major depressive disorder

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Information
Disease name
major depressive disorder
Disease ID
DOID:1470
Description
"A depressive disorder that is characterized by at least two weeks of loss of interest or pleasure in normally enjoyable activities or depressed mood along with additional cognitive or somatic impairments such as appetite or weight changes, sleep difficulties, psychomotor agitation or retardation, fatigue or loss of energy, diminished ability to think or concentrate, feelings of worthlessness or excessive guilt, and suicidality." [url:http\://en.wikipedia.org/wiki/Major_depressive_disorder, url:https\://pubmed.ncbi.nlm.nih.gov/30333763]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT04358900 Active, not recruiting Unobtrusive Monitoring of Affective Symptoms and Cognition Using Keyboard Dynamics (UnMASCK) September 17, 2020 August 31, 2025
NCT03096886 Active, not recruiting N/A Novel Neural Circuit Biomarkers of Major Depression Response to CCBT June 5, 2017 October 23, 2024
NCT04541563 Active, not recruiting N/A Fisher Wallace Neurostimulation & Depression Study August 24, 2020 November 30, 2021
NCT06126497 Active, not recruiting Phase 2 Study Evaluating Safety and Efficacy of Ropanicant in MDD Patients February 5, 2024 August 2024
NCT05205915 Active, not recruiting N/A Home-based Transcranial Direct Current Stimulation (tDCS) for Major Depressive Disorders (MDD) February 2, 2022 December 2022
NCT02506127 Active, not recruiting N/A Intermittent Theta Burst Stimulation for MDD December 9, 2017 December 8, 2023
NCT04846829 Active, not recruiting Early Phase 1 Effects of Intravenous (IV) Citalopram Hydrochloride During Transcranial Magnetic Stimulation in Major Depressive Disorder (MDD) April 24, 2017 April 24, 2026
NCT05996900 Active, not recruiting N/A Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans September 1, 2023 July 1, 2028
NCT02046330 Active, not recruiting N/A Deep Brain Stimulation (DBS) Therapy for Treatment Resistant Depression November 2013 April 2027
NCT00367003 Active, not recruiting N/A Deep Brain Stimulation for Treatment Resistant Depression September 2006 January 2029
NCT06332261 Active, not recruiting Standardized Assessment in Depression Treatment in Routine Psychiatric Services March 8, 2024 April 2024
NCT04780542 Active, not recruiting N/A Internet-delivered Cognitive Behavioral Treatment of Depression and Anxiety in Latin American College Students March 1, 2021 June 2025
NCT03287362 Active, not recruiting N/A Effects of Schema Therapy vs. Cognitive Behavioral Therapy vs. Individual Supportive Therapy September 13, 2017 December 2024
NCT04278521 Active, not recruiting N/A Mechanism of Action of Transcranial Magnetic Stimulation November 2011 April 1, 2025
NCT03615794 Active, not recruiting A Study of Pregnant and Postpartum Women With and Without Mood Disorders October 1, 2017 October 2024
NCT02959502 Active, not recruiting N/A Home-Based CR and tDCS to Enhance Cognition in Persons With Mild Cognitive Impairment and Late Life Depression October 31, 2016 December 2024
NCT05531591 Active, not recruiting Phase 4 RCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT) August 1, 2019 February 28, 2025
NCT04410341 Active, not recruiting Phase 1/Phase 2 The DPP-4 Inhibitor Vildagliptin as Adjunct in Major Depressive Disorder Patients May 1, 2020 December 1, 2024
NCT04990687 Active, not recruiting N/A Vagal Nerve Stimulation for Treatment Resistant Major Depression January 1, 2022 April 1, 2024
NCT05697172 Active, not recruiting N/A Low Intensity Ultrasound Neuromodulation of Repetitive Negative Thinking In Depression December 15, 2022 March 30, 2024
NCT06028984 Active, not recruiting N/A Self-guided Treatment for Depression October 12, 2023 September 2025
NCT04711915 Active, not recruiting Phase 1 Fixed Order, Open-Label, Dose-Escalation Study of DMT in Humans March 17, 2021 December 1, 2024
NCT03554174 Active, not recruiting Phase 1 Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive Disorder February 27, 2018 April 2025
NCT05988619 Active, not recruiting N/A iCBT With TMS in Patients With MDD March 21, 2021 June 30, 2024
NCT05426265 Active, not recruiting N/A The Effects of Videogames on Depression Symptoms and Brain Dynamics June 28, 2022 December 31, 2024
NCT04977856 Active, not recruiting N/A Efficacy and Cost-effectiveness of Internet-delivered CBT for Adolescents With Depression September 10, 2021 July 31, 2025
NCT04106466 Active, not recruiting N/A DBS for TRD With the Medtronic Summit RC+S January 21, 2020 December 31, 2030
NCT05061706 Active, not recruiting Phase 3 Multicenter Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder September 30, 2021 May 2024
NCT03481049 Active, not recruiting N/A Individualizing Incentives for Alcohol in the Severely Mentally Ill May 5, 2018 August 31, 2024
NCT03573349 Active, not recruiting Early Phase 1 Ketamine Associated ACC GABA and Glutamate Change and Depression Remission: January 3, 2019 December 2026
NCT05439603 Active, not recruiting Phase 2 ANC-501 in the Treatment of Adults With Major Depressive Disorder September 19, 2022 November 25, 2023
NCT05530642 Active, not recruiting N/A An Augmented Training Program for Preventing Post-Traumatic Stress Injuries Among Diverse Public Safety Personnel September 22, 2020 December 31, 2024
NCT04337242 Active, not recruiting N/A Blended Care Versus Face-to-Face Therapy for Depression March 29, 2019 September 30, 2026
NCT03674138 Active, not recruiting N/A Pharmacogenomic-Guided Antidepressant Drug Prescribing in Cancer Patients September 12, 2018 October 2, 2024
NCT05249309 Active, not recruiting Naturalistic Study of Ketamine in the Treatment of Depression May 1, 2021 December 15, 2023
NCT03322774 Active, not recruiting N/A Sleep To Reduce Incident Depression Effectively March 9, 2018 March 9, 2024
NCT05144880 Active, not recruiting N/A Effects of Electroacupuncture With Different Frequencies for Major Depressive Disorder November 1, 2021 December 30, 2024
NCT04530942 Active, not recruiting N/A The Efficacy and Prediction of Deep Brain Stimulation for Treatment-resistant Depression March 29, 2021 December 30, 2024
NCT03899090 Active, not recruiting N/A Floatation-REST (Reduced Environmental Stimulation Therapy) for Anxiety and Depression April 8, 2019 May 31, 2024
NCT05657691 Active, not recruiting Phase 2 Xanamem® in Adults With Major Depressive Disorder and Impaired Cognition (XanaCIDD) November 28, 2022 July 15, 2024
NCT06009003 Available REL-1017 Expanded Access Treatment
NCT00265291 Completed Phase 2 Antidepressant Treatment of Mexican-Americans: UCLA Pharmacogenetics and Pharmacogenomics Research Group November 1999 October 2008
NCT01492309 Completed N/A Beat the Blues in Pregnancy Study - Transcranial Magnetic Stimulation November 2011 January 2017
NCT03511599 Completed Phase 1 Cycloserine rTMS Plasticity Augmentation in Depression September 3, 2018 April 21, 2021
NCT03735576 Completed N/A Cognitive Behavioural Therapy for the Treatment of Late Life Depression October 1, 2017 May 11, 2021
NCT02544607 Completed Phase 4 Ketamine for Depression: An MRI Study March 2016 December 29, 2017
NCT01924520 Completed Phase 1 Oral Multiple-dose Study in Patients With Major Depressive Disorder November 2010 May 2011
NCT00742573 Completed Phase 2 Incorporating Patient Treatment Choice to Improve Treatment Retention in Depressed Hispanics August 2008 January 10, 2014
NCT01431573 Completed N/A Wake Therapy in the Treatment of Depression July 2011 August 2016
NCT03861988 Completed Phase 4 Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac Surgery August 22, 2019 September 27, 2022
NCT03378570 Completed N/A rTMS for MDD: 5.5cm Rule vs. F3 Targeting May 1, 2018 September 13, 2022
NCT00205933 Completed Behavioral Processes Underlying Reward Processing in Depression April 2004 June 2007
NCT01502033 Completed N/A Study of Repetitive Transcranial Magnetic Stimulation (rTMS) in Depressed Teens December 2011 December 2013
NCT04366258 Completed N/A Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression August 1, 2020 June 24, 2022
NCT03937596 Completed Phase 2 Adjunctive D-Cycloserine in Major Depressive Disorder December 1, 2019 December 24, 2020
NCT05905120 Completed Phase 1 Assessing Dopamine Transporter Occupancy in the Healthy Adult Brain With Toludivenlafaxine Hydrochloride Extended-Release Tablets Using 11C-CFT Positron Emission Tomography (PET) March 2, 2023 July 26, 2023
NCT02366364 Completed Phase 1 Study of Safety, Tolerability and Pharmacokinetics of NRX-1074 in Normal Healthy Volunteers February 2015 April 2015
NCT00326144 Completed Phase 3 Efficacy and Safety of Quetiapine Fumarate Sustained Release (SEROQUEL SR) in the Treatment of Major Depressive Disorders April 2006 May 2007
NCT01976975 Completed Brain Mechanisms of Human Motivation October 2013 January 2018
NCT00977353 Completed Phase 2 N-methylglycine (Sarcosine) Treatment for Depression April 2009 July 2011
NCT00851006 Completed Phase 2 Creatine Treatment for Female Adolescents With Depression Who Are Non-Responders to Fluoxetine or Escitalopram April 2009 December 2012
NCT00320372 Completed Treatment-Resistant Depression Registry January 2006 May 2015
NCT04630964 Completed Phase 2 The Effect of Psilocybin on MDD Symptom Severity and Synaptic Density January 1, 2021 April 18, 2024
NCT01684163 Completed Phase 2 Efficacy and Safety of GLYX-13 in Subjects With Inadequate/Partial Response to Antidepressants November 2012 June 2014
NCT00797966 Completed Phase 2 Study of the Safety and Efficacy of OPC-34712 as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder May 2009 July 2010
NCT00075257 Completed Phase 3 Study Evaluating DVS-233 SR In Adult Outpatients With Major Depressive Disorder August 2005
NCT00905424 Completed Phase 2 Exploratory Study of SPD489 in Adults With Major Depressive Disorder (MDD) as Augmentation Therapy to an Antidepressant July 30, 2009 August 4, 2010
NCT01397903 Completed Description of Treatment Management of Patients With Major Depressive Disorder and Inadequate Response September 2011 March 2012
NCT01922219 Completed N/A Predictors of Treatment Outcome With Cognitive Behavioral Therapy for Depression December 2009 August 2015
NCT01774045 Completed Phase 1 A Dose Escalation Phase I Study of PDC-1421 Capsule Targeting in Depression November 2012 July 2013
NCT02079610 Completed N/A Effect of Amygdala Neurofeedback on Depressive Symptoms and Processing Biases April 2014 April 2016
NCT01409096 Completed Phase 4 Study Using Pregnenolone to Treat Bipolar Depression March 2010 November 2011
NCT01273376 Completed Phase 2 Safety and Efficacy of RX-10100 to Treat Major Depressive Disorder December 2010 October 2011
NCT02156622 Completed CID 0911 - Adaptation of A Depression Treatment Intervention for HIV Patients in Cameroon July 2009 November 2012
NCT00887224 Completed Phase 3 Relapse Prevention Study Of Desvenlafaxine Succinate Sustained Release In Outpatients With Major Depressive Disorder June 2009 March 2011
NCT05837351 Completed N/A The CARE (Collaborative Adolescent Running Experience) Project December 5, 2023 April 30, 2024
NCT02339285 Completed N/A Transcranial Alternating Current Stimulation for Major Depressive Disorder May 7, 2015 June 19, 2017
NCT03957850 Completed N/A Cognitive Reappraisal in Adolescents With Major Depression May 27, 2019 November 22, 2021
NCT04216095 Completed Phase 2/Phase 3 Comparative Effectiveness Clinical Trial of MST Compared to ECT in Major Depressive Disorder June 7, 2013 October 7, 2015
NCT00474708 Completed Phase 4 Study Comparing the Efficacy of Venlafaxine XR Vs. SSRIs and Conventional Antidepressants in Depressed Patients April 2007 March 2008
NCT00166296 Completed Phase 2 Efficacy and Safety of Escitalopram for Prevention of Depression Induced by Peg-Interferon in Hepatitis C Patients March 2005 October 2007
NCT04088448 Completed Phase 1/Phase 2 The Antidiabetic Metformin as a Novel Adjunct to Antidepressants in Major Depressive Disorder Patients January 1, 2017 June 1, 2020
NCT03812588 Completed Phase 4 Contact: Developing New Clinical Management Strategies January 30, 2019 August 1, 2021
NCT00869765 Completed Phase 2 Transcranial Direct Current Stimulation (tDCS) Augmentation by D-Cycloserine as a Treatment for Depression April 2009 September 2010
NCT03538691 Completed Phase 3 A Trial to Evaluate the Efficacy, Safety & Tolerability of Brexpiprazole in the Maintenance Treatment of Adults With Major Depressive Disorder July 13, 2018 July 29, 2022
NCT04325100 Completed N/A Intervention Targeting Motivational Negative Symptoms April 20, 2019 February 27, 2020
NCT02747134 Completed N/A Combining Emotion Regulation and Mindfulness Skills for Preventing Depression Relapse September 2008
NCT00034983 Completed Phase 3 Treatment of Patients With Major Depressive Disorder With MK0869 (0869-066)(COMPLETED) October 29, 2001 December 29, 2003
NCT01326793 Completed N/A Internet-Based Depression Screening for College Students September 2008 December 2014
NCT00063206 Completed Phase 3 Study Evaluating DVS-233 in Adult Outpatients With Major Depressive Disorder May 2004
NCT00388973 Completed Phase 3 Efficacy and Safety Study of Seroquel SR in the Treatment of Major Depressive Disorder September 2006 December 2007
NCT03708159 Completed N/A Maintenance of Response After rTMS for Depression Using tDCS September 24, 2018 August 31, 2020
NCT03072823 Completed N/A Omega-3 Polyunsaturated Fatty Acids on Major Depressive Disorder in Patients With Cardiovascular Diseases January 27, 2016 June 30, 2017
NCT01443715 Completed Phase 2/Phase 3 A Stepped Care Model of Adolescent Depression Treatment in Primary Care September 2011 July 2014
NCT04731454 Completed N/A Feasibility and Acceptability of a Healthy Nordic Diet Intervention in Depressed and Non-depressed Adults September 15, 2020 October 2, 2020
NCT01583569 Completed Complex Dynamic Systems in Mood Disorders November 2011 December 2014
NCT04039022 Completed Phase 3 Open-Label Safety Study of AXS-05 in Subjects With Depression July 8, 2019 October 23, 2020
NCT01496248 Completed N/A Efficacy Study of Korean Red Ginseng to Treat Depression August 2011 December 2012
NCT00351910 Completed Phase 3 Efficacy of Seroquel SR in Combination With an Antidepressant in Treatment of Major Depressive Disorder May 2006 April 2007
NCT03053362 Completed Phase 2/Phase 3 THINC-it Vortioxetine - Sensitivity to Change May 24, 2017 August 8, 2018
NCT04832425 Completed Phase 2/Phase 3 A Clinical Trial of PRAX-114 in Participants With Major Depressive Disorder March 30, 2021 May 5, 2022
NCT01582581 Completed N/A Study of Technology-assisted Treatment of Adolescent Depression March 2012 December 2014
NCT00452595 Completed Phase 3 Study Evaluating DVS-233 for Treatment of Outpatients With Major Depressive Disorder January 2004 May 2005
NCT02805881 Completed N/A Safety and Feasibility of Combined Trigeminal and Occipital Transcutaneous Nerve Stimulation (CTO-TNS) in Major Depressive Disorder (MDD) May 2016 July 2021
NCT02871141 Completed Multimodal Imaging of ECT Effects September 1, 2017 December 31, 2021
NCT03095820 Completed N/A Multidomain Intervention for Older Adults With Major Depressive Disorder March 1, 2016 January 31, 2017
NCT01485887 Completed Phase 3 Venlafaxine ER Long-Term Extension Study for Major Depressive Disorder (MDD) January 2012 January 2014
NCT02372799 Completed Phase 3 Safety and Efficacy of Vilazodone in Pediatric Patients With Major Depressive Disorder (VLZ-MD-22) February 28, 2015 September 11, 2018
NCT04041284 Completed Phase 4 A Study to Evaluate the Efficacy and Safety of Fremanezumab for Preventive Treatment of Migraine in Patients With Major Depressive Disorder September 13, 2019 August 31, 2022
NCT01182103 Completed Epigenetic Regulation of BDNF in Major Depression August 2010 May 2013
NCT04679753 Completed Phase 4 Brainsway DTMS for Treatment of MDD Using iTBS January 1, 2019 July 1, 2020
NCT01435759 Completed Phase 2 SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder May 31, 2011 January 17, 2014
NCT03718013 Completed N/A Efficacy and Safety of Accelerated Transcranial Magnetic Stimulation With H1-coil (dTMS) December 1, 2018 November 1, 2019
NCT02269540 Completed Early Phase 1 A New Treatment Approach for Major Depressive Disorder Based Upon Targeting Monoamine Oxidase A (MAO-A) October 2014 July 2018
NCT05347199 Completed Phase 1 Effects of a Single Dose of Amisulpride on Functional Brain Changes May 17, 2022 September 25, 2023
NCT00095134 Completed Phase 3 Study Comparing Adjunctive Risperidone Versus Placebo in Major Depressive Disorder That Is Not Responding to Standard Therapy October 2004 November 2005
NCT05524519 Completed N/A Intradermal Acupuncture Based on Changes in Biological Specificity of Acupoints for Major Depressive Disorder January 1, 2022 December 31, 2023
NCT04678232 Completed N/A Positive Processes and Transition to Health October 1, 2021 June 30, 2023
NCT04969510 Completed Phase 2 A Clinical Trial of Adjunctive and Monotherapy PRAX-114 in Participants With Major Depressive Disorder June 24, 2021 August 2, 2022
NCT01916824 Completed Phase 4 Effects of Treatment on Decision-making in Major Depression August 2013 December 2015
NCT05633368 Completed Impact of Covid-19 Pandemic on Patients Receiving Continuation or Maintenance Electroconvulsive Therapy March 31, 2020 June 19, 2020
NCT00785434 Completed Phase 4 Efficacy and Safety of Escitalopram Doses up to 50mg in Treatment of MDD October 2008 December 2009
NCT00128479 Completed Phase 3 A United States Study of the Safety and Tolerability of Corlux for Psychotic Symptoms in Psychotic Major Depression September 2004 January 2007
NCT01429831 Completed Phase 4 Aripiprazole for the Augmentation of Antidepressant Therapy September 2011 May 2013
NCT01188135 Completed Phase 3 Antidepressant Adherence Via AD_IVR February 2011 November 2014
NCT02948036 Completed N/A A Closed-loop Assessment and Treatment Platform for Unipolar Depression and Anxiety October 1, 2017 May 11, 2023
NCT01814085 Completed Phase 4 A Safety and Efficacy Study of Escitalopram on Acute Treatment of Severe Depression February 2010 March 2012
NCT02837887 Completed N/A Computerized Cognitive Behavior Therapy in Treating Depression in Patients With Cancer July 15, 2016 March 29, 2018
NCT00739908 Completed Phase 2 A Study of CX157 (TriRima) for the Treatment of Depression September 2008 July 2009
NCT03114891 Completed N/A Accelerated TMS to a Novel Brain Target in MDD and PTSD April 20, 2017 December 1, 2021
NCT00331799 Completed Phase 2 Pilot Study of Duloxetine in Psychological Resilience April 2007 July 2008
NCT01528748 Completed Clinical Trial of CBASP for Individuals With Co-occurring Chronic Depression and Alcohol Dependence April 2011 July 2018
NCT03429361 Completed Testing the Value of Smartphone Assessments of People With Mood Disorders August 8, 2017 May 30, 2019
NCT03749629 Completed N/A Comparative Effectiveness of Pharmacogenomics for Treatment of Depression May 1, 2019 March 15, 2022
NCT02218008 Completed Phase 3 A Study of ALKS 5461 for the Treatment of Major Depressive Disorder (MDD) - FORWARD-5 Study July 2014 October 2016
NCT01920490 Completed N/A Blame Rebalance fMRI Feedback Proof-of-concept May 2013 October 2014
NCT00232700 Completed N/A Investigation of a Combination Treatment of Escitalopram and rTMS September 2005 December 2008
NCT01360190 Completed Phase 4 Neurophysiologic Monitoring of Antidepressant Treatment August 1994 August 1996
NCT04985942 Completed Phase 3 Clinical Trial of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder July 30, 2021 February 27, 2024
NCT00321152 Completed Phase 4 A Study of 6(S)-5-MTHF Among Serotonin Reuptake Inhibitor(SSRI)-Resistant Outpatients With Major Depressive Disorder (MDD) November 2006 June 2010
NCT05425290 Completed N/A Emotion Regulation Training to Reduce Cardiovascular Disease Risk Among Depressed Young Adults in Southern Mississippi August 25, 2022 December 31, 2023
NCT00621270 Completed Phase 2 Safety and Effectiveness Study of BCI-540 Versus Placebo in the Treatment of Major Depressive Disorder With Concomitant Anxiety January 2008 October 2009
NCT02614326 Completed Phase 2 MemFlex to Prevent Depressive Relapse January 2016 December 2020
NCT00420004 Completed Phase 2 A Study for Participants With Major Depression December 2006 March 2008
NCT06114342 Completed The Biological Specificity of Acupoints Between Major Depressive Disorder Patients and Healthy Controls January 10, 2022 September 30, 2022
NCT01330485 Completed N/A Deficits in Emotion Regulation Skills as a Maintaining Factor in Major Depressive Disorder November 2010 September 2014
NCT03504475 Completed Phase 1 Bioequivalence Study of Paroxetine Tablets and Paxil® Under Fasting and Fed Conditions in Chinese Healthy Volunteers March 29, 2018 June 16, 2018
NCT02362529 Completed Early Phase 1 Biomarkers of Neuroinflammation and Anti-Inflammatory Treatments in Major Depressive Disorder February 2015 April 2019
NCT03925168 Completed N/A Music Therapy and Dialysis: A Pilot Investigation Into the Effectiveness of Patient-Selected Music Interventions on Physiological, Psychological, and Quality-of-Life Outcomes March 8, 2019 January 1, 2020
NCT02869035 Completed Phase 1 Treatment Outcome in Major Depressive Disorder August 2016 July 2019
NCT04981561 Completed Phase 1 Safety and Tolerability of GATE-251 in Normal Human Volunteers December 9, 2016 December 21, 2017
NCT02311725 Completed N/A Storytelling Video Intervention for Depressed Primary Care Patients - Pilot Trial May 1, 2017 March 1, 2019
NCT04747873 Completed N/A Incorporating Stepped Care Approach Into e-CBT for Depression April 7, 2021 July 19, 2023
NCT01034267 Completed Phase 3 Safety Study of F2695 SR in Major Depressive Disorder December 2009
NCT00130676 Completed Phase 3 A United States Study of Corlux for Psychotic Symptoms in Psychotic Major Depression September 2004 June 2006
NCT03357796 Completed Phase 1 Relative Bioavailability (RBA) Study of LY03005 vs Pristiq® November 27, 2017 December 22, 2017
NCT00369746 Completed STAR*D Alcohol: Treatment of Depression Concurrent With Alcohol Abuse September 2006 February 2009
NCT01582945 Completed N/A Ketamine Infusion for Treatment-resistant Major Depressive Disorder April 2012 December 2014
NCT03113890 Completed N/A McLean and Genomind Prospective Study September 22, 2017 July 31, 2020
NCT02860910 Completed N/A Cognitive Behavioral Group Therapy for the Management of Menopause Symptoms in Mood Disorders July 2016 October 2018
NCT01500200 Completed Phase 2 A Study to Evaluate ALKS 5461 in Subjects With Major Depressive Disorder (MDD) December 2011 March 2013
NCT01598922 Completed N/A Internet Based Cognitive Behavioral Therapy Effects on Depressive Cognitions and Brain Function October 2012 August 2015
NCT05535062 Completed N/A Study to Evaluate Treatment Effects Associated With the NeuroStar SoftStart Treatment Feature November 7, 2022 August 28, 2023
NCT02583867 Completed Phase 3 Predictors of Depression Treatment Response to Exercise December 2015 February 2019
NCT01085812 Completed Phase 3 Relapse-Prevention Study With Levomilnacipran ER (F2695 SR) in Patients With Major Depressive Disorder March 2010 October 2011
NCT00229294 Completed Fibromyalgia in Men Suffering From PTSD March 2004 March 2005
NCT03609190 Completed Early Phase 1 A Multimodal Neuroimaging Study of Brain Activation Patterns Under Ketamine January 2015 December 2018
NCT01254305 Completed Phase 2 Safety and Efficacy of Levomilnacipran ER (F2695 SR) in Adults With Fatigue Associated With Major Depressive Disorder April 2011 July 2012
NCT00191594 Completed Phase 3 Open-Label Duloxetine Extension Phase in Patients Who Have Completed Previous Duloxetine Trials March 2005 August 2006
NCT01601002 Completed Phase 4 LEPR Polymorphism Weight Gain by Mirtazapine in Late Life Depression June 2012 December 2015
NCT01589315 Completed Phase 2/Phase 3 Focal Electroconvulsive Therapy for Depression January 2007 August 2016
NCT03460574 Completed N/A Targeting Cognitive Immunization in Depression October 14, 2017 August 21, 2018
NCT01627782 Completed Phase 2 A Study of Ketamine in Patients With Treatment-resistant Depression August 6, 2012 September 12, 2013
NCT02330744 Completed N/A The Neurobiology of Approach Avoidance Training in Depression July 2014 July 2017
NCT01793324 Completed EMR Data to Assess Monitoring of Patients Treated With Quetiapine April 2012 June 2013
NCT01148472 Completed Phase 4 Efficacy and Tolerability of Escitalopram and Duloxetine in Outpatients With Major Depressive Disorder September 2005 November 2006
NCT01051466 Completed Phase 4 A Study of the Neurobiology of Depression January 2010 March 2013
NCT01894815 Completed Phase 3 Escitalopram, Placebo and tDCS in Depression: a Non-inferiority Trial October 2013 November 2016
NCT02801513 Completed N/A Maintaining Mechanisms of Chronic Depression and Their Changeability September 2013 March 2015
NCT00781677 Completed Using Neuroimaging to Investigate Major Depressive Disorder May 2008 January 20, 2011
NCT00384436 Completed Phase 4 Fixed Dose Comparison of Escitalopram to an Active Comparator in Severely Depressed Patients October 2006
NCT02805439 Completed Phase 2 Efficacy and Safety of S 47445 Versus Placebo as Adjunctive Treatment in Depressed Patients Not Fully Recovered From Depressive Symptoms With a Current Antidepressant Treatment March 2016 April 2017
NCT01121484 Completed Phase 4 Study Evaluating Desvenlafaxine Succinate Sustained-Release (DVS SR) In The Treatment Of Peri- And Postmenopausal Women With Major Depressive Disorder (DVS 3364) June 2010 June 2011
NCT00186446 Completed Phase 4 Treatment of Nicotine Dependence and Acute Depression June 2004 September 2007
