Lupus Erythematosus, Systemic

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Information
Disease name
Lupus Erythematosus, Systemic
Disease ID
Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT05141201 Active, not recruiting SAPHNELO Systemic Lupus Erythematosus Japan Post-Marketing Surveillance (PMS) December 21, 2021 November 30, 2025
NCT05289544 Active, not recruiting N/A Phone-Based Based Walk With Ease Program for Adults With Arthritis April 1, 2022 September 29, 2024
NCT05379725 Active, not recruiting N/A Mediterranean vs. High-Fermented-Food Diet Adherence on Inflammation in Lupus July 22, 2022 May 4, 2025
NCT02988661 Active, not recruiting N/A Women Empowered to Live With Lupus Study January 19, 2017 February 2025
NCT00025818 Completed Phase 3 Six Month Clinical Research Study for Patients With Moderate or Severe Dry Eye Syndrome May 2001 March 2003
NCT00036491 Completed Phase 1/Phase 2 Anti-CD20 in Systemic Lupus Erythematosus January 2001 January 2006
NCT00065806 Completed Phase 3 Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) September 2003 December 2009
NCT00071487 Completed Phase 2 Safety and Efficacy Study of LymphoStat-B (Belimumab) in Subjects With Systemic Lupus Erythematosus (SLE) October 2003 June 2006
NCT00076752 Completed Phase 2 Lymphocyte Depletion and Stem Cell Transplantation to Treat Severe Systemic Lupus Erythematosus January 30, 2004 October 15, 2013
NCT00094380 Completed Phase 1/Phase 2 Treating Systemic Lupus Erythematosus (SLE) Patients With CTLA4-IgG4m (RG2077) September 2004 January 2006
NCT00125307 Completed Phase 4 Tacrolimus for the Treatment of Systemic Lupus Erythematosus With Membranous Nephritis January 2004 February 2008
NCT00137969 Completed Phase 2/Phase 3 A Study to Evaluate the Safety of Rituximab Retreatment in Subjects With Systemic Lupus Erythematosus May 10, 2005 August 25, 2008
NCT05326841 Completed Phase 3 Effect of Cholecalciferol Supplementation on Disease Activity and Quality of Life of Systemic Lupus Erythematosus Patients . October 3, 2021 January 11, 2022
NCT03187743 Completed N/A Personalised Pharmacological Approach to the Tapering of Corticosteroid Doses in Systemic Lupus Patients Treated With Prednisone April 17, 2018 April 20, 2022
NCT03248518 Completed N/A Lessening the Impact of Fatigue in Inflammatory Rheumatic Diseases September 5, 2017 November 2, 2020
NCT00005778 Completed Phase 3 High-Dose Intravenous (IV) Cyclophosphamide Versus Monthly IV Cyclophosphamide January 2000 April 2006
NCT00004643 Completed Phase 2 Phase II Pilot Study of Cytarabine for Refractory Systemic Lupus Erythematosus February 1995
NCT03504540 Completed Comparison of Complement Factors and Genetic Polymorphisms of AMD Between Patients With Systemic Lupus Erythematosus (SLE) With and Without Retinal "Pseudo-drusen-like" Deposits: Case-control Study (PL-AMD) April 5, 2018 May 15, 2021
NCT03142711 Completed Validation of a Mobile Phone Based on EPRO Tool in Subjects With Systemic Lupus Erythematosus August 21, 2017 July 3, 2018
NCT03427151 Completed Phase 3 Study of Repeated Administration of a 200-mcg Dose of IPP-201101 Plus Standard of Care in Patients With Systemic Lupus Erythematosus February 27, 2018 February 5, 2019
NCT03161483 Completed Phase 2 A Study to Evaluate the Efficacy and Safety of CC-220 in Subjects With Active Systemic Lupus Erythematosus August 31, 2017 August 3, 2021
