gastroesophageal reflux disease
Information
- Disease name
- gastroesophageal reflux disease
- Disease ID
- DOID:8534
- Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT04711655 | Active, not recruiting | N/A | Antireflux Ablation of the Cardia Mucosa vs Placebo for the Treatment of Gastroesophageal Reflux Disease | March 1, 2021 | June 2024 |
| NCT05614752 | Active, not recruiting | Study to Evaluate the Improvement Effect on Subjective Symptom of FEXUCLUE Tab | July 6, 2022 | December 31, 2024 | |
| NCT02923362 | Active, not recruiting | Registry of Outcomes From AntiReflux Surgery | May 2016 | May 2025 | |
| NCT05886933 | Active, not recruiting | Study to Evaluate the Efficacy and Safety of FEXUCLUE Tablet | May 22, 2023 | December 31, 2024 | |
| NCT05365087 | Active, not recruiting | Transoral Fundoplication Prior to Sleeve Gastrectomy Versus RNY Gastric Bypass on GERD Symptoms in Bariatric Patients | March 1, 2018 | December 31, 2032 | |
| NCT01921686 | Active, not recruiting | Morphological Markers of Gastroesophageal Reflux Disease (GERD) | March 2013 | February 2025 | |
| NCT04408105 | Active, not recruiting | Survey Study on Barrett's Esophagus Screening | February 19, 2020 | September 2024 | |
| NCT00260572 | Active, not recruiting | Outcomes After Medical and Surgical Treatment of Gastroesophageal Reflux Disease | April 1999 | December 2050 | |
| NCT00206180 | Completed | Phase 4 | NEXIUM® in the Treatment of Moderate and Severe Erosive Esophagitis | June 2004 | August 2005 |
| NCT00214552 | Completed | Phase 3 | Evaluate the Effects on Asthma Control of Rabeprazole Given Twice Daily in Subjects With Asthma. | September 2002 | March 2005 |
| NCT00217347 | Completed | N/A | Evaluation of Efficiency of Esophageal Capsule Endoscopy in the Screening of Patients With Gastroesophageal Reflux Disease or Dyspepsia as Compared to Upper Endoscopy | September 2005 | July 2006 |
| NCT00220818 | Completed | Phase 1 | A Study to Evaluate the Effect of Lansoprazole on Infants With Gastroesophageal Reflux Disease. | January 2005 | July 2005 |
| NCT00251732 | Completed | Phase 4 | Role of Pain Modulation in GERD Patients Who Failed Standard Dose Proton Pump Inhibitors (PPI) | March 2005 | May 2010 |
| NCT00251745 | Completed | Phase 3 | Efficacy and Safety of Dexlansoprazole Modified Release Formulation to Treat Heartburn | December 2005 | May 2006 |
| NCT00251758 | Completed | Phase 3 | Safety and Efficacy of Dexlansoprazole Modified Release Formulation to Treat Heartburn | December 2005 | May 2006 |
| NCT00255190 | Completed | Phase 3 | Safety and Quality of Life Study of Dexlansoprazole Modified Release Formulation to Treat Heartburn | January 2006 | June 2008 |
| NCT00272701 | Completed | Phase 4 | Esomeprazole in PPI Failures - IMPROVE | December 2005 | February 2007 |
| NCT00287612 | Completed | N/A | Necessity of Esophageal Dissection During Laparoscopic Fundoplication | February 2006 | August 2009 |
| NCT00304421 | Completed | Phase 4 | Comparison of the Nighttime Effects of Two Different Drugs on Subjects With GERD | January 2004 | September 2007 |
| NCT00321984 | Completed | Phase 3 | Safety and Efficacy of Dexlansoprazole Modified Release Formulation to Treat Gastroesophageal Reflux Disease | June 2006 | December 2006 |
| NCT00324974 | Completed | Phase 3 | The Use of Lansoprazole to Treat Infants With Symptoms of Gastroesophageal Reflux | June 2006 | May 2007 |
| NCT00325676 | Completed | Phase 4 | Comparison of the Classical Healing Concept With the Complete Remission Concept After Treatment With Pantoprazole in Adult Patients With Erosive GERD (Gastroesophageal Reflux Disease) (BY1023/M3-342) | June 2006 | |
| NCT00343161 | Completed | Phase 4 | Symptom Adapted Therapy in GERD Patients | August 2006 | August 2007 |
| NCT00373334 | Completed | Phase 3 | Safety and Efficacy Study of Axid Use in Infants Suffering From Gastroesophageal Reflux Disease (GERD) | August 2006 | February 2008 |
| NCT00378898 | Completed | N/A | Feasibility of Placing Bravo PH Capsule in Proximal Esophagus | September 2006 | July 2009 |
| NCT00405119 | Completed | Phase 2 | A Study To Investigate The Effectiveness Of AH234844 (Lavoltidine) Compared With NEXIUM And Ranitidine. | May 2006 | March 2007 |
| NCT00410592 | Completed | Phase 4 | Evaluation of 24-Hour Intragastric pH Using Esomeprazole, Lansoprazole, and Pantoprazole in Hispanic Patients With GERD | October 2006 | May 2007 |
| NCT00414856 | Completed | Phase 1 | Effects of AFQ056 and Baclofen on Meal-Induced Gastroesophageal Reflux | August 2006 | |
| NCT05647668 | Completed | N/A | Laparoscopic Total vs Partial Fundoplication in Patients With Atypical Symptoms of Gastroesophageal Reflux Disease | March 1, 2018 | April 6, 2021 |
| NCT00476398 | Completed | Phase 4 | Evaluation of Patients With Non-cardiac Chest Pain | January 2006 | June 2009 |
| NCT00492622 | Completed | Phase 4 | Pharmacokinetics of Immediate-Release vs. Delayed-Release Omeprazole in Gastroparesis | June 2007 | December 2008 |
| NCT05405816 | Completed | N/A | Determination of Change in Reflux Disease After Sleeve Gastrectomy by Intraluminal Impedance and pH-meter | January 1, 2022 | September 1, 2022 |
| NCT00507377 | Completed | Foreshortened Esophagus and Its Surgical Therapy | September 2005 | July 2007 | |