NCT02460666 Completed N/A Brain Connectivity and Response to Tai Chi in Geriatric Depression January 2016 December 1, 2020
NCT01556048 Completed Phase 1 Pilot Study of Behavioral Activation for Prolonged Grief February 2009 May 2012
NCT01877447 Completed N/A Comparison of Two tDCS Protocols for the Treatment of Major Depressive Disorder July 2013 November 2013
NCT01185340 Completed Phase 3 A Study in Participants With Major Depressive Disorder Who Are Partial Responders to Selective Serotonin Reuptake Inhibitor March 2011 April 2013
NCT04838262 Completed N/A Stress and the Sympathetic Nervous System in Adults With Depression May 1, 2021 April 27, 2023
NCT02398877 Completed N/A HPA Axis Activity Due To Early Traumatic Stress and Metabolic Symptoms February 2013 February 2016
NCT02722967 Completed Phase 2 Exploratory Trial to Assess the Functionality of an Integrated Call Center for the Digital Medicine System March 2016 September 2016
NCT04158869 Completed An Investigation of the Relationship Between Omega-3 Fatty Acid Nutrition and Mental Health in Children and Adolescents September 16, 2019 December 22, 2020
NCT01309542 Completed Phase 3 Long-Term Safety Of DVS-233 SR In Patients With Major Depressive Disorder August 2003 March 2006
NCT04957368 Completed Phase 4 Sustained Mood Improvement With Laughing Gas Exposure: A Randomized Controlled Pilot Trial November 3, 2021 February 27, 2024
NCT00277823 Completed Phase 3 Study Evaluating Desvenlafaxine Sustained-Release (DVS-SR) in Adult Outpatients With Major Depressive Disorder February 2006 January 2007
NCT00870805 Completed Phase 4 Ultrabrief Pulsewidth Electroconvulsive Therapy (ECT) January 2009 January 2013
NCT04507243 Completed N/A Transcranial Direct Current Stimulation (tDCS) Therapy in Major Depression December 1, 2020 March 7, 2024
NCT03864614 Completed Phase 3 A Study to Evaluate SAGE-217 in Adult Participants With Major Depressive Disorder (MDD) February 27, 2019 June 22, 2023
NCT00688818 Completed N/A Quetiapine in Co-Morbid Depressive and Anxiety Disorders June 2008 June 2013
NCT00536471 Completed Phase 4 A Study Comparing Duloxetine and Placebo in Assessing Energy and Vitality in Major Depressive Disorder (MDD) Patients September 2007 December 2008
NCT02568865 Completed Noninvasive Physiologic Sensors to Assess Depression January 15, 2016 January 3, 2020
NCT00188942 Completed Phase 4 A Neuroimaging Investigation of Brain Activity in Major Depressive Disorder and Bipolar Disorder February 2005 June 2009
NCT05194267 Completed N/A Intensive tDCS for MDD: Feasibility Study February 2, 2022 August 16, 2023
NCT03414619 Completed N/A The Role of Cognitive Control in the Transdiagnostic Conceptualization of "Intrusive Thoughts" May 18, 2018 March 6, 2020
NCT06113575 Completed N/A Practical Application of Accelerated iTBS for MDD November 23, 2022 July 28, 2023
NCT03979040 Completed N/A Comparing Group Therapies for Veterans With Depression and PTSD February 3, 2021 March 30, 2024
NCT01860157 Completed N/A Deep rTMS for Treatment-Resistant Late-life Depression June 2013 December 2016
NCT00562367 Completed N/A Biochemical Brain Changes Correlated With The Antidepressant Effect Of Thyroid Hormones October 2001 September 2004
NCT02378714 Completed Phase 4 Behavioral Activation and Varenicline for Smoking Cessation in Depressed Smokers July 24, 2015 March 13, 2020
NCT03652597 Completed N/A Neuro-Cardiac-Guided Transcranial Magnetic Stimulation: Replication and Dose-response. March 6, 2018 May 2, 2019
NCT04031937 Completed N/A Sensory and Psychomotor Profile in Depression October 23, 2018 October 15, 2019
NCT04504253 Completed Phase 3 A Pilot Study of Creatine Monohydrate as an Augmenting Agent for ECT in Persons With Major Depressive Disorder August 3, 2020 August 2, 2023
NCT02421965 Completed N/A Comparing Mobile Health (mHealth) and Clinic-Based Self-Management Interventions for Serious Mental Illness June 2015 December 2017
NCT00422162 Completed Phase 4 A Study Evaluating Duloxetine in Patients Hospitalized for Severe Depression February 2007 August 2008
NCT00831415 Completed Phase 3 Study Evaluating Long-Term Safety of Desvenlafaxine Succinate Sustained Release With Japanese Adult Subjects in Major Depressive Disorder (MDD) March 2009 March 2011
NCT02507219 Completed Phase 2/Phase 3 Study of Ibuprofen Effects on Brain Function July 2015 October 2015
NCT05855850 Completed N/A Deep rTMS for Depression in Older Adults April 18, 2023 June 3, 2024
NCT01479920 Completed N/A A Positron Emission Topographic (PET) Study on Depression Patient With Electroacupuncture June 2012 May 2015
NCT02334228 Completed N/A Evaluation of the In SHAPE Fitness Intervention for Adults With Serious Mental Illness September 2006 August 2009
NCT01395147 Completed Phase 3 Long-Term Extension Study of Lu AA21004 in Participants With Major Depressive Disorder July 2011 May 2013
NCT02860962 Completed Phase 1 A Trial of Dextromethorphan for Treatment of Major Depressive Disorder August 2016 June 2017
NCT02443584 Completed N/A Pharmacogenetic Testing on an Outpatient Population With a Depression Diagnosis February 1, 2015 April 1, 2017
NCT05695365 Completed N/A Feasibility of Resistance Exercise to Treat Major Depression Via Cerebrovascular Mechanisms April 4, 2022 January 10, 2023
NCT00095823 Completed Phase 3 A Study of Adjunctive Aripiprazole in Patients With Major Depressive Disorder June 2004 August 2006
NCT02934334 Completed Wellness Monitoring for Major Depressive Disorder May 31, 2016 February 25, 2019
NCT01221935 Completed Retrospective Study Evaluating The Current Utilization Of Desvenlafaxine Succinate Sustained-Release (Pristiq) Among Psychiatrists And Primary Care Physicians In The Treatment Of Patients With Major Depressive Disorder September 2009 January 2010
NCT04294654 Completed Phase 4 Vortioxetine in Patients With Depression and Early Dementia February 28, 2020 July 20, 2022
NCT00692445 Completed Phase 2 TC-5214 as add-on the Treatment of Major Depressive Disorder June 2008 July 2009
NCT01342120 Completed PHARMO Institute Seroquel Safety Study September 2010 November 2010
NCT04510519 Completed Scaling Mental Healthcare in COVID-19 With Voice Biomarkers January 12, 2022 March 2, 2022
NCT03595579 Completed Phase 2 Assessing Symptomatic Clinical Episodes in Depression May 30, 2018 January 7, 2019
NCT00373477 Completed N/A A Study of the Cost Effectiveness of Generalist Care Managers for Depression Treatment in Medicaid Recipients July 2003 February 2005
NCT00731653 Completed Phase 2 Open Label Extension Assessing the Tolerability of BCI-024 in Combination With BCI-049 in Patients With Major Depressive Disorder (MDD) July 2008 January 2009
NCT05016050 Completed N/A Digital Therapeutic for Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD) August 9, 2021 April 14, 2023
NCT01582815 Completed Phase 2 A Study of JNJ-40411813 as Supplementary Treatment to an Antidepressant in Adults With Depression and Anxiety Symptoms September 2012 November 2013
NCT04529694 Completed N/A Patient Characteristics and Cognitive vs. Behavioral Therapies for Depression October 20, 2011 June 26, 2012
NCT01808651 Completed Phase 3 A Study of Fluoxetine in Major Depressive Disorder (MDD) Long-Term Dosing May 2013 March 2015
NCT03430869 Completed Phase 2 Pathophysiology of Neurodegeneration in Late-life Depression (AV45+THK) March 23, 2018 December 31, 2021
NCT02480400 Completed N/A The Effect of Patient and Investigator Expectation on the Efficacy of Escitalopram in the Treatment Depression June 2010 October 2012
NCT02458690 Completed Phase 2 eIMPACT Trial: Modernized Collaborative Care to Reduce the Excess CVD Risk of Older Depressed Patients July 2015 March 2021
NCT01882829 Completed Phase 2 Nuedexta in Treatment-Resistant Major Depression July 2013 March 2016
NCT02279953 Completed Phase 3 Efficacy of Vortioxetine on Cognitive Dysfunction in Patients With Partial or Full Remission of Major Depressive Disorder October 2014 April 2016
NCT00924976 Completed N/A Improving Representative Payeeship for People With Psychiatric Disabilities and Their Families May 2008 April 2011
NCT03051074 Completed N/A Examining the Effects of Reduced Environmental Stimulation on Anxiety December 1, 2016 December 31, 2019
NCT04395183 Completed Phase 2 5-HTP and Creatine for Depression March 1, 2021 March 1, 2024
NCT02479464 Completed N/A Clinical Impact of the Antidepressant Pharmacogenomic Algorithm in an Outpatient Therapy-based Clinical Setting October 2009 August 2014
NCT01973478 Completed N/A Deep Brain Stimulation in Patients With Chronic Treatment Resistant Depression June 3, 2014 November 27, 2018
NCT01342536 Completed Phase 3 African American Depression Intervention Trial (AADI) December 14, 2011 June 2018
NCT04467164 Completed N/A Vagus Nerve Stimulation: Integration of Behavior and Cardiac Modulation April 15, 2015 September 22, 2018
NCT03571412 Completed N/A Antidepressive Effect on 5 Herz (Hz) rTMS Over Dorsomedial Prefrontal Cortex and Left Dorsolateral Prefrontal Cortex August 8, 2016 September 1, 2017
NCT00609453 Completed N/A Brain Imaging of Psychotherapy for Depression October 2006 January 2008
NCT02429011 Completed MRI Studies of Emotion in Depression July 15, 2011 May 31, 2016
NCT00035321 Completed Phase 3 The Study of Olanzapine Plus Fluoxetine in Combination for Treatment of Treatment Resistant Depression April 2002 July 2005
NCT01633437 Completed Phase 1 Oral Tyramine Pressor Response Study of CX157 Tablets in Healthy Male Volunteers September 2010 October 2010
NCT01153347 Completed Phase 3 A Study to Assess the Efficacy and Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder June 2010 January 2012
NCT02939560 Completed N/A TMS for Adults With Autism and Depression September 2016 September 20, 2018
NCT00909155 Completed N/A Brain Imaging Techniques That Predict Antidepressant Responsiveness July 2002 December 2009
NCT03307070 Completed N/A Adapted Cognitive Behavioral Treatment for Depression in Patients With Moderate to Severe Traumatic Brain Injury September 23, 2017 November 28, 2022
NCT02674529 Completed Phase 2/Phase 3 Study of Neural Responses Induced by Antidepressant Effects September 2016 May 2021
NCT00694304 Completed Phase 3 Open-label Safety Extension Study of 2.5, 5 and 10 mg of Vortioxetine (Lu AA21004) in Long-term Treatment of Major Depressive Disorder in Adults May 2008 April 2010
NCT00042562 Completed Phase 3 Open-Label Treatment With Duloxetine Hydrochloride Once-Daily Dosing for Evaluation of Stabilization Dose in Patients With Major Depression December 2002 December 2003
NCT02685982 Completed N/A Treating Major Depressive Disorder With Music and Low-frequency Rhythmic Sensory Stimulation April 2016 August 2017
NCT04478058 Completed N/A Feasibility and Effectiveness of Delivering CBT Through OPTT for Depression June 1, 2019 September 30, 2021
NCT01567943 Completed N/A Contingency Management of Alcohol Abuse in the Severely Mentally ILL March 2012 February 2016
NCT03893162 Completed N/A Gut Feeling: Understanding the Mechanisms Underlying the Antidepressant Properties of Probiotics July 1, 2019 June 30, 2022
NCT01263106 Completed Phase 1 A Study of LY2216684 and Theophylline in Healthy Subjects December 2010 January 2011
NCT03062267 Completed N/A Effectiveness of a Mobile Texting Intervention for People With Serious Mental Illness October 1, 2017 May 31, 2020
NCT02283541 Completed N/A Gait, Depression, and Mind-body Therapy in Seniors June 2015 January 2017
NCT02959307 Completed N/A Transcranial Laser Therapy, Continuous and Pulsed Light, for Major Depressive Disorder (ELATED-3) November 2016 November 2018
NCT01919216 Completed Phase 4 Placebo Effects in the Treatment of Depression: Cognitive and Neural Mechanisms January 2010 June 2016
NCT03143075 Completed N/A Do Omega-3 Fatty Acids Have an Antidepressant Effect in Patients With Signs of Peripheral Inflammation? August 1, 2017 May 9, 2023
NCT02476058 Completed Phase 1 A Safety, Efficacy and Biomarker Study of JNJ-42847922 in Participants With Major Depressive Disorder June 11, 2015 January 4, 2016
NCT00927173 Completed N/A Evaluation of the Brainsway Deep Transcranial Magnetic Stimulation (TMS) H-Coil in the Treatment of Major Depression Disorder September 2009 June 2012
NCT01207271 Completed N/A A Comparison of Cognitive and Dynamic Therapy for Depression in Community Settings November 2010 December 9, 2014
NCT05376150 Completed Phase 2 A Study to Evaluate the Safety, Tolerability and Efficacy of XEN1101 in Major Depressive Disorder May 19, 2022 October 16, 2023
NCT01000805 Completed Phase 4 A Study of Duloxetine in Major Depressive Disorder (MDD) and Associated Painful Symptoms November 2009 October 2010
NCT00952653 Completed Phase 4 Study Evaluating the Effect of Desvenlafaxine on the Pharmacokinetics of Midazolam June 2010 August 2010
NCT02125799 Completed Phase 2/Phase 3 Accelerated rTMS for Treatment-Resistant Major Depression October 2012 December 2013
NCT01145872 Completed Phase 3 The Effects and Mechanisms of Mindfulness Based Cognitive Therapy (MBCT) on Depressive Symptoms and Depression Relapse July 2010 April 2013
NCT01874951 Completed Phase 2 Low-Dose Naltrexone (LDN) for Depression Relapse and Recurrence June 2013 June 2015
NCT00087737 Completed Phase 3 Study Evaluating DVS-233 SR and Venlafaxine ER in Adult Outpatients With Major Depressive Disorder May 2005
NCT02972632 Completed Phase 4 Goal Achievement After a Change to Vortioxetine in Adults With Major Depressive Disorder December 22, 2016 February 6, 2018
NCT02188121 Completed Phase 4 Fixed Dose Intervention Trial of New England Enhancing Survival in SMI Patients February 2015 October 2021
NCT00590863 Completed Phase 4 Combining Medications to Enhance Depression Outcomes March 2008 September 2009
NCT03053830 Completed Phase 2 Open Label Ketamine Treatment for Major Depressive Disorder in Veterans January 31, 2017 September 26, 2018
NCT01931202 Completed N/A Mechanisms of Antidepressant Non-Response in Late-Life Depression February 19, 2014 January 17, 2020
NCT00668525 Completed Phase 3 Escitalopram in Adult Patients With Major Depressive Disorder April 2008
NCT01173601 Completed Phase 3 A Fixed Dose Study of Adjunctive Treatment to Antidepressant Therapy for Adults With Major Depressive Disorder November 2010 October 2013
NCT01371721 Completed Phase 3 A 6-Month Open-Label Extension Study to the B2061014 Study to Evaluate the Safety, Tolerability and Efficacy of DVS SR in the Treatment of Children and Adolescents With MDD February 2012 October 2015
NCT03780881 Completed N/A EXperimental Paradigm to Investigate Expectation Change in Depression 4 November 11, 2018 August 31, 2019
NCT01808612 Completed Phase 3 A Study of Fluoxetine in Major Depressive Disorder (MDD) Short-Term Dosing March 2013 July 2014
NCT00505518 Completed N/A Investigating the Effectiveness of Telepsychiatry for Treating Major Depression in a Chinese American Nursing Home September 2006 November 2007
NCT00377299 Completed N/A A Pilot Study of Citicoline add-on Therapy in Patients With Bipolar Disorder or Major Depressive Disorder and Amphetamine Abuse or Dependence October 2006 May 2009
NCT04889976 Completed N/A Portable Transcranial Electrical Stimulation and Internet-Based Behavioral Therapy for Major Depression Study May 22, 2021 October 21, 2022
NCT03446846 Completed Phase 2 A Study to Evaluate the Efficacy and Safety of MIN-117 in Adult Patients With Major Depressive Disorder March 30, 2018 December 13, 2019
NCT04633096 Completed N/A The Efficacy of Automated Feedback After Internet-based Depression Screening January 12, 2021 September 30, 2022
NCT01075529 Completed Phase 4 Early Prediction of Fluoxetine Response March 2007 February 2010
NCT01409304 Completed Phase 2/Phase 3 Effectiveness of Deep Transcranial Magnetic Stimulation in Depression October 2011 December 2012
NCT01919008 Completed Phase 1 Comparison of Plasma Concentration Changes Between Two Types of Tablets of FK949E Administration to Patients With Major Depressive Disorder March 26, 2012 June 22, 2012
NCT00578383 Completed N/A Low Field Magnetic Stimulation in Mood Disorders Using the LFMS Device November 2007 March 2013
NCT01217645 Completed Phase 1 Study to Assess the Distribution, Metabolism and Excretion of [14C]AZD6765 After a Single-Dose Intravenous Administration September 2010 October 2010
NCT00209105 Completed Characterizing Psychological Consequences of Childhood Trauma January 2005 March 2011
NCT01558063 Completed Phase 2 Ketamine in the Treatment of Depression February 2012 October 2019
NCT03113968 Completed Phase 2/Phase 3 ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD) April 7, 2017 November 17, 2022
NCT05260086 Completed N/A Pre-mapping Networks for Brain Stimulation 2 April 15, 2019 May 12, 2022
NCT02086929 Completed Phase 3 Trazodone Once a Day in Major Depression Disorder December 2012 April 2014
NCT02139540 Completed Phase 2 Nitrous Oxide as Treatment for Major Depression - a Pilot Study November 2012 April 2015
NCT00215228 Completed Phase 2/Phase 3 Effects of Duloxetine vs. Escitalopram on Heart Rate Variability in Depression July 2005 August 2007
NCT02522377 Completed N/A Administration of Subanesthetic Dose of Ketamine and Electroconvulsive Treatment for Treatment Resistant Depression August 2015 March 1, 2018
NCT00782964 Completed Antidepressant Incomplete Response Depression October 2008 November 2009
NCT02409823 Completed Clinical Registry of Patients Under Treatment With Atypical Antipsychotics February 2015 August 2015
NCT01191333 Completed N/A The Effectiveness of rTMS in Depressed VA Patients July 2, 2012 March 31, 2017
NCT05385783 Completed Phase 1/Phase 2 A Study of a Psilocybin Analog (CYB003) in Healthy Participants With and Without Major Depressive Disorder August 2, 2022 January 18, 2024
NCT01415154 Completed N/A Maintenance NeuroStar Transcranial Magnetic Stimulation (TMS) in Patients With Major Depressive Disorder August 2011 July 2014
NCT01070329 Completed Phase 4 A Study in Depression and Associated Painful Physical Symptoms March 2010 March 2011
NCT01721824 Completed N/A The Effect of IPS-MA- A Modified Early Supported Employment Intervention for Individuals With Mood or Anxiety Disorders October 2011 July 2016
NCT00521352 Completed Phase 2 Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Panic Disorder With Comorbid Major Depression October 2007 June 2011
NCT00943033 Completed N/A Study of Mindfulness-Based Cognitive Therapy August 2009 July 2010
NCT00406848 Completed Phase 4 A Study Comparing the Efficacy and Safety of Duloxetine and Placebo for the Treatment of Depression in Elderly Patients November 2006 November 2009
NCT02361684 Completed N/A e-Compared-S: Comparative Effectiveness Research on Internet-based Depression Treatment - Spanish Trial February 2015 September 2019
NCT00095758 Completed Phase 3 A Study of Adjunctive Aripiprazole in Patients With Major Depressive Disorder September 2004 December 2006
NCT02369393 Completed N/A Efficacy of Two Internet Delivered Intervention Programs for Depression: Behavioral Activation vs Physical Activity November 2, 2021 February 1, 2023
NCT01082237 Completed Phase 4 Biomarkers for Outcomes In Late-life Depression (BOLD) October 2009 October 2012
NCT00839423 Completed Phase 2 Randomised Placebo-controlled Venlafaxine-referenced Study of Efficacy and Safety of 5 and 10 mg of Vortioxetine (Lu AA21004) in Acute Treatment of Major Depressive Disorder in Adults August 2006 September 2007
NCT03594773 Completed N/A Modeling Multi-level Dyadic Behavior to Transform the Science and Practice of Psychotherapy Process and Outcome. July 8, 2018 July 31, 2021
NCT03449979 Completed N/A Single Session of tACS in a Depressive Episode September 19, 2018 August 16, 2019
NCT04623814 Completed Phase 1 the Safety, Tolerability, and Pharmacokinetics Study of HEC113995 March 30, 2020 August 12, 2020
NCT05525390 Completed N/A Extended Reality Behavioral Activation: An Intervention for Major Depressive Disorder December 19, 2022 July 24, 2023
NCT01370733 Completed Phase 3 Synchronized Transcranial Magnetic Stimulation (sTMS) in Major Depressive Disorder May 2012 September 2013
NCT01263119 Completed Phase 1 A Study of LY2216684 and Warfarin in Healthy Subjects December 2010 February 2011
NCT03742960 Completed N/A Sleep Subtypes in Adolescent Depression April 24, 2019 July 1, 2023
NCT02158533 Completed Phase 3 A Study of ALKS 5461 for the Treatment of Major Depressive Disorder (MDD) - the FORWARD-4 Study May 2014 December 2015
NCT01542957 Completed N/A Cognitive Therapy for Unipolar Depression: Efficacy of a Dilemma-Focused Intervention November 2011 May 2015
NCT01975948 Completed N/A Evaluation of a Mental Health Physician Support Program in Nova Scotia November 2013 December 2015
NCT05952713 Completed Comparative Responses to 15 Different Antidepressants in Major Depressive Disorder October 1, 2022 July 1, 2023
NCT00784199 Completed Validating PROMIS Instruments in Depression June 2008 July 2010
NCT01454635 Completed N/A Analisis of Facors Involved in Antidepressant Treatment Response of Major Depressive Disorder June 2008 March 2010
NCT01381107 Completed Phase 1/Phase 2 ALK33BUP-201: Safety and Tolerability Study of ALKS 33-BUP (ALKS 5461) Administration in Subjects With MDD May 2011 July 2011
NCT01385709 Completed The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels August 2008 August 2013
NCT04698603 Completed Phase 1/Phase 2 Clinical Study of GH001 in Depression November 12, 2019 November 6, 2021
NCT01371708 Completed Phase 3 A 6-Month Extension Study To The B2061032 Study To Evaluate The Safety, Tolerability, And Efficacy Of DVS SR In The Treatment Of Child And Adolescent Outpatients With MDD February 2, 2012 April 22, 2016
NCT02176226 Completed N/A IntelliCare: Artificial Intelligence in a Mobile Intervention for Depression and Anxiety (AIM) March 2015 June 2016
NCT01818453 Completed N/A Can Genetics Predict Treatment Response to a Computerized Self-help Program for Depression? March 2013 November 2015
NCT01692574 Completed N/A Treatment for Depressed, Obese Individuals at Risk for Cardiovascular Disease (CVD) August 2012 November 2015
NCT02141399 Completed Phase 3 A Long-Term Safety Study of ALKS 5461 May 2014 November 20, 2017
NCT04855760 Completed Phase 3 Safety of REL-1017 for Major Depressive Disorder April 1, 2021 July 27, 2023
NCT00745017 Completed Phase 1 Stress Generation and Recurrent Depression: The Role of Differential Treatment Response July 2001
NCT04933630 Completed Tracking Response to Antidepressants in Advance of Investigational Trials, Relapse Study June 1, 2021 October 5, 2022
NCT00479726 Completed Phase 4 Lilly's Emotional and Physical Symptoms of Depression Study (LEAPS) August 2004 January 2005
NCT02332954 Completed Phase 4 Assessment in Work Productivity and the Relationship With Cognitive Symptoms in Patients With MDD Taking Vortioxetine February 2015 July 6, 2017
NCT01691092 Completed N/A PET Imaging of mGLuR5 With Drug Challenge June 2012 February 2016
NCT00818506 Completed Associations Between Depression and Cardiovascular Disease - a Study of Patients With Late Onset Depression March 2009 June 2012
NCT04621786 Completed N/A Electroconvulsive Therapy Amplitude Titration March 1, 2021 December 15, 2022
NCT01487668 Completed N/A Life Goals Collaborative Care to Improve Health Outcomes in Mental Disorders December 2011 May 2015
NCT00871299 Completed N/A Practicing Alternative Techniques to Heal From Depression: The PATH-D Study September 2009 June 2014
NCT01457677 Completed Phase 2 ARTDeCo Study: A Study of RO4995819 in Patients With Major Depressive Disorder And Inadequate Response to Ongoing Antidepressant Treatment December 2011 June 2014
NCT01275144 Completed Phase 1 A Study of the Effect of LY2216684 on Lorazepam December 2010 February 2011
NCT03310281 Completed N/A Software Treatments for Actively Reducing Severity of Cognitive Deficits in MDD (STARS-MDD) December 4, 2017 November 14, 2018
NCT00208169 Completed Phase 4 Abilify Therapy for Reducing Comorbid Substance Abuse March 2005 June 2007
NCT01370499 Completed Phase 3 A Study of LY2216684 in Participants With Major Depression Disorder August 2011 January 2014
NCT04768361 Completed N/A Behavioral Activation for Major Depression With and Without Mindfulness August 10, 2020 April 27, 2021
NCT05157945 Completed Phase 2 ALTO-300 in Depression (ALTO-300-004) February 3, 2022 May 5, 2023
NCT04437485 Completed Phase 2 eIMPACT-DM Pilot Trial: Depression Treatment to Reduce Diabetes Risk October 14, 2020 August 29, 2022
NCT02158546 Completed Phase 3 A Study of ALKS 5461 for the Treatment of Major Depressive Disorder (MDD) - the FORWARD-3 Study May 2014 December 2015
NCT01075295 Completed N/A Prevention of Weight Gain in Early Psychoses February 2010 December 2012
NCT01878292 Completed Phase 3 Safety and Efficacy of Vilazodone in Adolescent Patients With Major Depressive Disorder July 11, 2013 October 5, 2016
NCT04355650 Completed N/A Augmented Human Intelligence in Major Depressive Disorder January 27, 2020 December 2, 2022
NCT00485420 Completed N/A eCare for Moods: An Internet-based Management Program September 2002 December 2009
NCT02470026 Completed N/A Noradrenergic Activity, Cognition and Major Depressive Disorder June 2014 October 2018
NCT02133001 Completed Phase 2 A Double-blind Study to Assess the Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Participants Who Are Assessed to be at Imminent Risk for Suicide May 23, 2014 February 1, 2016
NCT01517503 Completed N/A Acceptance and Commitment Therapy Versus Cognitive Therapy for the Treatment of Major Depressive Disorder December 2011 August 2015
NCT00125554 Completed Phase 2 Metyrapone as Additive Treatment in Major Depression May 1998 July 2001
