essential hypertension

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Information
Disease name
essential hypertension
Disease ID
DOID:10825
Description
"A hypertension with no known cause. It is the most common type of hypertension." [url:http\://en.wikipedia.org/wiki/Essential_hypertension, url:http\://www.merckmanuals.com/professional/cardiovascular_disorders/hypertension/overview_of_hypertension.html]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT05385770 Active, not recruiting Phase 3 Study to Evaluate and Compare the Efficacy and Safety of AZM and AML Combined and Alone in Mild-to-moderate Essential Hypertensive Subjects May 31, 2022 November 30, 2024
NCT05912322 Active, not recruiting N/A Evaluation of Black Chokeberry Bio Juice on Blood Pressure Levels and Endothelial Damage June 1, 2022 September 30, 2023
NCT05257291 Active, not recruiting Phase 2 Study MIPAE - Melatonin and Essential Arterial Hypertension February 2, 2018 August 2024
NCT05843682 Active, not recruiting N/A Technological Innovation in the Virtual Assistance of Patients With Uncontrolled Arterial Hypertension - Hyper 2 October 7, 2022 February 29, 2024
NCT00151827 Completed Phase 3 Olmesartan Medoxomil in Hypertension and Renal Impairment August 2003 July 2005
NCT00157963 Completed Phase 4 Hydrochlorothiazide (+) Losartan Potassium vs. Amlodipine Comparative Study (0954A-314) February 5, 2005 February 8, 2006
NCT00185172 Completed Phase 3 Olmesartan in Essential Hypertension January 2002 June 2005
NCT00185185 Completed Phase 3 Olmesartan Medoxomil in Atherosclerosis November 2001 February 2006
NCT00220220 Completed Phase 3 Amlodipine as add-on to Olmesartan in Hypertension April 2005 April 2007
NCT00220233 Completed Phase 3 Olmesartan as an add-on to Amlodipine in Hypertension April 2005 August 2007
NCT00254475 Completed Phase 3 A Study to Evaluate the Efficacy of Valsartan/Simvastatin Combinations in Patients With Both Essential Hypertension and Hypercholesterolemia November 2005 September 2006
NCT00286884 Completed Heart Rate Variability in White Coat Hypertension and Essential Hypertension
NCT00288184 Completed Phase 2 Uric Acid in Essential Hypertension in Children September 2004 August 2007
NCT00295555 Completed Phase 4 Doxazosin Effects on ABPM in Hypertensive Patients With Diabetic Nephropathy January 2004 April 2007
NCT00298129 Completed Autonomic Imbalance and 24-h Blood Pressure Change in Patients With Chronic Renal Disease February 2004 December 2006
NCT00311155 Completed Phase 4 Olmesartan and an add-on Treatment in Patients With Mild to Moderate Hypertension March 2006 April 2008
NCT00328965 Completed Phase 4 Lacidipine In Mild To Moderate Essential Hypertension Patients With Type 2 Diabetes In Korea November 2004 May 2006
NCT00343551 Completed Phase 3 Efficacy and Safety of Aliskiren 300mg Compared to Irbesartan 300mg and Ramipril 10 mg in the Setting of a Missed Dose for Patients With Essential Hypertension. May 2006
NCT00408512 Completed Phase 4 Pharmacosurveillance and Pharmacogenetics of First-line Diuretics in Hypertension: The StayOnDiur Study December 2006 March 2010
NCT00415038 Completed Phase 2 Efficacy of Rostafuroxin in the Treatment of Essential Hypertension February 2005 August 2007
NCT00425373 Completed Phase 2/Phase 3 Efficacy and Safety of Valsartan and Amlodipine in Patients With Essential Hypertension November 2006 March 2008
NCT00430508 Completed Phase 3 Use of the Combination of Olmesartan and Hydrochlorothiazide in Essential Hypertension February 2007 May 2008
NCT00430950 Completed Phase 3 Combination of Olmesartan and Hydrochlorothiazide in Essential Hypertension February 2007 October 2008
NCT00437645 Completed Phase 3 Efficacy and Safety of Valsartan/Amlodipine Compared to Amlodipine in Patients With Essential Hypertension January 2007 November 2007
NCT00438945 Completed Phase 4 The Effect of Eprosartan on Hormones and Kidney Function in Patients With Essential Hypertension January 2007 January 2008
NCT00461903 Completed Phase 3 Efficacy of Perindopril to Prevent Recurrence of Atrial Fibrillation in Patients With Essential Hypertension December 2007 September 2015
NCT00500786 Completed Phase 1/Phase 2 Safety, Tolerability, Pharmacodynamic Effects and Preliminary Evidence for Efficacy of the Anti-Hypertension Vaccine CYT006-AngQb November 2004 April 2007
NCT00509470 Completed Phase 4 Evaluation of Effect of Combination With Telmisartan and Hydrochlorothiazide in Hypertensives Uncontrolled on Amlodipine July 2007 October 2012
NCT00553865 Completed Phase 2 Clinical Trial to Evaluate the Efficacy and the Safety of Antihypertensive Tablets November 2007 November 2008
NCT00607633 Completed Candesartan and Candesartan/ Hydrochlorothiazide in the Treatment of Patients With Hypertension and LVH January 2007 October 2007
