bronchopulmonary dysplasia
Information
- Disease name
- bronchopulmonary dysplasia
- Disease ID
- DOID:11650
- Description
- "A lung disease that is characterized by underdeveloped lungs in newborns that can be easily irritated or inflamed after birth resulting in damage to the alveoli of the lungs and bronchi. Most newborns who develop BPD are born more than 10 weeks before their due dates, weigh less than 2 pounds at birth, and have breathing problems." [url:https\://www.nhlbi.nih.gov/health/bronchopulmonary-dysplasia]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT02371460 | Active, not recruiting | Phase 3 | Maternal Omega-3 Supplementation to Reduce Bronchopulmonary Dysplasia | June 23, 2015 | March 2025 |
| NCT01353313 | Active, not recruiting | Phase 3 | Hydrocortisone for BPD | August 11, 2011 | January 2025 |
| NCT05404815 | Active, not recruiting | Exposure to Plasticisers in the Neonatal Intensive Care Unit | June 2, 2020 | December 30, 2023 | |
| NCT03540680 | Active, not recruiting | N/A | p16Ink4a in Bronchopulmonary Dysplasia in Children | March 7, 2018 | December 30, 2023 |
| NCT02475434 | Active, not recruiting | N/A | Use of Human Milk Cream to Decrease Length of Stay in Extremely Premature Infants | June 10, 2015 | December 30, 2024 |
| NCT05915806 | Active, not recruiting | N/A | Enteral High-dose DHA Supplementation on Bronchopulmonary Dysplasia in Very Preterm Infants: a Collaborative Study | July 30, 2023 | March 2024 |
| NCT04255147 | Active, not recruiting | Phase 1 | Cellular Therapy for Extreme Preterm Infants at Risk of Developing Bronchopulmonary Dysplasia | October 17, 2022 | November 6, 2033 |
| NCT01632475 | Active, not recruiting | Follow-Up Study of Safety and Efficacy of Pneumostem® in Premature Infants With Bronchopulmonary Dysplasia | September 2011 | September 2026 | |
| NCT04662151 | Active, not recruiting | Phase 1 | A Clinical Safety Study of AT-100 (rhSP-D) in Preterm Neonates at High Risk for Bronchopulmonary Dysplasia (BPD) | September 1, 2021 | May 23, 2024 |
| NCT00515281 | Active, not recruiting | Phase 2/Phase 3 | Inhaled Nitric Oxide and Neuroprotection in Premature Infants | May 2008 | June 7, 2023 |
| NCT03808402 | Active, not recruiting | The Effect of Surfactant Dose on Outcomes in Preterm Infants With RDS | October 26, 2018 | March 30, 2025 | |
| NCT04560179 | Active, not recruiting | Phase 1 | Inhaled Tobramycin in BPD | March 22, 2022 | December 31, 2024 |
| NCT03231735 | Active, not recruiting | Phase 2/Phase 3 | Mid and Standard Frequency Ventilation in Infants With Respiratory Distress Syndrome | August 2, 2017 | October 31, 2024 |
| NCT03782610 | Active, not recruiting | Early Prediction of Spontaneous Patent Ductus Arteriosus (PDA) Closure and PDA-Associated Outcomes | April 1, 2019 | June 2026 | |
| NCT03717584 | Active, not recruiting | A Cohort Study of the Intestinal Microbiota of Premature Infants | December 23, 2018 | December 2026 | |
| NCT00011362 | Completed | Phase 3 | Dexamethasone Therapy in VLBW Infants at Risk of CLD | September 1992 | April 1994 |
| NCT06082414 | Completed | Systemic Management in Extremely Preterm and Extremely Low Birth Weight Infants | January 30, 2019 | January 29, 2020 | |
| NCT00167544 | Completed | Phase 2 | Randomized Trial of Hydrocortisone in Very Preterm High-Risk Infants | November 2005 | November 2012 |
| NCT00188968 | Completed | Phase 3 | Randomized Trial of Nasal Continuous Positive Airway Pressure or Synchronized Nasal Ventilation in Premature Infants. | November 2004 | February 2007 |
