hypothyroidism
Information
- Disease name
- hypothyroidism
- Disease ID
- DOID:1459
- Description
- "A thyroid gland disease which involves an underproduction of thyroid hormone." [url:https\://medlineplus.gov/hypothyroidism.html]
Disease area statistics
Chromosome band
| Gene symbol | Chromosome | Start | Stop | The number of variant |
|---|---|---|---|---|
| SLC5A5 | 19 | 17,871,945 | 17,895,174 | 12 |
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT05412979 | Active, not recruiting | Phase 2 | A Study Evaluating the Safety and Efficacy of Hormone Replacement Therapy With ST-1891 Compared to Levothyroxine in Patients With Primary Hypothyroidism | April 29, 2022 | December 2023 |
| NCT05821881 | Active, not recruiting | REduction of LEvothyroxine in Adults; a SElf Controlled Study | February 13, 2020 | January 1, 2024 | |
| NCT05823012 | Active, not recruiting | Phase 2 | Study of XP-8121 For the Treatment of Adult Subjects With Hypothyroidism | April 21, 2023 | May 31, 2024 |
| NCT03779906 | Active, not recruiting | Phase 4 | Thyroid Function of Pediatric Subjects Following Isovue® Administration | March 26, 2019 | January 31, 2025 |
| NCT00205348 | Completed | Swallowing Function Before and After Surgery for Thyroid Goiter | April 2002 | January 2009 | |
| NCT00230802 | Completed | N/A | Thyroid Hormone Dose Adjustment in Pregnancy | July 2005 | July 2010 |
| NCT00336102 | Completed | Thyroid Dysfunction in Women With Newly Diagnosed Breast Cancer Compared to Healthy Volunteers | April 2006 | June 2015 | |
| NCT00403390 | Completed | N/A | Generic vs. Name-Brand Levothyroxine | November 2006 | March 2010 |
| NCT00524238 | Completed | N/A | Metabolic Changes in Hypothyroid Patients | March 2004 | August 2006 |
| NCT00565864 | Completed | Phase 4 | Neurocognitive and Metabolic Effects of Mild Hypothyroidism | August 2008 | August 2013 |
| NCT00715572 | Completed | N/A | Combined Therapy With L-Thyroxine and L-Triiodothyronine Compared to L-Thyroxine Alone | March 2002 | May 2004 |
| NCT00747760 | Completed | TSH Receptor Mutations Among a Consanguineous Community | December 2005 | December 2006 | |
| NCT01769157 | Completed | Phase 4 | Effects of L-carnitine on Hypothyroidism | August 2012 | June 2013 |
| NCT00001730 | Completed | Phase 4 | Study of Radioiodine (131-I) Uptake Following Administration of Thyrogen and Hypothyroid States During Thyroid Hormone Withdrawal. | December 1997 | April 2000 |
| NCT00005184 | Completed | Immunogenetic Factors of Coronary Heart Disease | December 1985 | November 1989 | |
| NCT00094237 | Completed | Subclinical Thyroid Dysfunction and Risk of Myocardial Infarction and Stroke | September 2004 | July 2007 | |
| NCT00818896 | Completed | Maternal Hypothyroidism in Pregnancy | April 2008 | September 2011 | |
| NCT01050465 | Completed | N/A | MedlinePlus Health Prescriptions: Developing a Pragmatic Approach for Clinic Use | May 2009 | December 2010 |
| NCT01197183 | Completed | Observational Study With Prospective and/or Retrospective Follow-up, Without Modifying Patient Treatment and Follow-up Practices for the Initial Treatment of Hypothyroidism in France | October 2008 | September 2009 | |
| NCT01536678 | Completed | Phase 4 | Bioequivalence of Two Levothyroxine Tablet Formulations in Healthy Indian Volunteers | January 2012 | April 2012 |
| NCT01647750 | Completed | Phase 4 | Study of Optimal Replacement of Thyroxine in the Elderly | August 2012 | August 2014 |
| NCT01800617 | Completed | Phase 2 | A Study of T3 Therapy in Patients With Hypothyroidism | March 2013 | |
| NCT01862510 | Completed | Detection of Celiac Disease in Patients With Hypothyroidism | March 2012 | December 2014 | |
| NCT01916304 | Completed | Phase 2 | Study of Dose Adjustment From Levothyroxine to a New Levothyroxine Sodium Test Formulation | July 2013 | June 2014 |
