Giant Cell Tumor of Bone

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Information
Disease name
Giant Cell Tumor of Bone
Disease ID
Description
Disease area statistics
Chromosome band
Gene symbol Chromosome Start Stop The number of variant
H3-3A 1 226,063,977 226,072,001 2
APC 5 112,737,885 112,846,239 2
MUTYH 1 45,329,242 45,340,440 2
ABL1 9 130,713,043 130,887,675 2
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT04255576 Active, not recruiting Phase 1/Phase 2 Efficacy and Safety of JMT103 in Patients With Giant Cell Tumor of Bone October 10, 2019 October 2023
NCT03449108 Active, not recruiting Phase 2 LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Anaplastic Thyroid Cancer, Osteosarcoma, or Other Bone and Soft Tissue Sarcomas April 27, 2018 June 30, 2025
NCT00680992 Completed Phase 2 Study of Denosumab in Subjects With Giant Cell Tumor of Bone September 9, 2008 May 17, 2018
NCT00396279 Completed Phase 2 Safety and Efficacy Study of Denosumab in Patients With Recurrent or Unresectable Giant Cell Tumor of Bone July 10, 2006 February 1, 2011
NCT02996734 Completed Giant Cell Tumor of the Extremities Treated With Surgery and/or Medical Treatment April 2016 December 2016
NCT05402865 Completed A Real-world Study on Patients of Unresectable Giant Cell Tumor of Bone November 10, 2021 February 18, 2022
NCT03301857 Completed Phase 4 Long-term Safety Follow-up of Subjects With Giant Cell Tumor of Bone Treated With Denosumab in Study 20062004 November 13, 2017 July 27, 2023
NCT04002817 Completed Giant Cell Tumor of the Bone in Young Patients June 5, 2019 June 30, 2020
NCT00464620 Completed Phase 2 Trial of Dasatinib in Advanced Sarcomas May 2007 May 2017
NCT05813665 Not yet recruiting Phase 3 A Study to Evaluate the Efficacy and Safety of Narlumosbart (JMT103) in Patients With Giant Cell Tumor of Bone April 2023 September 2028
NCT03295981 Recruiting Phase 3 Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone May 3, 2018 January 2026
NCT04586660 Recruiting Phase 4 Study of XGEVA® (Denosumab) in Chinese Adults and Skeletally Mature Adolescents With Giant Cell Tumor of the Bone August 17, 2023 October 16, 2027
NCT05595603 Recruiting Phase 2 Zoledronic Acid-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Bone Tumor After Intralesional Curettage March 2023 December 1, 2026
NCT00889590 Terminated Phase 2 Adjuvant Zoledronic Acid in High Risk Giant Cell Tumour of Bone (GCT) December 2008 July 2015
NCT03358212 Unknown status Safety and Efficacy of Post-operative Denosumab Strategy for Giant Cell Tumor of Bone Treatment in China March 1, 2018 June 1, 2021
NCT03259152 Unknown status Phase 3 Characteristics and Mechanism of Denosumab-treated Giant Cell Tumor of Bone May 1, 2016 May 1, 2019
HPO Human Phenotype ID (Human Phenotype Ontology)
HP:0011847
MeSH unique ID (MeSH (Medical Subject Headings))
D018212