| NCT00521703 | Completed | Phase 3 | Evaluation of Topical Lidocaine Spray as Adjuvant to Upper Gastrointestinal Endoscopy in Children | August 2007 | April 2008 |
| NCT00539240 | Completed | Phase 2/Phase 3 | Role of Pain Modulation in GERD Patients Who Failed Standard Dose PPI | April 2006 | November 2011 |
| NCT05193266 | Completed | Gastroesophageal Reflux Disease (GERD) Among ICU Survivors | January 14, 2022 | August 5, 2023 | |
| NCT00551473 | Completed | Phase 1 | Open-label Comparison of 24hr Gastric pH on Days 1, 2, 7 With Once-daily Administration of Lavoltidine 40 mg. | May 2007 | |
| NCT00561730 | Completed | Efficacy of Pantoprazole in Patients Older Than 12 Years Who Have Symptoms of Non-Erosive Reflux Disease (NERD) or Erosive Gastroesophageal Reflux Disease (eGERD) | October 2007 | December 2008 | |
| NCT05062876 | Completed | Phase 1 | A Study to Compare PK, PD and Safety of the AD-214 and AD-2141 | November 1, 2021 | March 29, 2022 |
| NCT04703868 | Completed | Phase 1 | A Study to Compare the Safety, Pharmacokinetics and Pharmacodynamics of YPI 011 to Rabeprazole in Healthy Adult Subjects | January 13, 2021 | June 14, 2021 |
| NCT04622358 | Completed | Phase 1 | A Study to Compare PK, PD and Safety of the AD-214-02 and Rabeprazole | December 5, 2020 | March 8, 2021 |
| NCT00618150 | Completed | N/A | Patient Education in Gastroesophageal Reflux Disease | September 1996 | |
| NCT00625495 | Completed | Phase 4 | Study Comparing the Effects of Esomeprazole Adminstered Orally and Intravenously on Basal and Pentrigastrin-stimulated Acid Output in Subjects With Symptoms of Gastroesophageal Reflux Disease (GERD) | September 2002 | November 2002 |
| NCT00626262 | Completed | Phase 4 | Open, Randomized, Two Way Crossover Study Comparing the Effect of Esomeprazole Adminstered Orally and iv | July 2002 | October 2002 |
| NCT00637845 | Completed | Phase 4 | Study Comparing Esomeprazole Magnesium 40mg Once Daily Versus Lansoprazole 30 mg Twice Daily in Symptom Control of Subjects With Persistent Gastrooesophageal Reflux Disease (GERD) | June 2002 | February 2003 |
| NCT00660660 | Completed | Phase 4 | Local Phase IV, Gastroesophageal Reflux Disease (GERD) Sleep Study US | April 2008 | July 2008 |
| NCT00674245 | Completed | Phase 2/Phase 3 | Effect of Pantoprazole 40mg Daily vs Placebo on Power Spectral Analysis of the Sleep EEG of Patients With GERD. | April 2008 | July 2010 |
| NCT00684190 | Completed | Phase 1 | Drug Interaction Study Between AZD3355 and Nexium | March 2008 | June 2008 |
| NCT00688402 | Completed | Phase 1 | Study to Compare Different Formulations of AZD3355 | April 2008 | June 2008 |
| NCT00698178 | Completed | Waist Circumference Versus Body Mass Index to Predict Severity of Gastroesophageal Reflux Disease | June 2008 | August 2009 | |
| NCT00728481 | Completed | Phase 2/Phase 3 | The Role Of Gastroesophageal Reflux Disease (GERD) in Eosinophilic Esophagitis | May 2008 | December 2010 |
| NCT00729339 | Completed | Phase 4 | Role of Mosapride in Patients With Gastroesophageal Reflux Disease | June 2008 | May 2009 |
| NCT00730106 | Completed | Endoscopic Findings in Patients With Typical Gastroesophageal Reflux Disease (GERD) Symptoms | May 2008 | December 2009 | |
| NCT04595500 | Completed | Relationship Between Gastroesophageal Reflux Disease and Dental Erosion | January 2009 | March 2011 | |
| NCT00734097 | Completed | Phase 4 | A Study of Nexium (Esomeprazole) 40 mg Once Daily in Subjects With Symptoms of Gastroesophageal Reflux Disease (GORD) After Treatment With a Full Dose of Proton Pump Inhibitor (PPI) | November 2007 | October 2008 |
| NCT00768196 | Completed | Prevalence of EED and Quality of Life Evaluated by Gastroesophageal Reflux Disease (GERD)-Q in Korean GERD Patients | September 2008 | February 2009 | |
| NCT00768443 | Completed | Symptoms and Management Strategies in Gastroesophageal Reflux Disease (GERD) | September 2008 | February 2009 | |
| NCT00786695 | Completed | N/A | Study Using Esomeprazole as a Diagnostic Test for GERD in Patients With NCCP | May 2006 | December 2009 |
| NCT00786773 | Completed | Survey to Describe Impact of Reflux Disease on Everyday Life in GERD Patients Before and After 4 Weeks Treatment. | October 2008 | June 2009 | |
| NCT00829738 | Completed | Efficacy of Pantoprazole 20/40 mg Once Daily (od) in Patients Older Than 12 Years Who Have Gastrointestinal Symptoms of Reflux Disease | January 2009 | June 2009 | |
| NCT00830115 | Completed | Pantoprazole 20/40 mg in the Treatment of Symptomatic Reflux Disease With Focus on Sleep Disorders | January 2009 | June 2009 | |
| NCT00842855 | Completed | Partial Response to PPI Treatment: The Cost to Society and the Burden to the Patient - a Study in France | February 2009 | November 2010 | |
| NCT00858858 | Completed | N/A | Clinical Studies on Bile Acids in Barrett's Esophagus | March 2009 | February 2015 |
| NCT00872755 | Completed | Phase 4 | Nissen and Gastroplasty in Gastroesophageal Reflux Disease (GERD) | January 2002 | December 2008 |
| NCT00885469 | Completed | PillCam® ESO 2 in Esophageal Pathologies | December 2007 | April 2009 | |
| NCT00886197 | Completed | Diagnostic Efficacy of Narrow Band Imaging in Patients With Gastroesophageal Reflux Disease | September 2007 | April 2009 | |
