mitral valve insufficiency
Information
- Disease name
- mitral valve insufficiency
- Disease ID
- DOID:11502
- Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT03066050 | Active, not recruiting | Long Term Follow Up for CTSN Mitral Valve Repair Studies | May 3, 2017 | May 2024 | |
| NCT02974881 | Active, not recruiting | N/A | HighLife™ Transcatheter Mitral Valve Replacement System Study | July 20, 2017 | December 15, 2023 |
| NCT01757665 | Active, not recruiting | N/A | ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New Tissue Treatment Platform (COMMENCE) | December 11, 2012 | August 2026 |
| NCT04245956 | Active, not recruiting | N/A | Impact of Mitral Regurgitation on Coronary Haemodynamics and Instantaneous Effect of Transcatheter Mitral Valve Repair | January 8, 2020 | January 1, 2025 |
| NCT02322840 | Active, not recruiting | N/A | Transcatheter Mitral Valve Replacement System (TMVR) Pilot Study and The Early Feasibility Study of the TMVR Transseptal System | April 2015 | December 2028 |
| NCT06191718 | Active, not recruiting | N/A | Clinical Investigation for the Foldax Tria Mitral Valve- India | March 1, 2023 | December 1, 2024 |
| NCT03581656 | Active, not recruiting | N/A | ChordArt System for Mitral Regurgitation | March 21, 2018 | December 2023 |
| NCT03193801 | Active, not recruiting | N/A | PARTNER 3 Trial - Mitral Valve in Valve | February 1, 2018 | August 2031 |
| NCT05526560 | Active, not recruiting | Real-world Clinical Outcomes of the MITRIS RESILIA Mitral Valve | January 11, 2023 | December 2035 | |
| NCT01074671 | Completed | Phase 4 | CG Future® Annuloplasty Ring/Band Clinical Trial | June 2009 | September 2011 |
| NCT01112566 | Completed | EASE MITRAL Expertise-based Assessment Study on Clinical Efficacy of Profile 3D in MITRAL Valve Annuloplasty | February 2013 | May 2017 | |
| NCT01137734 | Completed | N/A | CARDINAL Adjustable Annuloplasty Ring System For Treatment of Mitral Regurgitation | March 2010 | January 2014 |
| NCT01172184 | Completed | Left Atrial Distensibility to Predict Left Ventricular Filling Pressure and Prognosis in Patients With Severe Mitral Regurgitation | July 2010 | January 2011 | |
| NCT01334801 | Completed | Biomarkers in Aortic Stenosis - B.A.S.S. | July 2010 | January 31, 2020 | |
| NCT00001314 | Completed | Investigation of Heart Function in Patients With Heart Valve Defects | May 1992 | March 2001 | |
| NCT01931956 | Completed | N/A | Real World Expanded Multicenter Study of the MitraClip® System (REALISM) | January 22, 2009 | June 2018 |
| NCT01940120 | Completed | N/A | EVEREST II Pivotal Study High Risk Registry (HRR) | February 2007 | February 2013 |
| NCT01966146 | Completed | N/A | Examination of Valve Insufficiency Before and After MitraClip or TAVI Procedure by 3D Echocardiography Compared to MRI | May 2013 | October 2014 |
| NCT02180893 | Completed | Phase 4 | The Use of Paravertebral Block for Cardiac Surgery | January 2013 | April 2014 |
| NCT01784055 | Completed | NeoChord TACT Post-Market Surveillance Registry | March 2013 | July 2016 | |
| NCT00082121 | Completed | Phase 2 | Safety and Efficacy of TP10, a Complement Inhibitor, in Adult Women Undergoing Cardiopulmonary Bypass Surgery | April 2004 | December 2005 |
| NCT00209274 | Completed | N/A | Pivotal Study of a Percutaneous Mitral Valve Repair System | August 2005 | December 2014 |
| NCT00209339 | Completed | Phase 1/Phase 2 | Feasibility Study of a Percutaneous Mitral Valve Repair System. | July 2003 | October 2011 |
| NCT00636987 | Completed | N/A | Aortic or Mitral Valve Replacement With the Biocor and Biocor Supra | April 2007 | March 2016 |
| NCT00727012 | Completed | N/A | Multicenter International Trial Ring AnnulopLasty | June 2008 | November 2010 |
