cholestasis
Information
- Disease name
- cholestasis
- Disease ID
- DOID:13580
- Description
- "A bile duct disease that is characterized by where bile cannot flow from the liver to the duodenum." [url:https\://en.wikipedia.org/wiki/Cholestasis]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT05582447 | Active, not recruiting | Osmotic Fragility in Red Blood Cells of Pediatric Patients With Cholestatic Liver Disease | April 17, 2018 | December 31, 2026 | |
| NCT06005701 | Active, not recruiting | Mallampati Score for Prediction and Prognosis of Postoperative Mortality and Morbidity and Safety Profiles of Patients Undergoing Laparoscopic Cholecystectomy in Qassim Region | January 1, 2022 | September 30, 2023 | |
| NCT02922751 | Active, not recruiting | FibroScan™ in Pediatric Cholestatic Liver Disease (FORCE) | November 16, 2016 | December 2024 | |
| NCT02778698 | Approved for marketing | Compassionate Use of Omegaven | |||
| NCT02780193 | Approved for marketing | Intravenous Fish Oils in the Treatment of Parenteral Nutrition Liver Injury | |||
| NCT01297933 | Approved for marketing | Compassionate Use of Omegaven for Pediatric Patients With Parenteral Nutrition Associated Liver Disease | |||
| NCT03072667 | Approved for marketing | Omegaven for Compassionate Use in the Treatment of Parenteral Nutrition-Associated Liver Disease | |||
| NCT02412566 | Available | SMOF Lipid for Children With Parenteral Nutrition Induced Liver Injury | |||
| NCT00392977 | Completed | Brain Manganese Deposition in High Risk Neonates | August 2006 | December 2010 | |
| NCT00512629 | Completed | Phase 1 | Cholestasis Prevention: Efficacy of IV Fish Oil | July 2007 | December 2011 |
| NCT00685386 | Completed | N/A | A Randomized Controlled Trial (RCT) of Carbon Dioxide Versus Air Insufflation During Endoscopic Retrograde Cholangiopancreatography (ERCP) | June 2008 | February 2009 |
| NCT00738101 | Completed | N/A | Compassionate Use of an Intravenous Fish Oil Emulsion in the Treatment of Liver Injury in Infants | September 2008 | March 27, 2020 |
| NCT00826020 | Completed | Phase 2 | Evaluation of Omegaven™ Parenteral Nutrition in Patients With Total Parenteral Nutrition (TPN)-Induced Cholestasis | May 1, 2009 | October 6, 2017 |
| NCT00846963 | Completed | Phase 2/Phase 3 | Ursodiol for Treating Parenteral Nutrition Associated Cholestasis in Neonates | October 2008 | March 2013 |
| NCT04604652 | Completed | Phase 2 | Open-Label Study of HTD1801 in Adult Subjects With Primary Biliary Cholangitis | May 27, 2021 | May 31, 2022 |
| NCT01073202 | Completed | N/A | Effects of Ursodeoxycholic Acid on Graft Recovery Early After Adult Liver Transplantation | May 2005 | January 2009 |
| NCT01164878 | Completed | Cholestasis in Extreme Low Birth Weight Infants (ELBW) | January 2010 | July 2010 | |
| NCT01173159 | Completed | N/A | Compassionate Use of Omegaven to Reverse Parenteral Nutrition Induced Cholestasis | July 2010 | December 2018 |
| NCT01194063 | Completed | Phase 3 | Use of Omegaven Fish Oil Emulsion for Parenteral Nutrition Associated Liver Disease in Infants and Children | October 20, 2010 | January 15, 2019 |
| NCT04510090 | Completed | Phase 1 | Evaluate the Safety, Tolerability, and PK of EP547 in Healthy Subjects and Subjects With Cholestatic or Uremic Pruritus | September 7, 2020 | July 8, 2021 |
| NCT04053023 | Completed | Phase 1 | Linerixibat and Obeticholic Acid Drug Interaction Study in Healthy Subjects | August 27, 2019 | November 25, 2019 |
