multiple system atrophy
Information
- Disease name
- multiple system atrophy
- Disease ID
- DOID:4752
- Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT05109091 | Active, not recruiting | Phase 2 | Study of ATH434 in Participants With Multiple System Atrophy | July 1, 2022 | November 2024 |
| NCT04450992 | Active, not recruiting | TRACK-MSA: A Longitudinal Study to Define Outcome Measures in Multiple System Atrophy | June 17, 2020 | July 1, 2024 | |
| NCT06209515 | Active, not recruiting | Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register Study | January 1, 2022 | December 31, 2027 | |
| NCT02726711 | Active, not recruiting | Phase 1 | Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic | April 2016 | November 2024 |
| NCT05104476 | Active, not recruiting | Phase 2 | A Study of Lu AF82422 in Participants With Multiple System Atrophy | November 16, 2021 | May 14, 2026 |
| NCT04495582 | Active, not recruiting | Long-term Follow-up of Phase 1 Clinical Trial of CS10BR05(CS10BR05-MSA101) | August 28, 2018 | November 2024 | |
| NCT05699460 | Active, not recruiting | Pre-Gene Therapy Study in Parkinson's Disease and Multiple System Atrophy | September 29, 2022 | October 2025 | |
| NCT00750867 | Completed | Phase 2 | Treatment of Multiple System Atrophy Using Intravenous Immunoglobulins | June 2008 | December 2012 |
| NCT00911365 | Completed | Phase 2 | Trial of Autologous Mesenchymal Stem Cells in Patients With Multiple System Atrophy | May 2008 | June 2011 |
| NCT00977665 | Completed | Phase 2 | Clinical Trial to Assess Efficacy, Safety, and Tolerability of Rasagiline Mesylate 1 mg in Patients With Multiple System Atrophy of the Parkinsonian Subtype (MSA-P) | December 2009 | October 2011 |
| NCT01044693 | Completed | N/A | Nebivolol in the Supine Hypertension of Autonomic Failure | January 2010 | August 2014 |
| NCT01136213 | Completed | Investigation of the Serotoninergic System in Multiple System Atrophy: a Positron Emission Tomography (PET) Study | April 2010 | March 2016 | |
| NCT01146548 | Completed | Phase 2 | Fluoxetine in Multiple System Atrophy Patients | May 2008 | September 2011 |
| NCT01155492 | Completed | Increased Gut Permeability to Lipopolysaccharides (LPS) in Parkinson's Disease | September 2007 | February 2013 | |
| NCT06221644 | Completed | Synapse Alterations in MSA Patients | April 1, 2022 | November 25, 2022 | |
| NCT00103597 | Completed | Phase 1 | Efficacy of Therapeutic Interventions for Orthostatic Hypotension in Parkinson's Disease and Multiple System Atrophy | January 2005 | September 2005 |
| NCT00368199 | Completed | Transcranial Duplex Scanning and Single Photon Emission Computer Tomography (SPECT) in Parkinsonian Syndromes | September 1, 2006 | September 15, 2012 | |
| NCT00465790 | Completed | Research of Biomarkers in Parkinson Disease | October 2007 | June 2012 | |
| NCT00738062 | Completed | Phase 3 | Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) | January 2008 | December 2010 |
| NCT00742586 | Completed | Autonomic Failure Patients for RNA Blood Sampling | July 2008 | February 2009 | |
| NCT00743561 | Completed | N/A | Assessment of Ambulatory Polygraphy in the Detection of Sleep Apnea in Multiple System Atrophy (SAMSA) | June 2008 | January 2011 |
| NCT01316666 | Completed | Norepinephrine Transporter Blockade as a Pathological Biomarker in Neurogenic Orthostatic Hypotension | March 2011 | December 2016 | |
| NCT01353183 | Completed | N/A | Analysis of the Enteric Nervous System Using Colonic Biopsies | November 2010 | November 2012 |
| NCT01577992 | Completed | N/A | Evaluation of the Subjective and Objective Painful Threshold in Multiple System Atrophy Pain and Multiple System Atrophy | December 2011 | November 2013 |
