hyperuricemia

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Information
Disease name
hyperuricemia
Disease ID
DOID:1920
Description
"An acquired metabolic disease that has_material_basis_in an abnormally high level of uric acid in the blood." [url:http\://en.wikipedia.org/wiki/Hyperuricemia]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT05253833 Active, not recruiting Phase 2 Phase 2 to Assess Efficacy and Safety in AR882 Alone or in Combination With Allopurinol in Patients With Tophaceous Gout August 12, 2022 August 2024
NCT00186940 Completed Rasburicase Treatment for Chemotherapy or Malignancy-Induced Hyperuricemia in Asthma/Allergy Patients March 2005 February 2010
NCT00230178 Completed Phase 3 Rasburicase Versus Allopurinol in Tumor Patients at Risk for Hyperuricemia and Tumor Lysis Syndrome April 2004 December 2007
NCT00230217 Completed Phase 4 Study of Rasburicase as Treatment or Prevention of Hyperuricemia Associated With Tumor Lysis Syndrome in Patients With Relapsed or Refractory Lymphoma, Leukemia, or Solid Tumor Malignancy March 2004 July 2006
NCT00288158 Completed Phase 2 Primary Prevention of Hypertension in Obese Adolescents September 2008 January 2011
NCT00302653 Completed Phase 4 Rasburicase in Tumor Lysis Syndrome February 2006
NCT00422318 Completed Phase 4 Treatment of Hyperuricemia in Patients With Heart Failure January 2004 December 2005
NCT00563771 Completed Phase 4 Rasburicase for Treatment of Hyperuricemia in Children and Adolescence Patients With Tumor Lysis Syndrome March 2003 January 2004
NCT00631579 Completed Phase 2 Rasburicase as a Uricolytic Therapy for Hyperuricemia in Patients With Leukemia or Lymphoma April 2003 June 2004
NCT00174954 Completed Magnetic Resonance Imaging in Subjects With Gouty Tophi March 2002 January 2003
NCT00997542 Completed Phase 4 Allopurinol in Chronic Heart Failure
NCT01052987 Completed Phase 2 Study of Tranilast Alone or in Combination With Allopurinol in Subjects With Hyperuricemia January 2010 November 2010
NCT01109121 Completed Phase 2 Tranilast Plus Allopurinol in Patients With Moderate to Severe Gout (TAnGO) June 2010 January 2011
NCT01265264 Completed Phase 2 Study to Evaluate sUA Lowering Activity, Safety and Efficacy of Oral Ulodesine Added to Allopurinol December 2010 February 2013
NCT01336686 Completed Phase 2 Safety and Efficacy Study of MBX-102 in Treatment of Hyperuricemia in Patients With Gout May 2011 November 2011
NCT01361646 Completed Phase 1 Safety, Tolerability and Pharmacokinetic/Pharmacodynamic Characteristics of LC350189 June 2011 January 2013
NCT01363869 Completed N/A Effects of Green Tea on Level of Serum Uric Acid in Healthy Individuals June 2011 March 2013
NCT01407874 Completed Phase 2 A Randomized, Double-Blind, Dose-Response Study of the Safety and Uric Acid Effects of Oral Ulodesine Added to Allopurinol in Subjects With Gout and Concomitant Moderate Renal Insufficiency September 2011 July 2012
NCT01416402 Completed Phase 2 Open Label Safety/Efficacy Study of Arhalofenate in Combination With Febuxostat for Hyperuricemia in Gout Patients August 2011 October 2011
NCT01532622 Completed N/A Impact of Blueberries on Uric Acid and Quality of Life January 2012 October 2013
NCT01830725 Completed Purine Metabolism Enzyme SNP to Uric Acid Production December 2012 June 2016
NCT01881919 Completed Early Phase 1 Effect of Quercetin Supplements on Healthy Males: a Four-Week Randomized Cross-Over Trial February 2013 November 2014
NCT01931527 Completed N/A Effect of Reducing Uric Acid on Insulin Sensitivity and Oxidative Status July 2006 November 2012
NCT02190786 Completed Phase 2 Phase II Exploratory Clinical Study of KUX-1151
NCT02213562 Completed N/A Effect of Chrysanthemum Flower Oil and Its Dose-dependency on Hyperuricemia July 2014 March 2016