| NCT01921452 | Completed | Phase 4 | Study to Verify Clinical Utility of Point-of-Care (POC) Thyroid Stimulating Hormone (TSH) Test Kits as Compared to Third Generation TSH Test Kit | October 2013 | February 2014 |
| NCT01997554 | Completed | N/A | Validation of a New TSH Test | March 2012 | August 2014 |
| NCT02005250 | Completed | Bone Structure and Strength Evaluated by Extreme-CT Scan Before and After Treatment of Hyper- and Hypothyroidism | February 2012 | January 1, 2020 | |
| NCT02094079 | Completed | Monitoring and Evaluation of the Levothyroxin Replacement Therapy in Pregnant Women With Hypothyroidism | March 2014 | March 2015 | |
| NCT02190214 | Completed | Thyroid Disorders in Malaysia: A Nationwide Multicentre Study | August 2014 | September 2016 | |
| NCT02280330 | Completed | Phase 4 | Iodine Status of Preschoolers Given Micronutrient Powder for 6 Months | November 2014 | March 2015 |
| NCT02301520 | Completed | Vitamin D, Iodine, and Lead Levels in Haitian Infants and Children. | January 2015 | June 2015 | |
| NCT02364102 | Completed | Effect of Hypothyroidism on Brown Adipose Tissue | April 2015 | August 2017 | |
| NCT02467244 | Completed | Effect of Levothyroxine on Serum Adiponectin, Insulin Resistance and Cardiovascular Risk in Patients With Hypothyroidism | February 1, 2017 | December 30, 2018 | |
| NCT02499471 | Completed | N/A | Brown Adipose Tissue Activity and Thyroid Hormone | March 2012 | July 2014 |
| NCT02689609 | Completed | Post-radiation Hypothyroidism After IMRT for Nasopharyngeal Carcinoma | January 2008 | December 2016 | |
| NCT02710799 | Completed | N/A | Evaluation of the Effects of Teleconsultations on a Endocrinology Referral List | June 2015 | June 2016 |
| NCT02766283 | Completed | Observational Study on Hypothyroidism in Young Children Following Iodine Contrast Exposure | June 30, 2016 | August 30, 2016 | |
| NCT02891668 | Completed | Hypothyroidism, Metabolism and Quality of Life - Focus on QOL, REE, Cognitive Function and Body Composition | May 2015 | May 20, 2018 | |
| NCT02959827 | Completed | Iodinated Contrast Agents and Risk of Hypothyroidism in Young Children in the United States | October 15, 2016 | June 15, 2017 | |
| NCT02993562 | Completed | Hypothyroidism, Metabolism and Food Intake | August 2015 | August 30, 2018 | |
| NCT03053115 | Completed | Phase 2/Phase 3 | Combined Replacement Therapy With Levothyroxine and Liothyronine in Thyroidectomized Patients | March 14, 2017 | June 30, 2022 |
| NCT03095963 | Completed | N/A | Interaction Between Levothyroxine and Probiotics in Hypothyroid Patients | January 1, 2014 | October 25, 2016 |
| NCT03180892 | Completed | Non-immune Related Hypothyroidism in Iodine Sufficient Area | January 1, 2013 | December 31, 2016 | |
| NCT03342001 | Completed | Phase 4 | Hypothyroidism Treated With Calcitonin | June 18, 2018 | August 14, 2019 |
| NCT03465176 | Completed | N/A | The Effect of Aroma on Fatigue Scores Among Women With Hypothyroidism | July 11, 2017 | May 31, 2018 |
| NCT03612908 | Completed | TSHβX1 and D2 THR92ALA in Pregnancy | September 1, 2016 | June 30, 2018 | |
| NCT03627611 | Completed | Phase 2 | Identification of Non-responders to Levothyroxine Therapy | August 14, 2018 | June 22, 2020 |
| NCT03823859 | Completed | Metabolomics of Thyroid Hormones | December 12, 2018 | December 31, 2021 | |
| NCT03926585 | Completed | Variations in the DIO2 and MCT10 Genes and Effect of Triiodothyronine Treatment | April 23, 2019 | August 1, 2022 | |
| NCT03988517 | Completed | N/A | Comparing Two-time Points of Thyroid Hormone Replacement During the Holy Month of Ramadan | February 1, 2017 | January 8, 2018 |
| NCT04098991 | Completed | Improving White Matter Integrity With Thyroid Hormone | November 8, 2017 | November 8, 2019 | |
