optic neuritis
Information
- Disease name
- optic neuritis
- Disease ID
- DOID:1210
- Description
- "An optic nerve disease that results_in inflammation located_in optic nerve which may cause a complete or partial loss of vision." [url:https\://www.mayoclinic.org/diseases-conditions/optic-neuritis/symptoms-causes/syc-20354953] {comment="sn:IEDB"}
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT00445367 | Active, not recruiting | Biobank For MS And Other Demyelinating Diseases | May 2006 | October 2036 | |
| NCT03963310 | Active, not recruiting | Optical Coherence Tomography and Optic Neuritis Not Related to Multiple Sclerosis | September 14, 2020 | September 14, 2024 | |
| NCT01424735 | Completed | N/A | TLR-9 Antagonism in Steroid Resistant Optic Neuritis | July 2006 | May 2010 |
| NCT00179478 | Completed | Phase 4 | Long Term Study of Avonex Therapy Following a First Attack of Multiple Sclerosis | February 2001 | March 2009 |
| NCT00355095 | Completed | Phase 2 | Safety and Efficacy Study of Erythropoietin as add-on Therapy of Methylprednisolone to Treat Acute Optic Neuritis | August 2006 | July 2011 |
| NCT00856635 | Completed | Phase 3 | A Randomized, Double-blind, Placebo-controlled, Multicenter Study of the Effects of Glatiramer Acetate (GA) on the Retinal Nerve Fiber Layer (RNFL) and Visual Function in Patients With a First Episode of Acute Optic Neuritis (AON). (Octagon) | February 2009 | February 2011 |
| NCT01274702 | Completed | Phase 2 | Visual Reconstitution Therapy After Optic Neuritis | May 2010 | March 2013 |
| NCT01294176 | Completed | Phase 1 | Lipoic Acid as a Treatment for Acute Optic Neuritis | January 2011 | November 2016 |
| NCT01337986 | Completed | Phase 2/Phase 3 | Ampyra for Optic Neuritis in Multiple Sclerosis | May 2011 | December 2013 |
| NCT00000117 | Completed | Phase 3 | Intravenous Immunoglobulin Therapy in Optic Neuritis | August 1995 | December 1997 |
| NCT01451593 | Completed | Phase 2 | Neuroprotection With Phenytoin in Optic Neuritis | November 2011 | March 2015 |
| NCT01524250 | Completed | Phase 2/Phase 3 | Optic Neuritis Recovery After Oral or IV Corticosteroids | March 2012 | May 2015 |
| NCT01774123 | Completed | Optical Coherence Tomography in Multiple Sclerosis Patients | August 2012 | June 2013 | |
| NCT01802489 | Completed | Phase 2 | Amiloride Clinical Trial In Optic Neuritis | February 2013 | November 2015 |
| NCT01962571 | Completed | Phase 3 | Treatment of Optic Neuritis With Erythropoietin: a Randomised, Double-blind, Placebo-controlled Trial | November 25, 2014 | November 26, 2019 |
| NCT01987167 | Completed | Early Phase 1 | Defining the Functional and Neuro-Protective Potential of ACTHAR in Acute Optic Neuritis | November 2013 | December 2016 |
| NCT02004054 | Completed | Interest of Dynamic Measures of the Pupil in Optic Neuritis | December 2012 | May 2013 | |
| NCT02864134 | Completed | Optic Neuritis and Ganglion Cell Layer | August 2016 | February 28, 2019 | |
| NCT02894281 | Completed | Pupillometry Dynamic Measures in Patients Without Ocular or Neurological Disease | June 2016 | June 30, 2017 | |
| NCT02939937 | Completed | Phase 2 | Effect of Phenytoin on the Ganglion Cell Layer in Patients With Optic Neuritis | March 9, 2017 | January 2, 2019 |
| NCT03345537 | Completed | Initial Clinical Presentation of Inflammatory Optic Neuritis Associated or Not With Autoantibodies Anti-Myelin-oligodendrocyte-glycoprotein | February 12, 2018 | March 31, 2022 | |
| NCT03451955 | Completed | N/A | The Effect of a Gluten Free Diet on the Permeability of the Blood Brain Barrier in Patients With CIS | January 19, 2018 | June 16, 2022 |
| NCT03570385 | Completed | N/A | Can Diffusion Tensor Imaging (DTI) of the Optic Ways Contributes to Predict the 6 Months Prognosis of Optic Neuritis (ON)? | December 4, 2017 | June 24, 2022 |
| NCT03630497 | Completed | Phase 1 | BN201 SAD MAD Study in Healthy Subjects | May 27, 2018 | February 22, 2019 |
| NCT03753893 | Completed | Ocular Manifestations in Rheumatic Diseases | May 1, 2013 | November 1, 2021 | |
| NCT04792866 | Completed | 3D FLAIR Versus Coronal T2-WI MRI in Detecting Optic Neuritis (FLACON) | January 1, 2018 | August 1, 2020 | |
| NCT04793087 | Completed | Post-COntrast 3D SE T1 Versus Coronal SE T1-WI MRI in Detecting Optic Neuritis (COCON) | January 1, 2018 | August 30, 2020 | |
| NCT06453694 | Not yet recruiting | Phase 2 | Efgartigimod for the Treatment of Acute Optic Neuritis | October 2024 | July 2027 |
| NCT06389968 | Not yet recruiting | N/A | Light Stimulation to Improve Visual Function After Optic Neuritis in Persons With Multiple Sclerosis | May 2, 2024 | December 31, 2025 |