| NCT00208039 | Completed | N/A | Pilot Trial of Surfactant Booster Prophylaxis For Ventilated Preterm Neonates | September 2004 | November 2007 |
| NCT00233324 | Completed | Phase 3 | Surfactant Positive Airway Pressure and Pulse Oximetry Trial | February 2005 | August 2016 |
| NCT00234247 | Completed | Prolonged Outcomes After Nitric Oxide (PrONOx) | December 2002 | November 2008 | |
| NCT00314431 | Completed | Phase 3 | Post-hospitalization Nursing Effectiveness (PHONE) Study | May 1996 | August 2000 |
| NCT00319956 | Completed | Phase 2 | Trial II of Lung Protection With Azithromycin in the Preterm Infant | September 2004 | June 2012 |
| NCT00419588 | Completed | Growth of Airways and Lung Tissues in Premature and Healthy Infants | September 2006 | January 2019 | |
| NCT00422305 | Completed | Assessment of Lung Structure and Function of Infants Born Prematurely | January 2007 | January 2019 | |
| NCT00428038 | Completed | Assessment of the Pulmonary Diffusion Capacity in Healthy Infants and Infants With Chronic Lung Disease | February 2004 | December 2008 | |
| NCT00492102 | Completed | Phase 1 | Montelukast in Very Low Birthweight Infants | March 2007 | June 2011 |
| NCT00569530 | Completed | Phase 3 | Trial of Late Surfactant to Prevent BPD: A Pilot Study in Ventilated Preterm Neonates Receiving Inhaled Nitric Oxide | January 2008 | December 2012 |
| NCT00623740 | Completed | Phase 3 | PREMILOC Trial to Prevent Bronchopulmonary Dysplasia in Very Preterm Neonates | April 2008 | January 2016 |
| NCT05311228 | Completed | Phase 4 | The Efect of Azithromicyn on Bronchopulmonary Displasia in Extremely Preterm and Very Preterm Infant | June 8, 2021 | April 1, 2022 |
| NCT00757146 | Completed | Neonatal Intensive Care (NICU) Course and Hospital Outcome of Infants With BPD Treated Using Inhaled Nitric Oxide | March 2006 | February 2010 | |
| NCT00840983 | Completed | Phase 1 | Effects of Delayed Cord Clamping in Very Low Birth Weight Infants | August 2003 | December 2006 |
| NCT05235399 | Completed | Right vEntricular Function Prediction mOdel to Identify pReterm infanTs With Early BronchoPulmonary Dysplasia. | June 1, 2022 | May 5, 2023 | |
| NCT00926276 | Completed | Phase 4 | The Role of Anti-Reflux Surgery for Gastroesophageal Reflux Disease in Premature Infants With Bronchopulmonary Dysplasia | June 2009 | May 2013 |
| NCT00931632 | Completed | Phase 3 | Inhaled Nitric Oxide (INO) for the Prevention of Bronchopulmonary Dysplasia (BPD) in Preterm Infants | November 2009 | May 2014 |
| NCT00955487 | Completed | Phase 2 | Examining the Use of Non-Invasive Inhaled Nitric Oxide to Reduce Chronic Lung Disease in Premature Newborns | January 2007 | December 2014 |
| NCT01006629 | Completed | Phase 2/Phase 3 | Palivizumab for Prevention of Severe Respiratory Syncytial Virus Infection in Russian Children | November 2009 | July 2010 |
| NCT01022580 | Completed | Phase 3 | Trial of Late Surfactant for Prevention of Bronchopulmonary Dysplasia | January 2010 | January 2016 |
| NCT01035190 | Completed | Phase 3 | Efficacy and Safety of Inhaled Budesonide in Very Preterm Infants at Risk for Bronchopulmonary Dysplasia | April 2010 | July 2016 |
| NCT01039285 | Completed | Phase 4 | Exogenous Surfactant in Very Preterm Neonates in Prevention of Bronchopulmonary Dysplasia | December 2009 | June 2022 |
| NCT01124331 | Completed | N/A | Appropriate Oxygen Levels for Extremely Preterm Infants: a Prospective Meta-analysis | March 2005 | August 2014 |
