acute leukemia (Cancer)
Information
- Disease name
- acute leukemia
- Disease ID
- DOID:12603
- Description
- "A lymphoid leukemia that occurs when a hematopoietic stem cell undergoes malignant transformation into a primitive, undifferentiated cell with abnormal longevity producing large numbers of white blood cells to be produced and enter the blood stream." [url:http\://en.wikipedia.org/wiki/Acute_leukemia, url:http\://www.bloodjournal.org/content/bloodjournal/128/3/462.full.pdf, url:http\://www.merck.com/mmpe/sec11/ch142/ch142b.html]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT00048958 | Active, not recruiting | Cytogenetic Studies in Acute Leukemia and Multiple Myeloma | June 1984 | ||
| NCT03434730 | Active, not recruiting | Phase 2 | Tocilizumab for the Prevention of Graft Versus Host Disease After Cord Blood Transplantation | February 7, 2018 | February 7, 2025 |
| NCT02730299 | Active, not recruiting | Phase 3 | Stem Cell Transplantation With NiCord® (Omidubicel) vs Standard UCB in Patients With Leukemia, Lymphoma, and MDS | December 16, 2016 | February 18, 2025 |
| NCT00899223 | Active, not recruiting | Collecting and Storing Blood, Bone Marrow, and Other Samples From Patients With Acute Leukemia, Chronic Leukemia, or Myelodysplastic Syndromes | May 1996 | ||
| NCT03178617 | Active, not recruiting | N/A | High-Intensity Parent Intervention Program in Improving Learning and School Functioning in Latino Children With Acute Leukemia or Lymphoblastic Lymphoma | February 14, 2018 | December 15, 2024 |
| NCT02722668 | Active, not recruiting | Phase 2 | UCB Transplant for Hematological Diseases Using a Non Myeloablative Prep | May 15, 2017 | December 2029 |
| NCT04013685 | Active, not recruiting | Phase 1 | Precision-T: A Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies | November 21, 2019 | July 2026 |
| NCT03735797 | Active, not recruiting | Cancer Stem Cells in Acute Leukemia | July 12, 2017 | March 1, 2026 | |
| NCT05316701 | Active, not recruiting | Phase 3 | Precision-T: A Randomized Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies | June 21, 2022 | April 2027 |
| NCT04339101 | Active, not recruiting | Phase 2 | Itacitinib, Tacrolimus, and Sirolimus for the Prevention of GVHD in Patients With Acute Leukemia, Myelodysplastic Syndrome, or Myelofibrosis Undergoing Reduced Intensity Conditioning Donor Stem Cell Transplantation | November 11, 2020 | May 22, 2024 |
| NCT05320809 | Active, not recruiting | Phase 1 | Study of 3D189 in Patients With Hematologic Malignancies | August 1, 2022 | December 2024 |
| NCT04281199 | Active, not recruiting | Phase 1 | TBI Using IMRT (VMAT or Tomotherapy) for the Prevention of Pul Toxicities in Patients Undergoing Donor SCT | February 28, 2020 | December 30, 2024 |
| NCT03792256 | Active, not recruiting | Phase 1 | Palbociclib in Combination With Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LL) | April 11, 2019 | June 30, 2025 |
| NCT05974410 | Available | Expanded Access to Immunomodulatory AVM0703 for Solid Tumor and Blood Cancer Patients | |||
| NCT01496547 | Completed | Phase 2 | Sequential Intensive Chemotherapy Followed by RIC for Refractory and Relapse AML | January 2011 | June 30, 2018 |
| NCT01499147 | Completed | N/A | Fludarabine Based Conditioning for Allogeneic Transplantation for Advanced Hematologic Malignancies | February 2000 | May 2013 |
| NCT01502072 | Completed | Phase 2 | Respiratory Syncytial Virus - RSV Protocol | December 28, 2011 | February 1, 2020 |
| NCT01557686 | Completed | Early Phase 1 | Health Counseling and Exercise in Patients With Acute Leukemia - Pilot Study | May 2010 | February 2011 |
| NCT01660607 | Completed | Phase 1/Phase 2 | Phase 1-2 MAHCT w/ TCell Depleted Graft w/ Simultaneous Infusion Conventional and Regulatory T Cell | December 2011 | December 20, 2023 |
