Septic Shock

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Information
Disease name
Septic Shock
Disease ID
Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT04855786 Active, not recruiting N/A External Drainage of Thoracic Duct Lymph to Reduce Inflammatory Cytokines in Septic Shock Patients January 13, 2022 January 2025
NCT05741762 Active, not recruiting Assessing Baseline Cortisol Levels in Patients Admitted With Septic Shock in Intensive Care Unit January 31, 2023 April 2024
NCT04143035 Active, not recruiting Hemodynamic Resuscitation and Monitoring in Early Sepsis October 22, 2019 January 31, 2023
NCT06214715 Active, not recruiting Renal Resistive Index in Septic Shock Patients October 20, 2023 December 2, 2024
NCT04257136 Active, not recruiting Phase 2 VBI-S for the Treatment of Hypotension in Hypovolemic Septic Shock Patients February 17, 2020 December 31, 2023
NCT02120404 Active, not recruiting Phase 2 Pilot Phase II Study: Hemodynamic Tolerance and Anti-inflammatory Effects of Esmolol During the Treatment of Septic Shock April 2015 October 2023
NCT06181604 Active, not recruiting Multicenter Symphony IL-6 Monitoring Sepsis ICU Study January 12, 2024 June 30, 2024
NCT05296590 Active, not recruiting Monocyte Distribution Width (MDW) in the General Population of Emergency Department Patients With and Without Bacteremia July 1, 2021 June 2026
NCT00197938 Completed Lactic Acid in the Rectum and Life-Threatening Infection November 2005 April 2009
NCT00207844 Completed Phase 2 Selenium, as Sodium Selenite, in the Treatment of Septic Shock January 2002 January 2005
NCT00273728 Completed Phase 4 BaSES Trial: Basel Starch Evaluation in Sepsis May 2005 May 2011
NCT00279214 Completed Phase 4 Hemodynamic and Perfusion Response to Drotrecogin Alfa (Activated) in Patients With Septic Shock November 2005 November 2007
NCT00320099 Completed Phase 3 Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock January 2006 February 2009
NCT00327704 Completed Phase 4 Early Albumin Resuscitation During Septic Shock July 2006 January 2011
NCT00329680 Completed Phase 4 The Effects of Eicosapentaenoic Acid (EPA), Gamma-Linolenic Acid (GLA) and Antioxidants in the Treatment of Sepsis June 2007 October 2009
NCT00372502 Completed N/A Clinical Trial of the Optimal Endpoint of Early Sepsis Resuscitation January 2007 December 2008
NCT00398736 Completed A Non-invasive Approach to the Assessment of Volume Status in Mechanically Ventilated Septic Patients.
NCT00407823 Completed N/A Comparison of Pediatric Septic Shock Treatment With and Without Central Venous Oxygen Saturation Monitoring January 2004 August 2005
NCT00481442 Completed Phase 2 Phenylephrine Versus Norepinephrine in Septic Shock January 2007 March 2007
NCT00481572 Completed Phase 2 Continuous Infusion of Terlipressin in Septic Shock January 2007 December 2007
NCT00493415 Completed Phase 3 The Effect of Nitroglycerine on Microcirculatory Abnormalities During Sepsis June 2007 July 2008
NCT00510835 Completed N/A Protocolized Care for Early Septic Shock March 2008 December 2013
NCT00523198 Completed Correlation Salivary Cortisol and Free Serum Cortisol to Total Serum Cortisol in MICU Septic Shock February 2007 October 2008
NCT00527007 Completed N/A External Cooling in Septic Shock Patients October 2007 March 2010
NCT00534287 Completed Phase 3 Comparison of Two Antibiotic Regimen (Meropenem Versus Meropenem+Moxifloxacin)in the Treatment of Severe Sepsis and Septic Shock October 2007 June 2010
NCT00541827 Completed Skeletal Muscle and Platelet Mitochondrial Dysfunction During Sepsis October 2007 August 2012
NCT00592488 Completed Phase 1/Phase 2 Acetyl-L-Carnitine in the Treatment of Septic Shock August 2006 September 2009
NCT00604019 Completed Phase 3 Dopamine Versus Norepinephrine for the Treatment of Vasopressor Dependent Septic Shock March 2003 August 2009
NCT00625209 Completed Phase 3 Activated Protein C and Corticosteroids for Human Septic Shock March 2008 July 2016
NCT00628160 Completed Phase 2/Phase 3 Terlipressin in Septic Shock in Cirrhosis October 2006 December 2012
NCT00629382 Completed Phase 4 Early Use of Polymyxin B Hemoperfusion in Abdominal Sepsis December 2004 April 2008
NCT00639015 Completed Phase 2 Phenylephrine in Septic Shock November 2007 June 2008
NCT00676897 Completed Phase 2/Phase 3 Statin Therapy in the Treatment of Sepsis February 2008 December 2010
NCT00698048 Completed Serial Vasopressin and Copeptin Levels in Children With Sepsis and Septic Shock August 2008 December 2011
NCT00707122 Completed Phase 3 Volume Replacement With Albumin in Severe Sepsis July 2008 October 2013
NCT00763906 Completed Phase 4 Norepinephrine Weaning in Septic Patients November 2004 January 2007
NCT00793442 Completed Endothelium in Severe Sepsis March 2008 May 2013
NCT00800306 Completed Phase 2 Effects of Levosimendan on Microcirculation in Septic Shock November 2007 April 2009
NCT00811629 Completed Influence of Acute Respiratory Distress Syndrome (ARDS) and Severe Sepsis on sRAGE Levels in ICU Patients January 2009 July 2009
NCT00001303 Completed Phase 1 Effects of Endotoxin in Normal Human Volunteers April 6, 1992 May 17, 2018
NCT00005890 Completed N/A Diagnostic Study of Adrenal Cortical Function in Children With Septic Shock March 1996
NCT00118664 Completed Patient Plasma Response and Outcome in Septic Shock With Thrombocytopenia Associated Multiple Organ Failure in Children May 2005 February 2012
NCT00134212 Completed Phase 2 Dopexamine and Norepinephrine Compared With Epinephrine Alone in Septic Shock March 2002 June 2004
NCT00135473 Completed Phase 3 Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial) April 2003 September 2005
NCT00148278 Completed Phase 2/Phase 3 Norepinephrine Plus Dobutamine Versus Epinephrine Alone for the Management of Septic Shock October 1999 December 2005
NCT00159952 Completed Phase 2/Phase 3 Effect of Hyperglycemia in PAI-1 Activity and the Relationship With Outcome in Severe Sepsis and Septic Shock November 2004 November 2007
NCT00197886 Completed N/A Dose of Norepinephrine and the Concentration of L-Lactate in the Rectum and Stomach in Patients With Septic Shock. October 2004 December 2005
NCT00819416 Completed Phase 2 Fluid Resuscitation in Early Septic Shock February 2009 February 2010
NCT00823108 Completed Phase 1 Rapid Administration of Insulin in Sepsis March 2009 October 2010
NCT00832039 Completed Phase 3 Placebo Controlled Trial of Sodium Selenite and Procalcitonin Guided Antimicrobial Therapy in Severe Sepsis November 2009 June 2013
NCT00835913 Completed Autonomic Nervous System Alteration Induce by Sepsis: Assessment and Prognosis Impact October 2008 September 2011
NCT00930085 Completed N/A Evaluation of Predictive Proteic Profile on Mortality in the Acute Phase of Septic Shock in Cancer Patients August 2008 May 2011
NCT00934011 Completed N/A Use of Inflammatory Biomarkers to Guide Antibiotic Therapy in Patients With Severe Infections September 2009 May 2012
NCT00962156 Completed Phase 3 Scandinavian Starch for Severe Sepsis/Septic Shock Trial December 2009 March 2012
NCT00995839 Completed Phase 2/Phase 3 Terlipressin in Septic Shock: Effects on Microcirculation November 2008 February 2010
NCT01000649 Completed Phase 2 Effects of the V1a Agonist FE 202158 in Patients With Septic Shock November 2009 September 2011
NCT01013662 Completed N/A Lipid Profile in Patients With Severe Sepsis or Septic Shock Under Strict or Liberal Glycemic Control January 2005 July 2007
NCT01046669 Completed N/A Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Septic Shock June 2010 June 2017
NCT01062685 Completed Near Infrared Spectroscopy (St02) January 2009 January 2010
NCT01067313 Completed Phase 2/Phase 3 Continuous Hemodialysis With an Enhanced Middle Molecule Clearance Membrane July 2008 January 2011
NCT01070810 Completed Phase 1/Phase 2 Thiamine as a Metabolic Resuscitator in Septic Shock February 2010 November 2014
NCT01071343 Completed N/A Transcutaneous Electric Muscle Stimulation (TEMS) in Septic Patients January 2008 April 2009
NCT01106300 Completed Musculoskeletal Ultrasound Study in Critical Care: Longitudinal Evaluation February 2009 December 2015
NCT01139489 Completed N/A Safety and Efficacy of Procalcitonin Guided Antibiotic Therapy in Adult Intensive Care Units (ICU's) November 2009 August 2014
NCT01144624 Completed Phase 2 A Study to Assess Safety,and Tolerability of 2 Doses of AZD9773 (CytoFab™) in Japanese With Severe Sepsis/Septic Shock July 2010 August 2011
NCT01145560 Completed Phase 2 A Study to Compare the Efficacy and Safety of 2 Dosing Regimens of IV Infusions of AZD9773 (CytoFab™) With Placebo in Adult Patients With Severe Sepsis and/or Septic Shock October 2010 May 2012
NCT01149278 Completed N/A Assessment of Two Levels of Arterial Pressure on Survival in Patients With Septic Shock March 2010 September 2012
NCT01188993 Completed Phase 4 Transpulmonary Thermodilution and Transesophageal Echocardiography in Early Septic Shock January 2011 December 2014
NCT01222663 Completed Phase 3 Effects of Hemoperfusion With a Polymyxin B Membrane in Peritonitis With Septic Shock October 2010 December 2013
NCT01223690 Completed Phase 3 Clarithromycin as Immunomodulator for the Management of Sepsis July 2007 April 2011
NCT01231698 Completed Phase 2 Heart Rate Control With Esmolol in Septic Shock December 2010 July 2012
NCT01263977 Completed N/A Thermodilution - Controlled Management of Volume Therapy in Septic Shock December 2010 May 2014
NCT01271153 Completed N/A Effects of Dobutamine on Microcirculation, Regional and Peripheral Perfusion in Septic Shock Patients August 2010 January 2013
NCT01280942 Completed N/A Early Warning System for Clinical Deterioration on General Hospital Wards January 2011 May 2012
NCT01284452 Completed N/A Efficacy of Hydrocortisone in Treatment of Severe Sepsis/Septic Shock Patients With Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS) December 2010 March 2015
NCT01319630 Completed The Effect of Three Different Fluids(Albumin 5%, Normal Saline, Hydroxyethyl Starch 130 kD) on Microcirculation in Severe Sepsis/Septic Shock Patients April 2011 April 2016
NCT01329887 Completed Phase 3 The Effect of Ketanserin on the Microcirculation in Sepsis March 2011 May 2014
NCT01332734 Completed Microcirculatory Changes During Magnesium Sulphate Infusion in Sepsis March 2010 January 2011
NCT01337934 Completed Phase 3 Lactated Ringer Versus Albumin in Early Sepsis Therapy October 2013 December 2017
NCT01352182 Completed Phase 1/Phase 2 Pharmacokinetic and Biomarker Study of Pioglitazone in Adolescents With Severe Sepsis and Septic Shock October 2011 January 2017
NCT01378169 Completed SIRS and Bacterial Sepsis Discrimination by Biomarkers in ICU January 1, 2011 June 1, 2013
NCT01392508 Completed IMproved PREdiction of Severe Sepsis in the Emergency Department March 2011 September 2015
NCT01393782 Completed Phase 1 Intravenous AII for the Treatment of Severe Hypotension in High Output Shock: A Pilot Study July 2011 January 2014
NCT01411670 Completed Phase 2 Administration of Human Protein C Concentrates in Patients With Sepsis and Septic Shock. January 2011 April 2015
NCT01415180 Completed Life After Pediatric Sepsis Evaluation June 1, 2013 June 1, 2018
NCT01434121 Completed Phase 1/Phase 2 Ascorbic Acid (Vitamin C) Infusion in Human Sepsis May 2010 September 2012
NCT01443494 Completed N/A High MAP in Septic Shock With Hypertension June 2011 June 2012
NCT01448109 Completed Phase 4 ADjunctive coRticosteroid trEatment iN criticAlly ilL Patients With Septic Shock June 13, 2012 November 20, 2017
