colorectal carcinoma (Cancer)
Information
- Disease name
- colorectal carcinoma
- Disease ID
- DOID:0080199
- Description
- "A colorectal cancer that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa." [url:https\://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&version=16.12d&ns=NCI_Thesaurus&code=C4978]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT04868773 | Active, not recruiting | Phase 1 | Study of Cabozantinib Plus TAS102 in mCRC as Salvage Therapy | July 16, 2021 | February 2025 |
| NCT03287453 | Active, not recruiting | N/A | Educational Intervention - Improving Knowledge and Screening Rates for Colorectal Cancer | April 8, 2017 | December 31, 2024 |
| NCT03267524 | Active, not recruiting | N/A | Walking for Recovery From Surgery in Improving Quality of Life in Older Adults With Lung or Gastrointestinal Cancer and Their Family Caregivers | November 9, 2017 | November 28, 2024 |
| NCT04281667 | Active, not recruiting | Phase 4 | Mechanical Bowel Preparation and Oral Antibiotics Versus Mechanical Bowel Preparation Only Prior Rectal Surgery | March 18, 2020 | October 10, 2027 |
| NCT03752398 | Active, not recruiting | Phase 1 | A Study of XmAb®23104 in Subjects With Selected Advanced Solid Tumors (DUET-3) | May 1, 2019 | September 2025 |
| NCT03164486 | Active, not recruiting | Early Phase 1 | First-in-Human Positron Emission Tomography Study Using the 18F-αvβ6-Binding-Peptide | November 2016 | December 2024 |
| NCT00199862 | Active, not recruiting | N/A | Safety Study of Radio-labeled huA33 Antibody in Colorectal Cancer | February 2004 | June 2027 |
| NCT04833387 | Active, not recruiting | Phase 2 | PD-1 Antibody Following Preoperative Chemoradiotherapy for Locally Advanced pMMR/MSS Rectal Cancer | January 1, 2021 | December 31, 2026 |
| NCT04890054 | Active, not recruiting | N/A | Screening More Patients for Colorectal Cancer Through Adapting and Refining Targeted Evidence-Based Interventions in Rural Settings, SMARTER CRC | May 14, 2021 | August 31, 2024 |
| NCT03151564 | Active, not recruiting | N/A | Lesion Detection Assessment in the Liver: Standard vs Low Radiation Dose Using Varied Post-Processing Techniques | May 9, 2017 | April 30, 2025 |
| NCT02863107 | Active, not recruiting | Young-Onset Colorectal Cancer | June 7, 2012 | August 31, 2030 | |
| NCT03732781 | Active, not recruiting | Phase 1/Phase 2 | Study of Radspherin® in Colorectal Carcinoma Subjects With Peritoneal Carcinomatosis Treated With HIPEC | May 27, 2020 | February 2025 |
| NCT02465060 | Active, not recruiting | Phase 2 | Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial) | August 17, 2015 | December 31, 2025 |
| NCT02408406 | Active, not recruiting | N/A | PatientCareAnywhere Internet-Based Software in Improving Communication and Education in Patients With Cancer and Their Healthcare Providers | July 7, 2015 | June 4, 2024 |
| NCT03377361 | Active, not recruiting | Phase 1/Phase 2 | An Investigational Immuno-therapy Study Of Nivolumab In Combination With Trametinib With Or Without Ipilimumab In Participants With Previously Treated Cancer of the Colon or Rectum That Has Spread | February 1, 2018 | March 11, 2024 |
| NCT02009449 | Active, not recruiting | Phase 1 | A Phase 1 Study of Pegilodecakin (LY3500518) in Participants With Advanced Solid Tumors | November 15, 2013 | August 25, 2024 |
| NCT04905082 | Active, not recruiting | N/A | HOPE-Genomics Intervention for the Improvement of Cancer Patient Knowledge of Genomics | December 30, 2021 | June 30, 2024 |
| NCT00785122 | Completed | Phase 1/Phase 2 | IMA910 Plus GM-CSF With Low-dose Cyclophosphamide Pre-treatment in Advanced Colorectal Carcinoma Patients Following a Successful 12 Week First-line Treatment With Oxaliplatin-based Chemotherapy (IMA910-101) | June 2008 | May 2013 |
| NCT00828984 | Completed | Phase 2 | Macrogol 3350-based Oral Osmotic Laxative in Preventing Cancer in Patients at Risk of Colorectal Cancer | October 2009 | October 2014 |
| NCT00862784 | Completed | Phase 2 | A Study of IMC-1121B (Ramucirumab) in Colorectal Cancer | April 2009 | August 2011 |
