Clostridium difficile infection
Information
- Disease name
- Clostridium difficile infection
- Disease ID
- Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT02570477 | Active, not recruiting | N/A | FMT for Moderate to Severe CDI: A Randomised Study With Concurrent Stool Microbiota Assessment | January 2015 | December 2024 |
| NCT03829475 | Active, not recruiting | Phase 2 | ICON-2: FMT and Bezlotoxumab Compared to FMT and Placebo for Patients With IBD and CDI | January 1, 2020 | March 1, 2024 |
| NCT04885946 | Active, not recruiting | N/A | Fecal Microbiota Transplantation for Early Clostridioides Difficile Infection | June 2, 2021 | December 31, 2024 |
| NCT01222702 | Completed | Phase 2 | Efficacy, Safety and Tolerability of Cadazolid in Subjects With Clostridium Difficile Associated Diarrhea (CDAD) | January 25, 2011 | November 12, 2012 |
| NCT01230957 | Completed | Phase 2 | Study of Different Formulations of a Clostridium Difficile Toxoid Vaccine Given at Three Different Schedules in Adults | October 2010 | March 2013 |
| NCT01241552 | Completed | Phase 3 | A Study of MK-3415, MK-6072, and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-001) | October 10, 2011 | December 9, 2014 |
| NCT01259726 | Completed | Phase 2 | Safety and Efficacy Study of VP20621 for Prevention of Recurrent Clostridium Difficile Infection | June 27, 2011 | June 11, 2013 |
| NCT01295918 | Completed | Phase 3 | Probiotic Lactobacillus Reuteri to Prevent Antibiotic-associated Diarrhea and Clostridium Difficile-related Infections in Hospitalized Children | February 2011 | September 2013 |
| NCT01296386 | Completed | Phase 1 | An Open-label Study Assessing Safety, Immunogenicity and Dose Response of IC84 | December 2010 | April 2013 |
| NCT01398969 | Completed | Phase 2 | Multi-Centre Trial of Fresh vs. Frozen-and-Thawed FMT for Recurrent CDI | July 2012 | March 2015 |
| NCT01513239 | Completed | Phase 3 | A Study of MK-6072 and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-002) | February 1, 2012 | May 22, 2015 |
| NCT01983683 | Completed | Phase 3 | Efficacy and Safety of Cadazolid Versus Vancomycin in Subjects With Clostridium Difficile-associated Diarrhea | December 12, 2013 | May 2, 2017 |
| NCT00772343 | Completed | Phase 2 | Study of a Clostridium Difficile Toxoid Vaccine (ACAM-CDIFF™) in Subjects With Clostridium Difficile Infection | February 2009 | June 2012 |
| NCT01085591 | Completed | Phase 2 | Study of CB-183,315 in Participants With Clostridium Difficile Infection | April 1, 2010 | May 13, 2011 |
| NCT01704937 | Completed | Phase 1 | Fecal Microbiota Transplant (FMT) for Relapsing C. Difficile Infection in Adults and Children Using a Frozen Inoculum | November 2012 | May 2014 |
| NCT01818141 | Completed | Phase 4 | Study to Assess Inhibition of Spore Production in Patients With C. Difficile Infections: Fidaxomicin Versus Vancomycin | October 17, 2012 | December 15, 2014 |
| NCT01822977 | Completed | Phase 1 | The Impact of Proton Pump Inhibitors on the Fecal Microbiome | March 2013 | December 2013 |
| NCT01896830 | Completed | Phase 1/Phase 2 | Study of a Candidate Clostridium Difficile Toxoid Vaccine in Healthy Adult Subjects Aged 40 to 75 Years in Japan | July 2013 | June 2014 |
| NCT01914731 | Completed | Phase 1 | Fecal Microbiota Transplant for Relapsing Clostridium Difficile Infection in Adults and Children Using a Frozen Encapsulated Inoculum | August 2013 | October 2014 |
