aortic valve disease

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Information
Disease name
aortic valve disease
Disease ID
DOID:62
Description
"A heart valve disease that is located_in the aortic valve." [url:https\://www.mayoclinic.org/diseases-conditions/aortic-valve-disease/symptoms-causes/syc-20355117]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
NCT ID Status Phase Summary Start date Completion date
NCT03444259 Active, not recruiting Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients February 1, 2016 December 31, 2029
NCT05082454 Active, not recruiting Post Market Clinical Follow-Up Study in Patients Treated With the On-X Ascending Aortic Prosthesis (AAP) October 20, 2021 March 31, 2029
NCT02673931 Active, not recruiting N/A GLP-1 and Hyperoxia for Organ Protection in Heart Surgery February 2016 January 2024
NCT05411055 Active, not recruiting Aortic Valve Neocuspidization With Glutaraldehyde-Treated Autologous Pericardium (Ozaki Procedure) June 6, 2021 June 6, 2027
NCT04415047 Active, not recruiting N/A The JenaValve ALIGN-AR Pivotal Trial May 22, 2020 August 2028
NCT05330468 Active, not recruiting Regent China Post-Market Clinical Follow-up Study March 29, 2022 August 31, 2028
NCT03365453 Active, not recruiting N/A Frailty in Elderly Patients Receiving Surgical or Percutaneous Procedures for Valvular Disorders December 1, 2017 December 31, 2027
NCT03851068 Active, not recruiting N/A Early Feasibility Study for the Foldax Tria Aortic Heart Valve June 18, 2019 December 2026
NCT03481387 Active, not recruiting N/A PERCEVAL S Valve Clinical Study for Chinese Registration January 26, 2018 February 25, 2024
NCT06192706 Active, not recruiting N/A Clinical Investigation for the Foldax Tria Aortic Heart Valve- India January 1, 2022 September 1, 2024
NCT04950192 Active, not recruiting Philips Intracardiac Echocardiography (ICE) Clinical Registry October 25, 2021 July 30, 2024
NCT06235424 Active, not recruiting Phase 4 Del Nido Versus HTK Cardioplegia in Adult Aortic Valve Replacement October 1, 2018 September 24, 2024
NCT03924661 Active, not recruiting SJM Masters HP 15mm Rotatable Mechanical Heart Valve as Aortic Valve Replacement Therapy October 24, 2019 October 2028
NCT03876964 Available J-Valve Compassionate Use
NCT05912660 Completed Health Status of Patients After Surgically Implanted Biological and TAVI: a Population-based Retrospective Analysis January 1, 2010 December 31, 2020
NCT00465218 Completed Transcranial Doppler (TCD) Assessment During Early Anti-thrombotic Therapy After Bioprosthetic Aortic Valve Replacement March 2007 March 2011
NCT05840757 Completed N/A Non-Invasive MOnitoring in Transcathether Aortic Valve Implantation March 31, 2023 December 31, 2023
NCT02247128 Completed Phase 4 Antiplatelet Therapy for Patients Undergoing Transcatheter Aortic Valve Implantation January 2014 April 2020
NCT02266251 Completed Optimizing Health Outcomes in Patients With Symptomatic Aortic Valve Disease May 2014 May 30, 2017
NCT02338154 Completed EDWARDS INTUITY Valve System FOUNDATION Study July 2012 April 2016
NCT02458560 Completed N/A CENTERA-2: Safety and Performance Study of the Edwards CENTERA-EU Self-Expanding Transcatheter Heart Valve March 2015 August 13, 2021
NCT02467062 Completed N/A Implementation of Non-size Markers Derived From 4D Flow MRI of Patients With Aortic Disease. September 2015 September 2016
NCT02522663 Completed N/A The Impact of 24/7-phone Support on Readmission After Aortic Valve Replacement, a Randomized Clinical Trial August 20, 2015 March 1, 2018
