Nonalcoholic Steatohepatitis

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Information
Disease name
Nonalcoholic Steatohepatitis
Disease ID
Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT06342947 Active, not recruiting Phase 2 ALG-055009 in Non-cirrhotic Adults With MASH (HERALD) April 1, 2024 December 23, 2024
NCT05084404 Active, not recruiting Phase 2 Efficacy and Safety of Guanabenz for Nonalcoholic Fatty Liver Disease October 29, 2021 June 30, 2023
NCT05809934 Active, not recruiting Phase 2 A Study to Evaluate AZD2693 in Participants Who Are Carriers of the PNPLA3 148M Risk Allele With Non-cirrhotic Non-alcoholic Steatohepatitis With Fibrosis March 15, 2023 October 7, 2025
NCT04971785 Active, not recruiting Phase 2 Study of Semaglutide, and Cilofexor/Firsocostat, Alone and in Combination, in Adults With Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH) August 9, 2021 December 2024
NCT04595474 Active, not recruiting Prevalence of NAFLD and Advanced Fibrosis in Patients With Type 1 Diabetes January 14, 2021 December 30, 2024
NCT00586313 Completed N/A Endoscopic Ultrasound(EUS)-Guided TRUCUT Biopsy (EUS-TCB) of Suspected Nonalcoholic Fatty Liver Disease(NAFLD.) January 2007 July 2008
NCT00586885 Completed N/A Effects of Alanine in Patients With Nonalcoholic Steatohepatitis February 2004 June 2006
NCT00586911 Completed Phase 2 Betaine in Patients With Nonalcoholic Steatohepatitis January 2003 June 2006
NCT00590161 Completed Phase 2 Pentoxifylline in Patients With Nonalcoholic Steatohepatitis December 2006 December 2010
NCT00740610 Completed Phase 2 Safety, Tolerability, Pharmacokinetics and Activity of GS-9450 in Adults With Non-Alcoholic Steatohepatitis (NASH) August 2008 September 2009
NCT00794716 Completed Phase 2 Pharmacokinetics of NRL972 in Patients With Nonalcoholic Steatohepatitis (NASH) and Non-Alcoholic Fatty Liver Disease (NAFLD) June 2008 November 2011
NCT00820651 Completed Phase 3 Efficacy and Safety of Diamel in Patients With Nonalcoholic Steatohepatitis November 2009 April 2012
NCT00856869 Completed Phase 1/Phase 2 Clearance of NRL972 in Patients With Cirrhosis, Nonalcoholic Steatohepatitis (NASH) and in Healthy Volunteers August 2004 April 2005
NCT00994682 Completed Phase 4 University of Texas H.S.C. San Antonio Pioglitazone in Non-Alcoholic Steatohepatitis Trial (UTHSCSA NASH Trial) December 2008 December 2014
NCT01002547 Completed Phase 4 Prevalence of Non-alcoholic Fatty Liver Disease (NAFLD) in Hispanics With Diabetes Mellitus Type 2 (T2DM) and Role of Treatment June 24, 2010 December 31, 2016
NCT01016418 Completed Phase 1/Phase 2 Bovine Colostrum for Patients With Non Alcoholic Fatty Liver Disease January 2010 August 2010
NCT01051219 Completed Phase 3 Anti-Fibrotic Effects of Losartan In Nash Evaluation Study May 2011 December 2014
NCT01066364 Completed Phase 2 Colesevelam Versus Placebo in the Treatment of Nonalcoholic Steatohepatitis February 2010 February 2012
NCT01094158 Completed Phase 2 Study of Aramchol in Patients With Fatty Liver Disease or Nonalcoholic Steatohepatitis November 2010 January 2012
NCT01205087 Completed Phase 2 Safety and Efficacy of Oral Administration of Anti-CD3 Monoclonal Antibody (mAb)in Patients With the Metabolic Syndrome September 2010 April 2011