| NCT01661413 | Completed | Nausea and Vomiting in Children Receiving Chemotherapeautic Monotherapy | May 7, 2012 | October 31, 2015 | |
| NCT02440178 | Completed | Phase 2 | Micafungin Prophylaxis During 1st Induction Chemotherapy for De Novo Acute Leukemia | September 19, 2015 | June 1, 2017 |
| NCT03469921 | Completed | Unicentric Retrospective Analysis of a Cohort of 602 Young Adult and Adolescent Patients (AJA), Aged 15 to 30 Years, With Haematological Malignancies, and Managed Between 2000 and 2016 | January 1, 2000 | December 31, 2016 | |
| NCT03493906 | Completed | N/A | Patient Ambassador Support in Newly Diagnosed Patients With Acute Leukemia During Treatment | March 1, 2018 | September 1, 2019 |
| NCT03698656 | Completed | Effect on Patient Quality of Life of Taking Into Account the Spiritual Dimension in Nurse's Care for Haematologic Cancers. | October 10, 2018 | October 1, 2020 | |
| NCT03669172 | Completed | Phase 1/Phase 2 | Efectiveness of Donor IL-15-stimulated NK Cells Post Transplant Infusion in in Acute Leukemia | November 2, 2017 | July 6, 2021 |
| NCT00988013 | Completed | N/A | Intensity Modulated Total Marrow Irradiation (IM-TMI) for Advanced Hematologic Malignancies | September 2009 | February 2016 |
| NCT01020175 | Completed | Phase 3 | Peripheral Blood (PB) Versus Bone Marrow (BM) in Allogeneic Stem Cell Transplantation | January 1995 | December 2002 |
| NCT01036009 | Completed | Phase 2 | A Study of Withdrawal of Immunosuppression and Donor Lymphocyte Infusions Following Allogeneic Transplant for Pediatric Hematologic Malignancies | October 2009 | July 2015 |
| NCT01314599 | Completed | Phase 1 | Clinical Study of PM01183 in Patients With Acute Leukemia or Relapsed/Refractory Myelodysplastic Syndrome | May 2011 | July 2015 |
| NCT01321372 | Completed | An Observational Analysis of Voriconazole Therapeutic Drug Concentration Monitoring, Pharmacogenomics and Clinical Outcome Correlations in High-risk Hematology Patients | June 2007 | June 2011 | |
| NCT01336712 | Completed | Phase 2 | Total Body Irradiation/Fludarabine Based Ablative Haploidentical Transplant for Hematologic Diseases | April 2011 | July 2015 |
| NCT01362985 | Completed | Analysis of Data Collected in the European Group for Blood and Marrow Transplantation (EBMT) Registry for Off-Label Transplant Use of Plerixafor | July 2009 | July 2014 | |
| NCT01385891 | Completed | Phase 2/Phase 3 | Clove In The Treatment Of Relapsed Or Resistant Acute Leukemia In Children | August 2008 | February 2010 |
| NCT01404520 | Completed | N/A | Patient Activation, Counseling and Exercise - Acute Leukemia (PACE-AL) | June 2011 | May 2015 |
| NCT02823132 | Completed | Study of the Level of a Protein Which Could Predict the Development of a Fungal Infection in Patients With Acute Leukemia | |||
| NCT02930109 | Completed | Phase 1/Phase 2 | A Study of PTX-200 (Triciribine) Plus Cytarabine in Refractory or Relapsed Acute Leukemia | December 9, 2016 | March 4, 2024 |
| NCT00592046 | Completed | Phase 1 | A Phase I Trial of ZIO-101 in Hematologic Cancers | May 2005 | June 2008 |
| NCT03042676 | Completed | Electronic Database for the Follow up of the ATG_FamilyStudy | September 15, 2017 | June 30, 2018 | |
| NCT00701844 | Completed | N/A | Sharing Our Strength: A Research Study for Bone Marrow/Stem Cell Transplant Survivors | July 2007 | September 2011 |
| NCT03096782 | Completed | Phase 2 | Umbilical Cord Blood Transplant With Added Sugar and Chemotherapy and Radiation Therapy in Treating Patients With Leukemia or Lymphoma | October 13, 2017 | September 20, 2022 |