NCT00939250 Completed Phase 4 A Comprehensive Intervention for Diabetes and Comorbid Depression in Primary Care October 2009 December 2011
NCT00761306 Completed Phase 2 Open-label Safety Extension Study of 5 and 10 mg of Vortioxetine (Lu AA21004) in Long-term Treatment of Major Depressive Disorder in Adults June 2007 October 2008
NCT01263197 Completed Phase 1 A Study of LY2216684 in Healthy Participants Receiving Albuterol or Propanolol December 2010 March 2011
NCT03739203 Completed Phase 3 The Objective of This Study is to Evaluate the Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD) Who Have Had an Inadequate Response to Antidepressants Alone November 10, 2018 September 6, 2021
NCT05866042 Completed N/A Boosting Psychotherapy Effects by Means of Transcranial Direct Current Stimulation May 1, 2021 April 30, 2023
NCT00561509 Completed Multi-Country Observational Study to Collect the Frequency of Sexual Dysfunction With Antidepressant Treatment, Either With SSRIs or Duals at 8 Weeks and 6 Months November 2007 June 2009
NCT02473783 Completed Phase 2 The Serotonin Transporter Availability for Prognosing Major Depressive Disorder (MDD) Treatment and Detecting MDD October 2011 November 2012
NCT04673383 Completed Phase 1/Phase 2 SPL026 (DMT Fumarate) in Healthy Subjects and MDD Patients February 4, 2021 December 22, 2022
NCT03624933 Completed N/A Effects of Cannabis Abstinence on Symptoms and Cognition in Depression November 6, 2017 December 30, 2019
NCT01685294 Completed Phase 3 Effectiveness of Interpersonal Psychotherapy (IPT) for Men and Women Prisoners With Major Depression December 2011 October 2014
NCT00578669 Completed Phase 3 Sequential Use of Fluoxetine for Smokers With Elevated Depressive Symptoms April 2008 November 2013
NCT02014363 Completed Phase 2 Safety and Efficacy Study Comparing ETS6103 With Amitriptyline in the Treatment of Major Depressive Disorder (MDD) October 2013 October 2015
NCT00452543 Completed Phase 4 Acamprosate Added to Escitalopram and Behavioral Treatment for Comorbid Depression and Alcoholism March 2007 May 2010
NCT02744391 Completed Phase 4 A Study of L-DOPA for Depression and Slowing in Older Adults August 24, 2016 November 30, 2018
NCT00095745 Completed Phase 3 A Long-Term Study of Aripiprazole in Patients With Major Depressive Disorder September 2004 November 2007
NCT01488071 Completed Phase 3 A Study of Vortioxetine (Lu AA21004) in Comparison to Agomelatine in Adults Suffering From Major Depression With Inadequate Response to Previous Medication January 2012
NCT04891224 Completed N/A Use of a Digitally Enabled App With Clinical Team Interface in the Management of Depression February 19, 2021 January 30, 2023
NCT00168272 Completed N/A Priming rTMS In Major Depression June 2004 March 2007
NCT01936506 Completed Phase 1/Phase 2 Cognitive Training for Depression July 2010 October 2012
NCT04055181 Completed N/A Influence of rTMS on Symptoms and Cognitive Function in Patients With Psychiatric Disorders December 1, 2018 January 30, 2020
NCT02356107 Completed Phase 4 5-hydroxytryptophan and Creatine for Treatment Resistant Depression Associated With Hypoxia in Females April 2015 August 2016
NCT05720637 Completed N/A The Efficacy and Cerebral Mechanism of Intradermal Acupuncture for Major Depressive Disorder November 1, 2022 January 1, 2024
NCT01149213 Completed Phase 2/Phase 3 Follow-up Study of Transcranial Direct Current Stimulation to Treat Major Depressive Disorder June 2010 March 2012
NCT03899285 Completed Phase 2 Citalopram Titration in Early Non-responder Patients With Major Depressive Disorders January 8, 2018 December 8, 2018
NCT02376257 Completed Phase 2 Improving Therapeutic Learning in Depression: Proof of Concept September 16, 2014 May 2017
NCT02809677 Completed N/A Treating Caregiver Depression to Improve Childhood Asthma: Impact and Mediators June 2016 October 2020
NCT02371291 Completed Phase 1/Phase 2 Memory Flexibility Training for Depression January 2015 January 2017
NCT04721249 Completed N/A D-serine Supplementation for Depression July 1, 2021 January 30, 2024
NCT02230592 Completed PET Imaging of Brain mGluR1 Receptors Using [18F]FIMX November 8, 2013 June 16, 2016
NCT01882608 Completed N/A Using Mental Health Telemetry to Predict Relapse and Re-hospitalization in Mood Disorders October 2013 March 2016
NCT02440815 Completed N/A Multimodal MRI Characteristics of Psychotherapy Response in Late Life Depression November 2015 July 28, 2021
NCT02214511 Completed Biomarkers of Social Sensitivity in Major Depression October 23, 2014 March 1, 2017
NCT04638231 Completed N/A Supportive Text Messaging Versus Supportive E-mail Messaging for Patients With Major Depressive Disorder April 8, 2021 December 15, 2023
NCT02185131 Completed Phase 2 Double-blind Pilot Trial of Mirtazapine for the Treatment of Co-occurring AD/MDD. September 2013 July 2016
NCT02176291 Completed Phase 2 Incomplete Response in Late-Life Depression: Getting to Remission With Buprenorphine August 2014 February 2018
NCT00998959 Completed N/A Stress Reduction Intervention for Enhancing Treatment Outcome for Depressed Minority Patients August 2008 January 2012
NCT04799405 Completed N/A Home-based tDCS in Major Depressive Disorder September 24, 2020 July 2, 2021
NCT00025974 Completed Brain Chemical Receptor Effects in Patients With Panic Disorder and Post-Traumatic Stress Disorder October 31, 2001 July 21, 2008
NCT02661789 Completed N/A Neuropsychobiological Correlates of Sex-steroid Hormone Manipulation in Healthy Women: a Risk Model for Depression January 2011 December 2012
NCT00885222 Completed N/A Antidepressant Effect of Deep Brain Stimulation in Parkinson's Disease Patients May 2009 May 2010
NCT03716869 Completed N/A Universal vs. Targeted School Screening for Adolescent Major Depressive Disorder November 6, 2018 February 3, 2021
NCT01269710 Completed Second-Generation Antipsychotic Treatment Indication Effectiveness And Tolerability In Youth (Satiety) Study October 2009 March 2011
NCT01659814 Completed Dopamine Neurotransmission in Major Depression March 2011 December 2012
NCT01724112 Completed Phase 2 Study of the Efficacy and Safety of LY2940094 in Participants With Major Depressive Disorder (MDD) November 2012 March 2014
NCT05597241 Completed Phase 1 Multiple Ascending Dose and Electroencephalography Trial of GATE-202 in Healthy Volunteers October 15, 2022 April 4, 2023
NCT01421342 Completed Phase 3 VA Augmentation and Switching Treatments for Improving Depression Outcomes December 2012 June 2016
NCT01250873 Completed Phase 1 A Pharmacokinetic Study of the Coadministration of LY2216684 With Sertraline November 2010 January 2011
NCT00849693 Completed Phase 3 A Study in the Treatment of Children and Adolescents With Major Depressive Disorder March 2009 September 2011
NCT00633399 Completed Phase 2 Ziprasidone Augmentation of SSRIs for Patients With Major Depressive Disorder (MDD) That do Not Sufficiently Respond to Treatment With SSRIs July 2008 March 2014
NCT02279966 Completed Phase 3 Efficacy of Vortioxetine on Cognitive Dysfunction in Working Patients With Major Depressive Disorder October 2014 February 2016
NCT02165449 Completed Phase 1 Biomarkers of Fast Acting Therapies in Major Depression June 2014 August 2019
NCT03785652 Completed Phase 1 Dose-Finding Clinical Trial to Evaluate the Efficacy and Safety of LY03005 Extended-release Tablets in the Treatment of Major Depressive Disorder (MDD) October 9, 2015 October 31, 2015
NCT02669082 Completed Phase 4 The Exploratory Study to Investigate the Effect of Ramelteon for Insomnia Patients With Major Depressive Disorder by Using Actigraphy May 9, 2017 January 31, 2018
NCT04019704 Completed Phase 3 A Trial of AXS-05 in Patients With Major Depressive Disorder June 20, 2019 December 5, 2019
NCT01573598 Completed Phase 4 Safety and Efficacy of Vilazodone in Major Depressive Disorder April 2012 January 2015
NCT01110902 Completed Phase 3 Efficacy, Safety and Tolerability of Agomelatine Sublingual Tablets in the Treatment of Major Depressive Disorder (MDD) May 2010 June 2011
NCT02309060 Completed N/A Storytelling Video Intervention for Depressed Primary Care Patients - Open Trial September 2016 March 1, 2017
NCT02407704 Completed Phase 4 A Multi-level Life-span Characterization of Adult-depression and Effects of Medication and Exercise March 2015 December 2016
NCT05118750 Completed Phase 2 ALTO-300 in Depression December 13, 2021 May 9, 2023
NCT00226278 Completed Phase 2 Safety Study of ORG 34517 for Major Depression With Psychotic Features September 2004 November 2005
NCT01446692 Completed Badalona Major Depressive Disorder Database Study November 2011 January 2012
NCT04068467 Completed N/A Evaluation of mHealth for Serious Mental Illness January 6, 2020 May 1, 2021
NCT00000375 Completed Phase 4 Continuation Electroconvulsive Therapy Vs Medication to Prevent Relapses in Patients With Major Depressive Disorder February 1997
NCT01947647 Completed N/A Transdiagnostic Psychotherapy for Veterans With Mood and Anxiety Disorders November 17, 2014 December 31, 2018
NCT00863798 Completed Phase 3 Study Evaluating Desvenlafaxine Succinate Sustained Release In Adults With Major Depressive Disorder April 2009 March 2010
NCT05084924 Completed N/A Investigating the Causal Role of Prefrontal Control in Decision-making in Patients With Anhedonia November 2, 2021 July 31, 2023
NCT00048594 Completed Phase 3 Long Term Treatment of Patients With Major Depressive Disorder With MK0869 (0869-065)(COMPLETED) January 3, 2002 December 22, 2003
NCT00798707 Completed Phase 3 Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) in the Treatment of Major Depressive Disorder December 2008 April 2010
NCT00128505 Completed Phase 3 An International Extension Study of Corlux for Recurrent Psychotic Symptoms in Psychotic Major Depression August 2005 November 2006
NCT02055300 Completed Phase 1 Safety, Tolerability and Pharmacokinetics Study of LY03005 February 2014 August 2014
NCT01035073 Completed Phase 4 Functional Change and Efficacy of Duloxetine in Patients With Co-Morbid Depression & Soft Tissue Discomfort Syndrome April 2006 May 2009
NCT01559857 Completed Phase 4 Pioglitazone in Patients With Mood Disorders November 2011 June 2014
NCT01263223 Completed Phase 1 A Study of LY2216684 in Major Depressive Disorder in Patients Taking Selective Serotonin Reuptake Inhibitors December 2010 March 2011
NCT02308956 Completed Phase 3 Task Sharing for the Care of Severe Mental Disorders in a Low-income Country March 2015 November 16, 2017
NCT02815813 Completed N/A Lifestyle Intervention for Young Adults With Serious Mental Illness July 3, 2017 May 31, 2022
NCT04471818 Completed Phase 1/Phase 2 Ketamine or Placebo in Patients With Major Depression and Advanced Cancer September 19, 2019 July 30, 2023
NCT01140906 Completed Phase 3 Randomised Placebo-controlled Duloxetine-referenced Study of Efficacy and Safety of 15 and 20 mg of Vortioxetine (Lu AA21004) in Acute Treatment of Major Depressive Disorder in Adults May 2010
NCT01416220 Completed Phase 4 Lithium Versus Paroxetine in Major Depression September 2011 February 2013
NCT00432614 Completed Phase 3 Efficacy and Safety of SR58611A co-Administered With Escitalopram in Adults With Major Depressive Disorder January 2007 February 2008
NCT03591224 Completed N/A Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy April 17, 2018 December 31, 2019
NCT02266693 Completed N/A Transdiagnostic iCBT for Depression and Anxiety August 2014 August 2018
NCT01441440 Completed Phase 3 Venlafaxine ER Phase 3 Study for Major Depressive Disorder (MDD) November 2011 March 2014
NCT04608396 Completed Phase 2 Mechanistic Evaluation of Response in TRD (MERIT) August 13, 2020 July 30, 2021
NCT02066077 Completed N/A The Efficacy And Cognitive Impairment Of Modified Electroconvulsive Therapy January 1, 2013 December 31, 2017
NCT01043289 Completed N/A Light Therapy for Depression During Pregnancy October 2004 October 2008
NCT04589143 Completed Phase 4 A Double-blind, Placebo-controlled Study of Antidepressant Augmentation With Agomelatine October 1, 2020 January 30, 2023
NCT00810069 Completed Phase 4 Early Versus Delayed Switch in Medication in Patients With Major Depressive Disorder November 2008 March 2010
NCT04384965 Completed N/A Accelerated iTBS for Depressed Patients During the COVID-19 Pandemic May 12, 2020 November 1, 2022
NCT05138653 Completed Phase 1 A Single and Multiple Ascending Dose Trial of CVL-354 in Healthy Participants October 18, 2021 January 23, 2023
NCT01942785 Completed Phase 3 Study of Brexpiprazole as Adjunctive Treatment of Irritability in Patients With Major Depressive Disorder and an Inadequate Response to Antidepressant Therapy October 2013
NCT05271357 Completed N/A Transcranial Magnetic Stimulation for Depression in Autism Spectrum Conditions November 24, 2021 February 23, 2023
NCT00245557 Completed N/A Magnetic Resonance Imaging Study of Geriatric Depression November 2004 August 2008
NCT03067506 Completed Cognitive and Mood Assessment Data in Major Depressive Disorder Using Digital Wearable Technology March 1, 2017 July 3, 2017
NCT02150681 Completed Phase 1 Mindfulness-Based Cognitive Therapy for Perinatal Women With Mood Disorders October 2012 October 2013
NCT00104611 Completed Phase 3 Study of a Repetitive Transcranial Magnetic Stimulation (rTMS) Device for the Treatment of Major Depressive Disorder January 2004 November 2005
NCT05108701 Completed N/A Individual MBCT vs. CBT in Major Depression: A Pilot Study. November 2, 2015 January 15, 2018
NCT03624621 Completed N/A Integral Remediation for Major Depression ("Rehabilitación Integral Para la Depresión Mayor", RIDEM) March 15, 2018 December 31, 2020
NCT01263730 Completed N/A Tai Chi Training for Treating Depressed Chinese Americans February 2008 August 2010
NCT02579928 Completed Phase 4 Ketamine Infusion for Adolescent Depression and Anxiety October 2015 September 2019
NCT03363919 Completed N/A Biomarkers in Repetitive Transcranial Magnetic Stimulation (rTMS) for Adolescent Depression September 24, 2018 March 3, 2023
NCT02180607 Completed Neuronal Responses to Social Feedback in Major Depressive Disorder October 2013 October 2014
NCT04770285 Completed Phase 3 Trial to Evaluate the Effectiveness of a Digital Therapeutics in Adults Diagnosed With Major Depressive Disorder February 25, 2021 October 26, 2022
NCT00973934 Completed Phase 2 Magnetic Seizure Therapy (MST) for the Treatment of Major Depression April 2002 December 2009
NCT00526383 Completed N/A Do Antidepressants Induce Metabolic Syndromes METADAP Study November 2007 April 2013
NCT00705003 Completed Phase 2 Efficacy and Safety Study of a Combination Product [Drug:BCI-024 (Buspirone) and Drug:BCI-049 (Melatonin)] to Treat Major Depressive Disorder (MDD) May 2008 December 2008
NCT02838043 Completed Phase 3 The Efficacy, Safety, and Tolerability of Probiotics on the Mood and Cognition of Depressed Patients August 2016 May 2018
NCT03959735 Completed N/A High Intensity Interval Training in Severe Mental Illness October 10, 2019 August 30, 2021
NCT04009135 Completed N/A The Internet Therapy for Depression Trial June 10, 2019 July 1, 2021
NCT00149825 Completed Phase 2 Combining Antidepressant Medication and Psychotherapy for Insomnia to Improve Depression Outcome June 2004 August 2007
NCT01134731 Completed Phase 4 Paliperidone and Lithium in the Treatment of Suicidality - Treatment Indication and Epigenetic Regulation May 2010 February 2014
NCT00517985 Completed Phase 4 Duloxetine for Perimenopausal Depression February 2007 June 2008
NCT01114477 Completed NeuroStar TMS Therapy System: Utilization and Outcomes March 2010 September 2012
NCT00723970 Completed Phase 4 Quetiapine Extended Release (XR) for the Treatment of Menopausal Depression June 2007 May 2009
NCT01234558 Completed Phase 2 Single IV Dose of GLYX-13 in Patients With Treatment-Resistant Depression May 2011 July 2012
NCT04657575 Completed N/A Optimisation of ECT Based on ASTI vs Narcotrend March 1, 2021 February 28, 2023
NCT00744406 Completed Phase 2 Patient Dimensions as Predictors of Varied Treatment Responses and Outcomes in Patients With Major Depression July 2003
NCT00775203 Completed Phase 3 A Randomized, Double-blind, Two-arm Study Comparing the Efficacy and Safety of Trazodone Contramid® OAD and Placebo in the Treatment of Unipolar Major Depressive Disorder. June 2007 November 2007
NCT02525978 Completed N/A Heart Rate Variability in Depression July 2015 April 12, 2017
NCT05117632 Completed Phase 2 ALTO-100 in MDD and/or PTSD December 20, 2021 December 9, 2022
NCT04607226 Completed N/A Effects of Respiratory-Gated Transcutaneous Vagal Nerve Stimulation in Major Depression (Phase 1) November 2, 2020 October 12, 2022
NCT00759122 Completed Phase 4 Electroencephalography (EEG) Biomarkers of Response in Depression November 2002 December 2005
NCT02459236 Completed Phase 2 A Study of Intermittent Doses of CERC-301 in MDD June 2015 December 2016
NCT01436162 Completed Phase 3 Efficacy and Safety Study of SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder October 19, 2011 December 10, 2013
NCT01725282 Completed Phase 2 Study to Evaluate the Effect and Safety of Quetiapine Extended Release (XR) (FK949E) in Major Depressive Disorder December 14, 2011 August 24, 2013
NCT02149810 Completed N/A Automatic Self Transcending Meditation Versus Treatment as Usual May 2014 January 2017
NCT03163940 Completed N/A Laughter Yoga Intervention for People With Major Depressive Disorder June 1, 2017 August 1, 2018
NCT02078817 Completed Phase 2 Ketamine in Adolescents With Treatment-Resistant Depression September 2014 March 2018
NCT01149889 Completed Phase 2/Phase 3 Transcranial Direct Current Stimulation to Treat Major Depressive Disorder June 2010 December 2011
NCT01109030 Completed Phase 2/Phase 3 Pioglitazone as an Adjunct for Moderate to Severe Depressive Disorder April 2010 October 2011
NCT03835715 Completed Phase 4 Study With Vortioxetine on Emotional Functioning in Patients With Depression February 5, 2019 February 21, 2020
NCT02616549 Completed Phase 2 Multicomponent Yoga Intervention for Major Depressive Disorder October 2014 December 2015
NCT00168376 Completed N/A A Randomised Double-Blind Trial of Targeted Repetitive Transcranial Magnetic Stimulation in Major Depressive Disorder July 2004 April 2006
NCT01812291 Completed N/A Evaluation of a Stepped Care Approach to Manage Depression in Diabetes February 2012 November 2015
NCT00523081 Completed Phase 3 Study of Adolescence and Depression October 2006 January 2014
NCT00229398 Completed Medical and Psychiatric Co-Morbidity Among Treatment Resistant Patients With Major Depression Disorder November 1998 December 2004
NCT02389816 Completed Phase 3 A Phase 3 Study of Lu AA21004 in Patients With Major Depressive Disorder April 10, 2015 March 16, 2018
NCT01431001 Completed N/A Pilot Study in Multi-Coil Repetitive Transcranial Magnetic Stimulation (rTMS) for Treatment Resistant Depression October 2011 October 2013
NCT01995422 Completed N/A Effect of Physical Activity on Depressive Symptoms With a 5 Month Follow-up December 2011 June 2014
NCT02715778 Completed Translational Investigation of Gestational Environment on Neurobehavioral Function in Children February 2016 June 2019
NCT01443208 Completed Phase 1 Pharmacokinetics and Safety of Desvenlafaxine in Korean Healthy Subjects Following Single and Multiple Oral Doses of Desvenlafaxine Succinate Sustained Release Tablet November 2011 December 2011
NCT04345471 Completed Phase 3 A Study of MD-120 in Patients With Depression May 18, 2020 September 14, 2022
NCT00208897 Completed N/A Does Fluoxetine Have an Effect on the CNS CRF Systems in Women Abused in Childhood? December 1997 November 2007
NCT02082392 Completed Phase 4 Developing New Clinical Management Strategies September 2012 August 4, 2015
NCT03965858 Completed Phase 2 Efficacy, Safety and Pharmacokinetic Study of Inhaled Esketamine in Treatment-resistant Depression February 25, 2019 April 24, 2020
NCT03275766 Completed N/A Transcranial Magnetic Stimulation (TMS) for Motor Symptoms in Psychiatric Disorders June 1, 2016 July 15, 2019
NCT01851967 Completed N/A Effectiveness and Acceptability of MoodGYM in Treating Depressive Symptoms in Chinese Americans September 2014 November 2016
NCT03766867 Completed Phase 2 Vortioxetine Intravenous Infusion at Initiation of Oral Treatment With Vortioxetine in Patients With Depression December 3, 2018 August 28, 2019
NCT01152554 Completed Phase 3 A Study to Assess the Long- Term Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder June 2010 February 2012
NCT01342380 Completed Pioglitazone and Quetiapine XR Pharmacogenetic Study February 2011 May 2015
NCT02830399 Completed N/A Clinical Trial on Efficacy of rTMS to Improve ECT in Treatment-Resistant Depression July 15, 2016 July 12, 2019
NCT03031665 Completed Sex, Hormones and Gamma-Aminobutyric Acid (GABA) in Stress Induced Anhedonia in Depression October 1, 2017 June 15, 2022
NCT02502604 Completed N/A Cognitive Training Program for Individuals With Depression and Post-Traumatic Stress Disorder September 2015 August 2018
NCT00807248 Completed Phase 2 Short-term Study of Combination Treatment of Escitalopram and Gaboxadol in Major Depressive Disorder November 2008 February 2010
NCT04623034 Completed Phase 1 Evaluation of the Safety and Pharmacokinetics of MSI-195 to a Commercial S-Adenosylmethionine April 17, 2013 June 8, 2013
NCT03564067 Completed N/A MARt-Depression Trial July 5, 2018 September 3, 2021
NCT01447082 Completed General Practice Research Database Seroquel XR Safety Study October 2008 December 2012
NCT01427439 Completed A Prospective Epidemiological Research on Functioning Outcomes Related to Major Depressive Disorder February 2011
NCT02191124 Completed Phase 4 The Measurement-based Care in Patients With Depressive Disorder: A Randomized Controlled Trial June 2011 May 2013
NCT00072774 Completed Phase 3 Study Evaluating DVS-233 SR In Adult Outpatients With Major Depressive Disorder November 2004
NCT02508493 Completed Validation of the THINC-it Tool for Cognitive Dysfunction in Major Depressive Disorder November 2015 July 2016
NCT00610259 Completed Phase 2/Phase 3 Brief Behavioral Therapy for Insomnia (bBT-I) for Depressed Outpatients With Refractory Insomnia January 2008 August 2009
NCT00635219 Completed Phase 3 Randomised Placebo-controlled Duloxetine-referenced Efficacy and Safety Study of 2.5, 5 and 10 mg of Vortioxetine (Lu AA21004) in Acute Treatment of Major Depressive Disorder February 2008 April 2009
NCT01941043 Completed Phase 2 A Randomized, Double-Blind, Placebo-Controlled, Sequential Parallel Study of CERC-301 in the Adjunctive Treatment of Subjects With Severe Depression and Recent Active Suicidal Ideation Despite Antidepressant Treatment November 2013 October 2014
NCT01198795 Completed Phase 4 Safety Study of Escitalopram in Children 7 to 11 Years of Age With Major Depressive Disorder September 2010 April 2013
NCT01344733 Completed A Non Interventional Study to Investigating the Ratio of Mis-diagnosed Bipolar Symptoms in Patient With Major Depressive Disorder (MDD) May 2011 March 2012
NCT02644629 Completed Phase 4 Intra-nasal vs. Intra-venous Ketamine Administration April 2016 May 2020
NCT02256566 Completed N/A Cognitive Training for Mood and Anxiety Disorders September 2014 April 20, 2016
NCT04830215 Completed Phase 4 Brexpiprazole as Adjunctive Therapy in Adults With Major Depressive Disorder April 1, 2021 May 27, 2022
NCT01423253 Completed Phase 3 Major Depressive Disorder With Mixed Features - Extension September 2011 October 2013
NCT00581009 Completed Phase 1/Phase 2 The Role of Dopamine Metabolism in the Antidepressant Effects of Sleep Deprivation and Sertraline in Depressed Patients May 30, 2001 December 9, 2011
NCT01795326 Completed Physician Survey on Monitoring of Patients Treated With Quetiapine June 2013 September 2013
NCT00035048 Completed Phase 3 Treatment of Patients With Major Depressive Disorder With MK0869 (0869-068)(COMPLETED) November 21, 2001 December 31, 2003
NCT00596817 Completed Phase 3 Efficacy of Vortioxetine (Lu AA21004) in the Prevention of Relapse of Major Depressive Episodes December 2007 October 2009
NCT04903522 Completed N/A Can the Affects Conveyed by Baroque Music Reduce Anxiety in Patients With Major Depressive Disorder ? May 28, 2021 February 17, 2022
NCT03642522 Completed N/A Investigating Predictors of Treatment Response in Treatment-Resistant Depression (TRD) With Interleaved TMS/fMRI November 1, 2018 August 1, 2020
NCT01882452 Completed N/A A Randomised Controlled Clinical Trial of Memory Specificity Training (MEST) for Depression July 2013 October 2016
NCT00619619 Completed Phase 2 Study Evaluating Desvenlafaxine Succinate Sustained-Release (DVS SR) In The Treatment Of Child And Adolescent Outpatients With Major Depressive Disorder February 2008 November 2009
NCT00467402 Completed Phase 3 Efficacy, Safety and Tolerability of Agomelatine in the Prevention of Relapse of Major Depressive Disorder April 2007
NCT05041361 Completed N/A HypErthermia as an Additional Treatment for the Biology and Experience of Depression October 11, 2021 March 1, 2023
NCT00705185 Completed Exploring a Potential Blood Test to Diagnose Major Depressive Disorder April 2008 June 2010
NCT03685942 Completed N/A Efficacy of Light Therapy Device LUMINETTE® in Major Depressive Disorder January 16, 2019 September 8, 2023
NCT02423824 Completed Phase 3 Cognitive Dysfunction and Glucagon-like Peptide-1 Agonists May 2015 May 2016
NCT02816138 Completed Phase 4 Depressed Mood Improvement Through Nicotine Dosing (Depressed MIND Study) October 2016 September 12, 2017
NCT02132286 Completed Phase 4 Serotonin Transporter Genetic Variation and Amygdala Responses to Antidepressant Medications in Major Depression December 2008 April 2012
