Tobacco use disorder

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Information
Disease name
Tobacco use disorder
Disease ID
Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT04228965 Active, not recruiting Phase 4 Cannabis and Tobacco Co-use Study January 28, 2020 September 26, 2024
NCT04033237 Active, not recruiting Phase 1/Phase 2 Project 4, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Pregnant Women August 21, 2019 July 2024
NCT04092101 Active, not recruiting Phase 2 Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder September 18, 2019 January 2024
NCT04498988 Active, not recruiting Volitional Dysfunction in Self-control Failures and Addictive Behaviors December 1, 2014 June 30, 2024
NCT03519451 Active, not recruiting N/A Use of a Smartphone Mobile Application (App) to Enhance Smoking Cessation Treatment April 25, 2018 December 31, 2024
NCT00542373 Active, not recruiting N/A Widefield Fluorescence and Reflectance Imaging Systems and Oral Tissue Samples in Monitoring Participants at Risk for Developing Oral Cancer August 27, 2007 April 30, 2025
NCT04090879 Active, not recruiting Phase 2 Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders September 18, 2019 January 2024
NCT04092387 Active, not recruiting Phase 2 Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age September 18, 2019 January 2024
NCT03365362 Active, not recruiting Phase 4 A Trial of Directly Observed and Long-term Varenicline October 25, 2018 May 17, 2024
NCT02697227 Active, not recruiting N/A Behavioral Activation Therapy and Nicotine Replacement Therapy in Increasing Smoking Cessation August 5, 2016 December 31, 2024
NCT02271919 Active, not recruiting Phase 4 Varenicline and Combined NRT for Smoking Cessation May 14, 2015 June 30, 2025
NCT00060814 Completed Phase 2 Combination Pharmacotherapy for Smoking Cessation Among Methadone Patients June 2002 December 2002
NCT00061061 Completed Phase 4 Tobacco Cessation in Postmenopausal Women (Part I) - 1 March 1997 March 2003
NCT00061074 Completed Phase 1 Tobacco Cessation in Postmenopausal Women (Part II) - 2 March 1993 March 2000
NCT00063323 Completed Phase 3 Maintenance Treatment for Abstinent Smokers August 2000 July 2006
NCT00064922 Completed Phase 2/Phase 3 Incentive Programs for Female Substance Abusers Who Smoke - 3 January 2002 April 2006
NCT00067158 Completed Phase 3 Smoking Cessation Treatment With Transdermal Nicotine Replacement Therapy - 1 April 2003 July 2004
NCT00086385 Completed Phase 3 Maintaining Nonsmoking: Older Smokers - 1 September 2001 March 2009
NCT00086411 Completed Phase 2 Comparing Smoking Treatment Programs for Lighter Smokers - 1 September 2003 June 2009
NCT00087880 Completed Phase 2 Maintaining Abstinence in Chronic Cigarette Smokers - 1 December 2002 September 2009
NCT00104598 Completed N/A Framing Messages for Smoking Cessation With Bupropion - 6 September 2000 December 2006
NCT00107575 Completed Phase 2 Improving Smoking Cessation Outcomes in Heavy Drinkers - 1 August 2003 April 2008
NCT00108537 Completed Phase 3 Non-Nicotine Agents for Smoking Cessation October 2003 September 2005
NCT00109460 Completed Phase 2 Tobacco Cessation Field Study for Adults in Recovery - 1 March 2003 March 2005
NCT00110630 Completed Phase 3 Smoking Treatment of Prisoners June 2005 September 2007
NCT00110825 Completed N/A Behavioral Smoking Cessation Treatment - 1 February 2004 June 2009
NCT00111501 Completed Phase 3 LGBT Internet Based Smoking Treatment - 1 September 2002 January 2009
NCT00118534 Completed N/A Integrating Clinical Practice Guidelines for Smoking Cessation Into Mental Health Care for Veterans With Posttraumatic Stress Disorder July 2004 June 2009
NCT00124683 Completed Phase 2 Treating Nicotine Dependence in Schizophrenic Individuals: Effectiveness of Bupropion - 1 September 2001 May 2007
NCT00128375 Completed N/A Financial Incentives for Smoking Cessation March 2005 April 2008
NCT00129272 Completed Phase 2 Effectiveness of Bupropion for Treating Nicotine Dependence in Young People May 2004 January 2011
NCT00134927 Completed A Survey on Consumer Use of Over-the-Counter (OTC) Nicotine Patches September 2005 November 2006
NCT00135746 Completed N/A Examining the Effectiveness of the Nicotine Patch in Male and Female Smokers - 2 May 2004 June 2007
NCT00135772 Completed Nicotine and Cotinine Levels in Smokers With Schizophrenia and Schizoaffective Disorder - 2 October 2003 July 2004
NCT00136747 Completed Phase 1 The Effects of Memantine and Bupropion on Acute, Reinforcing, and Conditioned Effects of Cigarettes - 1 January 2004 May 2009
NCT00136760 Completed Phase 2 Contingent Incentives Plus Bupropion for Smoking in People With Schizophrenia September 2003 March 2009
NCT00136786 Completed Phase 1 Effect of Memantine Versus Bupropion on Smoking Relapse in Nicotine-Dependent Individuals - 3 December 2006 May 2009
NCT00136812 Completed N/A Treating Tobacco Dependence in Inpatient Psychiatry - 1 July 2006 April 2011