| NCT01930032 | Completed | Pathogenic Mechanisms in C Diff Infection and Colitis | August 2013 | January 2014 | |
| NCT01946750 | Completed | N/A | Predictive Value of the Immune Response of the Host in Clostridium Difficile Infections | December 2012 | June 2017 |
| NCT00563186 | Completed | N/A | Hospital Design and Risk of Nosocomial Infections: A Prospective Controlled Trial | June 2007 | February 2010 |
| NCT01987895 | Completed | Phase 3 | Efficacy and Safety of Cadazolid Versus Vancomycin in Subjects With Clostridium Difficile - Associated Diarrhea | March 27, 2014 | March 24, 2017 |
| NCT02053181 | Completed | Phase 1 | Study to Investigate the Pharmacokinetics and Safety of Cadazolid in Patients With Clostridium Difficile Infection | August 2012 | September 2012 |
| NCT02092935 | Completed | Phase 2 | A Study of SMT19969 Compared With Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhoea (CDAD) | April 2014 | October 2015 |
| NCT02106338 | Completed | Phase 1 | Phase I Trial to Determine the Safety and Pharmacokinetics of CRS3123. | June 2014 | December 2014 |
| NCT02214771 | Completed | Description of the Use of fidAxomicin in Hospitalized Patients With Documented Clostridium diFficile iNfection and of the managEment of These Patients | September 3, 2014 | August 17, 2017 | |
| NCT02223715 | Completed | Prospective Observational Study of Clostridium Difficile Infection in Asian Pacific Countries | March 2014 | January 2015 | |
| NCT02326636 | Completed | Fecal Microbiota Transplant for Recurrent Clostridium Difficile Infection | April 2014 | October 26, 2018 | |
| NCT02327520 | Completed | Clostridium Difficile Infection: the First Report in Southeast Asia by 2010 Nationwide Study | January 2010 | December 2014 | |
| NCT02461901 | Completed | Does Fidaxomicin Therapy Reduce Spread of Clostridium Difficile? | January 2015 | December 2017 | |
| NCT02589847 | Completed | Phase 2 | Microbiota Restoration Therapy for Recurrent Clostridium Difficile Infection | October 2015 | March 2019 |
| NCT02743234 | Completed | Phase 3 | Fecal Microbiota Transplantation for Relapsing Clostridium Difficile Infection | April 2016 | August 31, 2019 |
| NCT02784002 | Completed | Phase 2 | A Study of Ridinilazole (SMT19969) Compared With Fidaxomicin for the Treatment of Clostridium Difficile Infection (CDI) | December 2014 | August 2016 |
| NCT02830542 | Completed | Phase 1 | SER-262 Versus Placebo in Adults With Primary Clostridium Difficile Infection to Prevent Recurrence | August 2016 | August 2018 |
| NCT02865616 | Completed | Phase 1 | MET-2 Clinical Study for Recurrent Clostridium Difficile Infection (CDI) | October 27, 2017 | March 17, 2020 |
| NCT02951702 | Completed | Phase 4 | Oral Vancomyin for Primary Clostridium Difficile Infection Prophylaxis in Patients Receiving High-Risk Antibiotics | November 2016 | July 2017 |
| NCT02968758 | Completed | N/A | Validation of the GenePOC CDiff Assay for the Detection of the Toxin B Gene From Toxigenic Clostridium Difficile Strains | February 6, 2017 | August 10, 2017 |
| NCT02981316 | Completed | Phase 1 | Treatment of Recurrent Clostridium Difficile Infection With RBX7455 | November 2016 | July 22, 2020 |
| NCT02996487 | Completed | Phase 4 | Screening to Prophylax Against Clostridium Difficile Infection - | December 2016 | June 28, 2023 |
| NCT03025672 | Completed | Evaluation of the Cost of a Nosocomial Infection With Clostridium Difficile | April 2015 | January 2017 | |
| NCT03030248 | Completed | Phase 2 | Vancomycin for C Difficile NAAT+/EIA- Hematology Oncology Patients | June 1, 2018 | June 30, 2020 |
