Annotation Detail
Information
- Associated Genes
- TNF
- Associated Variants
-
TNF MUTATION
TNF MUTATION - Associated Disease
- pancreatic ductal adenocarcinoma
- Source Database
- DisGeNET
- Description
- These results not only suggest that GSK-3β overexpression and nuclear localization contribute to TNFα and TRAIL resistance via anti-apoptotic NF-κB genes such as Bcl-xL, but also provide a rationale for further exploration of GSK-3 inhibitors combined with TRAIL for the treatment of PDA.
- Pubmed
- 24675460
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 9
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00162865123248182
Drugs