NCT05627973 Completed Health Status of < 50 Year Old Patients After Surgically Implanted Biological and Mechanical Aortic Valves: a Population-based Retrospective Analysis (2010-2020) January 1, 2010 December 31, 2020
NCT02640794 Completed Phase 4 Aspirin Versus Aspirin+Clopidogrel as Antithrombotic Treatment Following TAVI January 2015 March 2018
NCT02668484 Completed N/A REpositionable Versus BallOOn-expandable Prosthesis for Trans-catheter Aortic Valve Implantation January 2016 May 31, 2019
NCT02672553 Completed N/A EDWARDS INTUITY Valve System CADENCE-MIS Study May 2012 August 2015
NCT02688153 Completed N/A EDWARDS INTUITY Valve System CADENCE Study October 2012 April 2016
NCT02724709 Completed Semi-automatic assessMent of Aortic Roots by Three-dimensional transoEsophageal echocaRdiography (SMARTER) March 2016 August 2016
NCT02726087 Completed N/A Quality of Life After Ministernotomy Versus Full Sternotomy Aortic Valve Replacement March 20, 2016 October 20, 2019
NCT02806310 Completed Podocan and Wnt Pathway in the Development of Aortopathy in Bicuspid Valve Disease June 2016 December 2020
NCT02907463 Completed EDWARDS INTUITY Elite Valve System February 2016 December 2017
NCT02981004 Completed PAR I - Patient-to-Annulus Relation I October 2012 December 18, 2017
NCT03016169 Completed N/A Trifecta™ GT Post Market Clinical Follow-up March 9, 2017 August 31, 2023
NCT03025971 Completed N/A Safety & Efficacy of the J-Valve Ausper System in Patients With Severe Aortic Stenosis and/or Aortic Regurgitation March 2014 April 2020
NCT05193760 Completed Robustness Check of Placement and Measurement Algorithms for Blood Flow Measurement on Common Carotid Artery October 6, 2021 September 28, 2022
NCT04900909 Completed Health Status of Patients After Surgically Implanted Biological and Mechanical Aortic Valves: a Population-based Retrospective Analysis (2010-2018) January 1, 2010 December 31, 2018
NCT04437303 Completed Phase 4 Periprocedural Continuation Versus Interruption of Oral Anticoagulant Drugs During Transcatheter Aortic Valve Implantation (POPular PAUSE TAVI) November 25, 2020 May 22, 2024
NCT04401397 Completed N/A Effect of Early Mobilization on Length of Stay, Recovery and Readmission Rate of Patients After CABG or AVR/MVR Surgery June 3, 2020 December 23, 2020
NCT00665301 Completed Cardiac Output Pulmonary Arterial Catheter Compared to FloWave™ 1000 March 2008 June 2008
NCT06120946 Completed Neurocognitive Assessment in TAVI May 18, 2021 December 13, 2022
NCT00883285 Completed Incidence and Severity of Silent and Apparent Cerebral Embolism After Conventional and Minimal-invasive Transfemoral Aortic Valve Replacement April 2009 December 2013
NCT01293188 Completed Observatory of Anticoagulation After Bioprosthetic Aortic Valve Replacement January 2011 June 2014
NCT01383720 Completed N/A REpositionable Percutaneous Replacement of Stenotic Aortic Valve Through Implantation of Lotus™ Valve SystEm April 2012 May 9, 2017
NCT01559298 Completed Phase 4 Aspirin Versus Aspirin + ClopidogRel Following Transcatheter Aortic Valve Implantation: the ARTE Trial March 2012 March 2016
NCT01808274 Completed N/A Safety and Performance Study of the Edwards CENTERA Self-Expanding Transcatheter Heart Valve February 1, 2013 August 23, 2018
NCT01808287 Completed N/A Safety and Performance Study of the Edwards SAPIEN 3 Transcatheter Heart Valve/ The SAPIEN 3 Study January 2013 December 17, 2019
NCT02000544 Completed N/A Clinical Evaluation of a Modular Extracorporeal Circulation Circuit October 2013 December 2020
NCT02031796 Completed N/A Cardiac Vascular Reconstruction DynaCT for TAVI Procedures February 2014 October 17, 2017
