retinoblastoma (Cancer)
Information
- Disease name
- retinoblastoma
- Disease ID
- DOID:768
- Description
- "A retinal cell cancer and malignant neoplasm of retina and neuroblastoma and neuroendocrine tumors that derives_from the tissues of the retina." [url:http\://www.cancer.gov/cancertopics/types/retinoblastoma]
Disease area statistics
Chromosome band
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT04156347 | Active, not recruiting | Phase 1 | Topotecan Episcleral Plaque for Treatment of Retinoblastoma | June 16, 2021 | October 14, 2024 |
| NCT04483778 | Active, not recruiting | Phase 1 | B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults | July 13, 2020 | December 2040 |
| NCT04342572 | Active, not recruiting | Phase 1 | Intra-arterial Chemotherapy for Retinoblastoma | August 11, 2020 | January 4, 2025 |
| NCT01906814 | Active, not recruiting | Phase 3 | Adjuvant Chemotherapy for High-risk Retinoblastoma After Enucleation | August 2013 | April 2024 |
| NCT00110110 | Active, not recruiting | Phase 2 | Combination Chemotherapy and Cyclosporine Followed by Focal Therapy for Bilateral Retinoblastoma | June 2004 | December 31, 2024 |
| NCT00186888 | Active, not recruiting | Phase 3 | Study of Treatment for Patients With Cancer of the Eye -Retinoblastoma | April 7, 2005 | January 2025 |
| NCT01783535 | Active, not recruiting | Phase 2 | Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma | June 19, 2013 | January 2028 |
| NCT02866136 | Active, not recruiting | Phase 2 | Conservative Treatments of Retinoblastoma | February 2012 | September 2035 |
| NCT00006102 | Completed | Phase 2 | Rebeccamycin Analogue in Treating Children With Solid Tumors or Non-Hodgkin's Lymphoma | July 2000 | |
| NCT00006246 | Completed | Phase 1 | Busulfan in Treating Children and Adolescents With Refractory CNS Cancer | November 2000 | |
| NCT00024258 | Completed | Phase 2 | Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors | March 2001 | May 2009 |
| NCT00053118 | Completed | Phase 1 | Chemotherapy and Stem Cell Transplantation in Treating Children With Central Nervous System Cancer | March 2002 | July 2004 |
| NCT00179920 | Completed | Phase 2 | Chemotherapy Treatment for Children With Intraocular Germ-Line Retinoblastoma | April 1996 | September 2006 |
| NCT00336531 | Completed | Phase 4 | Efficacy of Prophylactic Itraconazole in High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation | April 2006 | October 2008 |
| NCT00342797 | Completed | Retinoblastoma Biomarker Study | November 17, 1993 | March 6, 2024 | |
| NCT04429139 | Completed | N/A | Photodynamic Therapy With Visudyne for Human Retinoblastoma: A Preliminary Study | February 1, 2011 | May 30, 2020 |
| NCT00445965 | Completed | Phase 2 | Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer | January 2006 | February 1, 2023 |
| NCT00460876 | Completed | Phase 1 | Phase I Trial of Periocular Topotecan in Retinoblastoma | March 2007 | April 2008 |
| NCT00582049 | Completed | Research on the Environment and Children's Health: Retinoblastoma | August 2003 | June 2008 | |
| NCT04164134 | Completed | New Strategies to Detect Cancers in Carriers of Mutations in RB1 | December 13, 2018 | March 31, 2023 | |
| NCT00718783 | Completed | Molecular Analysis of Retinoblastoma | April 2007 | December 2016 | |
| NCT00857519 | Completed | N/A | A Study of the Effectiveness of a Local Injection of Chemotherapy for Retinoblastoma | January 2009 | April 2014 |
| NCT00901238 | Completed | Phase 1/Phase 2 | Intra-arterial Chemotherapy(Chemosurgery) for Retinoblastoma | May 2006 | July 2009 |
| NCT03935074 | Completed | Superselective Intra-arterial Chemotherapy Treatment for Retinoblastoma- 5 Year Results From Turkey | August 30, 2016 | November 30, 2016 | |
