Hypercholesterolemia, Familial
Information
- Disease name
- Hypercholesterolemia, Familial
- Disease ID
- Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT04837638 | Active, not recruiting | Diet Quality and Coronary Artery Calcification in Adults With Heterozygous Familial Hypercholesterolemia | July 1, 2021 | December 31, 2024 | |
| NCT00005168 | Completed | Hyperapo B and Coronary Heart Disease | August 1984 | December 1991 | |
| NCT00134485 | Completed | Phase 3 | Study To Evaluate The Safety And Efficacy Of Torcetrapib/Atorvastatin In Subjects With Familial Hypercholerolemia | March 2005 | March 2006 |
| NCT00134511 | Completed | Phase 3 | Study To Evaluate The Effect Of Torcetrapib/Atorvastatin In Patients With Genetic High Cholesterol Disorder | March 2005 | November 2005 |
| NCT00136981 | Completed | Phase 3 | Carotid B-Mode Ultrasound Study to Compare Anti-Atherosclerotic Effect of Torcetrpib/Atorvastatin to Atorvastatin Alone. | December 2003 | November 2006 |
| NCT00280995 | Completed | Phase 2 | Dose-escalating Safety Study of ISIS 301012 in Homozygous Familial Hypercholesterolemia Subjects on Lipid Lowering Therapy | January 2006 | August 2007 |
| NCT00281008 | Completed | Phase 2 | Study of ISIS 301012 (Mipomersen) in Heterozygous Familial Hypercholesterolemia Subjects on Lipid Lowering Therapy | February 2006 | December 2007 |
| NCT00000594 | Completed | Phase 3 | NHLBI Type II Coronary Intervention Study | November 1971 | November 1976 |
| NCT01753232 | Completed | Safety and Efficacy of the DALI LDL-adsorber and MONET Lipoprotein Filter | May 2012 | August 2015 | |
| NCT03018678 | Completed | Screening Protocol for a Gene Therapy Trial in Subjects With Homozygous Familial Hypercholesterolemia | March 2016 | December 3, 2019 | |
| NCT03795038 | Completed | N/A | Comparison of the Plasma Lipoprotein Apheresis Systems DIAMED and MONET vs. the Whole Blood Apheresis System DALI | December 28, 2018 | May 25, 2021 |
| NCT04118348 | Completed | N/A | Evaluating the Efficacy of Pediatric Lipid Screening Alerts | October 10, 2019 | October 11, 2020 |
| NCT04526457 | Completed | N/A | Is Family Screening Improved by Genetic Testing of Familial Hypercholesterolemia | November 1, 2014 | April 1, 2017 |
| NCT04722068 | Completed | N/A | Regeneron 1331 Kinetics Sub-Study HoFH | October 7, 2016 | January 1, 2021 |
| NCT06231459 | Completed | Phase 4 | Expression of Pro- and Anti-inflammatory Cytokines During Anti-PCSK9 in Familial Hypercholesterolemia | January 1, 2019 | December 31, 2020 |
| NCT00515307 | Completed | Phase 1 | Bone Marrow Stem Cells as a Source of Allogenic Hepatocyte Transplantation in Homozygous Familial Hypercholesterolemia | June 2007 | June 2008 |
| NCT01375751 | Completed | Phase 2 | Reduction of Low-Density Lipoprotein Cholesterol (LDL-C) With PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder Study | August 2, 2011 | May 16, 2012 |
| NCT01524289 | Completed | Phase 3 | Study to Assess the Tolerability and Efficacy of Anacetrapib (MK-0859) Co-Administered With Statin in Participants With Heterozygous Familial Hypercholesterolemia (MK-0859-020) | February 3, 2012 | November 13, 2018 |
| NCT04073797 | Recruiting | N/A | PET Imaging of Inflammation and Lipid Lowering Study | March 20, 2023 | March 1, 2025 |
| NCT03989167 | Recruiting | N/A | Clinical Decision Support for Familial Hypercholesterolemia | December 6, 2022 | June 6, 2025 |
| NCT04656028 | Recruiting | N/A | Genetic Testing and Motivational Counseling for FH | June 15, 2020 | March 30, 2025 |
| NCT04313270 | Recruiting | Subclinical Atherosclerosis in Patients With Familial Hypercholesterolemia Treated With Evolocumab® | December 1, 2017 | December 1, 2025 | |
| NCT00092833 | Terminated | Phase 3 | Investigational Drug in Patients With Hypercholesterolemia or in Patients With Sitosterolemia (0653-026)(COMPLETED) | July 2002 | May 2005 |
| NCT01583647 | Terminated | Phase 1 | A Study of Extended-release (ER) Niacin/Laropiprant in Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0524A-158) | June 2012 | December 2012 |
| NCT00384293 | Terminated | Phase 3 | Carotid IMT (Intima Media Thickening) Study (0524A-041)(TERMINATED) | September 2006 | August 2008 |