| NCT01139138 | Completed | Phase 1/Phase 2 | Safety Study of the Combination of Panitumumab, Irinotecan and Everolimus in the Treatment of Advanced Colorectal Cancer | June 2010 | June 2017 |
| NCT01151007 | Completed | KRAS Mutation and Incidence of the Colorectal Carcinoma in Martinique Between 2007 and 2009 | July 2011 | December 2011 | |
| NCT01175317 | Completed | Phase 4 | Improvement of Fluid Balance in Patients Undergoing Surgery of the Colon and Rectum | April 2010 | October 2013 |
| NCT01210313 | Completed | Physical Activity for Reduction of Recurrence Rate After Adjuvant Chemotherapy for Localised Colorectal Carcinoma | October 2010 | April 2013 | |
| NCT01286662 | Completed | A Cohort Study of Patients Treated With Brachytherapy for Selected Desmoid Patients in Gardner Syndrome | January 1978 | December 2010 | |
| NCT01286818 | Completed | Phase 1 | A Study of Irinotecan, Levofolinate, and 5-Fluorouracil (FOLFIRI) Plus Ramucirumab (IMC-1121B) | February 2011 | March 2012 |
| NCT01324284 | Completed | Phase 3 | Comparative Study of Lubiprostone and PEG Preparation Versus Conventional PEG Preparation for Colonoscopy | March 2011 | June 2011 |
| NCT01394939 | Completed | Phase 1/Phase 2 | Recombinant Vaccinia Virus Administered Intravenously in Patients With Metastatic, Refractory Colorectal Carcinoma | January 2012 | October 2015 |
| NCT01469611 | Completed | Phase 1 | A Trial of JX-594 in Refractory Colorectal Carcinoma | July 2010 | January 2015 |
| NCT01486251 | Completed | N/A | Assessment of Tumor Vascular Effects of Axitinib With Dynamic Ultrasonography in Patients With Metastatic Colorectal Cancer | September 2011 | September 2014 |
| NCT00040599 | Completed | Phase 1/Phase 2 | Safety Study of 90Y-hMN14 to Treat Colorectal Cancer | January 2000 | January 2004 |
| NCT00041652 | Completed | Phase 1/Phase 2 | Safety Study of hMN14 to Treat Either Colorectal or Breast Cancer | February 2000 | June 2003 |
| NCT00051987 | Completed | Phase 2 | Phase 2b Study of VELCADE Alone and VELCADE Plus Irinotecan in Patients With Relapsed or Refractory Colorectal Carcinoma | December 2002 | |
| NCT00107861 | Completed | Phase 1/Phase 2 | Interferon-Beta Gene Transfer (Ad.hIFN-β) as Treatment for Refractory Colorectal Carcinoma With Liver Metastases | May 2005 | September 2006 |
| NCT00176774 | Completed | Phase 2 | Irinotecan, 5-Fluorouracil, and Leucovorin in Colorectal Carcinoma | February 2001 | April 2004 |
| NCT00179348 | Completed | N/A | Yoga-Based Rehabilitation Program in Reducing Physical and Emotional Side Effects in Patients With Cancer | February 8, 2001 | July 20, 2016 |
| NCT00272051 | Completed | Phase 3 | XENOX - Evaluation of the Efficacy of Xaliproden in Reducing the Neurotoxicity of the Oxaliplatin + 5-FU/LV Chemotherapy | July 2002 | May 2004 |
| NCT00305188 | Completed | Phase 3 | Evaluation of the Efficacy of Xaliproden (SR57746A) in Preventing the Neurotoxicity of Oxaliplatin / 5FU/LV Chemotherapy. | December 2005 | October 2009 |
| NCT00362102 | Completed | Phase 2 | A Phase II Study of Cetuximab Plus Irinotecan in Patients With EGFR-detectable Metastatic Colorectal Carcinoma | October 2005 | July 2006 |
| NCT00405587 | Completed | Phase 1 | Safety Study of PLX4032 in Patients With Solid Tumors | November 2006 | February 2016 |
| NCT00437268 | Completed | Phase 2 | A Study of Irinotecan Plus Cetuximab With or Without Enzastaurin in Participants With Colorectal Cancer | March 2007 | May 2009 |
| NCT00478634 | Completed | Phase 1 | A Phase 1 Study Investigating the Combination of RAD001, Cetuximab and Irinotecan as Second-line Therapy After FOLFOX (or XELOX) Plus Bevacizumab in Patients With Metastatic Colorectal Cancer | May 2007 | September 2009 |
| NCT00485316 | Completed | Phase 3 | Laparoscopic Assisted Versus Open Resection for Colorectal Carcinoma | September 1993 | October 2008 |
| NCT00582660 | Completed | Phase 2 | Evaluation of Surgically Resected Colorectal Adenomas and Carcinomas After 7 Days Pretreatment With Celecoxib | December 2001 | June 2008 |
| NCT00588549 | Completed | Utility of PET In the Pre-Operative Assessment of Patients With Hepatic Colorectal Metastases | July 1998 | March 2009 | |