NCT00136838 Completed N/A Effect of Smoking Exposure on Smoking Relapse Following Brief Abstinence - 2 October 2001 June 2006
NCT00142831 Completed Phase 4 Bupropion as an Adjunct to the Nicotine Patch Plus CBT April 1999 August 2006
NCT00158145 Completed Assessing the Variability Over Time of Tobacco Carcinogen Biomarkers in Smokers - 2 September 2005 April 2007
NCT00158158 Completed Phase 2/Phase 3 Effectiveness of Reducing Smoking in Facilitating Smoking Cessation in Adolescents - 2 September 2005 September 2007
NCT00158171 Completed Phase 2 Effectiveness of Various Smoking Cessation Therapies in Reducing Smoking in Adolescents - 1 April 2002 May 2004
NCT00176449 Completed Phase 4 A Comparison of Bupropion SR and Placebo for Smoking Cessation April 2001 December 2005
NCT00178685 Completed Phase 4 Smokers' Health Project: Self-Determination and Maintaining Tobacco Abstinence August 2004 August 2008
NCT00184184 Completed Registration of Tobacco, Coffee and Substance Use Among Acutely Admitted Psychiatric Patients October 2004 June 2005
NCT00208858 Completed Phase 2 A Pilot Study of the Neural Correlates of Treatment Effect on Nicotine Craving December 2004 December 2006
NCT00217984 Completed N/A Intensive Intervention for Smokers - 6 July 2006 June 2010
NCT00218140 Completed Phase 2 Effectiveness of the Nicotine Patch in Suppressing Nicotine Withdrawal Symptoms in Women Versus Men - 1 April 2005
NCT00218153 Completed Phase 3 Naltrexone Augmentation of Nicotine Patch Therapy - 1 November 2000 April 2004
NCT00218179 Completed Assessing the Link Between Smoke Carcinogen Biomarkers and Lung Cancer Risk - 1 September 2005 December 2007
NCT00218218 Completed Phase 2 Effects of Transdermal Nicotine on Smoking, Craving and Withdrawal in People With Schizophrenia June 2002 February 2005
NCT00218231 Completed Phase 2 Effect of Bupropion on Smoking Behavior in Smokers With Schizophrenia January 2004 August 2006
NCT00218244 Completed Phase 1/Phase 2 Using Smokeless Tobacco Products With Lower Nicotine Levels to Reduce Negative Effects of Smokeless Tobacco Use August 2001 November 2004
NCT00218270 Completed Phase 2 Effectiveness of Using Tobacco Free Snuff in Reducing Negative Effects of Smokeless Tobacco Use December 2002 May 2005
NCT00218283 Completed Phase 2 Nicotine Lozenge to Reduce Smokeless Tobacco Use January 2005 June 2007
NCT00218296 Completed Phase 2 Comparison Across Treatment Conditions to Reduce Smokeless Tobacco Use November 2006 January 2009
NCT00218439 Completed N/A Effect of Paroxetine on Smokers' Cardiovascular Response to Stress - 1 October 2005 August 2010
NCT00222703 Completed N/A Enhancing Tobacco Abstinence Following Hospitalization May 2002 March 2005
NCT00227786 Completed N/A Primary Care Physicians' Use of Stop-Smoking Plans to Help Patients Who Are Smokers January 2003 May 2006
NCT00258479 Completed Phase 1 Safety of Combining Modafinil and Nicotine Replacement Therapy in Treating Nicotine Dependent Adolescents June 2003 December 2011
NCT00264342 Completed Effectiveness of Using Reduced Nicotine Cigarettes in Men and Women Smokers to Combat Nicotine Addiction July 2005 July 2010
NCT00271206 Completed Phase 1 Effect of Progesterone on Smoking Behavior in Male and Female Smokers September 2004 September 2008
NCT00308763 Completed N/A Nicotine Patch and Bupropion to Reduce Smoking Rates in Younger, Low-Income, and Minority Individuals January 2004 December 2008
NCT00310115 Completed Motivational Counseling in Preventing Smoking Relapse After Pregnancy in Pregnant Women Who Quit Smoking During Pregnancy April 2002 August 2016
NCT00363428 Completed N/A Lung Rehabilitation in Treating Patients With Chronic Obstructive Pulmonary Disease Who Are Undergoing Surgery for Lung Cancer August 2006 November 1, 2012
NCT00365209 Completed Phase 2 Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci) October 2006 January 2011
NCT00365508 Completed Phase 4 Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking February 2006 August 2009
NCT00368927 Completed Phase 2 Sulindac in Preventing Lung Cancer in Current or Former Smokers With Bronchial Dysplasia August 2006 December 2010
NCT00376987 Completed Phase 2 Zinc Supplements in Lowering Cadmium Levels in Smokers December 2003 June 2015
NCT00383461 Completed N/A Computer-Based Stop Smoking Program in Assisting Doctors in Helping Adults Stop Smoking April 2006 September 2007
NCT00469885 Completed Phase 2 Reduction of Smoking in Cardiac Disease Patients January 2001 December 2005
NCT00507728 Completed Phase 2/Phase 3 Pharmacogenetics, Emotional Reactivity and Smoking December 8, 2005 December 18, 2019
NCT00519766 Completed Examining a New Biomarker of Nicotine Use Among Pregnant Women Who Participated in the New England SCRIPT September 1997 November 2002
NCT00534001 Completed Phase 2 Bupropion in Helping Adults Stop Smoking January 2006 July 2015
NCT00534404 Completed N/A A Randomized Trial of Internet Access to Nicotine Patches March 2011 March 2014
NCT00548470 Completed Phase 4 Varenicline Effects In Schizophrenic Smokers June 2007 December 2010