NCT01237119 Completed Phase 2 Liraglutide Efficacy and Action in Non-Alcoholic Steatohepatitis August 2010 July 2014
NCT00013598 Completed Phase 2 Treatment of Nonalcoholic Steatohepatitis With Pioglitazone March 2001 March 2004
NCT00227110 Completed Phase 4 Role of Pioglitazone in the Treatment of Non-alcoholic Steatohepatitis (NASH) October 2002 January 2006
NCT00267670 Completed Phase 2/Phase 3 Pentoxifylline/Nonalcoholic Steatohepatitis (NASH) Study: The Effect of Pentoxifylline on NASH March 2005 September 2009
NCT00509418 Completed Phase 3 Efficacy and Safety of Viusid in Patients With Nonalcoholic Steatohepatitis February 2007 September 2007
NCT00583999 Completed The Role of Leptin Receptors in NASH January 2006 June 2009
NCT01399645 Completed Phase 2 Study of Liraglutide Versus Insulin on Liver Fat Fraction in Patients With Type 2 Diabetes May 2011 June 2014
NCT01679197 Completed Phase 2 Clinical Protocol to Investigate the Efficacy of Recombinant Human Leptin (Metreleptin) in Nonalcoholic Steatohepatitis (NASH) or Nonalcoholic Fatty Liver Disease (NAFLD) Associated With Lipodystrophy October 8, 2012 July 13, 2016
NCT01828528 Completed Impact of Bariatric Surgery on Nonalcoholic Fatty Liver Disease April 2013 August 2016
NCT01919294 Completed Phase 2 Testosterone Replacement in Non-alcoholic Steatohepatitis (TEREPINS) July 2013 January 30, 2017
NCT02077374 Completed Phase 2 A Study of IDN-6556 in Subjects With NAFLD and Raised Transaminases March 2014 March 2015
NCT02083367 Completed Default Mode Network fMRI Maps as a Predictive Index of Hepatic Encephalopathy Outcome January 2013 February 2015
NCT02148471 Completed Fatty Acids, Genes and Microbiota in Fatty Liver October 2003 August 2015
NCT02210715 Completed Phase 4 Raltegravir-based Antiretroviral Versus Maintaining Any Other Antiretroviral Therapy in HIV Mono-infected Patients March 2015 January 30, 2023
NCT02217475 Completed Phase 2 Efficacy and Safety Study of Cenicriviroc for the Treatment of Nonalcoholic Steatohepatitis (NASH) in Adult Participants With Liver Fibrosis September 18, 2014 June 22, 2017
NCT02412540 Completed N/A Controlled Trial of WLS vs. CLI for Severely Obese Adolescents With NASH April 23, 2015 March 2, 2021
NCT02421094 Completed Phase 2 Clinical Trial to Evaluate Efficacy of GR-MD-02 for Treatment of Liver Fibrosis in Patients With NASH With Advanced Fibrosis September 2015 September 27, 2016
NCT02442687 Completed Phase 2 JKB-121 for the Treatment of Nonalcoholic Steatohepatitis August 1, 2015 September 24, 2017
NCT02510599 Completed Phase 2 Safety and Efficacy of Solithromycin in the Treatment of Nonalcoholic Steatohepatitis Without Cirrhosis December 2015 February 28, 2017
NCT02633956 Completed Phase 2 Combination Obeticholic Acid (OCA) and Statins for Monitoring of Lipids (CONTROL) December 4, 2015 March 12, 2018
NCT02654977 Completed Phase 2 CLINICAL PROTOCOL to Investigate the Long-term Safety and Efficacy of Metreleptin in Various Forms of Partial Lipodystrophy September 29, 2015 November 14, 2019
NCT03061721 Completed Phase 2 Saroglitazar Magnesium in Patients With Nonalcoholic Fatty Liver Disease and/or Nonalcoholic Steatohepatitis April 6, 2017 December 15, 2020
NCT03068078 Completed N/A A Reduced-carbohydrate Diet High in Monounsaturated Fats in Type 2 Diabetes November 2016 June 4, 2021