NCT01473498 Completed N/A Personalized Mean Arterial Pressure Management on Renal Function During Septic Shock January 2013 November 2015
NCT01485315 Completed Phase 3 Transfusion-requirements in Septic Shock Trial November 2011 April 2014
NCT01517815 Completed N/A Pharmacokinetic of Doripenem and Piperacillin/Tazobactam in More Than 120 kg Critically Ill Patients February 2012 June 2013
NCT01523717 Completed Procalcitonin Monitoring Sepsis Study December 2011 March 2014
NCT01526382 Completed Phase 1/Phase 2 Use of PiCCO System in Critically Ill Patients With Septic Shock and Acute Respiratory Distress Syndrome January 2012 June 2014
NCT01585909 Completed N/A Evaluation of Intestinal Brush Border Enzyme Function in Critically Ill Patients July 2011 September 2015
NCT01604551 Completed Membrane Shedding During Septic Shock May 2003 December 2011
NCT01611753 Completed N/A Red Blood Cell Transfusion Improves Perfusion Parameters in Septic Shock Patients With Hypoperfusion April 2004 August 2008
NCT01612676 Completed Phase 2 Investigating FE 202158 as Potential Primary Treatment in Patients With Early Septic Shock June 2012 November 2013
NCT01632059 Completed Examination of ADMA Serum Level and DDAH II February 2012 April 2017
NCT01648036 Completed Phase 2 Heparin Anticoagulation to Improve Outcomes in Septic Shock: The HALO Pilot July 2012 February 2014
NCT01649921 Completed Phase 3 The Effects of Interferon-gamma on Sepsis-induced Immunoparalysis November 2012 December 2016
NCT01665092 Completed Phase 2 Rapid Administration of Carnitine in sEpsis January 2013 March 2019
NCT01718613 Completed Phase 3 Vasopressin Versus Norepinephrine for the Management of Septic Shock in Cancer Patients November 2012 May 2018
NCT01775020 Completed Early Phase 1 Dose-response Study of Arginine Supplementation in Severe Sepsis October 2003 May 2012
NCT01790620 Completed N/A Impact of CVVHD With Adsorption Capacity Membranes in Septic Acute Kidney Injury May 2013 October 2017
NCT01806428 Completed Activated Protein C and Microcirculation July 2009 August 2011
NCT01827007 Completed N/A Assessment of Fluid Responsiveness by Elevation of PEEP in Patients With Septic Shock January 2008 February 2013
NCT01836302 Completed Septic Shock and Delirium Because of rSO2 Abnormalities in Intensive Care Unit Patients (The SAD BRAIN Study) August 2012 December 2013
NCT01867905 Completed Antibiotic Administration and Blood Culture Positivity in Severe Sepsis and Septic Shock March 1, 2014 April 10, 2019
NCT01919138 Completed Outcomes of Severe Sepsis Patients in Surgical Intensive Care Units July 2013 June 2014
NCT01929772 Completed German Lactat Clearance in Severe Sepsis September 2012 April 2015
NCT01943747 Completed International Multicentre Prevalence Study on Sepsis November 2013 January 2014
NCT01945983 Completed N/A Early Use of Norepinephrine in Septic Shock Resuscitation October 3, 2013 August 2017
NCT01947127 Completed Venous Lactate in Progression to Overt Septic Shock and Mortality in Non-elderly Sepsis Patients in Emergency Department March 2013 January 2015
NCT01972828 Completed N/A Early Haemodynamic Optimization Using Preload Dependence During Septic Shock = EHOSS-1 July 2007
NCT01973907 Completed Phase 3 Pilot Study for the SQUEEZE Trial January 2014 June 2016
NCT01988428 Completed N/A Prehospital Antibiotics Against Sepsis Trial June 2014 June 2017
NCT02025127 Completed N/A A Randomized Controlled Study of Enteral Nutrition in Septic Shock January 2014 January 2018
NCT02025660 Completed Phase 2/Phase 3 Efficacy of Mw Vaccine in Treatment of Severe Sepsis August 2013 March 2014
NCT02034240 Completed Neutrophil Gelatinase Associated Lipocalin (NGAL) in Urine: Can This Prove to be a Biomarker for Acute Kidney Injury in Patients With Sepsis? January 2014 April 2015
NCT02041663 Completed N/A Septic cArdiac Deficiency and MenIngococcal seveRe Sepsis March 5, 2012 July 11, 2018
NCT02044575 Completed Clock Genes in Patients With Refractory Septic Shock (SeptiClock) - Pilot Study April 2014 March 31, 2019
NCT02050893 Completed Phase 1/Phase 2 The Effect of Midazolam on Fluid Responsiveness in Septic Patients May 2012 April 2013
NCT02053675 Completed N/A Hemodynamic Effects of Vasopressin in Early Septic Shock Stage May 2008
NCT02079402 Completed Phase 4 Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care September 2014 November 2015
NCT02085291 Completed Phase 4 Effect of Different Strategies for Titrating a High MAP on Microcirculation March 2014 September 2017
NCT02116413 Completed Does the Time Between the End of Vascular Filling and Evaluation of Its Effectiveness Modify Fluid Challenge Results in Septic Shock? May 2014 January 2016
NCT02174081 Completed ARDS Prediction Score in Critically Ill Patients in China March 2014 June 2016
NCT02180009 Completed Dynamic Changes of Tim-3 on Monocytes and Soluble Tim-3 in Patients With Sepsis December 2013 December 2015
NCT02186522 Completed Immune Failure in Critical Therapy (INFECT) Study July 2014 January 2016
NCT02188888 Completed Echocardiographic and Arterial Pressure Waveform Changes After Reducing Heart Rate With Esmolol in Septic Shock Patients December 2013 June 2014
NCT02204852 Completed Phase 2 Co-administration of Iloprost and Eptifibatide in Septic Shock Patients September 2014 August 2016
NCT02246595 Completed Phase 2 Studying Complement Inhibition in Early, Newly Developing Septic Organ Dysfunction April 2014 December 2015
NCT02266589 Completed Phase 3 Stress Doses of Hydrocortisone on Coagulation Dysfunction in Patients With Septic Shock November 2011 October 2013
NCT02270281 Completed Phase 4 Dexmedetomidine on Microcirculation in Septic Shock December 2014 May 2017
NCT02288975 Completed Adsorbtion of Cytokines Early in Septic Shock: the ACESS Study October 2014 December 2017
NCT02306928 Completed PK Analysis of Piperacillin in Septic Shock Patients September 2014 January 2015
NCT02346331 Completed N/A Epidemiology, Acute Management, and Outcomes of Patients With Sepsis Presenting to a Referral Hospital in Western Kenya January 2015 September 2016
NCT02354742 Completed N/A Echo vs. EGDT in Severe Sepsis and Septic Shock December 2014 October 2017
NCT02361528 Completed Phase 3 GM-CSF to Decrease ICU Acquired Infections September 14, 2015 June 1, 2018
NCT02370186 Completed The Role of Dysfunctional HDL in Severe Sepsis February 2015 March 12, 2017
NCT02389036 Completed Phase 3 Selective Decontamination of the Digestive Tract in Intensive Care Unit Patients May 1, 2017 April 26, 2023
NCT02393781 Completed Adrenomedullin and Outcome in Severe Sepsis and Septic Shock June 2015 June 2016
NCT02399397 Completed Phase 4 Influence of Age, Sepsis and SLCO1A2 Polymorphisms on Rocuronium Pharmacokinetics February 2014 December 2015
NCT02421484 Completed Phase 1 Cellular Immunotherapy for Septic Shock: A Phase I Trial May 2015 October 30, 2018
NCT02430142 Completed Microcirculatory Oxygen Uptake in Sepsis April 2015 August 1, 2017
NCT02442440 Completed Phase 1/Phase 2 Anisodamine Critically Ill SeptIc Shock April 2015 October 1, 2020
NCT02453425 Completed N/A The Effects of Blood Pressure on Renal Function and Oxygenation in Septic Shock May 2011 March 2017
NCT02464371 Completed Interest of Plasma microRNAs May 2015 May 13, 2017
NCT02473718 Completed N/A Fluid Balance in the ICU - Interventions to Minimize Fluids in Patients With Septic Shock January 2014 January 2015
NCT02519699 Completed Phase 4 Microcirculation After MAP Increase in Septic Shock Patients With Previous Hypertension March 2013 January 2017
NCT02533011 Completed Evaluation of the Heparin Binding Protein Levels in Sepsis July 2015 July 2017
NCT02558166 Completed Renal Resistive Index in Patients With Shock August 2015 February 2016
NCT02566460 Completed N/A The Effect of Lactate Clearance Oriented Haemodynamic Therapy on the Outcome of Patients With Septic Shock January 2013
NCT02580240 Completed N/A Initiation of Hydrocortisone for the Treatment of Septic Shock September 2015 December 2016
NCT02600312 Completed N/A Comparing Cytokines, Toxins Adsorbing oXiris Filter to ST150 Filter During CRRT in Patients With Septic Shock October 2015 January 2018
NCT02635854 Completed N/A Study of Platelet Activation in Septic Shock Patients March 2016 January 5, 2017
NCT02638545 Completed Phase 3 Hemodynamic Effects of Dexmedetomidine in Septic Shock September 2015 February 2017
NCT02638779 Completed N/A REAnimation Low Immune Status Markers December 11, 2015 June 27, 2018
NCT02647554 Completed Phase 4 Ulinastatin Treatment in Adult Patients With Sepsis and Septic Shock in China December 2016 August 1, 2021
NCT02655133 Completed Phase 2 Effects on Microcirculation of IgGAM in Severe Septic/Septic Shock Patients. January 2016 January 1, 2018
NCT02681653 Completed N/A Study the Impact of Statins in Septic Shock January 2012 January 2015
NCT02734550 Completed N/A (1,3)-β-D-glucan Based Diagnosis of Invasive Candida Infection in Sepsis September 12, 2016 September 17, 2019
NCT02748382 Completed Phase 2/Phase 3 Fluids in Sepsis and Septic Shock August 18, 2016 August 19, 2017
NCT02750683 Completed Norepinephrine Exerts an Inotropic Effect at the Early Phase of Human Septic Shock October 2014 January 2016
NCT02766946 Completed N/A Diaphragmatic Atrophy Related to Mechanical Ventilation June 24, 2013 December 22, 2015
NCT02768740 Completed Phase 4 Hydrocortisone 50 mg Every 6 Hours Compared to Hydrocortisone 300 mg Per Day in Treatment of Septic Shock. April 2008 September 2014
NCT02780466 Completed Observational Study on Intubation in Septic Shock May 2016 April 2018
NCT02805049 Completed Phase 4 Pharmacokinetic Study on Echinocandins for Patients With Septic Shock Following Secondary Peritonitis January 28, 2017 June 23, 2018
NCT02820675 Completed N/A Quality Improvement in Infection COntrol and Sepsis Management in MOdel Regions August 2015 July 2019
NCT02835157 Completed N/A Balanced Crystalloid vs. Saline in Children With Septic Shock April 1, 2017 January 15, 2020
NCT02841241 Completed Phase 2 Esmolol Infusion for Patients With Septic Shock and Persistent Tachycardia April 2016 March 2017
NCT02856191 Completed N/A Study on the Frequency of de Novo Atrial Fibrillation in Septic Shock in Medical Intensive Care January 2011
NCT02876341 Completed Effects of Chronic Antihypertensive Therapy on Clinical Outcomes in Septic Shock August 2016 March 31, 2017
NCT02884011 Completed Evaluating the Effect of Chronic Antihypertensive Therapy on Vasopressor Dosing in Septic Shock August 2016 March 31, 2017
NCT02885168 Completed Phase 4 Modulation of Vasoreactivity in Septic Shock: Impact of Recombinant Protein C February 2008 April 2009
NCT02918214 Completed Prognostic Assessment of Diastolic and Systolic Left Ventricular Function in Septic Shock January 2017 October 2019
NCT02934997 Completed The Role of Dysfunctional HDL in Sepsis November 1, 2016 May 3, 2019
NCT02961166 Completed Immunglobulin M Enriched Intra Venous Immunoglobulin (IVIG) Therapy in Adult Respiratory Distress Syndrom (ARDS) Patients January 2012 May 2016
NCT03014063 Completed Vasopressin Plasma Concentrations in Patients Receiving Exogenous Vasopressin Infusion for Septic Shock November 2016 June 2017
NCT03015454 Completed N/A An Algorithm Driven Sepsis Prediction Biomarker December 2016
NCT03020407 Completed N/A The Randomized Controlled Trial of Inferior Vena Cava Ultrasound-guided Fluid Management in Septic Shock Resuscitation January 18, 2017 July 31, 2020
NCT03029169 Completed Phase 4 Propafenone Versus Amiodarone in Septic Shock October 23, 2017 August 1, 2022