| NCT03128359 | Completed | Phase 2 | High Dose Cyclophosphamide, Tacrolimus, and Mycophenolate Mofetil in Preventing Graft Versus Host Disease in Patients With Hematological Malignancies Undergoing Myeloablative or Reduced Intensity Donor Stem Cell Transplant | May 30, 2017 | September 15, 2021 |
| NCT04409379 | Completed | Association Between Telomere Length and Cardiac Dysfunction | January 1, 2019 | May 1, 2020 | |
| NCT03232619 | Completed | Phase 1/Phase 2 | CD19-CART Treatment for ALL | August 1, 2018 | September 15, 2020 |
| NCT04182074 | Completed | Monitoring the Diagnosis and Management of Acute Leukaemia In Pregnancy Study. | November 22, 2019 | September 30, 2022 | |
| NCT03279900 | Completed | Hematotoxicity in Acute Lymphoblastic Leukemia Children in Maintenance Phase Therapy | October 2, 2017 | July 16, 2018 | |
| NCT03969082 | Completed | N/A | Evaluation of Bibliotherapy by Students and Patients With Cancer | March 9, 2019 | March 1, 2024 |
| NCT00823316 | Completed | Phase 1/Phase 2 | Safety and Efficacy Study of Umbilical Cord Blood-Drived Mesenchymal Stem Cells to Promote Engraftment of Unrelated Hematopoietic Stem Cell Transplantation | August 2008 | February 2010 |
| NCT03316456 | Completed | Gut Microbiota in Intestinal Barrier Damage in Acute Leukemia Patients Undergoing Inpatient Induction | August 22, 2017 | April 1, 2019 | |
| NCT03959241 | Completed | Phase 3 | TAC/MTX vs. TAC/MMF/PTCY for Prevention of Graft-versus-Host Disease and Microbiome and Immune Reconstitution Study (BMT CTN 1703/1801) | June 25, 2019 | September 19, 2022 |
| NCT01814488 | Completed | Phase 2 | A Phase II Study on Allogeneic Stem Cell Transplantation in Patients With Active Acute Leukemia | July 2013 | June 30, 2017 |
| NCT01855698 | Completed | PENELOPE Observational Study: Prophylaxis and Treatment of Arterial and Venous Thromboembolism | June 2013 | March 15, 2018 | |
| NCT01900509 | Completed | Phase 1 | Bendamustine Hydrochloride, Clofarabine, and Etoposide in Treating Younger Patients With Relapsed or Refractory Hematologic Malignancies | August 2013 | May 2016 |
| NCT02038361 | Completed | N/A | Implementation of Innovative Techniques in Routine Diagnosis of Childhood Acute Leukemia: Analysis of Genome and Transcriptome by Micro-array | February 4, 2014 | July 27, 2023 |
| NCT02169791 | Completed | Phase 2 | Nonmyeloablative Haploidentical Transplant Followed by MLN9708 | July 15, 2014 | July 28, 2020 |
| NCT02208037 | Completed | Phase 2 | Novel Approaches for Graft-versus-Host Disease Prevention Compared to Contemporary Controls (BMT CTN 1203) | August 2014 | October 2017 |
| NCT02246907 | Completed | N/A | Exercise and Quality of Life in Leukemia Patients | January 2014 | December 2015 |
| NCT04904211 | Completed | N/A | Feasiblity and Safety of Home-based Intensive Chemotherapy | January 2017 | September 2020 |
| NCT02345850 | Completed | Phase 3 | Calcineurin Inhibitor-Free Interventions BMT CTN 1301 for Prevention of Graft-versus-Host Disease (BMT CTN 1301) | August 2015 | October 5, 2020 |
| NCT02353559 | Completed | N/A | Emotion And Symptom-focused Engagement (EASE): An Intervention for Individuals With Acute Leukemia | March 2015 | November 2016 |
| NCT00273936 | Completed | Phase 1 | Trial of AVN-944 in Patients With Advanced Hematologic Malignancies | January 2006 | |
| NCT02445378 | Completed | N/A | Aromatherapy and Essential Oils in Improving Insomnia and Other Symptoms in Patients With Newly Diagnosed Acute Leukemia Undergoing Chemotherapy | December 28, 2014 | November 5, 2016 |
| NCT02451592 | Completed | Fungemia in Hematologic Malignancies | January 2011 | January 2016 | |
| NCT02487069 | Completed | N/A | Allo-HSCT With Alternative Donor in Treatment of Hematologic Malignancy | June 2015 | February 29, 2020 |
