recruiting | N/A | Valve Hemodynamic Optimization Based on Doppler-Echocardiography vs Catheterization Measurements Following ViV TAVR | January 11, 2023 | September 1, 2029 |
NCT05479188 | Recruiting | N/A | Comparative Analysis of the Microcirculation During Cardiac Surgery With Minimal Invasive Versus Conventional Extracorporeal Circulation | December 1, 2021 | December 31, 2023 |
NCT05481008 | Recruiting | Cardiac Output, Cerebral Perfusion and Cognition in Patients Undergoing TAVI | August 28, 2020 | August 2023 | |
NCT05487612 | Recruiting | N/A | MiECC Versus Conventional Cardiopulmonary Bypass in Cardiac Surgery (MiECS) | May 26, 2022 | March 31, 2026 |
NCT05491070 | Recruiting | N/A | Comparison of Different Vascular Closure Device in TAVI | March 20, 2018 | June 30, 2023 |
NCT05541679 | Recruiting | N/A | Comparison of Left Bundle Branch Area Versus Right Ventricular Septal Pacing in Patients With High-degree Conduction Disease After Transcatheter Aortic Valve Replacement (Left Bundle BRAVE) | December 28, 2022 | December 31, 2025 |
NCT05550896 | Recruiting | Platelet Adhesion in the Pathobiology of Aortic Stenosis | January 3, 2023 | June 1, 2028 | |
NCT05567809 | Recruiting | Defining Exercise Hemodynamics and Function After Transcatheter Aortic Valve Replacement (DEFINE-TAVR) Study. | October 25, 2022 | October 2024 | |
NCT05572710 | Recruiting | Avalus European Registry - an Observational Study to Evaluate Safety and Efficacy in a Real World Population | June 10, 2020 | December 31, 2025 | |
NCT05601453 | Recruiting | The ReTAVI Prospective Observational Registry | September 5, 2023 | December 2026 | |
NCT05603026 | Recruiting | N/A | MRI in Transcatheter Aortic Valve Replacement Patients | November 21, 2023 | December 30, 2024 |
NCT05641064 | Recruiting | Phase 3 | Evaluation of Intraoperative Dexmedetomidine Use in Patients Undergoing Surgical Aortic Valve Replacement | November 22, 2022 | December 31, 2025 |
NCT05670041 | Recruiting | N/A | Re-hospitalisation After Transcatheter Aortic Valve Implantation | January 16, 2023 | March 16, 2025 |
NCT05708118 | Recruiting | Progression of Ascending Aorta Diameters in Bicuspid Aortic Valve After Transcatheter or Surgical Replacement. | January 20, 2023 | January 21, 2024 | |
NCT05709652 | Recruiting | N/A | Impact of Fast-rotation Coronary CT in Patients Undergoing Aortic Stenosis Workup | February 27, 2024 | June 3, 2026 |
NCT05711186 | Recruiting | N/A | Structured Shared Decision Making for Patients Undergoing SAVR or TAVR | April 17, 2023 | May 30, 2026 |
NCT05758662 | Recruiting | The Effect of Subclinical Leaflet Thrombosis and Prosthesis Type on Transcatheter Aortic Valve Degeneration (POPular PET TAVI) | November 16, 2023 | November 2025 | |
NCT05758909 | Recruiting | Evaluation of the Viability and Safety of Early Discharge Protocol After TAVI Implantation | April 4, 2023 | December 1, 2025 | |
NCT05774691 | Recruiting | Phase 4 | Routine Versus Selective Protamine Administration to Reduce Bleeding Complications After Transcatheter Aortic Valve Implantation (POPular ACE TAVI) | November 1, 2023 | December 31, 2025 |
NCT05778773 | Recruiting | OUTcomes Evaluation of Current Therapeutic STrategies for Severe Aortic Valve steNosis anD the agING Population in ITALY | November 1, 2018 | November 2029 | |
NCT05779787 | Recruiting | COronary Re-engageMent aFter randOm NavitoR alignmenT (COMFORT STUDY) | February 15, 2023 | May 15, 2027 | |
NCT05788770 | Recruiting | N/A | Preoperative CT-imaging With Patient-specific Computer Simulation in Transcatheter Aortic Valve Replacement: a Randomized Controlled Trial | April 6, 2022 | December 31, 2024 |
NCT05862558 | Recruiting | Intravascular Lithotripsy in High Risk Calcified Iliac Anatomy for Transfemoral TAVR | March 30, 2023 | December 2025 | |