NCT02252835 Completed Phase 2 Evaluate the PK, PD, and Safety of Arhalofenate in Combination With Febuxostat for Hyperuricemia in Patients With Gout August 2014 December 2014
NCT02290210 Completed Phase 2 Phase 2 Study of URC102 to Assess the Efficacy and Safety in Gout Patients July 24, 2014 August 31, 2015
NCT02338128 Completed The Cardiovascular Protective Effects of Febuxostat in Peritoneal Dialysis Patients January 2015 January 2018
NCT02338323 Completed N/A Compare the Renal Protective Effects of Febuxostat and Benzbromarone January 2015 December 2018
NCT02344862 Completed Phase 2 Study of FYU-981 in Hyperuricemia With or Without Gout January 2014 September 2014
NCT02416167 Completed Phase 2 Study of FYU-981 in Hyperuricemia With or Without Gout May 2015 November 2016
NCT02557126 Completed Phase 2 Study of URC102 to Assess the Safety and Efficacy in Gout Patients October 2015 August 2016
NCT02600780 Completed Phase 4 Zurig (Febuxostat) 40mg Efficacy and Safety Trial November 2013 March 2015
NCT02837198 Completed Phase 2 Study of FYU-981 in Hyperuricemia (Effect on Two Hyperuricemic Types) July 2016 March 2018
NCT02956278 Completed Phase 4 The Effects of BCRP Q141K on Allopurinol Pharmacokinetics and Dynamics November 2016 March 2018
NCT02959918 Completed Phase 2 Multi-Dose Safety/Pharmacodynamic Study of SEL-212/SEL-037 in Subjects With Symptomatic Gout & Elevated Blood Uric Acid October 2016 January 2019
NCT03118739 Completed Phase 2 Intensive Uric Acid Lowering With Verinurad and Febuxostat in Patients With Albuminuria May 18, 2017 August 13, 2018
NCT03149939 Completed N/A Use of Febuxostat in Hyperuricemia Among Hemodialysis Patients January 1, 2017 May 1, 2017
NCT03185793 Completed Phase 2 Dose-finding and Safety Study of SHR4640 in Subjects With Hyperuricemia July 20, 2017 July 20, 2018
NCT03211403 Completed Phase 1 Multiple Doses Study of SHR4640 in Male Subjects With High Serum Uric Acid Level July 4, 2017 February 15, 2018
NCT03569020 Completed N/A The Diet Gout Trial August 7, 2018 July 23, 2019
NCT03636529 Completed N/A Tart Cherry Juice and Markers of Inflammation, CVD, and Diabetes June 1, 2010 May 31, 2011
NCT03648996 Completed Phase 2 Sex-related Differences in Arterial Stiffness in Type 2 Diabetics: Role of Uric Acid November 1, 2018 March 10, 2022
NCT03906006 Completed Phase 1 A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ABP-671 in Healthy Subjects October 17, 2018 June 20, 2019
NCT03921736 Completed Phase 4 Reversal of an Unfavorable Effect of Hydrochlorothiazide Compared to Angiotensin Converting Enzyme Inhibitor on Serum Uric Acid and Oxypurines Levels by Estrogen-progestin Therapy in Hypertensive Postmenopausal Women. January 10, 2000 November 17, 2005
NCT03927677 Completed Phase 1 The Effect of Colchicine on the Pharmacokinetic Profile of LC350189 in Healthy Aldults. November 5, 2019 November 26, 2019
NCT03934099 Completed Phase 2 A Study to Assess Efficay and Safety of LC350189 Different Doses in Gout Patients With Hyperuricemia December 2, 2019 May 17, 2021
NCT04040816 Completed Phase 2 Placebo Controlled, Multiple Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SAP-001 in Gout Patients January 1, 2019 August 30, 2020
NCT04060173 Completed Phase 1 A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ABP-671 September 5, 2019 February 7, 2020
NCT04066712 Completed Phase 1 Renal PK Study of LC350189 November 19, 2019 September 12, 2020
NCT04070846 Completed Phase 1 Mass Balance Study of [14C]LC350189 in Healthy Volunteers February 26, 2020 March 7, 2020
NCT04139824 Completed Phase 1 The Effect of Naproxen on the Pharmacokinetic Profile of LC350189 in Healthy Adults January 22, 2020 February 25, 2020
NCT04144088 Completed Phase 2 Traditional Chinese Medicine in the Treatment of Patients With Hyperuricemia. June 1, 2006 June 30, 2007