| NCT02580071 | Completed | N/A | Chinese Herbal Medicine for Immune Reconstitution Following HSCT in Acute Leukemia Patients | October 2015 | August 2017 |
| NCT00520130 | Completed | Phase 1/Phase 2 | Chemotherapy and Unrelated Donor Stem Cell Transplantation for Patients With Cancers of the Blood and Immune System | October 30, 2007 | December 31, 2018 |
| NCT02693899 | Completed | Prospective Study on the Feasibility of Plasma FLT3-Ligand Assay to Achieve a First Estimate of Its Prognostic Value on the Outcome of Patients Treated Intensively for Acute Leukemia | May 27, 2016 | December 11, 2018 | |
| NCT04597086 | Completed | N/A | Bright White Light Therapy for the Improvement of Sleep, Fatigue, Distress, Depression, and Anxiety in Hospitalized Leukemia Patients | September 14, 2020 | January 13, 2023 |
| NCT04552912 | Completed | N/A | Physical Activity to Improve Patient Reported Outcomes for Adults With Acute Leukemia | January 15, 2021 | September 15, 2022 |
| NCT01728402 | Enrolling by invitation | Pathogenesis of Hematologic Malignancies | September 2008 | ||
| NCT05809050 | Not yet recruiting | Study of miRNA-155 in Acute Leukemia | April 2023 | April 2024 | |
| NCT06058858 | Not yet recruiting | Incidence and Risks Factors of CMV Reactivation in Patients Receiving of CAR-T Cells for Acute Leukemia and Lymphoma Relapse, a Cohort Study Analysis | October 1, 2023 | January 1, 2025 | |
| NCT06207123 | Not yet recruiting | Phase 1/Phase 2 | A Study to Investigate LP-118, Ponatinib, Vincristine and Dexamethasone in Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LBL) | April 1, 2025 | December 1, 2026 |
| NCT06058572 | Not yet recruiting | Phase 2 | Effect of Rifaximin on Gut Bacterial Flora Post Stem Cell Transplant in Patients With Acute Leukemia | October 15, 2023 | October 15, 2026 |
| NCT05587088 | Not yet recruiting | Phase 1/Phase 2 | Evaluation of the Safety and Efficacy of Esperanza Extract (PA001) | December 15, 2022 | June 15, 2023 |
| NCT06265584 | Not yet recruiting | Phase 2 | Trial of 2 Step ATG for Prevention of Acute GVHD Post Allogeneic Stem Cell Transplant | June 28, 2024 | May 2028 |
| NCT06279494 | Not yet recruiting | Phase 1/Phase 2 | Sirolimus+Abatacept+Mycophenolate Mofetil for Prophylaxis of aGVHD in Patients Receiving Haplo-HSCT Who Are Intolerant to Calcineurin Inhibitors | March 2024 | March 2025 |
| NCT06421155 | Not yet recruiting | N/A | Brain MRF in Children, Adolescents and Young Adults With Acute Leukemia | July 31, 2024 | November 14, 2028 |
| NCT04451200 | Not yet recruiting | Phase 2 | Sequential and Personalized PK-guided Busulfan Administration in the Frame of the Conditiong Regimen for Allo-HSCT in Patients With Malignant Hemopathies Ineligible for the Standard Myeloablative Conditioning | November 2020 | December 2028 |
| NCT05902416 | Not yet recruiting | Clinical Registration Study of Haplo-HSCT for Elderly Patients With Acute Leukemia/ Myelodysplastic Syndrome | June 2023 | December 2024 | |
| NCT06026839 | Not yet recruiting | Longitudinal Study on the QoL of Pediatric Patients After HSCT and Its Influencing Factors | October 30, 2023 | December 31, 2024 | |
| NCT06315309 | Not yet recruiting | Phase 2 | Trial of 2 Step ATG for Acute GVHD Prevention Post Myeloablative Allogeneic Stem Cell Transplant | June 29, 2024 | February 2027 |
| NCT05654766 | Not yet recruiting | Assesment of the Functional Activity of Platelets for the Differential Diagnosis of Thrombocytopathies | January 2, 2023 | December 31, 2024 | |
| NCT06356922 | Not yet recruiting | Phase 1/Phase 2 | Study Assessing RLT Using [177Lu]Lu-PentixaTher for Relapsed/Refractory CXCR4+ Acute Leukemia. | May 15, 2024 | May 15, 2027 |