| NCT04124705 | Completed | Phase 2 | A Study of Armour® Thyroid Compared to Synthetic T4 (Levothyroxine) in Previously Hypothyroid Participants | October 11, 2019 | June 22, 2021 |
| NCT04332770 | Completed | Biosignals by Wearable Devices in Hypothyroidism | June 14, 2019 | October 15, 2020 | |
| NCT04528225 | Completed | A Prospective Study of Hypothyroidism After Radiotherapy for Breast Cancer | November 15, 2017 | February 24, 2020 | |
| NCT04648722 | Completed | Higher Levothyroxine Requirements After Right-side Hemithyroidectomy | May 5, 2020 | June 12, 2020 | |
| NCT04682340 | Completed | Analysis of BPA Concentration in Serum in Women of Reproductive Age With Autoimmune Thyroid Disease | December 22, 2020 | January 19, 2022 | |
| NCT04782856 | Completed | Phase 2 | Energy Metabolism in Thyroidectomized Patients | October 28, 2020 | April 19, 2023 |
| NCT04860622 | Completed | Normal Range of TSH and FT4 in Pregnancy | April 1, 2021 | September 1, 2021 | |
| NCT04877665 | Completed | Establishing RIs for TSH in Children Under the Age of Two Years | August 1, 2018 | March 30, 2019 | |
| NCT05015725 | Completed | The Relationship Between Serum rT3 Concentrations, T3/T4 Ratio, and Symptoms/Quality of Life in Treated Hypothyroid Patients | August 1, 2021 | August 31, 2022 | |
| NCT05033496 | Completed | The Yield of Postnatal Thyroid Function Test in the Well Baby Nursery | January 1, 2011 | October 3, 2021 | |
| NCT05070091 | Completed | The Impact of Pituitary-thyroid and Pituitary-adrenal Axes Function on COVID-19 Clinical Course. | January 26, 2021 | December 1, 2021 | |
| NCT05314790 | Completed | Management of Patients With Diagnosis of Hypothyroidism, as Hospitalized and as Outpatients, in Internal Medicine Units: Observational Study Before & After Educational Programme | June 1, 2016 | January 1, 2019 | |
| NCT05385029 | Completed | Fetal and Neonatal Thyroid in Pregnancies With Severe Acute Respiratory Syndrome Coronavirus 2 ( SARS- COV2 ) COVID-19 | May 1, 2020 | September 30, 2021 | |
| NCT05581147 | Completed | Thyroid Function and Structure IN Klinefelter Syndrome | May 11, 2007 | October 1, 2022 | |
| NCT06408909 | Completed | N/A | Pharmacist Role in Thyroid Disorders | March 15, 2022 | September 15, 2022 |
| NCT06452823 | Enrolling by invitation | Efficacy and Safety of Catheter Ablation of Atrial Fibrillation in Patients With Thyroid Hormone Stabilization | May 1, 2024 | June 30, 2026 | |
| NCT05712421 | Enrolling by invitation | Phase 2 | A Study Evaluation the Safety and Efficacy of Hormone Replacement Therapy With North Star Compared to Levothyroxine in Patients With Primary Hypothyroidism | February 28, 2023 | November 2024 |
| NCT05760131 | Not yet recruiting | Awareness of Osteoporosis in Patients With Hypothyroidism | July 1, 2023 | August 1, 2024 | |
| NCT05334771 | Not yet recruiting | Early Detection of Endolymphatic Hydrops in Hypothyroid Patients | September 2022 | April 2025 | |
| NCT06455371 | Not yet recruiting | N/A | Patient-centered Dosage of Levothyroxine | August 2024 | December 2027 |
| NCT06096454 | Not yet recruiting | Phase 4 | Effect of Life Style Modification and Metformin on Hypothyroidism With Insulin Resistance | November 20, 2023 | October 30, 2024 |
| NCT05975866 | Not yet recruiting | N/A | The Effects of an Anti-inflammatory Diet With or Without Curcumin Supplementation on Anthropometric Measurements, Concentrations of Thyroid Hormones, Anti-TPO, and Systemic Inflammation in Plasma and NFK-B in Peripheral Blood Mononuclear Cells in Patients With Hashimato | September 23, 2023 | June 30, 2025 |
| NCT06083636 | Recruiting | Improvement of Laboratory Diagnostics in Hypothyroid Patients Using Levothyroxine | July 26, 2022 | June 2025 | |
| NCT06268600 | Recruiting | N/A | The Protection of Thyroid Function in IMRT for Nasopharyngeal Carcinoma | January 1, 2019 | November 30, 2025 |