| NCT02008721 | Completed | Phase 3 | Progression Rate of MSA Under EGCG Supplementation as Anti-Aggregation-Approach | January 2014 | December 2016 |
| NCT02064166 | Completed | Phase 2 | Treatment of Parkinson Disease and Multiple System Atrophy Using Intranasal Insulin. | February 2014 | September 2015 |
| NCT02071459 | Completed | Phase 2/Phase 3 | Efficacy of L-threo DOPS on Orthostatic Hypotension Symptoms and Other Non-motor Symptoms in Patients With MSA | January 21, 2014 | October 28, 2019 |
| NCT02132052 | Completed | Defining Phenotypes of Movement Disorders :Parkinson's Plus Disorders (PD), Essential Tremor (ET), Cortical Basal Degeneration (CBD), Multiple Systems Atrophy (MSA), Magnetoencephalography. | November 2013 | May 2014 | |
| NCT02185677 | Completed | Cognitive and Behavioral Dysexecutive Syndrome in Multiple System Atrophy | May 14, 2014 | June 26, 2015 | |
| NCT02270489 | Completed | Phase 1 | Study Assessing Safety and Therapeutic Activity of AFFITOPE® PD01A and PD03A in Patients With Early MSA | December 11, 2014 | April 18, 2017 |
| NCT02417415 | Completed | N/A | Local Heat Stress in Autonomic Failure Patients With Supine Hypertension | April 2015 | February 2021 |
| NCT02428816 | Completed | N/A | Evaluation of a Multimodal Neuroimaging Method for Diagnosis in Parkinsonian Syndromes | January 24, 2013 | July 28, 2016 |
| NCT02640339 | Completed | Retinal Abnormalities as Biomarker of Disease Progression and Early Diagnosis of Parkinson Disease | February 2016 | October 31, 2020 | |
| NCT02761707 | Completed | Biomarkers in Neural Disorders | June 2016 | July 16, 2019 | |
| NCT03076671 | Completed | N/A | More Than a Movement Disorder: Applying Palliative Care to Parkinson's Disease | March 1, 2017 | December 31, 2020 |
| NCT03120013 | Completed | N/A | Rehabilitative Trial With Cerebello-Spinal tDCS in Neurodegenerative Ataxia | February 6, 2017 | December 1, 2018 |
| NCT03265444 | Completed | Phase 1 | Safety and Tolerability of CS10BR05 Inj. in Subjects With Multiple System Atrophy | April 13, 2018 | December 5, 2019 |
| NCT03403309 | Completed | Phase 2 | Inosine 5'-Monophosphate to Raise of Serum Uric Acid Level in Patients With Multiple System Atrophy: a Multi-center, Randomized Controlled, Double Blind, Parallel Assigned Clinical Trial | May 2, 2018 | June 10, 2019 |
| NCT03452956 | Completed | Cognitive Impairement In Frontotemporal Dementia | July 1, 2003 | July 15, 2020 | |
| NCT03552484 | Completed | N/A | In-Home Care for Patients With PSP and Related Disorders | May 30, 2018 | December 31, 2020 |
| NCT03593512 | Completed | N/A | Deep Brain Stimulation for Autonomic and Gait Symptoms in Multiple System Atrophy | September 9, 2018 | August 8, 2022 |
| NCT03753763 | Completed | Phase 2 | Safinamide for Multiple System Atrophy (MSA) | October 29, 2019 | January 5, 2021 |
| NCT03952806 | Completed | Phase 3 | Study of BHV-3241 in Participants With Multiple System Atrophy | July 29, 2019 | June 30, 2022 |
| NCT04153110 | Completed | N/A | Cerebello-Spinal tDCS as Rehabilitative Intervention in Neurodegenerative Ataxia | December 1, 2018 | January 1, 2021 |
| NCT04184063 | Completed | Phase 2 | Study of NBMI Treatment in Patients With Atypical Parkinsons (PSP or MSA) | September 16, 2019 | June 30, 2021 |
| NCT04229173 | Completed | N/A | Natural History and Disease Progression Biomarkers of Multiple System Atrophy | May 26, 2020 | October 28, 2022 |
| NCT04287270 | Completed | N/A | Respiratoy Muscle Strength in Patients With Multiple System Atrophy | February 2, 2019 | February 26, 2021 |
| NCT04616456 | Completed | Early Phase 1 | Effect of Verdiperstat on Microglial Activation in Well-characterized MSA Patients | December 30, 2020 | January 30, 2022 |
