Huntington disease

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Information
Disease name
Huntington disease
Disease ID
Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT04556656 Active, not recruiting Phase 3 PRidopidine's Outcome On Function in Huntington Disease, PROOF- HD October 16, 2020 March 14, 2024
NCT02728115 Active, not recruiting Phase 1 Safety Evaluation of Cellavita HD Administered Intravenously in Participants With Huntington's Disease October 16, 2017 December 31, 2023
NCT04270604 Active, not recruiting Biological Sample Collection for Research and Biobanking February 6, 2012 January 2030
NCT00051324 Active, not recruiting Neurobiological Predictors of Huntington's Disease (PREDICT-HD) August 2002 June 30, 2024
NCT04219241 Active, not recruiting Phase 2/Phase 3 Clinical Extension Study for Safety and Efficacy Evaluation of Cellavita-HD Administration in Huntington's Patients. February 10, 2020 December 2022
NCT05769972 Active, not recruiting N/A Efficacy of Cognitive Rehabilitation Using Virtual Reality and Computer-based Cognitive Stimulation on Cognitive Impairment Associated to Movement Disorders October 13, 2021 December 1, 2023
NCT06391619 Active, not recruiting Huntington's Disease Young Adult Study 2.0 April 6, 2022 December 1, 2025
NCT04406636 Active, not recruiting Natural History Study in Huntington Disease Gene Expansion Carriers (HDGECs) - SHIELD HD May 19, 2020 April 2023
NCT06209515 Active, not recruiting Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register Study January 1, 2022 December 31, 2027
NCT05541627 Active, not recruiting Phase 1/Phase 2 A Study to Evaluate AB-1001 Striatal Administration in Adults With Early Manifest Huntington's Disease October 12, 2022 December 31, 2029
NCT00592995 Completed Phase 2 Creatine Safety and Tolerability in Premanifest HD: PRECREST December 2007 September 2012
NCT00632645 Completed Phase 3 Neuroleptic and Huntington Disease Comparison of : Olanzapine, la Tetrabenazine and Tiapride April 2009 April 28, 2017
NCT00654563 Completed Memory Disorders Registry August 2007 March 2012
NCT00724048 Completed Phase 2 A Study of Pridopidine (ACR16) for the Treatment of Participants With Huntington's Disease October 24, 2008 July 26, 2010
NCT00788047 Completed Phase 1 A Phase 1 Study To Evaluate The Effect Of Dimebon On The Pharmacokinetics Of Dextromethorphan November 2008 January 2009
NCT00831506 Completed Phase 1 Dimebon (PF-01913539)-Digoxin Drug-Drug Interaction Study In Healthy Subjects February 2009 May 2009
NCT00870974 Completed Phase 1 A PET Brain Imaging Study of mGluR5 in Subjects With Neuropsychiatric Conditions March 2009 November 2016
NCT00920946 Completed Phase 3 A Safety and Efficacy Study of Dimebon in Patients With Huntington Disease July 2009
NCT00970229 Completed Phase 1 Evaluation of [123I]MNI-420 and SPECT as a Marker of the Adenosine A2a Receptor in PD, HD and Healthy Subjects. July 2009 May 2015
NCT00980694 Completed Phase 1 Bioavailability of Ubiquinol in Huntington Disease September 2009 July 2012
NCT00988624 Completed Phase 1 A Study In Healthy Volunteers To Estimate The Pharmacokinetics Of Four Modified-Release Formulations Of Dimebon (Latrepirdine) October 2009 December 2009
NCT01306929 Completed Phase 2 Open-label Extension Study of Pridopidine (ACR16) in the Symptomatic Treatment of Huntington Disease March 24, 2011 January 5, 2018
NCT01339130 Completed N/A Assessment of Social-emotional Functioning in Neurological Diseases June 2009 June 2013
NCT01357681 Completed Phase 2 Effects of EGCG (Epigallocatechin Gallate) in Huntington's Disease (ETON-Study) September 2011 May 2015