| NCT00704600 | Completed | Phase 1/Phase 2 | Nelfinavir, a Phase I/Phase II Rectal Cancer Study | September 2008 | July 2013 |
| NCT00724503 | Completed | N/A | FOLFOX Plus SIR-SPHERES MICROSPHERES Versus FOLFOX Alone in Patients With Liver Mets From Primary Colorectal Cancer | August 2006 | May 2015 |
| NCT01640522 | Completed | N/A | Comprehensive Electronic Cancer Support System for the Treatment of Cancer Related Symptoms | January 2008 | December 2014 |
| NCT01671592 | Completed | Phase 1 | Safety of Labeled Dendritic Cell (DC) Vaccines and Feasibility of Tracking by Magnetic Resonance Imaging (MRI) | January 2013 | April 2014 |
| NCT01675128 | Completed | Phase 1/Phase 2 | ISIS 183750 With Irinotecan for Advanced Solid Tumors or Colorectal Cancer | August 2012 | December 2015 |
| NCT01830621 | Completed | Phase 3 | BBI608 and Best Supportive Care vs Placebo and Best Supportive Care in Pretreated Advanced Colorectal Carcinoma | May 10, 2013 | May 16, 2016 |
| NCT02009774 | Completed | Accuracy of the Optical Diagnosis of Small Colonic Polyps Using the Nice Classification | January 2014 | May 2015 | |
| NCT02218801 | Completed | A Prospective Colorectal Liver Metastasis Database With an Integrated Quality Assurance Program | May 2015 | February 2021 | |
| NCT02248805 | Completed | Phase 1 | Phase 1 Study of MGD007 in Relapsed/Refractory Metastatic Colorectal Carcinoma | October 2014 | July 2, 2018 |
| NCT02254486 | Completed | Phase 3 | Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus Trisulfate Solution Using 2-Day Split-Dosing Regimen in Adults | September 2014 | June 2015 |
| NCT02269631 | Completed | N/A | Legume Diet Satiety Pilot Study | December 2014 | December 2017 |
| NCT02273141 | Completed | Phase 3 | Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus a Sodium Picosulfate and Magnesium Salt Solution Using Day Before-Only Dosing Regimen in Adults. | November 2014 | August 2015 |
| NCT02273167 | Completed | Phase 3 | Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus MOVIPREP® Using 2-Day Split-Dosing and 1-Day Morning Split-Dosing Regimen in Adults. | October 2014 | August 2015 |
| NCT02298946 | Completed | Phase 1 | AMP-224, a PD-1 Inhibitor, With Stereotactic Body Radiation Therapy in Metastatic Colorectal Cancer | November 21, 2014 | March 7, 2017 |
| NCT02337946 | Completed | Phase 2 | Safety and Efficacy Study of mFOLFOX6 + Panitumumab Combination Therapy and 5-FU/LV + Panitumumab Combination Therapy in Participants With Chemotherapy-naïve Unresectable Advanced Recurrent Colorectal Carcinoma | October 16, 2014 | August 31, 2017 |
| NCT02347735 | Completed | Predictive Factors for Anastomotic Leakage After Colorectal Surgery | August 2015 | July 1, 2021 | |
| NCT02355262 | Completed | CATCH-UP Intervention in Increasing Cancer Screening and Prevention Care in Uninsured Patients at Community Health Centers | July 1, 2014 | June 30, 2020 | |
| NCT02373020 | Completed | Enteropathogenic Escherichia Coli (EPEC): Does it Have a Role in Colorectal Tumourigenesis? | January 2011 | March 2013 | |
| NCT02460198 | Completed | Phase 2 | Study of Pembrolizumab (MK-3475) as Monotherapy in Participants With Previously-Treated Locally Advanced Unresectable or Metastatic Colorectal Cancer (MK-3475-164/KEYNOTE-164) | August 25, 2015 | February 19, 2021 |
| NCT02563002 | Completed | Phase 3 | Study of Pembrolizumab (MK-3475) vs Standard Therapy in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Carcinoma (MK-3475-177/KEYNOTE-177) | November 30, 2015 | July 17, 2023 |
| NCT02694562 | Completed | N/A | Microparticle Enhanced Cytotoxic Transarterial Embolization Therapy | November 2013 | December 2016 |
| NCT02729298 | Completed | Phase 1 | First-in-human Study of Oral TP-0903 (a Novel Inhibitor of AXL Kinase) in Patients With Advanced Solid Tumors | December 14, 2016 | June 29, 2022 |
| NCT03064308 | Completed | N/A | The Assessment of the Feasibility of a Home Based Exercise Programme in the Older Patient Following Major Surgery | June 26, 2017 | July 27, 2018 |
| NCT03078348 | Completed | N/A | Increasing Access to Colorectal Cancer Testing (IACCT) for Blacks | December 5, 2011 | May 3, 2017 |