| NCT03090191 | Completed | Phase 3 | Clostridium Difficile Vaccine Efficacy Trial | March 29, 2017 | December 21, 2021 |
| NCT03106844 | Completed | Phase 1/Phase 2 | The ICON Study: Outcomes After FMT for Patients With IBD and CDI | August 1, 2017 | December 31, 2020 |
| NCT03107169 | Completed | N/A | Treatment of Initial Clostridium Difficile Infection | February 1, 2015 | September 30, 2015 |
| NCT03182907 | Completed | Phase 3 | Bezlotoxumab (MK-6072) Versus Placebo in Children With Clostridium Difficile Infection (CDI) (MK-6072-001) | March 27, 2018 | May 12, 2022 |
| NCT03183128 | Completed | Phase 3 | ECOSPOR III - SER-109 Versus Placebo in the Treatment of Adults With Recurrent Clostridium Difficile Infection | July 10, 2017 | September 29, 2020 |
| NCT03250104 | Completed | Antibiotic Stewardship and Infection Control in Patients at High Risk of Developing Infection by Clostridium Difficile, Vancomycin-Resistant Enterococci or Multi-Resistant Gram-Negatives | November 2016 | July 2019 | |
| NCT03268213 | Completed | Early Phase 1 | Fecal Microbial Transplantation for C. Difficile and/or Ulcerative Colitis or Indeterminate Colitis | November 2013 | February 15, 2022 |
| NCT03349268 | Completed | N/A | Pulsed UV Xenon Disinfection to Prevent Resistant Healthcare Associated Infection | July 7, 2017 | April 15, 2020 |
| NCT03388268 | Completed | Phase 4 | TOX NEG Trial: Clostridium Difficile Diagnosis and Treatment | December 29, 2017 | January 31, 2021 |
| NCT03462459 | Completed | Phase 2 | Efficacy of Oral Vancomycin Prophylaxis for Prevention of Recurrent Clostridium Difficile Infection | May 21, 2018 | July 6, 2023 |
| NCT03466502 | Completed | Phase 4 | Oral Vancomycin to Prevent Recurrent C Difficile Infection With Antibiotics | March 8, 2018 | February 17, 2022 |
| NCT03497806 | Completed | Phase 2 | Open-Label Extension of CP101 Trials Evaluating Oral Full-Spectrum Microbiota™ (CP101) in Subjects With Recurrence of Clostridium Difficile Infection | May 1, 2018 | April 1, 2021 |
| NCT03503474 | Completed | COMBACTE-CDI Understanding the Burden of C. Difficile Infection | June 11, 2018 | September 30, 2019 | |
| NCT03621657 | Completed | Phase 2 | The GRAFT Study: Gut RecolonizAtion by Fecal Transplantation | March 21, 2019 | February 27, 2020 |
| NCT03710694 | Completed | N/A | Safety and Efficacy of DAV132 in Patients at High-Risk for Clostridium Difficile Infection (CDI) | October 31, 2018 | August 9, 2019 |
| NCT03788434 | Completed | Phase 2 | Phase 2 Study of VE303 for Prevention of Recurrent Clostridioides Difficile Infection | February 8, 2019 | September 15, 2021 |
| NCT03824795 | Completed | Phase 2 | Study to Assess Safety, Tolerability and Efficacy of Incremental Doses of MGB-BP-3 in Patients With CDAD | February 7, 2019 | April 3, 2020 |
| NCT03827447 | Completed | Phase 1 | Vancomycin for the Treatment of NAAT(+)/Toxin(-) C. Difficile | July 17, 2019 | June 30, 2021 |
| NCT03925636 | Completed | N/A | Specific Carbohydrate Diet for Clostridium Difficile | June 8, 2016 | March 1, 2022 |
| NCT03931941 | Completed | Phase 3 | Microbiota Restoration Therapy for Recurrent Clostridium Difficile Infection (PUNCH CD3-OLS) | July 30, 2019 | July 21, 2023 |
| NCT04014608 | Completed | Protocol for Admission Toxigenic C. Difficile Surveillance | July 1, 2016 | December 31, 2018 | |