| NCT00901004 | Completed | The Clinical Significance of Minimal Change in Reflux Esophagitis Based on the Gastroesophageal Reflux Disease Questionnaire | April 2009 | September 2009 | |
| NCT00914342 | Completed | Prevalence and Impact in Work Productivity of Gastroesophageal Reflux Disease (GERD) in Primary Care Patients With Upper Gastrointestinal (GI) Symptoms Using GerdQ | July 2009 | December 2009 | |
| NCT04568772 | Completed | Phase 1 | Study to Evaluate the Influence of Tegoprazan on the Pharmacokinetics of Proguanil in Healthy Volunteers | November 25, 2020 | August 3, 2021 |
| NCT00926276 | Completed | Phase 4 | The Role of Anti-Reflux Surgery for Gastroesophageal Reflux Disease in Premature Infants With Bronchopulmonary Dysplasia | June 2009 | May 2013 |
| NCT04494243 | Completed | Phase 1 | A Study to Compare PK, PD and Safety of the AD-214 10/600mg and Rabeprazole | August 28, 2020 | January 15, 2021 |
| NCT00951093 | Completed | Gastroesophageal Reflux Disease (GERD) Before and After Gastric Bypass | March 2007 | December 2012 | |
| NCT00963144 | Completed | Diagnosis and Response to Treatment Using a Reliable Gastroesophageal Reflux Disease (GERD) Questionnaire: An In Clinical Practice Study | July 2009 | November 2009 | |
| NCT00978016 | Completed | Phase 2 | A Study to Evaluate the Efficacy and Safety of Arbaclofen Placarbil (XP19986) as Adjunctive Therapy in Subjects With Gastroesophageal Reflux Disease (GERD) | September 2009 | December 2010 |
| NCT00998244 | Completed | N/A | Study to Evaluate the Effect of a Very Low Carbohydrate Diet on Gastroesophageal Reflux Disease | September 2009 | December 2011 |
| NCT01005251 | Completed | Phase 2 | Investigate the Effect of Different Doses of Lesogaberan (AZD3355) as add-on to PPI in GERD Patients With Partial Response to PPI | October 2009 | July 2010 |
| NCT01020890 | Completed | Prevalence of Gastroesophageal Reflux Disease in Primary Care Patients With Upper Gastrointestinal Symptoms | November 2009 | April 2010 | |
| NCT01026103 | Completed | N/A | Tri Staple Technology Stapler Used in Gastric Bypass | January 2010 | March 2011 |
| NCT01027975 | Completed | N/A | Comparison of Laparoscopic Nissen Versus Thal Fundoplication in Children | July 1998 | |
| NCT01039558 | Completed | N/A | The Effect of Lansoprazole in Combination With Ecabet Sodium for Gastroesophageal Reflux Disease | December 2009 | March 2011 |
| NCT01041105 | Completed | Gastric Bypass After Previous Anti-reflux Surgery | December 2008 | December 2009 | |
| NCT01043185 | Completed | Phase 2 | A Study to Estimate Effect of 4 Different Doses of AZD3355 on Reflux Episodes, Which Patients With Gastroesophageal Reflux Disease (GERD) May Experience | December 2009 | May 2010 |
| NCT01053585 | Completed | N/A | Structure and Function of the Gastro-esophageal Junction | February 2007 | May 2011 |
| NCT01058070 | Completed | N/A | An Observational Clinical Feasibility Study of the Magnetic Esophageal Sphincter | February 2007 | August 2013 |
| NCT01065649 | Completed | Phase 3 | Effect of Nortriptyline in Cortical Representation of Heartburn in Nonerosive Reflux Disease (NERD) Patients | January 2010 | June 2010 |
| NCT00057174 | Completed | N/A | Economic Impact of Guidelines for Gastroesophageal Reflux Disease | June 2004 | |
| NCT04152798 | Completed | N/A | Approach to Hiatal Hernia Repair Based on Collagen Study | January 1, 2014 | September 20, 2019 |
| NCT01095133 | Completed | Phase 1 | Do Acid Sensing Ion Channels Contribute to Heartburn? | March 2010 | September 2011 |
| NCT01099735 | Completed | Effect of Continuous Positive Airway Pressure (CPAP) on Lower Esophageal Sphincter Pressure in Morbidly Obese Patients | January 2010 | June 2012 | |
| NCT03904472 | Completed | N/A | Cognitive Behavioral Therapy for Insomnia (CBTI) in GERD Patients With Insomnia | April 15, 2019 | March 25, 2022 |
| NCT01110811 | Completed | N/A | Transoral Incisionless Fundoplication (TIF) Versus Sham for Treatment of Gastroesophageal Reflux Disease (GERD) | April 2010 | December 2018 |
| NCT01118585 | Completed | N/A | Transoral Incisionless Fundoplication (TIF) Registry Study for Treatment of Gastroesophageal Reflux Disease (GERD) | May 2010 | December 2018 |
| NCT01126034 | Completed | N/A | Improving Metoclopramide Prescribing Practices at Penn Through a Physician-targeted Intervention | March 2007 | April 2008 |
| NCT03871426 | Completed | Manual Therapy Effects on Upper and Lower Esophageal Sphincter Pressures | March 18, 2019 | June 13, 2019 | |
| NCT03848494 | Completed | True Short Esophagus in Gastroesophageal Reflux Disease | January 1, 2004 | December 31, 2018 | |
| NCT01136980 | Completed | N/A | Randomized EsophyX Versus Sham / Placebo Controlled TIF Trial: The RESPECT Study | April 2011 | March 2018 |
| NCT01149395 | Completed | Phase 1 | Can E-cadherin Found in Tissue/Blood be Valuable in Identifying & Monitoring Patients With Post-proton Pump Inhibitor (PPI)-Responsive Heartburn | June 2010 | April 2012 |
| NCT01161602 | Completed | Phase 2 | A Study to Evaluate the Safety, Tolerability and Pharmacodynamics of Pumosetrag in Patients With Gastroesophageal Reflux Disease (GERD) | May 2011 | |