| NCT03078361 | Completed | N/A | Latinos CARES (Colorectal Cancer Awareness, Research, Education and Screening) | April 28, 2014 | October 26, 2022 |
| NCT03086096 | Completed | CIRSE Registry for LifePearl Microspheres | February 2, 2018 | April 30, 2022 | |
| NCT03115372 | Completed | N/A | Lay Health Worker Outreach in Increasing Colorectal Cancer Screening in Asian Americans | February 2012 | September 1, 2015 |
| NCT03142516 | Completed | Phase 2 | FOLFIRI + Panitumumab First-line Treatment in Elderly Patients With Unresectable Metastatic Colorectal Cancer, RAS/BRAF Wild-type and Good Performance Status | October 31, 2017 | January 21, 2021 |
| NCT03152565 | Completed | Phase 1/Phase 2 | Avelumab Plus Autologous Dendritic Cell Vaccine in Pre-treated Metastatic Colorectal Cancer Patients | March 12, 2018 | October 5, 2020 |
| NCT03206073 | Completed | Phase 1/Phase 2 | A Phase I/II Study of Pexa-Vec Oncolytic Virus in Combination With Immune Checkpoint Inhibition in Refractory Colorectal Cancer | December 7, 2017 | June 30, 2022 |
| NCT03300570 | Completed | Phase 1 | Dolcanatide in Preventing Colorectal Cancer in Healthy Volunteers | July 27, 2018 | May 17, 2021 |
| NCT03332498 | Completed | Phase 1/Phase 2 | Pembrolizumab in Combination With Ibrutinib for Advanced, Refractory Colorectal Cancers | January 24, 2018 | September 9, 2021 |
| NCT03367611 | Completed | N/A | Use of iFOBT in Patients Presenting With Alarm Symptoms of Colorectal Cancer | March 15, 2018 | December 31, 2019 |
| NCT03428958 | Completed | Phase 1/Phase 2 | A Safety, Pharmacokinetic and Efficacy Study of NUC-3373 in Combination With Standard Agents Used in Colorectal Cancer Treatment | October 16, 2018 | March 21, 2024 |
| NCT03517488 | Completed | Phase 1 | A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors | July 10, 2018 | September 6, 2022 |
| NCT03546127 | Completed | Molecular Profiling to Improve Outcome of Patients in Cancer. A Pilot Study | May 23, 2017 | September 21, 2017 | |
| NCT03630354 | Completed | N/A | EXERCISING TOGETHER for Couples Coping With Cancer | January 18, 2019 | January 1, 2024 |
| NCT03717519 | Completed | Elevated Platelet Count as Prognostic Factor in Colorectal Cancer With Synchronous Liver Metastases | January 1, 2018 | September 1, 2018 | |
| NCT03849469 | Completed | Phase 1 | A Study of XmAb®22841 Monotherapy & in Combination w/ Pembrolizumab in Subjects w/ Selected Advanced Solid Tumors | May 29, 2019 | February 16, 2023 |
| NCT03958500 | Completed | N/A | The Problem of Colorectal Anastomosis Safety | April 1, 2019 | January 31, 2022 |
| NCT04080414 | Completed | N/A | Home-based HIIT to Improve CRC Survivorship: Feasibility and Relationship With Novel Surrogate Biomarkers of CRC Recurrence | August 2, 2019 | February 12, 2021 |
| NCT04166383 | Completed | Phase 2 | VB-111 in Combination With Nivolumab in People With Metastatic Colorectal Cancer (mCRC) | August 9, 2020 | December 31, 2022 |
| NCT04208724 | Completed | N/A | Support Program for Adoption of Cancer Screening Interventions at a Rural Community-Based Organization | November 18, 2020 | June 30, 2022 |
| NCT04444232 | Completed | N/A | Cancer Communication Within Hispanic Social Networks | September 9, 2014 | March 9, 2015 |
| NCT04490551 | Completed | N/A | Combining Risk Factors and Faecal Immunochemical Testing in Colorectal Cancer Screening: a Randomized Controlled Trial | December 5, 2019 | June 1, 2021 |
| NCT04494919 | Completed | Novel Stent Placement Technique for Intestinal Stenosis Assisted by an Ultrafine Endoscope | June 1, 2018 | June 30, 2020 | |
| NCT04607291 | Completed | Phase 1 | Health Service Intervention for the Improvement of Access and Adherence to Colorectal Cancer Screening | September 1, 2019 | May 14, 2021 |
| NCT04898842 | Completed | N/A | Feasibility Study of a 4 Stage Bowel Obstruction Cancer Diet | March 2, 2021 | November 2, 2022 |
| NCT04980443 | Completed | N/A | Evaluation of a New Blood-based Test to Detect Colorectal Cancer and Its Precursors | August 3, 2021 | November 1, 2022 |
| NCT05021172 | Completed | N/A | Incorporating ePrognosis for the Encouragement of Smarter Screening for Breast and Colorectal Cancer in Older Adults | August 24, 2021 | June 30, 2022 |