NCT02098772 Completed Phase 3 Phase III Study Comparing Two Methods of Cardioplegia in Aortic Valve Surgery Custodiol-N Versus Custodiol May 2014 December 2018
NCT03807921 Completed Phase 4 Anticoagulation for Aortic Bioprosthesis (ANTIPRO) January 1, 2019 December 31, 2019
NCT03818126 Completed N/A The Del Nido Versus Cold Blood Cardioplegia in Aortic Valve Replacement July 1, 2016 July 31, 2018
NCT04455165 Completed Factors Influencing Morbi-mortality in Right Anterior Minithoracotomy Approch for Aortic Valve Replacement June 29, 2020 June 29, 2020
NCT04897659 Completed Left Bundle Branch Block (LBBB) After IntuityTM January 1, 2021 May 1, 2021
NCT03894787 Completed Ross for Valve Replacement in Adults - Registry June 3, 2019 December 22, 2023
NCT03976817 Completed Aortic Valve Replacement Above the Aortic Annulus (SA-AVR) With the Carpentier-Edwards Magna-Ease Bioprosthesis February 1, 2018 April 1, 2019
NCT04557345 Completed Evaluation of the Inflammatory Response in Post-operated Aortic Valve Replacement Patients. January 1, 1990 August 1, 2020
NCT04073875 Completed 18F-GP1 PET-CT to Detect Bioprosthetic Aortic Valve Thrombosis October 22, 2019 October 13, 2021
NCT04086836 Completed Swedish Study on STroke After TAVR July 1, 2019 February 1, 2020
NCT04491513 Completed Detection of Proximal Coronary Artery Disease in the Work-up for Transcatheter Aortic Valve Implantation Using CTA (From the DEPICT CTA Database) October 1, 2019 July 1, 2020
NCT03130491 Completed N/A European Study Evaluating the EMBLOK Embolic Protection System During TAVR March 8, 2017 January 28, 2022
NCT03135496 Completed Evaluation of Endothelial Dysfunction During Aortic Valvular Replacement by Bioprosthesis With and Without Extracorporeal Circulation January 5, 2017 January 4, 2019
NCT05082337 Completed N/A The SAVVY Guidewire in Transcatheter Aortic Valve Replacement Procedures October 8, 2021 December 28, 2021
NCT03223558 Completed N/A Early Initiation of Post Sternotomy CArdiac Rehabilitation July 10, 2017 August 5, 2020
NCT03239262 Completed N/A Left Atrial Cryoablation Enhanced by Ganglionated Plexi Ablation in the Treatment of Atrial Fibrillation July 1, 2012 February 28, 2016
NCT04909424 Completed Prevalence of Cutaneous Enterococci at Femoral Insertion Site in Transcatheter Aortic Valve Implantation (TAVI) June 17, 2021 November 23, 2023
NCT00486928 Completed Twenty-five-year Experience With the Medtronic-Hall Valve Prosthesis May 2004 May 2005
NCT00257777 Completed N/A Intermittent Cold Blood vs Crystalloid Cardioplegia in Aortic Valve Surgery November 2003 November 2007
NCT03677804 Completed Aortic Valve Reconstruction Using Autologous Pericardium: Single Center Experience With the Ozaki Technique August 2, 2017 June 12, 2019
NCT03796442 Completed N/A Comparison of Two Pericardial Bioprostheses in AVR January 23, 2019 May 31, 2022
NCT03798782 Completed N/A Ross for Valve Replacement in AduLts Trial April 29, 2019 December 22, 2023
NCT05979870 Enrolling by invitation Artificial Intelligence in New Cardiac MR Markers for Congenital Heart Disease October 1, 2022 December 31, 2028
NCT04430972 Not yet recruiting Immune Responsiveness and Outcome After Aortic Valve Surgery (Measure) September 2023 September 2026
NCT05975567 Not yet recruiting Deploying Novel Imaging Modalities Towards a Three-dimensional (3D) CARDIOvascular PATHology September 1, 2023 June 1, 2025
NCT03163329 Not yet recruiting Phase 2 The Safety and Effectiveness of Transcatheter Aortic Valve Raplacemet in Intermediate Risk Patients With Bicuspid Aortic Stenosis February 1, 2018 October 31, 2024
