nephrotic syndrome
Information
- Disease name
- nephrotic syndrome
- Disease ID
- DOID:1184
- Description
- "A nephrosis characterized by marked increase in glomerular protein permeability resulting in marked elevation of urine protein levels, hypoalbuminemia, hyperlipidemia, and hypercoagulability." [url:https\://en.wikipedia.org/wiki/Nephrotic_syndrome, url:https\://www.niddk.nih.gov/health-information/kidney-disease/nephrotic-syndrome-adults]
Disease area statistics
Chromosome band
| Gene symbol | Chromosome | Start | Stop | The number of variant |
|---|---|---|---|---|
| NPHS1 | 19 | 35,825,372 | 35,852,504 | 88 |
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT02194582 | Active, not recruiting | Genetic Causes of FSGS, Nephrotic Syndrome, or Kidney Failure | June 1996 | January 2035 | |
| NCT04311684 | Active, not recruiting | Non-invasive Assessment of Mechano-chemical Properties of Urine Proteins by Hybrid Brillouin-Raman Spectroscopy | April 6, 2020 | December 2023 | |
| NCT03949855 | Active, not recruiting | Phase 2 | Belimumab With Rituximab for Primary Membranous Nephropathy | March 6, 2020 | March 1, 2030 |
| NCT03210688 | Active, not recruiting | Phase 4 | Active Vitamin D And Reduced Dose Prednisolone for Treatment in Minimal Change Nephropathy | May 1, 2018 | May 31, 2025 |
| NCT00004990 | Completed | Phase 2 | Once-A-Month Steroid Treatment for Patients With Focal Segmental Glomerulosclerosis | March 2000 | December 2004 |
| NCT00035334 | Completed | Phase 2/Phase 3 | Study of the Safety and Efficacy of NC-503 in Secondary (AA) Amyloidosis | October 2001 | December 2004 |
| NCT00172276 | Completed | Angiotensin Converting Enzyme Gene Polymorphism in Children With Idiopathic Nephrotic Syndrome | |||
| NCT00286910 | Completed | Urinary Aquaporin 2 and Expression of the NPHS2 Gene in Adults Suffering From Nephrotic Syndrome | May 2005 | ||
| NCT00289328 | Completed | Glucocorticoid-induced Osteopenia in Children | November 2001 | April 2006 | |
| NCT06026787 | Completed | Phase 4 | Clinical Value of Adding Dapagliflozin in Patients With Nephrotic Syndrome | August 1, 2022 | August 1, 2023 |
| NCT00354731 | Completed | Phase 3 | Efficacy of Pentoxifylline on Primary Nephrotic Syndrome | August 2006 | April 2011 |
| NCT00362531 | Completed | Phase 2/Phase 3 | Tacrolimus Combined With Prednisone Treatment of Idiopathic Membranous Nephropathy and Nephrotic Syndrome | November 2004 | January 2007 |
| NCT00615667 | Completed | Phase 3 | Prospective, Multicenter Study of the Efficacy and Tolerance of Tacrolimus on Refractory Nephrotic Syndrome (RNS) | June 2006 | September 2008 |
| NCT00690586 | Completed | Fluid Balance, Hormones and Urine Proteomics in Nephrotic Syndrome in Childhood | December 2007 | May 2010 | |
| NCT05912673 | Completed | Renal Doppler in Pediatric Patients With Idiopathic Nephrotic Syndrome | January 28, 2023 | August 30, 2023 | |
| NCT04818723 | Completed | N/A | Role of Montelukast in Preventing Relapse in Childhood Idiopathic Nephrotic Syndrome | February 1, 2019 | May 30, 2020 |
| NCT00981838 | Completed | Phase 3 | Rituximab in Multirelapsing Minimal Change Disease (MCD) or Focal Segmental Glomerulosclerosis (FSGS) | April 2009 | April 2011 |
| NCT00983034 | Completed | N/A | The Effects of Helicobacter Pylori Eradication on Proteinuria in Patients With Membranous Nephropathy | March 2006 | July 2009 |
| NCT01028287 | Completed | Phase 4 | Adrenocorticotropic Hormone (ACTH) Treatment of Nephrotic Range Proteinuria in Diabetic Nephropathy (NRDN) | May 2009 | July 2011 |
| NCT01162005 | Completed | Phase 4 | Therapeutic Effect of Tacrolimus on Primary Nephrotic Syndrome in Children | July 2010 | October 2013 |
| NCT01197040 | Completed | Phase 3 | Evaluation of Low Dose Corticosteroids Efficiency, Associated With Myfortic ® in the Treatment of Nephrotic Syndrome | October 2009 | June 2015 |