| NCT05022511 | Completed | N/A | Three Birds With One Stone | September 1, 2021 | September 1, 2023 |
| NCT05083338 | Completed | Psychological, Psychophysical and Epigenetic Determinants of Chronic Pain After Cytoreductive - Hyperthermic Intraoperative Chemotherapy | August 10, 2021 | February 9, 2024 | |
| NCT05116696 | Completed | Comparison of Outcomes of Patients With Stage IV Chronic Limb-threatening Ischemia and Colorectal Cancer | March 1, 2021 | October 15, 2021 | |
| NCT05162248 | Completed | Microsatellite Instability in Colorectal Cancers | April 1, 2021 | August 1, 2021 | |
| NCT05458986 | Completed | N/A | A Video Intervention to Decrease Patient Fear of Colonoscopy After a Positive Fecal Immunochemical Test | May 15, 2023 | May 3, 2024 |
| NCT05810714 | Completed | N/A | Audio and Video Brochures for Increasing Colorectal Cancer Screening Among Adults Living in Appalachia | November 20, 2021 | February 1, 2022 |
| NCT04081779 | Enrolling by invitation | N/A | Survivorship Care Plans and Telehealth Education for the Improvement of Access to Cancer Survivorship, the IMPACT Study | February 19, 2020 | December 31, 2025 |
| NCT03554434 | No longer available | An Expanded Access Program for AM0010 (Pegilodecakin) | |||
| NCT06376565 | Not yet recruiting | N/A | Improving Colonoscopy Surveillance for Patients With High Risk Colon Polyps | July 5, 2024 | March 2028 |
| NCT06115733 | Not yet recruiting | N/A | Study of Fuquinitinib Combined With Capecitabine First-line Maintenance in the Treatment of Metastatic Colorectal Cancer | December 28, 2023 | December 31, 2026 |
| NCT04562727 | Not yet recruiting | N/A | Microwave Ablation Combined With Chemotherapy for Colorectal Liver Metastases： a Multicenter Cohort Study | March 1, 2021 | September 1, 2026 |
| NCT06130826 | Not yet recruiting | Phase 1 | Immune Response Activation for the Treatment of Unresectable Metastatic Colorectal Cancer or CEA Positive Metastatic Breast Cancer | June 12, 2024 | October 22, 2026 |
| NCT05881746 | Not yet recruiting | N/A | Anatomical Resection VS. Nonanatomical Resection for Colorectal Liver Metastases With Gene Mutation or Right-sidedness | July 1, 2023 | July 1, 2028 |
| NCT06418204 | Not yet recruiting | Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics | August 2024 | August 2028 | |
| NCT05630794 | Not yet recruiting | Phase 1 | Testing ONC201 to Prevent Colorectal Cancer | October 8, 2024 | January 1, 2028 |
| NCT03654131 | Recruiting | Phase 2 | Stereotactic Body Radiation Therapy vs. Microwave Ablation for Colorectal Cancer Patients With Metastatic Disease in the Liver | July 25, 2018 | July 25, 2026 |
| NCT06063928 | Recruiting | Confronting Cancer as a Community | May 25, 2022 | May 25, 2028 | |
| NCT05215574 | Recruiting | Phase 1 | Study of NGM831 as Monotherapy and in Combination With Pembrolizumab or Pembrolizumab and NGM438 in Advanced or Metastatic Solid Tumors | March 31, 2022 | March 2026 |
| NCT02628067 | Recruiting | Phase 2 | Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158) | December 18, 2015 | May 4, 2027 |
| NCT05663203 | Recruiting | N/A | A Web-Based Dyadic Intervention for Colorectal Cancer | May 1, 2023 | November 1, 2025 |
| NCT02611024 | Recruiting | Phase 1/Phase 2 | Pharmacokinetic Study of Lurbinectedin in Combination With Irinotecan in Patients With Selected Solid Tumors | May 6, 2016 | March 2026 |
| NCT06285097 | Recruiting | Phase 1 | A Study of PF-07820435 as a Single Agent and in Combination in Participants With Advanced Solid Tumors | February 8, 2024 | April 29, 2028 |
| NCT06233253 | Recruiting | N/A | Online Mindfulness-Based Intervention to Decrease Pre-Procedural Anxiety Before a First-Time Screening Colonoscopy | September 29, 2023 | December 31, 2024 |
| NCT06218914 | Recruiting | Phase 1 | A Study of NT-112 in HLA-C*08:02-Positive Adult Subjects With Unresectable, Advanced, and/ or Metastatic Solid Tumors Positive for the KRAS G12D Mutation | February 5, 2024 | January 2, 2040 |
| NCT03822572 | Recruiting | N/A | ABCSG C08-Exercise II: Trial of Endurance Exercise Following Adjuvant Chemotherapy for Colorectal Cancer | February 14, 2019 | December 2026 |