NCT03034174 Completed Pharmacokinetics of High-dose Tigecycline in Critically Ill Patients January 15, 2017 October 10, 2018
NCT03037281 Completed Release of Nociceptin From Granulocytes in Sepsis April 7, 2016 June 30, 2019
NCT03055455 Completed Neuroimaging and Neuromonitoring in Critically Ill Children With Sepsis February 1, 2017 September 27, 2019
NCT03077672 Completed Mitochondrial DNA as a Biomarker of Sepsis Severity February 10, 2017 December 22, 2020
NCT03078712 Completed N/A Early Goal Directed Therapy Using a Physiological Holistic View. The ANDROMEDA-SHOCK Study March 1, 2017 June 30, 2018
NCT03080038 Completed N/A SQUEEZE Trial: A Trial to Determine Whether Septic Shock Reversal is Quicker in Pediatric Patients Randomized to an Early Goal Directed Fluid Sparing Strategy vs. Usual Care March 6, 2017 December 31, 2021
NCT03085459 Completed Effects of Nursing Staff on Empiric Antibiotic in Septic Shock January 12, 2015 February 29, 2016
NCT03085758 Completed Phase 2 Treatment of Patients With Early Septic Shock and Bio-Adrenomedullin(ADM) Concentration > 70 pg/ml With ADRECIZUMAB December 12, 2017 December 20, 2019
NCT03092245 Completed Phase 2 Vasculopathic Injury and Plasma as Endothelial Rescue in Septic Shock (SHOCK) Trial April 18, 2017 April 17, 2019
NCT03104140 Completed Phase 3 Ketamine Versus Low Dose Thiopental for Induction of Anesthesia in Septic Shock April 12, 2017 April 15, 2018
NCT03104933 Completed Proadrenomedullin and Copeptin in Patients With Septic Shock July 1, 2016 March 11, 2021
NCT03120637 Completed Phase 4 Evaluating in Cirrhotics With Refractory Vasoplegia the Effect of Methylene Blue January 1, 2017 January 10, 2018
NCT03136081 Completed Candida Host Defense Response After Septic Shock in the Critically Ill June 2014 May 2015
NCT03137446 Completed N/A Restrictive Intravenous Fluids Trial in Sepsis April 20, 2017 March 30, 2018
NCT03201575 Completed N/A REmote Ischemic COnditioning in Septic Shock November 28, 2017 August 12, 2019
NCT03226366 Completed Effect of Emergency Department Care Reorganization on Door-to-antibiotic Times for Sepsis (LDS SWARM) May 16, 2015 April 11, 2020
NCT03235193 Completed N/A Predictive algoRithm for EValuation and Intervention in SEpsis July 1, 2017 August 30, 2017
NCT03246893 Completed N/A Efficacy of HFNC Versus NIV for Prevent Reintubation in Sepsis Patients May 1, 2017 October 31, 2019
NCT03249246 Completed Epidemiology of Sepsis in Turkish ICUs. January 27, 2016 February 27, 2016
NCT03251170 Completed Phase 4 Ketamine Versus Fentanyl for Induction of Anesthesia in Septic Shock January 25, 2018 December 30, 2019
NCT03258619 Completed Natriuresis as a Predictor of the Haemodynamic Response to Steroid Replacement Therapy in Patients in Septic Shock February 27, 2017 November 15, 2017
NCT03270774 Completed Central Venous Catheter Colonisation Among Critically Ill Patients in Intensive Care Units April 19, 2016 April 19, 2017
NCT03277677 Completed Phase 3 The Effect of Fluid Resuscitation With 0.9% Sodium Chloride Versus Balanced Crystalloid Solution on Renal Function of Sepsis Patients July 1, 2017 March 1, 2021
NCT03292120 Completed N/A Venous to Arterial Carbon Dioxide Difference (P₍ᵥ-ₐ₎CO₂): Predictor of Septic Patient Prognosis Depending on the ScvO₂ June 2016 May 2019
NCT03297203 Completed N/A Innate Lymphoid Cells in Septic Shock August 2, 2017 August 9, 2023
NCT03308214 Completed The Analysis of Factors Influencing the Vd of Imipenem in Septic Shock Patients March 18, 2018 December 28, 2018
NCT03338569 Completed Phase 2/Phase 3 Vitamin C and Septic Shock December 20, 2017 August 10, 2020
NCT03344627 Completed N/A Clinical Outcome Study of High-dose Meropenem in Sepsis and Septic Shock Patients November 27, 2017 December 31, 2018
NCT03356249 Completed Next-Generation Sequencing Diagnostics of Bacteremia in Sepsis March 1, 2019 September 30, 2021
NCT03388944 Completed N/A PCT Guided Stopping of Antibiotic Therapy in Children With Sepsis October 21, 2019 February 28, 2023
NCT03389555 Completed Phase 2/Phase 3 Ascorbic Acid, Corticosteroids, and Thiamine in Sepsis (ACTS) Trial February 9, 2018 February 28, 2020
NCT03395951 Completed Mean Systemic Filling Pressure Continuous Diuretics Critical Care Patients October 1, 2014 January 31, 2015
NCT03399032 Completed Pharmacokinetics of Caspofungin February 5, 2018 September 3, 2018
NCT03422159 Completed Phase 2 Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in Sepsis. February 5, 2018 August 27, 2019
NCT03426943 Completed N/A Endotoxins and Cytokines Removal During Continuous Hemofiltration With oXiris™ December 21, 2018 June 3, 2022
NCT03434028 Completed Phase 3 Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis March 7, 2018 August 24, 2022
NCT03438097 Completed Survey of Non-resuscitation Fluids in Septic Shock March 1, 2018 August 15, 2018
NCT03452865 Completed Phase 3 Esomeprazole to Reduce Organ Failure in Sepsis January 28, 2020 August 21, 2023
NCT03456180 Completed Changes in Microvascular Perfusion During Blood Purification With Cytosorb® in Septic Shock December 9, 2016 December 15, 2017
NCT03461900 Completed N/A Guided Fluid-balance Optimization With Mini-fluid chALlenge During Septic Shock June 4, 2019 January 8, 2024
NCT03475667 Completed Comparison of Radial and Femoral Artery Site Invasive Blood Pressure Measurement in Septic Shock Patients April 11, 2018 January 10, 2020
NCT03475732 Completed N/A Pharmacokinetics of XueBiJing in Patients With Sepsis March 18, 2018 December 31, 2019
NCT03480555 Completed N/A Replacing Protein Via Enteral Nutrition in a Stepwise Approach in Critically Ill Patients May 16, 2018 September 10, 2019
NCT03572751 Completed Suitability of Unobtrusive Bed Monitoring and Wrist-worn Heart Rate Monitor for Patient Monitoring April 9, 2018 December 31, 2018
NCT03592277 Completed Phase 2 Vitamin C & Thiamine to Treat Sepsis and Septic Shock September 14, 2018 February 22, 2021
NCT03655626 Completed N/A Implementation and Evaluations of Sepsis Watch November 5, 2018 July 5, 2019
NCT03700346 Completed N/A Muscle Lactate and Lactate to Pyruvate Ratio Clearance in Septic Shock Patients January 1, 2018 December 31, 2018
NCT03708796 Completed DIAGNOSis of Infection in Emergency Department April 9, 2018 September 1, 2018
NCT03710187 Completed Phase 2 HCT+F vs. HCT Alone in Critically Ill Medical Septic Shock Patients November 5, 2018 September 27, 2019
NCT03716310 Completed Platelet Reactivity in Septic Shock April 1, 2017 August 30, 2018
NCT03748537 Completed N/A Mitochondrial Function in Septic Patients January 1, 2017 December 31, 2019
NCT03756220 Completed Phase 2 Ascorbic Acid and Thiamine Effect in Septic Shock December 1, 2018 April 14, 2020
NCT03765489 Completed N/A Electrical Muscle Stimulation in the Development of Acquired Weakness in Patients With Severe Sepsis and Septic Shock November 18, 2016 June 21, 2018
NCT03799159 Completed Renal Arterial Resistive Index Versus Novel Biomarkers for Early Prediction of Sepsis Associated-acute Kidney Injury May 15, 2019 February 28, 2021
NCT03805321 Completed The Validity of Peripheral Perfusion Index to Predict Fluid Responsiveness January 27, 2019 July 1, 2019
NCT03821714 Completed N/A Effects of Glucocorticoid Combined With Vitamin C and Vitamin B1 on Microcirculation in Severe Septic Shock February 1, 2019 January 30, 2020
NCT03841162 Completed Fast Assay for Pathogen Identification and Characterization February 12, 2019 April 17, 2020
NCT03844984 Completed Phase 3 Lidocaine-Ketamine Versus Ketamine for Induction of Anesthesia in Septic Shock Patients February 20, 2019 September 20, 2019
NCT03861325 Completed Acute Intestinal Failure in Critically Ill Patients and Microbial Translocation April 2, 2019 September 9, 2020
NCT03872011 Completed Phase 3 Vitamin C, Thiamine and Hydrocortisone for the Treatment of Septic Shock February 19, 2019 September 20, 2021
NCT03891342 Completed N/A Effect of Fluid Challenge on Glycocalyx February 2016 August 2018
NCT03911817 Completed Phase 4 Impact of Midodrine Administration on the Clinical Outcome of Septic Shock Patients November 15, 2017 July 30, 2019
NCT03913468 Completed Outcomes of Septic Shock Patients Treated With a Metabolic Resuscitation Bundle Consisting of Intravenous Hydrocortisone, Ascorbic Acid and Thiamine. January 1, 2019 December 1, 2019
NCT03926533 Completed N/A TelePORT Pilot Study November 1, 2019 February 28, 2023
NCT03931967 Completed Proadrenomedullin and Microcirculation in Monitoring Organ Dysfunction in Patient With Infection November 8, 2018 June 4, 2019
NCT03946839 Completed Functional Magnetic Resonance Imaging (fMRI) of Brain in ICU Survivors With Cognitive Impairment June 1, 2020 January 20, 2024
NCT03974386 Completed N/A Effects of Endotoxin Absorption and Cytokine Removal Hemofilter on Severe Septic Shock July 1, 2019 August 20, 2020
NCT03987048 Completed Cirrhotic Patients With Septic Shock April 2014 April 2015
NCT03989609 Completed Phase 2 Dexmedetomidine in Modifying Immune Paralysis In Patient With Septic Shock June 20, 2019 August 20, 2021
NCT03996720 Completed Early Identification and Effective Management of Pediatric Sepsis October 1, 2018 September 30, 2021
NCT04080453 Completed Pro-inflammatory Role of Blood Platelets in Critically Ill Patients With Septic Shock. November 9, 2020 April 25, 2024
NCT04089098 Completed VOLume and Vasopressor Therapy in Patients With Hemodynamic instAbility September 1, 2019 September 30, 2021
NCT04103203 Completed N/A Fast Assay for Pathogen Identification - Quasi-Experimental Intervention Study July 1, 2019 April 30, 2020
NCT04111822 Completed Phase 3 Pilot Study on the Use of Hydrocortisone, Vitamin c and Tiamine in Patient With Sepsis and Septic Shock October 31, 2018 October 31, 2020
NCT04123444 Completed Phase 2/Phase 3 Infusion of Prostacyclin (Iloprost) vs Placebo for 72-hours in Patients With Septic Shock Suffering From Organ Failure October 30, 2019 June 28, 2022
NCT04153578 Completed Time to Lose the Weight? Comparison of Weight-based and Non-weight-based Vasopressors for Septic Shock November 4, 2019 June 22, 2020
NCT04197115 Completed Phase 3 Vitamin C, Thiamine, Cyanocobalamine, Pyridoxine and Hydrocortisone in Sepsis September 1, 2019 September 30, 2020
NCT04227652 Completed N/A Control of Fever in Septic Patients September 3, 2013 March 31, 2019
NCT04231994 Completed Phase 2 Therapeutic Plasmaexchange in Early Septic Shock June 1, 2018 August 31, 2020
NCT04292431 Completed Leukocyte MOrphology and CORticosteroids Response in SEPtic Patients (MOCORSEP) November 1, 2019 December 30, 2020
NCT04302584 Completed N/A Norepinephrine / Vasopressin Combination for Resuscitation in Septic Shock January 1, 2018 January 6, 2019
NCT04346693 Completed Phase 3 An Open Randomized Study of Dalargin Efectiveness in Combination With Leitragin Drug in Patients With Severe and Critical Manifestations of SARS-COVID-19 April 8, 2020 November 20, 2020
NCT04409561 Completed Reference Range for abioSCOPE® Device With the PSP Assay in a Generally Healthy Adult Population November 15, 2021 January 15, 2022
NCT04446871 Completed Phase 2/Phase 3 Methylene Blue in Early Septic Shock March 17, 2017 January 25, 2021
NCT04449081 Completed Knowledge, Attitude and Practice of Dental Students About COVID-19 April 25, 2020 June 20, 2020
NCT04457739 Completed Assessment of Preload Responsiveness in ARDS Patients During Prone Position January 8, 2019 December 31, 2021
NCT04459572 Completed N/A As an Early Indicator Biomarker of Prognosis and Mortality in Children With Sepsis and Septic Shock: suPAR March 27, 2019 June 25, 2020