NCT06011148 Not yet recruiting Clinical Data Collection on Perceval S Sutureless Prosthetic Aortic Valve in the Chinese Population December 2024 December 2025
NCT05977257 Not yet recruiting VitaFlow® Transcatheter Aortic Valve Replacement System Pre-market Trial Long Term Follow Up (VITAL) July 30, 2023 October 30, 2028
NCT06112561 Not yet recruiting N/A Cardiac Index, SVR/SVRI During Weaning From ECC- Data Obtained From Femoral and Radial Artery Transducer January 2024 May 2024
NCT05687448 Not yet recruiting Phase 4 DIrect Oral Anticoagulation and mechaNical Aortic Valve March 2023 November 2026
NCT05536310 Not yet recruiting TAVIS Registry - Trilogy Heart Valve System for Management of Patients With Aortic Valve Disease March 2023 October 2027
NCT05941455 Not yet recruiting N/A A Prospective Multicenter Pivotal Study to Evaluate Safety and Effectiveness of Venus-Neo Surgical Aortic Valve October 31, 2023 October 31, 2029
NCT06286358 Recruiting Aortopathy Relationship To Imagery and Kinocardiography Features (ARTIK) March 7, 2024 September 30, 2025
NCT02153307 Recruiting N/A Ambulatory Electrocardiographic Monitoring for the Detection of High-Degree Atrio-Ventricular Block in Patients With New-onset PeRsistent LEft Bundle Branch Block After Transcatheter Aortic Valve Implantation. The "MARE" Study January 2014 July 2024
NCT03440697 Recruiting Pathogenetic Basis of Aortopathy and Aortic Valve Disease December 10, 2015 December 31, 2030
NCT03453567 Recruiting Evaluation of Effectiveness and Safety of Aortic Valve Replacement in Routine Clinical Practice May 10, 2018 December 15, 2030
NCT04149600 Recruiting Identification of Genetic Causes of Calcific Aortic Valve Disease September 25, 2018 June 30, 2027
NCT04754217 Recruiting Valved Graft PMCF Study July 13, 2021 September 2029
NCT04864145 Recruiting N/A Transcatheter Self-expandable Valve Implantation for the Treatment of Severe Native Aortic Regurgitation May 21, 2021 May 30, 2031
NCT05076604 Recruiting Phase 4 Effects of Microplegia on Transfusion Rates After Cardiac Surgery March 25, 2019 August 1, 2023
NCT05093764 Recruiting N/A Quantification of Debris Captured Using TCEP During VIV TAVR With BVF March 2, 2022 December 31, 2025
NCT05162742 Recruiting Phase 3 Colchicine and Inflammation in Aortic Stenosis December 22, 2022 December 22, 2025
NCT05217888 Recruiting The Sentinel Registry May 18, 2022 April 30, 2024
NCT05295628 Recruiting N/A Evaluation of Safety and Effectiveness of the EMBLOK EPS During TAVR October 17, 2023 February 1, 2025
NCT05389631 Recruiting Trifecta and Epic ViV Detailed Insights Into Management Strategies and Outcomes August 17, 2022 December 31, 2023
NCT05391191 Recruiting N/A Safety and Feasibility of TRISKELE in Severe AS July 6, 2022 March 31, 2023
NCT05439863 Recruiting TAVR for Aortic Valve Disease July 1, 2022 December 30, 2037
NCT05484713 Recruiting Feasibility of 3D Printed Models of Aortic Stenosis in Guiding TAVI Procedure July 8, 2022 July 2023
NCT05620875 Recruiting The Association Between Delivered Oxygen and Cerebral Impact During the Use of Cardiopulmonary Bypass. January 2, 2023 November 2024
NCT05635227 Recruiting N/A Dexamethasone, Olanzapine, Hemodynamics, and Ventilation in Cardiac Surgery November 10, 2022 December 2027
NCT05670041 Recruiting N/A Re-hospitalisation After Transcatheter Aortic Valve Implantation January 16, 2023 March 16, 2025
NCT05758909 Recruiting Evaluation of the Viability and Safety of Early Discharge Protocol After TAVI Implantation April 4, 2023 December 1, 2025
NCT05932615 Recruiting N/A ENVISION IDE Trial: Safety and Effectiveness of NAVITOR in Transcatheter Aortic Valve Implantation March 19, 2024 April 2036