NCT00573885 Completed Phase 2 Green Tea Extract in Preventing Cancer in Former and Current Heavy Smokers With Abnormal Sputum January 2008 December 2008
NCT00587353 Completed Phase 2 Tobacco Use Intervention Among Radiation Oncology Patients January 2008 December 2009
NCT00587769 Completed Phase 3 Chantix & Bupropion for Smoking Cessation July 2007 July 2008
NCT00595868 Completed Phase 2 Efficacy of Varenicline in Ambivalent Smokers March 2008 January 2010
NCT04609514 Completed N/A Learn to Quit-HIV Pilot Study January 25, 2021 June 2, 2022
NCT00000288 Completed Phase 2 Role of Metabolites in Nicotine Dependence (2) - 5 December 1995 December 2002
NCT00000289 Completed Phase 2 Role of Metabolites in Nicotine Dependence (3) - 6 May 1998 December 2001
NCT00000295 Completed Phase 2 Progesterone Treatment in Female Smokers - 12 April 1999 December 2001
NCT00000296 Completed Phase 2 Role of Metabolites in Nicotine Dependence (4) - 13 November 1997 December 2001
NCT00000297 Completed Phase 2 Effects of Labetalol on Nicotine Administration in Humans - 14 October 1998 December 2001
NCT00002520 Completed N/A Physician-Initiated Stop-Smoking Program for Patients Receiving Treatment for Early-Stage Cancer December 7, 1990
NCT00006151 Completed N/A Combining a Smoke Ending Aid With Behavioral Treatment - 1 May 1999 February 2002
NCT00006170 Completed Phase 4 Bupropion and Weight Control for Smoking Cessation - 1 September 2000 September 2010
NCT00051883 Completed Chemical Dependency and Smoking Cessation: Patient's Views - 1 December 1999 February 2005
NCT00059514 Completed Tobacco Use Among Arab American Youth May 2000 May 2006
NCT02188563 Completed N/A A Comprehensive Smoking Cessation Intervention Duration Radiation for Upper Aerodigestive Cancers May 2014 May 2016
NCT02232737 Completed Phase 1/Phase 2 Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders October 7, 2016 January 14, 2019
NCT02245308 Completed Phase 4 Abstinence Reinforcement Therapy (ART) for Homeless Veteran Smokers October 1, 2014 September 28, 2018
NCT02250534 Completed Phase 1/Phase 2 Project 1, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Childbearing Age Women October 2016 October 2019
NCT02250664 Completed Phase 1/Phase 2 Project 2, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Opioid Abusers October 2016 October 2019
NCT02265367 Completed N/A Novel Medication as a Potential Smoking Cessation Aid January 2015 May 2017
NCT02277665 Completed N/A Clinical Trial Tobacco Marijuana December 18, 2014 January 18, 2017
NCT02327104 Completed N/A Effectiveness of Mindfulness Based Relapse Prevention for Tobacco Dependents October 2012 August 2016
NCT02342327 Completed N/A Smoking Cessation in Menthol Flavored Cigarette Smokers October 28, 2014 July 11, 2018
NCT02347605 Completed N/A Medicinal Nicotine for Preventing Cue Induced Craving September 2013 January 2015
NCT02348203 Completed Phase 2 Aspirin and Zileuton and Biomarker Expression in Nasal Tissue of Current Smokers January 13, 2016 March 9, 2021
NCT02392182 Completed Lung HIV Microbiome Project (Michigan Site) October 2009 April 2015
NCT02393547 Completed Phase 1/Phase 2 Lorcaserin for Preventing Weight Gain Among Smokers September 2013 December 2015
NCT02401022 Completed Phase 2 The Study of AZD8529 for Smoking Cessation in Female Smokers July 2015 January 2017
NCT02406066 Completed Phase 1 Single and Multiple Rising Dose Study of Safety and PK of Metyrapone/Oxazepam Combination (EMB-001) March 2015 June 2016
NCT02421224 Completed N/A Social and Monetary Incentives for Smoking Cessation at Large Employers April 2015 August 2017
NCT02439255 Completed N/A Effect of Black Raspberry Phytochemicals on Oral Microbiome in Current Smokers and Non-smokers December 4, 2015 April 30, 2022
NCT02506829 Completed N/A Financial Incentives for Smoking Treatment July 2015 May 20, 2019
NCT02560324 Completed Phase 2 Effect of Ramelteon on Smoking Abstinence September 2015 August 2018
NCT02571244 Completed N/A Text Messaging for Supporting Quit Attempts June 2015 March 8, 2016
NCT02596685 Completed N/A Effects of Electronic Cigarette Use on the Lungs December 8, 2015 February 2, 2021
NCT02601521 Completed N/A Comparative Effectiveness of Two Tobacco Cessation Interventions for Employees of Partners HealthCare, Inc. November 2015 March 2020
NCT02628964 Completed N/A Electronic Cigarettes (E-cigarettes) as a Harm Reduction Strategy May 2015 March 26, 2018
NCT02688374 Completed Phase 1 A Bioequivalence Study of Three, 2 mg Nicotine Chewing Gums (Two Tests and One Reference) in Healthy Adult Smokers March 11, 2016 June 12, 2016
NCT02781038 Completed N/A Smoking Cessation and a Teachable Moment in Patients With Acute Fractures February 2014 December 2015
NCT02781090 Completed N/A RCT of an Internet Cessation Program Plus Online Social Network for HIV+ Smokers July 6, 2016 September 14, 2020
NCT02888249 Completed N/A Behavioral Economic Purchasing Decisions for Cigarettes of Varied Compositions August 25, 2017 November 10, 2021