| NCT03692455 | Completed | N/A | Clinico-functional Evaluation of GERD: Comparative Study of Vertical Sleeve Gastrectomy vs Roux-en-Y Gastric Bypass | October 19, 2016 | August 13, 2018 |
| NCT01200550 | Completed | The Study to Describe Symptom Control and Impact on Daily Life in Gastroesophageal Reflux Disease (GERD) Patients | September 2010 | November 2011 | |
| NCT01204931 | Completed | Can We Predict Who Has Gastroesophageal Reflux Disease (GERD)? | November 2010 | June 2015 | |
| NCT01212614 | Completed | N/A | Measurement of Gastric Secretion by MRI Under Inhibition by ProtonPump Inhibitors in Healthy Subjects & in GERD Patients | October 2010 | September 2012 |
| NCT03616119 | Completed | Gastroesophageal Reflux Disease in Azerbaijan | January 1, 2018 | September 1, 2019 | |
| NCT01215305 | Completed | A Cross-sectional Study on the Prevalence and Extraesophageal Symptoms of Gastroesophageal Reflux Disease(GERD) in Patients With Upper GI Symptoms, Visiting the Outpatient Departments of Peripheral Hospitals in Greece | October 2010 | March 2011 | |
| NCT03516188 | Completed | Phase 2/Phase 3 | Efficacy of Gaviscon-Advance® in Suppressing Post-supper Acid-pocket and Night-time Acid-reflux in Obese Participants | July 2016 | June 2017 |
| NCT01260935 | Completed | N/A | Comparison of Laparoscopic Hill and Laparoscopic Nissen Anti-Reflux Procedures | November 2002 | November 2010 |
| NCT01262755 | Completed | Temple Registry for the Investigation of African American Gastrointestinal Disease Epidemiology | April 2010 | January 2015 | |
| NCT01321294 | Completed | N/A | Laparoscopic Nissen Versus Toupet Fundoplication: Objective and Subjective Results of a Prospective Randomized Trial | ||
| NCT01324791 | Completed | N/A | Laparoscopic Antireflux Surgery Versus Endoscopic Full-thickness Gastroplication for Gastroesophageal Reflux Disease (GERD) | ||
| NCT01338077 | Completed | Phase 3 | Efficacy and Safety of Sodium Alginate Oral Suspension to Treat Non-erosive Gastro-esophageal Reflux Disease | October 2010 | January 2012 |
| NCT03299985 | Completed | N/A | Diaphragmatic Myofascial Release in Gastroesophageal Reflux Disease | October 5, 2017 | March 15, 2018 |
| NCT01381991 | Completed | N/A | The Efficacy of i-Scan for Detecting Reflux Esophagitis | July 2010 | June 2011 |
| NCT01390714 | Completed | Phase 1 | Pharmacodynamic and Pharmacokinetic Study of E3710 Following Oral Administration to Healthy, Male, Japanese Subjects | July 2011 | October 2011 |
| NCT03284177 | Completed | Phase 2 | A Trial of C13-CAC Breath Test in PPI Resistant GERD Patients | October 31, 2017 | December 4, 2018 |
| NCT01397084 | Completed | Phase 4 | To Assess the Efficacy of Esomeprazole 20mg Once Daily in Subjects Who Still Had Heartburn After Receiving Rabeprazole | August 2011 | January 2012 |
| NCT01400945 | Completed | Phase 3 | Efficacy Study of AGSPT201 Tablet to Treat Gastroesophageal Reflux Disease | December 2009 | September 2011 |
| NCT03128736 | Completed | Phase 4 | Comparing Clinical Efficacy of One-Week Dual Delayed-Release Dexlansoprazole and Esomeprazole for GERD Grade A and B | April 1, 2014 | March 30, 2016 |
| NCT01432392 | Completed | Symptom Control and Impact on Daily Life in Patients With Gastroesophageal Reflux Disease | September 2011 | April 2012 | |
| NCT03069963 | Completed | Phase 1 | PH Metry Study to Compare the Antacid Activity of Z0063 Versus Gaviscon Double Action Tablets, in Healthy Adult Subjects | February 24, 2017 | April 23, 2017 |
| NCT03065816 | Completed | Phase 1 | Scintigraphy Study to Compare the Antireflux Activity of the Z0063 Versus Gaviscon Double Action Tablets, in Healthy Adult Subjects | February 9, 2017 | May 2, 2017 |
| NCT01472939 | Completed | Phase 2 | Selective 5-HT4 Receptor Agonist and Proton Pump Inhibitor (PPI) in Subjects With Gastroesophageal Reflux Disease (GERD) | February 27, 2012 | May 14, 2013 |
| NCT03053609 | Completed | Gastroesophageal Reflux and Cardiorespiratory Problems | January 2006 | December 2016 | |
| NCT01489735 | Completed | The Use of International GerdQ Questionnaire | February 2012 | June 2012 | |
| NCT03037606 | Completed | Phase 4 | Comparison of the Effect of Rabeprazole 50 mg DDR Capsules and 20 mg Enteric-coated Tablets | August 1, 2017 | December 11, 2018 |
| NCT01536457 | Completed | Reflux Disease Therapy in the Management of Childhood Asthma-data Entry and Analysis Only | July 2011 | January 2013 | |
| NCT02958046 | Completed | Phase 4 | The Efficacy of Lansoprazole and Domperidone Combination on Intragastric and Intraesophageal Acidity | January 2014 | August 2015 |
| NCT02930824 | Completed | N/A | Genotype-supported Versus Conventional Proton Pump Inhibitor Dosing | December 2016 | July 17, 2019 |
| NCT01576289 | Completed | Analysis of Biopsies From the Upper Gastrointestinal Tract | November 2011 | May 2012 | |
| NCT01578642 | Completed | Phase 2 | Feasibility Study for Evaluating the Effect of Electrical Stimulation on Lower Esophageal Sphincter Pressure and Esophageal Acid Exposure in Patients With Gastroesophageal Reflux Disease | September 2010 | May 2013 |
| NCT01601379 | Completed | Observational Study (This Means That no Drug is Tested) in Patients Suffering of Gastroesophageal Reflux Disease. | June 2010 | June 2011 | |