NCT03697603 Completed Phase 2/Phase 3 A Study of Brexpiprazole in Patients With Major Depressive Disorder July 30, 2018 July 4, 2022
NCT00555997 Completed Phase 2 A 12-Week, Placebo Controlled Trial of Ziprasidone as Monotherapy for Major Depressive Disorder March 2008 June 2010
NCT00025857 Completed Brain Function in Mentally Ill Adolescents October 22, 2001 June 29, 2012
NCT02418195 Completed Phase 2 miRNAs, Suicide, and Ketamine - Plasma Exosomal microRNAs as Novel Biomarkers for Suicidality and Treatment Outcome April 20, 2015 December 30, 2020
NCT03026036 Completed Neuroimaging Studies of Reward Processing in Depression April 2016 March 2021
NCT04181567 Completed Phase 4 Comparison of the Efficacy, Safety, and Relapse of ECT to ECT Plus Agomelatine for Depressed Patients March 3, 2014 November 22, 2019
NCT00489775 Completed Phase 3 Duloxetine Versus Paroxetine for Major Depression January 2004 June 2005
NCT02375308 Completed N/A Efficacy of Cognitive Behavioral to Hypnotherapeutic Treatment of Depression April 2015 June 28, 2018
NCT01934491 Completed N/A Cognitive Training for Depression II August 2013 May 16, 2017
NCT00278941 Completed Phase 3 Quetiapine Fumarate as Monotherapy in the Maintenance Treatment of Patients With Major Depressive Disorder December 2005 August 2007
NCT02752724 Completed N/A Ketamine Anesthesia for Improvement of Depression in ECT March 2016 April 30, 2018
NCT04364997 Completed Phase 3 Study of Desvenlafaxine in Treating Major Depressive Disorder. June 18, 2020 September 22, 2021
NCT00090649 Completed Phase 3 Study Evaluating DVS-233 SR And Venlafaxine ER In Adult Outpatients With Major Depressive Disorder March 2005
NCT00882362 Completed Phase 3 Long-Term Administration Study of Aripiprazole as an Adjunctive Therapy in Patients With Major Depressive Disorder March 2009 July 2012
NCT01717508 Completed N/A Neural Components Underlying the Treatment of Adolescent Depression October 2012 June 30, 2019
NCT02607514 Completed N/A Hyperthermic Yoga for Depressive Symptoms February 20, 2017 December 19, 2019
NCT05136365 Completed Phase 2 A Study of Xiongdan Wan Treating Depression December 28, 2021 August 30, 2022
NCT00073762 Completed Phase 3 Study Evaluating DVS-233 SR In Adult Outpatients With Major Depressive Disorder September 2004
NCT00518986 Completed Phase 4 Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Obstructive Sleep Apnea/Hypopnea and Depression October 2007 March 2009
NCT01369030 Completed Deplin® P.L.U.S. Program (Progress Through Learning Understanding & Support) November 2010 April 2012
NCT00048607 Completed Phase 3 Treatment of Patients With Major Depressive Disorder With MK0869 (0869-062)(COMPLETED) July 30, 2002 December 31, 2003
NCT00035009 Completed Phase 3 Treatment of Patients With Major Depressive Disorder With MK0869 (0869-059) September 20, 2001 March 24, 2004
NCT03121573 Completed N/A Efficacy and Safety of Duloxetine Among Individuals With Depressive Disorder in a 12 Weeks Trial December 15, 2014 January 17, 2017
NCT01203683 Completed Phase 3 Testing the Effectiveness of a Computer-based Program for Depression January 2011 October 2013
NCT00683592 Completed Phase 3 Randomized, Double-Blind, Placebo Controlled Study of Vilazodone's Efficacy, Safety, and Biomarkers of Response in Major Depressive Disorder (MDD) March 2008 March 2009
NCT03143634 Completed Phase 1/Phase 2 The Modular Protocol for Mental Health (MPMH) July 18, 2017 July 31, 2020
NCT00729755 Completed N/A Creatine Augmentation Treatment in Major Depressive Disorder Subjects August 2008 May 2012
NCT00105196 Completed Phase 3 A Study of Aripiprazole in Patients With Major Depressive Disorder March 2005 March 2008
NCT02615405 Completed N/A Phospholipid Hypothesis of Depression: From Molecular Biology, Neuroimaging to Behaviour August 2012 January 2015
NCT00034944 Completed Phase 3 Treatment of Patients With Major Depressive Disorder With MK0869 (0869-063) January 24, 2002 December 17, 2003
NCT05202119 Completed N/A Empower: tDCS for Major Depressive Disorder at Home May 1, 2022 August 31, 2023
NCT01266590 Completed Phase 1 A Study of LY2216684 and Digoxin in Healthy Subjects December 2010 February 2011
NCT01464229 Completed Phase 4 Iloperidone Augmentation of SSRIs for Patients With Major Depressive Disorder With Residual Anger and Irritability April 2012 December 2014
NCT04448431 Completed Phase 4 Comparison of Vortioxetine and Desvenlafaxine in Adult Patients Suffering From Depression June 18, 2020 February 4, 2022
NCT05431374 Completed Phase 3 Measurement-Based Care Vs. Standard Care for Major Depressive Disorder September 1, 2022 January 30, 2024
NCT02209597 Completed Phase 4 Clinical Study of Generic and Brand Bupropion in Depression June 25, 2014 August 14, 2016
NCT02634177 Completed N/A Genecept Assay™ vs. Treatment-as-Usual to Evaluate Efficacy of Assay-Guided Treatment in Adults With MDD January 2016 July 25, 2017
NCT04975100 Completed Phase 4 Evaluation of Efficacy and Safety of add-on Sarcosine in Patients With Major Depressive Disorder August 26, 2021 April 30, 2023
NCT00566202 Completed Phase 2 A Safety and Effectiveness Study of JNJ-18038683 in Patients With Moderate to Severe Depression December 2007 December 2008
NCT01537679 Completed N/A Meditation to Reduce Caregiver Stress March 2010 January 2012
NCT03738215 Completed Phase 3 Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD) Who Have Had an Inadequate Response to Antidepressants Alone November 9, 2018 September 30, 2021
NCT05120336 Completed N/A tVNS Effects on Motivation in Depression December 11, 2019 January 29, 2021
NCT03242213 Completed N/A Patient Management of Depression Through Technology: a Study of Digitally Enabled Engagement July 20, 2017 September 9, 2019
NCT04137367 Completed N/A A Personalized Approach to Effects of Affective Bias Modification on Symptom Change and Rumination November 19, 2019 April 3, 2022
NCT01312922 Completed Phase 3 Pipamperone/Citalopram (PNB01) Versus Citalopram (CIT) and Versus Pipamperone (PIP) in Major Depressive Disorder (MDD) September 2011 December 2012
NCT03795688 Completed The Role of Sex Steroids and Serotonin Brain Dynamics in Perinatal Mental Health January 24, 2019 December 1, 2020
NCT00849901 Completed Phase 3 A Study in the Treatment of Children and Adolescents With Major Depressive Disorder March 2009 October 2011
NCT06331572 Completed Exploring Blood Plasma Metabolomics: Unraveling the Metabolic Landscape in Treatment-Resistant Adolescent Depression August 1, 2021 December 20, 2023
NCT04711005 Completed Phase 1 Phase 1 Evaluation of (2R,6R)-Hydroxynorketamine January 11, 2021 May 31, 2023
NCT00320268 Completed Phase 3 Safety & Efficacy Study of Quetiapine Fumarate (SEROQUEL®) vs. Placebo in Major Depressive Disorder April 2006 May 2007
NCT01422213 Completed Phase 3 Efficacy Study of Vortioxetine on Cognitive Dysfunction in Adult Patients With Major Depressive Disorder December 2011
NCT03688139 Completed N/A Reward Function and Therapy for Late-Life Depression March 14, 2019 January 18, 2024
NCT03142919 Completed Phase 2 Lipopolysaccharide (LPS) Challenge in Depression September 7, 2017 December 1, 2020
NCT01323478 Completed Phase 3 Open-label Safety Extension Study of 15 and 20 mg of Vortioxetine (Lu AA21004) in Long-term Treatment of Major Depressive Disorder in Adults April 2011 October 2012
NCT00854100 Completed Phase 2 Safety and Efficacy of Cariprazine As Adjunctive Therapy In Major Depressive Disorder June 30, 2009 December 6, 2010
NCT00514865 Completed Phase 2 Placebo-Controlled Study of ONO-2333Ms in Patients With Recurrent Major Depressive Disorder June 13, 2007 June 2008
NCT01441258 Completed N/A Adaptation of Dialectical Behavior Therapy Skills-Groups for Individuals With Suicidal Ideation and Depression October 2011 February 2015
NCT01557946 Completed Phase 4 Glutamatergic and GABAergic Mediators of Antidepressant Response in Major Depression March 2012 September 2015
NCT02530164 Completed N/A Transcranial Direct Current Stimulation (tDCS) As Treatment for Major Depression September 2015 February 2021
NCT01371734 Completed Phase 3 A Study Of DVS SR In Treatment Of Children And Adolescent Outpatients With MDD August 2011 September 2015
NCT01189591 Completed N/A Slow-wave Sleep Deprivation in Depression June 2009 August 2011
NCT00608543 Completed Phase 4 Aripiprazole Augmentation of SSRI Therapy in Treatment Refractory Depression October 2005 January 2009
NCT01103271 Completed Phase 2 Pilot Study of Open-label Placebo to Treat Major Depressive Disorder May 2010 May 2011
NCT00108407 Completed N/A Study Comparing Two Types of Psychotherapy for Treating Depression and Substance Abuse October 2004
NCT03288714 Completed N/A Adaptive Design Study of NEST sTMS in Subjects With Major Depressive Disorder November 27, 2017 June 1, 2019
NCT01020799 Completed Phase 2 AZD7268 Safety and Tolerability Study November 2009 April 2010
NCT01696617 Completed Phase 4 Aripiprazole (Abilify®) as an Adjunctive Treatment for Inadequate Response in Major Depressive Disorder February 10, 2012 February 2019
NCT00353028 Completed Phase 4 Fluvoxamine Maleate in the Treatment of Depression/Depressive State : A Post-marketing Clinical Study in Children and Adolescents October 2006 July 2009
NCT02874131 Completed N/A Behavioral Activation + Cognitive Processing Therapy for PTSD and Comorbid MDD October 20, 2015 March 18, 2022
NCT00361374 Completed Phase 3 Safety and Effectiveness of Omega 3-Fatty Acids, EPA Versus DHA, for the Treatment of Major Depression July 2006 March 2013
NCT01325532 Completed N/A Efficacy and Safety of Cranial Electrical Stimulation (CES) for Major Depressive Disorder (MDD) November 2010 January 2015
NCT01424111 Completed Exploring Biomarkers for Depression August 2011 October 14, 2017
NCT04591301 Completed Phase 1 The Safety, Tolerability, and Pharmacokinetics Study of HEC113995 PA•H2O Tablets in Healthy Subjects July 4, 2019 December 6, 2019
NCT00402220 Completed N/A A Double-blind Sham Controlled Trial of rTMS in Treatment Resistant Major Depression March 2007 January 2011
NCT04091971 Completed Phase 4 Ketamine Treatment Effects on Synaptic Plasticity in Depression October 9, 2020 May 1, 2022
NCT05644093 Completed Phase 1 IM and IV SPL026 Drug Product in Healthy Participants January 3, 2023 April 5, 2023
NCT03658330 Completed Phase 2 Naltrexone Plus Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder May 2016 June 2018
NCT04826614 Completed N/A Comparing Efficacy of Optimal Treatment and Conventional Treatment for Major Depressive Disorder in Viet Nam March 1, 2021 July 30, 2023
NCT04322526 Completed Phase 4 Study of Naltrexone-Induced Blockade of Antidepressant Effects July 1, 2017 July 15, 2018
NCT04221230 Completed Phase 2 Study in Major Depressive Disorder With BTRX-335140 (NMRA-335140) vs Placebo December 14, 2019 June 8, 2022
NCT04543123 Completed Phase 4 Effect of Self-administered tDCS in Patients With MDD November 16, 2017 May 2, 2019
NCT03313674 Completed N/A Investigation of Seasonal Variations of Brain Structure and Connectivity in SAD November 1, 2017 October 5, 2019
NCT01409317 Completed Phase 2/Phase 3 Neural Predictors and Longitudinal Neural Correlates of Deep Transcranial Magnetic Stimulation for Treating Major Depression April 2013 January 2015
NCT00998569 Completed N/A Neurocognitive Enhancement in Major Depressive Disorder October 2009 March 2012
NCT00166114 Completed Phase 4 Depression, Epinephrine, and Platelet Function February 2002 January 2009
NCT02960763 Completed Phase 4 Optimizing Outcomes of Treatment-Resistant Depression in Older Adults February 24, 2017 September 1, 2021
NCT01990053 Completed N/A Pilot Study Assessing Computerized Cognitive Behavioral Therapy for Depression April 14, 2014 May 1, 2017
NCT02793258 Completed N/A Impact of tDCS on Emotional Processing in Major Depression July 22, 2016 December 2021
NCT01469377 Completed Phase 2 Safety and Efficacy of Cariprazine as an Adjunctive to Antidepressant Therapy in Major Depressive Disorder December 15, 2011 December 12, 2013
NCT03128021 Completed Phase 4 Neural Mechanisms of Monoaminergic Engagement in Late-life Depression Treatment Response (NEMO) May 24, 2017 August 30, 2023
NCT00811252 Completed Phase 3 Randomised Placebo-controlled Duloxetine-referenced Study of Efficacy and Safety of 5 mg of Vortioxetine (Lu AA21004) in Acute Treatment of Major Depressive Disorder in Elderly Patients January 2009 March 2010
NCT03672175 Completed Phase 3 A Study to Evaluate the Efficacy of SAGE-217 in the Treatment of Adult Participants With Major Depressive Disorder November 19, 2018 March 17, 2020
NCT01700829 Completed Phase 4 Ketamine in the Treatment of Suicidal Depression June 2012 July 31, 2017
NCT00209066 Completed Treatment of Reduced Heart Rate Variability Associated With Major Depression With Electroconvulsive Therapy November 1998 April 2005
NCT00191932 Completed Phase 4 Switching to Duloxetine From Other Antidepressants August 2004 March 2006
NCT01185977 Completed Phase 4 Biomarkers of Antidepressant Treatment in Adolescents With Major Depression (The Adolescents MDD Study) April 2010
NCT05615948 Completed Phase 4 Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression December 6, 2022 May 17, 2024
NCT01838681 Completed Phase 3 Brexpiprazole as Adjunctive Treatment in Patients With Major Depressive Disorder With an Inadequate Response to Antidepressant Treatment June 2013 June 2016
NCT02263248 Completed Phase 1/Phase 2 Incomplete Response in Late-Life Depression: Getting to Remission With Buprenorphine December 2014 May 1, 2018
NCT03421574 Completed N/A Trial of MR-guided Focused Ultrasound for Treatment of Refractory Major Depression January 19, 2018 July 28, 2021
NCT01999010 Completed N/A Mental Health Telemetry for Self-Management in Major Depression November 2014 April 2016
NCT01482221 Completed Phase 2 A Study to Assess the Effect and Safety of AZD6765 in Patients With Major Depressive Disorder December 16, 2011 August 26, 2013
NCT04634669 Completed Phase 2 Open-Label Safety Study of AXS-05 in Subjects With TRD (EVOLVE) September 23, 2020 March 4, 2022
NCT00234195 Completed Phase 4 Wellbutrin XL, Major Depressive Disorder and Breast Cancer September 2005 January 2007
NCT01263236 Completed Phase 1 A Study of LY2940094 in Major Depressive Disorder December 2010 September 2011
NCT02431806 Completed Phase 3 Safety and Efficacy of Levomilnacipran ER in Adolescent Participants With Major Depressive Disorder June 23, 2015 August 19, 2019
NCT03188185 Completed Phase 3 A Study of ALKS 5461 for Treatment Refractory Major Depressive Disorder (MDD) June 12, 2017 March 5, 2020
NCT01715805 Completed Phase 3 Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD) November 15, 2012 June 24, 2016
NCT01803802 Completed N/A Effects of Early Abuse on Adult Intimate Relationships April 2005 August 2014
NCT01305889 Completed N/A The Effect of Problem Solving Therapy and Antidepressant Therapy on Cerebral Perfusion and Brain Derived Neurotropic Factor (BDNF) in Depressed Elders March 2011 February 16, 2018
NCT04082806 Completed Phase 2 Memory Enhancement by Gamma-hydroxybutyrate vs. Trazodone in Major Depressive Disorder. August 6, 2020 April 6, 2022
NCT03302611 Completed N/A Trial of Surf and Hike Therapy for Major Depressive Disorder January 1, 2018 September 1, 2020
NCT03739632 Completed Phase 2 Study to Explore the Effective Doses and to Assess the Safety and Efficacy of Hypidone Hydrochloride Tablets November 30, 2018 December 23, 2019
NCT01468610 Completed N/A Neurocognition and Work Productivity in Major Depressive Disorder (MDD) January 2012 December 2014
NCT03555136 Completed Real-life Effectiveness of Vortioxetine in Depression November 17, 2017 January 31, 2021
NCT00919932 Completed N/A Using a Text-message System to Engage Depressed Adolescents in Cognitive-behavioral Therapy Homework February 2009 January 2010
NCT00179257 Completed Phase 3 The Effectiveness of Sertraline in Patients Who Have Had Inadequate Response to Escitalopram June 2004 March 2005
NCT03183505 Completed Phase 2 Comparison of Anyu Peibo With Placebo in Treatment of MDD，Ⅱb June 30, 2017 November 29, 2018
NCT01640483 Completed N/A Differential Efficacy of Supportive and Interpretative Psychodynamic Techniques for Dependent and Self-critical Depressive Patients December 2012 December 2015
NCT02453438 Completed Mood Patient Powered Research Network (MoodNetwork) March 2015 March 2019
NCT04593537 Completed Action Tendencies and Prognosis in Major Depressive Disorder June 1, 2020 June 1, 2021
NCT04619121 Completed N/A Near-infrared Radiation-transcranial Photobiomodulation for Major Depressive Disorder December 21, 2020 July 31, 2022
NCT03822065 Completed Phase 1 A Relative Bioavailability Food Effect Study of LY03005 January 16, 2019 February 16, 2019
NCT04536714 Completed N/A Efficacy of Pythagorean Self-Awareness Intervention for Major Depressive Disorder December 3, 2018 January 21, 2020
NCT04114565 Completed Prevalence of Major Depression Among Immigrants in Santiago, Chile July 29, 2019 June 30, 2020
NCT02332291 Completed Phase 4 Connectivity Affecting the Antidepressant REsponse Study April 2015 August 2020
NCT01541475 Completed Phase 4 Neuroimaging Study of Bupropion Treatment in Patients With Major Depressive Disorder March 2009 January 2011
NCT02013531 Completed Phase 3 Brexpiprazole (OPC-34712) as an Adjunctive Treatment in Adults With Major Depressive Disorder and Anxiety Symptoms November 2013 June 2014
NCT05419869 Completed Phase 2 Pilot Decentralized Trial June 1, 2022 January 26, 2023
NCT03822416 Completed Phase 2 Treating Smokers With Mental Illness March 1, 2019 May 4, 2020
NCT02548949 Completed Korean Post Marketing Surveillance to Observe Effectiveness and Safety of PRISTIQ April 25, 2016 February 12, 2020
NCT01971203 Completed N/A Efficacy of Extended-release Quetiapine (Seroquel XR) as Adjunctive Therapy to Cognitive Behavioral Therapy in the Treat September 2009 June 2013
NCT01380704 Completed Phase 1 Safety and Pharmacodynamic Study of ABT-436 in Major Depressive Disorder June 2011 September 2011
NCT01625845 Completed Phase 2 Anti-INFLammatory to Address Mood and Endothelial Dysfunction (INFLAMED) June 2012 May 2014
NCT02371980 Completed Phase 4 Vortioxetine, 5, 10, and 20 mg, Relapse Prevention Study in Adults With Major Depressive Disorder (MDD) February 10, 2015 April 25, 2019
NCT05516368 Completed N/A TF-CBT for Long-term PTSD, Major Depressive Disorder and Anxiety Disorders in Victims of Terrorism March 2012 January 2015
NCT04598607 Completed Phase 1 Tolerability and Pharmacokinetics of Hypidone Hydrochloride in Healthy Subjects October 30, 2020 January 15, 2021
NCT00735709 Completed Phase 3 Efficacy Study of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder August 2008 August 2009
NCT03779789 Completed Phase 4 Vortioxetine in the Elderly vs. Selective Serotonin Reuptake Inhibitors (SSRIs): a Pragmatic Assessment February 1, 2019 February 28, 2023
NCT03871088 Completed N/A N-3 Fatty Acids as the First-line Antidepressant Therapy: From Biomarkers to Clinical Subtypes July 2015 December 2018
NCT01890356 Completed N/A Maintenance Transcranial Electrical Stimulation for Depression June 2013 February 2018
NCT01876823 Completed Phase 2/Phase 3 Memantine Plus Es-citalopram in Elderly Depressed Patients With Cognitive Impairment April 2006 March 2010
NCT01432457 Completed Phase 4 Study Evaluating Desvenlafaxine Succinate Sustained-Release (DVS SR) in Adult Outpatients With Major Depressive Disorder (MDD) October 2011 August 2012
NCT00809770 Completed N/A Contingency Management of Psychostimulant Abuse in the Severely Mentally Ill April 2008 August 2013
NCT03821506 Completed N/A ROOM-LIGHT: Effect of a Dynamic Lighting System in Depressed Inpatients May 15, 2019 March 15, 2023
NCT04226963 Completed A Naturalistic Study of Ketamine for Treatment Resistant Mood Disorders December 4, 2019 July 4, 2022
NCT00985725 Completed Phase 2 SPD489 in Adults With Persistent Executive Function Impairments (EFI) and Partial or Full Remission of Recurrent Major Depressive Disorder October 29, 2009 April 18, 2011
NCT01828931 Completed N/A Lifestyle Intervention for Diabetes and Weight Management in Psychosis December 2012 November 2015
NCT04721678 Completed N/A Internet-administered Interpersonal Psychotherapy for Depressive Symptoms January 22, 2021 February 15, 2022
NCT01601210 Completed Early Phase 1 Dose-Ranging Trial of Creatine Augmentation for Adolescent Females With Treatment-Resistant Major Depressive Disorder June 2012 May 2014
NCT01608399 Completed N/A Clinical Trial of the Effectiveness of Metacognitive Therapy in the Treatment of Patients With Major Depressive Disorder March 2012 June 2016
NCT06232291 Completed Observation of Safety and Tolerability Within 1 Year of the Use of R-ketamine / Placebo in Drug-resistant Depression April 21, 2023 May 24, 2024
NCT02181231 Completed Phase 1/Phase 2 Buprenorphine Used With Treatment Resistant Depression in Older Adults June 1, 2016 April 30, 2018
NCT01514435 Completed N/A Changes in Cerebral Glucose Metabolism After Electroconvulsive Therapy (ECT) May 2006 July 2011
NCT00985504 Completed Phase 4 A Study of Patients With Major Depressive Disorder and Residual Apathy September 2009 December 2010
NCT02004145 Completed N/A Trial of a Positive Psychology Intervention in Major Depressive Disorder October 2013 September 2015
NCT00883519 Completed Phase 1/Phase 2 The Efficacy of Parent Involvement in the Treatment of Adolescent Depression January 2009 December 2010
NCT05181527 Completed Phase 4 Repurposing of Dextromethorphan as an Adjunct Therapy in Patients With Major Depressive Disorder February 10, 2022 November 30, 2023
NCT02657980 Completed Phase 3 The Effect of tDCS in Patients With Moderate to Severe Major Depressive Disorder April 2015 December 2016
NCT01148979 Completed Phase 4 Lisdexamfetamine Dimesylate in Residual Symptoms and Cognitive Impairment in Major Depressive Disorder. September 2010 October 2014
NCT03645096 Completed Phase 1 Development of Pregnenolone as a Treatment for Depression September 1, 2019 May 31, 2022
NCT04295941 Completed Long-term Study With Trazodone Once-a-Day June 23, 2020 November 16, 2021
NCT03435744 Completed Phase 3 Simvastatin as an Augmentation Treatment for Treatment Resistant Depression: Randomized Controlled Trial. January 1, 2019 June 30, 2021
NCT00822744 Completed Phase 2 An Eight-week Study of SSR411298 as Treatment for Major Depressive Disorder in Elderly Patients December 2008 February 2010
NCT05950061 Completed Phase 3 Sertraline Versus Escitalopram in South Asian Participants With Moderate to Severe Major Depressive Disorder June 1, 2022 February 26, 2023
NCT02153281 Completed N/A Neuroimaging MAO-B in Medication Free TR-MDD Using Novel Tracer June 2014 May 2019
NCT01052077 Completed Phase 2 Study of the Safety and Efficacy of OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder March 2010 November 2011
NCT06372210 Completed N/A A Trial to Assess a Wearable Patch's Functioning to Detect Medication Ingestion June 26, 2023 July 19, 2023
NCT03726658 Completed Phase 1/Phase 2 AGN-241751 in the Treatment of Major Depressive Disorder November 8, 2018 October 23, 2019
NCT00672620 Completed Phase 3 Efficacy and Safety of Vortioxetine (Lu AA21004) in the Treatment of Patients With Major Depressive Disorder April 2008 December 2008
NCT01357083 Completed The Study of Serum Melatonin Rhythm Levels in Patients With Major Depressive Disorder August 2010 October 2010
NCT03733574 Completed Phase 1 A Study of LY03005 vs Pristiq June 19, 2018 July 26, 2018
NCT02907476 Completed N/A The Treatment of Depression With Yoga and Walking January 4, 2017 August 2, 2019
NCT01101373 Completed Treatment of Severe Depressive Illness by Targeted Brain Surgery October 2000 April 2010
NCT00781742 Completed Phase 2 AZD6765 Severe Major Depressive Disorder (MDD) IV October 2008 March 2010
NCT05388539 Completed N/A TBS Treatment for Treatment-Resistant Depression June 6, 2022 April 1, 2024
NCT00404755 Completed Phase 4 Dichotic Listening as a Predictor of Medication Response in Depression July 2006 August 2011
NCT01473394 Completed Phase 4 Safety, Efficacy, and Tolerability of Vilazodone in Major Depressive Disorder December 2011 February 2013
NCT03514810 Completed Phase 1 Combined Sertraline and Ketoprofen Administration in Major Depressive Disorder January 10, 2017 December 31, 2017
NCT01538199 Completed N/A Transcranial Laser Therapy for Major Depressive Disorder February 2012 August 2015
NCT01377194 Completed Phase 3 Safety and Efficacy of Levomilnacipran ER (Levomilnacipran SR) in Major Depressive Disorder June 2011 March 2012
NCT04244253 Completed Phase 2 A Phase 2 Trial of OPC-64005 for Major Depressive Disorder March 3, 2020 February 25, 2022
NCT01426997 Completed Phenotype Depression Study July 2010 May 2016
NCT00125957 Completed Phase 3 The Effects of Wellbutrin (Bupropion) on Residual and Cognitive Symptoms in SSRI-treated Depression August 2005 December 2011
NCT01022632 Completed N/A Effect of Curcumin as Nutraceutical in Patients of Depression March 2009 January 2010
NCT02141776 Completed Phase 4 Comparison of Anodal Transcranial Direct Current Stimulation (t-DCS) and Sham Stimulation in Patients With Treatment-resistant Depression May 2014 January 8, 2018
NCT00421369 Completed N/A Augmentation of the Antidepressant Action of Sertraline With Triiodothyronine (T3)and Reboxetine: Clinical Efficacy, Adverse Effects and Predictors of Response. September 2007 August 2011
NCT04604210 Completed Phase 2 Symptom-specific TMS Targets for Depression and Anxiety February 3, 2021 December 28, 2023