NCT02896400 Completed Phase 3 Optimizing Tobacco Dependence Treatment in the Emergency Department February 13, 2017 August 14, 2019
NCT02906995 Completed Phase 1 Pharmacokinetics of Nicotine Sublingual Tablets Versus Nicorette Lozenge in Healthy Smokers May 25, 2017 November 27, 2017
NCT02952703 Completed N/A Disseminating and Implementing a Smoking Cessation Program for Pregnant and Postpartum Women November 2016 May 2018
NCT02968095 Completed N/A Text Message Support to Prevent Smoking Relapse August 7, 2018 August 23, 2019
NCT02991534 Completed N/A Cardiovascular Risk Screening and Risk Reduction in Women Vets November 15, 2016 September 30, 2020
NCT03000387 Completed Phase 4 Personalized Dosing of Nicotine Replacement (NRT to Effect) January 23, 2018 December 11, 2023
NCT03017092 Completed N/A Tobacco Pilot Study for Low Income Smokers January 18, 2017 January 27, 2017
NCT03060083 Completed Phase 2/Phase 3 Switching to Very Low Nicotine Content Cigarettes vs Reducing Cigarettes Per Day February 8, 2017 January 10, 2018
NCT03163056 Completed N/A Smoking Cessation Treatment for Depressed Smokers January 26, 2015 July 31, 2019
NCT03164668 Completed N/A Menthol Flavored E-cigarette Use During a Simulated Ban of Menthol Cigarettes May 3, 2017 November 26, 2019
NCT03237949 Completed N/A Text Messaging and Telephone Counseling for Supporting Post-discharge Quit Attempts May 30, 2017 January 31, 2020
NCT03259360 Completed N/A A Facebook Intervention for Young Sexual and Gender Minority Smokers April 23, 2018 February 28, 2020
NCT03337113 Completed Phase 2 Working Memory Training Combined With Transcranial Magnetic Stimulation in Smokers March 5, 2018 January 31, 2021
NCT03386253 Completed N/A Effect of a Non-Invasive Brain Stimulation Technique on Smoking Cessation Behaviors January 1, 2018 November 21, 2018
NCT03402243 Completed N/A Effect of Banning Menthol Flavorant on Cigarette and E-Cigarette Use February 26, 2018 March 25, 2020
NCT03496077 Completed N/A Addictive Potential of LCCs in Dual Users August 28, 2018 December 31, 2020
NCT03541044 Completed Phase 1 A Bioequivalence Study of Two Nicotine Lozenges in Fasting Conditions in Healthy Smokers June 18, 2018 March 24, 2019
NCT03543137 Completed Phase 1 To Assess the Bioequivalence of the 4mg Prototype Mini Nicotine Lozenge to the Reference Product (Nicorette) in Healthy Smokers June 18, 2018 November 12, 2018
NCT03551704 Completed N/A Smoking Cessation Treatment for Substance Use Dependents January 15, 2018 December 30, 2022
NCT03553992 Completed N/A An Extended Facebook Intervention for Young Sexual and Gender Minority Smokers October 29, 2018 July 7, 2019
NCT03626064 Completed N/A The PROMPT Pilot Study June 2014 March 2017
NCT03691805 Completed N/A Transcranial Direct Current Stimulation - Tobacco Use Disorder October 15, 2018 February 18, 2020
NCT03694327 Completed N/A Innovative Digital Therapeutic for Smoking Cessation October 24, 2018 March 14, 2019
NCT03764969 Completed N/A Modification of Goal-directed and Habitual Behavior in Addiction January 7, 2020 June 23, 2023
NCT03813121 Completed Phase 1/Phase 2 The Effects of Sedatives on Tobacco Use Disorder June 1, 2019 August 31, 2021
NCT03841292 Completed N/A Using Non-invasive Brain Stimulation (tDCS) With Varenicline for Treating Tobacco Dependence October 1, 2018 January 31, 2022
NCT03873337 Completed N/A Persistence Targeted Smoking Cessation in Serious Mental Illness (SMI) April 22, 2019 January 31, 2022
NCT03960138 Completed N/A Examining the Effects of Neural Stimulation on Inhibitory Control and Cigarette Smoking September 26, 2019 April 25, 2021
NCT04055467 Completed Phase 1 Brain Imaging in Tobacco Smokers During a Quit Attempt December 16, 2019 November 30, 2022
NCT04083144 Completed N/A Deep rTMS and Varenicline for Smoking Cessation August 22, 2019 December 30, 2022
NCT04194918 Completed Phase 1 Flexiquit+: Web Program to Promote Smoking Cessation in Sexual and Gender Minority Young Adult Smokers May 18, 2020 September 1, 2020
NCT04250727 Completed N/A Switching to Potential Reduced Exposure Products in Adult Smokers May 1, 2021 August 17, 2022
NCT04251936 Completed N/A Modification of Alternative Reward Cue Reactivity and Cognitive Control Through Physical Activity in Human Tobacco Use Disorder February 1, 2020 June 30, 2023
NCT04332029 Completed N/A Smoking Cessation Treatment for Smokers With Obesity October 7, 2020 February 28, 2023
NCT04560868 Completed Phase 1 Development of a mHealth Intervention for Ambivalent Smokers December 16, 2020 September 27, 2021
NCT00000284 Completed Phase 2 Role of Metabolites in Nicotine Dependence (1) - 1 February 1995 December 2001
NCT04646668 Completed N/A Comparative Abuse Liability Among African American and White Smokers September 21, 2020 August 26, 2021
NCT04768114 Completed N/A Implementation of Genomics in Substance Use Disorder Treatment March 19, 2021 December 7, 2022