NCT03151798 Completed N/A The Liver Health Study for Patients With NAFLD August 9, 2017 April 29, 2023
NCT03248882 Completed Phase 2 Phase 2a, Dose-ranging Study With PF-05221304 in Nonalcoholic Fatty Liver Disease (NAFLD) August 22, 2017 March 27, 2019
NCT03332940 Completed Phase 1 An Evaluation of the Safety of Intravenous Tc 99m Tilmanocept and a Comparison of Imaging With Sulfur Colloid in Subjects With and Without NASH December 6, 2017 March 10, 2019
NCT03375008 Completed N/A Predictable MR Index for Nonalcoholic Steatohepatitis (NASH) September 8, 2016 August 7, 2018
NCT03439254 Completed Phase 3 Study Evaluating the Efficacy and Safety of Obeticholic Acid in Subjects With Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis August 30, 2017 September 8, 2022
NCT03445208 Completed Phase 1 A Study of Experimental Medication BMS-986036 Given to Healthy Participants February 14, 2018 May 2, 2018
NCT03449446 Completed Phase 2 Study to Evaluate the Safety and Efficacy of Selonsertib, Firsocostat, Cilofexor, and Combinations in Participants With Bridging Fibrosis or Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH) March 21, 2018 November 19, 2019
NCT03486899 Completed Phase 2 A Study of Experimental Medication BMS-986036 in Adults With Nonalcoholic Steatohepatitis (NASH) and Stage 3 Liver Fibrosis June 19, 2018 August 17, 2021
NCT03486912 Completed Phase 2 A Study of Experimental Medication BMS-986036 in Adults With Nonalcoholic Steatohepatitis (NASH) and Liver Cirrhosis June 12, 2018 September 14, 2021
NCT03656744 Completed Phase 2 A Study of HTD1801 in Adults With Nonalcoholic Steatohepatitis (NASH) and Type 2 Diabetes Mellitus (T2DM) November 26, 2018 March 9, 2020
NCT03674476 Completed Phase 1 An Investigational Study to Evaluate Experimental Medication BMS-986036 in Participants With Different Levels of Kidney Function September 11, 2018 June 24, 2019
NCT03683589 Completed De Novo Lipogenesis in Severity of NAFLD February 1, 2019 July 31, 2020
NCT03723252 Completed Phase 3 Dapagliflozin Efficacy and Action in NASH March 20, 2019 March 28, 2024
NCT03861819 Completed N/A Feasibility of VIIT in Adults With NASH January 1, 2018 December 7, 2018
NCT03987074 Completed Phase 2 Safety, Tolerability, and Efficacy of Monotherapy and Combination Regimens in Participants With Nonalcoholic Steatohepatitis (NASH) July 29, 2019 July 13, 2020
NCT04031729 Completed Phase 1/Phase 2 Aspirin for the Treatment of Nonalcoholic Fatty Liver Disease September 12, 2019 February 23, 2023
NCT04137055 Completed Phase 1 Study in Chinese Healthy Adults to Evaluate the Safety, Tolerability and Pharmacokinetics on ZSP0678, and the Effect of Food on ZSP0678 Pharmacokinetics November 19, 2019 December 9, 2020
NCT04152473 Completed Phase 1 Safety and Tolerability of Oral Proglumide for NASH December 13, 2019 September 9, 2022
NCT04166773 Completed Phase 2 A Study of Tirzepatide (LY3298176) in Participants With Nonalcoholic Steatohepatitis (NASH) November 19, 2019 January 10, 2024
NCT04210245 Completed Phase 2 Study of Aldafermin (NGM282) in Subjects With Compensated Cirrhosis (ALPINE 4) March 23, 2020 February 23, 2023
NCT04235205 Completed Phase 2 Efficacy and Safety of Elobixibat in Combination With Cholestyramine for Nonalcoholic Fatty Liver Disease January 29, 2020 September 30, 2021