NCT00570050 Completed Phase 3 Effect of Intranasal Insulin on Depressive Symptoms in Major Depressive Disorder June 2013 September 2014
NCT00696293 Completed Phase 4 Duloxetine Treatment of Major Depression and Chronic Low Back Pain For Older Adults May 2007 April 2010
NCT00592384 Completed Phase 4 Project to Improve Symptoms and Mood in People With Spinal Cord Injury July 2007 September 2012
NCT00933439 Completed N/A Assessment of Cognitive Functioning Before and After Treatment With Duloxetine February 2005 September 2007
NCT02058693 Completed Phase 4 Adjunctive Mixed Salts Amphetamine for Depressed Adults With Incomplete Response to Current Antidepressant Therapy December 2010 December 2014
NCT02134808 Completed Phase 4 Creatine Augmentation for Adolescent Females With Treatment-Resistant Major Depressive Disorder November 21, 2014 June 27, 2017
NCT00787501 Completed Phase 1 Imaging Antidepressant vs. Cognitive Behavior Therapy Effects on Unipolar Depression June 2008 July 2011
NCT02466958 Completed Phase 4 Trial of Levomilnacipran in Geriatric Depression June 2016 December 9, 2018
NCT03737474 Completed Phase 3 A Long-Term Study of Brexpiprazole in Patients With Major Depressive Disorder October 4, 2018 April 13, 2021
NCT01725048 Completed Early Phase 1 Pilot Study to Evaluate Individualized Choice of Antidepressants in Patients With Cancer January 2011 October 2013
NCT00414323 Completed Phase 1 Evaluation of the Effects of Duloxetine on Norepinephrine November 2006 May 2007
NCT00369798 Completed Phase 1 Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed Patients August 2, 2006 October 12, 2016
NCT00599911 Completed Phase 2 Dose-finding Study With Lu AA24530 in Major Depressive Disorder October 2007 April 2009
NCT05666687 Completed Phase 1 An Open-label, Adaptive Design, Positron Emission Tomography Study in Healthy Male Participants to Characterize Receptor Occupancy by MIJ821 in the Brain January 11, 2023 November 7, 2023
NCT04939818 Completed Clinical Feasibility of Speech Phenotyping for Remote Assessment of Neurodegenerative and Psychiatric Disorders June 14, 2021 September 15, 2022
NCT01309776 Completed Phase 4 Comparison of Tianeptine Versus Escitalopram Patients Major Depressive Disorder March 2011 September 2012
NCT00969709 Completed Phase 3 Safety and Efficacy of Levomilnacipran ER (F2695 SR) in Major Depressive Disorder September 2009
NCT01734291 Completed N/A Brief Multifamily Psychoeducation for Families of Patients With Chronic Major Depression October 1, 2012 October 9, 2016
NCT01896934 Completed Phase 4 Frontal Hypoperfusion Effects on Antidepressant Outcomes in Late-Life Depression July 2013 June 2016
NCT02553915 Completed Phase 2/Phase 3 Omega-3 Fatty Acids for Major Depressive Disorder With High Inflammation: A Personalized Approach December 2015 March 31, 2022
NCT00351169 Completed Phase 3 Efficacy of Seroquel SR in Combination With an Antidepressant in Treatment of Major Depressive Disorder May 2006 June 2007
NCT05384041 Completed N/A Cranial Electrotherapy Stimulation for the Treatment of Major Depressive Disorder in Adults April 28, 2022 October 24, 2022
NCT05271084 Completed Phase 1/Phase 2 Pentoxifylline as an Adjunct to Citalopram in Adult Patients With Major Depressive Disorder November 10, 2021 June 8, 2022
NCT02176408 Completed N/A Efficacy of Adjunctive Exercise for the Behavioral Treatment of Major Depression June 2014 August 2016
NCT00824044 Completed Phase 4 Quantitative Electroencephalogram (QEEG) Predictors of Response to Psychotherapy Versus Antidepressant Treatment in Depression July 2008 March 2011
NCT01608295 Completed Phase 4 Vilazodone for Treatment of Geriatric Depression July 2012 September 2015
NCT04824157 Completed Ketamine IV Classic Protocol : Five Years Follow up August 8, 2019 March 30, 2020
NCT04785456 Completed N/A rTMS for Suicidality in Opioid Use Disorder March 1, 2022 March 1, 2024
NCT00548964 Completed Phase 1 Continuation Ketamine in Major Depression October 2007 July 2013
NCT02922556 Completed N/A Piloting a Novel, Mobile Cognitive Training Tool for Patients With Major Depressive Disorder (MDD) September 2015 June 21, 2019
NCT02749721 Completed Phase 4 The Relationship Among Changes in Brain Network Activation in Adult Outpatients With Major Depressive Disorder December 2016 January 31, 2019
NCT01719315 Completed Neurophysiologic Correlates of Hypersomnia November 2012 June 2018
NCT02579343 Completed N/A Adjunctive Treatment of Major Depression Utilizing Auricular Acupuncture August 2015 May 2016
NCT04874077 Completed Using Voice Biomarkers to Predict the Likelihood of Major Depressive Disorder April 21, 2021 September 4, 2021
NCT01110889 Completed Phase 3 Efficacy, Safety and Tolerability of Agomelatine Sublingual Tablets in the Treatment of Major Depressive Disorder May 2010
NCT00593879 Completed Phase 2 Flexible Dose Titration Add-on Study to Treat Major Depressive Disorder February 2005 August 2006
NCT02461927 Completed Phase 1/Phase 2 Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder January 1, 2015 October 30, 2023
NCT05065580 Completed N/A OMT as an Adjunctive Treatment in MDD March 12, 2021 March 23, 2023
NCT00529789 Completed Phase 2 Open-Label Study of Duloxetine in the Treatment of Children and Adolescents With Major Depressive Disorder August 2007 September 2008
NCT01606384 Completed Phase 2 Evaluation of the Potential Effects of SSR149415 on the Hypothalamic-pituitary-adrenal Axis in Outpatients With Major Depressive Disorder December 2006 August 2007
NCT00188396 Completed N/A Effect of the Menstrual Cycle on the Symptoms of Depression and Treatment Response April 2004 October 2008
NCT00223197 Completed Phase 4 Pregnenolone Trial for Depression in Bipolar Disorders or Recurrent Major Depressive Disorder With Substance Abuse February 2004 April 2006
NCT00305045 Completed N/A Treating Refractory Major Depressive Disorder With Repetitive Transcranial Magnetic Stimulation March 2005 May 2009
NCT01392287 Completed Phase 1 Treatment Resistant Geriatric Depression in Primary Care May 2010 April 2012
NCT00519428 Completed Phase 4 Does Dual Therapy Hasten Antidepressant Response? August 2007 March 2012
NCT01304147 Completed N/A Intranasal Ketamine in Treatment-Resistant Depression October 2011 October 2014
NCT00107120 Completed Phase 3 The Safety and Efficacy of Escitalopram in Pediatric Patients With Major Depressive Disorder March 2005
NCT00770289 Completed Study Comparing Remission Rates, in Patients With Major Depressive Disorder (MDD) May 2008 December 2009
NCT01318434 Completed Phase 2/Phase 3 A Paroxetine- and Placebo-Controlled Study of 50 mg/Day and 100 mg/Day of EB-1010 Among Outpatients With Major Depressive Disorder Who Have Responded Inadequately to Prior Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs) February 2011 February 2013
NCT01526395 Completed N/A Decreasing the Use of Unmodified Electroconvulsive Therapy (ECT) in an Indian Hospital August 2011 April 2012
NCT02400736 Completed N/A Supported Employment in Patient Aligned Care Teams August 3, 2015 September 30, 2020
NCT04014959 Completed N/A Mini Theta Burst TMS in MDD Patients July 14, 2017 June 30, 2021
NCT01710202 Completed Sensitivity of Short and Long Allele Carriers of the 5-HTTLPR to Environmental Threat Post Hydrocortisone Administration October 2012 November 2014
NCT00205946 Completed Phase 1 The Effects of Acute Administration of Bupropion on Neural Substrates Underlying Hedonic Capacity April 2005 July 2007
NCT02612142 Completed N/A Physical EXercise as an Adjunct Treatment for Depression June 2011 July 2015
NCT04841798 Completed N/A MAO-B Occupancy in Depressed Patients April 15, 2021 July 3, 2023
NCT02272517 Completed Phase 3 Efficacy of Vortioxetine Versus Escitalopram on Cognitive Function in Patients With Inadequate Response to Current Antidepressant Treatment of Major Depressive Disorder December 2014 March 2016
NCT01380691 Completed Phase 1 A Study of LY2216684 in Healthy Participants June 2011 September 2011
NCT03551288 Completed Phase 1 Effect of Food, Gender, and Age on the Pharmacokinetic Profile of SUVN-911 in Healthy Subjects May 22, 2018 July 16, 2018
NCT00812227 Completed N/A Neural Correlates of Psychodynamic Psychotherapy for Depression August 2008 February 2013
NCT02843373 Completed Brain-Based Biomarkers in Response to TMS in MDD March 2016 December 2019
NCT01667926 Completed N/A Ketamine Versus Placebo for Treatment Resistant Major Depressive Disorder January 2013 November 2015
NCT00049972 Completed Phase 4 Major Depressive Disorder Study In Adults September 2002 September 2003
NCT03554447 Completed N/A Role of Pentoxifylline as an Adjuvant Therapy for Adult Patients With Major Depressive Disorder April 20, 2015 December 31, 2018
NCT00807105 Completed Phase 2 Evaluation of the H-coil Transcranial Magnetic Stimulation TMS Device - Safety and Feasibility Study for Acute and Maintenance Treatment in Major Depressive Episode June 2008 May 2010
NCT00035295 Completed Phase 3 Treatment of Patients With Major Depressive Disorder With MK0869 (0869-061) November 8, 2001 December 5, 2003
NCT03404466 Completed Phase 1/Phase 2 To Explore the Safety and Efficacy of Hypidone Hydrochloride Tablets in Treatment of Patients With MDD February 24, 2018 July 17, 2018
NCT00290914 Completed Phase 2 Safety and Efficacy Study of Vilazodone and Discovering Genetic Markers Associated With Response in Patients With Major Depressive Disorder
NCT02046564 Completed Phase 3 Assess the Efficacy and Safety of ASC-01 in Patients With Major Depressive Disorder February 2014 September 2016
NCT01001559 Completed Combination Deplin® and Antidepressant Therapy for a Major Depressive Episode (MDE)- a Retrospective Analysis August 2009 June 2011
NCT01034462 Completed Phase 3 Safety and Efficacy of Levomilnacipran ER (F2695 SR) in Major Depressive Disorder December 2009 December 2011
NCT03922581 Completed N/A Primary-Care Based Mindfulness Intervention September 14, 2018 August 18, 2023
NCT01655706 Completed Phase 3 Canadian Biomarker Integration Network for Depression Study April 23, 2012 January 2017
NCT00252330 Completed Phase 3 Efficacy and Safety of SR58611A in Patients With Major Depressive Disorder September 2005 January 2007
NCT00411099 Completed Phase 3 Efficacy, Safety and Tolerability of Agomelatine in the Treatment of Major Depressive Disorder December 2006
NCT01483391 Completed N/A Early Intervention for Youth at Risk for Bipolar Disorder October 6, 2011 September 15, 2020
NCT02935647 Completed Phase 1 Burst Suppression Anesthesia for Treatment of Severe Depression October 1, 2016 September 2018
NCT03932825 Completed Phase 2 Nitrous Oxide for Major Depressive Disorder April 1, 2019 March 31, 2021
NCT01436149 Completed Phase 3 Efficacy and Safety Study of SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder October 27, 2011 December 23, 2013
NCT01701141 Completed Depression and Dopamine Transporter Function Study Using C-11 Altropane January 2012 July 2014
NCT04342299 Completed The Antidepressant Advisor (Study 3): fMRI Study to Predict Treatment Response in Patients With Depression August 1, 2018 November 18, 2021
NCT02427789 Completed N/A Therapeutic Effectiveness of Exercise Associated to the Pharmacotherapy in Major Depression March 2012 July 2014
NCT00788918 Completed N/A Study of Cerebral Function in Patients With Chronic Hepatitis C Infection (HCV/CNS) November 2008 November 2012
NCT01437657 Completed Phase 2 MARIGOLD Study: A Study of RO4917523 Versus Placebo as Adjunctive Therapy in Patients With Major Depressive Disorder and an Inadequate Response to Ongoing Antidepressant Therapy October 2011 September 2013
NCT00463242 Completed Phase 3 A Placebo- and Paroxetine-controlled Study of the Efficacy, Safety and Tolerability of Agomelatine (25 or 50 mg) in the Treatment of Major Depressive Disorder (MDD) March 2007
NCT05355285 Completed N/A Type 1 Diabetes and Depression: Role of Brain Glutamate January 2011 November 2014
NCT01831882 Completed Identifying Biological Markers for Severe Depression July 2013 August 2020
NCT01670279 Completed Phase 1 Phase 1 Study to Assess the Safety/Tolerability of Brexpiprazole as Adjunctive Therapy in Elderly Subjects With Major Depressive Disorder July 2012 May 2013
NCT03433339 Completed Phase 1/Phase 2 Spinal Cord Stimulation for the Treatment of Major Depressive Disorder August 29, 2018 September 13, 2022
NCT00531622 Completed Phase 3 An Eight-week Study of Saredutant and Escitalopram as Combination Treatment for Major Depressive Disorder September 2007 January 2009
NCT01197508 Completed Phase 3 A Study to Assess the Efficacy and Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder. September 2010 January 2012
NCT00361218 Completed Phase 3 Biological Markers of Response to Treatment in Major Depressive Disorder October 2005 December 2008
NCT02855580 Completed Integrating Pharmacogenomic Testing Into a Child Psychiatry Clinic September 2016 July 6, 2017
NCT00109044 Completed Phase 3 Comparison of Escitalopram Combination in Adult Patients With Major Depressive Disorder March 2005 May 2006
NCT02800226 Completed Phase 3 Pilot Study Comparing 10hz vs Theta Burst Stimulation March 2014 May 2015
NCT01447576 Completed Phase 2 Study of Safety & Tolerability of OPC-34712 as Adjunctive Therapy in Treatment of Adult Patients With Major Depressive Disorder September 2009 December 2012
NCT06003361 Completed N/A Rise Study for Depression August 31, 2023 December 21, 2023
NCT00385307 Completed Phase 3 Efficacy and Safety of SR58611A in Patients With Major Depressive Disorder (SIRIUS) September 2006 November 2007
NCT00146523 Completed Phase 3 An International Study of the Safety and Tolerability of Corlux for Psychotic Symptoms in Psychotic Major Depression May 2005 July 2006
NCT05195203 Completed Phase 1 A Study of HS-10353 in Chinese Participants. January 27, 2021 March 31, 2023
NCT05528718 Completed SMILE Trial - Imaging Sub-Study March 7, 2023 June 14, 2024
NCT01557712 Completed Phase 3 Estimate the Efficiency of the Association of an Injection of Ketamine and the Venlafaxine in the Severe Major Depressive Disorder for Six Weeks March 2012 January 2017
NCT00296920 Completed Phase 3 Deep Brain Stimulation for Refractory Major Depression June 2002
NCT00360256 Completed Genetic Study of Liver Enzymes in Patients With Side Effects From Antidepressants June 2006 December 2007
NCT01430767 Completed Measuring Adherence to Medication for Depression and Attention-deficit Hyperactivity Disorder September 2011 December 2014
NCT02184221 Completed N/A Deep-brain Magnetic Stimulation (DMS) in the Treatment of Major Depressive Disorder May 2010 April 2011
NCT00816322 Completed N/A The Effect of Fish Oil in Major Depressive Disorder January 2005 December 2014
NCT00059579 Completed Brain Regulation of Emotions in People With Depression and Anhedonia April 24, 2003 November 12, 2010
NCT00683852 Completed Phase 3 A Double-Blind, Placebo-Controlled Study of Aripiprazole Adjunctive to Antidepressant Therapy September 2008 September 2009
NCT03994081 Completed N/A Mechanism of Action of tACS for the Treatment of MDD June 9, 2021 June 2, 2023
NCT00707980 Completed Phase 3 Safety and Tolerability of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder June 2008 August 2010
NCT00873795 Completed N/A Compare the Efficacy and Tolerability of the Combination of Aripiprazole and Selective Serotonin Reuptake Inhibitors (SSRIs) Used in Major Depression April 2007 March 2009
NCT01533285 Completed Early Phase 1 Exploratory Study on the Mood and Cytokine Levels in Female Healthy Participants and Major Depressive Disorder Patients May 2012 November 2013
NCT01594866 Completed Phase 4 Lexapro®'s Efficacy After Dose Escalation in Remission Study May 2012 December 2016
NCT01244854 Completed N/A Life Goals Behavioral Change to Improve Outcomes for Veterans With Serious Mental Illness October 1, 2010 March 6, 2015
NCT02385786 Completed N/A Mindfulness-Based Cognitive Therapy Effect on Depression and C-Reactive Protein Levels After 8 Weeks of Treatment November 2011 August 2012
NCT01473381 Completed Phase 4 Safety and Efficacy of Vilazodone in Major Depressive Disorder December 2011 June 2013
NCT01973283 Completed Phase 4 Antidepressant Response in the Treatment of Depressive Symptoms and Frailty Characteristics in Older Adults February 19, 2014 December 5, 2020
NCT03556124 Completed N/A Transcranial Direct Current Stimulation in Major Depression February 2, 2018 May 31, 2020
NCT00135421 Completed Phase 1/Phase 2 Study of BMS-562086 in the Treatment of Outpatients With Major Depressive Disorder November 2005 October 2007
NCT00953745 Completed N/A Dopaminergic Effects of Adjunctive Aripiprazole on the Brain in Treatment-Resistant Depression May 2009 December 2012
NCT00321490 Completed Phase 3 Safety & Efficacy Study of Quetiapine Fumarate (SEROQUEL®) vs. Placebo and Active Control in Major Depressive Disorder April 2006 May 2007
NCT01157078 Completed Phase 3 A Study to Assess the Efficacy and Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder (MDD) June 2010 November 2011
NCT03977038 Completed Investigation of the Effects of Repetitive Transcranial Magnetic Stimulation on Cognition in Depression May 30, 2020 June 6, 2022
NCT03468686 Completed N/A The Study of Effectiveness of rTMS on Rumination and Anhedonia in Patients With Major Depressive Disorder December 21, 2016 October 30, 2020
NCT01078948 Completed N/A Transcranial Direct Current Stimulation (tDCS) in the Treatment of Major Depressive Disorder (MDD) February 2008 October 2010
NCT02709161 Completed N/A Effects of Amygdala Neurofeedback on Depressive Symptoms October 2016 April 1, 2020
NCT02615119 Completed N/A Neural Basis of Meal Related Interoceptive Dysfunction in Anorexia Nervosa October 1, 2015 June 2023
NCT00075296 Completed FMRI Study of Performance During a Probabilistic Reversal Learning Task in Depression January 5, 2004 April 21, 2008
NCT03078322 Completed Phase 2 AV-101 as Adjunct Antidepressant Therapy in Patients With Major Depression March 5, 2018 October 1, 2019
NCT01568307 Completed Phase 4 Major Depressive Disorder - Understanding The Link Between The Brain And The Heart May 2012 December 2020
NCT05731323 Completed Phase 1 D-Cycloserine+iTBS PK Study October 12, 2022 June 22, 2023
NCT01515215 Completed N/A Repetitive Transcranial Magnetic Stimulation (rTMS) for Treatment Resistant Depressive Disorder July 2008 October 2016
NCT00006286 Completed Phase 3 Treatment for Adolescents With Depression Study (TADS) September 1998 March 2004
NCT00644358 Completed Phase 3 A One Year Open Label Study Assessing the Safety and Tolerability of Vilazodone in Patients With Major Depressive Disorder (MDD) December 31, 2007 May 31, 2009
NCT04479852 Completed Phase 2 A Study of the Safety and Efficacy of SP-624 in the Treatment of Adults With Major Depressive Disorder September 30, 2020 June 27, 2022
NCT00073203 Completed Phase 2 A 6 Week Study to Determine the Effectiveness of R228060 in Adult Subjects With Major Depressive Disorder May 2004
NCT02033369 Completed Phase 4 Imaging Dopamine Release in Depression February 2014 July 2017
NCT01742832 Completed Phase 2 Double-Blind Treatment of Major Depressive Disorder With Vilazodone May 2013 March 2016
NCT02209142 Completed N/A Blood Biomarkers in Major Depression February 22, 2012 November 10, 2022
NCT03569475 Completed Phase 3 Efficacy, Safety, and Tolerability of Levomilnacipran ER in Pediatric Patients (7-17 Years) With Major Depressive Disorder July 6, 2018 March 1, 2021
NCT00035282 Completed Phase 3 Treatment of Patients With Major Depressive Disorder With MK0869 (0869-060)(COMPLETED) September 2001 December 2003
NCT05081167 Completed Phase 3 A Study to Assess the Efficacy and Safety of REL-1017 as Monotherapy for Major Depressive Disorder (MDD) June 2, 2021 September 14, 2022
NCT01372150 Completed Phase 3 A Study Of DVS SR In Treatment Of Children And Adolescent Outpatients With MDD November 17, 2011 March 20, 2015
NCT02456948 Completed Phase 2 Adjunct Minocyline in Treatment-resistant Depression January 2015 August 7, 2020
NCT04268316 Completed N/A Virtual Reality Behavioral Activation: An Intervention for Major Depressive Disorder May 18, 2020 January 15, 2021
NCT00179283 Completed Phase 3 Sertraline vs. Venlafaxine XR April 2002 April 2003
NCT00042575 Completed Phase 3 Dose Escalation, Double-Blind Treatment With Duloxetine Hydrochloride Once Daily Dosing for Evaluation of Safety in Major Depression June 2002 August 2002
NCT04179526 Completed N/A Transdiagnostic Internet-delivered REBT Intervention for Adolescents' Internalizing Problems January 25, 2020 December 30, 2022
NCT01355081 Completed Phase 3 Efficacy Study of Vortioxetine (Lu AA21004) for Treatment of Major Depressive Disorder May 2011 December 2012
NCT00092911 Completed Phase 3 Study Evaluating DVS-233 SR in Adult Outpatients With Major Depressive Disorder May 2005
NCT01180400 Completed Phase 3 A Study to Assess the Efficacy and Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder September 2010 September 2011
NCT01428661 Completed Phase 2/Phase 3 Melatonin Agonist Effects of Tasimelteon Versus Placebo in Patients With Major Depressive Disorder September 2011 May 2013
NCT03866252 Completed Phase 2 LSD Therapy for Persons Suffering From Major Depression November 1, 2019 December 1, 2022
NCT00733668 Completed Phase 2 Efficacy of SEROQUEL in Selective Serotonin Reuptake Inhibitors (SSRI)-Resistant Major Depressive Disorder March 2006 November 2007
NCT01299272 Completed Phase 3 A Study in Prevention of Re-emergence of Depression Symptoms May 2011 November 2013
NCT02999269 Completed Phase 4 ECT Pulse Amplitude and Medial Temporal Lobe Engagement October 2016 March 23, 2020
NCT04117789 Completed N/A Feasibility of Internet-delivered CBT for Adolescents With Depression October 14, 2019 October 21, 2020
NCT00789854 Completed Phase 3 Comparing Quetiapine XR Monotherapy and Augmentation With Lithium Augmentation in TRD Patients November 2008 August 2009
NCT03203954 Completed N/A Testing the Neuroscience of Guided Learning in Depression May 1, 2016 December 2021
NCT03156556 Completed N/A Improving Access to the Treatment of Anxiety and Depression Among Young Adults May 15, 2017 January 31, 2018
NCT04069819 Completed N/A The Phosphodiesterase-3 Inhibitor Cilostazol as an Adjunctive to Antidepressants in Patients With Major Depressive Disorder. August 1, 2019 December 31, 2021
NCT00714779 Completed N/A Fluoxetine vs. Brief Psychotherapy for Major Depression January 2000 December 2004
NCT04162522 Completed Phase 3 Canadian Biomarker Integration Network for Depression (CAN-BIND) - Validation Study December 23, 2019 December 31, 2022
NCT01571453 Completed Phase 3 Study of Vortioxetine (Lu AA21004) in Major Depressive Disorder in Asian Countries May 2012
NCT05386329 Completed N/A Therapist-Guided Smartphone-Delivered CBT for MDD May 11, 2022 August 7, 2023
NCT05553691 Completed Phase 1 SPL026 With or Without SSRIs in Participants With MDD December 13, 2022 August 3, 2023
NCT00289523 Completed EEG Biomarkers for Predicting Response to Antidepressant Therapy January 2006 July 2007
NCT00367341 Completed N/A Imaging Predictors of Treatment Response in Depression August 2006 July 2013
NCT00108979 Completed Phase 3 Study of Escitalopram in Adult Patients With Major Depressive Disorder March 2005 July 2006
NCT02149836 Completed Phase 2 Study to Treat Major Depressive Disorder (MDD) With a New Medication August 2014 December 2016
NCT00408031 Completed Phase 2 D-cycloserine for Major Depressive Disorder January 2007 May 2010
NCT04688164 Completed Phase 3 A Study to Assess the Efficacy and Safety of REL-1017 as Adjunctive Treatment for Major Depressive Disorder (MDD) January 8, 2021 November 10, 2022
NCT02436239 Completed Phase 3 A Study of Vilazodone in Pediatric Patients With Major Depressive Disorder May 2, 2015 July 23, 2018
NCT01243957 Completed Phase 1 A Study to Measure if There is Any Difference in How the Body Breaks Down or Inactivates Either Fluoxetine or LY2216684 When Both of These Medicines Are Given Together. October 2010 January 2011
NCT00326105 Completed Phase 3 Efficacy and Safety of Quetiapine Fumarate Sustained Release (SEROQUEL SR) in Combination With an Antidepressant in the Treatment of Major Depressive Disorders April 2006 July 2007
NCT02720198 Completed Phase 3 Levomilnacipran ER vs. Adjunctive Quetiapine for Adults With Inadequate Relief With SSRIs in MDD January 23, 2017 June 12, 2018
NCT02646449 Completed Phase 2 Treatment of Young Adults With Comorbid AUD/MDD: A Pilot Medication Trial June 2015 December 2016
NCT01640080 Completed Phase 2 A Study of the Efficacy of Intravenous Esketamine in Adult Patients With Treatment-Resistant Depression June 27, 2012 June 3, 2013
NCT02085135 Completed Phase 3 A Study of Different Titration Schedules of ALKS 5461 in Adults With Major Depressive Disorder (MDD) February 2014 September 2014
NCT00464711 Completed Phase 4 Brain GABA Levels and Treatment Response in Major Depressive Disorder September 2006 September 2009
NCT02051413 Completed Phase 4 Beta-arrestins and Response to Venlafaxine in Major Depressive Disorder (MDD) (DEPARRESTCLIN) February 18, 2014 May 2018
NCT04328103 Completed Mechanisms of Emotion Regulation Underlying Successful CBT in Depression November 25, 2020 June 2, 2023
NCT06439797 Completed Inflammatory Markers as Predictors of the Efficacy of Electroconvulsive Therapy (ECT) in Major Depression Patients November 29, 2018 July 9, 2020
NCT00876343 Completed Phase 3 Study of Aripiprazole as an Adjunctive Therapy in Patients With Major Depressive Disorder March 2009 July 2012
NCT02229188 Completed N/A Games to Overcome Late Life Depression December 2013 August 31, 2018