| NCT05589896 | Recruiting | Phase 1/Phase 2 | A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased Donor Bone Marrow Transplantation for Patients With Hematologic Malignancies | March 30, 2024 | August 2025 |
| NCT02356159 | Recruiting | Phase 1/Phase 2 | Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation | September 24, 2015 | December 1, 2024 |
| NCT02677064 | Recruiting | Identify Barriers to Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Newly Diagnosed and Relapsed Acute Leukemia | February 2016 | February 2025 | |
| NCT03016806 | Recruiting | Phase 1 | Umbilical Cord Blood Transplantation From Unrelated Donors | June 2015 | June 2026 |
| NCT03050268 | Recruiting | Familial Investigations of Childhood Cancer Predisposition | April 6, 2017 | March 31, 2037 | |
| NCT03314974 | Recruiting | Phase 2 | Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders | March 30, 2018 | November 10, 2025 |
| NCT03412409 | Recruiting | Phase 2 | RIC Regimen for Elderly or High Comorbidity Burden Patients Receiving Haplo-HSCT | February 1, 2018 | September 1, 2025 |
| NCT03756675 | Recruiting | Haploidentical Peripheral Blood Stem Cell Transplantation for Acute Leukemia | November 1, 2018 | November 1, 2025 | |
| NCT03779854 | Recruiting | Phase 2 | Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant | August 29, 2019 | December 31, 2025 |
| NCT03810196 | Recruiting | N/A | CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post TCRαβ/CD19 Depleted HSCT | March 1, 2019 | January 2026 |
| NCT03959007 | Recruiting | N/A | Impact of Supportive Care on the Experience of Hospitalization of Patients Staying in the Protected Area of the Department of Blood Diseases | March 15, 2019 | March 2024 |
| NCT03970096 | Recruiting | Phase 2 | Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia or Myelodysplastic Syndrome (MDS) | November 19, 2019 | December 31, 2028 |
| NCT04099966 | Recruiting | Phase 2 | AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion | April 1, 2021 | December 31, 2026 |
| NCT04157569 | Recruiting | CtDNA After Chemotherapy in Elderly Patients With Acute Leukemia | November 5, 2019 | December 31, 2029 | |
| NCT04187105 | Recruiting | Phase 2 | BMT-06: Study of Intensity Modulated Total Marrow Irradiation (IM-TMI) | January 27, 2020 | November 2024 |
| NCT04195633 | Recruiting | Phase 2 | Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies | January 25, 2021 | December 31, 2026 |
| NCT04202835 | Recruiting | Phase 2 | ATG Plus PTCy vs ATG for CGVHD Prophylaxis | October 13, 2020 | December 31, 2024 |
| NCT04224974 | Recruiting | N/A | Emotion and Symptom-Focused Engagement Trial for Individuals With Acute Leukemia | January 6, 2022 | December 31, 2024 |
| NCT04767152 | Recruiting | N/A | Evaluation of Brain Changes in ALL Patients on Therapy | February 16, 2021 | January 21, 2026 |
| NCT04767165 | Recruiting | N/A | Quantitative MRI of Bone Marrow in Patients With Acute Lymphoblastic Leukemia | February 22, 2021 | March 21, 2026 |
| NCT04899882 | Recruiting | N/A | Physical Fitness Impact of Early Physiotherapy Intervention With a Standardized Exercise Therapy Program in Adult Patients Receiving Intensive Induction Chemotherapy for Treatment of Acute Leukemia During Extended Hospitalization. | January 5, 2022 | March 5, 2025 |
| NCT04904588 | Recruiting | Phase 2 | HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide | September 30, 2021 | July 2024 |
| NCT05035615 | Recruiting | Evaluation of the BD OneFlow Acute Leukemia Panel on the BD FACSLyric Flow Cytometer | November 2, 2021 | June 30, 2024 | |
| NCT05053100 | Recruiting | Understanding the Risk of Blood Clots and Bleeding in Patients With Hematological Malignancies, HAT Study | August 17, 2021 | August 18, 2025 | |