| NCT00806988 | Completed | N/A | Comparing the Effectiveness of a Mitral Valve Repair Procedure in Combination With Coronary Artery Bypass Grafting (CABG) Versus CABG Alone in People With Moderate Ischemic Mitral Regurgitation | December 2008 | May 2015 |
| NCT00807040 | Completed | Phase 2 | Comparing the Effectiveness of Repairing Versus Replacing the Heart's Mitral Valve in People With Severe Chronic Ischemic Mitral Regurgitation | December 2008 | March 2014 |
| NCT00903370 | Completed | Phase 2 | Surgical Ablation Versus No Surgical Ablation for Patients With Atrial Fibrillation Undergoing Mitral Valve Surgery | January 2010 | September 2015 |
| NCT02325830 | Completed | N/A | CARILLON Mitral Contour System® for Reducing Functional Mitral Regurgitation | March 2015 | July 2018 |
| NCT02371863 | Completed | Normal Values in Stress Echocardiographic Parameters in Patients After Successful Mitral Valve Repair for Organic MR | December 2014 | December 2015 | |
| NCT02375282 | Completed | N/A | Physical and Functional Recovery From Cardiac Surgery in Hospitalized Patients: A Feasibility Pilot Study | March 2015 | July 2016 |
| NCT02432196 | Completed | N/A | CE Mark Study for the Harpoon Medical Device in Poland | December 11, 2015 | November 16, 2022 |
| NCT02444338 | Completed | N/A | A Clinical Evaluation of the Safety and Effectiveness of the MitraClip System in the Treatment of Clinically Significant Functional Mitral Regurgitation | March 2015 | April 19, 2024 |
| NCT02604745 | Completed | Degenerative Mitral Regurgitation in Intermediate Risk Patients | March 2016 | January 2021 | |
| NCT02607527 | Completed | N/A | Annular Reshaping of the Mitral Valve for Patients With Mitral Regurgitation Using the Millipede IRIS System | May 8, 2017 | December 19, 2019 |
| NCT02687932 | Completed | Phase 4 | Pharmacological Reduction of Functional, Ischemic Mitral REgurgitation | March 2016 | January 2, 2018 |
| NCT02768870 | Completed | N/A | CE Mark Study for the Harpoon Medical Device | April 28, 2016 | September 6, 2022 |
| NCT02771275 | Completed | N/A | Safety and Early Feasibility Study of the Harpoon Medical Device (EFS) | February 15, 2015 | July 16, 2021 |
| NCT03470155 | Completed | Operative Mitral Valve Reconstruction in Functional mv Insufficiency With Reduced Systolic Ventricle Function | June 5, 2018 | July 31, 2023 | |
| NCT04156295 | Completed | Percutaneous Mitral Valve Intervention: Predicting Improvements in Left Ventricular Performance | March 20, 2019 | December 31, 2020 | |
| NCT04231331 | Completed | Phase 3 | Ertugliflozin for Functional Mitral Regurgitation | November 4, 2020 | November 15, 2023 |
| NCT04351984 | Completed | Transcatheter Mitral Valvuloplasty Pilot Study | October 20, 2020 | December 31, 2021 | |
| NCT05695287 | Completed | Phase 1 | The Effects of Sevoflurane, Isoflurane and Propofol During Cardiac Surgery | January 22, 2021 | December 16, 2022 |
| NCT05696509 | Completed | Phase 3 | Influence of Anesthetics on Clinical Outcome in Mitral and Aortic Valve Replacement in Adults | January 3, 2020 | October 16, 2022 |
| NCT05742789 | Completed | Phase 1 | Effect of Anesthetics on Troponin I and С-reactive Protein | November 30, 2021 | January 9, 2023 |
| NCT06408779 | Completed | Study on Surgical Treatment Strategies for Moderate Ischemic Mitral Regurgitation | August 1, 2023 | April 1, 2024 | |
| NCT05508438 | Not yet recruiting | N/A | To Evaluate the Efficacy and Safety of the Transfemoral Mitral Valve Repair System in the Treatment of Patients With Moderately Severe and Severe Functional Mitral Regurgitation(FMR) Who Remained Clinically Symptomatic After Guideline-directed Medical Treatment | August 30, 2022 | December 30, 2027 |
| NCT05927441 | Not yet recruiting | N/A | DragonFly EU Pivotal Study | December 1, 2023 | May 1, 2029 |