| NCT03764930 | Completed | Attention to Retinoblastoma Diagnosed in the Trauma Setting | January 1, 2013 | November 30, 2018 | |
| NCT01048892 | Completed | Phase 1 | Seneca Valley Virus-001 and Cyclophosphamide in Treating Young Patients With Relapsed or Refractory Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine Features | September 2009 | |
| NCT03677128 | Completed | N/A | Mobile Health Case Management System for Reducing Pediatric Treatment Abandonment | July 23, 2019 | April 22, 2022 |
| NCT01331135 | Completed | Phase 1 | Aflac ST0901 CHOANOME - Sirolimus in Solid Tumors | April 2011 | August 9, 2017 |
| NCT02792036 | Completed | Phase 1 | Intravitreal Carboplatin for the Treatment of Participants With Recurrent or Refractory Intraocular Retinoblastoma | November 1, 2016 | October 4, 2019 |
| NCT02764398 | Completed | Cardio-respiratory Events During Ophthalmic Artery Chemotherapy for Retinoblastoma Under a Deep Anesthesia | December 2013 | ||
| NCT01505569 | Completed | N/A | Auto Transplant for High Risk or Relapsed Solid or CNS Tumors | October 20, 2011 | February 1, 2024 |
| NCT02390843 | Completed | Phase 1 | Simvastatin With Topotecan and Cyclophosphamide in Relapsed and/or Refractory Pediatric Solid and CNS Tumors | February 2015 | September 22, 2019 |
| NCT01598454 | Completed | Phase 1 | Use of Racotumomab in Patients With Pediatric Tumors Expressing N-glycolylated Gangliosides | February 2011 | June 2015 |
| NCT02319486 | Completed | Phase 4 | CEV With/Without Periocular Carboplatin Chemotherapy for Extraocular Retinoblastoma | January 2009 | April 2014 |
| NCT01661400 | Completed | Phase 1 | Anti-Angiogenic Therapy Post Transplant (ASCR) for Pediatric Solid Tumors | October 26, 2012 | December 27, 2023 |
| NCT01884194 | Completed | Morphological Analysis of the Pineal Gland in Pediatric Retinoblastoma Patients Using Magnetic Resonance Imaging | November 2013 | February 2015 | |
| NCT00002675 | Completed | Phase 2 | Chemotherapy in Treating Patients With Retinoblastoma | May 1995 | January 2001 |
| NCT00002794 | Completed | Phase 2 | Carboplatin Plus Vincristine in Treating Children With Retinoblastoma | February 1996 | June 2001 |
| NCT00003022 | Completed | Phase 1 | Monoclonal Antibody Therapy in Treating Patients With Leptomeningeal Cancer | April 1997 | January 2005 |
| NCT00003173 | Completed | Phase 2 | High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors | September 1997 | May 2003 |
| NCT00002515 | Completed | Phase 2 | Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Rare Cancer | October 1992 | April 2005 |
| NCT06367569 | Completed | Evaluation of MRI of the Pineal Gland in Retinoblastoma | October 1, 2012 | September 1, 2023 | |
| NCT00004006 | Completed | Phase 2 | Combination Chemotherapy, Radiation Therapy, and Bone Marrow Transplantation in Treating Patients With Retinoblastoma | November 1997 | September 2005 |
| NCT02193724 | Completed | Feasibility of Generating Pluripotent Stem Cells From Patients With Familial Retinoblastoma | November 4, 2014 | August 23, 2019 | |
| NCT06227962 | Enrolling by invitation | Cognitive Functioning and Health Related Quality of Life in Retinoblastoma Survivors | October 26, 2023 | March 31, 2028 | |
| NCT03655223 | Enrolling by invitation | Early Check: Expanded Screening in Newborns | October 15, 2018 | December 31, 2025 | |
| NCT06424301 | Not yet recruiting | Early Phase 1 | Targeting NUDT21 siRNA Drugs for Patients With Refractory Retinoblastoma | May 21, 2024 | May 21, 2027 |
| NCT04425434 | Recruiting | Therapeutic Recommendations For The Treatment Of Children With A Retinoblastoma | November 1, 2020 | October 2029 | |
| NCT04428879 | Recruiting | Phase 1 | Topotecan Episcleral Plaque for Treatment of Retinoblastoma | June 16, 2020 | October 15, 2030 |
