Astrocytoma
Information
- Disease name
- Astrocytoma
- Disease ID
- Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT04047303 | Active, not recruiting | Phase 1 | CNS Penetration, PK and PD of Preoperative CC-90010 in Progressive/Recurrent Diffuse Astrocytoma, Anaplastic Astrocytoma and Glioblastoma | January 2, 2020 | May 30, 2024 |
| NCT03911388 | Active, not recruiting | Phase 1 | HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors | September 12, 2019 | September 1, 2026 |
| NCT03739372 | Active, not recruiting | N/A | Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan for Patients With High Grade Glioma | November 28, 2018 | January 1, 2027 |
| NCT01288235 | Active, not recruiting | Phase 2 | Proton Radiotherapy for Pediatric Brain Tumors Requiring Partial Brain Irradiation | February 2011 | September 2025 |
| NCT00080054 | Completed | Phase 1 | A Study of Motexafin Gadolinium and Temozolomide for the Treatment of Malignant Gliomas | ||
| NCT00154375 | Completed | Phase 3 | Study of Imatinib Mesylate in Combination With Hydroxyurea Versus Hydroxyurea Alone as an Oral Therapy in Patients With Temozolomide Resistant Progressive Glioblastoma | October 2004 | |
| NCT00165360 | Completed | Phase 2 | Prolonged Daily Temozolomide for Low-Grade Glioma | September 2001 | September 2009 |
| NCT00179803 | Completed | Phase 2 | Stem Cell Transplant for High Risk Central Nervous System (CNS) Tumors | March 1998 | September 2009 |
| NCT00335075 | Completed | Phase 3 | Efficacy and Safety of Temodal vs Semustine in Subjects With Recurrent Glioblastoma or Anaplastic Astrocytoma (Study P03644) | March 2, 2005 | February 23, 2006 |
| NCT04430842 | Completed | Phase 1 | Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S | July 20, 2020 | December 22, 2022 |
| NCT00392171 | Completed | Phase 2 | The Effects of Continuous 28-day (28/28) Temozolomide Chemotherapy in Subjects With Recurrent Malignant Glioma Who Have Failed the Conventional 5-day (5/28) Treatment (P04601) | June 9, 2006 | September 15, 2009 |
| NCT00575887 | Completed | Phase 2 | Efficacy of Protracted Temozolomide in Patients With Progressive High Grade Glioma | August 2006 | March 2009 |
| NCT00624728 | Completed | Phase 1/Phase 2 | Assessment of 18FLT PET-CT for Volume Definition of High-grade Gliomas (GLIO-TEP) | February 2008 | November 2011 |
| NCT03900689 | Completed | Social Determinants of Health in Glioblastoma Population | May 22, 2019 | March 27, 2022 | |
| NCT00705198 | Completed | Temozolomide All-Case-Registered Surveillance (Designated Drug Use Investigation)(Study P05062) | September 2006 | July 2016 | |
| NCT00723827 | Completed | Temodal (Temozolomide) Post Marketing Surveillance Protocol (Study P05557AM2) | March 2008 | September 2011 | |
| NCT00782626 | Completed | Phase 2 | Everolimus (RAD001) for Children With Chemotherapy-Refractory Progressive or Recurrent Low-Grade Gliomas | June 2009 | August 2012 |
| NCT00783393 | Completed | Phase 2 | SCH 52365 Phase II Clinical Study: A Study on the Efficacy and Safety of Monotherapy With SCH 52365 in Patients With First Relapsed Anaplastic Astrocytoma (Study P03745) | May 27, 2003 | June 17, 2005 |
| NCT00795457 | Completed | Early Phase 1 | Effects of Vaccinations With HLA-A2-Restricted Glioma Antigen-Peptides in Combination With Poly-ICLC for Adults With High-Risk WHO Grade II Astrocytomas and Oligo-Astrocytomas | January 2009 | July 2015 |