NCT01359774 Completed N/A 31P-MRS and Huntington Disease April 2011 April 2012
NCT05748288 Completed Development of the Virtual Unified Huntington's Disease Rating Scale September 22, 2022 May 2, 2023
NCT01458470 Completed Phase 2 A Trial of Memantine as Symptomatic Treatment for Early Huntington Disease September 2011 November 2012
NCT01485952 Completed Phase 1 An Exploratory Clinical Trial in Early Stage Huntington's Disease Patients With SEN0014196 March 2011 November 2011
NCT01573819 Completed Phase 1 A Repeat Dose Study in Healthy Volunteers Investigating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK356278 November 24, 2011 April 2, 2012
NCT01590589 Completed REGISTRY - an Observational Study of the European Huntington's Disease Network (EHDN) June 2004 June 30, 2017
NCT01590888 Completed Phase 2 Effect of PBT2 in Patients With Early to Mid Stage Huntington Disease April 2012 February 2014
NCT01602900 Completed Phase 1 Healthy Volunteer Positron Emission Tomography (PET) Brain Occupancy Study of a Phosphodiesterase 4 (PDE4) Inhibitor in Huntington's Disease November 22, 2011 April 12, 2012
NCT01696708 Completed N/A Utilization of 31P-Nuclear Magnetic Resonance Spectroscopy to Monitor Brain Energy Deficit in Huntington Disease December 6, 2012 November 2015
NCT01834911 Completed Phase 4 Effect of Tetrabenazine on Stroop Interference in HD March 2013 January 1, 2018
NCT01842919 Completed N/A Dance and Huntington Disease April 2013 July 8, 2016
NCT01882062 Completed Phase 2 Proof of Concept of an Anaplerotic Study Using Brain Phosphorus Magnetic Resonance Spectroscopy in Huntington Disease May 2013 July 2013
NCT01884181 Completed Accelerated Diffusion MRI for Diagnosis of Hungtington Disease January 2014 December 2017
NCT01919034 Completed Evaluating the Relationship of Morphine Consumption and Pain-related Molecules in Hepatic Surgical Patients April 2012 December 2012
NCT01937923 Completed A Pre-Cellular Therapy Observational Study in Early Huntington's Disease August 2013 July 2016
NCT05358821 Completed Phase 2 28-Day Study of SAGE-718 on Functioning Capacity in Participants With Huntington's Disease June 22, 2022 April 10, 2024
NCT02268617 Completed N/A Treadmill Walking in Individuals With Dementia With Lewy Bodies and Huntington's Disease February 2013 September 2016
NCT02336633 Completed N/A Resveratrol and Huntington Disease July 2015 January 2020
NCT02453061 Completed Phase 2 A Comparative Phase 2 Study Assessing the Efficacy of Triheptanoin, an Anaplerotic Therapy in Huntington's Disease June 29, 2015 December 3, 2019
NCT02464293 Completed N/A A Pilot Evaluation of Mindfulness-based Cognitive Therapy for People With Huntington's Disease June 2015 January 31, 2018
NCT02535884 Completed N/A Deep Brain Stimulation (DBS) of the Globus Pallidus (GP) in Huntington's Disease (HD) July 2014 December 31, 2021
NCT05268029 Completed Making HD Voices Heard March 23, 2022 October 11, 2023
NCT02727270 Completed Measuring Cortisol Levels in Persons With Parkinson's (PD) June 2016 November 16, 2023
NCT02814201 Completed Study of Motor Slowing in Parkinson's Disease by a Computerized Mental Chronometry Paradigm July 2011 November 2016
NCT02819700 Completed Evaluation and Characterization of Behavioural Disorders and Dementias by the Behavioural Dysexecutive Syndrome Inventory (BDSI) January 29, 2013 January 28, 2018
NCT05250323 Completed Energy Balance in Huntington's Disease. A Multidisciplinary Study Approach for a Complex Problem (BEHD-EM) May 14, 2021 June 23, 2021
