lipodystrophy
Information
- Disease name
- lipodystrophy
- Disease ID
- DOID:811
- Description
- "A connective tissue disease that is characterized by marked reduction, absence, and/or the redistribution of adipose tissue." [url:https\://www.ncbi.nlm.nih.gov/pubmed/25690482, url:https\://www.ncbi.nlm.nih.gov/pubmed/25833179]
Disease area statistics
Chromosome band
| Gene symbol | Chromosome | Start | Stop | The number of variant |
|---|---|---|---|---|
| LMNA | 1 | 156,114,711 | 156,140,081 | 4 |
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT02262806 | Active, not recruiting | Phase 2 | Compassionate Use of Metreleptin in Previously Treated People With Partial Lipodystrophy | October 14, 2014 | July 31, 2025 |
| NCT00004329 | Completed | Study of Alpha-2 Adrenergic Receptor Dysfunction in Regional Lipoatrophy | November 1999 | ||
| NCT00005764 | Completed | Phase 4 | A Study of Increased Lactic Acid and Abnormal Fat Distribution in HIV-Positive Patients | May 2000 | |
| NCT00005905 | Completed | Phase 2 | Leptin to Treat Lipodystrophy | June 2000 | April 2003 |
| NCT00006064 | Completed | The Effect of Anti-HIV Treatment on Body Characteristics of HIV-Infected Children | June 2000 | February 2005 | |
| NCT00006185 | Completed | Phase 1 | Underlying Abnormalities in Fat and Muscle Leading to Lipodystrophy Syndrome | September 1999 | August 2003 |
| NCT00006190 | Completed | Phase 4 | A Study to Determine How and Why HIV-Infected Subjects on Anti-viral Treatment Develop Lipodystrophy | November 2000 | November 2001 |
| NCT00006290 | Completed | Perceived Changes in Body Build and Image in Patients Who Are Now Taking or Recently Have Stopped Taking Anti-HIV Drugs | |||
| NCT00006412 | Completed | Phase 3 | Safety and Effectiveness of Fenofibrate and Pravastatin in HIV-Positive Patients With Abnormal Blood Lipids | May 2003 | |
| NCT00015691 | Completed | N/A | Metformin and Rosiglitazone, Alone or in Combination, in HIV-Infected Patients With Insulin and Fat Abnormalities | ||
| NCT00017758 | Completed | Phase 1 | The Effect of Efavirenz and Nelfinavir on the Blood Levels of Certain Lipid-Lowering Drugs | ||
| NCT00021463 | Completed | Phase 2 | Changing to Nonprotease Inhibitor Treatment to Improve Side Effects | ||
| NCT00025883 | Completed | Phase 2 | Leptin to Treat Lipodystrophy | October 2001 | February 2015 |
| NCT00028314 | Completed | N/A | Effects of Treatment Changes on Fat Wasting in the Arms and Legs of HIV Patients | March 2002 | March 2005 |
| NCT00069004 | Completed | A Study of Physical and Metabolic Abnormalities in HIV Infected and Uninfected Children and Youth | October 2003 | August 2005 | |
| NCT00082628 | Completed | Phase 3 | Treatment of Abnormal Adipose Tissue Accumulation in Human Immunodeficiency Virus (HIV) Patients | May 28, 2004 | September 28, 2005 |
| NCT00119379 | Completed | Phase 2 | Effectiveness of Nucleoside Supplementation or Switch to Tenofovir in Reversing Fat Loss in HIV Infected Adults | April 2005 | October 2008 |
| NCT00119405 | Completed | Observational Study of Fat Loss in HIV Infected Adults Taking Nucleoside Reverse Transcriptase Inhibitors (NRTIs) | April 2005 | November 2010 | |
| NCT00001142 | Completed | Metabolism and Body Shape of Healthy Children and Children With Chronic Infections | October 1999 | December 2000 | |
| NCT00123253 | Completed | Phase 3 | TH9507 in Patients With HIV-Associated Lipodystrophy | June 2005 | April 2007 |
| NCT00192621 | Completed | Phase 4 | Seronegatives and Metabolic Abnormalities Protocol 2 (SAMA002): Study to Compare the Effect of Kaletra and Combivir® in HIV-Negative Healthy Subjects | November 2004 | December 2006 |
| NCT00202228 | Completed | Phase 4 | Lactate Metabolism Study in HIV Infected Persons | July 2002 | September 2011 |
| NCT00202241 | Completed | N/A | The Effects of Anabolic Steroids and Protease Inhibitors on People Living With HIV/AIDS | September 1999 | June 2001 |
| NCT00227500 | Completed | Phase 4 | Pravastatin for Hyperlipidaemia in HIV. | July 2001 | October 2004 |
| NCT00119769 | Completed | Phase 4 | The Effect of Low-Dose Human Growth Hormone Therapy in HIV Infected Patients | February 2005 | July 2008 |
| NCT00656175 | Completed | Phase 2 | Raltegravir Therapy for Women With HIV and Fat Accumulation | September 2008 | December 2011 |