NCT03131050 Completed Phase 4 Effectiveness Study of Scopolamine Combined With Escitalopram in Patients With MDD March 15, 2017 March 8, 2018
NCT00969150 Completed Phase 3 Safety and Efficacy of Levomilnacipran ER (F2695 SR) in Major Depressive Disorder September 2009
NCT01056289 Completed Phase 4 Study Comparing Discontinuation Symptoms Of DVS SR In Subjects With Major Depressive Disorder (MDD) March 2010 February 2011
NCT03181529 Completed Phase 2 Effects of Psilocybin in Major Depressive Disorder August 10, 2017 December 2, 2020
NCT04285515 Completed Phase 3 Clinical Trial Evaluating Lumateperone Monotherapy in the Treatment of Bipolar Depression or Major Depressive Disorder February 27, 2020 November 30, 2022
NCT00531947 Completed Phase 4 Phase IV:Safety and Efficacy of EMSAM in Adolescents With Major Depression July 2007 October 2010
NCT02624102 Completed Phase 3 Efficacy of Trial-Based Cognitive Therapy and Behavioral Activation in Treatment of Depression September 2015 December 2019
NCT02593643 Completed Early Phase 1 Effect of Ketamine vs. Active Placebo on Suicidal Ideation in Depressed Inpatients With Major Depressive Disorder or Bipolar Depression. January 2016 April 2017
NCT01838876 Completed Phase 3 Long-term Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy in Patients With Major Depressive Disorder April 29, 2013 July 27, 2015
NCT02395978 Completed Phase 2 A Phase II Study of PDC-1421 Capsule to Evaluate the Safety and Efficacy in Patients With Major Depressive Disorder April 10, 2015 March 18, 2019
NCT02053649 Completed N/A Integrated Chronotherapy for Perinatal Depression January 2014 February 28, 2019
NCT01829165 Completed N/A Brain Imaging of rTMS Treatment for Depression September 2012 January 20, 2017
NCT01867749 Completed N/A Group Interpersonal Psychotherapy for Treatment of Major Depressive Disorder Following Perinatal Loss June 2010 June 2014
NCT00533832 Completed N/A Pivotal Trial (D02) of Vagus Nerve Stimulation (VNS) for Treatment-Resistant Depression (TRD) July 2000 July 2005
NCT01887782 Completed N/A Randomized Controlled Trial of Conventional vs Theta Burst rTMS September 2013 October 2016
NCT02099630 Completed Functional and Metabolic Changes in the Course of Antidepressive Treatment March 2014 February 2020
NCT02507297 Completed N/A Sleep-Disordered Breathing and PAP in Perinatal Depression January 2016 April 25, 2020
NCT01189812 Completed Phase 2 Safety and Efficacy Study of Citalopram and Lithium for the Treatment of Depressive Mood Disorder Symptoms March 2010 January 2011
NCT00157547 Completed Phase 4 Quantitative EEG (QEEG) as a Predictor of Treatment Outcome in Depression April 2003 August 2006
NCT03452384 Completed N/A Acupuncture in Depression: From the Clinical Trial, Biomarkers to Molecular Biology November 6, 2014 October 31, 2016
NCT03632434 Completed N/A Transcranial Direct Current Stimulation Therapy for Major Depression October 14, 2019 November 26, 2021
NCT03265340 Completed N/A Clinical Effect of dTMS in Major Depressive Disorder September 2014 September 2016
NCT00242229 Completed N/A Study Evaluating DVS-233 SR in Elderly Outpatients With Major Depressive Disorder October 2004 October 2005
NCT02998762 Completed Long-Term Follow Up Study February 3, 2016 July 29, 2019
NCT03722095 Completed N/A Research on the Effects of Combined Neurostimulation Protocols on Stress October 29, 2018 October 31, 2020
NCT05685758 Completed N/A A Treatment for Depression Via a Gamified Mobile Phone Application Based on a New Cognitive Model November 3, 2022 July 31, 2023
NCT02026622 Completed N/A Comparative Study of Physiological and Cerebrovascular Reactivity in Depression, at the Three Phases of Emotion February 2013 August 2015
NCT00437125 Completed Phase 4 Study on the Tolerability of Duloxetine in Depressed Patients With Parkinson's Disease March 2007 July 2009
NCT02273063 Completed N/A rTMS for PTSD Comorbid With Major Depressive Disorder October 2014 April 22, 2016
NCT03193398 Completed Phase 2 BTRX-246040 Administered Once Daily to Patients With Major Depressive Disorder June 12, 2017 December 12, 2018
NCT00931775 Completed Phase 2 Citalopram Versus Citalopram Plus Pindolol in Major Depressive Disorder December 2002 November 2005
NCT05203341 Completed Phase 2 Study to Assess the Efficacy and Safety of NBI-1065845 in Adults With Major Depressive Disorder (MDD) February 21, 2022 February 21, 2024
NCT05165394 Completed Phase 2 Study to Evaluate the Efficacy and Safety of Once-Weekly Oral NBI-1065846 in the Treatment of Anhedonia in MDD November 30, 2021 September 7, 2023
NCT04727229 Completed Phase 4 Stellate Ganglion Block for Major Depressive Disorder. September 23, 2021 March 10, 2022
NCT00435279 Completed Phase 3 A Study of Eszopiclone Co-administered With Venlafaxine in Subjects With Major Depressive Disorder and Insomnia June 2007 July 2009
NCT01731678 Completed N/A Transcranial Magnetic Stimulation for Adolescent Depression November 2012 December 2018
NCT00252356 Completed Phase 3 Efficacy and Safety of SR58611A in Patients With Major Depressive Disorder September 2005 May 2007
NCT00612807 Completed Phase 1/Phase 2 Treatment of Mood and Marriage Study (TOMMS) July 2006 June 2010
NCT00672958 Completed Phase 3 Efficacy and Safety of Vortioxetine (Lu AA21004) in Treating Adults With Major Depressive Disorder April 2008 November 2008
NCT02900092 Completed N/A Augmentation of Treatment-Resistant Depression With An Analog of the Neuroactive Steroid Allopregnanolone November 2016 January 12, 2018
NCT01263093 Completed Phase 1 A Pharmacokinetic Study on the Effect of LY2216684 on the Active Metabolite of Clopidogrel December 2010 March 2011
NCT02307617 Completed Glutamate Probes in Adolescent Depression August 1, 2014 April 17, 2017
NCT05523076 Completed Transdiagnostic Markers of Cognitive Symptoms in Disorders Affective. March 15, 2018 December 31, 2021
NCT00296933 Completed Phase 3 Memory Functioning and Antidepressant Treatment December 2005
NCT00511810 Completed Phase 2/Phase 3 Omega-3 Fatty Acids as Adjunct Treatment for Major Depressive Disorder August 2007 March 2011
NCT02067793 Completed Phase 2 Study of Intravenous NRX-1074 in Patients With Major Depressive Disorder March 2014 February 2015
NCT04288895 Completed Phase 4 Open-label, Flexible-dose Study of Vortioxetine in Patients With Depression in India February 20, 2020 March 12, 2022
NCT00042029 Completed Phase 3 Treatment of Patients With Major Depressive Disorder With MK0869 (0869-073) June 18, 2002 October 3, 2003
NCT02992158 Completed N/A Feasibility of a Behavioral Activation Trial March 2016 November 2019
NCT05815459 Completed Mobile Observation Of Depression July 15, 2022 February 1, 2023
NCT00096642 Completed N/A Cognitive Behavioral Therapy for Early-Onset Depression June 2002 June 2006
NCT03736538 Enrolling by invitation Phase 1 Nitrous Oxide- Suicidal Ideation October 30, 2018 July 2024
NCT04040062 Enrolling by invitation N/A Spectral Correlation Coefficient-based TMS June 25, 2019 October 2025
NCT05645575 Enrolling by invitation N/A In-patient SCC TMS January 22, 2023 February 22, 2026
NCT05061719 Enrolling by invitation Phase 3 An Open-label Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder October 8, 2021 May 2024
NCT04209296 Enrolling by invitation Chart Review of Patients Undergoing Ketamine Infusions December 3, 2019 December 2023
NCT04166864 Enrolling by invitation N/A Spectral Correlation Coefficient-determine TMS for Depression June 16, 2019 December 16, 2024
NCT06126198 Enrolling by invitation N/A rTMS Feasibility Study on Adolescent Depression Stimulation January 1, 2022 December 31, 2023
NCT04497350 Enrolling by invitation N/A Transcranial Magnetic Stimulation vs Theta Burst Stimulation in Major Depressive Disorder January 6, 2020 December 2024
NCT05910957 Enrolling by invitation Multi-Omic, Clinomic and Digitomic Attributes of Major Depression for Integrative Analytics August 2, 2023 October 2024
NCT04509102 Enrolling by invitation Early Phase 1 Psychostimulant Augmentation of Repetitive TMS for the Treatment of Major Depressive Disorder September 27, 2021 September 19, 2025
NCT05024149 Enrolling by invitation N/A Assessing the Impact of Electroacupuncture on Facial Thermal Characteristics of Major Depressive Disorder Patients Based on Infrared Thermal Imaging Technology July 1, 2021 December 30, 2024
NCT05775809 Enrolling by invitation Prospective Clinical Cohort Study of Depression June 15, 2023 May 20, 2024
NCT05686668 Enrolling by invitation Evolution of the Sensory Profile in Depression January 10, 2022 January 10, 2024
NCT05565352 Enrolling by invitation Observation of Ketamine Treatment Safety and Tolerability in Adult Psychiatry Clinic Medical University of Gdańsk Inpatients September 1, 2022 December 31, 2027
NCT05701345 Enrolling by invitation N/A Study of Virtual Reality-based Medical Device for Patients With Depressive Disorder March 9, 2023 December 15, 2024
NCT05227612 Enrolling by invitation Early Phase 1 Psilocybin-assisted CBT for Depression June 27, 2023 December 2025
NCT06002100 Enrolling by invitation Prediction of REsponse to Depression Interventions Using Clinical and TD-fNIRS Measurements August 14, 2023 December 2024
NCT05487911 Enrolling by invitation N/A Cortical rTMS as a Treatment for Depression August 1, 2024 August 4, 2027
NCT00071708 No longer available Duloxetine Compassionate Use in Patients Who Have Completed a Previous Neuroscience Duloxetine Clinical Trial
NCT04594616 Not yet recruiting N/A Waitlist-Control Trial of Smartphone CBT for Major Depressive Disorder (MDD) September 1, 2024 December 1, 2027
NCT06183359 Not yet recruiting N/A Self-Identification Program February 1, 2024 February 1, 2027
NCT05989412 Not yet recruiting N/A Mobile Screening for Major Depressive Disorder in Adults From an Ethnically and Socioeconomically Diverse Population. February 1, 2024 September 2026
NCT06247839 Not yet recruiting Phase 3 The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive Disorder April 1, 2024 June 30, 2026
NCT06105762 Not yet recruiting N/A Ketogenic Diet for Depression January 1, 2024 July 1, 2027
NCT05915312 Not yet recruiting Exosome for Early Diagnosis of Bipolar Affective Disorder June 15, 2023 December 31, 2024
NCT06452290 Not yet recruiting N/A PET Biomarker Study for Antidepressant Response Prediction in Major Depressive Disorder September 1, 2024 March 1, 2027
NCT06072898 Not yet recruiting Phase 2 A Randomized Neuroimaging Trial of Psilocybin in Depression August 2024 November 2027
NCT05295888 Not yet recruiting N/A Temporal Interference and Depression January 2023 July 2023
NCT06423781 Not yet recruiting Phase 2 Long-term Safety Study of BHV-7000 in Participants With Major Depressive Disorder (MDD) July 2024 November 2027
NCT06027177 Not yet recruiting Personalized, Predictive, Precise & Preventive Medicine for Major Depression September 2023 August 2025
NCT06462820 Not yet recruiting Phase 2/Phase 3 SAINT for MDD in an Inpatient Setting Follow-on June 30, 2024 February 28, 2026
NCT06443242 Not yet recruiting N/A Efficacy and Safety of Low-dose Laser Acupuncture on Treating Insomnia Associated With Major Depressive Disorder September 1, 2024 September 1, 2027
NCT05785312 Not yet recruiting N/A Development of Online EMDR Therapy System and Its Comparative Testing With Face-to-Face EMDR Therapy for Treatment of Anxiety and Depressive Disorders in Pakistan July 1, 2023 August 1, 2025
NCT05506462 Not yet recruiting Phase 4 An EEG Study of Intravenous Ketamine for Major Depression Disorder January 2023 February 2024
NCT06384209 Not yet recruiting N/A The Friendship Bench Plus Trial July 1, 2024 February 28, 2027
NCT06282146 Not yet recruiting Early Phase 1 Testing a Transdiagnostic TMS Treatment Target April 1, 2024 April 1, 2026
NCT05613972 Not yet recruiting N/A Brief Suicide & Trauma Therapy for Suicide Risk March 2024 January 2027
NCT05877885 Not yet recruiting N/A Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics August 1, 2024 December 2028
NCT05957341 Not yet recruiting N/A pBFS Guided 20min Inter-session Interval rTMS Treatment for MDD July 30, 2023 August 30, 2024
NCT06168175 Not yet recruiting Phase 2 Feasibility of Conducting a Clinical Trial Assessing Efficacy of Lactate as Adjunctive Therapy in Patients With Major Depressive Disorder January 2024 January 2028
NCT05812001 Not yet recruiting N/A Exergames-acceptance and Commitment Therapy Program for Treatment of Major Depressive Disorder June 1, 2024 May 31, 2026
NCT05644301 Not yet recruiting Phase 3 INflammation-based Stratification for Immune-Targeted Augmentation in Major Depressive Disorder January 2023 September 2026
NCT06443216 Not yet recruiting N/A Sleep Modulation to Treat Depression June 2024 July 2026
NCT04441008 Not yet recruiting N/A Accelerated iTBS for Depression and Suicidality December 2025 July 2029
NCT05352113 Not yet recruiting N/A Intradermal Needle Therapy for Major Depressive Disorder May 1, 2022 December 30, 2025
NCT05988840 Not yet recruiting Acquisition and Analysis of Relationships Between Longitudinal Emotional Signals Produced by an Artificial Intelligence Algorithm and Self-questionnaires Used in the Psychiatric Follow-up of Patients With Mood and/or Anxiety Disorders: a Real-Environment Study. October 17, 2023 October 17, 2024
NCT05990855 Not yet recruiting N/A Using Sleep Wearables to Adapt Cognitive-behavioral Therapy for Insomnia in the Context of Depression (CBTiA) August 2023 January 2025
NCT05932407 Not yet recruiting A Database Survey of Comparison The Risk of Haemorrhage Between Vortioxetine Tablet Treatment and Selective Serotonin Reuptake Inhibitor (SSRI) Treatment in Participants With Depression June 1, 2024 July 31, 2024
NCT06234176 Not yet recruiting N/A Impact of Psychomotor Therapy on the Quality of Life in Depression April 2024 August 2026
NCT05353543 Not yet recruiting N/A Acupuncture Therapy Based on Biological Specificity of Acupoints for Major Depressive Disorder May 1, 2022 December 30, 2025
NCT06402955 Not yet recruiting Imaging Depression in Parkinson's Disease May 2024 December 2029
NCT06462196 Not yet recruiting Natural History of Depression, Bipolar Disorder and Suicide Risk June 23, 2024 June 1, 2030
NCT05643898 Not yet recruiting N/A "Mamá, te Entiendo" App-based Intervention for Reducing Depressive Symptoms in Postpartum Women March 1, 2023 November 1, 2023
NCT04156425 Not yet recruiting N/A The Role of PKC Activation in the Immune-inflammatory Mechanism of Major Depressive Depression July 1, 2020 December 31, 2024
NCT06274112 Not yet recruiting N/A Using TMS to Understand Neural Processes of Social Motivation September 2024 September 2029
NCT05118594 Not yet recruiting N/A Testing a Precision Psychotherapy System for Low-income Patients February 2026 November 2026
NCT06132178 Not yet recruiting Phase 2 Psilocybin rTMS for Treatment Resistant Depression June 1, 2024 May 15, 2027
NCT05866575 Not yet recruiting N/A Prediction of the Therapeutic Response in Depression Based on Neuro-computational Modeling Assessment of Motivation June 1, 2023 December 31, 2026
NCT06309472 Not yet recruiting Phase 2 Trial of Mirtazapine for Depression in IBD March 2024 June 2026
NCT03833206 Not yet recruiting Phase 1/Phase 2 A Phase I/II Study of PDC-1421 for Treating Depression in Cancer Patients July 15, 2024 February 28, 2025
NCT06228391 Not yet recruiting Phase 2 Ketamine Treatment for PTSD and MDD in TBI March 2024 March 2027
NCT06255561 Not yet recruiting N/A pBFS Guided rTMS Over Different Targets for Treatment-Resistant Depression February 20, 2024 January 30, 2025
NCT06093906 Not yet recruiting N/A Positive Processes and Transition to Health (PATH) July 1, 2024 June 30, 2026
NCT06376734 Not yet recruiting Phase 2 Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness June 1, 2024 June 1, 2030
NCT05547711 Not yet recruiting N/A Prediction and Validation of Unipolar Depression With Psychosocial-somatic Markers in a Naturalistic Cohort Recruited in an Outpatient Setting October 15, 2022 October 15, 2032
NCT06230757 Not yet recruiting Phase 2 Psilocybin for Treatment-Resistant Depression March 1, 2024 March 1, 2025
NCT06229652 Not yet recruiting N/A Stress Management in Depressive Disorder: Resilience Training vs. Yoga: Biological, Epigenetic, and Brain Correlates April 1, 2024 April 1, 2028
NCT06439043 Not yet recruiting N/A Cultural Adaptation of EMDR for Major Depressive Disorder and Compaire Its Online and Face-to-Face Testing August 1, 2024 September 30, 2025
NCT03693105 Not yet recruiting Phase 2/Phase 3 The Effects of SAINT® Neuromodulation System on Explicit and Implicit Suicidal Cognition June 30, 2024 February 28, 2026
NCT05539495 Not yet recruiting Exercise Recovery From Persistent Depression: A Thematic Analysis September 2022 August 2023
NCT02129751 Not yet recruiting Phase 4 Efficacy and Safety of Bupropion Hydrobromide in Adolescents and Children With Major Depressive Disorder June 2023 November 2024
NCT05725785 Not yet recruiting N/A Technology-Assisted Implementation of a Mobile Health Program for Serious Mental Illness June 1, 2023 March 31, 2025
NCT03804619 Not yet recruiting N/A Accelerated Intermittent Theta-Burst Stimulation for Opiate Use Disorder June 1, 2024 December 1, 2025
NCT05568823 Not yet recruiting N/A Biomarkers of ANTidepressant RESponse and Development Risk of Bipolar Disorder November 1, 2022 January 2, 2025
NCT05707299 Not yet recruiting N/A The Effect of Intradermal Acupuncture on Gallbladder Meridian Points on Cerebral Hemodynamics in Relevant Brain Regions for Major Depressive Disorder Based on fNIRS Technology February 1, 2023 May 31, 2024
NCT06391723 Not yet recruiting N/A Clinical, Cognitive and Neural Effects of Potentiation of ECT by rTMS in Treatment-Resistant Depression June 2024 September 2026
NCT05675800 Not yet recruiting Phase 2 Psilocybin for Major Depressive Disorder January 1, 2024 March 31, 2025
NCT06328140 Not yet recruiting Sleep Quality, Cognitive Performance, and Computerized Cognitive Training April 15, 2024 April 14, 2026
NCT06410599 Not yet recruiting Phase 2 Pharmacologic Treatment Augmentation in Chronic Depression May 2024 July 2026
NCT06450704 Not yet recruiting N/A Cerebral and Anti-inflammatory Response Through Exercise - Mechanisms In Depressive Disorders September 1, 2024 December 31, 2026
NCT06404320 Not yet recruiting N/A Physical Activity Program for TRD May 2024 August 2025
NCT05603104 Not yet recruiting Phase 3 Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure July 31, 2024 June 30, 2026
NCT05710887 Not yet recruiting Phase 2 N2O for Acute Suicidality and Depression in the ED October 1, 2024 December 1, 2025
NCT06426485 Not yet recruiting Phase 4 To Evaluate the Long-term Efficacy and Safety of Toludevenlafaxine Hydrochloride Sustained-release Tablets May 30, 2024 June 30, 2027
NCT06025838 Not yet recruiting N/A Positive Feedback vs. No-Feedback Games for Behavioral Change September 1, 2023 November 1, 2023
NCT04344678 Recruiting N/A The Phosphodiesterase 5 Inhibitor Sildenafil as an Adjunct to Antidepressants in Major Depressive Disorder Patients January 1, 2020 December 31, 2024
NCT06003309 Recruiting N/A Frequency and E-field Enhancement of ITBS for Depression (FREED) August 31, 2023 April 1, 2025
NCT04751071 Recruiting Phase 1/Phase 2 The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients February 1, 2021 December 1, 2025
NCT06345651 Recruiting N/A Brain Oscillation-synchronized Stimulation of the Frontal Cortex in Major Depressive Disorder September 1, 2023 August 2025
NCT05772221 Recruiting N/A The Role of Social Determinants in Cardiovascular Health and Vascular Function June 29, 2023 December 31, 2023
NCT05840861 Recruiting Using 18F-FPEB PET to Identify mGLUR5 Availability in Affective Disorders November 5, 2020 September 5, 2023
NCT05480150 Recruiting N/A Chinese Longitudinal and Systematic Study of Bioplar Disorder November 1, 2021 December 31, 2026
NCT06159595 Recruiting N/A Behavioral and Neuronal Correlates of Human Mood States December 1, 2023 November 30, 2025
NCT06417437 Recruiting Phase 4 Non-invasive BCI and Application Verification for Depressed People July 1, 2023 July 31, 2027
NCT06236880 Recruiting Phase 2 A Phase 2a Study to Evaluate the Safety and Tolerability of GM-2505 in Patients With MDD January 31, 2024 July 29, 2024
NCT05537584 Recruiting Phase 4 SMART Trial to Predict Anhedonia Response to Antidepressant Treatment September 30, 2022 November 1, 2024
NCT04788524 Recruiting N/A Neural Correlates of Stress and Perceived Control in Adolescent Depression April 23, 2021 April 30, 2025
NCT04296604 Recruiting N/A Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations September 2014 September 2024
NCT04975724 Recruiting Phase 4 Safety of Liposom With Citalopram in Elderly Patients With Major Depressive Disorder April 18, 2019 December 2025
NCT05850689 Recruiting Phase 3 Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder May 2, 2023 October 2025
NCT05054699 Recruiting Phase 2/Phase 3 Electro-Magnetic Convulsive Therapies for Depression: a Non-inferiority Study May 31, 2021 June 1, 2025
NCT04999553 Recruiting N/A Left vs. Right Non-Inferiority Trial November 8, 2021 February 1, 2026
NCT05733546 Recruiting Phase 2 A Phase II, Multicentre, Randomised, Double-blind, Controlled Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of COMP360 in Participants With Recurrent Major Depressive Disorder January 30, 2023 November 2024
NCT04255784 Recruiting N/A High Dose Accelerated iTBS for Depression February 6, 2020 February 2025
NCT03265808 Recruiting Phase 1/Phase 2 Allogeneic Human Mesenchymal Stem Cell Infusion vs Placebo in Alcohol Use Disorder and Major Depression. March 18, 2018 April 2025
NCT04850911 Recruiting N/A Reward Emotion Learning and Ketamine Study August 25, 2021 May 2023
NCT04422652 Recruiting Phase 2 Combination of Novel Therapies for CKD Comorbid Depression September 24, 2020 April 1, 2026
NCT05832619 Recruiting N/A Intradermal Acupuncture Versus Sham Acupuncture and SSRI for Treating Adolescents With Major Depressive Disorder November 1, 2022 December 30, 2025
NCT05859698 Recruiting Phase 4 Study of the Effectiveness of Valbenazine on Patient- and Clinician-Reported Outcomes in Participants With Tardive Dyskinesia May 25, 2023 December 2024
NCT04138680 Recruiting N/A Real-time Biofeedback With 7-Tesla MRI for Treatment of Depression October 9, 2019 October 2024
NCT05137197 Recruiting N/A Confirm the Effectiveness of Predictix Genetics Antidepressant -Guided Treatment in Adults With MDD October 4, 2021 December 2024
NCT04032301 Recruiting Phase 1 Repeated Ketamine Infusions for Comorbid PTSD and MDD in Veterans September 30, 2019 April 1, 2025
NCT03973268 Recruiting Phase 1 Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression January 21, 2020 February 1, 2025
NCT06254612 Recruiting Phase 2 A Study of the Efficacy and Safety of SP-624 in the Treatment of Adults With Major Depressive Disorder March 25, 2024 July 11, 2025
NCT05317481 Recruiting N/A Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily Rhythms April 1, 2022 March 31, 2025
NCT05913960 Recruiting N/A Accelerated Intermittent Theta-Burst Stimulation Ameliorate Major Depressive Disorder by Regulating CAMKII Pathway February 9, 2023 March 15, 2027
NCT05680220 Recruiting N/A 40 Hz Light Neurostimulation for Patients With Depression (FELIX) October 5, 2023 April 2025
NCT05573074 Recruiting N/A Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression - R33 April 1, 2023 January 31, 2026
NCT03505905 Recruiting Phase 1/Phase 2 A Neurosteroid Intervention for Menopausal and Perimenopausal Depression September 1, 2018 January 31, 2025
NCT04461327 Recruiting N/A Psychophysiological Study of Pain Perception in Depressed Patients With Suicidal Risk November 25, 2020 March 2025
NCT06132581 Recruiting N/A Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression January 24, 2024 July 31, 2026
NCT06058039 Recruiting Phase 3 Study to Assess the Effects of Oral NMRA-335140 in Participants With Major Depressive Disorder December 21, 2023 June 2025
NCT04518592 Recruiting Model-based Defining of Subtypes of Depression and Optimal Treatment: an Integrated Techniques Module. December 22, 2020 September 30, 2024
NCT05135897 Recruiting The Neurobiological Fundaments of Depression and Its Relief Through Neurostimulation Treatments September 27, 2021 December 31, 2025
NCT05682183 Recruiting N/A Multi-domain Psychoeducation Self-management Program for Adults With MDD in Singapore January 3, 2023 December 31, 2024
NCT05051618 Recruiting N/A Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis April 1, 2023 March 31, 2025
NCT06357832 Recruiting N/A New Investigational Stimulation Protocol for Treatment of Major Depression Disorder (MDD) April 29, 2024 February 28, 2025
NCT05543421 Recruiting N/A Transcranial Magnetic Stimulation in Patients With a Depressive Episode - RCT Trial January 1, 2019 December 30, 2024
NCT06080646 Recruiting Reward Processing and Depressive Subtypes: Identifying Neural Biotypes June 1, 2021 September 1, 2025
NCT05527951 Recruiting N/A Enhanced Measurement-Based Care Effectiveness for Depression (EMBED) Study September 3, 2022 December 31, 2022
NCT04855747 Recruiting Phase 3 A Study to Assess the Efficacy and Safety of REL-1017 as Adjunctive Treatment for Major Depressive Disorder (MDD) March 30, 2021 June 2024
NCT05811897 Recruiting N/A RESILIENT : A Self-Managed Online Platform for Victims of Sexual Assault August 1, 2022 March 31, 2024
NCT05976009 Recruiting N/A pBFS-Guided rTMS Therapy Over Different Targets for Treatment-Resistant Depression August 29, 2023 September 20, 2024
NCT04748276 Recruiting Tracking Response to Antidepressants in Advance of Investigational Trials January 2, 2019 December 31, 2023