NCT00608153 Completed Compliance of Patients With Essential Hypertension Treated With Candesartan or Candesartan/Hydrochlorothiazide January 2007 September 2007
NCT00654875 Completed Phase 4 Efficacy and Safety of Once Daily Dosing of Aliskiren (300 mg (qd) Once a Day) to Twice Daily Dosing of Aliskiren (150 mg (Bid) Twice a Day) in Treating Moderate Hypertension. March 2008 November 2008
NCT03991442 Completed Phase 3 BR1010 in Patients With Essential Hypertension Patients Who do Not Adequately Respond to Fimasartan/Amlodipine Combination June 17, 2019 March 2, 2021
NCT00137124 Completed Phase 2/Phase 3 L-Arginine Metabolism in Essential Hypertension May 2006 December 2009
NCT00138944 Completed Phase 3 Effectiveness of Eplerenone to Improve Target Organ Damage in Patients With Resistant Arterial Hypertension January 2007 July 2008
NCT00139698 Completed Phase 3 Olmesartan Alone or in Combination With Hydrochlorothiazide in Subjects With Mild to Moderate Essential Hypertension September 2005 July 2006
NCT01631227 Completed Phase 3 Comparison of the Effect of Eprosartan and Eprosartan Mesylate on Blood Pressure in Essential Hypertension June 2012 April 2013
NCT01663233 Completed Phase 3 Efficacy and Safety of LCZ696 200 mg + Amlodipine 5 mg in Comparison With Amlodipine 5 mg in Hypertensive Patients Not Responding to Amlodipine August 2012 May 2013
NCT01667614 Completed Phase 2 Effects of Spironolactone Combination Therapy on Proteinuria, Kidney Function, and Blood Pressure May 2010 July 2012
NCT01679652 Completed Phase 2 The Effects of Nebivolol on the NO-system in Patients With Essential Hypertension August 2012 September 2013
NCT01701726 Completed Phase 3 Effect of Acupuncture on Patients With Mild Hypertension July 2012 April 2016
NCT01785472 Completed Phase 3 Efficacy and Safety of LCZ696 in Comparison to Olmesartan in Asian Patients With Essential Hypertension April 2013 August 2014
NCT01838850 Completed Phase 3 Efficacy and Safety Study of Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide Combination Therapy in Patients With Hypertension Not Controlled With Olmesartan Medoxomil and Hydrochlorothiazide Combination Therapy April 2013 August 2014
NCT01842230 Completed Phase 1 Study to Investigate the Effect of Atorvastatin on the Pharmacokinetic Properties of Telmisartan/S-amlodipine April 2013 July 2013
NCT01842256 Completed Phase 1 Study to Investigate the Effect of Telmisartan/S-amlodipine on the Pharmacokinetic Properties of Atorvastatin. April 2013 July 2013
NCT01873885 Completed Phase 1 Phase 1, Randomized, Double-Blind, Placebo-Controlled Exploratory Study That Will Assess the Safety, Tolerability, Pharmacokinetics and Hemodynamic Response to a Single 30 Minute Intravenous Infusion of Vasomera™ (PB1046) in Adult Subjects With Stage 1 or 2 Essential Hypertension June 2013 March 2014
NCT01878201 Completed Phase 2 A Valsartan 80 Mg-Referenced, Therapeutic Exploratory Clinical Study to Evaluate the Antihypertensive Efficacy of Fimasartan 30 mg During 24 Hours in Patients With Mild to Moderate Essential Hypertension May 2013 February 2014
NCT01900171 Completed Phase 1 Phase I Study in Healthy Male Subjects Comparing QGC001 to Placebo February 2012 May 2012
NCT01900184 Completed Phase 1 Study of the Product QGC001 as a Single Dose and Multiple Doses Administered Orally to Healthy Adult Subjects December 2012 March 2013
NCT02031861 Completed Phase 4 Efficacy Study of Nifedipine Controlled-Release Tablets (Xin Ran) to Treat Mild to Moderate Essential Hypertension February 2014 July 2014
NCT02058446 Completed Phase 4 PMS Study of Amlodipine/Valsartan for the Treatment of Hypertension October 2013 March 2014
NCT02062645 Completed Phase 4 Study of Efficacy and Safety of CVAA489 in Hypertensive Patients February 2014 September 2015
NCT02152306 Completed Phase 3 Fimasartan/Amlodipine Combination Phase III April 2014 July 2015
NCT02277691 Completed Phase 3 A Phase III Long-term Study of TAK-536TCH in Participants With Essential Hypertension November 7, 2014 April 25, 2016
NCT02322450 Completed Phase 2 Phase IIa Study of the Product QGC001 Compared With Placebo in Patients With Essential Hypertension January 2015 April 2016
NCT02345044 Completed Phase 2 A Study to Evaluate Efficacy and Safety of CS-3150 in Japanese Hypertensive Subjects January 2015 October 2015
NCT02368652 Completed Phase 3 A Study to Evaluate the Efficacy and Safety of Amlodipine Besylate and Candesartan Cilexetil in Essential Hypertension Patient Who Are Not Adequately Controlled With Candesartan Cilexetil Monotherapy December 2014 November 2015
NCT02368665 Completed Phase 3 A Study to Evaluate the Efficacy and Safety of Amlodipine Besylate and Candesartan Cilexetil in Essential Hypertension Patient Who Are Not Adequately Controlled With Amlodipine Besylate Monotherapy December 2014 November 2016