| NCT06205303 | Recruiting | N/A | Interventional Study to Improve Medication Adherence Using Patient Decision Aid | March 15, 2024 | March 31, 2025 |
| NCT06179368 | Recruiting | Throid Dysfunction in Liver Failure and Its Eddects Upon Outcome | January 1, 2024 | May 1, 2024 | |
| NCT05708456 | Recruiting | N/A | The Effect of Mobile Application on Hypothyroid Patients | February 15, 2023 | December 30, 2023 |
| NCT06015620 | Recruiting | Comorbidities Resolution After MGB Surgery and Change in Body Composition | September 1, 2023 | September 30, 2026 | |
| NCT06073665 | Recruiting | Phase 4 | Dosing of LT4 in Older Individuals | January 31, 2024 | April 1, 2028 |
| NCT04784208 | Recruiting | A Study to Determine the Validity and Sensitivity of 'Questionnaire to Screen for HYpothyroidism' (Q'SHY) | January 18, 2021 | December 31, 2022 | |
| NCT05733078 | Recruiting | Phase 2 | Effect of Vitamin C Supplementation in Patients With Primary Hypothyroidism | November 1, 2023 | June 2024 |
| NCT04806269 | Recruiting | Biosignals by Wearables in Thyroid Dysfunction | January 18, 2021 | December 31, 2023 | |
| NCT04831957 | Recruiting | N/A | Hypothyroidism After the TAVI Procedure in Elderly Patients | July 26, 2021 | December 31, 2023 |
| NCT00001159 | Recruiting | Natural History of Thyroid Function Disorders | February 1, 1977 | ||
| NCT06345339 | Recruiting | Phase 2/Phase 3 | A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants | April 26, 2024 | June 3, 2028 |
| NCT03977207 | Recruiting | N/A | A Randomized Controlled Trial of Thyroid Hormone Supplementation in Hemodialysis Patients | July 20, 2020 | April 30, 2025 |
| NCT00206375 | Terminated | Phase 4 | Growth Hormone and GnRH Agonist in Adolescents With Acquired Hypothyroidism | May 2003 | November 2011 |
| NCT04747275 | Terminated | Phase 4 | Use of Liquid Stable Levothyroxine in Trisomy 21 Pediatric Patients | January 18, 2021 | November 1, 2021 |
| NCT00770016 | Terminated | N/A | Insulin Sensitivity and Metabolism Before and After Treatment in Patients With Hypothyroidism | January 2010 | January 2011 |
| NCT00488644 | Terminated | N/A | Combined Levothyroxine/Liothyronine Supplementation in Hypothyroid Patients With Brain Tumors | February 2006 | March 2010 |
| NCT02567877 | Terminated | Is Levothyroxine Alone Adequate Thyroid Hormone Replacement? | November 2016 | June 2020 | |
| NCT04878614 | Terminated | Phase 4 | Comparison of Levothyroxine Formulation in Hypothyroid Patients With Enteral Feeding | May 5, 2021 | February 16, 2022 |
| NCT03496363 | Unknown status | Hypothyroidism With Congenital Heart Disease (CHD) | May 1, 2018 | May 1, 2020 | |
| NCT05421468 | Unknown status | N/A | Timing of Thyroxine Dose In Ramadan | March 14, 2022 | October 30, 2022 |
| NCT03754621 | Unknown status | Upper Limit for TSH of First and Second Trimester Pregnancy in Turkey | October 15, 2018 | July 15, 2019 | |
| NCT01105923 | Unknown status | N/A | Study of an Intervention to Improve Problem List Accuracy and Use | May 2010 | November 2017 |
| NCT01145040 | Unknown status | NOMOTHETICOS: Nonlinear Modelling of Thyroid Hormones' Effect on Thyrotropin Incretion in Confirmed Open-loop Situation | June 1, 2010 | January 31, 2021 | |
| NCT01204359 | Unknown status | Phase 3 | The Prospective Study of Standard Treatment of Graves Disease Iodine 131 and Prevention of Adverse Reactions | July 2007 | December 2016 |
| NCT01358136 | Unknown status | ThyrOp: A Study of Individual Subclinical Hypothyroidism After Hemithyroidectomy for Benign Nontoxic Goiter | May 2011 | December 2013 | |
| NCT01379170 | Unknown status | Phase 4 | Thyroid Study Type 2 Diabetes Mellitus (T2DM) | June 2011 | December 2014 |
| NCT01744743 | Unknown status | N/A | Preconceptional Thyroid Screening and Childhood Nerocognitive Function | January 2011 | December 2015 |