| NCT01203358 | Completed | Phase 2/Phase 3 | Exosurf Neonatal and Survanta for Treatment of Respiratory Distress Syndrome | January 1991 | January 1992 |
| NCT01203488 | Completed | Phase 1/Phase 2 | Vitamin A Supplementation for Extremely-Low-Birth-Weight Infants | January 1996 | July 1999 |
| NCT05152875 | Completed | Relationship Between Fungal Colonization and Severe Bronchopulmonary Dysplasia | March 21, 2022 | May 31, 2022 | |
| NCT01223274 | Completed | Phase 1/Phase 2 | Delivery Room CPAP in Extremely Low Birth Weight Infants | July 2002 | January 2003 |
| NCT05152316 | Completed | The Baby Lung Study | September 17, 2021 | May 31, 2023 | |
| NCT01297205 | Completed | Phase 1 | Safety and Efficacy Evaluation of PNEUMOSTEM® Treatment in Premature Infants With Bronchopulmonary Dysplasia | December 2010 | December 2011 |
| NCT05082272 | Completed | The Role of Transthoracic Echocardiography in Diagnosis of Pulmonary Hypertension of Infants With Bronchopulmonary Dysplasia | January 1, 2016 | June 1, 2017 | |
| NCT05055193 | Completed | Outcome of Extremely Preterm Infants Who Received Systemic Postnatal Corticosteroid for Bronchopulmonary Dysplasia | January 1, 2013 | December 31, 2018 | |
| NCT01383850 | Completed | Phase 2 | NCPAP + Heliox as a Treatment for Infant Respiratory Distress Syndrome (RDS) | February 2008 | September 2010 |
| NCT01424553 | Completed | N/A | Respiratory Outcome at Adolescence of Very Low Birthweight Infants | October 2011 | April 2015 |
| NCT01439295 | Completed | Ascorbyl Peroxide Association With Bronchopulmonary Dysplasia | August 2010 | November 2015 | |
| NCT01440647 | Completed | N/A | Study of Nasal Ventilation In Preterm Infants To Decrease Time on The Respirator | November 2007 | January 2010 |
| NCT01460576 | Completed | Improving Prematurity-Related Respiratory Outcomes at Vanderbilt | September 2011 | December 2016 | |
| NCT01473264 | Completed | Phase 1/Phase 2 | Safety, Pk and Anti-inflammatory Effects of CC10 Protein in Premature Infants With Respiratory Distress Syndrome (RDS) | January 2000 | December 2003 |
| NCT01600430 | Completed | Phase 2/Phase 3 | Vitamin D Supplementation for Extremely Preterm Infants | June 2012 | December 2016 |
| NCT01607216 | Completed | Functional and Lymphocytic Markers of Respiratory Morbidity in Hyperoxic Preemies | August 2011 | July 2015 | |
| NCT01644981 | Completed | Prospective Study on Plasma Pro-endothelin-1 in Predicting Bronchopulmonary Dysplasia | May 2012 | December 2013 | |
| NCT01648855 | Completed | Consequences of Antiangiogenic Factors Involved in Preeclampsia on Intra-uterine Growth Restricted Preterm Newborn | June 2012 | June 2016 | |
| NCT05036603 | Completed | N/A | Comparison of the Acute Effects of Chest Physiotherapy Methods Applied in Different Positions in Preterm Newborns | April 1, 2022 | August 15, 2022 |
| NCT01717625 | Completed | Phase 2 | The Efficacy and Safety of Montelukast Sodium in the Prevention of Bronchopulmonary Dysplasia | November 2011 | October 2013 |
| NCT04941963 | Completed | Ultrasound Assessment of Diaphragmatic Function in Infants With BPD | November 26, 2019 | July 15, 2022 | |
| NCT01722760 | Completed | Tidal Neonatal NO, Vitamins A and D, and Infant Lung Disease - The AD-ON Study | August 2013 | November 2015 | |
| NCT01739114 | Completed | N/A | Assessment of Lung Aeration at Birth | May 2013 | October 2014 |