NCT03312335 Completed Phase 2 Low-dose Interleukin-2 for Treatment of Systemic Lupus Erythematosus August 8, 2018 December 23, 2019
NCT00391924 Completed Phase 2 Dehydroepiandrosterone Administration in Women With Systemic Lupus Erythematosus or Primary Sjögren's Syndrome May 2000 January 2003
NCT00392951 Completed Phase 1/Phase 2 Sirolimus for Autoimmune Disease of Blood Cells December 2006 February 2016
NCT05278663 Completed Phase 1/Phase 2 A Study to Assess the Safety, Tolerability, and Pharmacokinetics of E6742 in Systemic Lupus Erythematosus Participants April 14, 2022 September 4, 2023
NCT00563082 Completed Analyzing the Association of Gene Variants With Increased Risk of Coronary Heart Disease in Women With Systemic Lupus Erythematosus May 2000 August 2007
NCT00582465 Completed Study to Evaluate the Natural History of Osteoporosis in Children and Adolescents With Systemic Lupus Erythematosus July 21, 1999 July 9, 2004
NCT00611663 Completed Phase 2/Phase 3 Safety Study of Two Vaccine Strategies in Patients With Systemic Lupus Erythematosus May 2008 April 2016
NCT00624338 Completed Phase 2/Phase 3 Atacicept Phase 2/3 in Generalized Systemic Lupus Erythematosus (APRIL-SLE) January 2008 October 2012
NCT00657189 Completed Phase 2 A Study to Evaluate Safety and Tolerability of Subcutaneous Doses of MEDI-545 in Subjects With Lupus July 2008 May 2010
NCT00714116 Completed Phase 1 Study Evaluating The SBI-087 In Subjects With Systemic Lupus Erythematosus March 2009 September 2012
NCT00774852 Completed Phase 2 Abatacept and Cyclophosphamide Combination Therapy for Lupus Nephritis November 2008 June 2014
NCT01060410 Completed Exploration of Genotype Based Personalized Prescription of Cyclophosphamide in Systemic Lupus Erythematosus Treatment May 2010 June 2012
NCT01093911 Completed Phase 1 Safety Study of CDP7657 in Healthy Volunteers and Patients With Systemic Lupus Erythematosus (SLE) March 2010 December 2012
NCT04956484 Completed Phase 4 Belimumab In Early Systemic Lupus Erythematosus September 1, 2021 April 8, 2022
NCT01327352 Completed N/A Evaluation of the Influence of Food Regimen on Oshadi D Absorption April 2011 October 2011
NCT01405196 Completed Phase 2 Subcutaneous Treatment In Randomized Subjects To Evaluate Safety And Efficacy In Generalized Lupus Erythematosus December 2011 March 2014
NCT04925934 Completed Phase 2 Study of VIB7734 for the Treatment of Moderate to Severely Active SLE June 24, 2021 June 9, 2023
NCT01582880 Completed Phase 1/Phase 2 Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis March 2012 March 2014
NCT01597050 Completed Phase 2 Safety and Efficacy of Topical R333 in Patients With Discoid Lupus Erythematosus (DLE) and Systemic Lupus Erythematosus (SLE) Lesions August 2012 September 2013
NCT04776161 Completed N/A Medication Adherence Patterns in Rheumatic Diseases: A Behavioral Trial August 2, 2021 November 10, 2022
NCT01702740 Completed Phase 1 A Study of the Safety and Pharmacokinetics of CNTO 136 in Patients With Cutaneous Lupus Erythematosus and Systemic Lupus Erythematosus March 2007 October 2009
NCT01753193 Completed Phase 2 An Open-label Study to Evaluate the Long-term Safety of MEDI-546, for the Treatment of SLE, in Adults March 28, 2013 July 18, 2018
NCT01764594 Completed Phase 1 Safety Study of CDP7657 in Patients With Systemic Lupus Erythematosus January 2013 August 2014