| NCT01252901 | Completed | Registry for Patients With Wilms' Tumor Suppressor Gene 1 (WT1) Mutation Associated Diseases | October 2010 | June 2014 | |
| NCT01309477 | Completed | Phase 3 | The Efficacy and Tolerance of Tacrolimus Sustained-release Capsules on Refractory Nephrotic Syndrome (RNS) | January 2011 | October 2011 |
| NCT01386957 | Completed | Steroid Treatment of Idiopathic Nephrotic Syndrome | July 2011 | December 2017 | |
| NCT01411982 | Completed | Role of PACAP in Nehprotic Syndrome | September 2011 | September 2014 | |
| NCT01447485 | Completed | Phase 1 | Pharmacokinetics Following Single-dose of Valsartan in Japanese Pediatric Patients | August 2011 | October 2011 |
| NCT01616446 | Completed | Pharmacokinetics of Cyclosporin in Nephrotic Syndrome | February 2007 | February 2010 | |
| NCT01663129 | Completed | Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study | January 2005 | March 6, 2014 | |
| NCT01845428 | Completed | Phase 1 | Lipid Lowering Agents to Limit Lipid Oxidation and Activation of Clotting System in Nephrotic Syndrome | May 2012 | January 2017 |
| NCT01895894 | Completed | Phase 4 | Mycophenolate Mofetil in Pediatric Steroid Dependent Nephrotic Syndrome | September 2013 | December 2016 |
| NCT02132195 | Completed | Phase 3 | Adrenocorticotropic Hormone (ACTH) for Frequently Relapsing and Steroid Dependent Nephrotic Syndrome | May 2014 | March 2018 |
| NCT02190955 | Completed | Assessment of the Educational Experiences for Patients Newly Diagnosed With Nephrotic Syndrome | January 2013 | May 2014 | |
| NCT02238418 | Completed | Phase 4 | Efficacy of Usual Vitamin D Supplementation and Its Impact on Children and Adolescents Calciuria. | September 2014 | October 2017 |
| NCT02257697 | Completed | Phase 3 | A Study to Evaluate the Efficacy and Safety of Mizoribine in the Treatment of Refractory Nephrotic Syndrome | November 2014 | November 2018 |
| NCT04278729 | Completed | Phase 1 | A Prospective Multi-dose Study of Apixaban in Subjects With Nephrotic Syndrome | April 14, 2021 | September 22, 2023 |
| NCT02394119 | Completed | Phase 2 | Ofatumumab Versus Rituximab in Children With Steroid and Calcineurin Inhibitor Dependent Idiopathic Nephrotic Syndrome | June 2015 | May 2019 |
| NCT02427880 | Completed | Phase 4 | Role of Acetazolamide and Hydrochlorothiazide Followed by Furosemide in Treating Nephrotic Edema | April 2015 | June 2015 |
| NCT02438982 | Completed | Phase 3 | Efficacy and Safety of Rituximab to That of Calcineurin Inhibitors in Children With Steroid Dependent Nephrotic Syndrome | May 8, 2015 | September 2016 |
| NCT03141970 | Completed | Phase 3 | Prednisolone Trial in Children Younger Than 4 Years | July 1, 2015 | October 31, 2021 |
| NCT02592798 | Completed | Phase 2 | Pilot Study to Evaluate the Safety and Efficacy of Abatacept in Adults and Children 6 Years and Older With Excessive Loss of Protein in the Urine Due to Either Focal Segmental Glomerulosclerosis (FSGS) or Minimal Change Disease (MCD) | March 9, 2016 | January 28, 2020 |
| NCT02599532 | Completed | Phase 1 | Pharmacokinetics of Apixaban in Nephrotic Syndrome | April 30, 2017 | June 28, 2019 |
| NCT03387176 | Completed | Efficacy of a Gluten-free Diet in Difficult to Manage Nephrotic Syndrome: Utility of Plasma Zonulin Levels as a Predictive Biomarker | December 1, 2017 | June 14, 2021 | |
| NCT03347357 | Completed | Phase 4 | Pharmacokinetics of Tacrolimus in Children | January 1, 2012 | September 30, 2017 |
| NCT03332420 | Completed | The Efficacy of Huaiqihuang Granule in Children With Primary Nephrotic Syndrome | November 16, 2017 | August 31, 2021 | |
| NCT02455908 | Completed | Phase 1/Phase 2 | IL-2 for Multi Drug Resistant Nephrotic Syndrome | February 2012 | August 2012 |