NCT06054321 Recruiting N/A Psychopharmacotherapy for Depressive Patients August 3, 2022 December 31, 2030
NCT06163612 Recruiting Effect of Suicidality on Social Cognition September 1, 2022 December 31, 2024
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NCT04041479 Recruiting Phase 3 Biomarker-guided rTMS for Treatment Resistant Depression September 17, 2021 August 2026
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NCT06110897 Recruiting N/A RESISTance Exercise for Depression Trial January 1, 2024 May 31, 2028
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NCT04410575 Recruiting N/A Mental Health Assessment and Prescribing by Alberta Pharmacists March 22, 2023 December 30, 2024
NCT06213324 Recruiting Phase 4 Neural Circuit Effects of Ketamine in Depression January 31, 2024 April 30, 2028
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NCT02811198 Recruiting Pain, Reward, Attention and Neurocircuitry: Biomarkers of Suicidality January 2017 August 2026
NCT06070766 Recruiting RIVER At Home Ketamine Protocols October 1, 2023 April 1, 2029
NCT03898297 Recruiting Imaging mGluR5 and Synaptic Density in Psychiatric Disorders January 11, 2017 April 2025
NCT05045378 Recruiting Phase 4 Low-dose Ketamine Infusion Among Adolescents With Treatment-resistant Depression March 15, 2022 December 2026
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NCT06306248 Recruiting Immune Activation, Neural Plasticity and Depression March 3, 2023 May 9, 2025
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NCT02752542 Recruiting Phase 4 Personalized Indications for CBT and Antidepressants in Treating Depression October 31, 2016 May 2023
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NCT06223880 Recruiting Phase 4 A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms December 27, 2023 March 2026
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NCT04952532 Recruiting N/A A Novel Cognitive Remediation Intervention Targeting Poor Decision-making and Depression in Veterans at High Risk for Suicide: A Safe, Telehealth Approach During the COVID-19 Pandemic January 1, 2022 December 31, 2024
NCT04502758 Recruiting N/A Sequential Bilateral Accelerated Theta Burst Stimulation in Adolescents With Suicidal Ideation April 4, 2022 December 2027
NCT04543773 Recruiting N/A Individualized Targeting and Neuromodulation of Late-Life Depression October 1, 2020 December 31, 2025
NCT06196346 Recruiting N/A Inter-Brain Synchrony in Psychotherapy for Depression November 23, 2021 June 2024
NCT05973851 Recruiting Phase 3 The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. May 31, 2024 June 30, 2026
NCT05693922 Recruiting N/A Augmenting Single-session Behavioral Activation (BA) With Delta-beta Transcranial Alternating Current Stimulation (tACS) for the Treatment of Depression February 9, 2023 March 2024
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NCT05172271 Recruiting N/A Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD November 8, 2022 October 31, 2025
NCT04392947 Recruiting N/A Treatment of Major Depressive Disorder With Bilateral Theta Burst Stimulation September 29, 2020 September 2025
NCT05017311 Recruiting Phase 4 Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D) January 20, 2023 April 30, 2029
NCT04061148 Recruiting N/A Near Infrared Spectroscopy (NIRS) for Assessment of Depression January 4, 2019 December 30, 2026
NCT06329414 Recruiting Acceptability and Feasibility of Transcranial Magnetic Stimulation (TMS) for Depression in Multiple Sclerosis January 16, 2024 January 2026
NCT04116528 Recruiting Phase 3 Opiate Suicide Study in Patients With Major Depression August 1, 2020 July 2024
NCT06063369 Recruiting Phase 2 PEA vs. Placebo for Major Depression December 21, 2022 December 21, 2024
NCT05922878 Recruiting Phase 2 Study of ALTO-300 in MDD June 8, 2023 May 2025
NCT05583747 Recruiting N/A E-field Guided iTBS for Treatment Resistant Depression October 24, 2022 July 31, 2027
NCT05577494 Recruiting A Trial of Enhanced Versus Standard Measurement-Based Care Implementation for Depression February 10, 2022 December 31, 2023
NCT04615234 Recruiting Clinical Validation of a Combinatorial Pharmacogenomic Approach in Major Depressive Disorder February 1, 2020 March 1, 2023
NCT04979910 Recruiting Phase 2 Targeting IL-17A for Treatment-Resistant Depression August 27, 2021 October 2024
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NCT03711123 Recruiting N/A Group Metacognitive Therapy vs Clinical Management for Depression November 1, 2018 June 2025
NCT04621708 Recruiting N/A Pilot Study of the Safety and Tolerability of L-DLPFC iTBS rTMS for MDD in MS April 30, 2020 April 30, 2024
NCT05224206 Recruiting N/A Neural Mechanisms of Intermittent Theta Burst Stimulation in the Core Depression Network April 26, 2023 June 1, 2025
NCT05757791 Recruiting Phase 2 Sodium-Glucose Cotransporter-2 Inhibitor (SGLT2) in Major Depressive Disorder (MDD) March 17, 2023 August 2025
NCT06452849 Recruiting N/A Amygdala and dLPFC MRI-TIS for Depression in Adolescents May 27, 2024 April 28, 2025
NCT04004169 Recruiting N/A Closed-Loop Deep Brain Stimulation for Major Depression July 18, 2019 June 28, 2035
NCT04827901 Recruiting Phase 2 XEN1101 for Major Depressive Disorder October 19, 2021 December 2024
NCT04637620 Recruiting Phase 2 NMDA Modulation in Major Depressive Disorder June 1, 2017 December 2024
NCT06306209 Recruiting Inflammatory Control of Antidepressant Efficacy: a Pharmaco-epigenetic Approach May 18, 2021 January 14, 2025
NCT05694156 Recruiting N/A Musical Attention Control and Executive Function Training for Adults With MDD August 17, 2023 January 2026
NCT05450432 Recruiting Phase 4 Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression October 13, 2022 June 1, 2025
NCT04448327 Recruiting N/A Impact of Transcutaneous Vagal Nerve Stimulation on Stress Response in Major Depression January 29, 2021 November 15, 2024
NCT05813093 Recruiting N/A Interleaved TMS-fMRI in Ultra-treatment Resistant Depression September 27, 2023 July 7, 2025
NCT05347719 Recruiting N/A Virtual Mindfulness Training for Adults With History of Depression September 1, 2022 June 1, 2024
NCT05655507 Recruiting Phase 1 Zuranolone Pharmacokinetics (PK) and Safety Study Adolescent Participants With Major Depressive Disorder (MDD) April 19, 2023 October 2024
NCT03859297 Recruiting N/A Mechanisms of Rumination Change in Adolescent Depression May 1, 2019 March 2, 2026
NCT05142683 Recruiting N/A Effectiveness of an Integrated Care Pathway for Depression: Cluster Randomized Controlled Trial February 1, 2022 September 30, 2027
NCT04935619 Recruiting N/A Extended Effects of Cannabis Abstinence on Clinical Symptoms and Cognition in Depression July 21, 2021 August 31, 2025
NCT05948839 Recruiting N/A pBFS Guided rTMS Over DMPFC for Treatment-Resistant Depression July 11, 2023 September 1, 2024
NCT04620759 Recruiting Phase 2 Psilocybin Treatment of Major Depressive Disorder With Co-occurring Alcohol Use Disorder April 14, 2021 August 31, 2026
NCT03869736 Recruiting Phase 2 Nitrous Oxide for the Treatment of Major Depressive Disorder January 22, 2019 December 10, 2023
NCT05892744 Recruiting Phase 4 Establishing Multimodal Brain Biomarkers for Treatment Selection in Depression September 30, 2023 August 1, 2026
NCT06026917 Recruiting Phase 4 Assessing Dopamine Transporter Occupancy in the Patients With Depression Brain With Toludesvenlafaxine Hydrochloride Extended-Release Tablets Using 11C-CFT Positron Emission Tomography (PET) September 25, 2023 March 31, 2024
NCT04953208 Recruiting N/A Remotely Non-invasive Brain Stimulation and Videogame to Alleviate Depression June 22, 2021 December 31, 2024
NCT05400785 Recruiting N/A Efficacy of the Mobile Application for Prediction and Prevention of Mood Episode Recurrence Based on Machine Learning May 27, 2022 October 31, 2023
NCT04466345 Recruiting Phase 2 Semaglutide for the Treatment of Cognitive Dysfunction in Major Depressive Disorder October 6, 2021 October 5, 2024
NCT06043401 Recruiting Tracking Brain Biomarkers and Renormalization Associated With Antidepressant Transcranial Magnetic Stimulation Therapy April 4, 2023 April 4, 2025
NCT04183205 Recruiting Phase 4 Predicting SSRI Efficacy in Veterans With PTSD September 11, 2019 September 30, 2025
NCT05259943 Recruiting Phase 2 Microdosing Psychedelics to Improve Mood July 15, 2023 August 2025
NCT05435222 Recruiting N/A Evaluation of a Male-specific Psychotherapeutic Program for Major Depressive Disorders March 15, 2023 October 31, 2025
NCT05174273 Recruiting Phase 2/Phase 3 Neurocognitive Effects of FMT in MDD Patients With and Without IBS April 6, 2022 December 2024
NCT04480918 Recruiting University of Iowa Interventional Psychiatry Service Patient Registry November 2, 2020 August 2050
NCT06235905 Recruiting Phase 2 Open-Label of SPN-820 in Adults With Major Depressive Disorder February 15, 2024 October 15, 2024
NCT06271954 Recruiting The Relationship Between Emotion Regulation and Psychiatric Disorder in Youth March 27, 2023 March 26, 2025
NCT05441969 Recruiting In Vivo Cortical Excitability Modulation in Major Depressive Disorder May 19, 2020 December 31, 2024
NCT06350396 Recruiting N/A pBFS-guided rTMS Over DMPFC for Treatment-Resistant Depression April 17, 2024 June 30, 2025
NCT04821271 Recruiting Phase 2 Antidepressant Effects of TS-161 in Treatment-Resistant Depression June 10, 2021 June 3, 2025
NCT05536414 Recruiting Phase 2 Trial of Centanafadine Efficacy and Safety as Monotherapy or as Adjunct to SSRI in Adults With Major Depressive Disorder September 12, 2022 January 17, 2025
NCT05895747 Recruiting Phase 2 5-HTP and Creatine for Depression R33 Phase September 28, 2023 July 31, 2026
NCT05893173 Recruiting Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Sleep Deprivation June 19, 2023 May 20, 2028
NCT05902312 Recruiting N/A Repetitive Versus Deep Transcranial Magnetic Stimulation for Major Depression January 1, 2024 September 1, 2027
NCT05703256 Recruiting N/A Amygdala Neurofeedback for Depression - Large Scale Clinical Trial June 1, 2023 April 30, 2028
NCT05523817 Recruiting N/A Targeting Specific Brain Networks to Treat Specific Symptoms in Depression March 12, 2024 December 31, 2028
NCT06454695 Recruiting N/A Improving Treatment of Major Depressive Disorder by Reducing Negative Future-Oriented Mental Imagery June 1, 2024 November 1, 2025
NCT05712187 Recruiting Phase 2 Phase 2b Study of ALTO-100 in MDD January 10, 2023 September 27, 2024
NCT05434156 Recruiting Phase 1/Phase 2 ELE-101 Safety & Tolerability Study in Healthy Participants and Patients With Depression October 27, 2022 September 2024
NCT03774641 Recruiting A Pilot Study of Prophylactic Management of Lamotrigine in Pregnant Women December 3, 2018 March 30, 2025
NCT04724447 Recruiting Phase 1/Phase 2 ANTIVIRAL TREATMENT OF CYTOMEGALOVIRUS IN DEPRESSION November 23, 2021 December 2024
NCT05976022 Recruiting N/A pBFS Guided rTMS Therapy Over Different Targets for Treatment-Resistant Depression August 4, 2023 December 20, 2024
NCT04832750 Recruiting Depression-Reduction by Accelerated Personalized NeuroModulation and Its Effects on Sleep May 3, 2021 December 2024
NCT06252701 Recruiting N/A Diet and Depression June 2024 October 2026
NCT04587778 Recruiting Phase 1 Imaging Neural Correlates of Ketamine Using PET/MR October 5, 2020 March 31, 2025
NCT06178731 Recruiting N/A Virtual Reality Reward Training and Transcranial Magnetic Stimulation for Depression October 29, 2021 October 29, 2024
NCT06029426 Recruiting Phase 3 Study to Evaluate the Effects of Oral NMRA 335140 Versus Placebo in Participants With Major Depressive Disorder September 20, 2023 July 2025
NCT05465915 Recruiting Early Phase 1 Pulse Width 0.15ms vs 0.30ms in Electroconvulsive Therapy January 18, 2022 January 18, 2024
NCT06211140 Recruiting N/A Transcranial Alternating Current Stimulation (tACS) on Serotonin-1A Receptor in Depression January 31, 2024 May 31, 2025
NCT04972136 Recruiting N/A rTMS for Depression in Young Adults With Autism January 14, 2021 January 14, 2027
NCT05570812 Recruiting Phase 2 Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV March 3, 2023 January 31, 2028
NCT05842278 Recruiting N/A The Dosage Effect of pBFS Guided rTMS Treatment for MDD July 7, 2023 October 1, 2024
NCT05320107 Recruiting Phase 1 The Effect of Ketamine on Aesthetics and Role for Antidepressant Effects June 1, 2022 February 28, 2025
NCT06011577 Recruiting Phase 3 Randomized, Double-Blind, Placebo-Controlled Trial of REL-1017 as Adjunctive Treatment for MDD August 17, 2023 December 2024
NCT05435820 Recruiting N/A Near-infrared Transcranial Laser Therapy in Subjects With Major Depressive Disorder: A Study of Dosing With Laser July 1, 2022 July 2024
NCT05598034 Recruiting N/A Evaluating tDCS Brain-stimulation in Depression Using MRI October 20, 2022 May 1, 2027
NCT05409794 Recruiting Basal Plasma Lithium Levels and Suicidal Events December 9, 2022 July 9, 2025
NCT03787290 Suspended Phase 2 Mild-Intensity Whole Body Hyperthermia (WBH) for Major Depressive Disorder December 1, 2025 March 1, 2028
NCT04825535 Suspended N/A Non-Inferiority RCT Comparing Online and On-Site CBT in MDDi April 2024 April 2025
NCT04311619 Suspended Phase 1 Does rTMS Induce Synaptic Plasticity? December 1, 2019 February 1, 2025
NCT01436175 Terminated Phase 3 SPD489 Adult Major Depressive Disorder (MDD) Open-label Safety and Tolerability Rollover Extension Study February 27, 2012 March 27, 2014
NCT02922725 Terminated Phase 4 Placebo-controlled Trial of 5-hydroxytryptophan and Creatine for SSRI or SNRI Augmentation in Treatment Resistant Depression in Females November 2016 May 2020
NCT03977675 Terminated Phase 1 The Role of HNKs in the Antidepressant Effect of Ketamine May 15, 2019 July 2, 2020
NCT00332670 Terminated Phase 2/Phase 3 Light Therapy for Elderly Depression January 2003 June 2007
NCT01921543 Terminated Phase 1/Phase 2 Deep Brain Stimulation in Treatment Refractory Depression January 2005 October 2013
NCT00659347 Terminated Phase 2 Efficacy and Safety of DOV 21,947 in the Treatment of Major Depressive Disorder March 2008 December 2008
NCT03228953 Terminated N/A Pharmacogenomic Testing in Major Depressive Disorder August 1, 2017 July 17, 2019
NCT03093025 Terminated Phase 2 A Study to Evaluate the Safety and Efficacy of TS-121 as an Adjunctive Treatment for Major Depressive Disorder July 3, 2017 December 4, 2018
NCT03254342 Terminated MRS and Medication Response: A Pilot Study August 6, 2013 August 31, 2020
NCT00642694 Terminated Phase 3 Time to Remission of Depressive Symptoms With Combined SSRI and Ramelteon May 2007 May 2010
NCT00204152 Terminated Phase 3 Treatment for Chronic Depression June 2004 June 2006
NCT04007367 Terminated Phase 3 A Study to Evaluate SAGE-217 for Prevention of Relapse in Adult Participants With Major Depressive Disorder August 6, 2019 January 6, 2020
NCT02422303 Terminated N/A Effects of Low Dose Ketamine Given at Induction of Anesthesia on Postoperative Mood in Patients With Depressive Symptoms December 2015 September 2016
NCT02415166 Terminated N/A Influenza Challenge in Mood Disorders July 2015 March 2016
NCT02661828 Terminated N/A Tapering Off Antidepressants January 2016 March 17, 2017
NCT02029963 Terminated N/A Can Magnetic Brain Stimulation Help Prevent Relapse in Depression? February 2014 November 10, 2021
NCT04353921 Terminated PSIL201 Long-term Follow-up Study: Psilocybin or Niacin / Major Depressive Disorder June 30, 2020 October 18, 2022
NCT02882711 Terminated Phase 2 The UTHealth Ketamine Project November 7, 2016 August 16, 2017
NCT03731728 Terminated N/A Group CBT and Exercise in Management of Depression April 15, 2019 March 1, 2020
NCT04618263 Terminated Phase 1 Safety and Tolerability of Single and Multiple Ascending Doses of GATE-101 in Normal Human Volunteers October 26, 2020 August 13, 2021
NCT02802293 Terminated N/A Treatment of Depression With Connectivity Guided Robotically Delivered rTMS August 17, 2017 March 23, 2021
NCT01837797 Terminated Phase 3 Efficacy and Safety of Brexpiprazole as Adjunctive Treatment in Elderly Patients With Major Depressive Disorder With an Inadequate Response to Antidepressant Treatment April 2013 May 2014
NCT04317495 Terminated N/A Augmenting rTMS With Cognitive Control Training in Major Depressive Disorder August 27, 2019 April 1, 2021
NCT01890083 Terminated Phase 2/Phase 3 A Health Intervention to Prevent Depression Hepatitis C Patients June 2013 October 2015
NCT01465165 Terminated Use of Multiple Brain Imaging Modalities (PET and MRS) to Identify Metabolic Abnormalities in Major Depression May 15, 2011 June 24, 2012
NCT01426516 Terminated N/A Pharmacogenomics for Antidepressant Guidance and Education 1 (PAGE-1_AG1) September 2011 June 2014
NCT04714164 Terminated N/A Cognitive Behavioral Therapy Group for Older Adults Delivered by Telethealth February 18, 2021 September 15, 2023
NCT03487198 Terminated Phase 3 The Safety and Efficacy of Brexpiprazole as Adjunctive Therapy in the Treatment of Major Depressive Disorder May 30, 2018 May 30, 2019
NCT03079297 Terminated Phase 2 Rapid Antidepressant Effects of Leucine March 9, 2017 October 4, 2021
NCT01260649 Terminated Phase 4 N-methyl-D-aspartate Antagonist (Ketamine) Augmentation of Electroconvulsive Treatment for Severe Major Depression November 1, 2010 November 1, 2012
NCT05461599 Terminated N/A Digital Therapeutic for Adolescent Depressive Symptoms in Cardiology and Gastroenterology August 25, 2022 May 16, 2023
NCT02980484 Terminated Phase 2 fMRI-neuronavigated rTMS for the Treatment of Major Depression Associated With TBI August 2016 August 2017
NCT01145755 Terminated Phase 2 6-week Study Treatment to Evaluate the Safety and Effectiveness of AZD2066 in Patients With Major Depressive Disorder May 2010 November 2010
NCT05802966 Terminated Cognition in Mindfulness: Negativity and Depression June 24, 2019 March 28, 2023
NCT01804296 Terminated N/A rTMS for Depressed Teens: A Sham-Controlled Trial, Part 2 March 2013 September 2015
NCT03998748 Terminated N/A Electrophysiological Correlates of Cognition in Depression October 8, 2019 August 1, 2022
NCT02192099 Terminated Phase 2 Open Label Extension for GLYX13-C-202, NCT01684163 September 8, 2014 November 8, 2018
NCT02661061 Terminated Phase 1 Ketamine for Relapse Prevention in Recurrent Depressive Disorder December 2015 May 23, 2018
NCT02940769 Terminated N/A Neurobiological Effects of Light on MDD September 4, 2014 February 14, 2017
NCT00313417 Terminated Phase 4 Creatine as a New Therapeutic Strategy in Depression January 2007 December 2010
NCT03620253 Terminated Phase 3 Modafinil's Effects on Cognition in Remitted MDD October 15, 2018 August 6, 2019
NCT05086120 Terminated N/A A Remote Electronically Delivered Integrated Care Pathway: A Feasibility Study January 4, 2023 January 23, 2024
NCT02660528 Terminated Phase 2 Tocilizumab Augmentation in Treatment-Refractory Major Depressive Disorder April 2016 June 2020
NCT00182533 Terminated Phase 4 Sertraline in Generalized Social Phobia With Co-Occurring Anxiety and Mood Disorders July 2002 January 2018
NCT01787240 Terminated Phase 4 Neurobiological Bases of Placebo Response in Major Depressive Disorder November 2012 August 2016
NCT04697693 Terminated Phase 4 Antidepressant Response in Older Adults With Comorbid PTSD and MDD March 3, 2021 May 20, 2021
NCT01226238 Terminated N/A Online Self-help for Depressed Patients Awaiting Psychotherapy October 2010
NCT05193318 Terminated Phase 2 KAP for Depression in Abstinent Opioid Users January 13, 2022 March 20, 2023
NCT01804270 Terminated N/A rTMS for Depressed Teens: A Sham-Controlled Trial, Part 1 April 2013 September 2015
NCT00715559 Terminated N/A Cysteamine Therapy for Major Depressive Disorder July 2008 May 2009
NCT01957501 Terminated Detecting Depression and Bipolar Disorder in Adolescents Using a Biomarker Panel July 2013 March 2016
NCT01211756 Terminated N/A Oxytocin Add-on for Stable Depressed Patients October 2010 December 2015
NCT01310140 Terminated Risks for Insulin Resistance and Metabolic Syndrome Between Major Depressive Disorder (MDD) or MDD With Psychotic Features January 2011 September 2012
NCT00400088 Terminated Phase 3 Lithium Versus Paroxetine in Patients With Major Depression Who Have a Family History of Bipolar Disorder or Suicide June 2007 January 2013
NCT05273983 Terminated N/A Pilot Study of a Brief Behavioural Activation Intervention for Depressed Patients in Primary Care January 14, 2022 February 23, 2023
NCT01162382 Terminated N/A Repetitive Transcranial Magnetic Stimulation for Treating Depression: A Functional Magnetic Resonance Imaging Study January 2010 September 2013
NCT03537547 Terminated Phase 4 Combinatorial Pharmacogenomics Testing in Treatment-Naïve Major Depressive Disorder May 4, 2018 August 19, 2019
NCT01856127 Terminated Phase 4 Does Vilazodone Help With Antidepressant-associated Sexual Dysfunction? January 2013 June 2016
NCT01703039 Terminated Phase 2 Riluzole Augmentation Pilot in Depression (RAPID) Trial January 2013 June 2018
NCT03281044 Terminated Phase 2 Fecal Microbiota Transplantation in Depression October 24, 2018 March 16, 2020
NCT01741142 Terminated Phase 2 Efficacy and Safety Study of ABT-436 in Major Depressive Disorder January 2012 August 2015
NCT03643159 Terminated Phase 4 A Trial to Measure the Difference in All-cause Hospitalizations for Participants Who Are Using Abilify MyCite Versus Virtual Matched Controls in Adults With Schizophrenia, Bipolar 1 Disorder, and Major Depressive Disorder June 28, 2018 October 17, 2018
NCT02095639 Terminated Inflammation and Electroconvulsive Therapy August 2012 May 2017
NCT03999736 Terminated Phase 1/Phase 2 Biomarkers of Response to Treatment With Frontal Cortex Stimulation for Anxious Depression February 13, 2020 February 9, 2021
NCT01031810 Terminated Phase 4 PET Biomarkers in Treatment Resistant Depression November 2009 March 2013
NCT03523767 Terminated Phase 1 Effect of Systemic Inflammation on Emotion and Cognition in Patients With Mood Disorder - A Vaccine Study February 7, 2018 February 7, 2020
NCT03889756 Terminated Phase 2/Phase 3 Ketamine for Severe Adolescent Depression: Intermediate-term Safety and Efficacy July 17, 2019 January 5, 2023
NCT01288079 Terminated Phase 2 A Study to Assess the Safety and Effect of TC-5214 in Patients With Major Depressive Disorder. February 2011 August 2012
NCT00926835 Terminated Phase 4 Effect of Antidepressants on the Treatment for Korean Major Depressive Disorder Patients May 2009 July 2015
NCT03222752 Terminated N/A Efficacy of Cranial Electrotherapy Stimulation (CES) for the Treatment of Major Depressive Disorder June 5, 2017 April 25, 2023
NCT04632498 Terminated N/A Investigating Biological Markers, Targets, and Intervention for Mood Disorders October 26, 2021 April 3, 2024
NCT02943096 Terminated N/A Flavanol Augmentation for Antidepressant Non-Responsive Late Life Depression November 2016 February 6, 2018
NCT01337609 Terminated Phase 4 Study of Probiotic GanedenBC30 for Irritable Bowel Syndrome and Major Depressive Disorder June 2011 February 2012
NCT02176824 Terminated N/A Chronotherapy Randomized Controlled Trial June 1, 2014 April 7, 2016
NCT01579942 Terminated Potential Use Of Brain Network Activation Analysis to Diagnose Major Depression April 2012
NCT01650740 Terminated N/A Study of Placebo Without Deception Versus Standard Antidepressant for Major Depressive Disorder August 2012 November 2014
NCT01957410 Terminated Phase 2 A Study to Investigate Evoked Potentials as Markers of Ketamine-induced Cortical Plasticity in Patients With Major Depressive Disorder February 2014 September 2015
NCT01156415 Terminated Phase 3 Open-label Long Term (52 Weeks) Safety and Tolerability of Agomelatine Sublingual Tablets in Major Depressive Disorder (MDD) June 2010 October 2011
NCT03152409 Terminated Phase 2 Salicylic Augmentation in Depression November 15, 2018 February 16, 2021
NCT02236702 Terminated Kappa Opioid Receptor Imaging in Depression (KOR Depression) August 2014 February 2016
NCT03761030 Terminated Phase 4 L-DOPA vs. Placebo for Depression and Psychomotor Slowing in Older Adults January 9, 2019 September 8, 2021
NCT00766870 Terminated Phase 2 Efficacy and Safety of Lu AA34893 in Patients With Major Depressive Disorder September 2008 February 2009
NCT03771664 Terminated Phase 3 A Study to Evaluate the Safety, Tolerability, and Efficacy of SAGE-217 Compared to Placebo in Adult Participants With Comorbid Major Depressive Disorder (MDD) and Insomnia February 4, 2019 January 17, 2020
NCT00868374 Terminated Phase 3 Quetiapine Extended Release (XR) Treatment of Major Depressive Disorder With Comorbid Generalized Anxiety Disorder June 2008 October 2011
NCT01769859 Terminated Systematic Genetic Analysis of Phenomenology and Treatment Response in Mood Disorders January 2013 May 2016
NCT01098240 Terminated Phase 2 A Study Of The Efficacy And Safety Of CP-601,927 Augmentation Of Antidepressant Therapy In Major Depression June 14, 2010 September 12, 2011
NCT02021149 Terminated N/A Enhancing Psychotherapy for Mood Disorders With Whole Body Hyperthermia July 2014 November 2015
NCT01944969 Terminated Phase 3 Long-term Safety and Tolerability Study of Brexpiprazole as Adjunctive Treatment in Patients With Major Depressive Disorder October 2013 May 2014
NCT01353963 Terminated Desvenlafaxine Succinate (Pristiq): Postmarketing Surveillance Study Among Filipino Patients March 2012 August 2012
NCT01478113 Terminated N/A Stimulant Enhancement of Well-Being Therapy for Depression February 2012 July 2015
NCT01740726 Terminated N/A Comparison of Behavioral Activation and Antidepressant Medication in the Treatment of Adolescents With Depression January 2013 March 2014
NCT00763594 Terminated Phase 2 Linköping University Relational and Interpersonal Psychotherapy Project September 2008 December 2017
