Chagas disease
Information
- Disease name
- Chagas disease
- Disease ID
- DOID:12140
- Description
- "A trypanosomiasis that is a tropical parasitic disease caused by the flagellate protozoan Trypanosoma cruzi, which is transmitted to humans and other mammals by an insect vector, the blood-sucking assassin bugs of the subfamily Triatominae (family Reduviidae), most commonly species belonging to the Triatoma, Rhodnius, and Panstrongylus genera. The symptoms include fever, fatigue, body aches, headache, rash, loss of appetite, diarrhea, vomiting, swelling of the eyelids and myocarditis." [url:http\://en.wikipedia.org/wiki/Chagas_disease]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT04023227 | Active, not recruiting | Phase 4 | Efficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Change in Patients With CCC | December 10, 2019 | September 16, 2024 |
| NCT03981523 | Active, not recruiting | Phase 2 | New Therapies and Biomarkers for Chagas Infection | December 18, 2019 | July 31, 2025 |
| NCT04024163 | Active, not recruiting | Phase 3 | Prospective Study of Benznidazole for Chagas' Disease Children With Chronic Indeterminate Chagas Disease | September 19, 2019 | March 30, 2028 |
| NCT04274101 | Active, not recruiting | Nifurtimox Versus Benznidazole Effectiveness and Tolerance for Chagas Disease Treatment | June 1, 2018 | February 1, 2025 | |
| NCT00699387 | Completed | N/A | Population Pharmacokinetics of Benznidazole in Children With Chagas Disease | April 2007 | May 2011 |
| NCT01006473 | Completed | Phase 4 | Exercise Training in Chagas Cardiomyopathy | March 2007 | March 2009 |
| NCT01006486 | Completed | Phase 4 | Outcomes of an Anticoagulation Clinic in an University Hospital | November 2009 | August 2011 |
| NCT01162967 | Completed | Phase 2 | Clinical Trial For The Treatment Of Chronic Chagas Disease With Posaconazole And Benznidazole | September 2010 | March 2013 |
| NCT01377480 | Completed | Phase 2 | A Study of the Use of Oral Posaconazole (POS) in the Treatment of Asymptomatic Chronic Chagas Disease (P05267) | July 6, 2011 | January 12, 2015 |
| NCT01547533 | Completed | Study of Benznidazole Transfer Into Breastmilk in Lactating Women With Chagas Disease | August 2011 | December 2013 | |
| NCT00005455 | Completed | Chagas Disease as an Undiagnosed Type of Cardiomyopathy in the United States | January 1993 | December 1993 | |
| NCT01678599 | Completed | Phase 4 | Optimization of PCR Technique to Assess Parasitological Response for Patients With Chronic Chagas Disease | April 2011 | April 2013 |
| NCT01681420 | Completed | N/A | Improving Blood Safety and HIV Testing in Brazil | August 1, 2012 | January 31, 2015 |
| NCT01744405 | Completed | Study Of Nifurtimox Transfer Into Breastmilk In Lactating Women With Chagas Disease | December 2012 | March 2015 | |
| NCT01755377 | Completed | New Tools for the Diagnosis, Prognosis and Treatment Follow-up in Chagas Disease | December 2012 | June 2016 | |
| NCT01755403 | Completed | Phase 4 | Population Pharmacokinetics in Benznidazole-treated Adults With Chronic With Chagas Disease | December 2012 | November 2013 |
| NCT01787968 | Completed | Congenital Transmission of Lineages I and II of Trypanosoma Cruzi | April 2011 | December 2013 | |
| NCT01842854 | Completed | Galectin-3 as a Biomarker in Patients With Chagas Disease | January 2011 | June 2015 | |
| NCT01842867 | Completed | Syndecan-4 as a Biomarker in Patients With Chagas Disease | January 2011 | June 2015 | |
| NCT01842880 | Completed | MicroRNAs as Biomarkers in Patients With Chagas Disease | January 2011 | December 2013 | |
| NCT01874795 | Completed | N/A | Effect of Ganglionar Electrical Stimulation on Central Arterial Pressure | March 2012 | June 2012 |
| NCT01927224 | Completed | Phase 1 | Study to Assess Bioequivalence of 30 and 120 mg Nifurtimox Tablets in Chronic Chagas' Patients | November 2013 | September 2014 |
| NCT02327052 | Completed | Assessment of Speckle Tracking Strain Predictive Value for Myocardial Fibrosis in Chagas Disease | January 2011 | December 2013 | |
| NCT02346123 | Completed | Determination of Genetic Polymorphisms in Chronic Chagas Cardiomyopathy | June 2015 | June 2015 | |
| NCT01662362 | Completed | N/A | Abbott ESA Chagas Assay Post-Market Study | July 2012 | December 2012 |
| NCT00023556 | Completed | Genetic Architecture of Heart Disease in Rural Brazil | September 2001 | August 2008 | |
| NCT00123916 | Completed | Phase 3 | BENEFIT: Evaluation of the Use of Antiparasital Drug (Benznidazole) in the Treatment of Chronic Chagas' Disease | November 2004 | August 2015 |
| NCT00453700 | Completed | Prevalence of Chagas Disease in Immigrant Patients With Conduction Abnormalities on Electrocardiogram | January 2007 | December 2010 | |
| NCT02386358 | Completed | Phase 3 | Etiologic Treatment With Benznidazole in Adult Patients With Chronic Chagas Disease. A Randomized Clinical Trial | March 1999 | April 2013 |