NCT04772014 Completed Evaluation of the Addictive Potential of E-Cigarettes December 1, 2020 August 29, 2023
NCT04996940 Completed N/A Comparative Acceptability of Tobacco and Menthol Flavored E-cigarettes June 20, 2021 August 15, 2021
NCT04999644 Completed Early Phase 1 Reduced Nicotine Cigarette Purchasing Decisions February 23, 2022 March 29, 2023
NCT05024747 Completed Phase 1 A Bioequivalence Study of 21 Milligram (mg) Nicotine Transdermal Patches (NicoDerm CQ, GlaxoSmithKline [GSK] Dungarvan) Compared to the Current Marketed 21 mg Nicotine Transdermal Patches (NicoDerm CQ, Alza) in Healthy Adult Smokers September 1, 2021 October 25, 2021
NCT05110872 Completed N/A Cigarette and E-cigarette Flavors Manipulations in the Experimental Tobacco Marketplace July 26, 2021 August 13, 2021
NCT05447156 Completed N/A QuitGuide for American Indians: Aims 2 & 3 December 14, 2022 November 29, 2023
NCT00618280 Completed Phase 1/Phase 2 Social Cognition,Attentional Network and Nicotine Drug Dependency - A Pharmacological Clinical Trail January 2008 August 2010
NCT00618943 Completed Phase 3 Treating Tobacco Dependence in Adolescents With Co-occurring Psychiatric Disorders April 2008 April 2010
NCT00625131 Completed Early Phase 1 Nicotine Patch Pretreatment for Smoking Cessation in PTSD May 2008 March 2013
NCT00627185 Completed Early Phase 1 Dental Tobacco Control.Net:Improving Practice September 2003 August 2008
NCT00664261 Completed N/A Clinical Effort Against Secondhand Smoke (CEASE) Program or Standard Care in Helping Parents Stop Smoking September 2007 July 2013
NCT00666978 Completed Phase 4 Health Education Counseling With or Without Bupropion in Helping African Americans Stop Smoking December 2007 June 2010
NCT00670904 Completed N/A Randomized Trial Assessing the Effectiveness of a Pharmacist-Delivered Program for Smoking Cessation October 2005 November 2007
NCT00670995 Completed Phase 2 Tobacco Zero: Interactive Tobacco Education for Teens November 2009 November 2010
NCT00690924 Completed N/A Calcitriol in Preventing Lung Cancer in Smokers and Former Smokers at High Risk of Lung Cancer July 17, 2008 March 7, 2018
NCT00691132 Completed Phase 2 Phenethyl Isothiocyanate in Preventing Lung Cancer in Smokers February 2009 January 2013
NCT00710034 Completed Phase 2 Efficacy of Oral Tobacco Products Compared to a Medicinal Nicotine April 2010 May 2014
NCT00711100 Completed N/A Evaluation of Oral Tobacco as a Harm Reduction Method for Smokers August 2008 December 2010
NCT00740896 Completed N/A Acute Effects of Smoking on Airway Dendritic Cells June 2008 December 2008
NCT00790569 Completed N/A Varenicline or Nicotine Patch and Nicotine Gum in Helping Smokers in a Methadone Treatment Program Stop Smoking September 2008 October 2012
NCT00820495 Completed Phase 2 Effectiveness of a Web-Assisted Quitline for Smokeless Tobacco Users May 2009 May 2012
NCT00830739 Completed A Multi-Modal Investigation of the Smoking Cessation Medication Varenicline: Dopaminergic Modulation of Reward Processing and Cognitive Control November 25, 2008 February 26, 2013
NCT00871637 Completed Airway Macrophages and Sputum Milieu in Adult Subjects With Airflow Obstruction August 1, 2008 June 1, 2009
NCT00888979 Completed N/A Pilot Study of Nicotine Replacement for Smoking Cessation During Pregnancy April 2009 April 2014
NCT00937235 Completed Phase 2 Treatment of Smoking Among Individuals With PTSD January 2009 December 2015
NCT00957424 Completed N/A Acceptability of Less Harmful Alternatives to Cigarettes June 2009 November 2011
NCT00967005 Completed Phase 2 N-Acetyl Cysteine Plus Behavioral Therapy for Nicotine Dependent Pathological Gamblers September 2009 August 2014
NCT01001520 Completed Phase 2 Neural Substrates in Nicotine Withdrawal January 2010 October 2012
NCT01010620 Completed Screening Protocol for Research Participants December 2009 June 1, 2019
NCT01021215 Completed Phase 1/Phase 2 Zileuton With or Without Celecoxib As Chemopreventive Agents in Smokers May 2010 March 2013
NCT01023659 Completed Phase 4 Distribution of Bupropion and Varenicline to Increase Smoking Cessation Attempts April 2010 December 2011
NCT01038492 Completed N/A p16 Methylation for Smoking Cessation April 2009 June 2010
NCT01050569 Completed Phase 2 Innovative Interventions for Smoking Cessation October 2008 June 2012
NCT01067599 Completed N/A Novel Determinants and Measures of Smokeless Tobacco Use: Study 2 March 2012 October 2016
NCT01098305 Completed Phase 2 Efficacy of Varenicline for Smokeless Tobacco Use in India April 2011 October 2013
NCT01141855 Completed Phase 2/Phase 3 Smoking Termination Opportunity for inPatients May 2008 December 2011
NCT01166464 Completed N/A Examining a Text Message Intervention for Smoking Cessation July 2009 October 2012
NCT01213524 Completed Phase 2 Nicotine and Sensorimotor Replacement for Smoking in Smokers With Schizophrenia September 2005 March 2011
NCT01214005 Completed Phase 2 Smoking Abstinence and Lapse Effects in Smokers With Schizophrenia and Controls June 2009 February 2012