| NCT01744769 | Unknown status | Effects of Thyroid Hormone Withdrawal on Metabolic Parameters During Radioactive Iodine Therapy in Thyroid Cancer | July 2012 | May 2013 | |
| NCT01831869 | Unknown status | Phase 4 | Effect of L-Thyroxine on Lipid Profiles and Atherosclerosis in Subclinical Hypothyroidism | April 2013 | April 2022 |
| NCT01848171 | Unknown status | Phase 4 | Effects of L-thyroxine Replacement on Serum Lipid and Atherosclerosis in Hypothyroidism | July 2013 | July 2023 |
| NCT04236232 | Unknown status | The Impact of Subclinical Hypothyroidism on Cardiovascular System | February 1, 2020 | June 1, 2021 | |
| NCT00111735 | Unknown status | Phase 4 | Thyroxine Titration Study | April 2003 | March 2005 |
| NCT04795947 | Unknown status | Correlation Between Thyroid Function and Quality of Life in Hypothyroidism | November 1, 2020 | November 1, 2021 | |
| NCT02317926 | Unknown status | N/A | Desiccated Thyroid Extract Versus Synthetic T3/T4 Combination (ThyrolarTM) Versus L-T4 Alone in the Therapy of Primary Hypothyroidism With Special Attention to the Gene Polymorphism | May 2015 | |
| NCT02512978 | Unknown status | Phase 4 | Thyroid Hormone Replacement for Hypothyroidism and Acute Myocardial Infarction(ThyroHeart-AMI) | August 2015 | June 2019 |
| NCT02917863 | Unknown status | Phase 4 | Randomized Crossover Trial for the Evaluation of the Possible Effects in the Intestine of Two Different Pharmaceutical Forms of L - Thyroxine in Patients With Primary Acquired Hypothyroidism | May 2016 | May 2019 |
| NCT05143918 | Unknown status | Quality of Life Among Egyptian Hypothyroid Patients | December 31, 2021 | December 30, 2023 | |
| NCT05240911 | Unknown status | N/A | Individual Dosing of Levothyroxine After Thyroidectomy | June 1, 2022 | June 10, 2023 |
| NCT05247476 | Unknown status | Phase 4 | Type 2 Deiodinase Gene Polymorphism and the Treatment of Hypothyroidism Caused by Thyroidectomy in Thyroid Cancer Patients. | October 18, 2021 | September 2022 |
| NCT03257566 | Unknown status | Hypothyroidism in Patients With Type 1 Diabetes | November 2017 | September 2019 | |
| NCT03631771 | Withdrawn | Phase 4 | Pediatric Risk of Hypothyroidism With Iodinated Contrast Media | March 2022 | February 2025 |
| NCT02577367 | Withdrawn | Phase 4 | Mean Percentage of Levothyroxine Dosage Increase in Patients With Hypothyroidism Started on Enteral Feeding | October 1, 2015 | April 8, 2020 |
| NCT01801033 | Withdrawn | Effects of Thyroid Hormone Enzyme Blocking on Hypothyroidism | January 4, 2013 | November 29, 2013 | |
| NCT02548715 | Withdrawn | Phase 2/Phase 3 | Levothyroxine Treatment for Subclinical Hypothyroidism After Head and Neck Surgery | July 2015 | July 2017 |
| NCT00287144 | Withdrawn | Post Partum Thyroiditis 2: Long Term Observations | January 2014 | December 2016 | |
| NCT01707056 | Withdrawn | N/A | The Effect of Coffee on the Absorption of Thyroid Hormone in Patients With Thyroid Carcinoma | September 2012 | June 2016 |
- Disase is a (Disease Ontology)
- DOID:50
- Cross Reference ID (Disease Ontology)
- EFO:0004705
- Cross Reference ID (Disease Ontology)
- ICD10CM:E03.9
- Cross Reference ID (Disease Ontology)
- ICD9CM:244.9
- Cross Reference ID (Disease Ontology)
- MESH:D007037
- Cross Reference ID (Disease Ontology)
- NCI:C26800
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:267465007
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0020676
- Exact Synonym (Disease Ontology)
- Thyroid deficiency
- Exact Synonym (Disease Ontology)
- Thyroid insufficiency
- HPO alt_id (Human Phenotype Ontology)
- HP:0003222
- HPO alt_id (Human Phenotype Ontology)
- HP:0008203
- HPO Human Phenotype ID (Human Phenotype Ontology)
- HP:0000821
- MeSH unique ID (MeSH (Medical Subject Headings))
- D007037