| NCT04936477 | Completed | N/A | Ventilation-perfusion (V/Q) Ratio and Alveolar Surface Area in Preterm Infants | September 29, 2020 | January 30, 2023 |
| NCT01748565 | Completed | Gastrin-Releasing Peptide and Bronchopulmonary Dysplasia | May 2012 | August 2016 | |
| NCT01780155 | Completed | Genes Associated With Bronchopulmonary Dysplasia and Retinopathy of Prematurity | June 24, 2013 | August 1, 2020 | |
| NCT01828957 | Completed | Phase 2 | Efficacy and Safety Evaluation of Pneumostem® Versus a Control Group for Treatment of BPD in Premature Infants | April 2013 | August 2015 |
| NCT04792099 | Completed | N/A | CPAP Or Nasal Cannula Oxygen for Preterm Infants: A Randomized Controlled Trial | August 16, 2021 | March 29, 2023 |
| NCT01897987 | Completed | N/A | Follow-up Safety and Efficacy Evaluation on Subjects Who Completed PNEUMOSTEM® Phase-II Clinical Trial | January 2014 | March 2020 |
| NCT01941745 | Completed | Phase 2 | Efficacy of Recombinant Human Clara Cell 10 Protein (rhCC10) Administered to Premature Neonates With Respiratory Distress Syndrome | October 2013 | August 25, 2017 |
| NCT01962818 | Completed | N/A | High Frequency Oscillatory Ventilation Combined With Intermittent Sigh Breaths: Effects on Lung Volume Monitored by Electric Tomography Impedance. | January 2014 | January 1, 2023 |
| NCT01996670 | Completed | Early NCPAP Before Surfactant Treatment in Very Preterm Infants With RDS | January 2007 | ||
| NCT02023788 | Completed | Long-term Safety and Efficacy Follow-up Study of PNEUMOSTEM® in Patients Who Completed PNEUMOSTEM® Phase-I Study | April 2014 | October 2016 | |
| NCT04348799 | Completed | Thrombocytopoiesis and Platelet Homeostasis in Infants With Bronchoplumonary Dysplasia | January 1, 2019 | January 1, 2020 | |
| NCT02083562 | Completed | Biomarkers and Volumetric Capnography in BPD | November 2013 | June 2018 | |
| NCT02102711 | Completed | N/A | Oral Vitamin A Supplementation in Neonates With Birth Weight < 1500 g | April 2014 | April 2016 |
| NCT02142621 | Completed | N/A | Transpyloric Feeding in Severe Bronchopulmonary Dysplasia | December 18, 2014 | July 15, 2016 |
| NCT02210026 | Completed | Phase 1 | Seattle-PAP Bubble Nasal CPAP and Work of Breathing | August 2014 | October 2015 |
| NCT02249143 | Completed | N/A | Duration of Continuous Positive Airway Pressure and Pulmonary Function Testing in Preterm Infants | September 2014 | September 2017 |
| NCT04234152 | Completed | N/A | Complete Shielding of Multivitamins to Reduce Toxic Peroxides in the Parenteral Nutrition: A Pilot Study | November 23, 2020 | January 17, 2022 |
| NCT02287116 | Completed | N/A | Continuous Positive Airway Pressure Via Binasal Prong vs Nasal Mask: a Randomised Controlled Trial | May 2014 | October 2014 |
| NCT02381366 | Completed | Phase 1/Phase 2 | Safety and Efficacy of PNEUMOSTEM® in Premature Infants at High Risk for Bronchopulmonary Dysplasia (BPD) - a US Study | March 2015 | May 2018 |
| NCT02443961 | Completed | Phase 1 | Mesenchymal Stem Cell Therapy for Bronchopulmonary Dysplasia in Preterm Babies | April 2, 2019 | July 7, 2022 |
| NCT02447250 | Completed | Phase 4 | Preterm Infant Inhaled Albuterol Dosing | October 24, 2013 | December 30, 2014 |
| NCT04191239 | Completed | Comparing Two Different Modes of Ventilation in Pretem Neonates Bilevel VG and PRVC | January 1, 2021 | June 30, 2021 | |
| NCT04163822 | Completed | Analysis of BPD in Premature Infants With Typical Imaging Changes | January 1, 2020 | May 20, 2021 | |