| NCT02870907 | Recruiting | Phase 2 | Adjuvant Treatment in Extensive Unilateral Retinoblastoma Primary Enucleated (RB SFCE 2009) | March 2010 | September 2030 |
| NCT03016156 | Recruiting | N/A | Determination of the Sensitivity and Specificity of a Smartphone Application to Detect Retinoblastoma | March 15, 2018 | July 30, 2026 |
| NCT03050268 | Recruiting | Familial Investigations of Childhood Cancer Predisposition | April 6, 2017 | March 31, 2037 | |
| NCT03267459 | Recruiting | Can Pretreatment MRI be Used to Predict Intra-arterial Chemotherapy Response in Retinoblastoma? | January 11, 2018 | July 2026 | |
| NCT03546387 | Recruiting | Determining Whether Multiple Anesthesia Exposures Affect Cognitive Function for Retinoblastoma Patients | May 7, 2018 | May 7, 2025 | |
| NCT03618381 | Recruiting | Phase 1 | EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults | June 18, 2019 | June 2040 |
| NCT06367530 | Recruiting | Trilateral Retinoblastoma: Incidence and Outcomes | January 1, 2024 | December 31, 2029 | |
| NCT01109394 | Recruiting | Comprehensive Omics Analysis of Pediatric Solid Tumors and Establishment of a Repository for Related Biological Studies | April 21, 2010 | ||
| NCT05080010 | Recruiting | Phase 3 | Adjuvant Chemotherapy for High-risk Postenucleation Retinoblastoma | November 1, 2020 | December 31, 2030 |
| NCT03932786 | Recruiting | Studying Health Outcomes After Treatment in Patients With Retinoblastoma | January 24, 2019 | January 2031 | |
| NCT00898755 | Recruiting | Collecting and Storing Tissue From Young Patients With Cancer | March 5, 2007 | ||
| NCT00639301 | Recruiting | Retinoblastoma Survivor Study: Assessment of General Health and Quality of Life | March 2008 | March 2025 | |
| NCT04564521 | Recruiting | N/A | Nitroglycerin for Intra-arterial Chemotherapy in Pediatric Retinoblastoma. | September 28, 2020 | December 30, 2024 |
| NCT04681417 | Recruiting | Phase 2/Phase 3 | Ocular Conservative Treatment for Retinoblastoma : Efficacy of the New Management Strategies and Visual Outcome | March 25, 2021 | January 20, 2036 |
| NCT04700514 | Recruiting | N/A | Effect of Anesthetic Drugs on Neurocognitive Function in Children With Retinoblastoma Requiring Multiple Anesthetic Exposure - Preliminary Study | February 5, 2021 | February 20, 2025 |
| NCT04799002 | Recruiting | Phase 3 | Topotecan and Melphalan for Retinoblastoma | March 11, 2021 | December 30, 2027 |
| NCT04959097 | Recruiting | RB Liquid Biopsy Biorepository | January 1, 2017 | December 31, 2030 | |
| NCT00432445 | Terminated | Phase 2 | Proton Beam Radiation Therapy for Intraocular and Periocular Retinoblastoma | January 2007 | February 2014 |
| NCT02617862 | Terminated | N/A | PCI Imaging System in Pediatric Ophthalmology | October 2015 | September 2017 |
| NCT00003926 | Terminated | Phase 1 | Amifostine to Protect From Side Effects of PSCT in Treating Patients With Solid Tumors | November 1998 | August 2003 |
| NCT01987596 | Terminated | Phase 3 | Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer | August 2013 | June 2018 |
| NCT01642823 | Terminated | Cancer Biology of Retinoblastoma | July 2012 | December 2015 | |
| NCT00623077 | Terminated | Phase 1 | MT2004-30: Tomotherapy for Solid Tumors | August 2005 | October 2016 |
| NCT01558960 | Terminated | N/A | Intravitreal Injections of Melphalan for Retinoblastoma | March 2012 | August 2015 |
| NCT01857752 | Terminated | Phase 2 | Phase II Study Temozolomide for Retinoblastoma Metastatic to the Central Nervous System for Patients From Guatemala | March 2012 | June 2015 |
| NCT01466855 | Terminated | Early Phase 1 | A Study of Intra-Ophthalmic Artery Topotecan Infusion for the Treatment of Retinoblastoma | October 2011 | October 2015 |
| NCT01393769 | Terminated | Phase 2 | Intra-arterial Chemotherapy With Melphalan for the Treatment of Retinoblastoma (RTB) in Advanced Intraocular Stage | November 2009 | May 2013 |