| NCT04075422 | Completed | Bezlotoxumab - in "Real Life" - During the First Episode of Clostridium Difficile Infection in Patients With High Risk of Recurrence. | October 1, 2019 | October 28, 2022 | |
| NCT04090346 | Completed | Phase 4 | Fecal Microbiota Transplant | June 5, 2018 | March 30, 2022 |
| NCT04247542 | Completed | Phase 2 | ACX-362E [Ibezapolstat] for Oral Treatment of Clostridioides Difficile Infection | March 6, 2020 | November 15, 2023 |
| NCT04317963 | Completed | Real-world Evaluation of Bezlotoxumab for the Management of Clostridioides Difficile Infection | February 12, 2020 | February 22, 2023 | |
| NCT04698148 | Completed | Establishment of the Human Intestinal and Salivary Microbiota Biobank - Gastrointestinal Diseases | February 8, 2021 | May 10, 2022 | |
| NCT05008640 | Completed | Creation of an E-toileting Log Through Classification of the Physical Properties of Stool and Urine Using TrueLoo™ | November 14, 2019 | June 18, 2021 | |
| NCT05703477 | Completed | N/A | The Dynamic Fluctuation of Donor Microbiota Affects the Prognosis of Fecal Microbiota Transplantation for C. Difficile Infection | January 1, 2020 | August 30, 2022 |
| NCT01560832 | Completed | Descriptive Epidemiology of Clostridium Difficile Infection in Hospitalized Adult Patients in the Asia Pacific Region | December 2011 | June 2012 | |
| NCT01597505 | Completed | Phase 3 | Study of CB-183,315 in Participants With Clostridium Difficile Associated Diarrhea (MK-4261-005) | May 16, 2012 | March 20, 2015 |
| NCT01598311 | Completed | Phase 3 | A Study of CB-183,315 in Participants With Clostridium Difficile Associated Diarrhea (MK-4261-006) | May 16, 2012 | August 25, 2015 |
| NCT01670149 | Completed | Phase 4 | Rifaximin for Preventing Relapse of Clostridium Associated Diarrhoea | December 2012 | July 2016 |
| NCT03848689 | Enrolling by invitation | FQ Restriction for the Prevention of CDI | May 1, 2019 | June 30, 2024 | |
| NCT04960306 | Not yet recruiting | Phase 3 | Fecal Filtrate as a Treatment Option of Multiple Recurrent Clostridioides Difficile Infection | November 1, 2023 | December 1, 2025 |
| NCT06367504 | Not yet recruiting | N/A | A Study to Assess the Effect of Doctor's Biome Medical Food in Individuals With Clostridium Difficile Infection | July 15, 2024 | December 30, 2024 |
| NCT03325855 | Recruiting | Fecal Microbiota Transplant National Registry | September 20, 2017 | August 2027 | |
| NCT05192148 | Recruiting | N/A | Seroprevalence of Antibodies to Surface Antigens and Toxins of Clostridioides Difficile | November 30, 2021 | December 30, 2024 |
| NCT04014413 | Recruiting | N/A | Safety and Efficacy of Fecal Microbiota Transplantation | July 15, 2019 | October 31, 2030 |
| NCT04801862 | Recruiting | Natural History of Clostridioides Difficile Infection | January 1, 2021 | December 31, 2024 | |
| NCT03562741 | Recruiting | N/A | Outcomes and Data Collection for Fecal Microbiota Transplantation for the Treatment of Recurrent Clostridium Difficile | January 16, 2014 | January 16, 2027 |
| NCT04940468 | Recruiting | N/A | High- Fiber/ Low-fat Diet for Prevention of Recurrent Clostridioides Difficile Infection in Oncology | October 21, 2022 | December 18, 2025 |
| NCT03712722 | Recruiting | Fecal Microbiota Transplantation (FMT) for Clostridium Difficile | October 1, 2018 | December 31, 2024 | |
| NCT04138706 | Recruiting | Phase 3 | Initial Vancomycin Taper for the Prevention of Recurrent Clostridium Difficile Infection | November 19, 2020 | September 30, 2024 |