| NCT00001959 | Completed | Phase 2 | Pirfenidone to Treat Kidney Disease (Focal Segmental Glomerulosclerosis) | December 1999 | October 2008 |
| NCT00001212 | Completed | Phase 2 | Drug Therapy in Lupus Nephropathy | November 1986 | September 2004 |
| NCT06071533 | Completed | Effectiveness and Safety of Danshen Injection for Acute Kidney Injury in Primary Nephrotic Syndrome | January 1, 2012 | October 3, 2023 | |
| NCT06443034 | Not yet recruiting | Predictive Determinants of Nephrotic Syndrome Remission in Patients With At-risk Polymorphism of APOL1 | June 30, 2024 | December 30, 2024 | |
| NCT05904197 | Not yet recruiting | N/A | Effectiveness of Educational Gamified Cards About Nephrotic Syndrome | November 1, 2023 | June 30, 2024 |
| NCT05966818 | Not yet recruiting | Phase 4 | Effect of Dapagliflozin in Non-Diabetic Patients With Nephrotic Syndrome. | August 1, 2023 | March 1, 2024 |
| NCT06315504 | Not yet recruiting | Circulating Factors in Nephrotic Syndrome | April 1, 2024 | April 1, 2034 | |
| NCT06334692 | Not yet recruiting | Autoantibodies Against-nephrin in Idiopathic Nephrotic Syndrome | May 2024 | May 2028 | |
| NCT05623033 | Recruiting | The Predictive Value of Dynamic Changes of CD4+T Lymphocytes in Primary Nephrotic Syndrome With Infection | November 16, 2022 | December 31, 2025 | |
| NCT05704400 | Recruiting | Phase 2 | Efficacy of Anti-CD20 Ab Associated With Anti-CD38 in the Childhood Multidrug Dependent and Resistant Nephrotic Syndrome | March 1, 2023 | March 1, 2025 |
| NCT05712369 | Recruiting | N/A | B Cells in Idiopathic Nephrotic Syndrome | April 2, 2019 | December 2025 |
| NCT05716880 | Recruiting | Phase 3 | Ketoanalogues for Muscle Mass Loss in Nephrotic Syndrome | January 3, 2023 | August 31, 2027 |
| NCT06325137 | Recruiting | Transcriptome Analysis in Idiopathic Nephrotic Syndrome: Steroid Responsiveness | March 16, 2023 | March 2025 | |
| NCT00001979 | Recruiting | Immune System Related Kidney Disease | June 25, 1992 | ||
| NCT06325098 | Recruiting | N/A | Implementation of a Diagnostic Workflow for Personalized Diagnosis of Nephrotic Syndrome | January 26, 2022 | June 30, 2026 |
| NCT05696977 | Recruiting | Phase 4 | Effect of Obesity on Cyclosporine Blood Trough Level in Nephrotic Syndrome Patients | April 17, 2022 | April 2024 |
| NCT03750136 | Recruiting | N/A | Furosemide Alone or Unexpectedly With Solution of Hypertonic Saline in Nephrotic Syndrome | December 15, 2018 | March 1, 2023 |
| NCT01605266 | Recruiting | INSIGHT (Insight Into Nephrotic Syndrome) | January 2011 | January 2032 | |
| NCT06161701 | Recruiting | Steroid Diabetes in Patients With Kidney Disease | January 10, 2024 | February 28, 2027 | |
| NCT04759274 | Recruiting | N/A | Diuretic Tuner Clinical Decision Support | November 20, 2023 | August 2024 |
| NCT00977977 | Recruiting | Phase 2 | Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy | December 22, 2010 | January 31, 2025 |
| NCT06162546 | Recruiting | ARREST-NEPHROSIS - Austrian Resistant Nephrotic Syndrome Treatment Response Registry and Biobank | January 1, 2023 | December 31, 2033 | |
| NCT06373913 | Recruiting | The Role of Proprotein-convertase-subtilisin/Kexin-type 9 in Kidney Damage in Nephrotic Syndrom | June 1, 2023 | July 30, 2028 | |
| NCT03501459 | Recruiting | Phase 3 | Lymphocyte Markers As Predictors Of Responsiveness To Rituximab Among Patients With Idiopathic Nephrotic Syndrome | June 2008 | December 2025 |
| NCT04174066 | Recruiting | From Immune System Damage to Podocyte Cell Damage: Prospective Database and Biological Collection of Patients (Children and Adults) With MGLS and HSFP | May 20, 2020 | May 20, 2025 | |
| NCT05505500 | Recruiting | Interview Study of Adult and Child Patients and Parents of Children With Swelling Due to Nephrotic Syndrome. | April 18, 2022 | April 2026 | |