NCT04972474 Unknown status N/A Exploring Engagement With Remote Symptom Tracking for Depression (RADAR: Engage) April 7, 2021 September 2021
NCT01997580 Unknown status Phase 4 Electrophysiologic Parameters and Biomarkers Predicting Treatment Response in Patients With Major Depressive Disorder July 2013 December 2018
NCT01706731 Unknown status N/A Effectiveness of Buddhist Monks in Providing Cognitive Behavior Therapy October 2012 October 2013
NCT00243425 Unknown status N/A Patient-Centered Depression Care for African Americans March 2004 March 2007
NCT03088657 Unknown status Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study September 2015 September 2022
NCT02549547 Unknown status N/A Jump Step - A Participatory Approach to Physical Activity & Mental Wellness August 2015 June 2017
NCT03009448 Unknown status The Experience of Older Adults Facing Depression for the First Time in Old Age March 2017
NCT04842929 Unknown status N/A Magnetic Randomized Trial in Elderly Depressed January 16, 2019 December 20, 2022
NCT03881449 Unknown status Phase 4 DIMES - DIgital MEdicine Study for Adults With Schizophrenia, Bipolar I Disorder, or Major Depression Currently Using Aripiprazole April 4, 2019 November 2021
NCT04780152 Unknown status Phase 2/Phase 3 TDCS in Pediatric and Teenage Patients With Major Depressive Disorder During COVID-19 Pandemic October 2021 September 2022
NCT01450150 Unknown status Phase 2/Phase 3 Transcranial Direct Current Stimulation as an Augmenting Intervention for Major Depression January 2016 October 2018
NCT04784494 Unknown status N/A MST for Parkinson's Disease September 20, 2021 December 2023
NCT03899194 Unknown status N/A Study on the Effect of PRKCB1 Modulating Inflammatory Factors and the Role for Developing Major Depressive Disorder January 1, 2019 December 31, 2021
NCT05236959 Unknown status N/A Mindfulness-Based Cognitive Therapy for Depressed IAPT Non-Responders January 1, 2021 December 31, 2022
NCT04104698 Unknown status Cognitive, Psychological and Electrophysiological Attributes to Suicide Among Depressed Patients October 1, 2019 August 1, 2020
NCT01764867 Unknown status Phase 4 Algorithm Guided Treatment Strategies for Major Depressive Disorder June 2012 December 2014
NCT03703414 Unknown status Characterization of Microbial, Immune and Epigenetic Biomarkers for Major Depressive Disorder and ECT Treatment November 1, 2018 October 31, 2019
NCT01198561 Unknown status Repetitive Transcranial Magnetic Stimulation(rTMS) in the Treatment of Depression February 2006 December 2016
NCT01460212 Unknown status Phase 4 Magnetic Resonance Imaging Study of Cognitive-Behavior Therapy for Major Depressive Disorder December 2011 October 2015
NCT04425278 Unknown status N/A tDCS Intervention on Motivational Anhedonia of Major Depressive Disorder March 1, 2018 December 31, 2021
NCT03628027 Unknown status Phase 2 The Antidepressant Advisor Study August 1, 2018 July 2021
NCT01070134 Unknown status N/A Mindfulness-based Behavioural Therapy (MIBT) Versus Psychodynamic Therapy for Patients With Major Depressive Disorder in Psychotherapeutic Day Treatment. A Randomised Clinical Pilot Trial February 2010 August 2011
NCT03790085 Unknown status Early Phase 1 Identification of Multi-modal Bio-markers for Early Diagnosis and Treatment Prediction in Schizophrenia Individuals September 1, 2018 December 31, 2020
NCT04352621 Unknown status Phase 4 Study to Assess the Effects of Intranasal Ketamine Along With rTMS for Patients With Treatment-resistant Major Depressive Disorder (TRD) May 1, 2020 May 1, 2022
NCT02724735 Unknown status A Longitudinal Observational Cohort Study of NSI-189, With Out-Patients With Major Depressive Disorder August 2016 January 2018
NCT03138681 Unknown status Phase 2 Rapid Antidepressant Effects of ATP and Phosphocreatine May 3, 2017 April 30, 2019
NCT01743716 Unknown status Genetic and Neural Predictors of Adolescent Depression April 2013 December 2020
NCT00239954 Unknown status Phase 3 Escitalopram Combination Comparison Study for Adult Patients With Major Depressive Disorder March 2005
NCT05104918 Unknown status Phase 3 Vortioxetine as a Novel Anti-depressant With Improvement in Cognitive Abilities February 2022 June 2022
NCT02925325 Unknown status N/A Music Therapy for Major Depressive Disorder Residual Symptoms October 2016 June 2017
NCT02383693 Unknown status Phase 2/Phase 3 Maintenance rTMS for Treatment-resistant Depression (TRD): a One-year Double Blind Controlled Study January 2007 December 2015
NCT05006365 Unknown status N/A EffectsOfTranscranialPulseStimulationOnDepression-PilotRCT August 2, 2021 August 2, 2023
NCT03711045 Unknown status An Eye Tracking Study of Affective Disorder Patients With Suicide Risk September 1, 2018 December 31, 2019
NCT03122158 Unknown status Phase 4 Escitalopram in the Treatment of Adolescents With Major Depressive Disorder or Anxiety Disorders April 8, 2017 December 15, 2018
NCT00693849 Unknown status Phase 4 International Study to Predict Optimised Treatment - in Depression September 2008 December 2019
NCT03558256 Unknown status N/A The Study of Mindfulness-based Cognitive Therapy and Major Depressive Disorder May 16, 2016 December 31, 2018
NCT03062332 Unknown status The Gut Microbiota of Bipolar and Depression January 16, 2020 November 2022
NCT04641780 Unknown status "Brexpiprazole (Rexulti™) Safety and Efficacy Among Filipino Patients (RAISE) - A Post Marketing Surveillance Program" August 17, 2019 March 2024
NCT04509882 Unknown status Phase 2 Bear Bile Pill as add-on the Treatment of MDD October 30, 2020 March 31, 2022
NCT05217758 Unknown status Phase 2 RESET-medication Glucocorticoid Receptor (GR) Blockade as Disease Modifying Treatment for Depression With Childhood Trauma December 9, 2021 June 9, 2024
NCT02715128 Unknown status N/A Disorder-tailored Transcranial Direct Current Stimulation (tDCS) of the Prefrontal Cortex March 2016 January 2022
NCT04124276 Unknown status N/A Evaluation of Efficacy of Lycium Barbarum Polysaccharide in Patients With Major Depressive Disorder November 1, 2019 June 1, 2021
NCT03388177 Unknown status N/A Yoga for Young Women With Depression December 16, 2016 December 16, 2019
NCT04006834 Unknown status Hypersomnia in Major Depressive Disorder July 1, 2019 August 31, 2020
NCT02666989 Unknown status N/A Open-Label Placebo for the Treatment of Depression February 2016
NCT03623711 Unknown status Early Phase 1 A Prediction Study of Multiple Indexes of the Effect of Different Mechanisms of Antidepressants Treatment on Depression August 1, 2018 December 31, 2022
NCT00620789 Unknown status N/A Behavioral Insomnia Therapy For Those With Insomnia and Depression March 2008 January 2014
NCT03084042 Unknown status Emotional Brain Networks & Cognitive Functioning in Depression and Anxiety July 2016 June 2019
NCT05106868 Unknown status N/A Acupuncture for Patients With Major Depressive Disorder November 1, 2021 June 30, 2023
NCT02669030 Unknown status Phase 4 A Six Week, Randomized, Double-Blind Placebo-Controlled, Suvorexant Augmentation Study of Antidepressant Treatment of Major Depressive Disorder With Residual Insomnia March 1, 2017 December 2019
NCT02562677 Unknown status Phase 1/Phase 2 TNS for Treating Major Depressive Disorder in the Elderly October 2015 February 2016
NCT00888862 Unknown status Phase 3 Desvenlafaxine Succinate (DVS) for Major Depressive Disorder (MDD) in Midlife Men and Women June 2009 October 2012
NCT01699490 Unknown status Phase 4 Role of Inflammation Factors and Insulin Resistance in Major Depressive Disorder August 2012 July 2015
NCT04528628 Unknown status N/A Optimization of Diagnosis and Treatment of Depression Based on Multidimensional Clinical Assessment Classification October 2020 September 2022
NCT03548545 Unknown status N/A tDCS as add-on Treatment to Cognitive-Behavior Therapy in People With MDD March 28, 2018 December 31, 2020
NCT03432221 Unknown status Switching From SSRI to Desvenlafaxine on Cognitive Functioning April 3, 2018 June 3, 2019
NCT01682785 Unknown status Incidence of Metabolic Syndrome and Thyroid Dysfunction in Patients With Major Depressive Disorder September 2012
NCT01488266 Unknown status N/A Aripiprazole Augmentation Versus Switching to Different Class of Antidepressants in Major Depressive Disorder November 2011 March 2013
NCT04208932 Unknown status A Kynurenine Pathway-based Molecular Imaging Study of Individualized Diagnosis and Treatment for Major Depressive Disorder August 12, 2019 December 31, 2021
NCT05148169 Unknown status Phase 4 A Pilot Study on Effect of add-on Sulforaphane to SSRIs and Application of Niacin Skin Flush Response Test in Major Depressive Disorder January 1, 2020 December 31, 2022
NCT05028738 Unknown status N/A Patient-oriented Randomized Pragmatic Feasibility Trial With rTMS in Depression and Anxiety October 11, 2021 August 2022
NCT03295708 Unknown status N/A Fish Oil as Adjunct Treatment for Major Depressive Disorder October 1, 2017 April 1, 2020
NCT04430556 Unknown status N/A Brain Hippocampal Volume Relationship With Anxious Symptoms in Major Depressive Patients July 1, 2018 December 2020
NCT04138290 Unknown status Phase 4 Post Marketing Study for the Evaluation of Predictix Antidepressant Clinician Software Support Tool in Prescribing Antidepressant Medication/s for the Treatment of Patients Suffering From Major Depressive Disorder December 2019 December 2020
NCT04843462 Unknown status N/A Add-on Therapy With Edupression.Com® on Therapy Resistant Depressive Patients Treated With Nasal Esketamine Spray April 29, 2021 April 14, 2023
NCT01418638 Unknown status The Metabolic Effects of Antidepressants in Patients Diagnosed With Major Depressive Disorder May 2012
NCT04000022 Unknown status Repetitive Transcranial Magnetic Stimulation in Pharmaco-naïve Patients With Major Depression January 1, 2019 May 1, 2024
NCT02048423 Unknown status Phase 2/Phase 3 An Open Prospective Trial of IV Ketamine in Suicidal Adolescents June 2013 June 2015
NCT03187093 Unknown status Phase 4 Cognitive Dysfunction in MDD Patients October 2016 April 2019
NCT00442481 Unknown status Phase 4 Escitalopram and Sleep Architecture in Patients With Major Depressive Disorder February 2007
NCT03175068 Unknown status N/A Transdiagnostic Brain-Behavior Profiling to Enhance Cognitive Behavioral Therapy Response July 5, 2017 June 30, 2022
NCT04447430 Unknown status N/A Light Therapy to Improve Symptoms in Pregnant Women With Major Depressive Disorder June 12, 2020 December 30, 2021
NCT01204086 Unknown status Phase 4 Pharmacogenomics Studies of Antidepressants March 2007 February 2011
NCT04037111 Unknown status N/A Clinical Study of Escitalopram Oxalate Combined With taVNS in Depression and Concomitant Inflammatory Symptoms July 23, 2019 December 2021
NCT04183946 Unknown status N/A Willkommen Mutterglück: Online CBT for Pregnant and Postpartum Women With Depression and Anxiety June 2020 January 2024
NCT04593563 Unknown status Phase 2 The Safety and Efficacy of Psilocybin in Cancer Patients With Major Depressive Disorder September 1, 2020 October 2023
NCT04253678 Unknown status Vortioxetine for Cancer Patients With Depression: An Observational Study December 12, 2019 July 2020
NCT03329287 Unknown status N/A Simplified Cognitive Behavioral Therapy for Generalized Anxiety Disorder and Depression July 1, 2017 June 30, 2018
NCT02934035 Unknown status Early Improvement in Individual Symptoms and Response to Antidepressants in Patients With Major Depressive Disorder September 2016 September 2017
NCT04469608 Unknown status N/A Establishing TCM Daycare Model and Teaching Mechanism of Depression Patients May 11, 2020 December 31, 2021
NCT01671124 Unknown status The Study of Antidepressant Properties and Safety of Fer-01(Soline®) on the Patients With Depression September 2012 November 2013
NCT03786731 Unknown status N/A A Transdiagnostic Sleep and Circadian Treatment for Major Depressive Disorder January 1, 2019 June 2021
NCT02711215 Unknown status Phase 4 Patient Stratification and Treatment Response Prediction in Neuropharmacotherapy Using Hybrid Positron Emmission Tomography/Magnetic Resconance Imaging (PET/MR) May 2015 January 2020
NCT05499117 Unknown status N/A Efficacy and Safety of Light Therapy in the Treatment of Non-seasonal Depressive Disorder in Chinese Population February 1, 2022 July 31, 2023
NCT02728557 Unknown status N/A Supportive and Supportive-Expressive Treatment for Depression March 2016 February 17, 2023
NCT03606850 Unknown status N/A Transcranial Magnetic Stimulation Study of Cortical Excitability as Marker of Antidepressant Response: EXCIPSY Study July 30, 2018 August 30, 2020
NCT02037503 Unknown status Phase 3 The Effect of Ketamine on Mechanises Underlying Suicidal Ideation and Drug-resistant Major Depression January 2014 May 2020
NCT00889369 Unknown status Phase 4 Duloxetine for Major Depression in Peri-/Postmenopausal Women May 2009 June 2012
NCT04206969 Unknown status N/A Assessment of Transcultural Psychotherapy in Child Major Depressive Disorder April 2020 October 2023
NCT02330679 Unknown status Phase 4 Prediction of Antidepressant Treatment Response Using Machine Learning Classification Analysis December 2014 December 2016
NCT03237078 Unknown status N/A Lactobacillus Plantarum PS128 in Patients With Major Depressive Disorder and High Level of Inflammation August 1, 2017 July 31, 2019
NCT03666390 Unknown status N/A Using a Low Dose of Ketamine vs. Active Placebo in Treating Severe Depression and Suicide September 10, 2018 December 31, 2021
NCT04031157 Unknown status N/A Controlled Study to Evaluate the Safety and Efficacy of the Predictix Antidepressant Clinician Support Tool January 1, 2018 December 2020
NCT05149352 Unknown status N/A RESET-psychotherapy: the Effectiveness of Trauma-focused Therapy in Patients With Depression and Childhood Trauma November 10, 2021 March 1, 2024
NCT04210973 Unknown status Phase 3 Comparison of Anyu Peibo With Placebo in Treatment of MDD in China January 23, 2020 May 2021
NCT01357967 Unknown status Phase 4 The Effect of Quetiapine XR in Depressive Patients Showing Aberrant N100 Amplitude Slope May 2011 April 2013
NCT02294305 Unknown status Phase 4 Vortioxetine Versus Placebo in Major Depressive Disorder Comorbid With Social Anxiety Disorder December 2014 November 2016
NCT04986124 Unknown status Quality of Life in Chinese Working and School Age Population With MDD April 1, 2021 August 30, 2021
NCT02120729 Unknown status N/A Pharmacogenetic Decision Support IT System for Psychiatric Hospitalization: RCT March 2014 October 2019
NCT04602715 Unknown status Phase 2 The Safety, Efficacy, and Tolerability of Microbial Ecosystem Therapeutic-2 in People With Major Depression April 1, 2021 June 2021
NCT04399070 Unknown status N/A The Effect of S-ketamine for Patients Undergoing Electroconvulsive Therapy (ECT) August 1, 2020 January 31, 2021
NCT01473615 Unknown status N/A Mindfulness Based Cognitive Therapy for Chronic Pain and Comorbid Unipolar Depression November 2011 June 2014
NCT02586688 Unknown status N/A Safety and Effectiveness of NeuroStar® Transcranial Magnetic Stimulation (TMS) Therapy in Depressed Adolescents October 2015 December 2018
NCT03230682 Unknown status Eealy Improvement Predicts Antidepressants Response in Adults With Major Depression Disorder July 25, 2017 July 11, 2018
NCT03811860 Unknown status N/A Lithium Therapeutic Drug Monitoring; Once Daily Vs Twice Daily Dosing and the Impact of Kidney Function February 6, 2019 December 2019
NCT01369290 Unknown status Electroencephalography (EEG) Signal Processing October 2009 October 2013
NCT01979289 Unknown status N/A Computerized Cognitive Remediation for Geriatric Depression August 2012 July 2017
NCT03191994 Unknown status N/A Impact of an Eight Week Exercise Intervention in Treating Major Depressive Disorder January 2, 2014 June 2018
NCT00464048 Unknown status N/A A Controlled Study to Assess the Effectiveness of Aerobic Exercise as an Augmentation Therapy for Inpatients With Major Depressive Disorder May 2007 May 2009
NCT00939718 Unknown status N/A Comparison of Vitamin B12 Supplementation to Selective Serotonin Reuptake Inhibitor (SSRI) Versus SSRI Antidepressant Treatment Alone April 2009 September 2010
NCT02983838 Unknown status Research on Pathophysiology and Treatment in Depression Using Brain Derived Neurotrophic Factor and Amyloid Neuroimaging April 2016 December 2017
NCT01977378 Unknown status Phase 2/Phase 3 A Study of Sustained-Release Desvenlafaxine Hydrochloride for the Treatment of Major Depressive Disorder October 2013
NCT00628914 Unknown status Phase 4 Brain Mechanisms and Targeting Insomnia in Major Depression May 2008 February 2010
NCT02348827 Unknown status N/A Family Psychoeducation for Major Depressive Disorder January 2015 September 2017
NCT03721900 Unknown status Phase 1 Ketamine for Major Depressive Disorder December 28, 2018 June 6, 2019
NCT04124744 Unknown status N/A A Pilot Randomised Controlled Trial of a Health Champion Intervention April 2, 2020 May 30, 2022
NCT00335205 Unknown status Phase 4 A Placebo Controlled Trial of the Dopamine D-2 Receptor Agonist Ropinirole in Treatment of 60 Patients With Refractory Bipolar Depression. April 2003
NCT02268487 Unknown status Phase 4 Integral Assessment in Unipolar Depression January 2014 January 2017
NCT04347577 Unknown status Intestinal Flora and Major Depressive Disorders April 10, 2020 April 1, 2023
NCT04199845 Unknown status N/A 8-week of PS128 RCT in Patients With Major Depressive Disorder August 28, 2019 July 2022
NCT02285608 Unknown status N/A Partnership in Medication Management (PIMM) in Patients With Mood Disorders January 2015 May 2017
NCT00853346 Unknown status N/A Psychosocial Treatment of Depression in Parkinson's Disease April 2007 April 2013
NCT04971291 Unknown status Phase 2 An Evaluation of AXS-05 for the Treatment of TRD in Treatment-Adherent Patients April 14, 2021 July 2021
NCT03403881 Unknown status N/A Movement for Depression - An RCT Assessing the Effects of Physical Activity Promotion for People With MDD March 2016 May 2019
NCT01239888 Unknown status Phase 1 Oxytocin and Tibolone Adjuncts in Treatment Resistant Depression - A Pilot Study January 2012
NCT00433238 Unknown status Phase 1 Screening for Mental Health Concerns for at-Risk Community Living Chinese Seniors March 2007
NCT04609267 Unknown status N/A Interactive Voice-Based Administration of the PHQ-9 November 3, 2020 July 31, 2021
NCT02695472 Unknown status Phase 2 Study of NSI-189 for Major Depressive Disorder March 2016 December 2017
NCT04531423 Unknown status N/A PKC as Serum Biomarkers for Depression October 1, 2020 September 30, 2022
NCT04209166 Unknown status N/A A Study of Individualized Diagnosis and Treatment for Major Depressive Disorder With Atypical Features August 12, 2019 October 31, 2022
NCT05145270 Unknown status Phase 4 A Comparative Study on Efficacy and Safety of add-on Sulforaphane or rTMS to Escitalopram for Major Depressive Disorder With Poor Response to Initial Treatment November 30, 2019 November 30, 2022
NCT01573741 Unknown status Phase 1/Phase 2 Study of Ketamine as an Antidepressant in Major Depressive Disorder February 2012 February 2013
NCT04847245 Unknown status N/A Esketamine Adjuvant Therapy for Patients With Chronic Visceral Pain Comorbid Major Depressive Disorder May 1, 2021 March 1, 2023
NCT02238730 Withdrawn N/A Ultrabrief Right Unilateral and Brief Pulse Bitemporal Electroconvulsive Therapy September 2014 February 15, 2017
NCT00294944 Withdrawn Phase 3 The Effectiveness of Idazoxan in Treating TRD
NCT01423240 Withdrawn Phase 3 Major Depressive Disorder With Mixed Features January 2012 December 2012
NCT01733654 Withdrawn Phase 2 Investigate Efficacy & Safety of RO4995819 vs. Placebo as Adjunct Tx in Patients w/Major Depressive Disorder September 2012 May 2014
NCT04317001 Withdrawn Phase 3 Treatment for Cognitive Impairment in Depression December 1, 2018 November 30, 2024
NCT01942187 Withdrawn Phase 4 A Comparison of Medication Augmentation and PST in the Treatment of Depression in Older Adults August 2013 December 2015
NCT05315401 Withdrawn Phase 2 The Efficacy of Probiotic Compared With Placebo Commitment Therapy for Treatment of Major Depressive Disorder October 1, 2021 December 31, 2022
NCT04388202 Withdrawn Phase 4 Leveraging EEG for Antidepressant Prediction With Sertraline and Escitalopram October 15, 2020 May 30, 2023
NCT01752608 Withdrawn N/A Efficacy of Electronic Cognitive Behavioral Therapy Application to Treat Major Depressive Disorder October 2012 May 2015
NCT00993629 Withdrawn Phase 2 Adjunctive Pregnenolone in Post-Traumatic Stress Disorder (PTSD) and Depression in Operations Enduring Freedom and Iraqi Freedom (OEF/OIF) Veterans January 2010 May 2010
NCT03202095 Withdrawn Phase 4 Creatine for Treatment of Depression Associated With Type 2 Diabetes August 1, 2017 June 10, 2024
NCT05601648 Withdrawn Phase 2 PET Synaptogenesis After Psilocybin In DEpression Recovery July 1, 2023 July 1, 2025
NCT04887350 Withdrawn Phase 1 SSIPP vs. PST vs. WLC August 9, 2021 April 9, 2022
NCT01189318 Withdrawn Phase 2 Effects of Seroquel XR on Sleep Architecture in Patients With Major Depressive Disorder March 2012 February 2014
NCT01438242 Withdrawn N/A An Open Label Study of the Genecept™ Assay in Treatment Resistant Depression January 2015 January 2016
NCT03051945 Withdrawn Phase 3 Endogenous Opioid Modulation by Ketamine August 2019 August 1, 2019
NCT00988663 Withdrawn N/A The Impact of Memantine on Electroconvulsive Therapy (ECT): Will it Improve Response and Protect Against Cognitive Problems? November 2009 November 2009
NCT02024620 Withdrawn N/A Mobile Apps for the Treatment of Depression March 2014 October 2014
NCT04423471 Withdrawn Neuroinflammation, Affective and Cognitive Symptoms in Major Depression and Psoriasis February 1, 2021 December 2022
NCT00963196 Withdrawn N/A Study of Supplementation of Antidepressants With Fish Oil to Improve Time to Clinical Response September 2009 May 2010
NCT01583998 Withdrawn N/A Electronic-Measurement Based Care for Major Depressive Disorder June 2011 December 2016
NCT00617045 Withdrawn N/A Duloxetine for the Treatment of Postpartum Depression July 2007 May 2013
NCT03833063 Withdrawn Phase 1 Glabellar Botulinum Toxin Injections for the Treatment of Geriatric Depression May 1, 2019 March 31, 2020
NCT04217837 Withdrawn Treatment of Major Depressive Disorder in the UK Using TMS Therapy March 2020 February 2022
NCT02454426 Withdrawn Early Phase 1 Vortioxetine in Patients With Major Depressive Disorder and Coronary Artery Disease April 2016 June 2016
NCT05427981 Withdrawn Phase 3 Anti-suicidal Effects of Buprenorphine In Depressed Individuals October 10, 2022 January 14, 2024
NCT05921929 Withdrawn Phase 1 First-In-Human (FIH), Single Ascending Dose (SAD) Study of FluoroEthylNorMemantine (FENM) May 2, 2024 May 2, 2024
NCT00984087 Withdrawn Phase 2 rTMS for Adolescents and Young Adults October 2009 October 2011
NCT05594667 Withdrawn Phase 2 Effect of SSRIs on Response to Psilocybin Therapy January 1, 2023 March 14, 2023
NCT04924257 Withdrawn Phase 3 ECT vs. Esketamine July 28, 2021 April 2024
NCT00878748 Withdrawn Phase 4 Study Evaluating Effexor XR in Chinese Subjects With Major Depressive Disorder April 2009 October 2011
NCT01613820 Withdrawn N/A Ketamine and Scopolamine Infusions for Treatment-resistant Major Depressive Disorder September 2015 February 2017
NCT03068247 Withdrawn Phase 3 Neurobiology of Treatment Responses in MDD November 2021 May 2023
NCT02028026 Withdrawn Phase 4 The Effects of Vilazodone on Glutamate in the Anterior Cingulate Cortex in Anxious Unipolar Depressives April 2013 April 2015
NCT05134103 Withdrawn N/A Mindbeacon Therapist Assisted Internet Delivered CBT for Depression November 1, 2021 November 18, 2021
NCT03769350 Withdrawn N/A Waitlist-Control Trial of Smartphone CBT for Major Depressive Disorder (MDD) July 1, 2019 June 1, 2022
NCT04032015 Withdrawn N/A rTMS Study in Depression to Evaluate the Relationship Between Brain Plasticity and Clinical Outcome January 1, 2020 June 1, 2023
NCT01506206 Withdrawn ON/OFF Stimulation and Impulsivity in Patients With Deep Brain Stimulators February 2012 January 10, 2024
NCT04388189 Withdrawn Phase 4 Leveraging EEG for Antidepressant Prediction With Duloxetine and Bupropion October 15, 2020 May 30, 2023
NCT01175616 Withdrawn Phase 4 Creatine Augmentation in Veterans With SSRI-Resistant Major Depression September 2012 April 2014
NCT03580967 Withdrawn Phase 4 Vortioxetine Monotherapy for Major Depressive Disorder in Type 2 Diabetes July 1, 2019 July 1, 2021
NCT00262665 Withdrawn Phase 2 Randomized, Placebo-controlled Trial of an AMPAkine in Major Depressive Disorder March 2005 March 2005
NCT03842345 Withdrawn DELPhI Evaluation of Psychiatric Conditions March 2020 February 2021
Disase is a (Disease Ontology)
DOID:1596
Cross Reference ID (Disease Ontology)
EFO:0003761
Cross Reference ID (Disease Ontology)
ICD10CM:F32
Cross Reference ID (Disease Ontology)
ICD10CM:F33.9
Cross Reference ID (Disease Ontology)
ICD9CM:296.2
Cross Reference ID (Disease Ontology)
ICD9CM:296.3
Cross Reference ID (Disease Ontology)
MIM:608520
Cross Reference ID (Disease Ontology)
MIM:608691
Cross Reference ID (Disease Ontology)
NCI:C34796
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:268621008
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:36923009
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0024517
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0154409
Exact Synonym (Disease Ontology)
clinical depression
Exact Synonym (Disease Ontology)
major depression
Exact Synonym (Disease Ontology)
recurrent major depression
Exact Synonym (Disease Ontology)
single major depressive episode
Exact Synonym (Disease Ontology)
unipolar depression