NCT04470856 Completed N/A Carotid Doppler and EEOT for Fluid Responsiveness Prediction January 1, 2019 December 31, 2020
NCT04492280 Completed Phase 4 Evaluation of the Role of Hydrocortisone Either Alone or Combined With Fludrocortisone in the Outcome of Septic Shock in Adults September 1, 2018 September 1, 2019
NCT04494789 Completed Phase 2 Fludrocortisone Dose Response Relationship in Septic Shock - FluDReSS February 11, 2021 June 30, 2023
NCT04508946 Completed Phase 3 Triple Therapy in Septic Shock Patients August 1, 2019 November 9, 2020
NCT04530045 Completed Target Attainment of TDM-guided Infusion of Piperacillin/Tazobactam and Cefepim in Critically Ill Patients May 2, 2018 November 2, 2019
NCT04553367 Completed Phase 1/Phase 2 Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ventilation July 2, 2020 December 1, 2021
NCT04558359 Completed Phase 4 Renin and Renal Biomarker Response to Angiotensin II October 19, 2020 July 30, 2023
NCT04567199 Completed Influence of Cytosorb on Amount of Catecholamine and Mortality in Sepsis December 1, 2018 December 1, 2020
NCT04567433 Completed Days Alive and Out of Hospital for Patients With Sepsis September 14, 2020 February 23, 2024
NCT04580563 Completed N/A Study Assessing Efficacy of Plasmatherapy in Septic Shock-induced Coagulopathy: Feasibility Study October 22, 2020 January 3, 2023
NCT04644926 Completed Phase 1/Phase 2 The Effect of Remote Ischemic Conditioning on the Microcirculation in Sepsis February 1, 2018 September 1, 2020
NCT04665089 Completed N/A Erythromycin in Septic Patients: Immunomodulatory Role and Clinical Impact January 1, 2022 April 30, 2023
NCT04683094 Completed Comparative Study for the Validity of Various Severity Scoring System April 1, 2020 December 30, 2021
NCT04747795 Completed Phase 3 Early Administration of Vitamin C in Patients With Sepsis or Septic Shock in Emergency Departments June 1, 2021 November 15, 2023
NCT04773717 Completed N/A The Effect of High Dose Parenteral Ascorbic Acid On Microcirculation In Sepsis January 1, 2019 January 31, 2021
NCT04827407 Completed N/A Lipopolysaccharide Adsorption at Septic Shock March 23, 2021 August 30, 2022
NCT04834921 Completed N/A MCO Membrane Efficiency in Septic Shock Patients December 31, 2017 January 31, 2021
NCT04884854 Completed Efferon LPS Hemoperfusion for Treatment of Patients With Septic Shock September 13, 2019 October 12, 2020
NCT04901338 Completed Cytokine Hemoadsorption in ECMO Patients June 1, 2017 January 31, 2021
NCT04910893 Completed N/A Cytokine Adsorption in Severe, Refractory Septic Shock November 27, 2014 December 31, 2018
NCT04947904 Completed N/A OPTImized Restrictive Strategy Targeting Non-Resuscitative FLUIDs in Septic Shock: Pilot Study. September 20, 2021 February 25, 2023
NCT04948372 Completed N/A Effects of Terlipressin on Renal Perfusion in Patients With Septic Shock September 1, 2019 June 28, 2020
NCT04952714 Completed RRT With a Cytokine Absorption Filter (oXiris ®) in Patients With Septic Shock September 1, 2021 November 10, 2023
NCT04977011 Completed N/A Effectiveness of Music Intervention on Anxiety and Physiological Responses in Critical Ill Patient January 2, 2019 July 30, 2019
NCT04991376 Completed Specific miRNAs in Sepsis and Nephrotoxic Antibiotic Treatment May 2, 2019 December 1, 2022
NCT05060679 Completed Presepsin:Gelsolin Ratio in Sepsis-related Organ Dysfunction January 1, 2018 February 29, 2020
NCT05065333 Completed N/A Implementation Trial of Predictive Modeling to Enhance Diagnosis and Improve Treatment in Pediatric Septic Shock March 16, 2022 March 31, 2023
NCT05066464 Completed Fluid Resuscitation for Suspected Sepsis in Paediatric Emergency Departments November 29, 2021 April 28, 2022
NCT05094856 Completed Effects of Fluid Therapy on Peripheral TIssse Perfusion During Sepsis/Septic Shock February 23, 2022 March 16, 2023
NCT05140213 Completed A STUDY BEFORE/AFTER THE IMPLEMENTATION OF AN ANTI-INFECTIOUS PRESCRIPTION AID December 12, 2020 August 30, 2021
NCT05141071 Completed Phase 2 Effect of Ivabradine on Microcirculation and Cardiac Output in Septic Shock Patients November 25, 2021 June 5, 2022
NCT05172479 Completed Prognostic Accuracy of qSOFA, SIRS, and EWSs for In-hospital Mortality in Emergency Department December 12, 2021 September 11, 2023
NCT05208112 Completed Phase 1 Intravenously Administered M6229 in Critically Ill Sepsis Patients April 5, 2022 September 28, 2023
NCT05270798 Completed Phase 2 Thyroid Hormone Supplementation in Patients With Septic Shock May 1, 2022 August 1, 2023
NCT05271032 Completed PiCCO ASSESSMENT IN PATIENTS WITH SEPTIC SHOCK March 1, 2018 May 1, 2019
NCT05283083 Completed Phase 2 Decatecholaminisation of Septic Shock With Dexmedetomidine and In-hospital Mortality March 25, 2022 March 1, 2023
NCT05283317 Completed Phase 1/Phase 2 Effect of Mesenchymal Stromal Cells on Sepsis and Septic Shock March 11, 2018 November 13, 2019
NCT05310812 Completed Evaluation of Candidate Biomarkers to Predict Disease Severity and Acute Kidney Injury in Sepsis Patients December 1, 2021 November 29, 2022
NCT05355961 Completed Effect of Norepinephrine Administration on Ventricular Systolic Function in Septic Shock March 10, 2022 May 20, 2024
NCT05358912 Completed Phase 4 Efficacy of Targeted Abdominal Perfusion Pressure in Septic Shock December 2, 2019 September 21, 2022
NCT05401695 Completed N/A The Role of Blood Purification by Hemoadsorption as Adjunctive Treatment in Children With Septic Shock July 1, 2021 April 30, 2022
NCT05496816 Completed Coagulation Disturbances in COVID-19 Septic Patients January 1, 2021 December 31, 2021
NCT05578534 Completed CO2 Gap Changes in Septic Shock in Relation to Cardiac Output December 1, 2020 October 1, 2022
NCT05629780 Completed N/A Temporal Changes of Lactate in CLASSIC Patients September 29, 2022 June 14, 2023
NCT05658588 Completed N/A Hemodynamic Impact of Cytosorb and CKRT in Children With Septic Shock September 1, 2019 October 1, 2021
NCT05840718 Completed Supplemental Thiamine in Septic Shock: A Before-after Study September 1, 2023 December 31, 2023
NCT05957302 Completed N/A Hemodynamic Effects of Bolus of Ketamine Versus Fentanyl in Patients With Septic Shock August 1, 2023 December 15, 2023
NCT05968287 Completed Can Measurement of Neutrophil-derived ROS Production be a Novel Biomarker of Sepsis? June 28, 2022 January 31, 2023
NCT05972980 Completed Ventilator-Associated Pneumonia in Critically Ill COVID-19 vs. Non-COVID-19 Patients January 1, 2016 December 31, 2022
NCT05991778 Completed Bioelectrical Impedance in Monitoring Hyperhydration and Polyneuromyopathy in Critically Ill Patients March 1, 2021 May 31, 2022
NCT05999682 Completed Phase 1/Phase 2 Improvement of Organ Function by Apigenin in Elderly Patients With Sepsis September 1, 2023 January 5, 2024
NCT06008067 Completed The Prognostic Role of Tricuspid Annular Plane Systolic Excursion in Critically Ill Patients With Septic Shock April 1, 2023 July 1, 2023
NCT06072222 Completed Phase 1/Phase 2 Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ventilation July 2, 2020 December 1, 2021
NCT06072248 Completed Phase 1/Phase 2 Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ventilation July 2, 2020 December 1, 2021
NCT06076980 Completed Phase 4 Heamodynamic Effects of Paracetamol in Septic Shock Patients November 1, 2020 January 24, 2023
NCT06121115 Completed Norepinephrine Administration Through a Midline Catheter in an Intermediate Care Unit October 3, 2023 March 1, 2024
NCT06144463 Completed N/A Lung Ultrasound-guided Fluid Resuscitation in Neonatal Septic Shock January 1, 2022 June 30, 2023
NCT06152458 Completed Phase 4 Blessing or Curse? Combined Vitamin Therapy in Non Viral Septic Shock. January 1, 2019 March 1, 2020
NCT06169475 Completed N/A Effect of Dexmedetomidine vs Esmolol or Placebo on Cerebral Hemodynamics in Septic Shock November 1, 2020 November 1, 2023
NCT06180265 Completed N/A The Diagnostic and Prognostic Value of Presepsin in Sepsis February 1, 2020 July 19, 2023
NCT06224881 Completed Phase 4 Vitamin C Deficiency in Septic Shock December 1, 2021 January 31, 2023
NCT06242626 Completed Euthyroid Sick Syndrome in Septic Shock October 1, 2022 August 30, 2023
NCT06354452 Completed Effect of Statin Therapy on Sepsis-related Mortality in Intensive Care Unit Patients January 1, 2018 January 31, 2020
NCT06368336 Completed Health Related Quality of Life After Intensive Care for Sepsis, a National Cohort Study. January 1, 2008 December 31, 2022
NCT06404424 Completed Combined Hemoperfusion and Therapeutic Plasma Exchange for Treatment of Patients With Septic Shock May 1, 2022 March 1, 2024
NCT06461390 Completed Phase 2/Phase 3 The Effect of Fluid Loading With Early Norepinephrine Administration on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in Pediatric Septic Shock March 25, 2024 May 31, 2024
NCT05602584 Enrolling by invitation Effect of Immunophenotype on Prognosis of Sepsis October 1, 2021 December 1, 2023
NCT05900284 Enrolling by invitation Phase 2 Safety and Feasibility of Metformin for Sepsis Induced AKI November 8, 2023 December 21, 2026
NCT06217562 Enrolling by invitation Phase 4 Vasopressin for Septic Shock Pragmatic Trial February 1, 2024 December 2027
NCT04352985 No longer available Evaluating the Use of Polymyxin B Cartridge Hemoperfusion for Patients With Septic Shock and COVID 19
NCT05444621 Not yet recruiting Carotid Ultrasounds Measurements in Septic Shock July 1, 2022 October 31, 2024
NCT05193682 Not yet recruiting Right Ventricular Dysfunction in Septic Shock Patients in ICU October 2022 March 2023
NCT05389176 Not yet recruiting N/A Effects of Heart Control at Different Stages in Patients of Septic Shock With Tachycardia July 1, 2022 June 30, 2024
NCT06330610 Not yet recruiting N/A Evaluation of the Efficiency of Intermittent Enteral Nutrition on Multi-organ Failure From Patients With Mechanical Ventilation in Intensive Care Unit May 1, 2024 August 1, 2027
NCT06118775 Not yet recruiting N/A Evaluating Dynamic Arterial Elastance in Septic Shock Patients. July 1, 2024 July 1, 2026
NCT06302998 Not yet recruiting Phase 2 Dexmedetomidine and Vasopressin in Septic Shock June 2024 January 2026
NCT06072430 Not yet recruiting Phase 3 A Phase III, Open Label, Randomized, Controlled Study of VBI-S in the Treatment of Hypovolemia in Patients With Septic Shock (VBI-S-02) July 2024 July 2025
NCT06258291 Not yet recruiting N/A First in Human Trial to Assess the Safety of HemoSystem REBOOT in Patients With Sepsis-induced Immunosuppression October 15, 2024 October 30, 2025
NCT06013033 Not yet recruiting DDX17 Orchestrate Septic Vascular Endothelial Pyroptosis by Controlling Gasdermin D Pore Formation September 1, 2023 December 31, 2025
NCT06394947 Not yet recruiting Fluid Challenge in Intensive Care The FENICE II Study January 1, 2025 December 31, 2025
NCT06234592 Not yet recruiting N/A The Effect of Vasopressor Therapy on Renal Perfusion in Septic Shock January 2024 July 2026
NCT06227702 Not yet recruiting N/A Vexus-guided Fluid Management in Patients With Septic Shock After the Resuscitation Phase February 1, 2024 February 28, 2026
NCT05921825 Not yet recruiting Red Cell Distribution Width and Lactate Albumin Ratio as Prognostic Markers for Mortality in Sepsis and Septic Shock July 1, 2023 January 30, 2024
NCT06156059 Not yet recruiting Phase 4 Oral Bedtime Melatonin in Critically Ill Patients February 1, 2025 April 1, 2026
NCT06464510 Not yet recruiting Phase 3 Norepinephrine and Vasopressin for Rescue Versus Early Vasopressin for Vasopressor Dependent Sepsis July 2024 September 2027