| NCT05716477 | Recruiting | Blood Test (Guardant Shield™) for Screening of Colorectal Cancer in Underserved Patients | December 23, 2022 | December 31, 2025 | |
| NCT05746195 | Recruiting | N/A | Optimization of Adaptive Text Messages for Cancer Survivors (OATS II) | November 3, 2023 | November 30, 2024 |
| NCT04069455 | Recruiting | N/A | ePRO for Adjuvant Therapy of Colorectal Adenocarcinoma | October 1, 2019 | September 30, 2024 |
| NCT05783622 | Recruiting | Phase 1 | Study of JANX008 in Subjects With Advanced or Metastatic Solid Tumor Malignancies | April 19, 2023 | October 2027 |
| NCT05786924 | Recruiting | Phase 1 | A Study of BDTX-4933 in Patients With KRAS, BRAF and Select RAS/MAPK Mutation-Positive Cancers | April 18, 2023 | December 2026 |
| NCT05799820 | Recruiting | Phase 2 | QL1706 Monotherapy or in Combination With Bevacizumab and XELOX as First-line Treatment of Unresectable Advanced or Metastatic CRC | September 29, 2022 | September 30, 2025 |
| NCT03001362 | Recruiting | N/A | Patients With Rectal Cancer: a "Wait-and-see" Approach | March 2015 | January 31, 2026 |
| NCT05358249 | Recruiting | Phase 1/Phase 2 | Platform Study of JDQ443 in Combinations in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation | October 24, 2022 | June 16, 2027 |
| NCT04392050 | Recruiting | A Community-Based Educational Intervention to Improve Colorectal Cancer Screening | January 31, 2020 | March 5, 2025 | |
| NCT04430738 | Recruiting | Phase 1/Phase 2 | Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal Cancers | September 15, 2020 | October 31, 2025 |
| NCT05236972 | Recruiting | Phase 3 | PACE: PD-1 Antibody For dMMR/MSI-H Stage III Colorectal Cancer | January 1, 2022 | December 31, 2028 |
| NCT04489238 | Recruiting | Collection of Information to Better Understand Young Onset Colorectal Cancer | July 22, 2020 | July 22, 2025 | |
| NCT05867303 | Recruiting | Phase 1 | A RC198 Study in Subjects With Locally Advanced Unresectable or Metastatic Solid Tumors | June 5, 2023 | September 30, 2024 |
| NCT05410977 | Recruiting | Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients, CORAL Study | March 30, 2022 | April 1, 2026 | |
| NCT05877599 | Recruiting | Phase 1 | A Study of NT-175 in Adult Subjects With Unresectable, Advanced, and/or Metastatic Solid Tumors That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation | July 27, 2023 | August 2039 |
| NCT05447923 | Recruiting | N/A | Addressing Disparities in Colorectal Cancer Screening in Black and Underserved Phoenix Communities | May 22, 2022 | June 1, 2025 |
| NCT02073500 | Recruiting | Peritoneal Surface Malignancies - Characterization, Models and Treatment Strategies | September 2009 | August 2027 | |
| NCT02758951 | Recruiting | Phase 2/Phase 3 | Perioperative Systemic Therapy for Isolated Resectable Colorectal Peritoneal Metastases | June 1, 2017 | August 1, 2026 |
| NCT04666727 | Recruiting | Role of Diet on the Microbiome of the Digestive System | September 29, 2020 | January 1, 2026 | |
| NCT04781270 | Recruiting | Phase 3 | mFOLFOXIRI+Bev vs. mFOLFOX6+Bev for RAS Mutant Unresectable Colorectal Liver-limited Metastases | April 15, 2021 | March 30, 2026 |
| NCT04812912 | Recruiting | Changes in Reproductive and Sexual Health in People With Early Onset Colorectal Cancer | March 18, 2021 | March 18, 2025 | |
| NCT04851119 | Recruiting | Phase 1/Phase 2 | Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors | November 8, 2021 | June 30, 2028 |
| NCT05223036 | Recruiting | Phase 2 | Testing Obeticholic Acid for Familial Adenomatous Polyposis | January 19, 2023 | February 21, 2026 |
| NCT06090643 | Recruiting | N/A | Implementation Research to Increase Colorectal Cancer Screening Rates Among Low Income and Ethnic Minority Groups | November 1, 2019 | November 1, 2025 |
| NCT03366155 | Recruiting | Phase 2 | Hepatic Artery Infusion Pump Chemotherapy With Floxuridine and Dexamethasone in Combination With Systemic Chemotherapy for Patients With Colorectal Cancer Metastatic to the Liver | June 24, 2019 | December 30, 2030 |