NCT01838694 Completed Phase 1/Phase 2 Double-Blinded, Randomized, Placebo-Controlled Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Biochemical Activity of Intravenous Cpn10 Administration in Subjects With Mild to Moderate SLE. July 2013 August 2015
NCT01845740 Completed Phase 1 Phase Ib Study of SC Milatuzumab in SLE January 2007 June 2009
NCT01923415 Completed A Non-drug Study Profiling Cutaneous Lupus April 2013 August 2014
NCT01972568 Completed Phase 2 Efficacy and Safety of Atacicept in Systemic Lupus Erythematosus December 2013 September 2016
NCT02034344 Completed A Study of Skin and Systemic Biomarkers In Patients With Active Cutaneous Lupus Erythematosus And In Healthy Volunteers October 2013 May 2015
NCT04266860 Completed N/A Establishing Clinical Utility of a New Diagnostic Test for Rheumatology Patients March 1, 2012 March 1, 2013
NCT04098055 Completed N/A Effect of Insoles in Patients With Systemic Lupus Erythematosus November 2, 2019 February 2, 2022
NCT02162992 Completed Systemic Lupus Erythematous and Heart Conduction Disorders April 2014 April 2018
NCT02219269 Completed A Complex Contraception Registry June 2014 June 2015
NCT02284984 Completed Phase 2 Synergetic B-cell Immodulation in SLE March 2014 October 31, 2018
NCT02349061 Completed Phase 2 A Phase 2a, Efficacy and Safety Study of Ustekinumab in Systemic Lupus Erythematosus October 15, 2015 March 13, 2019
NCT03933943 Completed Phase 1 A Study of LY3361237 in Participants With Systemic Lupus Erythematosus May 21, 2019 February 15, 2021
NCT02437890 Completed Phase 2 A Phase II Study to Evaluate Safety and Efficacy of ALX-0061 in Subjects With Systemic Lupus Erythematosus July 2015 January 2018
NCT02504645 Completed Phase 3 A 52-Week, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Evaluate the Efficacy and Safety of a 200-mcg Dose of IPP-201101 Plus Standard of Care in Patients With Systemic Lupus Erythematosus March 2015 January 2018
NCT02537028 Completed Phase 1 MSC2364447C Phase 1b in Systemic Lupus Erythematosus November 30, 2015 October 4, 2016
NCT02625831 Completed Anti-ficolin-3 Autoantibodies in Lupus Nephritis November 2012 May 2014
NCT00005436 Completed Lupus Cohort--Thrombotic Events and Coronary Artery Disease September 1991 August 1996
NCT02655640 Completed The Impact of Illness Perceptions on Health Related Outcomes in Patients With Lupus and Systemic Sclerosis October 2015 March 2017
NCT03933839 Completed N/A Internet-Based Pain Coping Skills Training for Patients With Lupus May 20, 2019 April 22, 2020
NCT02732470 Completed N/A Effect of Qi Gong Training on Quality of Life in Patients With Systemic Lupus Erythematous (LuQi) April 25, 2016 October 31, 2018
NCT02799173 Completed N/A Determination of the RANKL/Osteoprotegerin Ratio in Patients With Systemic Lupus Erythematosus. Role in Osteoporosis and Cardiovascular Calcification April 15, 2011 July 1, 2015
NCT03896373 Completed Role of the Neonatal Fc Receptor for IgG in the Pathophysiology of Lupus April 17, 2019 October 18, 2020
NCT02875691 Completed Phase 2 Effect of Green Tea on Treatment of Lupus September 2015 March 2016
NCT03724916 Completed Phase 1 A Study to Evaluate the Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of TAK-079 in Combination With Standard Background Therapy in Participants With Moderate to Severe Systemic Lupus Erythematosus (SLE) November 26, 2018 November 4, 2021