| NCT02893709 | Completed | N/A | Factors Influencing the Human Gut Microbiome Profile in Multi-ethnic Groups of the Singapore Community (FAMES) | June 2015 | July 2016 |
| NCT02890979 | Completed | N/A | Swallowable Sponge Cell Sampling Device and Next Generation Sequencing in Detecting Esophageal Cancer in Patients With Low or High Grade Dysplasia, Barrett Esophagus, or Gastroesophageal Reflux Disease | August 3, 2016 | October 10, 2017 |
| NCT01642602 | Completed | Phase 2 | Safety and Efficacy of Dexlansoprazole Delayed-Release Capsules in Treating Symptomatic Non-Erosive Gastroesophageal Reflux Disease in Adolescents | July 2012 | January 2014 |
| NCT01642615 | Completed | Phase 2 | Safety and Efficacy of Dexlansoprazole Delayed-Release Capsules for Healing of Erosive Esophagitis and Maintenance of Healed Erosive Esophagitis and Relief of Heartburn in Adolescents | July 2012 | November 2014 |
| NCT01682265 | Completed | N/A | Stretta In Reflux Uncontrolled by IPP | March 26, 2012 | November 27, 2018 |
| NCT02873689 | Completed | Phase 3 | Efficacy and Safety of Dexlansoprazole on Heartburn Relief in Chinese Patients | December 27, 2016 | April 19, 2018 |
| NCT02860624 | Completed | Phase 3 | Ilaprazole for the Treatment of Gastroesophageal Reflux Disease (GERD) in Chinese Patients | December 2011 | |
| NCT01733810 | Completed | N/A | The Role of HIF-2a in the Pathogenesis of Reflux Esophagitis | February 1, 2013 | July 31, 2019 |
| NCT01742377 | Completed | Minimal Change Esophagitis by i-Scan Endoscopy in Dyspeptic Patients | February 2010 | July 2014 | |
| NCT01753128 | Completed | Phase 3 | Efficacy of Imipramine for Treatment of Patients With Esophageal Hypersensitivity/ Functional Heartburn | December 2012 | September 2013 |
| NCT01776827 | Completed | Long-term Outcome of Laparoscopic Hiatal Hernia Repair With or Without Alloderm Mesh at a University Hospital | May 22, 2012 | February 11, 2015 | |
| NCT01777867 | Completed | Cough Reflex Sensitivity and Bronchial Hyper-responsiveness | December 2012 | February 2016 | |
| NCT02706938 | Completed | N/A | Impact of Head of Bed Elevation in Symptoms of Patients With Gastroesophageal Reflux Disease | April 8, 2016 | November 15, 2017 |
| NCT01798212 | Completed | N/A | Prospective Trial on the Clinical Feasibility of a New Full Thickness Endoscopic Plication Device for Patients With GERD. | August 2013 | December 2016 |
| NCT01806220 | Completed | N/A | Laryngeal and Esophageal EGF-r Expression in Patients With Reflux Laryngitis | January 2004 | December 2007 |
| NCT01818570 | Completed | Phase 1 | A Study of Local Effect and Safety of a Single PPC-5650 Dose on Reflux Pain During Pain Stimulation in the Esophagus | January 2013 | January 2014 |
| NCT02685436 | Completed | Phase 4 | Role of Pepsin Assay in Wheezy Infants | March 2013 | May 2015 |
| NCT01844440 | Completed | N/A | Diagnostic of Transient Lower Esophageal Sphincter Relaxation With Combined Impedance and High Resolution Manometry in Patients With GERD | April 2013 | January 2014 |
| NCT01869491 | Completed | Phase 3 | Compound Sodium Alginate Double Action Chewable Tablet Symptomatic Relief Study | June 2013 | May 2014 |
| NCT01872897 | Completed | Phase 3 | Compound Sodium Alginate Double Action Chewable Tablets 4-hour Esophageal pH Study in GERD Patients | June 2013 | December 2013 |
| NCT01878526 | Completed | Phase 3 | Gastroesophageal Reflux Treatment in Scleroderma | June 2013 | January 2016 |
| NCT01882088 | Completed | Phase 4 | Phase IV Study of the Impact of Dietary Fibers on Symptoms and Esophageal Motility in Patients With Non-erosive GERD | April 2012 | December 2016 |
| NCT01954667 | Completed | Anthropometric Measures and Severity of Gastroesophageal Reflux Disease | January 2012 | August 2013 | |
| NCT02685150 | Completed | N/A | Endoscopic Tri-Modal Imaging to Distinguish Functional Dyspepsia From Reflux Disease | January 2016 | June 2018 |
| NCT02060500 | Completed | N/A | Cardiaplication: A Novel Antireflux Operation | June 2012 | June 2015 |
| NCT02072447 | Completed | Early Phase 1 | Absolute Bioavailability of YH4808 With Accelerator Mass Spectrometry(AMS)-Based Microdose Study | March 2014 | April 2014 |
| NCT02096458 | Completed | Phase 1 | Sensory Evaluation of Dexlansoprazole Delayed-Release Orally Disintegrating Tablets | February 2014 | February 2014 |
| NCT02100189 | Completed | N/A | Esophageal Cytology With FISH in Detecting Esophageal Cancer | February 2014 | December 2015 |
| NCT02135107 | Completed | Phase 3 | A Double-blind Comparative Study of the Efficacy and Safety of E3810 10mg Once and Twice Daily in Maintenance Therapy for PPI Resistant Gastroesophageal Reflux Disease Patients | September 2013 | June 2016 |
| NCT02154659 | Completed | N/A | The Difference of Reflux Pattern Between the Patients Who Have Postprandial Reflux Symptoms | June 2014 | December 7, 2015 |
| NCT02186652 | Completed | Phase 1 | PK Study With Pantoprazole in Obese Children and Adolescents | June 4, 2014 | September 13, 2015 |
| NCT02200055 | Completed | N/A | Using Electrical Bioimpedance Assessments to Estimate Perioperative Total Body Water and Postoperative Fluid Need | May 2012 | July 2015 |
| NCT02637557 | Completed | Phase 2 | A Trial of IW-3718 for 8 Weeks in Patients With Symptomatic Gastroesophageal Reflux Disease (GERD) | March 1, 2016 | April 26, 2017 |