NCT02385721 Completed Post-Authorization Long-term Safety Surveillance on Antihypertensive Treatment With Kanarb® (Fimasartan) May 2013 April 2018
NCT02412761 Completed N/A Series of N-of-1 Crossover Trials of Antihypertensive Therapy in Adolescents With Essential Hypertension June 2013 July 2016
NCT02419235 Completed Phase 2 The Effect of a Homoeopathic Complex on Blood Pressure in Refractory Hypertension October 2014 March 2015
NCT02449811 Completed RAS Peptide Profiles in Patients With Arterial Hypertension April 2015 November 2018
NCT02480764 Completed Phase 3 Azilsartan Medoxomil (TAK-491) Compared to Valsartan in Chinese Participants With Hypertension August 27, 2015 October 13, 2017
NCT02517866 Completed Phase 4 Azilsartan Medoxomil in the Treatment of Essential Hypertension and Type 2 Diabetes in Asia July 13, 2015 November 25, 2016
NCT02553512 Completed Helius in Hypertension-I: The UK Hypertension Registry September 2013 May 2015
NCT02579356 Completed Phase 1 To Evaluate the Drug-drug Interaction Between Telmisartan and Atorvastatin in Healthy Male Volunteers May 2014 August 2014
NCT02603809 Completed Phase 2 Dose-finding Study With ACT-132577 (Aprocitentan) in Participants With Essential Hypertension December 14, 2015 April 7, 2017
NCT02612298 Completed Phase 4 Efficacy and Safety of Arotinolol Hydrochloride on Morning Blood Pressure and Heart Rate August 2015 September 13, 2018
NCT02687178 Completed Phase 4 Canrenone as Add-on in Patients With Essential Hypertension October 2010 January 2016
NCT02722265 Completed Phase 3 Long-term Study of CS-3150 as Monotherapy or in Combination With Other Antihypertensive Drug in Japanese Patients With Essential Hypertension March 2016 July 8, 2017
NCT02738632 Completed Phase 3 Efficacy and Safety of TAH Combination in Comparison With Telmisartan/Amlodipine Combination for Essential Hypertension Patients May 2015 August 2016
NCT02822222 Completed Phase 1/Phase 2 Safety Study of RMJH-111b to Treat Essential Hypertension June 10, 2016 July 7, 2016
NCT02839382 Completed N/A The Northwest Coalition for Primary Care Practice Support May 1, 2015 May 1, 2018
NCT02848170 Completed N/A Study of CS-3150 Compared to Olmesartan in Patients With Essential Hypertension August 2016 April 2017
NCT02890173 Completed Phase 3 Study of CS-3150 in Patients With Essential Hypertension September 2016 July 11, 2017
NCT02938910 Completed Study of Myocardial Interstitial Fibrosis in Hyperaldosteronism November 2012 October 2014
NCT02944734 Completed Phase 2 Comparison of Efficacy and Safety of Combination Therapy and Monotherapy of Candesartan and Amlodipine for Dose-Finding in Patients With Essential Hypertension September 2014 December 2015
NCT03156842 Completed Phase 3 Combination of Fimasartan/Amlodipine/Rosuvastatin in Patients With Essential Hypertension and Dyslipidemia May 29, 2017 December 7, 2018
NCT03371797 Completed Amlodipine VaLsartan Efficacy in Hypertensive Patients.A Real World Trial February 20, 2018 November 5, 2018
NCT03514641 Completed Phase 2/Phase 3 An Integrated Assessment of the Safety and Effectiveness of Bexagliflozin for the Management of Essential Hypertension October 18, 2017 November 30, 2018
NCT03649646 Completed FimasaRtan-basEd BP Targets After Drug SwitcHing July 3, 2018 October 29, 2020
NCT03803306 Completed N/A Vedic Medical Astrology in Essential Hypertension July 12, 2018 January 6, 2019
NCT03847350 Completed Observational Study of Efficacy and Safety of Nebivolol in Korean Patients With Essential Hypertension July 1, 2015 March 23, 2017
NCT03924115 Completed N/A Evaluation of a Transmedial Psychoeducational Program to Improve Pharmacological Adherence October 10, 2017 April 1, 2019
NCT00026065 Completed Phase 1 Hypertension: Prediction of Biofeedback Success February 2000 March 2006
NCT04151537 Completed N/A Personal Activity Intelligence in the Treatment of High Blood Pressure October 21, 2019 May 19, 2020
NCT04303689 Completed N/A Repurposing Colchicine to Improve Vascular Function in Hypertension August 1, 2020 February 28, 2023
NCT04470817 Completed A Study for PMS of AZL-M in the Treatment of Adult Participants With Essential Hypertension in South Korea August 7, 2018 May 25, 2023
NCT04470830 Completed A Study for PMS of AZL-M/CLD FDC in the Treatment of Participants With Essential HTN in South Korea September 11, 2019 May 25, 2023
NCT04488978 Completed Phase 2 Phase 2 Study to Evaluate the Efficacy and Safety of Irbesartan and Amlodipine Combined or Alone in Patients With Essential Hypetension May 21, 2020 November 9, 2021