NCT05726825 Not yet recruiting N/A Efficacy of add-on Plasma Exchange as an Adjunctive Strategy Against Septic Shock November 28, 2023 January 31, 2027
NCT05645887 Not yet recruiting Phase 2 Human Albumin Treatment in Adult Septic Shock. A Study Evaluating Immune Response and Organ Failure. November 2023 May 2026
NCT06156072 Not yet recruiting Ultrasound-guided Blood Sampling Drawing for Microbiological Analysis in the Critically Ill April 2024 December 31, 2025
NCT06184659 Not yet recruiting Phase 4 Empirical Meropenem Versus Piperacillin/Tazobactam for Adult Patients With Sepsis August 1, 2024 March 30, 2029
NCT06366854 Not yet recruiting N/A UK ANDROMEDA-Shock-2 RCT May 1, 2024 April 30, 2028
NCT05586282 Not yet recruiting Role of Candidate Proteins in Capillary Leakage During Acute Circulatory Failure November 2022 April 2026
NCT06124092 Not yet recruiting Outcomes of Children After Hospitalization in Intensive Care Unit March 2024 March 2029
NCT05572060 Not yet recruiting N/A Effect of Metformin Use on Mortality in Diabetic and Non Diabetic Patients With Sepsis and Septic Shock. December 1, 2022 January 31, 2025
NCT05525936 Not yet recruiting Echocardiographic Evaluation of RV Injury in the ICU January 1, 2023 July 1, 2023
NCT06446947 Not yet recruiting Identification of Markers of Poor Clinical Prognosis in Sepsis by Epigenetic Analysis July 1, 2024 January 11, 2026
NCT05453565 Not yet recruiting Restricted or Liberal Fluid for Haemodynamic Resuscitation in Sepsis November 2024 November 2025
NCT04013269 Recruiting N/A Adjuvant Therapy With CytoSorb in Refractory Septic Shock January 1, 2020 December 2023
NCT03494959 Recruiting Phase 2 Pentaglobin in CRE and PA Neutropenic Infections December 6, 2019 June 30, 2025
NCT03528213 Recruiting Phase 2/Phase 3 Utility of Sodium Lactate Infusion During Septic Shock October 4, 2019 November 2023
NCT03649633 Recruiting Phase 1/Phase 2 Vitamin C, Steroids, and Thiamine, and Cerebral Autoregulation and Functional Outcome in Septic Shock September 6, 2018 May 2025
NCT05349370 Recruiting N/A Lactate Kinetics in Septic Shock December 28, 2022 December 31, 2024
NCT05383963 Recruiting Evaluation of Parameters Collected From Routine Data for the Diagnosis of Sepsis and Septic Shock and Their Influence on Time to Diagnosis and Patient Outcome July 15, 2022 December 2027
NCT05386199 Recruiting The Role of Serotonin in Intensive Care Patients May 25, 2022 December 31, 2024
NCT03754257 Recruiting N/A Effects of Electrical Stimulation for Preventing Loss of Muscle Mass in Patients With Sepsis October 1, 2018 July 31, 2024
NCT06178822 Recruiting Towards Novel BIOmarkers to Diagnose SEPsis on the Emergency Room October 25, 2022 October 1, 2026
NCT03783091 Recruiting Phase 2 A Trial of Vitamin B12 in Septic Shock August 5, 2019 December 2025
NCT05402553 Recruiting Phase 1/Phase 2 The Efficacy of Adjunctive Use of Ondansetron in Patients With Sepsis and Septic Shock April 24, 2022 June 2023
NCT05428423 Recruiting Reliability of PVI Changes During Tidal Volume Challenge in ICU Patients June 6, 2022 November 2022
NCT05491941 Recruiting N/A Assessment for Implementation Methods in Sepsis July 15, 2022 July 15, 2027
NCT05506319 Recruiting N/A Hypotension in the Weaning From Vasopressor Drugs April 4, 2022 October 2023
NCT03892174 Recruiting N/A Cytokine REmoval in CRitically Ill pAtients Requiring Surgical Therapy for Infective Endocarditis (RECReATE) November 14, 2019 December 1, 2024
NCT03901807 Recruiting N/A Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study October 17, 2019 September 30, 2025
NCT05552521 Recruiting Diastolic Dysfunction in Septic Shock and Cardiomyopathy Genetic Variants September 20, 2022 December 31, 2023
NCT03920982 Recruiting N/A Prognostic Value Serum Concentration of Indoxyl Sulfate During Acute Kidney Injury in Septic Shock Patients. December 10, 2019 July 2023
NCT05557461 Recruiting Assessment of Fluid Responsiveness in Septic Shock Patients, Can End-tidal co2 Measurement Help? September 20, 2022 March 30, 2023
NCT05565222 Recruiting Phase 3 Piperacillin-tazobactam and Temocillin as Carbapenem-alternatives for the Treatment of Severe Infections Due to Extended-spectrum Beta-lactamase-Producing Gram-negative Enterobacteriaceae in the Intensive Care Unit March 11, 2023 June 2026
NCT03948048 Recruiting Study on the Efficacy and Timing of ECMO Therapy in Children With Refractory Septic Shock August 1, 2020 December 31, 2024
NCT03990467 Recruiting N/A Observed Pharmacokinetic of Piperacillin/Tazobactam Compared to Amikacin in ICU January 28, 2021 January 28, 2023
NCT03992378 Recruiting N/A Neuromodulation to Regulate Inflammation and Autonomic Imbalance in Sepsis October 10, 2019 December 2025
NCT04057872 Recruiting Phase 1 Therapeutic Plasma Exchange in Adult Patients With Severe Sepsis October 21, 2020 December 31, 2024
NCT04067674 Recruiting Septic Shock-induced Immunosuppression October 21, 2019 November 21, 2024
NCT05627817 Recruiting Timing of Preload Responsiveness in Sepsis February 20, 2019 December 2023
NCT04089072 Recruiting Phase 2 Methylene Blue as a Third-line Vasopressor in Septic Shock December 1, 2019 November 1, 2024
NCT05630716 Recruiting N/A Non-Invasive Cardiac Output Monitor (NICOM) for Goal-directed Fluid Resuscitation for Inpatients With Hypotension and/or Septic Shock July 31, 2023 November 30, 2025
NCT05633290 Recruiting CharacterisatiON of carDiac funCTion in Intensive Care Unit Survivors of Sepsis. March 1, 2023 February 2024
NCT01315782 Recruiting Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis December 2016 December 2024
NCT01363635 Recruiting Severe Sepsis/Septic Shock on Admission to the General Surgical ICU June 2011 June 2024
NCT05681052 Recruiting Mottling Score and Central Venous Oxygen Saturation in Septic Shock Patients October 1, 2022 January 21, 2023
NCT04203979 Recruiting Sepsis: From Syndrome to Personalized Care January 6, 2020 December 31, 2026
NCT05694455 Recruiting N/A Micro and Macro Circulation in Sepsis July 1, 2022 December 31, 2024
NCT05707494 Recruiting N/A Lipopolysaccharide Adsorption (Efferon LPS NEO) in Children With Sepsis January 1, 2023 April 30, 2025
NCT04281277 Recruiting N/A Relation Between Mean Arterial Pressure and Renal Resistive Index in the Early Phase of Septic Shock June 6, 2020 March 15, 2026
NCT04288635 Recruiting Impact of Metabolite Supplementation to Restore Mitochondrial Dysfunction During Septic Shock: a Preclinical Study July 9, 2020 August 9, 2024
NCT05725837 Recruiting Phase 2 Effects of Paroxetine on Cardiovascular Function in Septic Patients June 10, 2023 July 15, 2024
NCT04306419 Recruiting Observational Trial on Cytokine Adsorption in Sepsis November 15, 2020 May 31, 2024
NCT04316884 Recruiting Mechanisms for Organ Dysfunction in Covid-19 March 12, 2020 December 31, 2026
NCT04339868 Recruiting Phase 2 Terlipressin for Refractory Septic Shock April 3, 2020 July 31, 2025
NCT05731349 Recruiting N/A Impact of Early Sepsis Care Guided by the National Early Warning Score 2 in the Emergency Department April 1, 2023 May 31, 2025
NCT05761522 Recruiting Cardiovascular Effects of Norepinephrine April 21, 2023 June 21, 2024
NCT05778838 Recruiting Phase 4 Midodrine Effect on the Mortality Rates in Septic Shock Patients April 1, 2023 April 30, 2024
NCT05787184 Recruiting Sepsis Early EvaluatioN Through Rapid Ultrasound and veNous Gas Analysis January 1, 2023 June 1, 2024
NCT05818826 Recruiting Phase 2 Early Versus Conventional Cessation of Hydrocortisone in Septic Shock July 5, 2023 May 2025
NCT05824767 Recruiting Phase 4 Serum Biomarkers to Predict Response to Angiotensin II in Septic Shock April 17, 2023 October 31, 2024
NCT04470973 Recruiting Pharmacokinetics of Amikacin and Cefuroxime in Critically Ill Patients. July 15, 2020 December 15, 2023
NCT05833607 Recruiting Effects of Targets of Blood Pressure on Cerebral Hemodynamics in Septic Shock July 7, 2022 July 7, 2024
NCT04494074 Recruiting N/A Fever Control Using External Cooling in Mechanically Ventilated Patients With Septic Shock October 1, 2022 December 1, 2026
NCT05839366 Recruiting Phase 3 Adjunctive Esketamine for Analgesia in Mechanically Ventilated Septic Shock Patients May 31, 2023 October 31, 2024
NCT04513288 Recruiting N/A ICITRU : Randomized Trial of Immunonutrition With L-citrulline in Patients Hospitalized in Intensive Care for Sepsis or Septic Shock May 20, 2022 June 20, 2024
NCT05874895 Recruiting N/A MAnual Lymphatic DrAinage to iMprove the outcomE of Patients After Septic Shock June 1, 2023 December 31, 2024
NCT04550143 Recruiting Muscle Ultrasound Study in Shock Patients October 13, 2020 August 2024
NCT05886192 Recruiting Phase 4 The Construction and Application of Therapeutic System of Intelligent Decision-Oriented Hemodynamic Organized Therapy for Shock Patients May 1, 2023 September 30, 2025
NCT05895240 Recruiting Phase 4 Role of Ulinastatin in Preventing Severe Sepsis and Consequent Morbidities and Mortality May 1, 2023 October 2023
NCT04571801 Recruiting N/A Optimization of Sepsis Therapy Based on Patient-specific Digital Precision Diagnostics March 16, 2022 August 31, 2024
NCT05928767 Recruiting Evaluation of the Clinical Frailty Scale (CFS) as a Risk Factor of Mortality in Adult Patients ≤65 Years of Age Admitted to Intensive Care for Septic Shock. August 21, 2023 December 1, 2024
NCT04589546 Recruiting Phase 3 Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock? October 1, 2020 January 2024
NCT04593212 Recruiting Assessment of Microcirculatory Dysfunction in Septic Shock Patients by OCTA February 16, 2023 June 2024
NCT04610853 Recruiting Rotational Thromboelastometry Versus DIC Score in Sepsis November 2, 2020 May 31, 2024
NCT05950984 Recruiting Medical Device (MD) Derived Pharmacokinetic (PK) Parameters for Vancomycin (MD-PK) October 30, 2023 August 2024
NCT06370078 Recruiting N/A Effect of Early Administration of Albumin 20% Versus Crystalloid June 1, 2024 November 30, 2024
NCT06225258 Recruiting Phase 2 Xanthohumol as an Adjuvant in the Treatment of Septic Shock May 9, 2023 June 30, 2024
NCT05969275 Recruiting Phase 2 Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock February 14, 2024 March 31, 2027
NCT04748796 Recruiting N/A Comparison of Landiolol Versus Standard of Care for Prevention of Mortality in Patients Hospitalized for a Septic Shock With Hypercontractility February 1, 2021 March 2024
NCT06226441 Recruiting N/A Aminoglycoside Administration in Septic Patients June 2, 2023 December 2026
NCT04796636 Recruiting Phase 1 High-dose Intravenous Vitamin C in Patients With Septic Shock September 27, 2021 December 22, 2023
NCT05975671 Recruiting N/A Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis August 21, 2023 January 2026
NCT04844801 Recruiting N/A Rate, Rhythm or Risk Control for New-onset Supraventricular Arrhythmia During Septic Shock: a Randomized Controlled Trial November 9, 2021 December 2023
NCT06001294 Recruiting We Collected Blood Samples From Septic Shock Patients and Measured ELABELA, Creatinine, and NGAL Levels. Survival After 7 Days Was Recorded and Analyzed to Evaluate the Potential of Serum ELABELA as an Early Diagnostic Marker for Sepsis-associated Acute Kidney Injury. July 3, 2022 December 31, 2023
NCT06005558 Recruiting Phase 2/Phase 3 Low Dose Versus High Dose Methylene Blue in Septic Patients August 1, 2023 March 15, 2024
NCT04931225 Recruiting Phase 3 LANdiolol MIcrocirculatory Effects During Septic chOc (MILANOS) July 18, 2022 January 2024
NCT04931485 Recruiting N/A Protocolised Early De-Resuscitation in Septic Shock (REDUCE) July 19, 2021 December 31, 2024