| NCT02516293 | Completed | Phase 2/Phase 3 | Cardiac Rehabilitation in Chagas Heart Failure | May 2013 | December 2014 |
| NCT02517632 | Completed | Phase 3 | Physical Exercise Program in Chronic Chagas Heart Disease | March 2015 | January 2017 |
| NCT02606864 | Completed | Phase 1 | Study to Assess the Food Effect on the Pharmacokinetics of Nifurtimox Tablets in Chronic Chagas' Patients | December 2015 | August 2016 |
| NCT02625974 | Completed | Phase 3 | Prospective Study of a Pediatric Nifurtimox Formulation for Chagas' Disease | January 27, 2016 | August 10, 2021 |
| NCT02646943 | Completed | Longitudinal Study of Patients With Chronic Chagas Cardiomyopathy in Brazil (SaMi_Trop Project) | July 2013 | August 2014 | |
| NCT03191162 | Completed | Phase 2 | Evaluation of Different Benznidazole Regimens for the Treatment of Chronic Chagas Disease. | April 21, 2017 | March 16, 2021 |
| NCT03350295 | Completed | Phase 1 | Study Will Evaluate the Relative Bioavailability, Safety, and Tolerability of Single Doses of Nifurtimox 30 mg Tablets Exhibiting Different in Vitro Dissolution Characteristics, and to Evaluate the Relative Bioavailability of Nifurtimox 30 mg and 120 mg | June 14, 2018 | December 14, 2018 |
| NCT03892213 | Completed | Phase 1 | Pharmacokinetic Drug-Drug Interaction Study | October 2014 | January 2015 |
| NCT04090489 | Completed | Congenital Chagas Disease: Long Term Follow up of Treated Children. Preliminary Report or Cardiological Evaluation in Chagas Disease Treated Children | January 22, 2015 | March 1, 2020 | |
| NCT05477953 | Not yet recruiting | An Observational Pregnancy Safety Study in Women Who Were Exposed to the Drug Nifurtimox During Pregnancy to Learn About the Risk of Pregnancy Complications and About the Mother's and Baby's Health | June 30, 2024 | January 31, 2032 | |
| NCT04084379 | Recruiting | Implementation Strategy of Bio-molecular Techniques for Early Diagnose of Congenital Syphilis and Chagas Diseases | July 1, 2019 | September 1, 2024 | |
| NCT05868005 | Recruiting | N/A | Delivering a Multi-disease Screening Tool to Migrant Populations | October 23, 2023 | September 2024 |
| NCT03672487 | Recruiting | Phase 3 | Short-course Benznidazole Treatment to Reduce Trypanosoma Cruzi Parasitic Load in Women of Reproductive Age | June 1, 2019 | May 31, 2025 |
| NCT04897516 | Recruiting | Phase 3 | Shorter Benznidazole Regimens Compared to the Standard Regimen for Chagas Disease | July 28, 2021 | December 1, 2026 |
| NCT01539161 | Terminated | Phase 4 | Reveal Chagas: Clinical Evidence of the Implantable Cardiac Monitor in Patients With Chagas Disease | July 2013 | April 2015 |
| NCT00875173 | Unknown status | Phase 3 | Selenium Treatment and Chagasic Cardiopathy (STCC) | October 2008 | December 2020 |
| NCT03378661 | Unknown status | Phase 2 | BENDITA BEnznidazole New Doses Improved Treatment and Associations | November 30, 2016 | July 27, 2018 |
| NCT04984265 | Unknown status | Phase 1/Phase 2 | SBRT in Chagas Disease Ventricular Tachycardia | July 14, 2021 | July 31, 2023 |
| NCT03704181 | Unknown status | Phase 2 | Colchicine for Patients With Chagas´ Disease( B1 Stage) | October 1, 2018 | January 5, 2021 |
| NCT02369978 | Unknown status | Phase 2/Phase 3 | CHICAMOCHA 3 - Equivalence of Usual Interventions for Trypanosomiasis (EQUITY) | August 2015 | February 2019 |
| NCT02295215 | Unknown status | N/A | Exercise Training in Patients With Chagasic Heart Disease Without Ventricular Dysfunction | June 2013 | December 2015 |
| NCT02498782 | Unknown status | Phase 2 | Study to Evaluate Fexinidazole Dosing Regimens for the Treatment of Adult Patients With Chagas Disease | July 2014 | February 2016 |
| NCT02099903 | Unknown status | N/A | Renal Denervation in Patients With Heart Failure Secondary to Chagas Disease | March 2014 | August 2015 |
- Disase is a (Disease Ontology)
- DOID:10113
- Cross Reference ID (Disease Ontology)
- GARD:6030
- Cross Reference ID (Disease Ontology)
- ICD9CM:086.2
- Cross Reference ID (Disease Ontology)
- KEGG:05142
- Cross Reference ID (Disease Ontology)
- MESH:D014355
- Cross Reference ID (Disease Ontology)
- ORDO:3386
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:77506005
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0041234
- Exact Synonym (Disease Ontology)
- Chagas' disease
- Exact Synonym (Disease Ontology)
- chagas' disease with digestive system involvement
- Exact Synonym (Disease Ontology)
- chagas' disease with nervous system involvement
- Exact Synonym (Disease Ontology)
- chagas' disease with other organ involvement
- Disase Synonym (Disease Ontology)
- American trypanosomiasis
- ICD10 preferred id (Insert disease from ICD10)
- D0000750
- ICD10 class code (Insert disease from ICD10)
- B57
- MeSH unique ID (MeSH (Medical Subject Headings))
- D014355