| NCT03962023 | Recruiting | Prognostic Impact of Imaging Parameters in Patients With Primary Mitral Insufficiency by Prolapse (COHORTE-IM) | September 4, 2019 | September 2034 | |
| NCT04153292 | Recruiting | N/A | The ENCIRCLE Trial | November 12, 2020 | February 2031 |
| NCT02506387 | Recruiting | Belgian Mitraclip Registry | January 2015 | December 2025 | |
| NCT04822675 | Recruiting | N/A | REvascularization and Valve Intervention for Ischemic Valve diseasE: REVIVE Trial | August 12, 2021 | August 2026 |
| NCT04384198 | Recruiting | N/A | TransCranial Doppler for REDUCtion of Silent strokE During MitraClip Implantation | August 13, 2020 | December 2024 |
| NCT03142152 | Recruiting | N/A | The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR | January 1, 2018 | December 31, 2030 |
| NCT05902897 | Recruiting | Aortic or Mitral Valve Replacement With the Braile Biomédica® Bovine Pericardium Valvular Bioprosthesis | January 1, 2023 | October 30, 2023 | |
| NCT04343313 | Recruiting | N/A | The Half Moon Transcatheter Mitral Valve Repair (TMVr) Pilot Study | December 8, 2020 | December 31, 2029 |
| NCT02803957 | Recruiting | N/A | Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair | November 3, 2016 | July 2027 |
| NCT03433274 | Recruiting | N/A | Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation | June 15, 2018 | June 2028 |
| NCT06235385 | Recruiting | European Association of Cardiovascular Imaging Multiple and Mixed Valvular Disease Study | February 7, 2024 | August 1, 2029 | |
| NCT03470246 | Recruiting | N/A | Personalized Activity Intervention in Rehabilitation After Cardiac Operations (the PACO Trial) | April 6, 2018 | March 1, 2028 |
| NCT04190602 | Recruiting | Multicenter Post-Market Observational Registry of the NeoChord Artificial Chordae Delivery System | February 9, 2020 | December 2027 | |
| NCT05736289 | Recruiting | Evaluation of Mitral Valve Insufficiency Under General Anesthesia | February 13, 2023 | July 1, 2025 | |
| NCT03285724 | Terminated | N/A | Safety and Performance Study of the Harpoon Mitral Valve Repair System | May 16, 2017 | April 20, 2018 |
| NCT01708265 | Terminated | N/A | The Dutch Asymptomatic Mitral Regurgitation Trial | February 2013 | February 2021 |
| NCT03311295 | Terminated | N/A | MitrAl ValvE RepaIr Clinical Trial (MAVERIC Trial) - United States | April 3, 2018 | April 26, 2021 |
| NCT00700947 | Terminated | Phase 1 | Using Beta Blockers to Treat Mitral Regurgitation | October 2007 | September 2009 |
| NCT04098328 | Terminated | Early Feasibility EXperience of Posterior Leaflet RestOration to REduce Mitral Regurgitation | January 1, 2020 | February 2, 2023 | |
| NCT00608140 | Terminated | Phase 3 | Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure | March 2008 | March 2010 |
| NCT02428010 | Terminated | N/A | Twelve Transcatheter Mitral Valve Replacement (TMVR) Pilot Study | September 2014 | April 2021 |
| NCT02534155 | Terminated | Phase 4 | High and Intermediate Risk Degenerative Mitral Regurgitation Treatment: A Trial Comparing MitraClip® to Surgical Therapy | April 2015 | September 2018 |
| NCT02703311 | Terminated | N/A | REPAIR - transcatheteR rEPair of mitrAl Insufficiency With caRdioband System | August 2016 | December 2018 |
| NCT02818166 | Unknown status | N/A | Magnetic Resonance Imaging for Cerebral Embolization During Minimal Invasive Mitral Valve Surgery | June 2014 | January 2017 |
| NCT01201070 | Unknown status | Phase 4 | Study of Administration Of Antithrombin in Patients With Low Plasmatic Levels of Antithrombin After Cardiac Surgery | September 2009 | November 2011 |
| NCT03145376 | Unknown status | Clinical and Geriatric Assessment in Elderly Patients Before and After TAVI or MitraClip Positioning | June 1, 2017 | October 30, 2020 | |
