Cachexia
Information
- Disease name
- Cachexia
- Disease ID
- Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT03982082 | Active, not recruiting | N/A | Ultrasound in Evaluating Muscle-Glycogen Content in Cancer Patients | April 12, 2019 | December 31, 2024 |
| NCT03606317 | Active, not recruiting | Retrospective Review of Cachexia in Lung and Gastrointestinal Cancer Patients | November 26, 2013 | March 18, 2025 | |
| NCT05546476 | Active, not recruiting | Phase 2 | Study of the Efficacy and Safety of Ponsegromab in Patients With Cancer, Cachexia and Elevated GDF-15 | November 21, 2022 | April 30, 2025 |
| NCT03191955 | Active, not recruiting | Muscle Wasting in Cancer (MWIC) | November 26, 2015 | August 1, 2025 | |
| NCT00004400 | Completed | Phase 2 | Phase II Randomized Study of Physiologic Testosterone Replacement in Premenopausal, HIV-Positive Women | April 1997 | September 2001 |
| NCT00004912 | Completed | Phase 2 | Megestrol and Exercise in Treating Patients With Cancer-Related Weight Loss | January 2000 | November 2003 |
| NCT00006799 | Completed | Phase 3 | Megestrol to Limit Weight Loss and Improve Quality of Life in Treating Patients With Head and Neck Cancer | October 1, 2000 | September 6, 2002 |
| NCT00014248 | Completed | Phase 1 | Adenosine Triphosphate in Treating Patients With Advanced Solid Tumors | October 2000 | |
| NCT00031707 | Completed | Phase 3 | Comparison of Megestrol and/or Omega-3 Fatty Acid-Enriched Nutritional Supplement in Treating Patients With Cancer-Related Weight Loss and Lack of Appetite | March 2000 | January 2004 |
| NCT00031785 | Completed | Phase 3 | Megestrol in Treating Patients Who Are Undergoing Radiation Therapy for Lung Cancer | September 1, 2000 | September 11, 2002 |
| NCT00040885 | Completed | Phase 3 | Docetaxel With or Without Infliximab in Treating Weight Loss, Loss of Appetite, and Fatigue in Patients With Unresectable Non-Small Cell Lung Cancer (Infliximab Treatment Discontinued Effective 10/05/05) | October 2002 | October 2008 |
| NCT00046904 | Completed | Phase 3 | Etanercept in Treating Cancer-Related Cachexia and Anorexia in Patients With Advanced Cancer | May 2003 | |
| NCT00053053 | Completed | Phase 3 | Comparison of Nutritional Supplements in Preventing Weight Loss in Patients With Cancer | December 2002 | February 2009 |
| NCT00060502 | Completed | Phase 2 | A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Pancreatic Cancer Related Cachexia | April 2003 | February 2006 |
| NCT00066248 | Completed | Phase 2 | Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment | June 2003 | August 2007 |
| NCT00081250 | Completed | Phase 3 | Creatine in Treating Patients With Cancer-Associated Weight Loss | December 2004 | July 2017 |
| NCT00244192 | Completed | Phase 2 | Effects of Infliximab (Remicade) on Fat Free Mass in Patients With Moderate to Severe COPD Suffering From Cachexia | October 2003 | December 2005 |
| NCT00467844 | Completed | Phase 2 | Study of GTx-024 on Muscle Wasting (Cachexia) Cancer. | May 2007 | September 2008 |
| NCT00486304 | Completed | Phase 1 | Low Antioxidant Diet in Controlling Cachexia in Patients With Oropharyngeal Cancer Receiving Chemotherapy and Radiation Therapy | February 2006 | May 2008 |
| NCT00527319 | Completed | Phase 2 | Regimen for the Treatment of Cachexia in Subjects With NSCLC | January 2007 | September 2008 |
| NCT00000737 | Completed | Phase 1 | A Phase I/II Study to Evaluate Single Agent and Combination Therapy With Megestrol Acetate and Dronabinol for the Treatment of HIV-Wasting Syndrome | ||
| NCT00002067 | Completed | Phase 3 | A Study Comparing Megestrol Acetate at 800 mg/Day, and Placebo in AIDS Patients With Anorexia and Cachexia | ||
| NCT00002300 | Completed | Phase 2 | A Study of Different Doses of Megestrol Acetate in Patients With AIDS Who Have Anorexia and Malnutrition | ||
| NCT00002345 | Completed | Phase 4 | The Safety and Effectiveness of Megace in HIV-Infected Women | ||