| NCT04305769 | Recruiting | Phase 2 | Alanyl-glutamine Supplementation for C. Difficile Treatment (ACT) | June 1, 2021 | June 30, 2027 |
| NCT03350711 | Suspended | A Screening and Recruitment Study in Adults Expressing Interest in the Emory Microbiota Enrichment Program | September 13, 2018 | January 2028 | |
| NCT02053350 | Terminated | Phase 2 | Alanyl-glutamine Supplementation of Standard Treatment for C. Difficile Infection | April 2015 | April 5, 2017 |
| NCT00772954 | Terminated | Phase 1 | Phase I Randomized, Placebo-Controlled, Double-Blind, Dose Ranging Study, Safety, Tolerability and Immunogenicity | March 2006 | June 2006 |
| NCT01887912 | Terminated | Phase 3 | Study of a Candidate Clostridium Difficile Toxoid Vaccine in Subjects at Risk for C. Difficile Infection | July 30, 2013 | June 12, 2018 |
| NCT02301000 | Terminated | Phase 2/Phase 3 | IMT for Primary Clostridium Difficile Infection | February 22, 2015 | November 16, 2017 |
| NCT02255305 | Terminated | Phase 2 | FMT Versus Antimicrobials for Initial Treatment of Recurrent CDI | January 2015 | January 2020 |
| NCT03200093 | Terminated | Phase 4 | Oral Vancomycin for Preventing Clostridium Difficile Recurrence | June 8, 2017 | April 22, 2021 |
| NCT02395848 | Terminated | Phase 3 | Efficacy of 30-day Duration of Fidaxomicin for Recurrent C. Difficile Infection | July 2015 | August 30, 2021 |
| NCT03005379 | Terminated | Phase 2/Phase 3 | Microbiota or Placebo After Antimicrobial Therapy for Recurrent C. Difficile at Home (MATCH) | November 15, 2018 | January 31, 2023 |
| NCT02991417 | Terminated | Phase 1 | Oral Vaccination Against Clostridium Difficile Infection | January 2017 | June 8, 2017 |
| NCT04000555 | Terminated | Phase 4 | Oral Vancomycin for Secondary Prophylaxis of Clostridium Difficile Infection (CDI) | September 1, 2019 | June 11, 2022 |
| NCT01372943 | Terminated | N/A | Harnessing the Healthy Gut Microbiota to Cure Patients With Recurrent C. Difficile Infection | January 2010 | August 31, 2018 |
| NCT03105479 | Terminated | Phase 2/Phase 3 | Comparison of Cadazolid Versus Vancomycin in Children With Clostridium Difficile-associated Diarrhea (CDAD) | April 14, 2017 | April 17, 2018 |
| NCT03065374 | Terminated | Phase 1/Phase 2 | Treatment for Clostridium-difficile Infection With IMM529 | September 1, 2017 | November 7, 2019 |
| NCT02707198 | Terminated | Phase 2 | Prevention of Clostridium Difficile-associated Diarrhea by Daily Intake of Kefir | November 2015 | May 10, 2019 |
| NCT03795233 | Terminated | Phase 1/Phase 2 | Fecal Microbiota Transplant for Primary CDI | August 23, 2019 | January 15, 2021 |
| NCT01972932 | Terminated | Phase 4 | Study of Bio-K+® in the Reduction of the Risk of Clostridium Difficile Infection and Antibiotic Associated Diarrhea | November 2013 | August 2017 |
| NCT02016820 | Terminated | N/A | Effect of Acid Suppression Medication on Pediatric Microbiome | November 2014 | January 2017 |
| NCT02237859 | Unknown status | Phase 4 | Vancomycin Prophylaxis in Recurrent Clostridium Difficile Infection | August 2014 | August 2016 |
| NCT03834038 | Unknown status | N/A | Lyophilized Fecal Microbiota Transplantation for Recurrent Clostridium Difficile Infection | February 18, 2016 | March 2020 |
| NCT03141775 | Unknown status | Incidence and Economic Burden of Clostridium Difficile Infections (CDI) in the German Health Care System (IBIS) | August 1, 2017 | June 2019 | |
| NCT04567134 | Unknown status | Clostridioides Difficile Infection - a Prospective Nationwide Epidemiologic Study in Korea | October 1, 2020 | December 31, 2022 | |