NCT01252966 Completed N/A Cognitive Training for Nicotine Dependence March 2011 September 2015
NCT01262170 Completed Phase 1 A Pilot Study to Evaluate Safety and Efficacy of CigRx™ in Smokers April 2010 April 2010
NCT01302262 Completed Smoking-induced Dopamine Release: a [11C]-(+)-PHNO PET Study in Humans February 2011 March 2013
NCT01303081 Completed N/A Pilot Randomized Control Trial of Financial Incentives for Smoking Cessation June 2011 June 2012
NCT01308736 Completed N/A Varenicline-Aided Cigarette Reduction in Smokers Not Ready to Quit January 2011 February 2014
NCT01323725 Completed N/A Team-based Financial Incentives for Smoking Cessation January 2011 December 2011
NCT01328431 Completed N/A Treating Low-Income Smokers in the Hospital Emergency Department October 2010 January 2014
NCT01329614 Completed Early Phase 1 Effects of Nicotine Replacement and Repeated Cue Exposure on Cigarette Craving October 2009 July 2013
NCT01330030 Completed Phase 2 Selegiline Patch for Treatment of Nicotine Dependence July 2005 July 2011
NCT01333202 Completed N/A Fresh Lime Alone for Smoking Cessation March 2009 September 2009
NCT01336816 Completed Phase 1 A Pilot Study to Evaluate the Efficacy of Ariva® Silver Wintergreen, a Smoking Aversive Lozenge July 2009 July 2009
NCT01337817 Completed Phase 1 A Pilot Study to Evaluate the Efficacy and Safety of Ariva® Silver Wintergreen in Healthy Smokers September 2009 September 2009
NCT01337830 Completed Phase 1 Pilot Study to Evaluate the Safety and Efficacy of Ariva® Silver Wintergreen in Reducing Cigarette Craving in Smokers October 2010 October 2010
NCT01378858 Completed N/A Varenicline Smoking Cessation Treatment for Methadone Maintenance Patients July 2011 July 2015
NCT01390246 Completed Phase 4 Bupropion for Smoking Cessation During Pregnancy July 2011 December 2016
NCT01412866 Completed N/A Electronic Decision Support Systems for Smokers With Severe Mental Illness May 2011 May 2012
NCT01428310 Completed Phase 1 Study to Evaluate the Safety and Efficacy of Dietary Supplement Anatabloc in Reducing Daily Smokers' Urge to Smoke September 2011 December 2011
NCT01434342 Completed Early Phase 1 Feasibility of Delivering a Quitline Based Smoking Cessation Intervention in Cancer Patients October 1, 2011 January 1, 2015
NCT01442753 Completed N/A Family-Skills Training to Prevent Tobacco and Other Substance Use in Latino Youth September 2011 January 2015
NCT01457469 Completed Phase 1 Enhanced Quitline Intervention in Smoking Cessation for Patients With Non-Metastatic Lung Cancer January 2011 May 2012
NCT01497158 Completed N/A Promoting Home Smoking Restrictions: Biomarker Feedback to Smoking and Non-Smoking Adults June 2007 February 2012
NCT01522963 Completed N/A Medicinal Nicotine for Preventing Stress Induced Craving and Withdrawal Symptoms December 2011 January 2014
NCT01526265 Completed N/A Way to Quit - Comparative Efficacy, Acceptance and Effectiveness of Health Incentive Structures February 2012 November 2015
NCT01535040 Completed Phase 2 Memantine Hydrochloride in Helping Cancer Survivors Stop Smoking August 1, 2012 February 1, 2014
NCT01539525 Completed N/A Screening to Augment Referral to Treatment- Project START September 5, 2011 January 28, 2015
NCT01570595 Completed Phase 1/Phase 2 Positively Smoke Free on the Web (PSFW) for Smokers Living With HIV September 2011 September 2013
NCT01625637 Completed Phase 2 Tobacco Approach Avoidance Training for Adolescent Smokers-2 May 2012 August 2013
NCT01625767 Completed Phase 2 Tobacco Approach Avoidance Training for Adolescent Smokers-1 September 2011 March 2012
NCT01654107 Completed Phase 1 Persistence-Targeted Smoking Cessation July 2012 September 2014
NCT01669538 Completed Phase 2 Effect of Galantamine on Short-term Abstinence August 2012 November 2017
NCT01673711 Completed Deuterated Phenanthrene Tetraol in Smokers Who Are at High Risk For Lung Cancer July 2012 September 30, 2019
NCT01691105 Completed N/A Implementation of HIT-Enhanced Tobacco Treatment for Hospitalized Smokers August 2013 September 2016
NCT01714323 Completed N/A Comparative Effectiveness of Post-Discharge Strategies for Hospitalized Smokers December 2012 October 2016
NCT01771627 Completed N/A Varenicline or Nicotine Patch in Promoting Smoking Cessation Among Current Smokers October 22, 2012 August 28, 2015
NCT01796951 Completed Early Phase 1 Low Dose Aspirin Inhibition of COX-2 Derived PGE2 in Male Smokers February 2013 February 2016
NCT01798394 Completed N/A Progesterone & Postpartum Relapse to Smoking June 2014 June 2016
NCT01829308 Completed N/A SBIRT Implementation for Adolescents in Urban Federally Qualified Health Centers April 2013 December 31, 2017
NCT01905618 Completed N/A Tobacco Treatment Medical Education in 10 Medical Schools July 2009 May 2014
NCT01930422 Completed N/A Effect of Transcranial Direct Current Stimulation (tDCS) on Tobacco Consumption July 2013 February 2014
NCT01972464 Completed Phase 2 Progesterone for Smoking Relapse Prevention Following Delivery November 2013 September 2016