NCT04161872 Completed Phase 4 Nutraceutical on Hyperuricemia October 1, 2018 December 31, 2019
NCT04165499 Completed Early Phase 1 Effect of the Consumption of a Combination of Plant Extracts (BSL_EP026) on Serum Uric Acid. November 11, 2019 March 20, 2020
NCT04236219 Completed Phase 1 ALLN-346 Single Ascending Dose (SAD) Study in Healthy Volunteers September 2, 2020 November 6, 2020
NCT04638543 Completed Phase 2 A Study to Assess the Efficacy, Safety, and Pharmacokinetics of ABP-671 in Patients With Gout or Hyperuricemia November 27, 2020 October 26, 2021
NCT04829435 Completed Phase 1 Study 102: Multiple Ascending Dose Study of ALLN-346 (Engineered Urate Oxidase) April 21, 2021 June 1, 2021
NCT04886050 Completed Phase 1 Relative Bioavailability Study to Assess an LC350189 Tablet Compared to an LC350189 Capsule in Healthy Adults July 31, 2021 December 10, 2021
NCT04938024 Completed N/A Hmong Microbiome ANd Gout, Obesity, Vitamin C (HMANGO-C) March 28, 2021 August 30, 2023
NCT04966325 Completed Early Phase 1 Thorough QT (TQT) Study to Evaluate the Effect of LC350189 on Cardiac Repolarization in Healthy Male and Female Subjects September 23, 2021 December 7, 2021
NCT04987242 Completed Phase 2 An Inpatient Study of ALLN-346 (Engineered Urate Oxidase) in Hyperuricemic Subjects (Study 201) July 16, 2021 March 2, 2022
NCT05119686 Completed Phase 2 Phase 2b Evaluation of Efficacy and Safety of AR882 in Gout Patients November 16, 2021 November 17, 2022
NCT05168683 Completed Phase 1 Scintigraphy Study in Healthy Volunteers to Characterize the Performance of ALLN-346 Tablets January 11, 2022 February 23, 2022
NCT05474560 Completed Phase 4 Febuxostat Versus Allopurinol on Hepatic Steatosis in MAFLD Patients January 1, 2022 January 28, 2023
NCT06168929 Completed Phase 1 Bioequivalence Study of 2 Sizes of SHR4640 Tablets Orally in Healthy Subjects December 13, 2023 January 13, 2024
NCT06189404 Completed Phase 1 Effect of Tigulixostat on the Pharmacokinetics of Theophylline October 31, 2023 November 30, 2023
NCT00741442 Completed Phase 2 A Study of RDEA806 in Hyperuricemic Subjects With Symptomatic Gout July 2008 September 2009
NCT00756964 Completed Phase 2 Lowering Serum Uric Acid to Prevent Acute Kidney Injury October 2008 August 2011
NCT00868673 Completed N/A The Role Of Fructose and Uric Acid In the Development of Obesity and Metabolic Syndrome March 2009 February 2010
NCT00919243 Completed Phase 4 Prednisone for Heart Failure Patients With Hyperuricemia February 2009 August 2010
NCT00921375 Completed Phase 3 Safety and Efficacy of TULY (Rasburicase) in Prevention and Treatment of Malignancy-associated Hyperuricemia February 2010 January 2012
NCT00955981 Completed Phase 2 Gout Dose Response Study July 2009 September 2011
NCT00978653 Completed N/A The Effect of Uric Acid Decrement on Endothelial Function in Patients With Chronic Renal Failure April 2008 May 2009
NCT00995618 Completed Phase 2 Study of Tranilast Alone or in Combination With Febuxostat in Patients With Hyperuricemia September 2009 April 2010
NCT06463561 Not yet recruiting Phase 4 CPAP Effect on Lipid Profile and Hyperuricemia in Patients With Dyslipidemia and Moderate-severe Obstructive Sleep Apnea June 20, 2024 December 31, 2027
NCT05913310 Not yet recruiting Phase 4 Efficacy and Safety of Kui-Yuan Chewable Tablets in Patients With Hyperuricemia July 2023 August 2024
NCT06310967 Not yet recruiting Phase 1/Phase 2 A Dose Escalation Study of IG3018 in Subjects With Hyperuricemia With or Without Chronic Kidney Disease March 2024 June 2025
NCT05586958 Recruiting Phase 3 Tigulixostat, Phase 3 Study, Placebo Controlled in Gout Patients October 25, 2022 June 2025
NCT06119802 Recruiting Prediction of UA/SOD Ratio as a Biomarker of Oxidative Stress in Atrial Fibrillation January 1, 2022 April 30, 2024