NCT04342793 Completed Phase 2 A Study to Evaluate the Efficacy and Safety of ALS-L1023 in Subjects With NASH December 4, 2019 May 11, 2021
NCT04389775 Completed Phase 1 To Evaluate the Safety, Tolerability, PK, and PD of XW003 Injection in Healthy Adult Participants March 29, 2020 September 29, 2021
NCT04399538 Completed Phase 2 Study of Pharmacodynamics and Safety of DGAT2i and ACCi Coadministered in Participants With Sponsor-defined Presumed Non Alcoholic Steatohepatitis August 10, 2020 April 28, 2022
NCT04462081 Completed Non Alcoholic Fatty Liver Disease and Coronary Heart Disease in Type 2 Diabetes Patients January 2013 January 2015
NCT04828551 Completed N/A Noninvasive Biomarkers of Metabolic Liver Disease 1.1 March 18, 2021 November 20, 2021
NCT04887038 Completed Phase 1 First-in-Human Study of SRT-015 in Healthy Subjects. May 3, 2021 February 28, 2022
NCT04944992 Completed Phase 2 A Study of Efinopegdutide (MK-6024) in Participants With Nonalcoholic Fatty Liver Disease (NAFLD) (MK-6024-001) August 4, 2021 October 19, 2022
NCT05309642 Completed N/A Nonalcoholic Fatty Liver Disease - Intermittent Calorie Restriction (FLICR) Study March 7, 2022 December 6, 2023
NCT05343780 Completed Phase 2 Clinical Trial to Investigate the Anti-oxidant Activity of Heptex in Patients With Apparent Risk Factors of NASH May 8, 2019 February 21, 2022
NCT05560607 Completed Phase 1 Knockdown of HSD17B13 mRNA, Pharmacokinetics, Safety, and Tolerability, of AZD7503 in Non-Alcoholic Fatty Liver Disease August 12, 2022 February 27, 2024
NCT05792423 Completed N/A Conditionally Increased Output (CIO) Enhanced Ultrasound System June 30, 2023 May 31, 2024
NCT05824156 Completed Phase 2 CM-101 in NASH Patients - The SPLASH Study February 24, 2021 August 25, 2022
NCT05983328 Completed Phase 1 Phase I Pharmacokinetic Study of HUYPS-1 in Healthy Volunteers May 10, 2016 February 9, 2018
NCT03282305 Not yet recruiting Great China Fatter Liver Consortium (GC_FLC) Study to Assess the Progress of NAFLD/NASH in Chinese April 2018 December 2029
NCT05731596 Not yet recruiting Phase 3 Comparative Clinical Study to Evaluate the Efficacy and Safety of Rosuvastatin Vs CoQ10 on Nonalcoholic Steatohepatitis June 2023 April 2024
NCT03970031 Not yet recruiting Phase 3 A Study of MSDC-0602K to Assess Glycemic Control and Cardiovascular Outcomes in Patients With Pre-T2D or T2D and NAFLD/NASH June 2022 September 2024
NCT02933554 Not yet recruiting N/A Bariatric Embolization of Arteries for the Treatment of Nonalcoholic Steatohepatitis June 2024 June 2027
NCT06465186 Not yet recruiting Phase 2 A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017) July 18, 2024 May 15, 2026
NCT05526144 Recruiting Phase 2 Thyroid Hormone for Treatment of Nonalcoholic Steatohepatitis in Veterans April 1, 2023 March 31, 2029
NCT05211284 Recruiting Phase 2 Saroglitazar Magnesium 4 mg for NASH in People Living With HIV in the US September 26, 2022 March 1, 2025
NCT05877547 Recruiting Phase 2 A Clinical Study of Efinopegdutide in Participants With Precirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-6024-013) June 23, 2023 December 5, 2025
NCT05330923 Recruiting Effect of NNRTI or INSTI on Nonalcoholic Steatosis in HIV/AIDS Patients May 1, 2022 January 1, 2027