| NCT00677313 | Completed | N/A | An Open-Label Treatment Protocol to Provide Metreleptin for the Treatment of Diabetes Mellitus and/or Hypertriglyceridemia Associated With Lipodystrophy | March 2009 | January 2015 |
| NCT00822042 | Completed | Corticosteroid-induced Lipodystrophy and Adipokines | August 2006 | November 2008 | |
| NCT00865007 | Completed | Phase 4 | Lopinavir/r Monotherapy Versus Abacavir/Lamivudine and Lopinavir/r for Limb Fat Recovery in Persons With Lipoatrophy | December 2008 | September 2012 |
| NCT01612858 | Completed | Phase 4 | Metabolic Abnormalities in HIV-infected Persons | June 2011 | November 2014 |
| NCT01679197 | Completed | Phase 2 | Clinical Protocol to Investigate the Efficacy of Recombinant Human Leptin (Metreleptin) in Nonalcoholic Steatohepatitis (NASH) or Nonalcoholic Fatty Liver Disease (NAFLD) Associated With Lipodystrophy | October 8, 2012 | July 13, 2016 |
| NCT01778556 | Completed | Phase 2 | Short-term Effects of Leptin in People With Lipodystrophy | January 26, 2013 | February 23, 2018 |
| NCT01784289 | Completed | Adipocyte, Insulin-resistance and Immunity : Evaluation of Interleukin-7 in Lipodystrophy, Diabetes and Obesity | June 2010 | June 2015 | |
| NCT02056912 | Completed | N/A | Identification of a New Gene Involved in Hereditary Lipodystrophy | January 2014 | January 2014 |
| NCT02258685 | Completed | Factors Mediating Gut Microbiota Dysbiosis and Metabolic Disease in HIV Patients. | November 2014 | July 2019 | |
| NCT02577952 | Completed | Lipodystrophy Connect Patient Registry | January 2014 | November 8, 2018 | |
| NCT02614027 | Completed | Prevalence of Lipodystrophy Syndrome and Its Role as Cause of Metabolic Disturbances | February 2016 | June 2018 | |
| NCT02639286 | Completed | Phase 2 | Efficacy, Safety and Tolerability of ISIS 304801 in People With Partial Lipodystrophy With an Open-Label Extension | December 23, 2015 | September 26, 2019 |
| NCT02647853 | Completed | Phase 1 | Phase 1 Study to Assess the Safety and Tolerability of TAT4 Gel in Healthy Volunteers | October 2014 | December 2014 |
| NCT03275259 | Completed | N/A | Shock Waves for Treatment of Gynoid Lipodystrophy and Localized Fat | April 3, 2017 | December 1, 2018 |
| NCT03407313 | Completed | N/A | CONFORM: Rotational Fractional Resection for Submental Contouring | January 8, 2018 | April 23, 2019 |
| NCT03445351 | Completed | N/A | Quality of Life, Sleep, and Biomarkers in People With HIV/AIDS | January 20, 2013 | September 13, 2016 |
| NCT03826160 | Completed | Growth Hormone Dynamics and Cardiac Steatosis in HIV | January 30, 2019 | April 19, 2022 | |
| NCT03966924 | Completed | N/A | The PREFORM Study: Rotational Fractional Resection for Submental Contouring | March 20, 2019 | October 16, 2019 |
| NCT04578379 | Completed | Insulin Regulated Amino Peptidase in Patients With Familial Lipodystrophy of DUNNIGAN | March 1, 2019 | July 1, 2020 | |
| NCT05239156 | Completed | N/A | Evaluating the Performance and Safety of the Medical Device Janesse in the Treatment of Facial Dermal Tissue Defects | March 14, 2022 | September 13, 2022 |
| NCT05239351 | Completed | N/A | Evaluating Performance and Safety of the Medical Device Jalucomplex in the Treatment of Facial and Neck Tissue Defects | March 7, 2022 | July 7, 2022 |
| NCT05402982 | Completed | N/A | Intraoperative Fluid Management of Liposuction , Cardiometry Versus Rohrich Formula | June 25, 2022 | July 1, 2023 |
| NCT05424913 | Completed | N/A | Exploratory Study of the Relationships Between the Biomarkers of Inflammation, Lipidome and Insulin Resistance and Disorders of Glycemic Regulation in a Cohort of Insulin-resistant Subjects Due to Excess Weight or Dunnigan's Lipodystrophy | August 17, 2021 | August 16, 2023 |
| NCT00461552 | Completed | Phase 2 | Therapeutic Approaches to HAART-Induced Lipodystrophy | January 2003 | September 2014 |
| NCT00608023 | Completed | Phase 3 | TH9507 Extension Study in Patients With HIV-Associated Lipodystrophy | August 2007 | October 2008 |
| NCT00639457 | Completed | N/A | Exercise and Pioglitazone for HIV-Metabolic Syndromes | January 2005 | December 2009 |
| NCT00647946 | Completed | Phase 2 | Study to Evaluate Changes in Limb Fat When Switching From a Thymidine Analogue | February 2003 | February 2006 |