| NCT03597581 | Recruiting | Phase 1 | A Study of RGX-202-01 (Ompenaclid) as Combination Therapy in RAS Mutant Advanced Colorectal Cancer | June 5, 2018 | December 31, 2024 |
| NCT04912765 | Recruiting | Phase 2 | Neoantigen Dendritic Cell Vaccine and Nivolumab in HCC and Liver Metastases From CRC | April 15, 2021 | May 2025 |
| NCT04767984 | Recruiting | Phase 2 | Testing Atorvastatin to Lower Colon Cancer Risk in Longstanding Ulcerative Colitis | September 24, 2021 | December 31, 2024 |
| NCT04108481 | Suspended | Phase 1/Phase 2 | Immunotherapy With Y90-RadioEmbolization for Metastatic Colorectal Cancer | October 5, 2020 | December 31, 2025 |
| NCT03050814 | Terminated | Phase 2 | Standard of Care Alone or in Combination With Ad-CEA Vaccine and Avelumab in People With Previously Untreated Metastatic Colorectal Cancer QUILT-2.004 | April 5, 2017 | August 25, 2021 |
| NCT05291988 | Terminated | N/A | A Multilevel Approach for Improvement in Screening of Colorectal Cancer in Rural Communities, The Screen to Save Trial | October 8, 2022 | November 4, 2022 |
| NCT01126866 | Terminated | Phase 2 | Curative Resectability of Not Optimally Resectable Liver and/or Lung Metastases From Colorectal Carcinoma (CRC) Under Intensified Chemotherapy | June 2009 | June 2011 |
| NCT03592641 | Terminated | Phase 2 | Savolitinib in Treating Patients With MET Amplified Metastatic or Unresectable Colorectal Cancer | July 25, 2019 | December 30, 2021 |
| NCT04348916 | Terminated | Phase 1 | Study of ONCR-177 Alone and in Combination With PD-1 Blockade in Adult Subjects With Advanced and/or Refractory Cutaneous, Subcutaneous or Metastatic Nodal Solid Tumors or With Liver Metastases of Solid Tumors | May 20, 2020 | May 31, 2023 |
| NCT01545141 | Terminated | Phase 1/Phase 2 | Chemokine-Modulatory Regimen for Recurrent Resectable Colorectal Cancer | October 2012 | April 8, 2017 |
| NCT01816659 | Terminated | Phase 1 | An Open-Labeled Pilot Study of Biomarker Response Following Short-Term Exposure to Metformin | May 2013 | August 2014 |
| NCT01483638 | Terminated | Phase 2 | Axitinib as Maintenance Treatment in Patients With Metastatic CRC | February 2012 | September 2015 |
| NCT04628780 | Terminated | Phase 1 | Study to Test the Safety and Tolerability of PF-07209960 in Advanced or Metastatic Solid Tumors | December 16, 2020 | May 26, 2023 |
| NCT00405561 | Terminated | Phase 2/Phase 3 | Study to Evaluate Progression Free Survival in Cancer Patients With Advanced Colorectal Carcinoma With AMT2003 | October 2006 | January 2010 |
| NCT00361244 | Terminated | Phase 1/Phase 2 | SU011248 in Combination With Irinotecan and Cetuximab as a Second Line Regimen for Stage IV Colorectal Cancer | July 2006 | August 2010 |
| NCT02365662 | Terminated | Phase 1 | A Study Evaluating Safety and Pharmacokinetics of ABBV-221 in Subjects With Advanced Solid Tumor Types Likely to Exhibit Elevated Levels of Epidermal Growth Factor Receptor | January 9, 2015 | March 15, 2018 |
| NCT00288444 | Terminated | Phase 1 | Interaction of Docetaxel and Lonafarnib in Patients With Advanced Cancer | January 2006 | March 2009 |
| NCT01466504 | Terminated | Effect of Sorafenib or Regorafenib on P63 Expression and Keratinocyte Differentiation in Human Skin | May 2011 | April 2013 | |
| NCT02423954 | Terminated | Phase 1/Phase 2 | Study of Nivolumab Plus Chemotherapy in Patients With Advanced Cancer (NivoPlus) | April 2015 | November 1, 2017 |
| NCT01418742 | Terminated | Phase 2 | SKIP - A Double-blind Placebo-controlled Randomized Multicenter Trial of Skin Toxicity Treatment | August 2011 | May 2013 |
| NCT02577588 | Terminated | Phase 1 | Trial of Adoptive T Cell Therapy With Activated P53 Specific T Cells for Treatment of Advanced Colorectal Cancer | May 1, 2016 | February 19, 2018 |
| NCT02652702 | Terminated | Phase 2 | Study Comparing Circular Stapler-assisted Colostomy vs Hand-stitching Colostomy of Colorectal Cancer Patients | December 2016 | January 2020 |
| NCT02669914 | Terminated | Phase 2 | MEDI4736 (Durvalumab) in Patients With Brain Metastasis From Epithelial-derived Tumors | September 12, 2016 | January 11, 2018 |