| NCT03992014 | Completed | Phase 1 | Pharmacokinetics (PKs) and Metabolism of Radiolabelled Linerixibat | July 8, 2019 | August 26, 2019 |
| NCT01683240 | Completed | N/A | Prospective Multicenter Evaluation of a New Short-access-cholangioscope for Biliary Duct Strictures and Gall Stones | February 2011 | February 2016 |
| NCT03662282 | Completed | Phase 3 | Omegaven as Alternative Parenteral Fat Nutrition | October 23, 2018 | January 7, 2019 |
| NCT01879735 | Completed | Phase 1 | Biliary Excretion of Conjugated Bile Acids in Humans Measured by 11C-cholylsarcosine PET/CT | June 2013 | September 2014 |
| NCT02966834 | Completed | Phase 2 | Dose Response Study of GSK2330672 for the Treatment of Pruritus in Participants With Primary Biliary Cholangitis | January 11, 2017 | April 15, 2020 |
| NCT02357576 | Completed | Phase 3 | Standard Lipid Therapy vs IVFE Minimization for Prevention of PNALD | May 21, 2016 | November 8, 2019 |
| NCT02370251 | Completed | Phase 2/Phase 3 | Compassionate Use of Omegaven in Children | June 2015 | September 27, 2019 |
| NCT01585935 | Completed | Phase 4 | Preventing Cholestasis Using SMOFLipid® | June 2012 | November 13, 2017 |
| NCT00004410 | Completed | N/A | Randomized Study of Tauroursodeoxycholic Acid in Prophylactic Therapy of Total Parenteral Nutrition Associated Cholestasis in Infants | June 1998 | March 2002 |
| NCT00004414 | Completed | N/A | Sincalide (Cholecystokinin Octapeptide) Versus Placebo in Neonates at High Risk for Developing Parenteral Nutrition Associated Cholestasis | September 1997 | June 2002 |
| NCT00007020 | Completed | Phase 3 | Compassionate Treatment of Patients With Inborn Errors of Bile Acid Metabolism With Cholic Acid | January 1992 | December 2009 |
| NCT00007033 | Completed | N/A | Study of Magnesium Sulfate in Children With Reduced Bone Density Secondary to Chronic Cholestatic Liver Disease | October 2000 | |
| NCT00058890 | Completed | Phase 3 | Gabapentin to Treat Itch in Patients With Liver Disease | November 2000 | January 2004 |
| NCT00080236 | Completed | Phase 2 | Safety and Efficacy Study of a Caspase Inhibitor in Patients Undergoing Liver Transplantation | November 2003 | January 2006 |
| NCT00392730 | Completed | Neurodevelopment and Neuroimaging in Parenterally-fed Infants and Young Children | August 2006 | December 2010 | |
| NCT02917408 | Completed | Retrospective Study About Primary Biliary Cholangitis During January 2001 to July 2016 at West China Hospital | September 2016 | January 2017 | |
| NCT02663453 | Completed | Phase 3 | Effectiveness of Multicomponent Lipid Emulsion in Preterm Infants Requiring Parenteral Nutrition | December 2013 | January 2016 |
| NCT02801981 | Completed | Phase 1 | Dose-escalation Study of GSK2330672 in Japanese Healthy Male Volunteers | June 2016 | August 2016 |
| NCT02148146 | No longer available | Use of Omega 3 Oil Emulsion for Parenteral Nutrition Associated Cholestasis | |||
| NCT02477345 | No longer available | Compassionate Use of Omegaven IV Fat Emulsion | |||
| NCT06364969 | Not yet recruiting | Investigation of the Pruritogens of Liver-related Diseases | April 20, 2024 | August 1, 2025 | |
| NCT04167358 | Recruiting | Phase 3 | Linerixibat Long-term Safety, and Tolerability Study | July 14, 2020 | February 2, 2027 |
| NCT04309773 | Recruiting | Phase 3 | Efficacy of 24 Month of Bezafibrate in Primary Sclerosing Cholangitis With Persistent Cholestasis Despite Ursodeoxycholic Acid Therapy | April 6, 2021 | March 2025 |