NCT05288400 Completed Phase 3 Evaluation of the Clinical Efficacy and Safety of Amlodipine 5mg/ Bisoprolol Fumarate 5mg /Perindopril Arginine 5mg Fixed-dose Combination in Capsule and Free Monotherapy at the Same Dose in Patients With Uncontrolled Essential Hypertension. May 14, 2018 December 18, 2018
NCT05359068 Completed Phase 3 Study to Evaluate the Efficacy and Safety of SPH3127 In Patients With Mild-moderate Essential Hypertension June 10, 2021 December 26, 2023
NCT05390931 Completed N/A Effect of Motivational Interviews on Cardiovascular Disease Risks and Healthy Lifestyle Behavior Changes August 1, 2022 March 31, 2023
NCT05475665 Completed Phase 3 Clinical Efficacy and Safety Evaluation of Irbesartan High and Amlodipine Combined Therapy in Essential Hypertension Patients July 14, 2022 June 13, 2023
NCT05476120 Completed N/A The Effect of the Use of BATHE Interview Technique on Treatment Compliance in Hypertension Patients in Primary Care October 1, 2020 April 30, 2021
NCT05476354 Completed Phase 3 Clinical Efficacy and Safety Evaluation of Irbesartan and Amlodipine Combined Therapy in Essential Hypertension Patients July 5, 2022 June 13, 2023
NCT05684666 Completed N/A Effect of Breathing and Muscle Relaxation Technique in Individual With Essential Hypertension February 21, 2019 October 26, 2019
NCT05931224 Completed Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of D064 and D702 Combination Therapy June 28, 2023 May 13, 2024
NCT05987436 Completed Effect of Aerobic Exercise in Patients With Essential Hypertension November 1, 2017 December 1, 2019
NCT05993806 Completed Phase 1 A Bioequivalence Study of L04TD3 Compared to Administration of L04RD1 in Healthy Volunteers June 2, 2023 June 29, 2023
NCT06121518 Completed Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of D064 and D702 Combination Therapy Versus D064 or D702 Monotherapy July 31, 2023 March 26, 2024
NCT06184269 Completed Phase 1 A Study to Evaluate the Pharmacokinetics and the Safety After Administration of "BR1017-1" and Co-administration of "BR1017-1A" and "BR1017-1B" December 23, 2023 February 18, 2024
NCT06212648 Completed Phase 2 Evaluate the Efficacy and Safety of SPC1001 and Monotherapy in Patients With Essential Hypertension March 25, 2022 January 27, 2023
NCT06226727 Completed Phase 1 A Study to Evaluate the Pharmacokinetics and the Safety After Administration of "BR1019" and Co-administration of "BR1019-1" and "BR1019-2" February 14, 2024 March 31, 2024
NCT06395194 Completed Phase 3 Effects of Valsartan vs Amlodipine and Low BP on Kidney Outcomes in Essential Hypertension September 27, 1997 December 5, 2003
NCT06465264 Completed Phase 3 To Assess Allisartan Isoproxil/Amlodipine Tablets in Patients With Essential Hypertension Uncontrolled With Amlodipine or Allisartan Isoproxil April 29, 2021 February 24, 2023
NCT00667719 Completed Phase 3 A Long Term Safety Study to Test the Combination of Aliskiren/ Amlodipine / Hydrochlorothiazide in Participants With Essential Hypertension June 5, 2008 October 5, 2009
NCT00709930 Completed Phase 2 Efficacy and Safety of Weak Extremely Low Frequency Electromagnetic Fields in Mild and Moderate Essential Hypertension December 2007 December 2008
NCT00741585 Completed Phase 4 Prognostic Value of the Circadian Pattern of Ambulatory Blood Pressure for Multiple Risk Assessment September 1, 2008 June 30, 2018
NCT00751751 Completed Phase 3 Olmesartan Medoxomil Versus Losartan in Elderly and Very Elderly June 2003 June 2005
NCT00758524 Completed Phase 2 A Study to Evaluate Efficacy and Safety of LCI699 in Participants With Essential Hypertension September 11, 2008 July 2, 2009
NCT00802542 Completed In-practice Evaluation of Atacand 16mg Antihypertensive Effect November 2008 January 2009
NCT00818883 Completed Phase 3 Efficacy and Safety of Azilsartan Medoxomil and Chlorthalidone in Participants With Moderate to Severe Hypertension February 2009 November 2009
NCT00846365 Completed Phase 3 Efficacy and Safety of Azilsartan Medoxomil Plus Chlorthalidone in Participants With Moderate to Severe Hypertension March 2009 June 2010
NCT00856271 Completed Phase 3 Olmesartan Medoxomil Versus Losartan Potassium in Patients With Mild to Moderate Essential Hypertension August 2004 April 2005
NCT00857285 Completed Phase 3 Olmesartan Medoxomil Versus Losartan in Patients With Hypertension May 2002 September 2003
NCT00872586 Completed Phase 3 Evaluation of the Additional Efficacy, and Safety of Olmesartan Medoxomil 20mg / Hydrochlorothiazide 12.5mg in the Treatment of Chinese Patients With Mild to Moderate Essential Hypertension August 2006 August 2007
NCT00890591 Completed Phase 4 Efficacy and Safety of Olmesartan Medoxomil in Stage 1 and 2 Essential Hypertension August 2006 August 2007
NCT00902538 Completed Phase 3 Hydrochlorothiazide as add-on to Olmesartan/Amlodipine in Hypertension April 2009 October 2010