NCT05864456 | Recruiting | N/A | Prizvalve Pro™ Transcatheter Aortic Valve Replacement Study | July 5, 2023 | May 2028 |
NCT05864625 | Recruiting | N/A | Comparison of Hemodynamic Stability During Anesthesia Using Remimazolam and Sevoflurane in Minimally Invasive AVR | June 29, 2023 | June 30, 2024 |
NCT05892588 | Recruiting | Prevalence Study of Cardiovascular Diseases in a Population ≥ 65 Years in Italy | June 1, 2022 | July 1, 2023 | |
NCT05902897 | Recruiting | Aortic or Mitral Valve Replacement With the Braile Biomédica® Bovine Pericardium Valvular Bioprosthesis | January 1, 2023 | October 30, 2023 | |
NCT05909748 | Recruiting | N/A | FIH Study of the GEMINUS TAVI System in Patients With Severe Symptomatic Aortic Stenosis | May 21, 2023 | April 2030 |
NCT05930899 | Recruiting | Translational-Omics in Aortic Stenosis (TOmAS) Biobank | October 12, 2017 | January 1, 2040 | |
NCT05932615 | Recruiting | N/A | ENVISION IDE Trial: Safety and Effectiveness of NAVITOR in Transcatheter Aortic Valve Implantation | March 19, 2024 | April 2036 |
NCT05956652 | Recruiting | Hydra Registry - Italy Experience | July 1, 2023 | July 31, 2029 | |
NCT06000943 | Recruiting | Ischemic And Bleeding Risk Assessment After TAVR | August 1, 2023 | December 15, 2024 | |
NCT06040398 | Recruiting | The JUMPSTART Program: Encouraging Early Mobilization and Optimizing Recovery of TAVR Patients' Post-hospital Discharge | March 1, 2023 | March 31, 2024 | |
NCT06049654 | Recruiting | N/A | Comparison of Allegra vs Sapien Transcatheter Aortic Valves in Valve-In-Valve Indication | February 1, 2024 | November 1, 2025 |
NCT06103591 | Recruiting | N/A | Controlled Arterial Protection to Ultimately Remove Embolic Material | December 27, 2023 | March 2024 |
NCT06154642 | Recruiting | Perioperative Hemodynamic and Microcirculatory Physiological Study During TAVI | May 8, 2024 | July 31, 2024 | |
NCT06171802 | Recruiting | Phase 4 | EMPagliflozin After Aortic Valve Replacement | February 14, 2024 | January 2026 |
NCT06235385 | Recruiting | European Association of Cardiovascular Imaging Multiple and Mixed Valvular Disease Study | February 7, 2024 | August 1, 2029 | |
NCT06342635 | Recruiting | Hydra Single-centre Experience - Copenhagen, Denmark | June 18, 2024 | October 31, 2026 | |
NCT06404437 | Recruiting | Detection of Aortic Stenosis With Smartphone Auscultation Using Machine Learning (HEARTBEAT-Pilot) | March 9, 2023 | October 1, 2024 | |
NCT02361996 | Suspended | Quantitative Measurement of Myocardial Perfusion by Cardiac CT in Patients | February 2015 | April 2022 | |
NCT03843320 | Suspended | Impact of SAVR and TAVR on Patient's Activity and Mobility | December 2021 | December 2024 | |
NCT04142658 | Terminated | Phase 3 | PROACT Xa - A Trial to Determine if Participants With an On-X Aortic Valve Can be Maintained Safely on Apixaban | May 1, 2020 | December 12, 2022 |
NCT03805711 | Terminated | N/A | HLT Meridian Valve CE Mark Trial | July 12, 2019 | September 20, 2019 |
NCT00590135 | Terminated | Phase 4 | The Effect of Lipitor on Aortic Stenosis | August 2000 | April 26, 2010 |
NCT03667365 | Terminated | N/A | Randomized Study for the Optimal Treatment of Symptomatic Patients With Low Gradient Severe Aortic Valve Stenosis and Preserved Left Ventricular Ejection Fraction | March 19, 2019 | November 16, 2021 |
NCT02766075 | Terminated | N/A | A STEP for Patients Prior to Undergoing TAVR: A Pilot Study | May 2016 | February 2018 |
NCT00986193 | Terminated | N/A | Transapical Transcatheter Treatment Versus Conventional Surgery in Patients With Native Aortic Valve Stenosis | December 2008 | April 2016 |
NCT00269165 | Terminated | Phase 3 | Adjuvant Radiation in Aortic Valvuloplasty - ARAVA | November 2005 | |
