acute promyelocytic leukemia (Cancer)
Information
- Disease name
- acute promyelocytic leukemia
- Disease ID
- DOID:0060318
- Description
- "An acute myeloid leukemia characterized by accumulation of promyelocytes in the bone marrow and by a translocation between chromosomes 15 and 17." [url:http\://en.wikipedia.org/wiki/Acute_promyelocytic_leukemia, url:http\://ghr.nlm.nih.gov/condition/acute-promyelocytic-leukemia]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT02688140 | Active, not recruiting | Phase 3 | Study for Patients With Newly Diagnosed, High-risk Acute Promyelocytic Leukemia | June 2016 | January 2025 |
| NCT00003861 | Active, not recruiting | Diagnostic Study of Patients With Acute Lymphoblastic Leukemia or Acute Promyelocytic Leukemia | April 1999 | ||
| NCT00413166 | Completed | Phase 2 | All-trans Retinoic Acid, and Arsenic +/- Idarubicin | December 2006 | February 2016 |
| NCT00465933 | Completed | Phase 4 | Treatment of Acute Promyelocytic Leukemia With All-Trans Retinoic Acid (ATRA) and Idarubicin (AIDA) | March 1999 | November 2007 |
| NCT00504764 | Completed | Phase 4 | Treatment of Relapsed Promyelocytic Leukemia With Arsenic Trioxide (ATO) | July 2007 | October 2014 |
| NCT00520208 | Completed | Phase 2 | Safety, Efficacy, & Pharmacokinetic Study of Tamibarotene to Treat Patients With Relapsed or Refractory APL | September 2007 | January 2013 |
| NCT01472107 | Completed | Study on Number and Outcome of Pregnancy in Acute Promielocitic Leukaemia (APL) Patients Treated With Chemotherapy | March 7, 2012 | June 14, 2019 | |
| NCT00408278 | Completed | Phase 4 | Treatment of Newly Diagnosed Patients With Acute Promyelocytic Leukemia (PETHEMA LPA 2005) | July 2005 | December 2013 |
| NCT01404949 | Completed | Phase 2 | Combined Tretinoin and Arsenic Trioxide for Patients With Newly Diagnosed Acute Promyelocytic Leukemia Followed by Risk-Adapted Postremission Therapy | July 2011 | February 1, 2021 |
| NCT01902329 | Completed | Phase 1 | A Safety Study of SGN-CD33A in AML Patients | July 2013 | December 8, 2017 |
| NCT01910623 | Completed | Long-Term Quality of Life in Patients With Acute Promyelocytic Leukemia | February 2013 | July 2014 | |
| NCT04793919 | Recruiting | Phase 2 | Treatment Study for Children and Adolescents With Acute Promyelocytic Leukemia | October 9, 2019 | October 10, 2027 |
| NCT04687176 | Recruiting | Phase 2 | Frontline Oral Arsenic Trioxide for APL | January 1, 2021 | June 30, 2026 |
| NCT04251754 | Recruiting | The Acute Promyelocytic Leukaemia Asian Consortium (APL-AC) Project | February 2, 2020 | June 2025 | |
| NCT03624270 | Recruiting | Phase 2 | Oral Arsenic Trioxide for Newly Diagnosed Acute Promyelocytic Leukaemia | August 15, 2018 | December 31, 2023 |
| NCT03751917 | Recruiting | Long-term Safety Study of Arsenic Trioxide in Newly Diagnosed, Low-to-intermediate Risk Acute Promyelocytic Leukemia | April 14, 2020 | December 2024 | |
| NCT05832320 | Recruiting | N/A | Optimum Induction Therapy of Low-risk APL | January 1, 2023 | December 31, 2024 |
| NCT04996030 | Suspended | Phase 1 | A Study for Oral SY-2101 for Participants With Acute Promyelocytic Leukemia | September 17, 2021 | April 2024 |
| NCT00985530 | Terminated | Phase 1 | Tamibarotene and Arsenic Trioxide for Relapsed Acute Promyelocytic Leukemia | October 2009 | May 2011 |
| NCT00852709 | Terminated | Phase 1 | Phase I Dose-Escalation Trial of Clofarabine Followed by Escalating Doses of Fractionated Cyclophosphamide in Children With Relapsed or Refractory Acute Leukemias | September 1, 2007 | November 20, 2009 |
| NCT00907582 | Terminated | Phase 2 | ASCT for Relapsed APL After Molecular Remission | June 2009 | May 2014 |
| NCT02899169 | Unknown status | Phase 3 | Treatment of Non-high-risk Acute Promyelocytic Leukemia (APL) With Realgar-Indigo Naturalis Formula (RIF) | September 1, 2016 | November 1, 2022 |
| NCT02991066 | Unknown status | Role of Microparticles in the Coagulopathy of Acute Promyelocytic Leukemia | October 2014 | December 2020 | |
| NCT03096496 | Unknown status | Long-term QoL in Acute Promyelocytic Leukemia Treated With ATO or Standard Chemotherapy | March 27, 2017 | January 2022 | |
| NCT01987297 | Unknown status | Phase 4 | Combined Retinoic Acid,Arsenic Trioxide and Chemo for Newly-diagnosed APL | June 2012 | December 31, 2020 |
| NCT02938858 | Unknown status | French Registry of First-line Treatment of Acute Promyelocytic Leukemia | October 2015 | October 2022 | |
| NCT01226303 | Unknown status | Phase 3 | Treatment Study for Children and Adolescents With Acute Promyelocitic Leukemia | January 2009 | December 2018 |
| NCT01064570 | Unknown status | Phase 2 | AIDA 2000 Guidelines | May 2000 | |
| NCT00675870 | Unknown status | Phase 2 | Study of NRX 195183 Therapy for Patients With Relapsed or Refractory Acute Promyelocytic Leukemia | April 2008 | |
| NCT00517712 | Unknown status | Phase 2/Phase 3 | Single Agent Arsenic Trioxide in the Treatment of Newly Diagnosed Acute Promyelocytic Leukemia | June 2004 | July 2009 |
| NCT00670150 | Withdrawn | Phase 2 | New Retinoid Agent Combined With Arsenic Trioxide for Untreated Acute Promyelocytic Leukemia | May 2010 | August 2010 |
- Disase is a (Disease Ontology)
- DOID:9119
- Cross Reference ID (Disease Ontology)
- GARD:538
- Cross Reference ID (Disease Ontology)
- ICD10CM:C92.4
- Cross Reference ID (Disease Ontology)
- MESH:D015473
- Cross Reference ID (Disease Ontology)
- MIM:612376
- Cross Reference ID (Disease Ontology)
- NCI:C3182
- Cross Reference ID (Disease Ontology)
- ORDO:520
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:28950004
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0023487
- Exact Synonym (Disease Ontology)
- acute myeloblastic leukaemia type 3
- Exact Synonym (Disease Ontology)
- acute myeloblastic leukemia type 3
- Exact Synonym (Disease Ontology)
- acute myeloid leukaemia M3
- Exact Synonym (Disease Ontology)
- acute myeloid leukemia M3
- Exact Synonym (Disease Ontology)
- acute promyelocytic leukaemia
- HPO Human Phenotype ID (Human Phenotype Ontology)
- HP:0004836
- OrphaNumber from OrphaNet (Orphanet)
- 520