NCT00922441 Completed Phase 2 A Therapeutic Exploratory Clinical Study to Evaluate the Antihypertensive Efficacy of Fimasartan (BR-A-657•K) During 24 Hours in Patients With Mild to Moderate Essential Hypertension December 2008 August 2009
NCT00923091 Completed Phase 3 Parallel-Group Comparison of Olmesartan (OLM), Amlodipine (AML) and Hydrochlorothiazid (HCTZ) in Hypertension June 2009 March 2011
NCT00923533 Completed Phase 1 A Study to Evaluate the Safety and Pharmacokinetics After Oral Concurrent Administration of Fimasartan and Hydrochlorothiazide in Healthy Male Volunteers March 2009 August 2009
NCT00937534 Completed Phase 1 Study to Compare and Assess the Safety and Pharmacokinetic Characteristics After Oral Administration of Fimasartan (BR-A-657∙K) in Healthy Elderly and Young Male Volunteers January 2009 August 2009
NCT00937651 Completed Phase 2 Efficacy, Safety and Pharmacodynamic/Pharmacokinetic Study of Fimasartan (BR-A-657•K) April 2005 June 2006
NCT00938132 Completed Phase 1 A Clinical Trial to Evaluate the Effect of Fimarsartan on Pharmacodynamics, Pharmacokinetics, and the Safety of Warfarin in Healthy Male Volunteers July 2009 September 2009
NCT00938197 Completed Phase 1 A Study to Evaluate the Pharmacokinetic Drug Interaction After Oral Concurrent Administration of Fimasartan and Amlodipine in Healthy Male Volunteers June 2009 August 2009
NCT00938262 Completed Phase 1 A Study to Evaluate the Effect of Ketoconazole and Rifampicin on the Pharmacokinetics of Fimasartan in Healthy Male Volunteers April 2009 August 2009
NCT00991705 Completed Phase 1 A Study to Evaluate the Effect of Atorvastatin on the Pharmacokinetics of Fimasartan in Healthy Male Volunteers July 2009 September 2009
NCT00991783 Completed Phase 1 A Study to Evaluate the Effect of Fimasartan on Pharmacokinetics, and the Safety of Digoxin in Healthy Male Volunteers August 2009 November 2009
NCT00996281 Completed Phase 3 Safety and Tolerability of Azilsartan Medoxomil Plus Chlorthalidone Compared to Olmesartan Medoxomil Plus Hydrochlorothiazide in Participants With Essential Hypertension October 2009 November 2011
NCT01001572 Completed Phase 3 Efficacy and Safety of Valsartan/Amlodipine in Patients With Mild to Moderate Essential Hypertension September 2009 May 2010
NCT01012687 Completed N/A Bioequivalency Study of Perindopril Erbumine 8 mg Tablet Under Fasted Conditions April 2007 May 2007
NCT01013155 Completed N/A Bioequivalency Study of Perindopril Erbumine 8 mg Tablet Under Fed Conditions May 2007 May 2007
NCT01022515 Completed Specificity of Elevated Plasma EM66 Levels in Pheochromocytoma November 2008 December 2013
NCT01033071 Completed Phase 3 Efficacy and Safety of Azilsartan Medoxomil and Chlorthalidone Compared to Olmesartan Medoxomil and Hydrochlorothiazide in Participants With Moderate to Severe Hypertension. January 2010 November 2010
NCT01042392 Completed Phase 4 Efficacy of Aliskiren Compared to Ramipril in the Treatment of Moderate Systolic Hypertensive Patients November 2009 January 2011
NCT01083017 Completed Resistant Arterial Hypertension Cohort Study April 2011 May 2017
NCT01093807 Completed Phase 2 Efficacy and Safety of Lercanidipine and Enalapril in Patients With Essential Hypertension March 2010 April 2011
NCT01113047 Completed Phase 3 Aliskiren in Combination With Amlodipine in Hypertensive Patients Not Responding to Angiotensin Receptor Blocker (ARB) Plus Amlodipine May 2010
NCT01120990 Completed Phase 4 Hybrid Blood Pressure Monitor Validation April 2010 July 2010
NCT01122251 Completed Phase 2 Efficacy and Safety of Lercanidipine and Valsartan in Patients With Essential Hypertension December 2009 July 2010
NCT01127139 Completed Effectiveness and Patient Self-assessed Compliance of Blood Pressure Treatment With Tarka® Fixed Combination in Patients With Essential Hypertension April 2010 March 2011
NCT01131546 Completed Phase 4 Efficacy and Safety of Levamlodipine Besylate Compared to Amlodipine Maleate in Patients With Essential Hypertension December 2009 March 2011
NCT01146938 Completed Phase 1 A Clinical Trial to Compare and Evaluate the Pharmacokinetic Characteristics and the Safety of Fimasartan in Hepatic Impairment Patients and Healthy Volunteers May 2010 February 2011
NCT01180413 Completed Phase 4 Intensive Vasodilator Therapy in Patients With Essential Hypertension December 2010 April 2012
NCT01195805 Completed N/A The Effects of Amiloride and Spironolactone on Renophysiological and Cardiovascular Variables August 2010 August 2015
NCT01198249 Completed Phase 1 Pharmacokinetic Drug Interactions Between Single and Concomitant Administrations of Amlodipine, Losartan, and Hydrochlorothiazide in Subjects With (Pre)Hypertension September 2010 March 2011