| NCT00698828 | Completed | Phase 2 | SUN11031 in Cachexia Associated With Chronic Obstructive Pulmonary Disease (COPD) | May 15, 2008 | October 8, 2009 |
| NCT00852020 | Completed | N/A | Safety, Tolerance and Efficacy of an Oral Nutritional Supplement in Chronic Heart Failure and Chronic Obstructive Pulmonary Disease Patients | April 2009 | April 2011 |
| NCT00866970 | Completed | Phase 2 | Safety, Efficacy and Pharmacokinetics of ALD518 in Patients With Non-Small Cell Lung Cancer-related Fatigue and Cachexia | September 2008 | December 2009 |
| NCT00878995 | Completed | Phase 1 | Testosterone for Treating Cachexia in Patients With Squamous Cell Carcinoma | June 3, 2009 | June 2015 |
| NCT00899158 | Completed | Biological Markers in Patients With Pancreatic Cancer Experiencing Weight Loss | June 2005 | December 2008 | |
| NCT00933361 | Completed | Phase 1/Phase 2 | Individual Dose-escalated Bi-daily Subcutaneously (sc) Ghrelin in Cancer Cachexia: a Phase I/II Study | June 2009 | December 2011 |
| NCT00972634 | Completed | Computerized Questionnaires in Assessing Symptoms, Pain, Depression, and Physical Function in Patients With Metastatic and/or Advanced Locoregional Cancer | October 2008 | December 2009 | |
| NCT00994669 | Completed | Development of a Non-invasive Assessment of Skeletal Muscle Loss in Cancer Patients | October 2009 | October 2012 | |
| NCT01015274 | Completed | Non-invasive Assessment of Skeletal Muscle Loss in Cancer Patients | October 2009 | ||
| NCT01387269 | Completed | Phase 3 | Safety and Efficacy of Anamorelin HCl in Patients With Non-Small Cell Lung Cancer-Cachexia (ROMANA 1) | July 2011 | February 2015 |
| NCT01387282 | Completed | Phase 3 | Safety and Efficacy of Anamorelin HCl in Patients With Non-Small Cell Lung Cancer-Cachexia (ROMANA 2) | July 2011 | February 2015 |
| NCT01395914 | Completed | Phase 3 | Anamorelin HCl in the Treatment of Non-Small Cell Lung Cancer-Cachexia (NSCLC-C): An Extension Study (ROMANA 3) | July 2011 | February 2015 |
| NCT01397214 | Completed | Phase 1 | Pharmacokinetics of Megace F and Megace OS Under Fasting and Fed Conditions in Healthy Male Volunteers | July 2011 | January 2012 |
| NCT01419145 | Completed | N/A | A Feasibility Study of Multimodal Exercise/Nutrition/Anti-inflammatory Treatment for Cachexia - the Pre-MENAC Study | October 2011 | November 2014 |
| NCT01433263 | Completed | Phase 2 | Clinical Study of BYM338 for the Treatment of Unintentional Weight Loss in Patients With Cancer of the Lung or the Pancreas | August 2011 | April 2014 |
| NCT01533909 | Completed | Development of a Screening Tool to Detect and Stage Cachectic Cancer Patients | March 2012 | September 2013 | |
| NCT01647841 | Completed | Maternal Determinants of HIV-exposed and HIV-unexposed Fetal Growth, Birth Outcomes and Early Infant Growth | April 2012 | July 2013 | |
| NCT01692990 | Completed | Early Phase 1 | Study on the Effect of Fish Oil and Appetite | October 2011 | November 2011 |
| NCT01694602 | Completed | Non-Invasive Assessment of Skeletal Muscle Loss in Cancer Patients - Phase II | November 2012 | June 2015 | |
| NCT01696604 | Completed | Phase 1 | A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GSK2849466 in Healthy Male Subjects | September 26, 2012 | May 3, 2013 |
| NCT01939340 | Completed | Prevalence of Cachexia in Patients Undergoing Chemotherapy | April 2010 | May 2013 | |
| NCT01941810 | Completed | N/A | Bovine Lactoferrin Supplement in Improving Taste in Patients With Cancer Receiving Chemotherapy | February 2014 | October 2015 |
| NCT01962454 | Completed | Phase 1 | A Study to Evaluate a Skeletal-muscle Microbiopsy Technique With Dynamic Proteomic Measurement in Healthy Male Volunteers | May 5, 2014 | March 20, 2015 |
| NCT02045940 | Completed | Phase 1 | Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study of GSK2881078 in Single and Repeat Doses | January 20, 2014 | March 26, 2015 |