NCT05961150 Recruiting PROMISE: Percutaneous peRipheral cannulatiOn for Minimally-InvaSive Heart Valve surgEry August 1, 2023 December 2024
NCT05998694 Recruiting Post-market Clinical Monitoring of the Safety and Efficacy of the Aortic Valve Bioprothesis June 1, 2021 August 10, 2024
NCT06001489 Recruiting N/A The Effects of 360-degree Virtual Reality on Pre-procedural Anxiety in Patients Awaiting Elective Cardiac Surgery Involving a Sternotomy September 2023 December 2024
NCT06025149 Recruiting The Study on the Use of "UniLine" Bioprosthesis in the Treatment of Isolated Aortic and Mitral Valve Diseases September 1, 2018 January 31, 2035
NCT06034028 Recruiting N/A J-Valve TF Early Feasibility Study October 16, 2023 June 25, 2029
NCT06069232 Recruiting Aortic Valve Diseases RISk facTOr assessmenT and Prognosis modeL Construction March 1, 2021 March 1, 2028
NCT06106451 Recruiting N/A Optimization Post-TAVR to IMprove Activity Levels (OPTIMAL Study) January 29, 2024 April 1, 2027
NCT06119607 Recruiting N/A PILot Aortic Triflo Valve Study November 30, 2023 May 2029
NCT06126367 Recruiting Assessment of Lipoprotein(a) and Endogenous Fibrinolysis in Atherosclerotic Cardiovascular Disease/Aortic Valve Disease October 20, 2023 October 1, 2027
NCT06136689 Recruiting Role of Aortic Valve Composition in Pathophysiology and Diagnosis of Aortic Stenosis January 1, 2022 May 1, 2025
NCT06189976 Recruiting N/A Rapid Atrial Pacing After TAVI to Predict Pacemaker Implantation March 1, 2024 December 31, 2025
NCT06197321 Recruiting Non-invasive Prediction of Fluid and Noradrenaline Responsiveness Using the Carotid Wave Intensity. January 15, 2024 December 31, 2024
NCT06235385 Recruiting European Association of Cardiovascular Imaging Multiple and Mixed Valvular Disease Study February 7, 2024 August 1, 2029
NCT06275100 Recruiting N/A PREhabilitation in Patients Awaiting Acute Inpatient Cardiac SurgEry April 3, 2024 June 2025
NCT02679404 Terminated Sorin Universal REgistry on Aortic Valve Replacement May 2015 March 2021
NCT01281397 Terminated Bleeding Prediction in Patients Following Cardiac Surgery Using Whole Blood Aggregometry and Thromboelastometry August 2009 January 2011
NCT01256710 Terminated Trifecta™ Durability Study January 2011 March 12, 2021
NCT02673697 Terminated N/A Perceval Sutureless Implant Versus Standard-Aortic Valve Replacement March 22, 2016 July 31, 2020
NCT00619151 Terminated N/A CarboMedics Top Hat vs St. Jude Medical Regent Valve Comparing Sizing and Hemodynamics December 2007 May 2008
NCT04142658 Terminated Phase 3 PROACT Xa - A Trial to Determine if Participants With an On-X Aortic Valve Can be Maintained Safely on Apixaban May 1, 2020 December 12, 2022
NCT03879824 Terminated N/A Radial Versus Femoral Secondary Access During TAVI May 30, 2019 January 20, 2021
NCT00590889 Terminated N/A Artificial Valve Endocarditis Reduction Trial July 1998 September 2014
NCT02128841 Terminated Phase 2 Comparison of Antithrombotic Treatments After Aortic Valve Replacement. Rivaroxaban: A New Antithrombotic Treatment for Patients With Mechanical Prosthetic Aortic Heart Valve. September 2012 September 2017
NCT00705913 Terminated N/A Randomized Sizing and Hemodynamic Study Mitroflow vs. Magna June 2008 September 2011
NCT02694016 Terminated N/A Remote Ischemic Preconditioning in Patients Undergoing Isolated Aortic Valve Replacement Surgery February 2016 December 2017
NCT01631188 Terminated N/A Use of Transvenous Pacing Wire During Minimally Invasive Port Access Aortic Valve Surgery December 2011 December 2015