| NCT03001934 | Recruiting | Super Chinese Nephrotic Syndrome Registration System (SUCCESS) | April 2016 | December 2028 | |
| NCT03042637 | Suspended | Safety and Efficacy of Combination Acthar Gel and Tacrolimus in the Treatment of Steroid Resistant Nephrotic Syndrome | January 2012 | December 2021 | |
| NCT00883636 | Terminated | Cardiomyopathy in Steroid-resistant Nephrotic Syndrome: Impact of Focal Segmental Glomerulosclerosis | October 2008 | October 2011 | |
| NCT00004466 | Terminated | Phase 2 | Pilot Study of Atorvastatin in Children With Chronic Hyperlipidemia Secondary to Nephrotic Syndrome | October 1998 | December 1999 |
| NCT03004001 | Terminated | Phase 2 | Effect of PCSK9-Antibody (Alirocumab) on Dyslipidemia Secondary to Nephrotic Syndrome | January 2017 | December 2019 |
| NCT04558892 | Terminated | Phase 2/Phase 3 | Anti-Xa Activity of Enoxaparin for Prevention of Venous Thromboembolism in Severe Nephrotic Syndrome. | October 1, 2015 | November 30, 2018 |
| NCT02394106 | Terminated | Phase 2 | Ofatumumab in Children With Drug Resistant Idiopathic Nephrotic Syndrome | July 2015 | June 2019 |
| NCT05079789 | Terminated | Phase 3 | Amiloride in Nephrotic Syndrome | June 8, 2020 | November 20, 2022 |
| NCT02966717 | Unknown status | Phase 2 | Rituximab Combined With MSCs in the Treatment of PNS (3-4 Stage of CKD) | August 2016 | October 2021 |
| NCT02602873 | Unknown status | Study of Tacrolimus Used for Pediatric Patients With Nephrotic Syndrome Based on Pharmacogenomics and Metabonomics | August 2015 | August 2020 | |
| NCT03592030 | Unknown status | Diagnostic and Prognostic Value of Miss-1 Study in Children and Adult With Nephrotic Syndrome MISSNEPHROTIQUE | January 2016 | December 2018 | |
| NCT04045171 | Unknown status | Population Pharmacokinetics of Tacrolimus in Nephrotic Syndrome | August 10, 2019 | December 31, 2020 | |
| NCT02382575 | Unknown status | Phase 4 | Efficacy and Safety of Rituximab to That of Calcineurin Inhibitors in Children With Steroid Resistant Nephrotic Syndrome | March 15, 2015 | December 2023 |
| NCT04850378 | Unknown status | Phase 1/Phase 2 | Causes and Prevention of Thromboembolic Disease in Nephrotic Syndrome | March 25, 2021 | October 1, 2023 |
| NCT05301829 | Unknown status | Thrombin Generation Assay to Assess Thrombotic Risk in Nephrotic Patients | April 1, 2022 | March 31, 2024 | |
| NCT05392244 | Unknown status | Characteristics of Peripheral Blood Lymphocyte Subsets in Children With PNS | May 30, 2022 | August 31, 2022 | |
| NCT00308321 | Unknown status | Phase 4 | Long Term Tapering or Standard Steroids for Nephrotic Syndrome | September 2003 | October 2008 |
| NCT03326037 | Unknown status | Study of The Association of Mutations in The NPHS2 Gene and Nephrotic Syndrome in Children and Adults in Middle East | October 2016 | June 2020 | |
| NCT05599815 | Withdrawn | Phase 2 | Part 1 - A Clinical Trial in Patients With Frequently Relapsing and Steroid-Dependent Nephrotic Syndrome | January 2023 | May 2023 |
- Disase is a (Disease Ontology)
- DOID:2527
- Cross Reference ID (Disease Ontology)
- ICD10CM:N04
- Cross Reference ID (Disease Ontology)
- ICD9CM:581
- Cross Reference ID (Disease Ontology)
- MESH:D009404
- Cross Reference ID (Disease Ontology)
- NCI:C34845
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:155851004
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0027726
- HPO alt_id (Human Phenotype Ontology)
- HP:0000801
- HPO alt_id (Human Phenotype Ontology)
- HP:0004718
- HPO alt_id (Human Phenotype Ontology)
- HP:0008638
- HPO alt_id (Human Phenotype Ontology)
- HP:0008727
- HPO Human Phenotype ID (Human Phenotype Ontology)
- HP:0000100
- OMIM Phenotype Series Number (OMIM)
- PS256300
- ICD10 preferred id (Insert disease from ICD10)
- D0011203
- ICD10 class code (Insert disease from ICD10)
- N04
- MeSH unique ID (MeSH (Medical Subject Headings))
- D009404