NCT02123849 Completed Phase 2 Intermittent or Continuous Acetylsalicylic Acid and Gene Expression in the Nasal Tissue of Current Smokers June 2014 February 2018
NCT02146911 Completed N/A The MATCH (Medication Aids for Tobacco Cessation and Health) Study May 1, 2014 December 31, 2016
NCT02148445 Completed Phase 3 Smoking Cessation Versus Long-term Nicotine Replacement Among High-risk Smokers May 2014 December 2016
NCT02169271 Completed Phase 2 Acetylsalicylic Acid Compared to Placebo in Treating High-Risk Patients With Subsolid Lung Nodules November 21, 2014 February 14, 2020
NCT06042361 Enrolling by invitation N/A Enhancing Equity in Smoke-free Housing September 1, 2023 December 31, 2025
NCT06432985 Not yet recruiting Phase 2/Phase 3 Smoking Cessation CM for Veterans With or at Risk for Cancer June 30, 2024 March 30, 2030
NCT05389670 Not yet recruiting N/A Theta-burst Repetitive Transcranial Magnetic Stimulation (TBS) of the Right Inferior Frontal Gyrus for Treatment of Nicotine Dependence July 1, 2024 April 1, 2025
NCT05947162 Not yet recruiting N/A Effect of Orexin System on Nicotine Addiction and Its Neural Mechanism November 1, 2023 July 31, 2027
NCT05726045 Not yet recruiting N/A Increasing Smoking Cessation Success Through Sleep-amplified Memory Consolidation April 1, 2024 June 30, 2026
NCT06218056 Not yet recruiting Phase 2 Cannabidiol for Reducing Cigarette Use July 15, 2024 December 31, 2026
NCT05587361 Not yet recruiting Phase 4 Beta-Adrenergic Modulation of Drug Cue Reactivity June 1, 2024 March 30, 2025
NCT06350175 Not yet recruiting Phase 4 Emergency Department Management of Tobacco Use Disorder June 2024 June 2025
NCT06006143 Not yet recruiting N/A Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 2 January 1, 2025 December 31, 2025
NCT05499364 Not yet recruiting N/A TinCat LGBTQ+ Smoking Cessation Via Asynchronous Telehealth January 1, 2023 June 30, 2023
NCT05044546 Recruiting N/A A Behavioral Activation Prenatal and Postpartum Intervention for Depressed Pregnant Smokers October 19, 2021 April 30, 2024
NCT06239350 Recruiting N/A Young Adult Tobacco/Nicotine and Cannabis Co-use May 13, 2024 January 1, 2029
NCT05030272 Recruiting N/A Comparing Two Behavioral Approaches to Quitting Smoking in Mental Health Settings September 21, 2021 April 1, 2025
NCT05045326 Recruiting N/A Effectiveness of a Smoking Cessation Intervention in a Mental Health Day Hospital May 30, 2021 July 30, 2024
NCT05049460 Recruiting N/A Adjunctive Transcranial Stimulation to Reduce Impulsivity in Opiate Use Disorder September 15, 2021 July 31, 2024
NCT06405074 Recruiting N/A Low Intensity Focused Ultrasound for Tobacco Use Disorder: High Resolution Targeting of the Human Insula April 1, 2022 March 31, 2026
NCT05294263 Recruiting Phase 2 Varenicline for the Treatment of Cannabis and Tobacco Use Disorders in Veterans April 17, 2023 December 31, 2025
NCT05445804 Recruiting Phase 1 Oral Cannabidiol for Tobacco Cessation November 1, 2022 April 1, 2025
NCT03713424 Recruiting Phase 2 An fMRI Study of the Effects of Clavulanic Acid on Drug Addiction March 26, 2019 December 31, 2024
NCT05452772 Recruiting Phase 2 5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder November 1, 2023 December 2025
NCT03827265 Recruiting N/A Transcranial Magnetic Stimulation and Tobacco Use Disorder February 1, 2019 February 2024
NCT05530577 Recruiting Phase 2 Effects of Semaglutide on Nicotine Intake October 7, 2022 May 2024
NCT03948893 Recruiting N/A Smoking Cessation Behavioral Treatment Study December 19, 2019 March 31, 2024
NCT03950427 Recruiting Phase 4 PARQuit Smoking Cessation Intervention for Adults With Serious Mental Illness July 8, 2019 July 1, 2025
NCT04132232 Recruiting N/A Smoking Reduction In Gravid Substance Use Disorders February 15, 2021 December 1, 2023
NCT05723588 Recruiting Phase 2 Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD October 31, 2023 November 1, 2027
NCT05729243 Recruiting Phase 4 Cytisine for Smoking Cessation February 8, 2023 June 2024
NCT05766553 Recruiting N/A Effects of Mindfulness Meditation in Virtual Reality on Craving and Smoking Cessation June 15, 2023 December 15, 2026
NCT04417595 Recruiting Phase 2 Investigating N-3 Fatty Acids to Prevent Neonatal Tobacco-related outcomeS November 10, 2020 September 30, 2024
NCT04487470 Recruiting N/A Impact of Cigar Flavor in Dual Users June 24, 2020 May 31, 2024
NCT05875194 Recruiting N/A Influence of tDCS on the Brain Activation Measured During the Decision Not to Smoke in High-risk Situations October 15, 2022 December 15, 2023
NCT05885659 Recruiting N/A Smoking Cessation Program for Adults With Type 2 Diabetes Mellitus (DiMe-SALUD2 Project) September 1, 2023 December 31, 2025
NCT04627922 Recruiting Phase 4 N-Acetylcysteine for Smoking Cessation in Tobacco and Cannabis Co-Use August 25, 2021 August 25, 2024
NCT00119210 Terminated Phase 4 Pilot Study of Bupropion for Smoking Cessation in Postpartum Non-breastfeeding Women March 2005 March 2006