| NCT02330926 | Completed | Phase 3 | Multimodal Intervention for Cachexia in Advanced Cancer Patients Undergoing Chemotherapy | April 2015 | April 2023 |
| NCT02350855 | Completed | Phase 2 | Impact of Nutritional Intervention in Indian Female Cancer Cachexia Patients | December 2013 | August 2014 |
| NCT02400398 | Completed | Evaluating Weight Stability of Pancreatic Cancer Cachexia Patients | April 27, 2015 | May 15, 2020 | |
| NCT02418546 | Completed | N/A | Electronic-health Application To Measure Outcomes REmotely Clinical Trial | April 2015 | March 2018 |
| NCT02442908 | Completed | N/A | Pilot Study of Safety and Tolerability of Nutrifriend Cachexia in COPD Cachexia | May 2015 | June 2016 |
| NCT02500004 | Completed | N/A | Brown Adipose Tissue Activity and Energy Metabolism in Cachexia | June 2015 | July 2018 |
| NCT02515032 | Completed | N/A | Pilot Study of Safety and Tolerability of Nutrifriend Cachexia in NSCLC Cachexia | July 2015 | May 2017 |
| NCT02561143 | Completed | N/A | Effectiveness of Nutritional Counselling and "Improved Atta" Supplementation in Cachexic Adult Indian Cancer Patients | April 2015 | May 2016 |
| NCT02567773 | Completed | Phase 1 | Safety, Tolerability, Pharmacokinetic (PK), and Pharmacodynamic Study of GSK2881078 and Study to Evaluate the Effect of CYP3A4 Inhibition on PK of GSK2881078 | September 2015 | December 2016 |
| NCT02968979 | Completed | Non-interventional Study to Assess the Frequency of Cachexia in Patients With Non-small Cell Lung Cancer. | July 2016 | October 2016 | |
| NCT03042442 | Completed | Relation Between Cachexia, Diabetes and periNeural Invasion in PANcreatic Cancer- Biomarkers Substudy | January 1, 2017 | September 30, 2018 | |
| NCT03162042 | Completed | Role of Myostatin, Activin A and Follistatin Cachexia of ENT Cancers | November 2, 2015 | May 2017 | |
| NCT03207724 | Completed | Phase 1 | Study of Onivyde and 5-FU in Combination With Xilonix for Pancreatic Cancer With Cachexia | October 16, 2017 | October 27, 2020 |
| NCT03359473 | Completed | Phase 2 | Study to Evaluate the Safety and Efficacy of 13 Weeks of the Selective Androgen Receptor Modulator (SARM) GSK2881078 in Chronic Obstructive Pulmonary Disease (COPD) | February 28, 2018 | November 19, 2019 |
| NCT03392116 | Completed | Phase 1 | Single and Multiple Ascending Dose Study of NGM120 in Healthy Adult Subjects | January 29, 2018 | March 11, 2019 |
| NCT03881826 | Completed | N/A | Investigation of the Gut Microbiota in Patients With Acute Myeloid Leukemia | December 4, 2015 | November 10, 2020 |
| NCT04299048 | Completed | Phase 1 | Study to Assess the Safety and Tolerability of Repeated Doses of an Investigational New Drug in Patients With Cancer and Cachexia. | November 17, 2020 | March 30, 2022 |
| NCT04585841 | Completed | Phase 1 | The Effect of Cannabidiol on Lean Body Mass in Patients Receiving Chemotherapy | December 1, 2020 | November 1, 2022 |
| NCT04631978 | Completed | Analysis of Retinochoroidal Vasculature in Underweight Women Using Optical Coherence Tomography Angiography | June 1, 2020 | August 30, 2020 | |
| NCT04698798 | Completed | N/A | Skeletal Muscle Wasting in SARS-CoV-2 | January 2, 2021 | April 3, 2021 |
| NCT04802486 | Completed | N/A | The Effects of a 12 Week Home-based Exercise Intervention on Physical Performance in Patients With Cancers of the Gastrointestinal Tract With Pre- Cachexia or Cachexia | June 29, 2016 | February 15, 2019 |
| NCT04803305 | Completed | Phase 1 | Study to Compare the Effects of Repeated Doses of an Investigational New Drug and a Placebo on Appetite in Advanced Cancer and Anorexia | May 11, 2021 | August 9, 2022 |
| NCT04815551 | Completed | Phase 1 | A Phase 1 Study of AV-380 in Healthy Subjects | February 22, 2021 | January 14, 2022 |
| NCT05023499 | Completed | Perioperative Glutamine Supplementation and Cachexia | January 1, 2016 | August 14, 2021 | |