| NCT01905709 | Unknown status | N/A | Fecal Microbiota Transplantation for C Diff Infection | July 2013 | December 2023 |
| NCT04012788 | Unknown status | N/A | CDI Synbiotic Study | July 2019 | March 1, 2021 |
| NCT01942447 | Unknown status | N/A | Fecal Microbiota Transplantation in Recurrent or Refractory Clostridium Difficile Colitis | October 2013 | May 2015 |
| NCT01958463 | Unknown status | Phase 3 | Transplantation of Fecal Microbiota for Clostridium Difficile Infection | November 2013 | December 2016 |
| NCT02086916 | Unknown status | Novel Biomarkers to Predict Outcome in Clostridium Difficile Infection | October 2011 | December 2015 | |
| NCT04100603 | Unknown status | A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Clostridoides Difficile Infection | March 2, 2020 | July 31, 2023 | |
| NCT03586206 | Unknown status | Relationship Between C. Difficile Toxins' Serum Level With C. Difficile Infection | September 15, 2018 | December 31, 2020 | |
| NCT02399618 | Unknown status | Phase 1 | Freeze-dried, Capsulized FMT for RCDI | March 2015 | December 2016 |
| NCT02557685 | Unknown status | Phase 2 | Gut Microbiota Changes After Fecal Microbiota Transplantation | June 2015 | March 2017 |
| NCT04187430 | Unknown status | Validation of a Prediction Score for Recurrent C. Difficile Infection: Implementation for Treatment Algorithm Strategies | December 1, 2019 | December 31, 2020 | |
| NCT02686645 | Unknown status | Phase 2/Phase 3 | Fecal Microbiota Therapy for Recurrent Clostridium Difficile Infection | December 2016 | December 2021 |
| NCT03654872 | Unknown status | Clostridium Difficile Virulence Mechanism Study (CDVM Study) | June 30, 2018 | May 30, 2019 | |
| NCT04259931 | Unknown status | PROSPECTIVE STUDY OF PREDISPOSING FACTORS OF REFRACTARY Clostridium Difficile INFECTION. INFLUENCE OF THE GUT MICROBIOMA | March 1, 2020 | June 1, 2021 | |
| NCT03796650 | Unknown status | Phase 3 | Fecal Transplantation for Primary Clostridium Difficile Infection | July 17, 2019 | January 31, 2024 |
| NCT03804736 | Unknown status | N/A | Fecal Microbiota Transplant by Oral Capsules With Lactobacilli for Recurrent Clostridium Difficile Infection | November 1, 2016 | December 1, 2019 |
| NCT03053505 | Unknown status | N/A | A Novel Faecal Microbiota Transplantation System for Treatment of Primary and Recurrent Clostridium Difficile Infection | January 2017 | October 2018 |
| NCT01077245 | Withdrawn | Phase 2 | Safety and Clinical Effectiveness of Oral Probiotic MIYA-BM to Prevent Recurrent Clostridium Difficile Infections | February 2010 | November 2013 |
| NCT03592082 | Withdrawn | Phase 4 | Use of Bismuth Subsalicylate in Clostridium Difficile Colitis | March 1, 2018 | July 1, 2018 |
| NCT01552668 | Withdrawn | Phase 4 | Fidaxomicin to Prevent Clostridium Difficile Colonization | September 2012 | December 2013 |
| NCT03643887 | Withdrawn | Phase 2 | Phase II Trial of Fecal Microbiota Transplant (FMT) for VRE and CRE Patients | September 1, 2022 | June 30, 2025 |
| NCT01842347 | Withdrawn | N/A | Treatment of C. Difficile Infection With Fecal Microbiota Transplantation (FMT) | August 2013 | |
| NCT02464306 | Withdrawn | Phase 4 | Fidaxomicin Versus Standard of Care Therapy in Solid Organ Transplant Recipients With Clostridium Difficile Infection | June 2018 | June 2019 |
- MedGen concept unique identifier (MedGen Concept name)
- C0343386
- MedGen unique identifier (MedGen Concept name)
- 575554