NCT06010186 Recruiting N/A Evolution of Muscle Function, Breathlessness and Quality of Life Following Intra or Extra-Abdominal Sepsis in ICU Patients July 28, 2023 December 31, 2025
NCT04963686 Recruiting Simplified Assessment of Left Ventricular Systolic Function in Septic Shock Patients August 1, 2021 November 2023
NCT04963920 Recruiting N/A A RCT to Assess the Performance of CytoSorb for Shock Reversal in Patients With Vasoplegic Septic Shock January 30, 2022 May 2025
NCT06287684 Recruiting Molecular Endotype-Specific Dynamics of Lung Endothelial Barrier Integrity in Sepsis September 13, 2023 December 30, 2025
NCT04997421 Recruiting N/A Safety and Efficacy of HA380 Hemoadsorption in Patients With Septic Shock June 10, 2021 December 2025
NCT05011656 Recruiting N/A Blood Purification for the Treatment of Pathogen Associated Shock April 19, 2024 December 30, 2024
NCT05039151 Recruiting Interstitial Fluid Composition in Patients With Septic Versus Non-septic Shock: an Exploratory Pilot Study January 25, 2021 February 2025
NCT05066256 Recruiting N/A LV Diastolic Function vs IVC Diameter Variation as Predictor of Fluid Responsiveness in Shock September 22, 2021 September 2024
NCT05088109 Recruiting Shock Indices Use for Early Mortality From Septic Shock October 24, 2021 February 2023
NCT05093075 Recruiting Phase 2 Therapeutic Plasma Exchange in Septic Shock: A Pilot Study June 1, 2023 December 2026
NCT06119815 Recruiting N/A CO2 Gap Changes Versus Inferior Vena Cava Collapsibility in Relation to Cardiac Index as a Prognostic Value in Septic Shock October 10, 2023 October 10, 2025
NCT05122884 Recruiting Phase 2 Milrinone Versus Placebo in Patients With Septic Shock December 1, 2021 June 2025
NCT06122909 Recruiting Phase 3 The Effect Of Resuscitation Guided By Two Different Dynamic Parameters On Time To Normalization Of The Capillary Refill Time In Adult Patients With Septic Shock July 21, 2023 July 1, 2024
NCT05143736 Recruiting Nasal and Gut Microbiota Combined Clinical Events Predicts the Prognosis of Septic Patients January 10, 2022 January 31, 2025
NCT05146336 Recruiting CytOSorb TreatMent Of Critically Ill PatientS Registry June 22, 2022 September 2032
NCT05148286 Recruiting Phase 4 Albumin and Crystalloid Administration in Septic Shock January 17, 2022 December 31, 2024
NCT06122987 Recruiting Phase 4 Hemodynamic Response to Angiotensin-II When Used as the Second Vasopressor Agent for Septic Shock December 4, 2023 January 2025
NCT05184296 Recruiting N/A ExtraCorporeal Membrane Oxygenation in the Therapy for REfractory Septic Shock With Cardiac Function Under Estimated May 1, 2023 May 31, 2026
NCT05194189 Recruiting Phase 2 Clinical Efficacy of Megadose Vitamin C in Sepsis February 8, 2022 December 4, 2024
NCT03334006 Recruiting Phase 2 Prospective, Randomized Trial of Personalized Medicine With Pentaglobin® After Surgical Infectious Source Control in Patients With Peritonitis (PEPPER Trial). November 20, 2017 March 2028
NCT05202938 Recruiting eMESH Struct. 2022-23 July 21, 2022 July 21, 2024
NCT05207280 Recruiting Phase 3 Clinical Trial Comparing Noradrenaline (NA) Plus Placebo Versus Noradrenaline Plus Terlipressin (TP) in Septic Shock October 11, 2022 November 2024
NCT05208242 Recruiting Phase 2/Phase 3 Strong Albumin Solutions in Patients With Septic Shock November 10, 2023 February 28, 2026
NCT03401398 Recruiting Phase 3 Stress Hydrocortisone In Pediatric Septic Shock March 11, 2019 December 31, 2026
NCT03405870 Recruiting Phase 1/Phase 2 LIPIDS-P Trial Phase I/II August 17, 2018 December 1, 2022
NCT05257759 Recruiting N/A Use of Neurostimulation as a Tool for Reconditioning the Neuromuscular System of Patients Admitted to the ICU for Septic Shock March 25, 2022 April 2025
NCT06140147 Recruiting N/A Protocolized Reduction of Non-resuscitation Fluids Versus Usual Care in Septic Shock Patients November 27, 2023 July 1, 2028
NCT06145828 Recruiting Clinical Application of Cytokine Adsorption Technique in AIDS Patients With Severe Pneumonia and/or Septic Shock October 23, 2023 October 23, 2027
NCT06363149 Recruiting Disseminated Intravascular Coagulation (DIC) Score and Organ Dysfunction in Septic Shock Patients April 12, 2024 September 2025
NCT03472079 Recruiting TIMP2*IGFBP7 and Transient AKI May 1, 2017 December 1, 2024
NCT03736421 Suspended Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervolemic Emergency Department Patients November 10, 2018 April 2021
NCT04742764 Suspended Phase 3 Extracorporal Cytokin Removal in Septic Shock: a Prospective, Randomized, Multicenter Clinical Trial January 1, 2024 October 31, 2027
NCT05001854 Suspended Phase 2/Phase 3 Hemodynamics Effects of Fludrocortisone on the Pressor Response to Noradrenaline Septic Shock Patients March 31, 2022 December 2024
NCT03302650 Suspended Phase 3 Angiotensin II for Septic Shock Treatment April 1, 2019 August 15, 2019
NCT02825329 Temporarily not available Open-label Evaluation of Polymyxin B Hemoperfusion for Septic Shock
NCT03582046 Terminated N/A Targeting Abdominal Perfusion Pressure in Septic Shock February 5, 2019 June 20, 2020
NCT02237833 Terminated Cerebral Oxygenation in Septic Patients Using Vasopressors - the Conscious Study February 2015 January 2017
NCT03378466 Terminated Phase 2 Heparin Anticoagulation in Septic Shock March 12, 2018 December 31, 2021
NCT02508649 Terminated Phase 2/Phase 3 Selepressin Evaluation Programme for Sepsis-Induced Shock - Adaptive Clinical Trial July 2015 February 26, 2018
NCT04759989 Terminated N/A Fluid Resuscitation in Septic Shock Patients With BMI Elevation June 1, 2021 May 25, 2022
NCT01271114 Terminated Phase 3 Hypertonic Saline and Terlipressin for Sepsis-associated Hypotension June 2012 December 2013
NCT04117568 Terminated The Role of Emergency Neutrophils and Glycans in Postoperative and Septic Patients September 4, 2019 April 1, 2020
NCT03828929 Terminated Phase 3 Effect of IV Vitamin C, Thiamine, and Steroids on Mortality of Septic Shock October 15, 2019 February 4, 2020
NCT01223430 Terminated Phase 2 Simultaneously Using Traditional Chinese Medicine (Si-Ni-Tang) to Treat Septic Shock Patients September 2010 February 2012
NCT01957254 Terminated Investigate the Activity of Endotoxin in Severe Sepsis January 2013 December 2016
NCT01455116 Terminated Phase 2/Phase 3 The Cooling And Surviving Septic Shock Study (CASS) November 2011 November 2016
NCT01193777 Terminated Phase 1 L-Carnitine Administration in Early Sepsis September 2010 February 2012
NCT03380507 Terminated Phase 2/Phase 3 Evaluation of Hydrocortisone, Vitamin C and Thiamine for the Treatment of Septic Shock March 17, 2018 November 1, 2021
NCT01787045 Terminated N/A Early Physical Therapy in Patients With Sepsis February 2013 November 2015
NCT02576457 Terminated Phase 1 Safety, Pharmacokinetics and Pharmacodynamics of BMS-936559 in Severe Sepsis December 2, 2015 March 15, 2017
NCT01682590 Terminated Phase 3 I.D.E.A.L.-I.C.U. (Initiation of Dialysis EArly Versus deLayed in Intensive Care Unit) July 2012
NCT02317549 Terminated Phase 2 Treatment of Septic Shock by Inhibiting Autodigestion and Preserving Gut Integrity With Enteric LB1148 April 2015 March 2016
NCT03706053 Terminated Phase 3 Midodrine Use in Septic Shock November 5, 2018 February 11, 2022
NCT02335723 Terminated N/A ASSET - a Double-Blind, Randomized Placebo-Controlled Clinical Investigation With Alteco® LPS Adsorber September 2015 April 28, 2017
NCT03895853 Terminated Phase 2 Early Metabolic Resuscitation for Septic Shock October 4, 2019 May 4, 2020
NCT03335124 Terminated Phase 4 The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock September 26, 2017 December 1, 2018
NCT01493102 Terminated N/A Discontinuation Order of Vasopressors in Septic Shock December 2011 December 2013
NCT05192213 Terminated Phase 3 Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock August 1, 2021 September 19, 2022
NCT04961658 Terminated Phase 1 Advanced Mesenchymal Enhanced Cell THerapY for SepTic Patients August 11, 2021 January 8, 2024
NCT02357433 Terminated N/A Mortality Reduction in Septic Shock by Plasma Adsorption February 2015 June 2018
NCT02875236 Terminated Phase 4 Vasculopathic Injury and Plasma as Endothelial Rescue in Septic Shock Trial. VIPER-Sepsis (EudraCT no. 2016-000707-81) September 1, 2016 November 8, 2016
NCT01150409 Terminated Phase 4 Hemodynamic and Inflammatory Effects of Abrupt Versus Tapered Corticosteroid Discontinuation in Septic Shock May 2008 August 2010
NCT00816790 Terminated Phase 4 Standard Vs Adjusted Dosing of Piperacillin/Tazobactam in Acute Renal Failure and Septic Shock January 2009 June 2011
NCT01722422 Terminated N/A Hyperoxia and Hypertonic Saline in Septic Shock October 2012 September 2014
NCT02369900 Terminated Phase 2 Esmolol to Treat the Hemodynamic Effects of Septic Shock March 2015 December 31, 2019
NCT01817153 Terminated Phase 2/Phase 3 Effect of Hydrocortison on Post-ischemic Flow-mediated Dilation and on Thenar Oxygen Saturation in Human Septic Shock. November 5, 2013 November 5, 2019
NCT03953677 Terminated Phase 3 Evaluation of the Effect of Dexmedetomidine on Phenylephrine Response During Refractory Septic Shock October 27, 2019 March 22, 2023
NCT02668432 Terminated Phase 4 Use of Amiodarone in Atrial Fibrillation Associated With Severe Sepsis or Septic Shock May 2016 September 20, 2018
NCT00842933 Terminated Phase 4 Adrenal Insufficiency in Septic Shock May 2007 May 2011
NCT00535821 Terminated Phase 4 Minimally-Invasive Cardiovascular Hemodynamic Optimization (MiCHO) Versus Early Goal-Directed Therapy (EGDT) in the Management of Septic Shock June 2007 September 2010
NCT03280992 Terminated Community Acquired Sepsis Cohort March 2, 2016 August 27, 2018
NCT03366220 Terminated Phase 2 Resuscitation With Plasma in Surgical and Trauma Patients With Septic Shock March 26, 2018 October 16, 2019
NCT01296789 Terminated N/A Comparison of a Tissue Perfusion Guided Hemodynamic Protocol With a Standard Hemodynamic Protocol in Septic Shock Patients February 2011 April 2013
NCT01315496 Terminated Phase 3 GCIV as an Adjuvant Therapy for Community-Acquired Severe Sepsis or Septic Shock October 2009 December 2013
NCT03311568 Terminated N/A Microcirculatory Alterations in Critical Disease: New Ultrasound Technology October 31, 2017 November 1, 2019
NCT02731144 Terminated Phase 4 Optimized Caloric-proteic Nutrition in Septic and Septic Shock Patients June 2016 February 2018
NCT04434209 Terminated Phase 4 A Study Looking at the Use of Biomarkers to Provide Early Indication of Acute Kidney Injury in Patients With Sepsis (Limiting AKI Progression In Sepsis) January 19, 2021 February 14, 2022
NCT05612529 Terminated Fluid Responseveness in Sepsis and Its Correlation to CVP April 1, 2022 November 30, 2022
NCT04134624 Terminated N/A EMS Prehospital Blood Culture Collection and Antibiotic Administration: A Two-Phase Pilot Project to Reduce Mortality in Patients With Severe Sepsis and Septic Shock September 11, 2019 July 8, 2021
NCT01371929 Terminated Plasma Inducible Nitric Oxide Synthase (iNOS) Assay and Sepsis Study February 4, 2013 September 30, 2015
NCT01856517 Terminated Phase 2/Phase 3 Upregulation of Alpha-1 Receptors Upon Septic Shock? August 2013 September 2014
NCT02203630 Terminated Phase 4 Phenylephrine Versus Norepinephrine for Septic Shock in Critically Ill Patients August 2014 January 2016
NCT03151668 Unknown status Phase 3 Effect of Dexmedetomidine on Perfusion Index and Microcirculation in Severe Sepsis and Septic Shock Patients January 4, 2017 April 2018
NCT02195830 Unknown status N/A Inferior Vena Cava Collapsibility Index in Severe Sepsis July 2014 July 2015