| NCT05071482 | Recruiting | Phase 4 | Flumatinib Versus Imatinib Combined With Chemotherapy for de Novo Ph+ ALL | September 16, 2021 | October 30, 2025 |
| NCT05088356 | Recruiting | Phase 1 | Reduced Intensity Allogeneic HCT in Advanced Hematologic Malignancies w/T-Cell Depleted Graft | September 7, 2021 | December 2025 |
| NCT05120570 | Recruiting | Phase 1/Phase 2 | PTCy + Sirolimus/VIC-1911 as GVHD Prophylaxis in Myeloablative PBSC Transplantation | March 17, 2022 | March 31, 2028 |
| NCT05298930 | Recruiting | N/A | Feasibility Study to Assess an Adapted Physical Activity Program in Children, Adolescents and Young Adults Requiring Hematopoietic Stem Cell Transplantation | May 25, 2022 | July 2024 |
| NCT05328258 | Recruiting | Phase 3 | Use of GnRHa During Chemotherapy for Fertility Protection | March 31, 2023 | January 31, 2032 |
| NCT05335226 | Recruiting | N/A | Combined Haploidentical and Umbilical Cord Blood Allogeneic Stem Cell Transplantation in Patients With Acute Leukemia | June 6, 2022 | March 1, 2024 |
| NCT05406817 | Recruiting | Phase 1 | Study of Radiolabeled Revumenib in Adults With Acute Leukemia | August 5, 2022 | September 2024 |
| NCT05428176 | Recruiting | N/A | A High Intensity Electronic Health Intervention for the Reduction of Learning Disparities in Childhood Cancer Survivors | February 16, 2023 | June 30, 2027 |
| NCT05521204 | Recruiting | Phase 2 | Olverembatinib for FGFR1-rearranged Neoplasms | September 1, 2022 | August 31, 2027 |
| NCT05601895 | Recruiting | The Gut Microbiome in FLT3- AL Undergoing Allo-HSCT With Or Without Sorafenib Maintenance | October 1, 2022 | December 31, 2024 | |
| NCT05634915 | Recruiting | Phase 4 | Clinical Study of rATG Individualized Administration in Haploidentical Hematopoietic Stem Cell Transplantation | December 20, 2022 | May 1, 2025 |
| NCT05735717 | Recruiting | Phase 2 | MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies | May 11, 2023 | November 30, 2030 |
| NCT05739630 | Recruiting | Phase 2/Phase 3 | M-PTCy vs BuCy in Haploidentical HSCT for Acute Leukemia | January 1, 2023 | January 31, 2025 |
| NCT06001385 | Recruiting | Phase 2 | HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced Dose Post Transplantation Cyclophosphamide GvHD Prophylaxis | December 8, 2023 | June 30, 2026 |
| NCT06001788 | Recruiting | Phase 1 | Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia | February 22, 2024 | August 2027 |
| NCT06076226 | Recruiting | A Retrospective Study on the Relationship Between Donor Leukocyte Telomere Length and Prognosis of Acute Leukemia Patients Treated With Allogeneic Hematopoietic Stem Cell Transplantation | January 1, 2015 | December 1, 2026 | |
| NCT06211166 | Recruiting | Assessment of Measurable Residual Disease in Allo-HSCT Using Digital Polymerase Chain Reaction | January 8, 2024 | December 31, 2027 | |
| NCT01709396 | Suspended | Phase 2 | ED-TBI Followed By Allogeneic Stem Cell Transplantation For The Treatment Of Refractory AML And Advanced MDS | January 2012 | January 2018 |
| NCT04151706 | Suspended | Phase 2 | CD34 Selected Allogeneic HCT w/ Myeloablative Conditioning Plus CD8+ Memory TCell Infusion in MDS, AL and CML | February 27, 2020 | February 2026 |
| NCT04328714 | Suspended | Phase 1 | Interferon γ-Primed Mesenchymal Stromal Cells as Prophylaxis for Acute Graft v Host Disease | December 2, 2021 | August 2024 |
| NCT03672851 | Terminated | Phase 1 | Study Evaluating Safety and Efficacy of CAR-T Cells Targeting CD123 in Patients With Acute Leukemia | April 17, 2019 | July 31, 2019 |
| NCT01214655 | Terminated | Phase 1 | A Study for Patients With Acute Leukemia | June 2008 | February 2011 |
| NCT01615042 | Terminated | Phase 1 | Phase I Study of Lenalidomide in Patients With Acute Leukemia | August 2012 | May 2017 |