| NCT02226484 | Completed | Phase 1 | Can Quercetin Increase Claudin-4 and Improve Esophageal Barrier Function in GERD? | August 2014 | June 2016 |
| NCT02579460 | Completed | N/A | Reflux-Induced Oxidative Stress in Barrett's Esophagus: Response, Repair, and Epithelial-Mesenchymal-Transition | November 2015 | November 2017 |
| NCT02558049 | Completed | N/A | Should I Continue Taking My Acid Reflux Medication? Development and Pilot Testing of a Patient Decision Aid | November 2015 | December 2016 |
| NCT02486263 | Completed | N/A | Neonatal Gastro-Esophageal Reflux Disease (GERD) Management Trial | December 2012 | March 31, 2020 |
| NCT02336100 | Completed | N/A | Diagnostic Value of Flexible Spectral Imaging Color Enhancement (FICE) Plus Probe-based Confocal Laser Endomicroscopy (pCLE) for Minimal Change Esophageal Reflux Disease (MERD) Diagnosis | June 2011 | June 2012 |
| NCT02351960 | Completed | Phase 4 | Dexlansoprazole in Asian Participants With Gastroesophageal Reflux Disease | March 19, 2015 | July 13, 2016 |
| NCT02429830 | Completed | N/A | LINX Reflux Management System in Subjects With GERD Who Have Previously Undergone a Laparoscopic Sleeve Gastrectomy | April 5, 2017 | June 8, 2021 |
| NCT02384551 | Completed | N/A | Dietary Carbohydrate and GERD in Veterans | January 25, 2016 | July 1, 2022 |
| NCT00132496 | Completed | Phase 2 | Treatment of Gastroesophageal Reflux Disease in 12-16 Year Old Patients With Rabeprazole | August 2005 | July 2006 |
| NCT00164840 | Completed | Phase 3 | Symptomatic Gastroesophageal Reflux Disease: Double Blind Randomized Controlled Study of On-demand Therapy Versus Maintenance Therapy | May 2003 | November 2008 |
| NCT00165022 | Completed | Development of a Novel Disease-Specific Quality of Life Questionnaire for Gastroesophageal Reflux Disease (GERD) Patients in Chinese Population | September 2003 | October 2006 | |
| NCT00165841 | Completed | Phase 2 | Maintenance Intermittent Therapy for Symptomatic GERD Patients | October 2004 | June 2008 |
| NCT00174928 | Completed | Phase 1 | A Study to Evaluate the Effect of Lansoprazole on Hospitalized Neonates With Gastroesophageal Reflux Disease | May 2005 | August 2005 |
| NCT06106022 | Completed | Phase 1 | A Study to Evaluate Vonoprazan in Children Who Have Symptomatic Gastroesophageal Reflux Disease | November 1, 2023 | April 29, 2024 |
| NCT00200642 | Completed | N/A | Evaluation of the Efficiency of Radiofrequency in the Treatment of Gastroesophageal Reflux Disease | December 2003 | October 2007 |
| NCT04306380 | Enrolling by invitation | Transoral Incisionless Fundoplication Database Repository (TIF) | May 20, 2020 | December 31, 2040 | |
| NCT03853772 | Enrolling by invitation | The Johns Hopkins Heartburn Center Registry | April 27, 2019 | December 2025 | |
| NCT05216133 | Enrolling by invitation | Biomarkers of Airway Disease, Barrett's and Underdiagnosed Reflux Noninvasively (BADBURN) | March 22, 2023 | July 2024 | |
| NCT05937204 | Not yet recruiting | N/A | Nursing Teaching Scheme for Patients With Gastroesophageal Reflux Disease | July 1, 2023 | July 1, 2024 |
| NCT05422404 | Not yet recruiting | N/A | Anti-Reflux Mucosal Ablation(ARMA) and Anti-Reflux Mucosectomy(ARMS) in Gastroesophageal Reflux Disease | June 30, 2022 | July 31, 2025 |
| NCT06348420 | Not yet recruiting | N/A | Anti-reflux Mucosal Valvuloplasty Versus PPIs for GERD Treatment | April 10, 2024 | August 13, 2027 |
| NCT04763993 | Not yet recruiting | N/A | Reflux Disease After Gastric Bypass Versus Sleeve Gastrectomy in Morbid Obese Patients: an Italian Study | May 1, 2024 | May 1, 2025 |
| NCT06304142 | Not yet recruiting | N/A | Effect of Lidocaine Block on Gastroesophageal Reflux Disease | March 2024 | June 2024 |
| NCT06153901 | Not yet recruiting | N/A | Endoloop Mediated Cardioplication to Treat Gastroesophageal Reflux Disease | December 10, 2023 | December 10, 2024 |
| NCT06319521 | Not yet recruiting | N/A | Stellate Ganglion Block on Gastroesophageal Reflux Disease | March 2024 | December 2024 |
| NCT06106100 | Not yet recruiting | N/A | Anti-reflux Mucosal Ablation Therapy Randomized Sham Control Trial for Gastroesophageal Reflux Disease | March 2024 | October 2027 |
| NCT00574327 | Recruiting | Progression of Gastroesophageal Reflux Disease and Barrett's Esophagus and the Creation of a Barrett's Registry | January 2006 | January 2029 | |
| NCT01696734 | Recruiting | Phase 3 | Domperidone in Treating Patients With Gastrointestinal Disorders | October 23, 2012 | October 31, 2025 |
| NCT04036942 | Recruiting | N/A | Antireflux Ablation Therapy (ARAT) Vs Antireflux Mucosectomy (ARMS) In The Management Of Gastroesophageal Reflux Disease | July 15, 2019 | December 1, 2022 |
| NCT04094402 | Recruiting | Epi-GERD Study: Epidemiological Evaluation in Patients With Gastro-Esophageal Reflux Disease (GERD) | June 4, 2019 | July 2024 | |
| NCT04255693 | Recruiting | N/A | Real-life Study of Changes of Gastroesophageal Reflux Disease Manifestations Due to Behavioural and Diet Adherence | January 31, 2020 | December 31, 2025 |
| NCT05701540 | Recruiting | Phase 4 | A Study to Evaluate the Efficacy and Safety of Tegoprazan in GERD Patients With Nighttime Heartburn | March 24, 2023 | December 31, 2024 |