NCT03640468 Unknown status Phase 3 Lidocaine as an Adjuvant for Ketamine in Induction of Anesthesia in Septic Shock Patients December 20, 2018 July 1, 2019
NCT02240277 Unknown status Meropenem and Ciprofloxacin Dosing in Septic Shock November 2014 March 2016
NCT03177330 Unknown status Safety and Efficacy of Heparin Dosing Score Protocol for Polymyxin-B Hemoperfusion May 15, 2017 July 2017
NCT03189355 Unknown status N/A Expression of Protein Tyrosine Phosphatase 1B (PTP1B) and Body Composition Modification in Patients With Septic Shock January 9, 2017 February 9, 2019
NCT03198611 Unknown status Reversibility of Diastolic Disfunction in Septic Shock March 1, 2018 April 1, 2019
NCT02306239 Unknown status N/A The Effect of Terlipressin on Intesitnal Function in Septic Shock Patients December 2014
NCT03208257 Unknown status Phase 2 Esmolol to Control Adrenergic Storm in Septic Shock- ROLL-IN 2 August 7, 2017 June 2021
NCT03434691 Unknown status N/A Effects of Dexmedetomidine vs Midazolam on Microcirculation in Septic Shock Patients February 8, 2018 December 31, 2018
NCT05217836 Unknown status Iron Metabolism Disorders in Patients With Sepsis or Septic Shock. September 24, 2021 December 31, 2022
NCT05225402 Unknown status Hemodynamic Measurements of Macrocirculatory and Perfusion Parameters in ICU March 8, 2022 August 30, 2023
NCT04690530 Unknown status Cerebral Hemodynamics and Oxygenation in Critically Ill Patients March 1, 2022 March 1, 2022
NCT04693923 Unknown status N/A Capillary Refill Time Response to a Rapid Fluid Challenge in Septic Shock Patients February 1, 2021 September 1, 2023
NCT04695119 Unknown status Sepsis in the ICU-II September 17, 2018 December 31, 2023
NCT04710914 Unknown status Phase 4 Comparison of Extubation Delay After Prolonged Sedation December 15, 2020 March 31, 2023
NCT04716842 Unknown status Evaluation of Plasma Angiotensin II and Angiotensin II Receptor Levels in Patients With Sepsis and Septic Shock: a Prospective Observational Study. January 1, 2021 April 2021
NCT04728529 Unknown status N/A Septic Shock Management Guided by Ultrasound: SEPTICUS Trial September 2, 2021 June 2023
NCT05159154 Unknown status Myocardial Work in Septic Shock Patients January 1, 2022 January 1, 2023
NCT05231720 Unknown status Mannheim Register of Sepsis and Septic Shock December 3, 2019 December 2023
NCT02478073 Unknown status Piperacillin Pharmacokinetics in ICU Patients June 2015 May 2016
NCT02508350 Unknown status N/A The Pharmacokinetics/Pharmacodynamics of High-dose Daptomycin in Patients With Septic Shock January 2015 June 2016
NCT03252613 Unknown status Translational Approaches to Septic Cardiomyopathy May 19, 2017 October 27, 2019
NCT02547467 Unknown status TOADS Study: TO Assess Death From Septic Shock. September 2015 May 2016
NCT04774705 Unknown status N/A Effectiveness of Non-invasive Vagus Nerve Stimulation as an Adjuvant Treatment in Patients With Sepsis in Intensive Care. March 29, 2021 March 29, 2023
NCT02565251 Unknown status N/A Volemic Resuscitation in Sepsis and Septic Shock September 2015 September 2017
NCT04778605 Unknown status Modulation of Endothelial Dysfonction Using Vitamin C in Septic Shock Patients January 26, 2021 July 2021
NCT00449800 Unknown status Phase 4 Pharmacokinetic of Ceftriaxone in Septic ICU Patients July 2006 March 2007
NCT05190861 Unknown status N/A Evaluation of Droplet Digital PCR Rapid Detection Method and Precise Diagnosis and Treatment for Suspected Sepsis November 29, 2021 June 1, 2023
NCT02612181 Unknown status Phase 4 Dex on Microcirculation in SS-A Double-blinded Study January 2016 December 2017
NCT02612363 Unknown status Phase 4 Early Goal Directed Sedation on Microcirculation in Septic Shock November 2015 December 2016
NCT03634293 Unknown status Phase 2/Phase 3 Treatment of Severe Infection With Antihyperlipidemia Drug January 2019 February 2021
NCT00450840 Unknown status Phase 4 Simvastatin in Patients With Septic Shock
NCT02640846 Unknown status Phase 4 Effects of Levosimendan, Milrinone and Norepinephrine on Left and Right Ventricular Function in Septic Shock December 2015 January 2019
NCT04870892 Unknown status Effects of Norepinephrine and Volume Expansion in Capillary Refill Time in Septic Shock January 15, 2021 December 31, 2022
NCT03623529 Unknown status Phase 2 A Study of LJPC-501 in Paediatric Patients With Hypotension Associated With Distributive or Vasodilatory Shock August 2018 April 2023
NCT02676427 Unknown status Fluid Responsiveness in Septic Shock Evaluated by Caval Ultrasound Doppler Examination September 2015 June 2021
NCT02692053 Unknown status N/A Characterization of Hemostatic Disordres in Septic Shock: Searching for Biological Markers February 2016 February 2018
NCT02706379 Unknown status N/A Impact of Early Goal-Directed Therapy to Perfusion and Metabolism of Brain June 2015 April 2016
NCT04903405 Unknown status Immune Function Monitoring and Immunotherapy in Sepsis June 1, 2021 July 30, 2021
NCT04913181 Unknown status Artificial Intelligence for Sepsis Prediction in ICU June 1, 2021 June 1, 2023
NCT03752489 Unknown status Phase 2 Unsupervised Machine Learning for Clustering of Septic Patients to Determine Optimal Treatment April 1, 2022 March 31, 2024
NCT04915625 Unknown status A Prediction Model of 28-day Mortality in Septic Shock December 1, 2020 December 31, 2022
NCT03749525 Unknown status Phase 2/Phase 3 Shenfu Injection Improves Arterial Vascular Reactivity December 1, 2018 September 2019
NCT03762005 Unknown status N/A Peripheral Perfusion Versus Lactate Targeted Fluid Resuscitation in Septic Shock June 1, 2018 December 31, 2019
NCT04921319 Unknown status N/A De-resuscitation Informed by Ultrasound for Patients With Sepsis April 26, 2021 July 30, 2022
NCT03782454 Unknown status Quantification of Bacterial DNA in Sepsis January 7, 2019 May 31, 2022
NCT03557229 Unknown status Phase 3 Clinical Trial of Antioxidant Therapy in Patients With Septic Shock July 23, 2018 June 2022
NCT03802136 Unknown status Multiple Biomarkers in ICU Sepsis Patients December 30, 2018 June 2019
NCT05443854 Unknown status Phase 3 Impact of Aminoglycosides-based Antibiotics Combination and Protective Isolation on Outcomes in Critically-ill Neutropenic Patients With Sepsis: (Combination-Lock01) September 2022 June 2024
NCT03837171 Unknown status Phase 3 TRANSfusion in Patients With Onco-hematological Malignancies ResusciTated From Septic Shock March 24, 2019 February 20, 2022
NCT03837730 Unknown status Citrulline and Arginase Activity in Severe Sepsis and Septic Shock February 10, 2019 August 10, 2019
NCT03847493 Unknown status Analysis of Sublingual Glycocalyx Damage at ICU Admission to Predict Risk of Death April 15, 2019 December 31, 2023
NCT02820987 Unknown status Phase 3 PK/PD of Extended-infusion Meropenem, Piperacillin-tazobactam and Cefepime in the Early Phase of Septic Shock September 1, 2016 September 1, 2018
NCT03866083 Unknown status N/A Safety and Efficacy of Extracorporeal Cytokine Hemoadsorption in Septic Shock in Critically Ill Cirrhotics March 1, 2019 June 30, 2019
NCT03869385 Unknown status Phase 3 Albumin Replacement Therapy in Septic Shock October 21, 2019 January 30, 2023
NCT03727243 Unknown status Molecular Diagnosis and Risk Stratification of Sepsis in India December 6, 2018 June 11, 2021
NCT05315557 Unknown status N/A Efficacy and Safety of Vasopressin Versus Terlipressin as a Second Vasopressor in Critically Ill Cirrhotics With Septic Shock- the VITEL-C Trial April 5, 2022 March 31, 2023
NCT03898674 Unknown status N/A Microcirculatory Guided Goal Directed Fluid Therapy in Septic Shock; a Feasibility Study February 5, 2019 October 1, 2020
NCT03617965 Unknown status Mortality Due to Septic Shock Associated With Thrombocytopenia August 15, 2018 December 31, 2019
NCT03716895 Unknown status Severe Septic Shock Complications December 2018 March 2020
NCT02871895 Unknown status Application of Biomarkers Change to Predict Outcome of Patient With Severe Sepsis July 2013 December 2018
NCT03308227 Unknown status Plasma and Lung Tissue Concentrations of Linezolid in Septic Shock Patients October 20, 2017 April 30, 2018
NCT03715556 Unknown status Phase 3 Control Versus Liberal Cardiac Frequency in Patients in Sepse With Atrial Fibrillation of High Ventricular Response December 1, 2018 December 1, 2021
NCT02883803 Unknown status N/A Treatment of Severe Infections With Mesenchymal Stem Cells December 2019 November 2022
NCT00837057 Unknown status Phase 4 Early Continuous Renal Replacement Therapies (CRRT) in Patients With Severe Sepsis or Septic Shock With Acute Kidney Injury February 2009
NCT03961594 Unknown status N/A Evaluation of New Hemodynamic Indices July 19, 2018 January 1, 2020
NCT03966664 Unknown status Determination of the Dissociation Constant (Ka) of Plasma and Whole Blood in Septic Patients June 3, 2019 June 2021
NCT00378586 Unknown status Barrier Function and Production of Inflammatory Cytokines in the Rectal Mucosa in Patients With Septic Shock January 2010
NCT03713307 Unknown status Macro and Micro Haemodynamic Responses to Shock in the Renal and Systemic - MICROSHOCK - RENAL November 27, 2018 November 2020
NCT05357339 Unknown status N/A Microcirculation Properties of Albumin for Fluid Resuscitation in Septic Shock September 1, 2021 November 30, 2022
NCT04970602 Unknown status N/A The Effect of Early Use of Methylene Blue on Hemodynamics in Septic Shock June 20, 2021 January 1, 2024
NCT04259567 Unknown status N/A Improvement of Cerebrovascular Autoregulation in Patients With Septic Shock Due to Cytokine Elimination June 8, 2020 July 31, 2022
NCT01539551 Unknown status Investigation of the Role of Brain Natriuretic Peptide and Lactate in Early Goal-directed Therapy for Patients With Severe Sepsis and Septic Shock February 2012 January 2013
NCT04282252 Unknown status Phase 4 The Effect of Restrictive Fluid Management on Cardiac Function and Glycocalyx Degradation February 24, 2020 April 2022
NCT03336814 Unknown status Phase 4 Evaluation of Early Association of Terlipressin and Norepinephrine During Septic Shock; the TerliNor Study July 27, 2018 June 1, 2019
NCT03457038 Unknown status N/A Use of Fc-MBL to Detect and Monitor the Presence of PAMPs During Septic Shock October 18, 2018 July 18, 2019
NCT04295993 Unknown status Phase 3 Methylene Blue and Microcirculation in Septic Shock March 10, 2020 September 20, 2020
NCT03668236 Unknown status Phase 4 The Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care Trial November 27, 2018 November 2022
NCT05042622 Unknown status N/A Organ-substituting Technologies in the Treatment of Heart and Pulmonary Failure January 1, 2021 December 31, 2023
NCT03038503 Unknown status Phase 3 What Should be the Next Vasopressor for Severe Septic Shock? Methylene Blue or Terlipressin December 2016 December 2018
NCT04319965 Unknown status Complications Related to Transpulmonary Thermodilution February 8, 2020 June 30, 2023
NCT01685112 Unknown status Comparison of ECMO Use and Conventional Treatment in Adults With Septic Shock September 2012 August 2013
NCT01697410 Unknown status N/A Continuos Terlipressin Infusion in Septic Shock January 2013 January 2016
NCT01724463 Unknown status Electronic Application of a Severe Sepsis Screening Tool and Management Bundle March 2013 October 2018
NCT01747187 Unknown status Cardiac Stress in Septic Shock - Biomarkers, Echocardiography and Outcome October 2012 April 2015
NCT01770457 Unknown status Cytokine Response in Septic Shock April 2006 December 2014
NCT05057611 Unknown status N/A Hemodynamic Phenotype and Capillary Refill Time-targeted Resuscitation Strategy March 18, 2022 December 2023