| NCT00874861 | Completed | Early Phase 1 | HLA-A2-Restricted Glioma Antigen-Peptides Vaccinations With Poly-ICLC for Recurrent WHO Grade II Gliomas | April 2009 | November 2013 |
| NCT00921167 | Completed | Phase 2 | A Study to Evaluate the Efficacy of Bevacizumab Plus Irinotecan in Recurrent Gliomas | June 2009 | December 2013 |
| NCT00994071 | Completed | Phase 1 | A Phase I Study of ABT-888, an Oral Inhibitor of Poly(ADP-ribose) Polymerase and Temozolomide in Children With Recurrent/Refractory CNS Tumors | September 22, 2009 | March 19, 2013 |
| NCT03722355 | Completed | Phase 3 | Hyperfractionated RT With BCNU Versus Conventional RT With BCNU for Supratentorial Malignant Glioma | November 9, 1990 | October 18, 2002 |
| NCT03538587 | Completed | N/A | Feasibility and Preliminary Efficacy of a Mindfulness-based Intervention for Children and Young Adults With High Grade or High-Risk Cancer and Their Caregivers | January 29, 2019 | September 13, 2022 |
| NCT01125800 | Completed | Phase 1/Phase 2 | A Phase I Dose Finding and Safety Study of Oral LDE225 in Children and a Phase II Portion to Assess Preliminary Efficacy in Recurrent or Refractory MB | February 2011 | October 2014 |
| NCT01331135 | Completed | Phase 1 | Aflac ST0901 CHOANOME - Sirolimus in Solid Tumors | April 2011 | August 9, 2017 |
| NCT03032484 | Completed | Phase 2 | TVB- 2640 in Combination With Bevacizumab in Patients With First Relapse of High Grade Astrocytoma | May 18, 2017 | April 5, 2021 |
| NCT02942264 | Completed | Phase 1/Phase 2 | Zotiraciclib (TG02) Plus Dose-Dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) Plus Temozolomide Versus Temozolomide Alone in Adults With Recurrent Anaplastic Astrocytoma and Glioblastoma | December 14, 2016 | August 26, 2020 |
| NCT02903784 | Completed | N/A | Neural Basis of Language Processing | September 2012 | September 2016 |
| NCT02747407 | Completed | Qualitative, Qualitative, and Functional Studies Over the First Year in Measuring Immune System Response During the First Year of Therapy in Patients With Brain Tumors | May 2016 | September 9, 2021 | |
| NCT02684058 | Completed | Phase 2 | Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Pediatric Patients With BRAF V600 Mutation Positive LGG or Relapsed or Refractory HGG Tumors | December 28, 2017 | April 28, 2023 |
| NCT02010606 | Completed | Phase 1 | Phase I Study of a Dendritic Cell Vaccine for Patients With Either Newly Diagnosed or Recurrent Glioblastoma | January 8, 2014 | July 10, 2021 |
| NCT02529072 | Completed | Phase 1 | Nivolumab With DC Vaccines for Recurrent Brain Tumors | January 2016 | December 30, 2019 |
| NCT02666066 | Completed | Radiomics for Prediction of Survival in GBM | January 2016 | July 2018 | |
| NCT00009035 | Completed | Natural History of Patients With Brain and Spinal Cord Tumors | January 22, 2001 | September 11, 2018 | |
| NCT00028158 | Completed | Phase 1/Phase 2 | Safety and Effectiveness Study of G207, a Tumor-Killing Virus, in Patients With Recurrent Brain Cancer | December 2001 | October 2003 |
| NCT00001148 | Completed | Detecting Malignant Brain Tumor Cells in the Bloodstream During Surgery to Remove the Tumor | October 1999 | January 2005 | |