NCT02922114 Completed N/A Comparison of the Clinical Examination and the Joint Ultrasonography in Lupus Patients September 2013 October 2015
NCT02953821 Completed Phase 4 Acthar Gel for Active Systemic Lupus Erythematosus (SLE) December 16, 2016 October 25, 2019
NCT03027674 Completed Early Phase 1 Topical 10 % Nifedipine Versus 5% Sildenafil in Secondary Raynaud August 2016 August 2016
NCT03687138 Completed Searching for Diagnostic/Prognostic Biomarkers in SLE With Renal Involvement by Proteomic Techniques June 15, 2018 February 28, 2022
NCT03063281 Completed Anti-ficolin-2 Autoantibodies in Lupus Nephritis November 2012 May 2015
NCT03098823 Completed Phase 4 A Crossover Study to Compare RAYOS to IR Prednisone to Improve Fatigue and Morning Symptoms for SLE September 12, 2017 June 15, 2020
NCT03103243 Completed N/A Pilot Study to Investigate Contemplative Intervention in Lupus Patients April 27, 2017 June 4, 2018
NCT05506033 Enrolling by invitation N/A Optimization of Glucocorticoid Taper Strategies for SLE-ITP August 15, 2022 December 1, 2025
NCT06087523 Enrolling by invitation Pulmonary Disease Among Patients With Systemic Lupus Erythematosus August 15, 2023 January 1, 2026
NCT02422875 Enrolling by invitation Comparative Autoantibody and Immunologic Cell Marker Study August 2012 August 2024
NCT04736953 Not yet recruiting Phase 2 Sirolimus Treatment Of Patients With SLE January 1, 2025 January 1, 2029
NCT06373991 Not yet recruiting Phase 1 A Study to Evaluate the Safety and Efficacy of ATHENA CAR-T in Subjects With Systemic Lupus Erythematosus July 24, 2024 April 30, 2027
NCT06445127 Recruiting N/A Evaluation of Patients With Lupus Nephritis Using Kidney MRI (Magnetic Resonance Imaging) May 7, 2024 May 17, 2026
NCT02653287 Recruiting N/A Lupus Intervention for Fatigue Trial May 1, 2019 December 2024
NCT03473912 Recruiting Meir Medical Center Rheumatologic Biobank April 16, 2018 November 2037
NCT03527472 Recruiting Phase 2 Memantine for the Treatment of Cognitive Impairment in Systemic Lupus Erythematosus August 23, 2018 December 2026
NCT03543839 Recruiting Phase 4 Trial of Belimumab in Early Lupus September 15, 2020 December 2026
NCT03747159 Recruiting Phase 3 Synergetic B-cell Immunomodulation in SLE - 2nd Study. October 1, 2018 September 2025
NCT03917797 Recruiting Phase 2 Mesenchymal Stromal Cells (MSC´s) in Renal Lupus April 2, 2019 December 2025
NCT04895241 Recruiting Phase 3 A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus May 25, 2021 September 12, 2025
NCT04961567 Recruiting Phase 3 A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus July 16, 2021 March 5, 2026
NCT05193591 Recruiting Anti-C1s, Anti-HMGB1 and Anti-C1q Autoantibodies in Systemic Lupus Erythematosus (DYSALARM-322) January 20, 2022 October 31, 2025
NCT05261529 Recruiting N/A Effects of an Intervention With EVOO and Physical Activity in Patients With Systemic Lupus Erythematosus November 3, 2021 June 30, 2023
NCT05590390 Recruiting Osteoporosis and Fragility Fractures Among SLE Patients. (FRAIL Trial) December 31, 2022 December 30, 2023
NCT05607368 Recruiting Mast Cells Are Involved in the Mechanism of NPSLE Epilepsy January 1, 2022 December 31, 2025
NCT05636670 Recruiting Assessment of Cognitive Function and Gut Microbiota Analysis in Real World Patients With Lupus Cerebrovascular Disease October 1, 2022 September 30, 2024