NCT05167539 Unknown status Aortic Root Enlargement Versus Aortic Root Replacement in the Management of Cases With Small Aortic Root February 10, 2022 February 1, 2024
NCT04223713 Unknown status N/A 4D- Flow- MRI After Aortic Valve Surgery January 14, 2020 August 2021
NCT04525339 Unknown status Early Outcomes of Concomitant Transcatheter Aortic Valve Implantation and Off-pump Coronary Artery Bypass Grafting in Management of Severe Symptomatic Aortic Stenosis and Coronary Artery Disease July 1, 2020 August 2021
NCT04647864 Unknown status The Coronary AccEss After Tavi Registry - A Multicenter Prospective Registry for the Coronary Access After TAVI January 28, 2021 December 1, 2022
NCT04659655 Unknown status N/A VIenna Pilot Study for Automated Annular Suturing Technology January 1, 2021 March 1, 2022
NCT04717219 Unknown status Myeloid Cells in Aortic Valve Stenosis November 19, 2020 December 31, 2022
NCT01194362 Unknown status A Study to Identify Differences in Gene Expression in Patients With Bicuspid and Tricuspid Valve Disease September 2010 December 2022
NCT04816851 Unknown status Aortic Valve Leaflets Reconstruction (Ozaki Procedure) in Aortic Valve Diseases March 30, 2021 July 30, 2023
NCT02591940 Unknown status Proof of Concept of Model Based Cardiovascular Prediction November 2013 December 2016
NCT03049995 Unknown status Stress Echo 2020 - The International Stress Echo Study November 2016 December 2021
NCT03859102 Unknown status N/A Enhanced Recovery After Cardiac Surgery December 17, 2018 November 29, 2019
NCT03323619 Unknown status Impact of Anesthesia Technique on Post-operative Delirium After Transcatheter Aortic Valve Implantation November 2, 2017 November 2, 2020
NCT03305536 Unknown status Phase 2 Decalcification of the Aortic Valve by Vitamin K2 (Menaquinone-7) January 2, 2018 December 2020
NCT05044377 Unknown status Study on Optimal Treatment Strategy for Elderly Patients With High-risk Complex Aortic Valve Disease July 1, 2021 December 31, 2022
NCT00677638 Unknown status N/A Transapical Implantation of Ventor Embracer™ Valve in Patients With Severe Aortic Valve Disease June 2008 December 2014
NCT03172338 Unknown status SMART - Systems Medicine of Heart Failure June 2, 2015 February 28, 2018
NCT03121053 Unknown status Phase 4 Preventing contrAst Induced Nephropathy After TranscathEter Aortic Valve Replacement October 2016 January 2019
NCT02221921 Unknown status N/A Safety and Efficacy Study of MicroPort's Transcatheter Aortic Valve and Delivery System for TAVI September 2014 September 2021
NCT02623907 Unknown status China Valve Registry Study-1 May 2016 May 2020
NCT00708409 Unknown status Long-Term Follow-up After the Autograft Aortic Valve Procedure (Ross Operation) January 2001 December 2011
NCT04359030 Unknown status Freestyle-Perimount Calcification Comparison November 15, 2021 October 1, 2022
NCT04307888 Unknown status Spanish Percutaneous Aortic INtervention REGISTRY (SPAIN REGISTRY) April 2020 March 2022
NCT04277572 Unknown status Outcomes of Surgery of Aortic Valve March 1, 2020 December 31, 2022
NCT04024566 Withdrawn Rapid Non-invasive Detection of Aortic Stenosis August 14, 2019 July 18, 2022
NCT01849757 Withdrawn N/A Comparison of Priming Constituents in Patients Undergoing CPB Assisted Cardiac Surgery: HES 130/0.4 or Albumin 5% November 2013 November 2017
Disase is a (Disease Ontology)
DOID:4079
Cross Reference ID (Disease Ontology)
ICD9CM:424.1
Cross Reference ID (Disease Ontology)
MESH:D000082862
Cross Reference ID (Disease Ontology)
NCI:C78650
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:8722008
Cross Reference ID (Disease Ontology)
UMLS_CUI:C1260873
OMIM Phenotype Series Number (OMIM)
PS109730