NCT05238701 Completed Phase 1 A Dose-escalation Study to Evaluate the Safety, Tolerability and Pharmacokinetic of LPM3770164 in Healthy Subjects February 25, 2022 November 4, 2023
NCT05224115 Completed Dosimetry of [11C]CHDI-180R and [11C]CHDI-626. July 17, 2020 October 13, 2020
NCT05157074 Completed N/A Group Drum-Based Music Therapy Intervention for Parkinson's Disease/Huntington's Disease January 9, 2019 June 10, 2019
NCT05126862 Completed N/A Measurement and Modification of Threat Interpretation Bias in Neurodegenerative Movement Disorders (Aims 2 & 3) December 10, 2021 July 9, 2023
NCT04925622 Completed Complex Eye Movements in Parkinson's Disease and Related Movement Disorders January 4, 2021 April 15, 2022
NCT03193099 Completed N/A Decoding Presymptomatic White Matter Changes in Huntington Disease July 11, 2017 December 30, 2019
NCT04917133 Completed N/A Adapted Physical Activity Effect on Abilities and Quality of Life of Huntington Patients and Relatives During Rehab Stay June 7, 2021 December 7, 2021
NCT03252535 Completed Phase 2 Dose-response Evaluation of the Cellavita HD Product in Patients With Huntington's Disease January 15, 2018 April 30, 2021
NCT04701580 Completed N/A Synaptic Density and Progression of Huntington's Disease. January 14, 2020 October 5, 2022
NCT04630574 Completed Characterization and Quantification of Motor Speech Disorders in Huntington's Disease: Identification of Acoustic Markers February 23, 2021 February 5, 2024
NCT03417583 Completed N/A Assessing Efficacy of Neuropsychiatric Assessment and Treatment Protocols in Huntington's Disease Patients November 9, 2018 October 10, 2023
NCT03421327 Completed Genetic Risk: Whether, When, and How to Tell Adolescents September 1, 2017 December 31, 2018
NCT04201834 Completed Phase 2 Risperidone for the Treatment of Huntington's Disease Involuntary Movements August 13, 2020 December 30, 2023
NCT04515550 Completed Mitochondrial Biomarkers in Huntington's Disease April 4, 2019 February 28, 2022
NCT03709173 Completed FuRST 2.0 Cognitive Pre-testing - Round 2 August 2, 2019 October 25, 2019
NCT04514367 Completed Phase 2 An Open Label Study of ANX005 in Subjects With, or at Risk for, Manifest Huntington's Disease August 17, 2020 January 28, 2022
NCT04421339 Completed N/A Melatonin for Huntington's Disease (HD) Gene Carriers With HD Related Sleep Disturbance - a Pilot Study January 22, 2021 September 16, 2022
NCT03787758 Completed Phase 1 A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of SAGE-718 Oral Solution in Patients With Huntington's Disease - Part B February 28, 2019 October 7, 2019
NCT03842969 Completed Phase 3 An Open-Label Extension Study to Evaluate Long-Term Safety and Tolerability of RO7234292 (RG6042) in Huntington's Disease Participants Who Participated in Prior Roche and Genentech Sponsored Studies April 23, 2019 March 30, 2022
NCT03854019 Completed Phase 3 Evaluating the Efficacy of Dextromethorphan/Quinidine in Treating Irritability in Huntington's Disease August 5, 2019 November 11, 2022
NCT03515213 Completed Phase 2 Safety and Efficacy of Fenofibrate as a Treatment for Huntington's Disease April 27, 2017 August 31, 2021
NCT00075140 Completed Family Health After Predictive Huntington Disease (HD) Testing September 2001 October 2008
NCT00146211 Completed Phase 3 TREND-HD - A Trial of Ethyl-EPA (Miraxion™) in Treating Mild to Moderate Huntington's Disease September 2005 July 2007
NCT00190450 Completed Phase 2 MIG-HD: Multicentric Intracerebral Grafting in Huntington's Disease January 2002 December 2013
NCT00271596 Completed Phase 2 Citalopram to Enhance Cognition in HD November 2005 November 2011