NCT01504737 | Terminated | N/A | Rehabilitation in Aortic Stenosis Patients | September 2011 | September 1, 2017 |
NCT04639258 | Terminated | N/A | Medtronic Evolut™ EXPAND TAVR I Feasibility Study | May 28, 2021 | June 7, 2022 |
NCT02799823 | Terminated | N/A | Transfemoral Replacement of Aortic Valve With HLT MeriDIAN Valve Early Feasibility Trial | April 27, 2017 | January 20, 2023 |
NCT01810679 | Terminated | N/A | Perceval S Aortic Heart Valve Study- North America | April 2013 | April 2018 |
NCT03308435 | Terminated | Effect of TF-TAVR on Emotional Status, Quality of Life, Frailty and Inflammation | November 6, 2017 | December 31, 2020 | |
NCT01939678 | Terminated | Characterization and Role of Mutations in Sodium-phosphate Cotransporters in Patients With Calcific Aortic Valve Disease | September 2013 | September 2019 | |
NCT02818959 | Terminated | N/A | First in Man Study of the JenaValve TAVI Plus System Transfemoral | December 2013 | May 2015 |
NCT01636648 | Terminated | Enable I Long-term Follow-up Study | August 2012 | April 2016 | |
NCT04008550 | Terminated | N/A | Prognostic Impact of the Evolution of PAH 3 Months After TAVI (HTP-TAVI) | March 6, 2019 | March 5, 2020 |
NCT04009720 | Terminated | RESPOND EDGE Post Market Study | October 11, 2019 | June 2, 2021 | |
NCT00404287 | Terminated | Phase 4 | Randomized Study to Evaluate the Efficacy of Fluvastatin on Inflammatory Markers in Patients With Aortic Stenosis. | October 1, 2006 | January 2018 |
NCT03618095 | Terminated | N/A | REPRISE IV: LOTUS Edge Valve System in Intermediate Surgical Risk Subjects | January 14, 2019 | March 31, 2021 |
NCT02007967 | Terminated | Non-Contrast Magnetic Resonance Angiography Assessment of Patients Referred for Transcatheter Aortic Valve Implantation | December 2013 | January 2014 | |
NCT02854319 | Terminated | N/A | REpositionable Percutaneous Replacement of NatIve StEnotic Aortic Valve Through Implantation of LOTUS EDGE Valve System | September 7, 2016 | March 13, 2018 |
NCT00598598 | Terminated | Echocardiographic Assessment of Cardiovascular Changes in Long Term Space Flight | October 2003 | July 2008 | |
NCT00538759 | Terminated | Phase 2/Phase 3 | Radiation Following Percutaneous Balloon Aortic Valvuloplasty to Prevent Restenosis | September 2007 | July 2010 |
NCT03810820 | Unknown status | N/A | Remote ECG Monitoring of TAVI Patients | June 20, 2018 | July 30, 2021 |
NCT03881527 | Unknown status | N/A | Nitinol Circular Blade | October 2015 | December 2019 |
NCT03665389 | Unknown status | N/A | Evaluation of Fractional Flow Reserve Calculated by Computed Tomography Coronary Angiography in Patients Undergoing TAVR | September 13, 2018 | March 31, 2022 |
NCT03649594 | Unknown status | Risk Stratification Post TAVI Using TEG | October 1, 2020 | April 30, 2023 | |
NCT03633383 | Unknown status | Outcomes of Transcatheter Aortic Valve Implantation in Management of Severe Symptomatic Aortic Stenosis | August 31, 2018 | January 2021 | |
NCT00699452 | Unknown status | Phase 3 | The Potential of Candesartan to Retard the Progression of Aortic Stenosis | May 2009 | December 2014 |
NCT03621709 | Unknown status | CoreValve™ Evolut R™ 34 mm System Registry (CoreValve34) | August 1, 2017 | September 2020 | |
NCT04056832 | Unknown status | N/A | Left Ventricular Reverse Remodeling In Aortic Valve Replacement With Single Strip Pericardium Versus Mechanical Valve | April 20, 2017 | April 20, 2020 |
NCT03600935 | Unknown status | N/A | Safety and Feasibility of Early Discharge for Transfemoral Transcatheter Aortic Valve Replacement | October 2018 | September 2021 |
NCT03574311 | Unknown status | Phase 4 | Preoperative Intravenous Ferric Carboxymaltose and Placebo in the Treatment of Patients Undergoing Cardiac Surgery | October 2, 2018 | December 2023 |
NCT03549559 | Unknown status | N/A | Imaging Histone Deacetylase in the Heart | September 7, 2018 | July 1, 2023 |