| NCT03029988 | Terminated | Phase 1 | An Evaluation of Tilmanocept by IV Injection Using SPECT/CT vs PET Imaging in Subjects With Liver Metastases. | July 26, 2017 | September 24, 2018 |
| NCT01329809 | Terminated | Phase 2 | Neoadjuvant Study of Recombinant Vaccinia Virus to Treat Metastatic Colorectal Carcinoma in Patients Undergoing Complete Resection of Liver Tumors | October 2011 | March 2013 |
| NCT01233544 | Terminated | Phase 3 | Radiofrequency Ablation Versus Stereotactic Radiotherapy in Colorectal Liver Metastases | September 2010 | December 2014 |
| NCT02376452 | Unknown status | Phase 2 | Phase II Study of 2-weekly RAILIRI Versus FOLFIRI as Second-line Treatment in Advanced Colorectal Cancer Patients | September 2014 | December 2016 |
| NCT02243735 | Unknown status | Phase 4 | Trial Comparing Ferric(III)Carboxymaltose Infusion With Oral Iron Suppletion as Treatment of Anaemia | November 2014 | December 2019 |
| NCT02839954 | Unknown status | Phase 1/Phase 2 | CAR-pNK Cell Immunotherapy in MUC1 Positive Relapsed or Refractory Solid Tumor | July 2016 | July 2018 |
| NCT01348256 | Unknown status | Phase 2 | Study With Dendritic Cell Immunotherapy in Resected Hepatic Metastasis of Colorectal Carcinoma | November 2010 | December 2018 |
| NCT02935764 | Unknown status | Phase 3 | FOLFIRI Versus Irinotecan as Second-line Treatment in Metastatic Colorectal Cancer Patients | October 2016 | |
| NCT01157052 | Unknown status | Phase 1 | Oxaliplatin Pharmacokinetics With and Without Ca2+/MG2+ Infusion in Colorectal Cancer Patients | January 2015 | September 2015 |
| NCT04988191 | Unknown status | Phase 1/Phase 2 | Toripalimab Plus Bevacizumab and Chemotherapy as Neoadjuvant Therapy in Advanced MSI-H or dMMR Colorectal Cancer | December 24, 2020 | December 24, 2023 |
| NCT04148378 | Unknown status | A Pilot Study to Explore the Role of Gut Flora in Colorectal Cancer | March 2, 2020 | July 2023 | |
| NCT03969784 | Unknown status | N/A | Microparticles in Peritoneal Carcinomatosis of Colorectal Origin | September 1, 2019 | August 31, 2023 |
| NCT02617134 | Unknown status | Phase 1/Phase 2 | CAR-T Cell Immunotherapy in MUC1 Positive Solid Tumor | November 2015 | November 2018 |
| NCT00215722 | Unknown status | Phase 2 | XELOX Plus Cetuximab as First-Line Therapy in Patients With Metastatic Colorectal Cancer | July 2005 | July 2008 |
| NCT03679429 | Unknown status | NBI Versus White Light Endoscopy for Optical Characterization of Neoplastic Polyps in the Colorectum | November 2018 | July 2020 | |
| NCT00725400 | Withdrawn | Phase 2 | Comparative Study of Cetuximab and Radiation Vs Surgery Before or After Radiation in Patients With Colorectal Carcinoma | February 2010 | February 2014 |
| NCT00735241 | Withdrawn | Phase 2/Phase 3 | FOLFOX6 Plus Sir-Spheres Microspheres Plus Avastin in Patients With Nonresectable Liver Metastases From Colorectal Carcinoma | July 2008 | March 2009 |
| NCT01157039 | Withdrawn | Phase 2 | A Trial of Glutamine to Prevent Oxaliplatin Neurotoxicity and a Pharmacokinetic Analysis of Oxaliplatin | October 2011 | |
| NCT01095523 | Withdrawn | Phase 2 | Prospective Randomized Trial Evaluating Mandatory Second Look Surgery With HIPEC and CRS vs. Standard of Care in Subjects at High Risk of Developing Colorectal Peritoneal Metastases | January 14, 2010 | February 9, 2012 |
| NCT03563352 | Withdrawn | Nutritional Preferences and Product Accessibility in Oral Nutritional Supplements in Participants With Breast, Colorectal, Upper Gastrointestinal, or Prostate Cancer | August 30, 2018 | September 24, 2020 | |
| NCT04870034 | Withdrawn | Early Phase 1 | Binimetinib and Palbociclib Before Surgery for the Treatment of Operable KRAS-Positive Lung, Colorectal, or Pancreatic Cancer | January 15, 2024 | September 30, 2026 |
| NCT03804255 | Withdrawn | Assessment of Current Biomarker Testing Practices for Common Solid Cancers in Precision Oncology in the Community Setting | January 8, 2019 | May 29, 2020 |
- Disase is a (Disease Ontology)
- DOID:9256
- Cross Reference ID (Disease Ontology)
- EFO:1001951
- Cross Reference ID (Disease Ontology)
- MESH:D015179
- Cross Reference ID (Disease Ontology)
- NCI:C2955
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0009402