NCT00277355 Completed Phase 2/Phase 3 Pilot Study of Minocycline in Huntington's Disease April 2006 November 2008
NCT00277602 Completed Phase 3 Riluzole in Huntington's Disease November 1999 July 2004
NCT00368849 Completed Phase 2 Atomoxetine and Huntington's Disease November 2005 February 2008
NCT00465790 Completed Research of Biomarkers in Parkinson Disease October 2007 June 2012
NCT00539747 Completed Making Sense of a Positive Genetic Test Result for Huntington Disease October 1, 2007 August 5, 2008
NCT05668520 Enrolling by invitation A Pilot Study of Nutritional Status in Patients With Huntington's Disease October 1, 2022 October 2023
NCT05913154 Enrolling by invitation Impact of Apathy on Caregiving in HD. Version 1 April 26, 2023 December 2023
NCT06448546 Not yet recruiting Gut Microbiomes in HD June 2024 June 2029
NCT05360082 Not yet recruiting Comparison Between [11C]UCB-J and [18F]SynVest-1 PET in HD. September 2024 December 2025
NCT05509153 Not yet recruiting Phase 2 A Randomised Controlled Trial, Of N-Acetyl Cysteine (NAC), for Premanifest Huntingtin Gene Expansion Carriers November 1, 2022 May 1, 2027
NCT06097780 Not yet recruiting Phase 3 Efficacy and Safety of NestaCell® in Huntington's Disease June 8, 2024 February 9, 2026
NCT06147414 Not yet recruiting Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders April 2024 December 2026
NCT06194006 Not yet recruiting N/A Long Term Follow-up Grafted Huntington's Disease Patients January 1, 2024 January 1, 2034
NCT06444217 Not yet recruiting N/A Gene Therapy Development and Validation for Huntington's Disease Fibro TG-HD July 1, 2024 July 1, 2028
NCT05828992 Recruiting Benchmarking Integrated Care for People Living With Huntington's Disease in England February 28, 2023 February 29, 2024
NCT04394767 Recruiting Couple and Spouse Caregiver in Huntington's Disease January 13, 2020 February 2025
NCT04478734 Recruiting Phase 2 Trial of the Combined Use of Thiamine and Biotin in Patients With Huntington's Disease April 12, 2023 December 30, 2025
NCT03434548 Recruiting iMarkHD: In Vivo Longitudinal Imaging of HD Pathology July 20, 2021 June 30, 2027
NCT04713982 Recruiting Phase 2/Phase 3 Impact of Deutetrabenazine on Functional Speech and Gait Dynamics in Huntington Disease November 19, 2021 April 1, 2025
NCT04818060 Recruiting Preparing for Prevention of Huntington's Disease (PREVENT-HD) September 13, 2021 February 2026
NCT04826692 Recruiting Phase 3 TEsting METformin Against Cognitive Decline in HD December 10, 2021 August 2024
NCT03233646 Recruiting Retinal Imaging in Neurodegenerative Disease July 20, 2017 December 31, 2025
NCT05032196 Recruiting Phase 1/Phase 2 Study of WVE-003 in Patients With Huntington's Disease September 6, 2021 December 2024
NCT03034122 Recruiting Is Caffeine an Environmental Modifier in Huntington's Disease? October 11, 2017 October 2023
NCT02994719 Recruiting Gait Analysis in Neurological Disease March 1, 2016 June 20, 2025
NCT05243017 Recruiting Phase 1/Phase 2 Safety and Efficacy of AMT-130 in European Adults With Early Manifest Huntington's Disease October 7, 2021 October 7, 2029
NCT05270681 Recruiting N/A Move to Improve: Telehealth Exercise to Music for HD November 8, 2021 December 2024
NCT05326451 Recruiting N/A Home-based Transcranial Direct Current Stimulation Open Trial for Behavioral and Cognitive Symptoms in Huntington's Disease June 21, 2023 May 1, 2024
NCT05358717 Recruiting Phase 2 A Study to Evaluate the Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD) April 25, 2022 July 31, 2024