NCT01237223 Completed Phase 3 Efficacy and Safety of SPA100 (Fixed-dose Combination of Aliskiren/Amlodipine) in Patients With Essential Hypertension October 2010 May 2011
NCT01237873 Completed Phase 3 Long Term Safety of SPA100 (Fixed-dose Combination of Aliskiren/Amlodipine) in Patients With Essential Hypertension January 2011 February 2012
NCT01256411 Completed Phase 2 A Long-term (12 Months) Safety, Tolerability and Efficacy Study of LCZ696 in Patients With Essential Hypertension November 2010 April 2012
NCT01258673 Completed Phase 3 A Clinical Study to Evaluate Efficacy and Safety of Fimasartan/Hydrochlorothiazide Combination-therapy November 2010
NCT01264692 Completed Phase 2 Essential Hypertension February 2011 February 2012
NCT01289132 Completed Phase 2 Efficacy and Safety of Azilsartan in Participants With Mild to Moderate Uncomplicated Essential Hypertension July 2007 July 2008
NCT01289886 Completed Phase 1 Fimasartan (BR-A-657) Single Oral Dose in Healthy Subjects September 2003 December 2003
NCT01289899 Completed Phase 1 Fimasartan (BR-A-657) Multiple Oral Dose in Healthy Subjects January 2004 February 2004
NCT01295021 Completed The Prevalence of Sympathetic Overactivity in Primary Hypertensive Patients. February 2011 February 2012
NCT01342614 Completed N/A The Effect of Metformin on the Correlation Between Hyperinsulinemia and Hypertension May 2006 August 2009
NCT01456169 Completed Phase 3 A Study to Evaluate the Effectiveness and Safety of a Fixed Dose Combination of Azilsartan Medoxomil and Chlorthalidone in Patients With High Blood Pressure Who do Not Achieve Target Blood Pressure Following Treatment With Azilsartan Medoxomil Alone October 2011 January 2013
NCT01523067 Completed Phase 1 Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Response of Vasomera (PB1046) Injection Following a Single Subcutaneous Dose in Subjects With Stage 1 or 2 Essential Hypertension January 2012 December 2012
NCT01541943 Completed Phase 3 Efficacy and Safety of HL-040XC in Essential Hypertension and Hyperlipidemia March 2012 November 2014
NCT01556997 Completed Phase 3 Perindopril Amlodipine for the Treatment of Hypertension February 2012 February 2013
NCT01566188 Completed N/A Vascular Impact of Omega-3 in Metabolic Syndrome January 2011 January 2014
NCT01599104 Completed Phase 3 Efficacy and Safety of LCZ696 in Comparison to Olmesartan in Japanese Patients With Essential Hypertension June 2012 April 2013
NCT01615198 Completed Phase 3 Efficacy and Safety of LCZ696 in Comparison to Olmesartan in Elderly Patients With Essential Hypertension August 2012 July 2013
NCT06141200 Not yet recruiting Phase 3 NW Roselle in Grade 1 Essential Hypertension: Phase III Clinical Trial March 2024 April 2025
NCT06235554 Not yet recruiting N/A Feasibility Study Evaluating the Safety and Efficacy of the Renal Stimulation by Direct Wire Pacing, During Renal Denervation Procedure February 20, 2024 July 1, 2024
NCT06441630 Not yet recruiting Phase 3 A Study to Evaluate the Efficacy and Safety of Co-administration of AD-227A and AD-227B June 17, 2024 January 31, 2025
NCT05843162 Not yet recruiting Phase 4 A Clinical Trial to Evaluate the Blood Pressure Control of Telmisartan or Losartan in Essential Hypertensive Patients With Metabolic Syndrome June 1, 2023 December 31, 2023
NCT05503953 Not yet recruiting Phase 3 Phase III Study to Evaluate the Efficacy and Safety of AGSAVI in Patients With Essential Hypertension Inadequately Controlled With AGLS September 5, 2022 July 31, 2024
NCT05880056 Not yet recruiting Phase 4 Study of Bisoprolol (Nerkardou - Nerhadou International) 5 and 10 mg Oral Dissolvable Film (ODF) Treatment in Egyptian Patients With Essential Hypertension May 21, 2024 April 1, 2025
NCT06287580 Not yet recruiting Early Phase 1 Effects of Antihypertensive Drug Treatment on Brain Blood Flow, Cognition, and Regulation of Nervous System in Older Adults With Hypertension. May 15, 2024 January 1, 2027
NCT06091176 Not yet recruiting N/A Assessment of Efficacy and Safety of Amicomed®, for the Management of Essential Hypertension November 1, 2024 October 31, 2025
NCT06041529 Not yet recruiting Phase 4 Study to Evaluate the Efficacy and Safety of TEL/AML/CTD in Elderly Patients With Essential Hypertension September 14, 2023 June 27, 2025
NCT06418074 Not yet recruiting N/A Effects of Exogenous Ketosis on Renal Function, Renal Perfusion, and Sodium Excretory Capacity September 2024 December 2025
NCT05526703 Recruiting Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of D064 and D701 Combination Therapy September 28, 2022 October 2023
NCT05573477 Recruiting Phase 3 Evaluation of Efficacy and Safety of ATB-1011+ATB-1012 Co-administration for Essential Hypertension and Type II Diabetes November 16, 2022 June 2024
