common variable immunodeficiency
Information
- Disease name
- common variable immunodeficiency
- Disease ID
- DOID:12177
- Description
- "An agammaglobulinemia that is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells and that esults in insufficient production of antibodies needed to respond to exposure of pathogens." [url:http\://en.wikipedia.org/wiki/Common_variable_immunodeficiency, url:http\://www.merck.com/mmpe/sec13/ch164/ch164g.html]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT00004695 | Completed | N/A | Randomized Study of Polyethylene-Glycol-Conjugated Interleukin 2 in Patients With Common Variable Immunodeficiency | September 1997 | March 2000 |
| NCT00220766 | Completed | Phase 3 | Rapid Infusion of Immune Globulin Intravenous (Human) In Primary Immunodeficiency Patients | August 2002 | March 2004 |
| NCT00263237 | Completed | Phase 1 | STA-5326 Meslylate to Treat Gut Inflammation Associated With Common Variable Immunodeficiency | December 2, 2005 | July 23, 2008 |
| NCT00322556 | Completed | Phase 3 | Safety and Efficacy of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID) | November 2005 | April 2008 |
| NCT00520494 | Completed | Phase 4 | Efficacy and Safety of Vivaglobin® in Previously Untreated Patients With Primary Immunodeficiency | March 2007 | October 2008 |
| NCT00542997 | Completed | Phase 3 | Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy | September 2007 | August 2009 |
| NCT00661401 | Completed | N/A | Specific IgG Antibody in Patients With Primary Antibody Deficiencies Treated With Subcutaneous Immunoglobulin | January 2002 | November 2002 |
| NCT01196702 | Completed | Lymphocyte Immunophenotyping in Common Variable Immunodeficiency | September 1, 2020 | December 30, 2023 | |
| NCT01289847 | Completed | Phase 4 | A Study to Find Out How Safe and Effective Gammaplex® is in Young People With Primary Immunodeficiency | March 2011 | April 2014 |
| NCT01884311 | Completed | Phase 3 | Pharmacokinetics (PK) and Safety of Subgam-VF in Primary Immunodeficiency Diseases | August 20, 2015 | May 25, 2017 |
| NCT01963143 | Completed | Phase 3 | Bioequivalence Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Gammaplex® 10 and Gammaplex® 5% in Primary Immunodeficiency Diseases | February 2014 | May 2016 |
| NCT03188419 | Completed | Breadth of Donor Options for People With Inherited Diseases Requiring Allogeneic Hematopoietic Stem Cell Transplant in the Era of Alternative Donor Transplants Using Post-Transplantation Cyclophosphamide | June 14, 2017 | February 20, 2020 | |
| NCT03211689 | Completed | N/A | The Impact of Exercise on Stress, Fatigue, and Quality of Life in Individuals With Primary Immunodeficiency Disease | June 27, 2017 | December 31, 2017 |
| NCT03513328 | Completed | Phase 1/Phase 2 | Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation | June 15, 2018 | February 19, 2023 |
| NCT03534479 | Completed | N/A | Human IgGs and Endothelial Function in Vivo in Humans | April 2010 | April 2013 |
| NCT00015431 | Completed | Immune System and Gut Abnormalities in Patients With Common Variable Immunodeficiency With and Without Gastrointestinal Symptoms | April 16, 2001 | July 10, 2013 | |
| NCT00168012 | Completed | Phase 3 | Efficacy and Safety of Intravenous Immunoglobulin IVIG-F10 in Patients With Primary Immunodeficiencies (PID) | September 2004 | September 2005 |
| NCT00168025 | Completed | Phase 3 | Efficacy and Safety of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID) | September 2004 | March 2006 |
| NCT05593588 | Enrolling by invitation | Phase 2 | Senolytics Treatment of Interstitial Lung Disease in Common Variable Immunodeficiency | April 12, 2023 | December 2026 |
| NCT05481554 | Not yet recruiting | Composition and Function of Gut Microbiota in Porto-sinusoidal Vascular Disease Associated With Variable Common Immunodeficiency | July 2022 | December 2023 | |
| NCT05193552 | Recruiting | Phase 4 | Usage of Spirometry in Managing IgG Therapy in CVID With Airway Disease | January 15, 2024 | December 2026 |
| NCT05321407 | Recruiting | COVID-19 Vaccine Responses in PIDD Subjects | September 24, 2021 | December 31, 2024 | |
| NCT02579967 | Recruiting | Phase 2 | Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies | November 19, 2015 | December 21, 2028 |
| NCT06145100 | Recruiting | Prediction of Portal Hypertension in Patients With CVID (CVID-pHT) | November 1, 2023 | December 31, 2025 | |
| NCT06355323 | Recruiting | N/A | Bronchiectasis Prevalence in Patients With Primary Humoral Immunodefiency in Champagne-Ardenne Region, France | November 28, 2022 | November 28, 2025 |
| NCT03663933 | Recruiting | Phase 2 | Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or Dysregulation | September 4, 2018 | January 1, 2031 |
| NCT00943514 | Recruiting | Natural History of Bronchiectasis | August 1, 2009 | ||
| NCT04925375 | Recruiting | Phase 2 | Abatacept for the Treatment of Common Variable Immunodeficiency With Interstitial Lung Disease | July 14, 2021 | July 2025 |
| NCT04339777 | Recruiting | Phase 2 | Allogeneic Hematopoietic Stem Cell Transplant for Patients With Inborn Errors of Immunity | September 22, 2020 | November 30, 2027 |
| NCT01652092 | Recruiting | N/A | Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies | September 4, 2012 | December 2026 |
| NCT01489618 | Terminated | Phase 2 | "Prime Boost" Vaccination Strategy Combining Conjugated Anti- Pneumococcal Vaccine (s0) and Polysaccharide Anti- Pneumococcal Vaccine (s4) Compared to Polysaccharide Anti- Pneumococcal Vaccine Alone (s4) In Patients With Common Variable Immunodeficiency | June 2009 | March 2013 |
| NCT00006054 | Terminated | N/A | Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies | March 2000 | December 2002 |
- Disase is a (Disease Ontology)
- DOID:2583
- Cross Reference ID (Disease Ontology)
- GARD:6140
- Cross Reference ID (Disease Ontology)
- ICD10CM:D83
- Cross Reference ID (Disease Ontology)
- ICD9CM:279.06
- Cross Reference ID (Disease Ontology)
- MESH:D017074
- Cross Reference ID (Disease Ontology)
- MIM:PS607594
- Cross Reference ID (Disease Ontology)
- ORDO:1572
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:191010004
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0009447
- Exact Synonym (Disease Ontology)
- acquired agammaglobulinemia
- Exact Synonym (Disease Ontology)
- acquired hypogammaglobulinemia
- Exact Synonym (Disease Ontology)
- common variable agammaglobulinemia
- Exact Synonym (Disease Ontology)
- CVID
- Exact Synonym (Disease Ontology)
- sporadic hypogammaglobulinemia
- OrphaNumber from OrphaNet (Orphanet)
- 1572
- ICD10 preferred id (Insert disease from ICD10)
- D0003327
- ICD10 class code (Insert disease from ICD10)
- D83
- MeSH unique ID (MeSH (Medical Subject Headings))
- D017074