| NCT05718349 | Recruiting | FGF19 in Obstructive Cholestasis: "Unveil the Signal" | January 1, 2017 | June 1, 2025 | |
| NCT02267707 | Terminated | Phase 1 | Pharmacokinetic and Safety Study of Nab®-Paclitaxel (ABI-007) Plus Gemcitabine in Subjects With Advanced Pancreatic Cancer Who Have Cholestatic Hyperbilirubinemia | May 27, 2015 | February 10, 2016 |
| NCT00816348 | Terminated | Phase 2 | Compassionate Use of Omegaven IV Fat Emulsion | December 2008 | February 2014 |
| NCT01373918 | Terminated | Phase 4 | Low Dose Fat for the Prevention of Liver Disease in Babies With Gastrointestinal Disorders | December 2010 | July 2014 |
| NCT01062815 | Terminated | N/A | Prevention of Parenteral Nutrition-Associated Cholestasis With Cyclic Parenteral Nutrition in Infants | February 2009 | June 2010 |
| NCT00969332 | Terminated | Phase 2 | A Safety and Efficacy Study to Determine if Giving Intravenous Fish Oil Helps Children With Liver Disease | August 2009 | February 12, 2019 |
| NCT02721277 | Terminated | Phase 1/Phase 2 | SMOFlipid to Lessen the Severity of Neonatal Cholestasis | May 2016 | February 2, 2017 |
| NCT02767648 | Terminated | Inter-regional Cohort of Neonatal and Infant Cholestasis in the Greater Southwest Region | May 2010 | October 2013 | |
| NCT01247012 | Unknown status | Phase 2/Phase 3 | Minimization of IntraLipid Versus Omegaven | December 2010 | December 2012 |
| NCT00135044 | Unknown status | N/A | A Trial of Taurine Supplementation in Parenteral Nutrition 1 | June 2005 | |
| NCT01252043 | Unknown status | Retrospective Review of CT and MR in Pediatric Patients With Cholestasis | October 2010 | October 2011 | |
| NCT02334293 | Unknown status | N/A | Omegaven® as Parenteral Nutrition | October 2013 | |
| NCT02936596 | Unknown status | N/A | Remission Induction of Primary Biliary Cholangitis-autoimmune Hepatitis Overlap Syndrome | December 2016 | June 1, 2022 |
| NCT01998620 | Unknown status | Phase 4 | Efficacy and Safety of S-adenosyl-L-methionine in Treatment of Chronic Hepatitis B Patients With Cholestasis | November 2013 | May 2015 |
| NCT03337074 | Unknown status | Paternally Inherited Phenotypes in Cholestasis | February 8, 2017 | April 30, 2020 | |
| NCT01739517 | Unknown status | Phase 2 | Efficacy and Safety of Omega-3 Lipid Therapy in Pediatric Patients With Parenteral Nutrition-Associated Liver Disease | March 2009 | December 2013 |
| NCT00004315 | Unknown status | Phase 2 | Phase II Pilot Study to Compare the Bioavailability of Buffered, Enteric-Coated Ursodiol With Unmodified Ursodiol for Chronic Cholestatic Liver Disease and Cystic Fibrosis-Associated Liver Disease | November 1995 | |
| NCT02420496 | Withdrawn | Phase 2 | Enteral Fish Oil is Superior to Ursodeoxycholic Acid (UDCA) and Placebo for the Treatment of Cholestasis in Infants | June 2016 | June 2016 |
- Disase is a (Disease Ontology)
- DOID:4138
- Cross Reference ID (Disease Ontology)
- ICD10CM:K83.1
- Cross Reference ID (Disease Ontology)
- ICD9CM:576.2
- Cross Reference ID (Disease Ontology)
- MESH:D002779
- Cross Reference ID (Disease Ontology)
- NCI:C83006
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:33688009
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0008370
- Exact Synonym (Disease Ontology)
- bile occlusion
- Exact Synonym (Disease Ontology)
- Obstruction of bile duct
- HPO Human Phenotype ID (Human Phenotype Ontology)
- HP:0001396
- MeSH unique ID (MeSH (Medical Subject Headings))
- D002779