NCT05648500 Recruiting Phase 3 A Research Study to Evaluate the Effects of a New Oral Medicine Called Cenerimod in Adults With Systemic Lupus Erythematosus December 13, 2022 May 1, 2027
NCT05672576 Recruiting Phase 3 A Research Study to Evaluate the Efficacy and Safety of Cenerimod in Subjects Suffering From Systemic Lupus Erythematosus June 26, 2023 May 1, 2027
NCT05693571 Recruiting N/A Engagement in CHildhood-Onset Systemic Lupus August 2024 November 2026
NCT05763225 Recruiting Validation of Patient E-tool to Measure Systemic Lupus Activity February 9, 2023 September 2024
NCT05845593 Recruiting Relationship Between Data Obtained With the LuGENE® Multiparameter Transcriptomics Blood Test and Clinical and Standard Laboratory Features of Patients With SLE (ReLATE) December 19, 2023 March 5, 2025
NCT05863689 Recruiting Microvascular Ocular Changes of Systemic Lupus Erythematous May 10, 2023 December 2025
NCT05879718 Recruiting Phase 2 A Study to Learn About the Study Medicine (PF-06823859) in Adults With Active CLE or SLE With Skin Symptoms. July 7, 2023 November 18, 2026
NCT05899907 Recruiting Phase 4 Efficacy and Safety of Telitacicept in Early SLE September 1, 2022 September 1, 2025
NCT05961267 Recruiting Study of Gynecological Follow-up of Patients With Autoimmune Disease or Inflammatory Rheumatism July 24, 2023 July 2024
NCT05967520 Recruiting Phase 2 JMKX000189 for Moderate to Severe Active Systemic Lupus Erythematosus September 21, 2023 December 2025
NCT06015230 Recruiting Phase 1/Phase 2 Clinical Study to Investigate the Safety, Tolerability, and Pharmacokinetics of GR1603 in SLE March 8, 2022 October 4, 2028
NCT06166199 Recruiting N/A Effects of High-intensity Interval Training in Patients With Systemic Lupus Erythematosus November 1, 2022 December 31, 2026
NCT06316791 Recruiting Early Phase 1 Exploratory Clinical Study of CNCT19 Anti CD19 Cell Therapy in the Treatment of Refractory Autoimmune Diseases December 14, 2021 December 13, 2025
NCT00381810 Terminated Phase 3 A Study to Evaluate the Safety of Rituximab Retreatment in Subjects With Systemic Lupus Erythematosus June 22, 2006 February 29, 2012
NCT01127321 Terminated Phase 1 A Safety and Tolerability Study of MEDI-570 in Systemic Lupus Erythematosus May 2010 July 2012
NCT02070978 Terminated Phase 2 Long-term Safety and Tolerability of Atacicept (Long-term Follow-Up of Participant Who Participated in ADDRESS II) July 29, 2014 February 9, 2018
NCT00152555 Terminated N/A Physical Therapy for Systemic Lupus Erythematosus (SLE) March 2003 March 2007
NCT00368264 Terminated Phase 2/Phase 3 TNF Blockade With Remicade in Active Lupus Nephritis WHO Class V (TRIAL ) September 2006 June 2009
NCT02428309 Terminated Phase 1 Autologous Polyclonal Tregs for Lupus August 27, 2015 October 3, 2018
NCT05203419 Terminated Phase 1 Multiple Ascending Dose Study of MHS552 in Adults Participants With Systemic Lupus Erythematosus (SLE) March 15, 2022 June 4, 2023
NCT00325741 Terminated Phase 1 Allogeneic Blood Stem Cell Transplantation for Patients With Life-Threatening Systemic Lupus Erythematosus June 2004 October 2015
NCT02711813 Terminated Phase 2 TAB08 in Patients With Systemic Lupus Erythematosus (SLE), Not Adequately Controlled With Current Treatment March 2016 May 2018