NCT03385785 | Unknown status | Ventriculo-arterial Coupling Modification Evaluated by PRAM During TAVI Procedure | September 14, 2017 | November 1, 2018 | |
NCT00294775 | Unknown status | Phase 3 | Effect of Angiotensin II Receptor Blockers (ARB) on Left Ventricular Reverse Remodelling After Aortic Valve Replacement in Severe Valvular Aortic Stenosis | February 2006 | June 2009 |
NCT03361046 | Unknown status | Polish Transcatheter Aortic Valve-in-Valve Implantation (ViV-TAVI) Registry | January 1, 2018 | May 30, 2024 | |
NCT03361007 | Unknown status | Polish Registry of Common Carotid Artery Access for TAVI | January 1, 2018 | May 30, 2024 | |
NCT04307888 | Unknown status | Spanish Percutaneous Aortic INtervention REGISTRY (SPAIN REGISTRY) | April 2020 | March 2022 | |
NCT00222950 | Unknown status | Concentration of Plant Sterols in Serum and Aortic Valve Cusps | September 2003 | September 2005 | |
NCT04335149 | Unknown status | Follow-up After TAVR Without Systematic Intensive Care Unit Admission | January 1, 2017 | December 1, 2022 | |
NCT03051360 | Unknown status | Phase 2 | PCSK9 Inhibitors in the Progression of Aortic Stenosis | June 1, 2017 | January 1, 2020 |
NCT03051334 | Unknown status | Ascending Aortic Dilation in BiAV After TAVR | January 1, 2007 | December 30, 2017 | |
NCT04392492 | Unknown status | Vascular Closure Device in Transcatheter Aortic Valve Replacement | January 25, 2017 | January 31, 2021 | |
NCT03001960 | Unknown status | Phase 3 | Dual AntiPlatelet Therapies for Prevention of Periinterventional Embolic Events in TAVI | March 2017 | April 2018 |
NCT01932099 | Unknown status | Phase 2 | TranScatheter Aortic Valve RepLacement System US Feasibility Trial | August 2013 | December 2018 |
NCT04429035 | Unknown status | N/A | SLOW-Slower Progress of caLcificatiOn With Vitamin K2 | September 23, 2019 | December 23, 2023 |
NCT02917525 | Unknown status | Phase 2 | Bicuspid Aortic Valve Stenosis and the Effect of vItamin K2 on Calciummetabolism on 18F-NaF PET/MRI | August 2016 | December 2019 |
NCT02019797 | Unknown status | Phase 4 | Desflurane-induced Myocardial Protection | January 2014 | December 2016 |
NCT02444104 | Unknown status | Non-invasive Blood Pressure and Cardiac Output Measurement by Using Applanation Tonometry | June 2015 | December 2016 | |
NCT01822964 | Unknown status | N/A | Oxygenation of the Cerebrum and Cooling During Transcatheter Aortic Valve Implantation (TAVI) Procedures - Part II | March 2013 | December 2014 |
NCT05015829 | Unknown status | Diagnostic Impact of Low-dose Dobutamine Echocardiography in Low-flow Low-gradient Aortic Stenosis | September 1, 2019 | August 31, 2022 | |
NCT02288871 | Unknown status | N/A | Pilot Trial: Comparison of Flow Patterns | October 2014 | December 2021 |
NCT05065697 | Unknown status | Brain Lesions After Transcatheter Aortic Valve Replacement | January 2022 | January 2024 | |
NCT01707927 | Unknown status | Comparison of Two Biological Aortic Valves. Mosaic Ultra and Trifecta. | September 2012 | December 2022 | |
NCT02221921 | Unknown status | N/A | Safety and Efficacy Study of MicroPort's Transcatheter Aortic Valve and Delivery System for TAVI | September 2014 | September 2021 |
NCT00767013 | Unknown status | N/A | Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease | May 2007 | |
NCT01683474 | Unknown status | N/A | Safety and Performance of TAVI of Venus MedTech Aortic Valve Prosthesis | September 2012 | April 2016 |
NCT02195102 | Unknown status | The Asian Pacific TAVR Multicenter Registry | December 2014 | December 2021 | |
NCT01679431 | Unknown status | Metabolic Determinants of the Progression of Aortic Stenosis | April 2005 | January 2024 | |