| NCT06439420 | Not yet recruiting | Phase 2 | CBT-I in Primary Brain Tumor Patients: Phase IIc Randomized Feasibility Pilot Trial | July 1, 2024 | November 30, 2026 |
| NCT05513859 | Not yet recruiting | N/A | Investigational Imaging Technique During Brain Surgery | June 30, 2024 | June 23, 2025 |
| NCT05532969 | Not yet recruiting | Correlation Between Psychological Stress and Progression of Diffuse Astrocytoma Towards Secondary Glioma | December 20, 2022 | December 20, 2026 | |
| NCT05683808 | Not yet recruiting | Phase 2 | Venous Thromboembolism Prevention in Outpatients With Glioma | January 16, 2023 | December 31, 2024 |
| NCT06161974 | Not yet recruiting | Phase 2 | Study of Olutasidenib and Temozolomide in HGG | June 2024 | June 2035 |
| NCT06241391 | Not yet recruiting | N/A | Ga-68 Prostate Specific Membrane Antigen PET/CT in Gliomas | February 2024 | February 2025 |
| NCT06344130 | Not yet recruiting | Phase 1 | Hypofractionation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma | June 23, 2024 | December 31, 2027 |
| NCT02372409 | Recruiting | Phase 2 | Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumors | August 14, 2015 | August 31, 2030 |
| NCT04648462 | Recruiting | Proton Therapy Research Infrastructure- ProTRAIT- Neuro-oncology | January 1, 2018 | January 1, 2035 | |
| NCT05484622 | Recruiting | Phase 1 | Study of Vorasidenib and Pembrolizumab Combination in Recurrent or Progressive Enhancing IDH-1 Mutant Glioma | January 20, 2023 | August 30, 2027 |
| NCT05236036 | Recruiting | Phase 1 | Mycophenolate Mofetil in Combination With Standard of Care for the Treatment of Glioblastoma | August 8, 2022 | January 3, 2027 |
| NCT05345002 | Recruiting | Phase 2 | All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma | November 16, 2022 | June 1, 2027 |
| NCT05393258 | Recruiting | N/A | Temporally-modulated Pulsed Radiation Therapy (TMPRT) After Prior EBRT for Recurrent IDH-mutant Gliomas | June 28, 2022 | June 28, 2027 |
| NCT05624736 | Recruiting | Hierarchical Diagnosis for Adult Diffuse Glioma Based on Deep Learning | November 20, 2022 | May 1, 2025 | |
| NCT05561374 | Recruiting | Phase 1 | Study of Safety and Pharmacokinetic Properties of Oral OKN-007 in Patients With Recurrent High-Grade Glioma | April 17, 2023 | August 15, 2024 |
| NCT01649830 | Recruiting | Phase 3 | Efficacy of Post-radiation Adjuvant Temozolomide Chemotherapy in Residue Low-grade Glioma | July 2012 | August 2026 |
| NCT03796273 | Recruiting | Early Phase 1 | Ketoconazole Before Surgery in Treating Patients With Recurrent Glioma or Breast Cancer Brain Metastases | March 13, 2019 | September 2024 |
| NCT06108206 | Recruiting | N/A | Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma | January 30, 2024 | December 31, 2026 |
| NCT05686798 | Recruiting | Phase 1 | Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma. | November 29, 2022 | October 2024 |
| NCT03975829 | Recruiting | Phase 4 | Pediatric Long-Term Follow-up and Rollover Study | November 4, 2019 | May 29, 2026 |
| NCT04028479 | Recruiting | The Registry of Oncology Outcomes Associated With Testing and Treatment | May 5, 2021 | October 1, 2031 | |
| NCT01849952 | Recruiting | Evaluating the Expression Levels of MicroRNA-10b in Patients With Gliomas | February 28, 2020 | May 2024 | |
| NCT04135807 | Recruiting | Early Phase 1 | Implantable Microdevice In Primary Brain Tumors | March 3, 2020 | February 1, 2024 |