| NCT05540262 | Recruiting | N/A | Edaravone in the Treatment of Aquaporin-4 Antibody-positive Optic Neuritis | January 15, 2022 | December 31, 2024 |
| NCT05017142 | Recruiting | Swiss Pediatric Inflammatory Brain Disease Registry (Swiss-Ped-IBrainD) | April 14, 2020 | January 1, 2071 | |
| NCT03370965 | Recruiting | N/A | Optic Neuritis Differential Diagnosis Study | June 7, 2019 | June 2025 |
| NCT05487989 | Recruiting | VIsual Pathways Model in Neuro-inflammatory Disorders | October 7, 2022 | November 2025 | |
| NCT05605951 | Recruiting | Acute Optic Neuritis Network: an International Study That Invesitages Subjects With a First-ever Episode of Acute Inflammation of the Optic Nerve | August 15, 2020 | December 31, 2025 | |
| NCT01623076 | Recruiting | The Longitudinal CONQUER Study of Rare Neuroimmunologic Disorders | June 2012 | June 2025 | |
| NCT04148781 | Recruiting | Early Phase 1 | Fampridine-SR and Optic Neuritis Recovery | March 22, 2022 | January 2024 |
| NCT04762017 | Recruiting | Phase 2 | OCS-05 in Patients With Acute Optic Neuritis | February 11, 2021 | March 31, 2024 |
| NCT02521311 | Recruiting | Phase 2 | Assessment of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis (ReCOVER) | February 28, 2017 | August 2024 |
| NCT00624468 | Terminated | Phase 2 | Atacicept in Subjects With Optic Neuritis | June 2008 | January 2011 |
| NCT01073813 | Terminated | Phase 2 | Neuroprotection and Repair in Optic Neuritis | February 2010 | January 2013 |
| NCT04131764 | Terminated | Diagnosis of ON With or Without MS or NMOSD | October 4, 2019 | September 6, 2022 | |
| NCT02976766 | Terminated | Phase 2 | Gypenosides Treatment for Optic Neuritis | February 4, 2017 | December 31, 2020 |
| NCT04289909 | Unknown status | N/A | Identification of Retinal Perivascular Inflammation in Patients With Multiple Sclerosis Using Adaptive Optics (RETIMUS) | March 2020 | October 2022 |
| NCT00000146 | Unknown status | Phase 3 | Optic Neuritis Treatment Trial (ONTT) | July 1988 | |
| NCT01465893 | Unknown status | Phase 2 | Effect of Vitamin D on Retinal Changes in Patient With Optic Neuritis by Optic Coherence Tomography | July 2011 | December 2012 |
| NCT04042363 | Unknown status | N/A | Effect of Transorbital Electrical STIMulation of Optic Nerve on Remyelination After an Acute Optic Neuritis | July 10, 2019 | July 2022 |
| NCT04942002 | Unknown status | Phase 2/Phase 3 | Retrobulbar Methylprednisolone as Adjunctive Treatment in Optic Neuritis Trial | June 15, 2021 | September 15, 2023 |
| NCT03302585 | Unknown status | Phase 2 | High-Dose Vitamin D Induction in Optic Neuritis | November 23, 2017 | April 2023 |
| NCT02886377 | Unknown status | The Correlation Between AQP-4 Ab and the Visual Function of Patients With Demyelinating ON at Onset | November 2013 | December 2016 | |
| NCT03401879 | Unknown status | N/A | Retinal Neuro-vascular Coupling in Patients With Multiple Sclerosis | February 1, 2018 | March 2023 |
| NCT00261326 | Unknown status | Phase 3 | Simvastatin Treatment of Patients With Acute Optic Neuritis | September 2006 | May 2011 |
| NCT05353413 | Unknown status | N/A | Diffusion Weighted Magnetic Resonance Imaging and the Optic Nerve Neuropathy. | January 1, 2020 | January 1, 2024 |
| NCT00000147 | Unknown status | N/A | Longitudinal Optic Neuritis Study (LONS) | July 1988 | |
| NCT04257734 | Unknown status | Epidemiologic and Clinical Characteristics of Optic Neuritis in China | May 1, 2020 | June 30, 2021 | |
| NCT03586557 | Unknown status | N/A | Effectiveness of Plasma Exchange in Treating With Severe Acute AQP4-Ab Positive Optic Neuritis | September 1, 2018 | December 31, 2021 |
| NCT03651362 | Unknown status | Linking Optic Nerve MRI and the Retinal Axonal Loss After Optic Neuritis | February 2016 | February 2019 | |
| NCT00037115 | Withdrawn | Phase 4 | Induction Therapy With a Single High Dose Bolus of Intravenous Methotrexate With Leucovorin Rescue, Prior to Initiation of AVONEX® Treatment, in Patients Presenting With a First Acute Demyelinating Event. | May 2002 | December 2002 |
- Disase is a (Disease Ontology)
- DOID:1891
- Cross Reference ID (Disease Ontology)
- GARD:7320
- Cross Reference ID (Disease Ontology)
- ICD10CM:H46
- Cross Reference ID (Disease Ontology)
- ICD9CM:377.3
- Cross Reference ID (Disease Ontology)
- MESH:D009902
- Cross Reference ID (Disease Ontology)
- NCI:C84950
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:194051001
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0029134
- HPO Human Phenotype ID (Human Phenotype Ontology)
- HP:0100653
- ICD10 preferred id (Insert disease from ICD10)
- D0006216
- ICD10 class code (Insert disease from ICD10)
- H46
- MeSH unique ID (MeSH (Medical Subject Headings))
- D009902