NCT06254482 Recruiting Phase 2 An Extension Study to Evaluate the Long-Term Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD) August 25, 2023 July 20, 2027
NCT06343220 Recruiting Project AWARE 2.0 to Improve Awareness, Willingness and Ability for Research and Enrollment in Clinical Research April 10, 2024 September 2024
NCT05534139 Recruiting Clinicopathological MRI and CSF Correlates in Huntington's Disease. August 11, 2021 August 31, 2024
NCT05655520 Recruiting Phase 3 A Study to Evaluate the Safety and Tolerability of SAGE-718 in Participants With Huntington's Disease December 14, 2022 December 2025
NCT05686551 Recruiting Phase 2 GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease. February 3, 2023 April 1, 2027
NCT05773196 Recruiting Prospective Single-Timepoint Huntington's Disease Biospecimen Collection Study March 14, 2023 February 28, 2025
NCT05808153 Recruiting N/A Innovative Imaging and Cognitive BIOmarkers to Predict Huntington's Disease Progression March 21, 2024 February 2, 2027
NCT05822908 Recruiting Phase 1/Phase 2 A Safety and Pharmacokinetics Trial of VO659 in SCA1, SCA3 and HD February 14, 2023 September 15, 2025
NCT05943054 Recruiting N/A Striatum and Hippocampus on Different Time Scales January 6, 2023 March 30, 2026
NCT06024265 Recruiting Early Phase 1 The Safety and Tolerability Study With ER2001 Intravenous Injection in Adults With Early Manifest Huntington's Disease April 4, 2023 December 31, 2024
NCT06082713 Recruiting Extracellular Vesicles for HD October 25, 2023 November 2031
NCT06414967 Recruiting N/A Study to Evaluate Music Therapy on Irritability and Impulsivity in Patients With Huntington's Disease (MUSIC-HD) May 15, 2024 May 20, 2026
NCT06203106 Recruiting NYSCF Scientific Discovery Biobank November 10, 2022 November 10, 2045
NCT06216054 Recruiting Phase 1 Safety, Tolerability and Pharmacokinetic of Multiple-ascending Doses of LPM3770164 in Healthy Subjects December 23, 2023 August 14, 2024
NCT04071639 Recruiting Phase 1 Symptomatic Therapy for Patients With Huntington's Disease March 12, 2020 December 31, 2024
NCT04012411 Recruiting N/A Study of BDNF Pathway Biomarkers in the Cerebrospinal Fluid in Patients With Huntington's Disease March 3, 2020 February 2026
NCT04231487 Recruiting Using Wearable and Mobile Data to Diagnose and Monitor Movement Disorders June 27, 2019 December 31, 2022
NCT04244513 Recruiting N/A Deep Brain Stimulation Treatment for Chorea in Huntington's Disease February 1, 2020 December 30, 2023
NCT03810898 Terminated Early Phase 1 iMagemHTT: FIH Evaluation of Novel Mutant Huntingtin PET Radioligands [¹¹C]CHDI-00485180-R and [¹¹C]CHDI-00485626 February 9, 2021 February 15, 2023
NCT02907294 Terminated Phase 1 Study to Assess the Safety, Tolerability and Pharmacokinetic Profile of PBF-999 "After Multiple Oral Doses" in Healthy Volunteers March 2016 May 2016
NCT04617847 Terminated Phase 1/Phase 2 Open-label Extension Study to Evaluate the Safety and Tolerability of WVE-120101 in Patients With Huntington's Disease April 13, 2020 May 3, 2021
NCT04617860 Terminated Phase 1/Phase 2 Open-label Extension Study to Evaluate the Safety and Tolerability of WVE-120102 in Patients With Huntington's Disease September 24, 2019 April 29, 2021
NCT03052712 Terminated N/A Validation and Standardization of a Battery Evaluation of the Socio-emotional Functions in Various Neurological Pathologies September 9, 2016 September 8, 2019
NCT03886753 Terminated Pharmacokinetic (PK) and Pharmacodynamics (PD) Study of Ilera Specific Products May 15, 2019 June 30, 2020
NCT02218567 Terminated N/A Behavioural Problems in Huntington Disease : Analysis and Enhancement of Caregiver and Patient Experience June 2014 December 2015