| NCT01293539 | Terminated | Phase 2 | Intra-arterial Chemotherapy for the Treatment of Intraocular Retinoblastoma | March 2011 | August 2016 |
| NCT02116959 | Terminated | Phase 1 | Alternating Systemic Chemotherapy and Intra-Arterial Melphalan (IAM) Chemotherapy in Children With Intra-Ocular Retinoblastoma | July 23, 2014 | May 25, 2019 |
| NCT05028270 | Unknown status | Treatment of Intraocular Retinoblastoma | June 20, 2022 | August 1, 2023 | |
| NCT02137928 | Unknown status | Phase 3 | Carboplatin Periocular Injection for Retinoblastoma | January 2006 | December 2015 |
| NCT02329002 | Unknown status | SPT Screening in Irradiated Hereditary Retinoblastoma Survivors | October 2014 | October 2023 | |
| NCT02933333 | Unknown status | Phase 4 | G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor | September 27, 2016 | December 2020 |
| NCT03439397 | Unknown status | N/A | RCT of Ballon Technique VS Selective Ophthalmic Artery Infusion For the Retinoblastoma Patients | March 2018 | December 2020 |
| NCT03559894 | Unknown status | Severe and Transient Hypoxemia During Selective Intra-arterial Chemotherapy for Retinoblastoma in Children: Evaluation of the Right-sided Heart Function. | January 1, 2018 | May 31, 2019 | |
| NCT00906113 | Unknown status | Phase 1/Phase 2 | Intra-arterial Chemotherapy for Children With Retinoblastoma | June 2011 | December 2017 |
| NCT04344652 | Unknown status | N/A | Photoscreening for Retinoblastoma | June 1, 2020 | May 31, 2021 |
| NCT04451304 | Unknown status | Autonomic Reflexes During Intra-arterial Chemotherapy for Retinoblastoma | June 15, 2020 | July 15, 2021 | |
| NCT00360750 | Unknown status | N/A | Chemotherapy With or Without Radiation Therapy or Observation in Treating Young Patients With Advanced Retinoblastoma Who Have Undergone Surgery to Remove the Eye | September 2005 | |
| NCT04990271 | Unknown status | Phase 2 | A Clinical Study on the Efficacy and Safety of VEC Intravenous Chemotherapy Combined With Conbercept Intravitreal Injection in the Treatment of Retinoblastoma | July 5, 2021 | July 15, 2023 |
| NCT01899066 | Unknown status | Phase 2 | Efficacy Study of Lucentis in the Treatment of Retinoblastoma | July 2013 | December 2015 |
| NCT05308043 | Unknown status | Deep Learning in Retinoblastoma Detection and Monitoring. | March 1, 2020 | October 1, 2022 | |
| NCT00278031 | Unknown status | Quality of Life in Children Cured of Retinoblastoma | March 2006 | December 2017 | |
| NCT00003273 | Withdrawn | Phase 2 | Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Brain Tumor | November 1997 | |
| NCT01151748 | Withdrawn | Phase 2 | Intra-arterial Chemotherapy for Advanced Intraocular Retinoblastoma | September 2010 | March 2012 |
| NCT00980551 | Withdrawn | N/A | Pilot Study of Topotecan/Vincristine With Subconjunctival Carboplatin for Patients With Bilateral Retinoblastoma | May 2010 | March 2012 |
| NCT02655432 | Withdrawn | Performance of a Photoscreener for Vision Screening in a Haitian Pediatric Population | January 2016 | June 2016 |
- Disase is a (Disease Ontology)
- DOID:771
- Cross Reference ID (Disease Ontology)
- GARD:7563
- Cross Reference ID (Disease Ontology)
- ICDO:9510/3
- Cross Reference ID (Disease Ontology)
- MESH:D012175
- Cross Reference ID (Disease Ontology)
- MIM:180200
- Cross Reference ID (Disease Ontology)
- NCI:C7541
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:154553002
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0035335
- Exact Synonym (Disease Ontology)
- neuroblastoma of Retina
- Exact Synonym (Disease Ontology)
- RB
- Exact Synonym (Disease Ontology)
- RB - Retinoblastoma
- HPO Human Phenotype ID (Human Phenotype Ontology)
- HP:0009919
- OrphaNumber from OrphaNet (Orphanet)
- 790
- MeSH unique ID (MeSH (Medical Subject Headings))
- D012175