NCT05235529 | Unknown status | Neuropsychological and Neuroimaging Evaluation of the Cognitive Impairment in Aortic Valve Replacement (ARTiCO) | January 4, 2021 | December 2023 | |
NCT02163850 | Unknown status | N/A | Transcatheter Aortic Valve Replacement System Pivotal Trial | June 2015 | December 2021 |
NCT02080299 | Unknown status | Phase 2 | Protection by Remote Ischemic Preconditioning During Transcatheter Aortic Valve Implantation | September 2013 | August 2017 |
NCT05256758 | Unknown status | N/A | Oxford - Fibrates in Aortic Stenosis | May 29, 2019 | March 31, 2022 |
NCT05272020 | Unknown status | N/A | Outcome, Recuperation and Hemodynamics in Aortic Stenosis | March 22, 2021 | March 31, 2024 |
NCT00710775 | Unknown status | N/A | Heart Leaflet Technologies Valve Study | November 2007 | December 2008 |
NCT00176410 | Unknown status | Phase 2 | Statin Therapy in Asymptomatic Aortic Stenosis | January 2003 | December 2009 |
NCT05308888 | Unknown status | Phase 2 | Impact of Local Tissue Inflammation on Intramyocardial Conduction Pathways Post Percutaneous Valve : Evaluation by Positron Emission Tomography on Exploratory Cohort | May 1, 2022 | May 1, 2024 |
NCT05374733 | Unknown status | N/A | Coronary Physiology Peri-Transcatheter Left-sided Valvular Interventions | March 22, 2021 | March 1, 2023 |
NCT01475799 | Unknown status | N/A | Percutaneous Aortic Valve 18F System for the Treatment of Patients With Severe Aortic Stenosis | November 2011 | July 2019 |
NCT01201070 | Unknown status | Phase 4 | Study of Administration Of Antithrombin in Patients With Low Plasmatic Levels of Antithrombin After Cardiac Surgery | September 2009 | November 2011 |
NCT05422170 | Unknown status | HEParin Antagonisation in Transcatheter Aortic Valve Implantation | July 1, 2022 | April 1, 2023 | |
NCT01165827 | Unknown status | German Aortic Valve Registry | July 2010 | December 2022 | |
NCT02623907 | Unknown status | China Valve Registry Study-1 | May 2016 | May 2020 | |
NCT04717219 | Unknown status | Myeloid Cells in Aortic Valve Stenosis | November 19, 2020 | December 31, 2022 | |
NCT02608567 | Unknown status | Prognostic Impact of Myocardial Longitudinal Strain in Asymptomatic Aortic Stenosis: a Meta-Analysis | October 2015 | December 2017 | |
NCT02541877 | Unknown status | Phase 3 | Sizing-sTrategy of Bicuspid AoRtic Valve Stenosis With Transcatheter Self-expandable Valve | September 2015 | September 2023 |
NCT00811330 | Unknown status | Phase 3 | Effects of High Dose Atorvastatin in Patients With Surgical Aortic Stenosis | December 2008 | January 2018 |
NCT02536703 | Unknown status | Phase 3 | Safety and Efficacy of Lotus Valve For TAVI In Patients With Severe Aortic Stenosis In Chinese Population | September 2015 | December 2020 |
NCT02498639 | Unknown status | Phase 4 | The Pacing vs No Pacing Study - PNP Study | April 2015 | January 2016 |
NCT02468219 | Unknown status | N/A | Cardiovascular Rehabilitation in Patients With Severe Aortic Stenosis Submitted to Valvar Correction | August 2020 | July 2022 |
NCT01835028 | Unknown status | Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis (TOPAS Study) | June 2002 | January 2024 | |
NCT01845285 | Unknown status | A Registry to Evaluate the Direct Flow Medical Transcatheter Aortic Valve System | March 2013 | December 2019 | |
NCT04525937 | Unknown status | Racial and Economic Disparities and Unmet Needs in Patients With Severe Aortic Valvular Disease | June 4, 2018 | August 1, 2022 | |
NCT00647088 | Unknown status | Genetic of Aortic Valve Stenosis - Clinical and Therapeutic Implications | March 2008 | December 2017 | |
NCT04573049 | Unknown status | Phase 4 | The Effectiveness and Safety of Levosimendan in Patients With Severe Aortic Stenosis and Heart Failure Undergoing Transcatheter Aortic Valve Replacement | September 1, 2020 | December 30, 2022 |