| NCT06089759 | Recruiting | Performance and Safety of the Lipo-transfer Cannulas in Patients Underlying Lipofilling Treatment | August 30, 2023 | April 4, 2024 | |
| NCT05996536 | Recruiting | Feasibility of Adipose Tissue Triglyceride (TG) Labelling in Familial Partial Lipodystrophy (FPLD) | January 3, 2024 | June 1, 2026 | |
| NCT03059121 | Recruiting | The Cleveland Cardiometabolic Cohort | September 2016 | December 2024 | |
| NCT05419037 | Recruiting | Natural History of Pregnancy and Pregnancy Outcomes in Metreleptin-Treated vs Untreated Subjects With Lipodystrophy | September 7, 2022 | March 1, 2025 | |
| NCT06236932 | Recruiting | N/A | Susceptibility to Infectious Diseases in obEsity: an endocRine trAnslational socioLogic Evaluation, "SIDERALE" | December 29, 2023 | May 29, 2025 |
| NCT03900286 | Recruiting | N/A | Low Energy Diet and Familial Partial Lipodystrophy | January 16, 2020 | May 2025 |
| NCT05789251 | Recruiting | N/A | Assess the Possibility of Diagnosing Diabetes and Rediabetes Following Oral Induced Hyperglycemia in Patients With Dunnigan's Partial Familial Lipodystrophy by Replacing 75 g of Glucose With a Standardized Carbohydrate Breakfast and Continuous Interstitial Monitoring Glucose) | June 19, 2023 | June 30, 2025 |
| NCT02262832 | Recruiting | Phase 3 | Compassionate Use of Metreleptin in Previously Treated People With Generalized Lipodystrophy | October 9, 2014 | July 31, 2025 |
| NCT05930106 | Recruiting | N/A | Carotid Doppler Peak Velocity Variation in Liposuction Fluid Management | November 20, 2023 | December 2024 |
| NCT06107439 | Recruiting | N/A | Impact of Lipodystrophy on the Inflammatory State of Non-diabetic Dunnigan Reunion Island Subjects | August 14, 2023 | August 13, 2025 |
| NCT02492997 | Terminated | N/A | Clinical Evaluation of Venus Versa Octipolar Applicator for Reduction of Abdomen Circumference | May 14, 2015 | October 31, 2016 |
| NCT00910936 | Unknown status | Phase 2/Phase 3 | Exercise for Patients With HIV Infections | May 2009 | February 2010 |
| NCT00426296 | Unknown status | Phase 4 | SHARE: Simple HAART With Abacavir, Reyataz, and Epivir | August 2006 | |
| NCT02494752 | Unknown status | N/A | Role of Mesenchymal Stem Cells in Fat Grafting | August 2015 | February 2016 |
| NCT04860063 | Unknown status | Phase 3 | Effect of Berberine on Metabolic Syndrome, Efficacy and Safety in Combination With Antiretroviral Therapy in PLWH. | April 2021 | July 2022 |
| NCT05239117 | Unknown status | N/A | Evaluating the Performance and Safety of the Medical Device Plenhyage® in the Treatment of Dermal Tissue Defects | March 30, 2022 | December 30, 2022 |
| NCT05239130 | Unknown status | N/A | Evaluating the Performance and Safety of the Medical Device Auralya® in the Treatment of Facial Dermal Tissue Defects | March 21, 2022 | December 11, 2022 |
| NCT00715546 | Unknown status | Phase 1 | Autologous Adipose-Derived Stem Cell Transplantation in Patients With Lipodystrophy | October 2007 | November 2011 |
| NCT00331448 | Unknown status | Observational Study of Changes in Fat Distribution and Blood Metabolites in HIV Infected Adults | June 2000 | July 2007 | |
| NCT01093950 | Unknown status | White Light Scanning to Aid Body Contouring: A Pilot Project | January 2005 | October 2020 | |
| NCT04656054 | Unknown status | Hemoglobin Level, Coagulopathy Profile and Electrolyte Balance | November 1, 2020 | October 31, 2022 | |
| NCT00172315 | Unknown status | Proton Magnetic Resonance Spectroscopy (1H MRS) in Evaluating the Bone Marrow, Muscle and Adipose Tissue on Normal and Human Immunodeficiency Virus Infected Subjects | December 2003 | ||
| NCT01788462 | Withdrawn | Egrifta Replacement and Sleep Disordered Breathing | May 2012 | ||
| NCT00360139 | Withdrawn | Phase 4 | Clinical Trial to Determine the Efficacy of Sculptra™ Dermal Filler for the Correction of Contour Deformities Caused by Lipoatrophy | December 2008 |
- Disase is a (Disease Ontology)
- DOID:65
- Cross Reference ID (Disease Ontology)
- ICD10CM:E88.1
- Cross Reference ID (Disease Ontology)
- ICD9CM:272.6
- Cross Reference ID (Disease Ontology)
- MESH:D008060
- Cross Reference ID (Disease Ontology)
- NCI:C97093
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:190789006
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0023787
- HPO Human Phenotype ID (Human Phenotype Ontology)
- HP:0009125
- MeSH unique ID (MeSH (Medical Subject Headings))
- D008060