NCT01775956 Unknown status A Retrospective Review of a Comprehensive Cohort of Septic Shock: Assessment of Critical Determinants of Outcome December 2003 July 2018
NCT03065751 Unknown status N/A Plasmaexchange in Early Septic Shock January 2016 July 2021
NCT01797978 Unknown status Phase 3 Methylene Blue in Severe Sepsis and Septic Shock February 2013 March 2017
NCT03661268 Unknown status N/A The Effect of Rapid Fluid Challenge Under Pulmonary Artery Catheter Monitoring on Physiological Indexes of Patients With Septic Shock October 1, 2018 September 30, 2021
NCT01823484 Unknown status N/A Effects of AN69 ST Hemofilter on Coagulation During Continuous Renal Replacement Therapy in Critically Ill January 2012
NCT04365010 Unknown status Phase 4 Low-chlorine Vs High-chlorine Crystalloids in Septic Shock Adults May 2020 December 2021
NCT04366921 Unknown status European/Euro-ELSO Survey on Adult and Neonatal/ Pediatric COVID-19 Patients in ECMO April 10, 2020 April 2022
NCT01839578 Unknown status N/A Citrate Versus Heparin Anticoagulation: Effect on Molecules Clearances May 2013 April 2015
NCT01841190 Unknown status Prognostic Evaluation Of Severe Sepsis And Septic Shock. Procalcitonin Versus Delta Sofa May 2012
NCT01849237 Unknown status Phase 1/Phase 2 Russian Clinical Trial of Mesenchymal Cells in Patients With Septic Shock and Severe Neutropenia December 2012 May 2015
NCT01858909 Unknown status Phase 3 Efficacy of Melatonin in Patients With Severe Sepsis or Septic Shock May 2013 December 2013
NCT01862588 Unknown status Renal Resistive Index and Cardiac Output Changes During Resuscitation Predict the Occurrence of Acute Kidney Injury in Septic Shock Patients January 2013 January 2014
NCT00384644 Unknown status Skeletal Muscle Oxygenation in Critically Ill April 2004 December 2010
NCT01877798 Unknown status N/A Venoarterial PCO2 Difference /Arteriovenous O2 Content Difference Ratio as Goal of Early Septic Shock Therapy June 2013
NCT04425161 Unknown status Ratio of ''Central Venous-to-Arterial Co2 Gap'' to ''Arterial-to-Central Venous O2 Content Gap'' in Septic Shock July 20, 2020 December 2021
NCT01920776 Unknown status N/A Focused Ultrasound in Septic Shock Patients July 2013
NCT03589378 Unknown status N/A Therapeutic Plasma Exchange Adsorption Diafiltration August 13, 2018 September 30, 2020
NCT04449757 Unknown status N/A Bicarbonated Ringer's Solution Versus Lactated Ringer's Solution in Patients With Septic Shock July 1, 2020 May 30, 2021
NCT03540628 Unknown status N/A Thiamine, Vitamin C and Hydrocortisone in the Treatment of Septic Shock February 26, 2018 February 26, 2020
NCT03578835 Unknown status Bloodstream Infection Due to Multidrug-Resistant Organisms - Multicenter Study on Determinants of Clinical Outcomes February 1, 2017 June 30, 2019
NCT05080543 Unknown status Phase 1 Microcirculation Recruitment Using Albumin 20% and Terlipressin in Septic Patients October 2021 October 2022
NCT02002676 Unknown status Prevalence and Outcome of Hypermetabolism in Initial Prevalence and Outcome of Hypermetabolism in Initial Phase of Intensive Care Unit Patient: a Prospective Observational Study December 2013 June 2014
NCT03547414 Unknown status Does Urinary TIMP2 and IGFBP7 Can Identify High Risk Patients of Progression From Mild and Moderate to Severe Acute Kidney Injury During Septic Shock? August 16, 2018 December 30, 2018
NCT04474431 Unknown status N/A Correlation of VEGF-A and Fluid Balance in Septic Shock December 24, 2019 January 24, 2022
NCT03369275 Unknown status Phase 2 Cellular Immunotherapy for Septic Shock March 2018 October 2020
NCT03113721 Unknown status Assessment of Heparin Binding Protein for the Prediction of Severe Sepsis March 27, 2017 March 1, 2019
NCT03654001 Unknown status Phase 3 ALBumin Italian Outcome Septic Shock-BALANCED Trial (ALBIOSS-BALANCED) May 7, 2019 February 28, 2022
NCT02060773 Unknown status Effect of EGDT on Hepatic Perfusion in Patients With Septic Shock December 2012 February 2014
NCT02068287 Unknown status Phase 2 Esmolol Effects on Heart and Inflammation in Septic Shock December 2013 June 2017
NCT04515511 Unknown status N/A Whether a Minimal Volume Could Predict Fluid Responsiveness Using Thermodilution by PAC in Septic Shock Patients July 1, 2019 September 2022
NCT04516395 Unknown status N/A Optimizing Antibiotic Dosing Regimens for the Treatment of Infection Caused by Carbapenem Resistant Enterobacteriaceae September 2020 April 2021
NCT00793559 Unknown status Phase 2 Terlipressin Administration in Septic Shock Refractory to Catecholamines November 2008 July 2009
NCT02135796 Unknown status Echocardiography in Septic Shock October 2008 December 2019
NCT02150512 Unknown status N/A Resuscitation Strategies in Septic Shock November 2014 December 2016
NCT05136183 Unknown status N/A CLinical Efficacy of Hemoperfusion With a Cytokine Adsorber in Norepinephrine-Resistant SEptic Shock December 15, 2021 November 30, 2023
NCT05325957 Unknown status Effects of Norepinephrine and Volume Expansion in Capillary Refill Time in Septic Shock in Angers University Hospital May 2022 June 2024
NCT01304680 Unknown status Evaluation of Fluid Resuscitation in Children With Cancer With Severe Sepsis / Septic Shock January 2011
NCT01312688 Unknown status N/A Early Goal-directed Therapy and Myocardial Dysfunction July 2011 December 2013
NCT02962700 Unknown status N/A Effects of Continuous Haemofiltration vs Intermittent Haemodialysis on Microcirculatory Parameters in Septic Shock January 2016 December 2018
NCT04136080 Unknown status N/A The Effect of Increasing the Mean Arterial Pressure on the Microcirculation and the Prognosis of Patients With Septic Shock December 1, 2019 November 30, 2021
NCT04141410 Unknown status Global Longitudinal Strain Assessment in Cardiogenic Shock During Sepsis October 21, 2019 January 21, 2021
NCT00711789 Unknown status Phase 2 Angiotensin in Septic Kidney Injury Trial February 2010
NCT04152174 Unknown status N/A Safety and Efficiency of Combined Extracorporeal Blood Purification in Neurosurgical ICU. Prospective RCT April 10, 2018 November 10, 2021
NCT00093301 Unknown status Phase 2/Phase 3 Levosimendan Versus Dobutamine in Shock Patients October 2004 April 2006
NCT02963454 Unknown status N/A Effects of Levosimendan on Cellular Metabolic Alterations in Patients With Septic Shock January 2011 February 2018
NCT04156451 Unknown status N/A Effect of Fluid Deresuscitation With Central Venous Pressure Target 0-4 mmHg in Septic Shock Patients November 14, 2019 November 30, 2020
NCT02972827 Unknown status N/A Monitoring Devices in Prediction of Fluid Responsiveness in Severe Sepsis and Septic Shock May 2015 May 2022
NCT04203524 Unknown status N/A Procalcitonin and Antimicrobial Utilization in Critically Ill Cancer Patients With Sepsis August 21, 2019 September 21, 2023
NCT04204694 Unknown status Study of the Role of Interferon αon the Endothelial Dysfunction During Septic Shock July 1, 2020 April 1, 2023
NCT04231695 Unknown status Extracorporeal Cytokine Removal in Patients With Septic Shock in an Adult Intensive Care Unit December 1, 2019 December 2021
NCT04999137 Unknown status Phase 2 Evaluation of Safety and Dosing of a Vitamin C Bundle for Sepsis Treatment in Africa September 1, 2021 December 29, 2021
NCT04239937 Unknown status Insulin Resistance in Stress-metabolic Medical Patients February 18, 2020 August 27, 2020
NCT01486524 Unknown status Pharmacogenomic Biomarker Study for Recombinant Human Activated Protein C Treatment in Severe Sepsis October 2011 April 2012
NCT04257838 Unknown status Monitoring of Piperacillin-Tazobactam and Meropenem Plasmatic Levels in Critical Patients February 15, 2020 March 15, 2021
NCT04005001 Unknown status Phase 2 Machine Learning Sepsis Alert Notification Using Clinical Data September 25, 2021 August 31, 2022
NCT05310942 Unknown status Non Invasive Evaluation of Fluid Responsiveness in Septic Patient December 17, 2021 January 1, 2023
NCT04015752 Unknown status Sepsis in ICU:Causes and Outcomes of Sepsis in Diabetics Versus Non Diabetics in Assiut University Hospital August 2019 October 2020
NCT04031573 Unknown status Phase 3 Ivabradine for Heart Rate Control In Septic Shock February 24, 2021 March 24, 2023
NCT02887274 Unknown status Application of Stimulated Immune Response Change to Predict Outcome of Patient With Severe Sepsis July 2013 December 2018
NCT02899143 Unknown status Phase 2 Short-course Antimicrobial Therapy in Sepsis September 2016 October 2021
NCT05327881 Unknown status Serum Rennin Kinetics Versus Serum Lactate Kinetics as Predictors of Mortality in Septic Shock Patients June 30, 2022 December 30, 2023
NCT04979767 Unknown status Function of Circulating Exosomes in Sepsis-induced Immunosuppression April 15, 2021 June 30, 2022
NCT04107402 Unknown status N/A PLatelets Acetyl-CoA Carboxylase Phosphorylation State in SEPtic Shock March 15, 2019 March 15, 2024
NCT05289388 Unknown status a Novel Index for Tissue Perfusion in Predicting Outcome in Patients With Septic Shock March 2022 June 2022
NCT03685214 Unknown status N/A Comparison of Balanced Crystalloids and Normal Saline in Septic Patients March 1, 2019 May 2021
NCT04134403 Unknown status Phase 3 Steroids, Thiamine and Ascorbic Acid in Septic Shock December 1, 2019 December 1, 2020
NCT01063010 Withdrawn N/A Pilot Study of Bevacizumab (Avastin) in Patients With Septic Shock February 2010 January 2015
NCT02069288 Withdrawn Phase 3 Effects of Fludrocortisone on Norepinephrine-mean Arterial Pressure Dose-response in Septic Shock February 2014
NCT02990546 Withdrawn Phase 3 Midodrine in the Recovery Phase of Septic Shock March 1, 2017 May 2, 2018
NCT05193370 Withdrawn Phase 4 Angiotensin II vs. Vasopressin in Septic Shock January 3, 2022 November 30, 2022
NCT02699905 Withdrawn Neutrophil FFA2/GPR43 Receptor Expression in Patients With the Diagnosis of Sepsis August 2016 November 2017
NCT02885688 Withdrawn Phase 2 Early Metabolic Support as a Potential Solution to Multi-Organ Dysfunction Syndrome (MODS) During Severe Sepsis October 2016
NCT04320394 Withdrawn N/A Evaluation of Sepsis-induced Immunosuppression Base on QuantiFERON Monitor® in Septic Shock July 1, 2020 July 1, 2022
NCT03122678 Withdrawn Phase 1 Thiamine Supplementation in Patients With Septic Shock November 5, 2016 March 14, 2019
NCT04698382 Withdrawn Impact of COVID-19 on the Incidence, Characteristics, Management and Outcome of Sepsis August 1, 2020 December 31, 2023
NCT00814112 Withdrawn Glycosaminoglycans During Septic Shock - a Temporal Study November 2008 November 2010
NCT03882476 Withdrawn Phase 2 RCT of Sepsis Machine Learning Algorithm January 1, 2020 February 28, 2021
NCT03734484 Withdrawn Phase 2 Gram Type Infection-Specific Sepsis Identification Using Machine Learning May 1, 2022 March 1, 2023
NCT03644940 Withdrawn Phase 2 Subpopulation-Specific Sepsis Identification Using Machine Learning December 2020 July 2021
NCT03835286 Withdrawn Phase 3 Vitamin C to Reduce Vasopressor Dose in Septic Shock March 1, 2019 December 2022
NCT01926301 Withdrawn Cerebrovascular Autoregulation in Sepsis, Influence of Renal Replacement Therapy August 2013 June 2020
NCT01573806 Withdrawn Phase 1/Phase 2 Pharmacology of Exenatide in Pediatric Sepsis October 2012 October 2014
NCT03817281 Withdrawn Collective Accuryn Physiologic Signals and Signatures March 29, 2020 March 29, 2020
NCT03621449 Withdrawn Velocity Time Integral vs PICCO for Evaluation of Passive Leg Raising in Septic Shock September 1, 2021 December 30, 2022
ICD10 preferred id (Insert disease from ICD10)
id-SRFSFto-be-added-later-1249570976809-2
ICD10 class code (Insert disease from ICD10)
R57.2