| NCT03152318 | Recruiting | Phase 1 | A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2 | July 18, 2017 | December 2025 |
| NCT01502605 | Terminated | Phase 1 | Phase I Study of Orally Administered Aminolevulinic Acid for Resection of Malignant Astrocytomas | September 2012 | June 2016 |
| NCT01351519 | Terminated | Phase 2 | A Study of Aminolevulinic Acid Used to Enhance Visualization and Surgical Removal of Brain Tumors | May 2011 | January 2015 |
| NCT01044966 | Terminated | Phase 1/Phase 2 | A Study of Intraventricular Liposomal Encapsulated Ara-C (DepoCyt) in Patients With Recurrent Glioblastoma | September 2009 | September 2014 |
| NCT00389090 | Terminated | Phase 2 | A Phase II Study of Temozolomide and O6-Benzylguanine (O6-BG) in Patients With Temozolomide-Resistant Anaplastic Glioma | October 2006 | February 2009 |
| NCT04327011 | Terminated | Phase 1 | A Continuation Protocol for Patients Previously Enrolled in a Study of Toca 511 | February 2011 | December 2019 |
| NCT00360828 | Terminated | Phase 2 | Phase II Study of Irinotecan HCI for Recurrent Anaplastic Astrocytomas, Mixed Malignant Gliomas, and Oligodendrogliomas | February 2006 | October 2010 |
| NCT00031538 | Terminated | Genetic Analysis of Brain Tumors | March 1, 2002 | April 29, 2015 | |
| NCT02764151 | Terminated | Phase 1 | First in Patient Study for PF-06840003 in Malignant Gliomas | September 9, 2016 | December 26, 2018 |
| NCT00591058 | Unknown status | Phase 1 | Safety and Dose-Finding Study of TM-601 in Adults With Recurrent Malignant Glioma | February 2008 | February 2010 |
| NCT01089244 | Unknown status | FET-PET for Diagnosis and Monitoring in Patients With Low Grade Glioma | June 2008 | December 2015 | |
| NCT03115164 | Unknown status | Astrocytoma / Desmoplastic Gamliogliomes (DIA / DIG) - Study of the French Cohort of the Last 20 Years : Clinical, Anatomopathological, Molecular and Radiological Charactersics | August 18, 2016 | August 18, 2017 | |
| NCT04970615 | Unknown status | Educating Brain Tumor Patients Using Patient-specific Actual-size Three-dimensional Printed Models | May 15, 2021 | December 15, 2023 | |
| NCT00683761 | Unknown status | Phase 1/Phase 2 | A Study of 131I-TM601 in Adults With Recurrent Malignant Glioma | August 2008 | April 2010 |
| NCT01579253 | Unknown status | Combined O-(2-[18F]Fluoroethyl)-L-tyrosine (FET) Positron Emission Tomography (PET) and Simultaneous Magnetic Resonance Imaging (MRI) Follow-up in Re-irradiated Recurrent Glioblastoma Patients | April 2012 | ||
| NCT02209428 | Unknown status | Phase 2 | A Prospective Cohort to Study the Effect of Temozolomide on IDH Mutational Low Grade Gliomas | June 2014 | May 2019 |
| NCT03649464 | Withdrawn | Phase 1/Phase 2 | Investigation of Oral OKN-007 in Recurrent High-grade Glioma Participants | August 2022 | August 2025 |
| NCT02976441 | Withdrawn | Early Phase 1 | Autologous Stem Cell Collection and Reinfusion in Newly Diagnosed High Grade Gliomas | January 2017 | February 2018 |
| NCT01117155 | Withdrawn | A Pilot Study Evaluating 18F-L-Thymidine (FLT) PET Imaging in Children With Gliomas | April 23, 2010 | October 22, 2012 |
- HPO Human Phenotype ID (Human Phenotype Ontology)
- HP:0009592
- OrphaNumber from OrphaNet (Orphanet)
- 94
- MeSH unique ID (MeSH (Medical Subject Headings))
- D001254