| NCT05660122 | Recruiting | A Study to Evaluate the Improvement Effect on Subjective Symptom of FEXUCLUE Tab | November 11, 2022 | October 31, 2023 | |
| NCT05514769 | Recruiting | N/A | Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty Versus Esophagogastric Anastomosis for Gastric Cancer | January 1, 2021 | December 31, 2024 |
| NCT05107219 | Recruiting | Phase 1 | GCC Agonist Signal in the Small Intestine | November 30, 2022 | February 1, 2025 |
| NCT05452980 | Recruiting | N/A | Sleeve Gastrectomy With Reestablishment of the Acute Angle of His (SG-REACH) in Obese Patients | June 1, 2022 | December 30, 2025 |
| NCT03776669 | Recruiting | N/A | Laparoscopic Sleeve Gastrectomy With or Without Hiatal Hernia Repair in Morbidly Obese Patients | January 9, 2019 | December 17, 2024 |
| NCT01580631 | Suspended | Narrow Band Imaging Project on Barrett's Esophagus | October 2012 | December 2025 | |
| NCT02227927 | Temporarily not available | Treatment Use of Domperidone for Gastroparesis | |||
| NCT01199679 | Terminated | N/A | Rubber Band Ligation and Mucosectomy for Gastroesophageal Reflux Disease (GERD) | June 2011 | March 2013 |
| NCT01404832 | Terminated | Phase 4 | The Frequency of Eosinophilic Esophagitis in Patients With Heartburn That is Refractory to Proton Pump Inhibitors | October 2007 | May 2010 |
| NCT00393653 | Terminated | N/A | Prescription Methods Assessment Project (PMAP) | October 2006 | May 2007 |
| NCT00536328 | Terminated | What is the Predictive Value of the Reflux Impact Scale | October 2007 | June 2008 | |
| NCT01078064 | Terminated | Gastric Accommodation and Gastroesophageal Reflux | March 2010 | November 2010 | |
| NCT01572974 | Terminated | Quality of Life in Barrett's Esophagus and Gastro-Esophageal Reflux Disease | January 2010 | December 2017 | |
| NCT00200044 | Terminated | N/A | An Evaluation of the Medtronic Gatekeeper System in the Treatment of SUBJECTS With Gastroesophageal Reflux Disease (GERD) | December 2002 | June 2008 |
| NCT01370863 | Terminated | Phase 2 | An Explorative Trial to Evaluate the Pharmacodynamic Effect of SPD557 on Reflux Parameters in Refractory GERD Patients | December 2, 2010 | May 29, 2012 |
| NCT02211105 | Terminated | Registry to Compare Two Surgical Treatments for GERD | July 2014 | April 2017 | |
| NCT00449813 | Terminated | Phase 4 | The CONQUEST-Study. Evaluation of Clinical Endpoints for Treatment-induced Changes in GERD-related Symptoms (BY1023/NL511) | March 2007 | November 2008 |
| NCT02401035 | Terminated | Phase 4 | PREA, PK And Safety PASS Study Of IV Pantoprazole In Pediatric Subjects | May 9, 2017 | June 18, 2021 |
| NCT01212835 | Terminated | N/A | Effect of RING on Gastroesophageal Reflux (GERD) After RYGBP | October 2010 | January 2014 |
| NCT00954070 | Terminated | Detection of Minimal Change Esophagitis Using Confocal Laser Endomicroscopy | August 2009 | April 2012 | |
| NCT00730665 | Terminated | Phase 2 | Efficacy And Safety Of PF-00885706 For The Relief Of Symptoms In Subjects With Gastro-esophageal Reflux Disease (GERD) | January 2008 | October 2008 |
| NCT02762487 | Terminated | N/A | RELIEF Europe Study | November 2015 | February 2017 |
| NCT03467438 | Unknown status | Phase 4 | Efficacy of Zinc L-carnosine in Maintaining Remission of Gastroesophageal Reflux Disease | November 22, 2018 | April 1, 2021 |
| NCT02500264 | Unknown status | N/A | The Effect of Non Invasive Electrical Stimulation Therapy on Gastroesophageal Reflux Disease (GERD) Symptoms - Proof of Concept Study | August 2015 | October 2018 |
| NCT02255071 | Unknown status | N/A | The Efficacy of Neiguan (P6 Point) Acupressure in Patients With Gastroesophageal Reflux Disease (GERD) | June 2014 | December 2015 |
| NCT01822106 | Unknown status | Phase 4 | Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD) | February 2013 | |
| NCT01782118 | Unknown status | Phase 4 | LGG for Prevention of Infectious Complications During PPI Treatment in Children | February 2013 | July 2014 |
| NCT02759393 | Unknown status | Phase 4 | Treatment Effect Between Dexlansoprazole and Double-dose Lansoprazole in Obesity Patients With Reflux Esophagitis | October 2015 | September 2017 |
| NCT02793479 | Unknown status | Radiofrequency Ablation in Patients With Barrett's Esophagus | March 1, 2017 | December 2021 | |
| NCT02818309 | Unknown status | Phase 2 | Lesogaberan in Chinese Patients With Refractory Reflux Symptoms | January 2015 | December 2017 |
| NCT01641887 | Unknown status | Decision Aid for Gastroesophageal Reflux Disease Management | January 2014 | December 2016 | |
| NCT01634672 | Unknown status | Prevalence of Gastroesophageal Reflux Disease in Peritoneal Dialysis and Hemodialysis Patients | July 2010 | October 2012 | |
| NCT01574339 | Unknown status | Phase 3 | Effect of Long-Term Electrical Stimulation on LES Pressure and Esophageal Acid Exposure in Patients With GERD | August 2011 | July 2016 |
| NCT02934152 | Unknown status | Phase 4 | Symptom Assessment for Patients With Gastro-esophageal Reflux Disease Receiving Helicobacter Pylori Eradication | October 2016 | September 2019 |
| NCT02984930 | Unknown status | N/A | Effect of Proton Pump Inhibitor and Mosapride on Acid Pocket in Gastroesophageal Reflux Disease | December 2016 | July 2018 |