NCT06084585 Recruiting N/A The Efficacy of Amway Uric Acid Lowering Product on Hyperuricemia October 23, 2023 March 15, 2024
NCT06439602 Recruiting Phase 3 Phase 3 Evaluation of Efficacy and Safety of AR882 in Gout Patients June 2024 November 2026
NCT03899883 Recruiting Phase 2 Uric Acid Lowering Trial in Youth Onset T2D January 1, 2020 June 30, 2023
NCT06315543 Recruiting N/A Effect of Increased Daily Water Intake in Patients With Hyperuricemia May 23, 2024 November 1, 2024
NCT06056570 Recruiting Phase 1/Phase 2 Open Label PK, PD and DDI of Dotinurad and Allopurinol in Gout Patients With Hyperuricemia October 2023 November 2023
NCT04801745 Recruiting N/A Vegan Diet, Amla Fruits and Uric Acid March 20, 2021 June 30, 2024
NCT04733079 Recruiting N/A Treat-to-target by Email During Urate-lowering Therapy in Gout December 15, 2021 October 1, 2024
NCT05954169 Recruiting Phase 1 Pharmacokinetic/Pharmacokinetic and Safety Studies of SHR4640 in Subjects With Moderate Renal Insufficiency and Healthy Subjects August 7, 2023 November 10, 2023
NCT04463940 Recruiting Xanthine Oxidase and Uric Acid Origin in Preeclamptic Women June 30, 2020 August 2024
NCT05434858 Recruiting N/A Imagery as Biomarker of Gout September 9, 2022 September 9, 2029
NCT06315569 Recruiting N/A The Effect of Exercise at Different Time Intervals on Hyperuricemia May 24, 2024 November 1, 2024
NCT05476627 Recruiting Risk Factors and Multiomics Study of Chronic Kidney Disease Caused by Metabolic Diseases July 1, 2022 July 1, 2027
NCT04399915 Recruiting Effect of Oxalate and Urate Metabolism on CKD Evolution January 10, 2019 December 2024
NCT04199325 Recruiting N/A Probiotics for Gout / Hyperuricemia: A Randomized, Intervention, Parallel Controlled, Multicenter Clinical Trial November 1, 2018 March 2024
NCT05504083 Recruiting Phase 2 Evaluate the Efficacy and Safety of D-0120 in Primary Hyperuricemia Patients September 28, 2022 April 26, 2024
NCT05574036 Recruiting Phase 2 Comparative Study Between Febuxostat Versus Vitamin E in Non-alcoholic Steatohepatitis Patients With Hyperuricemia August 25, 2022 December 25, 2024
NCT05586971 Recruiting Phase 3 Tigulixostat, Phase 3 Study, Allopurinol Controlled in Gout Patients March 30, 2023 December 2025
NCT03495999 Terminated Hyperuricemia and Left Ventricular Diastolic Function August 1, 2017 April 3, 2018
NCT04987294 Terminated Phase 2 Phase IIa Study of ALLN-346 (Engineered Urate Oxidase) in Subjects With Hyperuricemia, Gout and Chronic Kidney Disease September 2, 2022 September 2, 2022
NCT03865407 Terminated Phase 2 Uric Acid Reduction as a Novel Treatment for Pediatric Chronic Kidney Disease March 10, 2019 October 7, 2020
NCT00607152 Terminated Phase 3 Rasburicase (Fasturtec) Registration Trial October 2007 January 2009
NCT02462421 Terminated Phase 4 Pharmacogenetics of SGLT2 Inhibitors June 1, 2015 December 31, 2021
NCT00664144 Terminated Phase 2 Rasburicase for the Treatment/Prevention of Hyperuricemia in Adult Patients With Relapsing Aggressive Non Hodgkin's Lymphoma July 2002 January 2005
NCT02008968 Unknown status N/A Effect of Allopurinol Treatment on Insulin Resistance December 2013 August 2014
NCT04180982 Unknown status Phase 2 A Safety and Efficacy Study of SHR4640 and Febuxostat in Subjects With Hyperuricemia December 3, 2019 August 30, 2020
NCT01818505 Unknown status The Influence of Antiphospholipid Antibodies on the Relationship Between Hyperurecemia, Gout and Metabolic Syndrome March 2013
NCT02282683 Unknown status Phase 2/Phase 3 Long-term Prednisone Use for End-stage Heart Failure December 2013 December 2017
NCT01519687 Unknown status Phase 2 Study of Levotofisopam 50 mg Three Times a Day (TID) Administered for 7 Days on Hyperuricemia and Gout January 2012 June 2012
NCT04352153 Unknown status N/A Role of Uralyt-U in Patients With Hyperuricemia April 1, 2020 October 31, 2020