| NCT05529849 | Completed | Phase 1 | A Study to Assess the Safety, Tolerability and Pharmacokinetics of TCMCB07 in Single and Multiple Ascending Doses in Health Subjects | July 12, 2022 | February 20, 2023 |
| NCT06028321 | Completed | Phase 1 | Study of Comparative Bioavailability and Pharmacokinetics of ACM-001.1) and Pindolol in Healthy Volunteers (HV) | November 26, 2021 | June 2, 2022 |
| NCT00637572 | Completed | Phase 2 | Evaluate Weight Gain Using 2 Different Formulations of Megestrol Acetate Oral Suspension for AIDS-related Weight Loss | December 2004 | June 2005 |
| NCT05028192 | Enrolling by invitation | Mitochondria Preservation by Exercise Training: a Targeted Therapy for Cancer and Chemotherapy-induced Cachexia | September 27, 2021 | September 1, 2024 | |
| NCT06077734 | Not yet recruiting | Muscle Stem Cell Quality in Atrophy | November 2023 | November 2025 | |
| NCT05865535 | Recruiting | Phase 1 | A Dose Escalation Study of AV-380 in Metastatic Cancer Patients With Cachexia | June 13, 2023 | September 30, 2025 |
| NCT04627376 | Recruiting | N/A | Multimodal Program for Cancer Related Cachexia Prevention | September 24, 2020 | June 2026 |
| NCT05623852 | Recruiting | N/A | The Impact of Oligo-Fucoidan in Cancer Cachexia and Sarcopenia | January 30, 2022 | April 30, 2025 |
| NCT04600154 | Recruiting | N/A | MS-20 on Gut Microbiota and Risk/Severity of Cachexia in Pancreatic Cancer Patients | August 10, 2021 | June 30, 2023 |
| NCT05642819 | Recruiting | REVOLUTION Surgery (REVOLUTION Surgery) | October 1, 2023 | December 2027 | |
| NCT05723718 | Recruiting | MalnutritiOn Assessment With biOelectrical impedaNce Analysis in gastRic Cancer patIentS Undergoing Multimodal trEatment | December 20, 2022 | December 31, 2028 | |
| NCT04906746 | Recruiting | Early Phase 1 | Ruxolitinib for Cancer Cachexia | February 23, 2022 | February 2025 |
| NCT05307367 | Recruiting | N/A | Cancer-associated Muscle Mass - Molecular Factors and Exercise Mechanisms | April 1, 2022 | January 1, 2028 |
| NCT05376592 | Recruiting | Assoc. of Genomic Polymorphisms With Cancer Cachexia in Subjects With Panc Adenocarcinoma | June 17, 2022 | August 2028 | |
| NCT06206785 | Recruiting | Resting Energy Expenditure in Palliative Cancer Patients | September 5, 2023 | December 31, 2027 | |
| NCT06112964 | Recruiting | Neurobehavioural and Cognitive Changes in Cancer Cachexia (CANCOG) | February 15, 2024 | November 2027 | |
| NCT06277986 | Recruiting | Early Diagnosis of Gastric Cancer Cachexia | June 1, 2021 | September 1, 2024 | |
| NCT05603585 | Recruiting | N/A | Optimal Protein Supplementation and Early Exercise In Mechanically Ventilated Patients | September 6, 2022 | September 30, 2023 |
| NCT05063955 | Recruiting | Mechanism of Sarcopenia in Heart Failure | December 2, 2020 | December 31, 2033 | |
| NCT05912465 | Recruiting | N/A | Predicting Lung Cancer-Associated Cachexia With PET Imaging | July 1, 2023 | March 1, 2025 |
| NCT05606523 | Recruiting | Microbiota and Pancreatic Cancer Cachexia | August 1, 2022 | April 30, 2025 | |
| NCT05899205 | Recruiting | Patient Recorded Indexing Measurements | June 1, 2021 | June 1, 2025 | |
| NCT01865903 | Terminated | Nutritional Problems and Changes in Body Composition in Patients With Non-small Cell Lung Cancer (LEKS) | June 15, 2013 | February 4, 2020 | |
| NCT00625742 | Terminated | N/A | Multimodal Treatment Strategy for Cancer Cachexia | February 2008 | June 2014 |
| NCT00637728 | Terminated | Phase 3 | Treatment of Cancer-anorexia Using Megestrol Acetate Concentrated Suspension in Lung or Pancreatic Cancer Patients | June 2006 | September 2006 |
| NCT00637806 | Terminated | Phase 3 | Treatment of Cancer-associated Anorexia Using Megestrol Acetate Concentrated Suspension | June 2006 | September 2006 |
| NCT00851448 | Terminated | N/A | Safety, Tolerance and Efficacy of an Oral Nutritional Supplement in Lung Cancer Patients | October 2009 | April 2011 |