| NCT01598025 | Terminated | N/A | Biparental HLA Haplotype Disparate T-cell Depleted Transplants for Patients Lacking an HLACompatible Donor | May 2, 2012 | October 16, 2017 |
| NCT03588936 | Terminated | Phase 1 | Nivolumab and Tocilizumab for Relapsed Hematological Malignancy Post-allogeneic Transplant | September 14, 2018 | July 15, 2020 |
| NCT00852709 | Terminated | Phase 1 | Phase I Dose-Escalation Trial of Clofarabine Followed by Escalating Doses of Fractionated Cyclophosphamide in Children With Relapsed or Refractory Acute Leukemias | September 1, 2007 | November 20, 2009 |
| NCT02877082 | Terminated | Phase 2 | Tacrolimus, Bortezomib, & Thymoglobulin in Preventing Low Toxicity GVHD in Donor Blood Stem Cell Transplant Patients | September 2016 | July 2017 |
| NCT03176277 | Terminated | Phase 1/Phase 2 | A Study of ONO-7475 in Patients With Acute Leukemias | June 26, 2017 | January 20, 2023 |
| NCT01624701 | Terminated | Phase 1/Phase 2 | Clinical Ex Vivo Expansion of Human Umbilical Cord Blood Stem and Progenitor Cells | March 2012 | July 2016 |
| NCT01350258 | Terminated | Phase 1/Phase 2 | Bone Marrow Transplant Using a Reduced Intensity Regimen That is Given in Two Steps | April 2011 | August 2012 |
| NCT03298321 | Unknown status | Action of the Vidaza on the Atrial Fibrillation | December 20, 2018 | December 20, 2021 | |
| NCT02344953 | Unknown status | Prospective and Retrospective Cohort Study of New Prognostic Factors With Peripheral Blood and Bone Marrow Evaluation at the Time of Diagnosis and During Treatment or Thereafter in Acute Leukemia (Acute Leukemia HSCT Cohort) | January 2011 | January 2021 | |
| NCT03297528 | Unknown status | Phase 2 | Chemotherapy and DLI for Prevention of Second Relapse in Patients With Relapsed Acute Leukemia After Allotransplant | March 1, 2017 | October 1, 2021 |
| NCT04084327 | Unknown status | Immunophenotyping of Acute b Cell Lymphoblstic Leukemia | September 1, 2019 | December 1, 2022 | |
| NCT02320656 | Unknown status | N/A | Predictive Clinical and Biological Parameters in Acute Leukemia, Myelodysplastic Syndromes and Myeloproliferative Disorders-HEMATO-BIO-IPC-2013-015 | May 2014 | May 2024 |
| NCT03278145 | Unknown status | Dependence Receptors and Leukemia | November 2017 | November 2019 | |
| NCT01239485 | Unknown status | Phase 1 | Study of IRNEA (Irinotecan, Etoposide, Cytarabine) for Refractory or Relapsed Acute Leukemia in Children and Adolescents | November 2010 | December 2013 |
| NCT01603290 | Unknown status | Change of Fatigue and Physical Fitness in Hospitalized Hematology Patients | December 2011 | December 2013 | |
| NCT01509300 | Unknown status | Phase 1/Phase 2 | HLA-haploidentical Hematopoietic Stem Cell Transplantation for Children and Adolescents With Acute Leukemia, Myelodysplastic Syndrome and Solid Tumors | January 2012 | March 2014 |
| NCT03267485 | Unknown status | Expression of TET1 Gene in Acute Leukaemia | November 1, 2017 | December 2018 | |
| NCT04298502 | Unknown status | The Molecular Mechanism of CMV-driven NKG2C+NK Cell Expansion in Human | January 1, 2020 | December 31, 2021 | |
| NCT02752243 | Unknown status | Phase 1/Phase 2 | CIK-Cells in Relapsing Patients With Acute Leukemia or Myelodysplastic Syndromes After SCT. | March 2016 | March 2024 |
| NCT01956630 | Unknown status | Phase 1/Phase 2 | Clinical Study of DC Plus CIK for Patients With Relapse Acute Leukemia After Allo-HSCT | September 2013 | December 2016 |
| NCT01800643 | Unknown status | Phase 2/Phase 3 | Evaluation of Plasmatic Levels of Busulfan in Patients Undergoing Hematopoietic Stem Cell Transplantation | March 2010 | December 2014 |