| NCT04700722 | Completed | Synuclein-One Study | January 4, 2021 | November 8, 2023 | |
| NCT04858893 | Completed | Application of Machine Learning Method in Validation of Screening Cognitive Test for Parkinsonisms | January 1, 2017 | August 31, 2020 | |
| NCT05067192 | Completed | Optimization of Morphomer-based Alpha-synuclein PET Tracers | July 15, 2021 | September 1, 2021 | |
| NCT05453058 | Completed | Observational Study in Multiple System Atrophy | June 25, 2022 | March 12, 2024 | |
| NCT05621200 | Completed | N/A | Transcranial Alternating Current Stimulation (tACS) in Patients With Ataxia | January 28, 2021 | December 10, 2022 |
| NCT05638815 | Completed | An Observational Study of Parkinson's Disease and Other Synucleinopathies (EASE-PD) | November 23, 2021 | July 10, 2023 | |
| NCT00001549 | Completed | Diagnosis and Natural History Study of Patients With Neurological Conditions | October 1995 | January 2006 | |
| NCT05864365 | Enrolling by invitation | Phase 2 | Biomarker Study of ATH434 in Participants With MSA | May 23, 2023 | February 28, 2025 |
| NCT06162013 | Not yet recruiting | Phase 2 | The NADAPT Study: a Randomized Double-blind Trial of NAD Replenishment Therapy for Atypical Parkinsonism | January 2024 | December 2028 |
| NCT06174948 | Not yet recruiting | N/A | The Use of the CUE1 in People With Parkinson's Disease and Related Disorders | March 2024 | December 2025 |
| NCT03648905 | Recruiting | Clinical Laboratory Evaluation of Chronic Autonomic Failure | September 6, 2018 | December 31, 2029 | |
| NCT05238545 | Recruiting | N/A | The Effect of Gluten-free Diet on Parkinsonism | October 1, 2021 | December 31, 2025 |
| NCT05695378 | Recruiting | Phase 2 | Trial to Evaluate the Efficacy and Safety of KM-819 Treatment to Slow the Progression of Multiple System Atrophy (MSA) | February 27, 2023 | November 18, 2024 |
| NCT05698017 | Recruiting | Phase 1/Phase 2 | Study to Evaluate Investigational Allogeneic Cell Therapy Product hOMSC300 for Treatment of Early- to Moderate Stage MSA | November 7, 2022 | February 19, 2026 |
| NCT04706234 | Recruiting | Systematic Assessment of Laryngopharyngeal Function in Patients With MSA, PD, and 4repeat Tauopathies | September 1, 2017 | July 31, 2024 | |
| NCT04782284 | Recruiting | N/A | Comprehensive Swallowing Rehabilitation in Patients With MSA | May 17, 2021 | December 30, 2024 |
| NCT04782830 | Recruiting | N/A | Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms | February 5, 2021 | October 1, 2024 |
| NCT04844060 | Recruiting | Cerebro Spinal Fluid Collection (CSF) | February 2010 | December 2030 | |
| NCT06098612 | Recruiting | Early Phase 1 | PET Imaging Evaluation of [11C]SY08 | May 2024 | November 2025 |
| NCT01793168 | Recruiting | Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford | July 2010 | December 2100 | |
| NCT01799915 | Recruiting | Natural History Study of Synucleinopathies | June 2011 | December 30, 2024 | |
| NCT05121012 | Recruiting | Synaptic Loss in Multiple System Atrophy | September 1, 2021 | April 1, 2025 | |
| NCT02114242 | Recruiting | Biomarkers in Parkinsonian Syndromes | December 16, 2013 | December 16, 2025 | |
| NCT05139342 | Recruiting | N/A | Evaluation of the Efficacy of a Two-week EMST on Dysphagia in Parkinsonian Patients | November 15, 2021 | December 31, 2023 |
| NCT05167721 | Recruiting | Phase 2 | Randomized Double-Blind Placebo-Controlled Adaptive Design Trial Of Intrathecally Administered Autologous Mesenchymal Stem Cells In Multiple System Atrophy | December 15, 2021 | December 2025 |
| NCT05171205 | Recruiting | N/A | Spinal Cord Stimulation for Multiple System Atrophy | May 1, 2021 | April 30, 2025 |
| NCT05222386 | Recruiting | N/A | Community Outreach for Palliative Engagement -- Parkinson Disease | April 26, 2022 | August 31, 2026 |