NCT05979779 Recruiting Phase 2 Ph 2 Study of the Safety and Efficacy of Three HU6 Dose Levels and Placebo in Nonalcoholic Steatohepatitis September 5, 2023 April 2025
NCT05430178 Recruiting N/A Metabolic Pathology of Pediatric NAFLD May 25, 2022 June 2026
NCT05655221 Recruiting Phase 1 A Trial to Evaluate the Safety Tolerability and Pharmacokinetics of B1344 by Subcutaneous Injection in Healthy Subjects August 30, 2022 January 30, 2024
NCT05680233 Recruiting Phase 1 Safety Study of OA-235i in Subjects With Nonalcoholic Steatohepatitis January 23, 2023 April 2024
NCT04389593 Recruiting Comparative and Additive Diagnostic Performance of Magnetic Resonance Elastography (MRE) and Corrected-T1 (cT1) for Fibrosis and Inflammation in Nonalcoholic Steatohepatitis (NASH) Using Histology as Reference May 21, 2019 August 31, 2024
NCT05720663 Recruiting Predicting Outcomes in Nonalcoholic Steatohepatitis With Advanced Fibrosis April 19, 2023 December 2027
NCT05733897 Recruiting Using Hydroxychloroquine to Treat Nonalcoholic Steatohepatitis June 10, 2022 July 1, 2025
NCT04501406 Recruiting Phase 2 Low-Dose Pioglitazone in Patients With NASH (AIM 2) December 15, 2020 August 31, 2027
NCT04550481 Recruiting Phase 2 Role of Lisinopril in Preventing the Progression of Non-Alcoholic Fatty Liver Disease, RELIEF-NAFLD Study May 11, 2021 October 30, 2024
NCT02815891 Recruiting A Longitudinal Observational Study of Patients With Nonalcoholic Steatohepatitis (NASH) and Related Conditions Across the Entire Spectrum of Nonalcoholic Fatty Liver Disease (NAFLD) July 2016 July 2036
NCT04801849 Recruiting Phase 2 Vitamin E Dosing Study August 5, 2022 August 30, 2025
NCT06365580 Recruiting Phase 1 Dose Escalation Study of Kylo-0603 in Healthy Subjects May 23, 2023 June 30, 2024
NCT05011305 Recruiting Phase 2 Saroglitazar Magnesium for the Treatment of Nonalcoholic Steatohepatitis With Fibrosis August 18, 2021 July 2025
NCT05029583 Recruiting N/A Clinical Outcomes From Enhanced SCREENing Strategies for NASH in Type 2 Diabetes (SCREEN NASH T2D) August 11, 2021 October 5, 2025
NCT05083390 Recruiting Phase 2 Norursodeoxycholic Acid vs. Placebo in NASH July 8, 2019 April 2025
NCT05165706 Recruiting N/A Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance January 31, 2019 December 30, 2024
NCT01355575 Terminated Phase 4 Rifaximin in Fatty Liver Disease May 2011 September 2012
NCT03329885 Terminated Phase 1/Phase 2 A Study of Experimental Medication BMS-986251, Taken by Mouth, in Healthy Participants and Patients With Average to Very Serious Psoriasis November 2, 2017 June 26, 2018
NCT03028740 Terminated Phase 3 AURORA: A Study for the Efficacy and Safety of Cenicriviroc (CVC) for the Treatment of Liver Fibrosis in Adults With Nonalcoholic Steatohepatitis (NASH) April 5, 2017 March 9, 2021
NCT03676231 Terminated Phase 2 Study of SGM-1019 in Patients With Nonalcoholic Steatohepatitis (NASH) January 18, 2019 May 1, 2019
NCT03053050 Terminated Phase 3 Safety and Efficacy of Selonsertib in Adults With Nonalcoholic Steatohepatitis (NASH) and Bridging (F3) Fibrosis February 13, 2017 June 19, 2019
NCT03053063 Terminated Phase 3 Safety and Efficacy of Selonsertib in Adults With Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH) January 30, 2017 May 6, 2019
NCT03059446 Terminated Phase 2 Rollover Study of Cenicriviroc for the Treatment of Liver Fibrosis in Participants With Nonalcoholic Steatohepatitis February 14, 2017 January 5, 2021