| NCT02344966 | Unknown status | Cohort Study of New Prognostic Factors With Peripheral Blood and Bone Marrow Evaluation at the Time of Diagnosis and During Treatment or Thereafter in Acute Leukemia | June 2011 | February 2021 | |
| NCT01498016 | Unknown status | Phase 2 | Pharmacokinetic Study of Busulfan in Allogeneic Stem Cell Transplantation in Adult Patients With Acute Leukemia | November 2011 | June 2022 |
| NCT04969601 | Unknown status | Phase 1/Phase 2 | Anti-Covid-19 Vaccine in Children With Acute Leukemia and Their Siblings | September 29, 2021 | March 29, 2023 |
| NCT01472055 | Unknown status | Phase 2 | Pharmacokinetic Study of Fludarabine in Pediatric Hematopoietic Stem Cell Transplantation | October 2011 | September 2014 |
| NCT03595800 | Unknown status | Phase 3 | Extension of a Study of Allogeneic Hematopoietic Stem Cell Transplantation From One Haplotype Mismatch Related Donor or From an Unrelated Donor to Younger Patients Eligible for Reduced-intensity Conditioning Regimen | September 19, 2017 | February 2, 2022 |
| NCT03408223 | Unknown status | N/A | Total Marrow and Lymphoid Irradiation and Chemotherapy for High-Risk Acute Leukemia | March 2014 | December 2022 |
| NCT03743909 | Unknown status | Expression of Aberrant CD Markers in Acute Leukemia:Retrospective Study in South Egypt Cancer Institute | January 1, 2019 | April 2021 | |
| NCT01695512 | Unknown status | Diagnostic Study of Combined Biomnarker Testing in Bronchoalveolar Lavage Samples of Immunocompromised Patients | August 2012 | December 2020 | |
| NCT03408210 | Unknown status | N/A | Total Marrow and Lymphoid Irradiation and Chemotherapy for Myelodysplastic Syndrome or Acute Leukemia | March 2014 | August 2022 |
| NCT03364257 | Unknown status | iDTECT Blood Performance for the Identification of Viral or Bacterial Pathogens in Febrile Neutropenic Patients | May 18, 2018 | May 31, 2019 | |
| NCT04551235 | Unknown status | Establishing Automatic Method of Counting and Classify Bone Marrow and Peripheral Blood Cells | August 28, 2020 | December 31, 2023 | |
| NCT02822326 | Unknown status | Phase 1 | Phase I Study of CD19-CAR-T2 Cells for Patients With Chemotherapy Resistant or Refractory CD19+ Acute Leukemia | January 2016 | September 2019 |
| NCT04674345 | Unknown status | Phase 2/Phase 3 | Sorafenib Maintenance for Prophylaxis of Leukemia Relapse in Allo-HSCT Recipients With FLT3 Negative Acute Leukemia | December 15, 2020 | December 31, 2023 |
| NCT03739606 | Withdrawn | Phase 2 | Flotetuzumab in Treating Patients With Recurrent or Refractory CD123 Positive Blood Cancer | October 20, 2020 | October 20, 2020 |
| NCT04331483 | Withdrawn | N/A | A Study to Assess a Physical Activity Program in Children, Adolescents and Young Adults Requiring Hematopoietic Stem Cell Allografts | December 8, 2018 | September 2023 |
| NCT05170828 | Withdrawn | Phase 1 | Cryopreserved MMUD BM With PTCy for Hematologic Malignancies | September 2022 | November 2024 |
| NCT03138395 | Withdrawn | iCare3: Monitoring Circulating Cancer DNA After Chemotherapy in MDS and AML | September 15, 2017 | August 15, 2019 |
- Disase is a (Disease Ontology)
- DOID:1037
- Cross Reference ID (Disease Ontology)
- ICD10CM:C95.00
- Cross Reference ID (Disease Ontology)
- ICD9CM:208.0
- Cross Reference ID (Disease Ontology)
- ICDO:9801/3
- Cross Reference ID (Disease Ontology)
- MIM:308960
- Cross Reference ID (Disease Ontology)
- NCI:C9300
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:24072005
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0085669
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C1378511
- Exact Synonym (Disease Ontology)
- Stem cell leukaemia
- Exact Synonym (Disease Ontology)
- Stem cell Leukemia
- HPO Human Phenotype ID (Human Phenotype Ontology)
- HP:0002488