| NCT01504971 | Unknown status | Narrow-band Imaging, Autofluorescence Imaging and Gastroesophageal Reflux Disease | January 2011 | December 2016 | |
| NCT03068572 | Unknown status | Diagnostic Value of Linked Color Imaging for Minimal Change Esophagitis in Nonerosive Reflux Esophagitis and GERD | January 15, 2017 | December 30, 2017 | |
| NCT01453985 | Unknown status | N/A | Full-Thickness-Gastroplication For The Treatment Of Gastroesophageal Reflux Disease GERD | ||
| NCT03223116 | Unknown status | N/A | Radiofrequency Energy Delivery for Gastroesophageal Reflux Disease | July 1, 2015 | July 1, 2018 |
| NCT02277886 | Unknown status | Phase 4 | Esomeprazole Plus Alginate vs. Esomeprazole Alone for Treatment of Nighttime Reflux Symptom and Sleep Disturbances | November 2014 | June 2016 |
| NCT01249482 | Unknown status | Symptom Assessment for GERD Patients Receiving H. Pylori Eradication | September 2010 | August 2012 | |
| NCT01128608 | Unknown status | N/A | The Effect of High PCO2 Solution on Esophageal Acid Sensation | September 2009 | November 2010 |
| NCT01128582 | Unknown status | Phase 3 | Effect of Rozerem on the Perception of GERD Symptoms in Patients With Chronic Insomnia. | March 2009 | December 2011 |
| NCT01107938 | Unknown status | Phase 2 | Ilaprazole for the Treatment of Gastroesophageal Reflux Disease (GERD) in Chinese Patients | May 2010 | |
| NCT04129008 | Unknown status | Phase 4 | GaStroEsophageal effeCt of indobUfen Versus aspiRin in Patients Undergoing Dual antiplatElet Therapy | October 17, 2019 | December 31, 2020 |
| NCT01089959 | Unknown status | Phase 2/Phase 3 | Effect of Esomeprazole 40 mg.Daily for 7 Days on Acid Reflux and Related Arousals During Sleep in Patients With GERD | March 2010 | March 2012 |
| NCT04696783 | Unknown status | Phase 3 | The Effect of PPI in Preventing Gastroesophageal Reflux Disease of Seafarers | July 2021 | November 2021 |
| NCT00564590 | Unknown status | Phase 1/Phase 2 | SThe Effects of Melatonin on GERD Symptoms | October 2008 | January 2011 |
| NCT00539786 | Unknown status | N/A | The Proton Pump Inhibitor (PPI) Test for the Extraesophageal Manifestation of GERD | March 2006 | |
| NCT00498082 | Unknown status | Determinants of Efficacy of EsophyX Treatment in Gastro-Esophageal Reflux Disease | September 2007 | September 2008 | |
| NCT00480285 | Unknown status | Phase 3 | A Prospective Randomized Trial Comparing Laparoscopic Nissen Against Anterior Partial Fundoplication in Treating Gastroesophageal Reflux Disease Among Chinese Patients | November 2006 | November 2011 |
| NCT02457104 | Unknown status | The Effect of PPI Therapy on Weight, Gut Microbiome, and Expression of GPR41 and GPR43 | June 2015 | December 2021 | |
| NCT00591877 | Withdrawn | N/A | A Study to Evaluate the Role of Alternative Medicine in Difficult to Treat GERD Patients | December 2012 | January 2015 |
| NCT00915616 | Withdrawn | Phase 3 | The Potential Therapeutic Effect of Melatonin in Gastro-Esophageal Reflux Disease | ||
| NCT00928161 | Withdrawn | N/A | Reflux Disease in Head and Neck Cancer Patients Undergoing Radiation Therapy | November 2012 | |
| NCT04311541 | Withdrawn | A Study of Dexlansoprazole Modified Release (MR) in Gastroesophageal Reflux Disease (GERD) Participants in the Russian Federation | March 15, 2020 | January 31, 2022 | |
| NCT04052581 | Withdrawn | Prospective Collection of Outcome Data Post POEM-TIF Procedure | July 2023 | July 26, 2023 | |
| NCT01391715 | Withdrawn | Phase 3 | Double-dose Rabeprazole Accelerates and Sustains the Control of Symptoms in Patients With NERD | August 2011 | December 2012 |
| NCT01471925 | Withdrawn | Phase 3 | Study Comparing Esomeprazole Associated With Sodium Bicarbonate From Eurofarma and Esomeprazole in Treatment of Gastroesophageal Reflux Disease ESOBIC | ||
| NCT01479231 | Withdrawn | Phase 1/Phase 2 | Predictors of Proton Pump Inhibitor (PPI) Response in Eosinophilic Esophagitis | March 2012 | March 2012 |
| NCT06215742 | Withdrawn | N/A | Clinical Effect of Stellate Ganglion Block on Gastroesophageal Reflux Disease | January 30, 2024 | May 15, 2024 |
| NCT01710462 | Withdrawn | Phase 3 | Clinical Study, Multicenter, Randomized With 2 Arms of Pantoprazole + Domperidone and Pantoprazole Isolated at the Gastroesophageal Reflux Disease | August 2013 | |
| NCT00584675 | Withdrawn | N/A | Nasopharyngeal 24 Hour pH Monitoring in Health Adult Volunteers | February 2007 | February 2008 |
| NCT02039869 | Withdrawn | N/A | Confocal Endomicroscopy for Non-Erosive Reflux Disease (CE NERD) |
- Disase is a (Disease Ontology)
- DOID:77
- Cross Reference ID (Disease Ontology)
- ICD10CM:K21.9
- Cross Reference ID (Disease Ontology)
- ICD9CM:530.81
- Cross Reference ID (Disease Ontology)
- MESH:D005764
- Cross Reference ID (Disease Ontology)
- MIM:109350
- Cross Reference ID (Disease Ontology)
- NCI:C26781
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:235595009
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0017168
- Exact Synonym (Disease Ontology)
- Acid reflux
- Exact Synonym (Disease Ontology)
- Gastresophageal reflux
- Exact Synonym (Disease Ontology)
- Gastro-esophageal reflux
- Exact Synonym (Disease Ontology)
- Gastroesophageal reflux
- Exact Synonym (Disease Ontology)
- GERD
- Exact Synonym (Disease Ontology)
- GERD - Gastro-esophageal reflux disease