| NCT01368575 | Unknown status | Phase 4 | Surgical Treatment of Ischemic Mitral Regurgitation | May 2011 | November 2015 |
| NCT01835054 | Unknown status | Determinants of the Progression and Outcome of Mitral Regurgitation | December 2008 | March 2024 | |
| NCT04443218 | Unknown status | Edwards PASCAL Transcatheter Valve Repair System Registry | May 27, 2019 | December 31, 2022 | |
| NCT02371512 | Unknown status | N/A | A Multicenter, Randomized, Controlled Study to Assess Mitral vAlve reconsTrucTion for advancEd Insufficiency of Functional or iscHemic ORigiN | February 2015 | December 2019 |
| NCT04518709 | Unknown status | N/A | The Effect of Posterior Annulus Elevation Technique in Reducing Residual Regurgitation During Mitral Valve Repair in Children | August 17, 2020 | August 17, 2022 |
| NCT04067635 | Unknown status | Primary Mitral Regurgitation Repair | May 25, 2018 | June 2021 | |
| NCT03893578 | Unknown status | N/A | The Conveyor Study | April 2019 | February 2020 |
| NCT03525041 | Unknown status | N/A | Mitral Valve Repair Combined Coronary Artery Bypass Grafting(CABG) Verus CABG Alone on Functional Ischemic Mitral Regurgitation | May 1, 2017 | June 30, 2020 |
| NCT00443365 | Unknown status | N/A | Should we Repair Ischemic Mitral Regurgitation? | March 2007 | |
| NCT02806570 | Unknown status | N/A | The CorCinch - Functional Mitral Valve Regurgitation (FMR) Study | August 2016 | March 2024 |
| NCT04770961 | Unknown status | N/A | Erector Spinae Plane Block for Minimally Invasive Mitral Valve Surgery | April 1, 2021 | August 30, 2022 |
| NCT03024268 | Unknown status | N/A | MitraClip® and Hemodynamic Effects of Relevant Iatrogenic Atrial Septum Defect Closure | January 2016 | December 2021 |
| NCT03012178 | Unknown status | MRI as a Predictor of Outcomes in Patients Undergoing Mitral Valve Surgery | January 2017 | December 2020 | |
| NCT05034471 | Unknown status | N/A | Mi-STITCH™ and Mi-KNOT™ Device Technologies - Improvement of Mitral Valve Repair | August 5, 2021 | April 2023 |
| NCT05425628 | Unknown status | N/A | European FIH Study - NeoChord Transcatheter Mitral Repair System for Symptomatic Mitral Regurgitation | August 1, 2022 | December 1, 2023 |
| NCT04709042 | Withdrawn | N/A | Acquisition of Objective Data During Transapical Neochordae Implantation | May 1, 2021 | May 1, 2024 |
| NCT00483236 | Withdrawn | Prospective Study Looking at Quality of Life Measures in Non-ischaemic Cardiomyopathy After Mitral Valve Repair | December 1, 2007 | June 1, 2009 | |
| NCT02624960 | Withdrawn | N/A | Safety and Performance of the AccuCinch® System | September 2016 | September 2019 |
| NCT02444286 | Withdrawn | The RESHAPE-HF1-FU Study | January 2017 | January 2018 |
- Disase is a (Disease Ontology)
- DOID:61
- Cross Reference ID (Disease Ontology)
- ICD10CM:Q23.3
- Cross Reference ID (Disease Ontology)
- ICD9CM:396.3
- Cross Reference ID (Disease Ontology)
- ICD9CM:746.6
- Cross Reference ID (Disease Ontology)
- MESH:D008944
- Cross Reference ID (Disease Ontology)
- NCI:C50888
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:194736003
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:194977007
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:29928006
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0026266
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0158619
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0264774
- Exact Synonym (Disease Ontology)
- Congenital insufficiency of mitral valve
- Exact Synonym (Disease Ontology)
- congenital mitral insufficiency
- Exact Synonym (Disease Ontology)
- congenital mitral regurgitation
- Exact Synonym (Disease Ontology)
- mitral regurgitation
- Exact Synonym (Disease Ontology)
- Mitral valve incompetence
- MeSH unique ID (MeSH (Medical Subject Headings))
- D008944