| NCT00962234 | Terminated | Metabolism of Lipids in Advanced Cancer | October 2009 | October 2011 | |
| NCT00535015 | Terminated | Phase 2 | Safety and Efficacy Study of Betamarc to Treat Loss of Weight and Appetite in Non-Small Cell Lung Cancer | October 2007 | August 2008 |
| NCT01262690 | Terminated | Phase 1 | A Study In Healthy Subjects Of Single Doses of PF-05230901 Injected Under The Skin | November 2010 | September 2011 |
| NCT00558558 | Terminated | Phase 2 | Haelan and Nutrition in Cancer Patients | October 2007 | August 2009 |
| NCT02416570 | Terminated | Phase 2 | Is Clarithromycin a Potential Treatment for Cachexia in People With Lung Cancer? | April 2015 | October 2015 |
| NCT05128318 | Terminated | N/A | TuLip : Role of the Tumor Environment in Cancer-related Fat Loss | November 16, 2022 | April 22, 2024 |
| NCT02580422 | Terminated | Pilot Project for Cardiopulmonary and Functional Evaluation in Patients With Pancreatic Cancer Associated Cachexia | October 1, 2015 | October 26, 2017 | |
| NCT02650570 | Terminated | Mitochondrial Respiratory Function in Mammalian Skeletal Muscle | February 14, 2017 | March 29, 2017 | |
| NCT02686866 | Unknown status | Phase 4 | Body Composition Measurements in Chronic Heart Failure | January 2016 | June 2016 |
| NCT03570242 | Unknown status | N/A | WB-EMS and Individualized Nutritional Support in Gynecological Cancer Patients | July 1, 2017 | June 30, 2020 |
| NCT04594863 | Unknown status | The Investigation of the Mechanism of Cachexia Occurrence for Patients With Gastrointestinal Cancer | November 1, 2020 | June 1, 2021 | |
| NCT00172614 | Unknown status | The Roles of Cytokines in the Mechanism of Insulin Resistance and Energy Balance | December 2004 | ||
| NCT01829880 | Unknown status | Impact of Body Composition on Bisoprolol and Ramipril Pharmacokinetics in Patients With Chronic Heart Failure | October 2011 | August 2013 | |
| NCT04628975 | Unknown status | N/A | PeRfusion Emergency VEiNlite Transillumination | January 2021 | July 2022 |
| NCT03561610 | Unknown status | N/A | Novel Form of Nutritional Supplementation in Cancer Patients | May 1, 2018 | May 1, 2019 |
| NCT03111771 | Unknown status | Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract | November 2016 | September 2017 | |
| NCT02926261 | Unknown status | Methods for Nutritional Assessment in Cirrhosis | December 2016 | December 2021 | |
| NCT05161975 | Unknown status | N/A | Vitamin K2 Supplements for Muscle Recovery | December 15, 2021 | December 31, 2023 |
| NCT04907864 | Unknown status | Phase 2 | Effect of Multi-modal Intervention Care on Cachexia in Patients With Advanced Cancer Compared to Conventional Management (MIRACLE) | January 31, 2020 | June 30, 2022 |
| NCT00710632 | Unknown status | N/A | Screening to Predict Weight Loss in Patients With Cancer | September 2007 | |
| NCT02802540 | Unknown status | Phase 2/Phase 3 | Nabilone Effect on the Attenuation of Anorexia, Nutritional Status and Quality of Life in Lung Cancer Patients | December 2014 | July 2017 |
| NCT02798003 | Unknown status | Food Reward in Cachexia Induced by Acute or Chronic Disease | November 2016 | September 2018 | |
| NCT01395563 | Withdrawn | N/A | Strength Training on Pancreatic Cancer | January 2009 | December 2011 |
| NCT02017925 | Withdrawn | N/A | Pulmonary Rehabilitation in Improving Lung Function in Patients With Locally Advanced Non-Small Cell Lung Cancer Undergoing Chemoradiation | October 2013 | March 2017 |
| NCT00163072 | Withdrawn | Phase 4 | Pharmacokinetics and Safety of Transdermal Megestrol Acetate | October 2005 | December 2012 |
| NCT00093678 | Withdrawn | N/A | Celecoxib in Managing Pain, Weight Loss, and Weakness in Patients With Advanced Cancer |
- HPO Human Phenotype ID (Human Phenotype Ontology)
- HP:0004326
- ICD10 preferred id (Insert disease from ICD10)
- D0015170
- ICD10 class code (Insert disease from ICD10)
- R64
- MeSH unique ID (MeSH (Medical Subject Headings))
- D002100