NCT04600739 | Unknown status | Validation of a Novel, Non-Dimensional Approach for Estimation of Pressure Gradients in Aortic Stenosis | October 28, 2019 | June 30, 2021 | |
NCT01118442 | Unknown status | Determination of the Acute Effects of Aortic Stenosis on Coronary Artery Haemodynamics | December 2009 | December 2019 | |
NCT04632095 | Unknown status | N/A | Parasternal vs. Sternotomy Approach for Conventional Aortic Valve Replacement | March 16, 2021 | November 15, 2022 |
NCT02713932 | Unknown status | The Italian Society of Invasive Cardiology Registry on Percutaneous Aortic Valve | July 2010 | ||
NCT02711540 | Unknown status | Retrospective Analysis of Procedural Aspects of Transcatheter Aortic Valve Implantation (TAVI) on Peri-procedural Stroke | February 2016 | July 2016 | |
NCT02650388 | Unknown status | Phase 4 | Frailty and Cognitive Function Assessment of TAVI Patients | November 2015 | October 2018 |
NCT04655742 | Unknown status | N/A | VitaFlow™ Transcatheter Aortic Valve System Pre-market Trial | June 27, 2014 | December 31, 2021 |
NCT02627391 | Unknown status | N/A | Early Surgery for Patients With Asymptomatic Aortic Stenosis | January 2016 | November 2019 |
NCT04694859 | Unknown status | Romanian National Registry of Outcomes After Transcatheter Aortic Valve Implantation in Patients With Severe Aortic Stenosis - RO-TAVI | January 5, 2021 | July 30, 2023 | |
NCT01905852 | Withdrawn | Use of Cardiac-MRI to Predict Results for People With Severe Aortic Stenosis | June 27, 2013 | December 31, 2016 | |
NCT05481814 | Withdrawn | CPX in Paradoxical Low Flow Aortic Stenosis | September 30, 2017 | July 1, 2022 | |
NCT02855099 | Withdrawn | N/A | Can Rehabilitation After TAVI Precipitate Recovery and Improve Prognosis | August 1, 2016 | July 24, 2017 |
NCT02964962 | Withdrawn | N/A | REPRISE EDGE 29 mm EU Study | April 1, 2018 | December 30, 2018 |
NCT00598754 | Withdrawn | Diagnostic Three Dimensional Echocardiography Study Protocol | June 2001 | July 2008 | |
NCT02838199 | Withdrawn | Phase 4 | TRANscatheter or SurgIcal Aortic Valve ReplacemenT in All-Comers With Severe Aortic Valve Stenosis | December 2016 | December 2030 |
NCT03928639 | Withdrawn | Structural Heart and Valve Network PROSPECTIVE Registry | January 10, 2023 | January 10, 2023 | |
NCT04363294 | Withdrawn | N/A | Targeted Testing for ATTR Among Aortic Stenosis Patients-Pilot | March 2022 | August 2023 |
NCT03315832 | Withdrawn | Phase 2/Phase 3 | Efficacy of Angiotensin Receptor Blocker Following aortIc Valve Intervention for Aortic STenOsis: a Randomized mulTi-cEntric Double-blind Phase II Study | January 2, 2023 | July 2, 2025 |
- Disase is a (Disease Ontology)
- DOID:62
- Cross Reference ID (Disease Ontology)
- GARD:5830
- Cross Reference ID (Disease Ontology)
- ICD10CM:I06.0
- Cross Reference ID (Disease Ontology)
- ICD10CM:Q23.0
- Cross Reference ID (Disease Ontology)
- ICD9CM:395.0
- Cross Reference ID (Disease Ontology)
- ICD9CM:746.3
- Cross Reference ID (Disease Ontology)
- MESH:D001024
- Cross Reference ID (Disease Ontology)
- NCI:C50462
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:155282009
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:18546004
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:60573004
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0003507
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0152417
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0155567
- Exact Synonym (Disease Ontology)
- Aortic stenosis
- Exact Synonym (Disease Ontology)
- Rheumatic aortic stenosis
- Exact Synonym (Disease Ontology)
- rheumatic aortic valve stenosis
- HPO alt_id (Human Phenotype Ontology)
- HP:0005140
- HPO Human Phenotype ID (Human Phenotype Ontology)
- HP:0001650
- MeSH unique ID (MeSH (Medical Subject Headings))
- D001024