NCT01984749 Unknown status N/A Febuxostat for Cerebral and caRdiorenovascular Events prEvEntion stuDy November 2013
NCT04157959 Unknown status Phase 1 The Drug-Drug Interaction of SHR4640 and Febuxostat in Patients With Hyperuricemia October 14, 2019 June 30, 2020
NCT04012294 Unknown status Phase 3 Effects of Allopurinol on Inflammation and Ultrasonographic Changes in People With Elevated Uric Acid But no Symptoms August 30, 2019 February 28, 2021
NCT04586803 Unknown status Phase 1 Study on the Bioavailability of Three Different Prescription Processes of SHR4640 Tablets in Healthy Volunteers October 2020 December 2020
NCT03473951 Unknown status The Relationship Among, Serum Uric Acid, Left Ventricular Hypertrophy and Metabolic Syndrome March 26, 2018 December 2020
NCT02502565 Unknown status Musculoskeletal Ultrasound in Asymptomatic Hyperuricemia January 2012 March 2019
NCT04622124 Unknown status Phase 1 A Safety and Tolerability Study of FCN-207 in Healthy Volunteers November 11, 2020 June 7, 2022
NCT05245890 Unknown status Assocaiton Between Uric Acid Trajecteries and Remission of NAFLD in NAFLD Individuals March 1, 2022 March 1, 2024
NCT05226013 Unknown status Phase 1 Tolerance, Pharmacokinetics / Pharmacodynamics (PK / PD) and Immunogenicity of Pegylated Uric Acid Oxidase for Injection in Healthy Adults and Hyperuricemia Volunteers December 8, 2021 April 1, 2023
NCT02891031 Unknown status N/A The Effects of Rhus Coriaria L. on Serum Uric Acid Levels June 1, 2019 December 1, 2019
NCT02944214 Unknown status N/A Compare the Renal Protective Effects of Febuxostat and Benzbromarone in CKD Chinese Patients October 2016 December 2019
NCT04799925 Unknown status Hyperuricemia and Diabetic Nephropathy April 15, 2021 December 30, 2022
NCT01038947 Unknown status Phase 1 Safety and Efficacy Study of Intramuscular Uricase-PEG 20 December 2009 May 2010
NCT01021241 Unknown status Phase 1 Safety and Efficacy Study of Intravenous Uricase-PEG 20 October 2009 March 2010
NCT03691688 Unknown status The Long Term Effect of Low Dose Aspirin on Uric Acid in Chinese Patients With Coronary Artery Disease(AURORA) December 1, 2018 March 1, 2022
NCT03534037 Unknown status Phase 4 Urate Lowering Therapies and Left Ventricular Diastolic Dysfunction February 1, 2020 December 2021
NCT03200210 Unknown status Phase 4 Lowering-hyperuricemia Treatment on Cardiovascular Outcomes in Peritoneal Dialysis Patients July 11, 2017 December 31, 2022
NCT04953533 Unknown status Research and Development of a New Technology for Detection of Abnormal Excretion of Intestinal Uric Acid Involved in the Incidence of Gout July 6, 2021 December 31, 2023
NCT03218709 Unknown status Phase 4 The Intervention of Multi-vitamin With Minerals to Hyperuricemia January 2017 April 2018
NCT03425708 Unknown status Phase 4 Effect of Hyperuricaemia on Chronic Renal Disease January 1, 2017 December 31, 2018
NCT03473444 Unknown status Prevalence of Hyperuricemia in Pakistan March 1, 2018 April 15, 2018
NCT04072471 Withdrawn Post-Authorisation Safety Study of Lesinurad January 29, 2021 June 30, 2023
NCT03076684 Withdrawn Early Phase 1 Gender Differences in the Metabolic Effects of Uric Acid March 3, 2017 March 13, 2019
Disase is a (Disease Ontology)
DOID:0060158
Cross Reference ID (Disease Ontology)
MESH:D033461
Cross Reference ID (Disease Ontology)
NCI:C3961
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:271198001
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0740394
Exact Synonym (Disease Ontology)
Blood urate raized
Exact Synonym (Disease Ontology)
uricacidemia
HPO Human Phenotype ID (Human Phenotype Ontology)
HP:0002149
MedGen concept unique identifier (MedGen Concept name)
C0740394
MedGen unique identifier (MedGen Concept name)
149260
MeSH unique ID (MeSH (Medical Subject Headings))
D033461