NCT03980938 Terminated Phase 2 Within Subject Crossover Study of Cognitive Effects of Neflamapimod in Early-Stage Huntington Disease July 8, 2019 October 15, 2020
NCT01085266 Terminated Phase 3 An Extension of the HORIZON Protocol Evaluating the Safety of Dimebon (Latrepirdine) in Subjects With Huntington Disease February 2010
NCT03344601 Unknown status N/A PHysical Activity and Exercise Outcomes in Huntington's Disease February 16, 2018 August 31, 2020
NCT04698551 Unknown status NIPD on cffDNA for Triplet Repeat Diseases September 1, 2020 December 1, 2023
NCT03296176 Unknown status N/A Metabolomic Study in Huntington's Disease (METABO-HD) October 9, 2017 September 2019
NCT04301726 Unknown status Phase 1 Efficacy of Deutetrabenazine to Control Symptoms of Dysphagia Associated With HD September 1, 2020 December 31, 2022
NCT00675077 Unknown status Phase 1 Far Infrared Irradiation for Managing, Control and Treatment of Huntington's Disease (HD) May 2008 June 2010
NCT01834053 Unknown status Phase 1/Phase 2 Safety and Efficacy of Bone Marrow Derived MNCs for Treatment of Cells for the Treatment of Hunting Tons Chorea. September 2014 June 2016
NCT00052143 Unknown status Prospective Huntington At Risk Observational Study July 1999 July 2010
NCT03119246 Unknown status N/A Beta Testing of a New Assessment in Huntington's Disease (HD) June 2016 March 2018
NCT01554033 Unknown status Study of Huntington Patients in Connection With European Huntington's Disease Network (EHDN) May 2009 May 2015
NCT05225051 Unknown status N/A N- Homocysteinylated Huntingtin in Huntington's Disease April 1, 2022 May 1, 2023
NCT01412125 Unknown status Study of Biomarkers That Predict the Evolution of Huntington's Disease September 2003 January 2021
NCT04257513 Unknown status Clinical Study to Monitor Plasma Levels of 24OHC in Subject With HD October 1, 2019 September 2022
NCT04370470 Unknown status Development of Assessments for Later Stage HD September 2020 March 2022
NCT00514774 Unknown status Phase 1 Ursodiol in Huntington's Disease August 2007 June 2009
NCT03764215 Unknown status Phase 1 Nilotinib in Huntington's Disease November 15, 2018 November 30, 2020
NCT04429230 Unknown status N/A Non-invasive Brain Stimulation in Huntington's Disease September 7, 2021 December 31, 2022
NCT00313495 Unknown status Cooperative Huntington's Observational Research Trial February 2006 December 2020
NCT03713892 Unknown status Phase 1 CKD-504 in SAD and MAD in Healthy Korean and Caucasian Adult Male and Female Subjects May 23, 2018 December 2020
NCT03599076 Unknown status Wearable Sensors for Quantitative Assessment of Motor Impairment in Huntington's Disease Huntington's Disease September 25, 2018 December 2019
NCT04589182 Unknown status N/A Assessing the Symptomatic Benefit of Acoustic Slow Wave Enhancement in Parkinson Disease October 20, 2020 October 31, 2022
NCT02563418 Unknown status N/A Feasibility of a Video-oculography in Patients With Huntington's Disease VOG-HD Study May 2014
NCT04885114 Withdrawn Phase 1 Safety and Tolerability Study With VY-HTT01, in Adults With Early Manifesting Huntington's Disease July 30, 2021 December 30, 2024
NCT03142217 Withdrawn N/A Characterization of the Profile of Dysarthria in Huntington's Disease, Using the Clinical Evaluation Battery of Dysarthria March 26, 2015 March 1, 2017
OrphaNumber from OrphaNet (Orphanet)
399
ICD10 preferred id (Insert disease from ICD10)
D0005261
ICD10 class code (Insert disease from ICD10)
G10
MeSH unique ID (MeSH (Medical Subject Headings))
D006816