NCT04565717 Terminated Phase 1 A Study of ALN-HSD in Healthy Adult Subjects and Adult Patients With Nonalcoholic Steatohepatitis (NASH) October 9, 2020 December 21, 2023
NCT04583423 Terminated Phase 2 A Study of MK-3655 in Individuals With Pre-cirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-3655-001) November 11, 2020 April 13, 2023
NCT01260246 Terminated N/A Sitagliptin for the Treatment of Non-alcoholic Steatohepatitis in Patients With Type 2 Diabetes December 2010 April 2015
NCT00878592 Terminated N/A Effect of Dietary and Life Style Modification on Post Liver Transplant Obesity October 2008
NCT04147195 Terminated Phase 2 Study of Various Treatments in Non-alcoholic Fatty Liver Disease (NAFLD) Patients Who Have Aspects of Non-alcoholic Steatohepatitis (NASH) June 4, 2020 January 6, 2022
NCT02792634 Unknown status Pathogenesis of Non-alcoholic Steatohepatitis and Liver Regeneration After Bariatric Surgery June 2016 December 2022
NCT04012242 Unknown status Innovative Liver Elasticity, Attenuation, and Dispersion Ultrasound Study June 15, 2019 July 31, 2022
NCT04710524 Unknown status Phase 2 FM101 Efficacy Study in Adults With Nonalcoholic Fatty Liver Disease or Nonalcoholic Steatohepatitis June 10, 2021 August 31, 2023
NCT03725631 Unknown status N/A Non-invasive Evaluation of Liver Fibrosis, Steatosis, and NASH in NAFLD September 1, 2016 August 31, 2019
NCT00152711 Unknown status N/A Impact of nCPAP Treatment on Liver Function in Patients With Sleep Apnea Syndrome and Nonalcoholic Steatohepatitis September 2004
NCT00699036 Unknown status Phase 2 Rosiglitazone Versus Rosiglitazone and Metformin Versus Rosiglitazone and Avandia in the Treatment of Nonalcoholic Steatohepatitis (NASH) April 2007 August 2009
NCT02307344 Unknown status N/A Effect of Nigella Sativa on Nonalcoholic Steatohepatitis and Steatosis January 2015 January 2017
NCT05012423 Unknown status Phase 1 FTIH Study of ECC0509 in Healthy Volunteers July 7, 2021 February 20, 2022
NCT03602573 Unknown status Liver Fibrosis in Peri-menopausal Women August 1, 2018 July 31, 2019
NCT02717000 Unknown status NASH: Non-invasive Diagnostic Markers and Imaging April 2016 December 2017
NCT02764047 Unknown status N/A Probiotics in the Treatment of NAFLD January 2015 January 2018
NCT00842205 Unknown status N/A Role of Heme Oxygenase in the Pathogenesis of Hepatocellular Injury in Chronic Hepatitis C Virus (HCV) Infection January 2007 December 2009
NCT02574325 Unknown status Phase 2 A Study to Assess ARI-3037MO on Hepatic Fat Metabolism in Patients With Dysglycemia and Evidence of Hepatic Steatosis October 2015 December 2016
NCT04216693 Withdrawn Phase 2 Digoxin for Patients With Non-alcoholic Steatohepatitis (NASH) June 1, 2020 June 1, 2023
NCT03163810 Withdrawn N/A A Study to See if Low Level Laser Light Therapy (LLLT) Can Improve the Condition of Nonalcoholic Steatohepatitis (NASH) February 6, 2017 December 13, 2017
NCT01466894 Withdrawn Phase 2 Safety and Efficacy Study of IMM 124-E (Bovine Colostrum) for Patients With Nonalcoholic Steatohepatitis December 2012 December 2013
NCT02769091 Withdrawn Phase 2 A Study in Adult Patients With Nonalcoholic Steatohepatitis Who Also Have Type 2 Diabetes September 30, 2016 February 28, 2018