NCT05638269 Recruiting A Multicentre Study on Features of the Gut Microbiota of Patients With Critical Chronic Diseases in China March 1, 2022 December 2025
NCT06220773 Recruiting Phase 3 A Study to Evaluate the Efficacy and Safety of BR1019A and BR1019B Combination Therapy May 21, 2024 April 2025
NCT06090617 Recruiting Water and Electrolytes Content in HYpertension (WHYSKI) in the SKIn January 1, 2021 January 1, 2025
NCT05910242 Recruiting N/A Efficacy and Safety of Remote Ischemic Conditioning in the Treatment of Essential Hypertension (RICBP-EH) June 20, 2023 March 1, 2024
NCT05092672 Recruiting N/A Physical Activity, Air Pollution, and High Blood Pressure November 15, 2021 October 1, 2023
NCT05930028 Recruiting Phase 3 A Study to Evaluate the Efficacy and Safety of BR1017A and BR1017B Combination Therapy in Essential Hypertension Patients With Primary Hypercholesterolemia July 13, 2023 June 2024
NCT03857490 Recruiting N/A Heat Therapy in Older Hypertensive Women July 29, 2019 February 2025
NCT05900713 Recruiting N/A Effect of DNS Exercises Training on Hypertension July 1, 2023 May 30, 2024
NCT06130124 Recruiting S-amlodipine in Essential HypertensIon and Assessment of Blood Pressure Targets Achievement February 22, 2023 July 25, 2025
NCT05947448 Recruiting Efficacy and Safety of Mexartan Potassium Tablets (AZL-M) and Calcium Channel Blockers (CCB) in the Treatment of Adults With Essential Hypertension in Chinese Population: a National Multicenter, Prospective, Observational Study January 22, 2024 December 31, 2025
NCT06165250 Recruiting Phase 3 A Study to Evaluate the Efficacy and Safety of Co-administrated BR1018B and BR1018C April 17, 2024 April 2025
NCT06416865 Recruiting Phase 3 Efficacy and Safety of AJU-C52 in Essential Hypertension Patients June 27, 2022 August 31, 2024
NCT03945305 Recruiting N/A Safety and Efficacy of Remote Ischemic Conditioning Treatment for Community-based Essential Hypertension November 1, 2023 April 28, 2024
NCT05845905 Recruiting N/A Effects of Remote Ischemic Conditioning on Blood Pressure in Older Patients With Hypertension May 10, 2023 April 20, 2024
NCT05878561 Recruiting Phase 3 A Study to Evaluate the Efficacy and Safety of BR1015 Combination Therapy November 9, 2022 October 2024
NCT06282549 Recruiting Study to Evaluate the Efficacy and Safety of TEL/AML/CTD in Elderly Patients With Essential Hypertension June 8, 2022 March 31, 2027
NCT06084065 Recruiting N/A Feasibility and Effectiveness of a Ring-type Blood Pressure Measurement Device July 13, 2023 December 31, 2024
NCT01132768 Terminated Phase 4 The Confirmatory Olmesartan Plaque Regression Study May 2010 June 2011
NCT00791986 Terminated N/A Loaded Breathing Training in Essential Hypertension May 2006 December 2008
NCT00208104 Terminated N/A Motivational Interviewing July 2002 September 2008
NCT01938911 Terminated N/A The Effects of Social Support and Oxytocin Administration on Physiological Stress Reactivity in Essential Hypertension November 2014 June 2016
NCT03226340 Unknown status Phase 4 S-amlodipine+Chlorthalidone vs S-amlodipine+Telmisartan in Hypertension December 2, 2015 March 31, 2018
NCT01629225 Unknown status Phase 4 GRK4 Polymorphisms Blood Pressure Response to Candesartan July 2013 July 2015
NCT03566654 Unknown status Phase 2 Clinical Trial on Remote Ischemic Conditioning and Hypertension（HOPE） August 30, 2018 December 2019
NCT00716950 Unknown status Phase 4 Valsartan and Amlodipine Compared to Losartan and Amlodipine in Hypertensive Patients July 2008 February 2009
NCT03708601 Unknown status Prognostic Risk of Patients With Essential Hypertension for Cardiovascular Events (PROSPECT) September 8, 2016 August 8, 2022
NCT01819870 Unknown status Phase 1 Study to Compare the Pharmacokinetic Characteristics and Safety of Dilatrend SR Capsule 32mg and Dilatrend Tablet 25mg April 2013 August 2013
NCT00841308 Unknown status Phase 4 Home Blood Pressure in Hypertension Management February 2009 December 2012
NCT01825759 Unknown status Phase 4 Danshen Dropping Pill for Coronary Heart Disease Heart and Artery Structure and Function January 2013 December 2014
NCT03885843 Unknown status N/A Sympathetic Mapping/ Ablation of Renal Nerves Trial (SMART) HTN-OFF MED Study June 1, 2019 April 1, 2020
NCT01848873 Unknown status Phase 2/Phase 3 Efficacy of Amlodipine-folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine January 2013 August 2013
NCT03928158 Unknown status Phase 2 LCZ696 in Advanced LV Hypertrophy and HFpEF May 31, 2019 November 30, 2022
NCT01956786 Unknown status Phase 2/Phase 3 Efficacy of Amlodipine-Folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine September 2013 February 2014
NCT04306627 Unknown status Phase 4 Effect of Atorvastatin on Carotid Intima Media Thickness April 15, 2020 February 28, 2021
