Disase Detail : MGeND

Information

Disease name: exfoliation syndrome
Disease ID: DOID:13641
Description: "A phacogenic glaucoma that is characterized by open-angle glaucoma related to deposition of extracellular fibrillar material in anterior segment structures, which blocks aqueous fluid outflow, raises intraocular pressure, and leads to eventual optic nerve atrophy and visual field loss. Exfoliation syndrome has_symptom progressive decreased vision, especially peripheral vision. Exfoliation syndrome is caused by age-related deposition of fibrillar material in anterior segment structures." [url:https\://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157521/]

Disease area statistics

[No Data.]

Chromosome band

[No Data.]

Annotation

Genes	Mutation	Description	Source	Links

NCT ID	Status	Phase	Summary	Start date	Completion date
NCT00273442	Completed	Phase 4	Assessing Cosopt Switch Patients	November 2005	April 2007
NCT00331240	Completed	Phase 3	24-Hour Intraocular Pressure (IOP) Control With Travoprost/Timolol Fixed Combination	March 2006	February 2007
NCT01126203	Completed	Phase 3	Randomized Prospective Study of Selective Laser Trabeculoplasty (SLT) Versus Argon Trabeculoplasty (ALT) in Patients With Pseudoexfoliation Glaucoma and Ocular Hypertension	September 2006	October 2009
NCT01936389	Completed	Phase 2	A Prospective Study to Assess the Hypotensive Efficacy of Rho-Kinase Inhibitor AR-12286 Ophthalmic Solution 0.5% and 0.7% in Patients With Exfoliation Syndrome and Ocular Hypertension or Glaucoma	September 2013	October 2014
NCT01022281	Completed		Early Diagnosis in Glaucoma With GDxVcc	September 2007	December 2012
NCT01023997	Completed		Central Corneal Thickness in Glaucoma	January 2008	January 2013
NCT02042703	Terminated		Imaging Lens Deposits in Exfoliation Syndrome	February 2014	September 2015
NCT00804115	Unknown status	N/A	The International Collaborative Exfoliation Syndrome Treatment Study	August 2000	December 2008

exfoliation syndrome