NCT02439944 Terminated Phase 2/Phase 3 Efficacy and Neural Correlates of Personalized Treatment With Transdermal Nicotine Replacement July 2015 December 2017
NCT00115687 Terminated Phase 2 Nicotine Replacement Treatment for Pregnant Smokers - 1 June 2002 April 2007
NCT04396834 Terminated Phase 2 Mechanisms of Lorcaserin for Smoking Cessation December 4, 2019 February 26, 2020
NCT00257894 Terminated Phase 2 Baclofen Effects on Smoking Urge and Withdrawal December 2005 December 2008
NCT05594810 Terminated N/A Tobacco Treatment Using EMDR (ToTEM) February 21, 2023 June 27, 2023
NCT03213418 Terminated N/A Electroretinogram: a New Human Biomarker for Smoking Cessation Treatment February 1, 2018 December 1, 2022
NCT04933916 Terminated Phase 1/Phase 2 Study of EMB-001 as a Potential Smoking Cessation Treatment June 10, 2021 May 1, 2023
NCT00046813 Terminated Phase 4 Nicotine Patch for Nicotine Dependence in Individuals With Schizophrenia or Schizoaffective Disorder - 1 August 2001 April 2005
NCT00611650 Terminated Phase 2 Green Tea Extract in Treating Current or Former Smokers With Bronchial Dysplasia October 2006 July 2011
NCT01800500 Terminated N/A Interest in Smokeless Tobacco Product as a Substitution for Cigarettes in Current Smokers September 2011
NCT00799669 Unknown status Cancer Risk Reduction Through Combined Treatment for Tobacco and Alcohol Use December 5, 2007 February 2020
NCT00751660 Unknown status N/A Screening Methods in Finding Lung Cancer Early in Current or Former Smokers September 2008
NCT02810574 Unknown status N/A Combining Noninvasive Brain Stimulation and Cognitive Training on Tobacco Craving March 2016 September 2017
NCT03922360 Unknown status N/A Smartphone-based Financial Incentives September 1, 2017 June 2021
NCT04868253 Unknown status Phase 2/Phase 3 Efficacy and Safety of Combination EMB-001 as a Potential Smoking Cessation Treatment May 19, 2021 December 31, 2021
NCT00396669 Unknown status N/A A Brain Imaging Study Into Nicotine Induced Dopamine Release in Cigarette Smokers. July 2007 July 2012
NCT01306552 Unknown status N/A Evaluation of a Combined Parent-student Programme for Smoking Prevention in Berlin Schools October 2010 August 2013
NCT00098215 Unknown status Phase 2 Pediatric Residency Training On Tobacco March 2001 February 2006
NCT04419922 Unknown status A Digital Smoking Cessation Intervention for Adults With Substance Use Disorder April 2, 2020 January 15, 2021
NCT01566097 Unknown status N/A Intervention Trial of Culturally-Appropriate Decision Aids for Smoking Cessation April 2012 July 2015
NCT00269009 Unknown status Phase 1 CHERL, Connecting Primary Care Patients With Community Resources to Facilitate Behavior Change January 2006 February 2007
NCT01065493 Unknown status Phase 2 QuitAdvisorMD: A Point-of-care Tool for Brief Smoking Cessation Interventions January 2011 April 2015
NCT01344005 Unknown status N/A Standard Medical Care or Urgent Chest X-ray in Diagnosing Lung Cancer in Smokers With Chest Symptoms Who Are Older Than 60 Years June 2011
NCT00419731 Unknown status Phase 2/Phase 3 Study of Bupropion Versus Bupropion + Naltrexone for Smoking Cessation November 2006 July 2010
NCT02776319 Unknown status N/A Effects of Non-invasive Brain Stimulation in Tobacco Use Disorder May 2016 December 2016
NCT01881841 Unknown status N/A Computer Adaptation of Screening, Brief MET Intervention to Reduce Teen Drinking January 2015 August 2017
NCT03788785 Unknown status N/A Smoking Tobacco Cessation Integrated Program of Patients Treated for the Head and the Neck Cancer February 2019 June 2022
NCT00429208 Unknown status N/A Effect Of Nicotine on Neurocognitive Performance of Cigarette Smokers February 2007 April 2007
NCT00865553 Unknown status Phase 2 Computer-Assisted Stop-Smoking Program in Helping Doctors Counsel Patients Who Smoke Cigarettes March 2009
NCT00000350 Unknown status Phase 1 Effects of Stimulant Dependence on Human Striatal Dopamine System - 15 March 1999
NCT00899262 Unknown status Biomarkers for Early Detection of Lung Cancer in Patients With Lung Cancer, Participants at High-Risk for Developing Lung Cancer, or Healthy Volunteers April 2008
NCT02004171 Withdrawn N/A Electronic Cigarettes or Nicotine Inhaler for Smoking Cessation December 2013 October 2015
NCT00781755 Withdrawn Phase 4 Treating Schizophrenic Smokers: Effects on Craving, Cues and Withdrawal
NCT05625685 Withdrawn N/A Equitable Smoking Relapse Prevention October 2, 2023 November 30, 2023
NCT02432066 Withdrawn Phase 2 Effects of GTS-21 on Smoking Behavior and Neurocognitive Functions September 29, 2018 December 29, 2020
NCT03497299 Withdrawn Phase 2 Combining rTMS With Varenicline to Prevent Smoking Lapse in Schizophrenia July 1, 2018 August 31, 2022
NCT04260776 Withdrawn Phase 1 Adaptive Treatment Strategies for Improving Engagement With a Web-Based Smoking Intervention in Socially Anxious Smokers April 15, 2022 December 31, 2024
MeSH unique ID (MeSH (Medical Subject Headings))
D014029