NCT02059616 Unknown status Phase 2 A Phase 2 Dose Selection Trial of Candesartan Cilexetil and Amlodipine Besylate to Treat Essential Hypertension February 2014 December 2015
NCT04460300 Unknown status N/A Effects of Aromatherapy in Hypertensive Individuals December 3, 2018 August 3, 2020
NCT00994617 Unknown status Phase 4 Monotherapy Versus Dual Therapy for Initial Treatment for Hypertension January 2010 December 2014
NCT02136264 Unknown status N/A Study of Personalized Dietary Intervention for the Control of Essential Hypertension June 2013 June 2018
NCT01011660 Unknown status Phase 4 Effects of Angiotensin II Receptor Blocker Compared With Diuretics in High-risk Hypertensive Patients October 2007 December 2012
NCT02206165 Unknown status Phase 2 A Dose Selection Trial of CKD-330 in Patients With Essential Hypertension March 2014 June 2015
NCT02214498 Unknown status Phase 4 Treatment of HYpertension: Morning Versus Evening May 2015 May 2017
NCT02277821 Unknown status N/A Evaluation of Stendo Pulsating Suit on Microcirculation and Central Blood Pressure in Essential Hypertension Patients October 2014 July 2015
NCT04554303 Unknown status Comparing Safety and Efficacy of Amlodipine Verses S Amlodipine in Patients With Essential Hypertension October 28, 2020 May 23, 2022
NCT02357615 Unknown status Phase 4 Efficacy Study of Nifedipine Controlled-Release Tablets (Xin Ran) to Treat Early Morning Blood Pressure and Central Arterial Pressure December 2014 September 2015
NCT05033535 Unknown status Phase 2 s086 Tablets in the Treatment of Mild to Moderate Essential Hypertension July 1, 2020 June 30, 2022
NCT05103813 Unknown status Early Phase 1 Protective Effect of Beraprost Sodium Tablets on Reperfusion Therapy for Acute STEMI May 1, 2022 June 30, 2023
NCT02407210 Unknown status Phase 3 Efficacy and Safety of Azilsartan Compared to Olmesartan Medoxomil in Chinese Participants With Grade I or II Essential Hypertension January 2015
NCT05109013 Unknown status Juvenile Essential Arterial Hypertension and Vascular Function September 1, 2021 December 31, 2023
NCT00644475 Unknown status Phase 3 Imidapril and Candesartan on Fibrinolysis and Insulin-Sensitivity in Patients With Mild to Moderate Hypertension March 2008 March 2009
NCT00380289 Unknown status N/A Early Metabolic Changes With Thiazide or Beta Blocker Therapy for Essential Hypertension September 2006
NCT01320397 Unknown status Phase 2 Antihypertensive Effect of Rostafuroxin Compared With Losartan in Hypertensive Patients Bearing Specified Gene Mutations May 2011 December 2012
NCT01413048 Unknown status Phase 3 Clinical Trial to Evaluate the Antihypertensive Effect of AGSCT101 in Patient With Hypertension January 2011 September 2012
NCT01417221 Unknown status N/A Renal Sympathetic Modification in Patients With Essential Hypertension August 2011 December 2020
NCT00366119 Unknown status Phase 4 Safety and Efficacy of Ramipril in the Treatment of Essential Hypertension June 2006 June 2007
NCT03063697 Unknown status Observational Study to Evaluate the Safety of DILATREND SR Cap. in Korean Patients With Essential Hypertension, Chronic Stable Angina and Congestive Heart Failure November 2015 December 2020
NCT00659451 Unknown status Phase 3 Effects Of Losartan On Myocardial Structure In Diabetic Hypertensive Patients With Left Ventricular April 2008 April 2009
NCT01617551 Unknown status N/A Effect of Renal Denervation on NO-mediated Sodium Excretion and Plasma Levels of Vasoactive Hormones March 2012 June 2014
NCT02096939 Withdrawn Microvascular Function in Primary Aldosteronism September 2014 April 2016
Disase is a (Disease Ontology)
DOID:10763
Cross Reference ID (Disease Ontology)
ICD10CM:I10
Cross Reference ID (Disease Ontology)
ICD9CM:401
Cross Reference ID (Disease Ontology)
MESH:D000075222
Cross Reference ID (Disease Ontology)
MIM:145500
Cross Reference ID (Disease Ontology)
MIM:603918
Cross Reference ID (Disease Ontology)
MIM:604329
Cross Reference ID (Disease Ontology)
MIM:607329
Cross Reference ID (Disease Ontology)
MIM:608742
Cross Reference ID (Disease Ontology)
MIM:610261
Cross Reference ID (Disease Ontology)
MIM:610262
Cross Reference ID (Disease Ontology)
MIM:610948
Cross Reference ID (Disease Ontology)
MIM:611014
Cross Reference ID (Disease Ontology)
NCI:C3478
Cross Reference ID (Disease Ontology)
ORDO:243761
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:194757006
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0085580
Exact Synonym (Disease Ontology)
idiopathic hypertension
Exact Synonym (Disease Ontology)
primary hypertension
MedGen concept unique identifier (MedGen Concept name)
C0085580
MedGen unique identifier (MedGen Concept name)
88442
MeSH unique ID (MeSH (Medical Subject Headings))
D000075222