| NCT03482297 | Recruiting | Phase 1/Phase 2 | Automated Abdominal Binder for Orthostatic Hypotension | March 1, 2018 | December 1, 2024 |
| NCT02429557 | Recruiting | Phase 1 | Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure | April 2015 | December 1, 2024 |
| NCT05489575 | Recruiting | N/A | CPAP for the Treatment of Supine Hypertension | June 23, 2022 | August 31, 2026 |
| NCT02897063 | Recruiting | Phase 1 | Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure | September 2016 | December 2024 |
| NCT02994719 | Recruiting | Gait Analysis in Neurological Disease | March 1, 2016 | June 20, 2025 | |
| NCT03042988 | Recruiting | N/A | Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension | January 30, 2017 | December 30, 2024 |
| NCT05526391 | Recruiting | Phase 2 | A Study of TAK-341 in Treatment of Multiple System Atrophy | November 9, 2022 | August 1, 2025 |
| NCT06203106 | Recruiting | NYSCF Scientific Discovery Biobank | November 10, 2022 | November 10, 2045 | |
| NCT03174938 | Recruiting | N/A | The Swedish BioFINDER 2 Study | May 15, 2017 | December 31, 2028 |
| NCT05634876 | Recruiting | Phase 1/Phase 2 | UB-312 in Patients With Synucleinopathies | May 31, 2023 | May 2025 |
| NCT05638477 | Recruiting | N/A | Unstructured Eye Tracking as a Diagnostic and Prognostic Biomarker in Parkinsonian Disorders | December 1, 2022 | August 15, 2024 |
| NCT03872102 | Recruiting | Facilitating Diagnostics and Prognostics of Parkinsonian Syndromes Using Neuroimaging | March 28, 2019 | August 2024 | |
| NCT03924414 | Recruiting | Phase 4 | Trial of Parkinson's And Zoledronic Acid | November 15, 2019 | October 1, 2026 |
| NCT05748028 | Recruiting | Pain and Autonomic Symptoms in Parkinson's Disease and Atypical Parkinsonisms | June 15, 2019 | December 30, 2024 | |
| NCT05807373 | Recruiting | N/A | Differential Diagnosis Between Parkinson's Disease and Multiple System Atrophy Using Digital Speech Analysis - Part 2 | March 21, 2023 | January 2, 2024 |
| NCT04165486 | Recruiting | Phase 1 | Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ION464 Administered to Adults With Multiple System Atrophy (HORIZON) | July 21, 2022 | September 2027 |
| NCT05819957 | Recruiting | N/A | Therapeutic Education for MSA Patients and Their Caregivers | June 7, 2023 | June 2026 |
| NCT05826457 | Recruiting | North American Prodromal Synucleinopathy Consortium Stage 2 | August 12, 2022 | May 1, 2025 | |
| NCT04246437 | Recruiting | Phase 1 | [18F]F-DOPA Imaging in Patients With Autonomic Failure | February 4, 2020 | February 1, 2025 |
| NCT04468919 | Recruiting | N/A | Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit | July 15, 2022 | June 30, 2025 |
| NCT04472130 | Recruiting | Neurodegenerative Diseases Registry | October 9, 2019 | August 2024 | |
| NCT04518059 | Recruiting | Misfolded Proteins in the Skin of People With Parkinson's Disease and Other Parkinsonism | March 12, 2019 | May 31, 2024 | |
| NCT05889260 | Recruiting | Speech Accessibility Project | March 15, 2023 | May 31, 2024 | |
| NCT04620382 | Recruiting | Early Phase 1 | Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients | November 9, 2020 | December 1, 2024 |
| NCT04680065 | Recruiting | Phase 1 | GDNF Gene Therapy for Multiple System Atrophy | October 3, 2023 | December 2028 |
| NCT06072105 | Recruiting | N/A | Medical Decision Making in Multiple System Atrophy | October 2023 | September 2027 |
| NCT02445469 | Terminated | N/A | Magnetic Resonance Imaging in the Diagnosis of Parkinsonian Syndromes | December 2012 | December 2016 |
| NCT03901638 | Terminated | Phase 3 | Tllsh2910 for Ataxia and Gut Microbiota Alteration in Patients of Multiple System Atrophy | April 2, 2019 | April 3, 2023 |