NCT03200548 Terminated N/A Acupressure for Fatigue in Systemic Lupus Erythematosus August 14, 2017 July 19, 2019
NCT03407482 Terminated Phase 2 An Extension Study of GDC-0853 in Participants With Moderate to Severe Active Systemic Lupus Erythematosus January 9, 2018 November 20, 2019
NCT02041091 Terminated Phase 3 A Study of Tabalumab (LY2127399) Using Two Different Injection Methods in Participants With Lupus January 2014 November 2015
NCT00113971 Terminated Phase 2 Pharmacokinetics Study of Epratuzumab in Systemic Lupus Erythematosus (SLE) April 2005 June 2007
NCT03488654 Terminated CMR-Lupus Comprehensive Approach by Cardiovascular Magnetic Resonance Tomography July 2010 December 2014
NCT01257802 Terminated Phase 3 GnRH-a for Ovarian Protection During CYC Therapy for Rheumatic Diseases May 2011 November 2015
NCT03517722 Terminated Phase 3 A Study of Ustekinumab in Participants With Active Systemic Lupus Erythematosus April 16, 2018 November 5, 2020
NCT00089804 Terminated Phase 3 Study of LJP 394 in Lupus Patients With History of Renal Disease October 2004 February 2009
NCT04449653 Unknown status Mobile Study to Measure and Predict Lupus Disease Activity Using Digital Signals April 28, 2020 June 1, 2021
NCT01471301 Unknown status Ultrasound Evaluation of Hands in Patients With Systemic Lupus Erythematosus June 2011
NCT00008749 Unknown status Role of Altered CD40-Ligand Gene Transcription in Systemic Lupus Erythematosus
NCT03144063 Unknown status Improving the Assessment of SLE Disease Activity July 11, 2017 June 2018
NCT03142412 Unknown status Lupus Interval Monitoring to Manage Disease Flare and Enable Treatment Optimization April 17, 2017 October 17, 2021
NCT00420121 Unknown status European Society of Cutaneous Lupus Erythematosus (EUSCLE) January 2007 December 2019
NCT03042260 Unknown status Phase 4 Prophylactic Trimethoprim/Sulfamethoxazole to Prevent Severe Infections in Patients With Lupus Erythematous March 1, 2017 August 2021
NCT03746197 Unknown status N/A Interactive Digital Technology to Assess and Improve Cognitive Dysfunction in Patients With Systemic Lupus Erythematosus June 6, 2018 July 1, 2020
NCT02822989 Unknown status N/A Using the Cholinergic Anti-Inflammatory Pathway to Treat Systemic Lupus Musculoskeletal Pain November 1, 2017 November 1, 2020
NCT04032496 Unknown status N/A Contemplation-Based Intervention and Health Outcomes RCT in Lupus Patients January 2020 July 2021
NCT04213690 Unknown status A Pilot Study to Explore the Role of Gut Flora in Lupus March 2, 2020 July 2023
NCT04361734 Unknown status The Role of Lipids in Immune Cell Function in SLE Patients February 15, 2016 August 31, 2020
NCT01852851 Unknown status N/A Employment and Arthritis: Making it Work June 2013 June 2023
NCT03771885 Withdrawn Phase 1 BI 705564 in Patients With Systemic Lupus Erythematosus (SLE) March 16, 2019 January 7, 2020
NCT01702038 Withdrawn Phase 2 Determining the Responses and Impact of Rituximab-instigated Cell Depletion on T Cells in People With SLE September 2009
NCT04060888 Withdrawn Phase 3 A Study of Ustekinumab in Chinese Participants With Active Systemic Lupus Erythematosus July 14, 2020 March 31, 2026
NCT02920424 Withdrawn Phase 1 A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-56022473 in Subjects With Systemic Lupus Erythematosus June 30, 2017 September 26, 2019
MeSH unique ID (MeSH (Medical Subject Headings))
D008180