| NCT02149901 | Terminated | Early Phase 1 | Water and Sudafed in Autonomic Failure | October 2014 | December 2020 |
| NCT03589976 | Terminated | Phase 2 | A Futility Trial of Sirolimus in Multiple System Atrophy | September 1, 2018 | January 1, 2021 |
| NCT00997672 | Terminated | Phase 2 | Lithium in Multiple System Atrophy | October 2009 | August 2011 |
| NCT01287221 | Terminated | Phase 3 | Study of Rifampicin in Multiple System Atrophy | March 2011 | January 2013 |
| NCT01292694 | Terminated | Phase 1 | Contribution of Angiotensin II to Supine Hypertension in Autonomic Failure | March 2011 | March 2017 |
| NCT00547911 | Terminated | Phase 1/Phase 2 | Augmenting Effects of L-DOPS With Carbidopa and Entacapone | October 2007 | April 2013 |
| NCT01607268 | Terminated | Magnetic Resonance Spectroscopy in Autonomic Failure | July 2012 | January 2017 | |
| NCT00211224 | Terminated | Phase 3 | Neuroprotection and Natural History in Parkinson's Plus Syndromes (NNIPPS) | April 2000 | November 2004 |
| NCT00822913 | Unknown status | Phase 4 | Botulinum A Toxin in Patients With Parkinson's Disease | June 2008 | December 2009 |
| NCT00653783 | Unknown status | Diagnostic and Prognostic Biomarkers in Parkinson Disease | August 2007 | ||
| NCT03269201 | Unknown status | Brain Network Activation in Patients With Movement Disorders | March 1, 2019 | September 15, 2022 | |
| NCT04020198 | Unknown status | A Pilot Biomarker Study Assessing Alpha-synuclein Aggregates Across Biofluid Reservoirs in Patients With Synucleinopathies | January 15, 2020 | June 1, 2023 | |
| NCT04876326 | Unknown status | N/A | Potential Use of Autologous and Allogeneic Mesenchymal Stem Cells in Patients With Multiple System Atrophy | October 5, 2020 | October 5, 2021 |
| NCT04250493 | Unknown status | N/A | Insulin Resistance in Multiple System Atrophy | October 28, 2020 | October 28, 2023 |
| NCT03721887 | Unknown status | N/A | Exploit the Neural Source and the Feasibility of Transcranial Direct Current Stimulation for Freezing of Gait in Parkinson's Disease and Multiple System Atrophy | August 1, 2018 | July 31, 2021 |
| NCT04313530 | Unknown status | N/A | TMS Treatment in Multiple System Atrophy With Fatigue | October 1, 2019 | May 1, 2022 |
| NCT04431713 | Unknown status | Phase 2 | Exenatide Once-weekly as a Treatment for Multiple System Atrophy | September 16, 2020 | April 26, 2022 |
| NCT04965922 | Unknown status | N/A | Quality of Life of Caregivers and Patients Suffering From Multiple System Atrophy | July 1, 2021 | July 1, 2023 |
| NCT03623672 | Unknown status | North American Prodromal Synucleinopathy Consortium | August 29, 2018 | July 31, 2022 | |
| NCT00758849 | Unknown status | Phase 2 | Fipamezole in Neurogenic Orthostatic Hypotension | September 2008 | May 2009 |
| NCT03446807 | Withdrawn | Phase 2 | Safety and Efficacy of Droxidopa for Fatigue in Patients With Parkinsonism | December 2021 | July 1, 2023 |
| NCT01119417 | Withdrawn | Phase 1 | The Role of Endothelin in the Supine Hypertension of Autonomic Failure | May 2010 | May 2021 |
- Disase is a (Disease Ontology)
- DOID:0050890
- Cross Reference ID (Disease Ontology)
- GARD:7079
- Cross Reference ID (Disease Ontology)
- MESH:D012791
- Cross Reference ID (Disease Ontology)
- MESH:D019578
- Cross Reference ID (Disease Ontology)
- NCI:C84909
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:16576004
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:230297002
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0037019
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0393571
- Exact Synonym (Disease Ontology)
- Shy-Drager syndrome
- OrphaNumber from OrphaNet (Orphanet)
- 102
- MeSH unique ID (MeSH (Medical Subject Headings))
- D019578