| NCT02527798 | Completed | Phase 2 | Safety of Furosemide in Premature Infants at Risk of Bronchopulmonary Dysplasia (BPD) | November 27, 2015 | October 15, 2019 |
| NCT02723513 | Completed | N/A | Bronchopulmonary Dysplasia: From Neonatal Chronic Lung Disease to Early Onset Adult COPD | April 1, 2016 | September 2020 |
| NCT02729844 | Completed | Neolifes Heart - Pulmonary Hypertension in Preterm Children | June 1, 2016 | August 25, 2021 | |
| NCT02784821 | Completed | Phase 2 | Antibiotic "Dysbiosis" in Preterm Infants | January 16, 2017 | September 11, 2019 |
| NCT02788110 | Completed | N/A | Work of Breathing During Non-invasive Ventilation in Premature Neonates | August 2016 | June 2018 |
| NCT02819050 | Completed | N/A | Effective Approaches & Strategies to Ease Off Nasal CPAP In Preterm Infants | January 2014 | January 2016 |
| NCT02820818 | Completed | Pulmonary Outcomes of Bronchopulmonary Dysplasia in Young Adulthood | June 2016 | December 2021 | |
| NCT02921308 | Completed | Pulmonary MRI of Ex-preterm Children With and Without BPD To Understand Risk of Emphysematous Changes | January 5, 2018 | September 18, 2019 | |
| NCT02967549 | Completed | N/A | Neurally Adjusted Ventilatory Assist vs Proportional Assist Ventilation | November 2016 | August 2018 |
| NCT04077333 | Completed | N/A | MISA to NRDS：a Multicenter Study in China | July 1, 2017 | March 30, 2019 |
| NCT02999373 | Completed | Phase 2 | Autologous Cord Blood Mononuclear Cells for Bronchopulmonary Dysplasia in Very Preterm Neonates | July 1, 2018 | January 1, 2020 |
| NCT03014453 | Completed | GER Poses a Potential Risk for Late Complications of BPD | January 9, 2017 | July 22, 2018 | |
| NCT04062136 | Completed | Phase 1 | Umbilical Cord Mesenchymal Stem Cells Transplantation in the Treatment of Bronchopulmonary Dysplasia | March 1, 2019 | November 30, 2020 |
| NCT03041740 | Completed | Phase 1 | Fluid Filled Lung Oxygenation Assistance Trial | June 27, 2017 | June 10, 2019 |
| NCT03062709 | Completed | N/A | A Study of Tobacco Smoke and Children With Respiratory Illnesses | March 12, 2017 | April 30, 2017 |
| NCT03229967 | Completed | Gastrointestinal Microbiome Influence on the Development of Bronchopulmonary Dysplasia | July 5, 2017 | December 30, 2020 | |
| NCT03275415 | Completed | Phase 4 | Intratracheal Budesonide/Surfactant Prevents BPD | July 1, 2019 | June 30, 2022 |
| NCT03485703 | Completed | Phase 4 | Azithromycin in the Prevention of Lung Injury in Premature Newborn | August 28, 2012 | April 13, 2016 |
| NCT00000567 | Completed | Phase 3 | High Frequency Ventilation in Premature Infants (HIFI) | August 1984 | |
| NCT00000576 | Completed | Phase 3 | Inhaled Beclomethasone to Prevent Chronic Lung Disease | June 1993 | April 1999 |
| NCT00004669 | Completed | Phase 2 | Phase II Pilot Study of Early Cortisol Replacement to Prevent Bronchopulmonary Dysplasia | June 1996 | |
| NCT00004785 | Completed | Phase 3 | Phase III Randomized, Double-Blind Study of Dexamethasone Vs Dexamethasone/Methylprednisolone Vs Placebo for Bronchopulmonary Dysplasia | November 1995 | |
| NCT00004805 | Completed | N/A | Study of the Effect of Four Methods of Cardiopulmonary Resuscitation Instruction on Psychosocial Response of Parents With Infants at Risk of Sudden Death | September 1991 | August 1997 |
| NCT00005287 | Completed | Late Sequelae of Bronchopulmonary Dysplasia | July 1986 | June 1989 | |
| NCT00005289 | Completed | Risk Factors in Bronchopulmonary Dysplasia (Newborn Lung Project) | July 1987 | July 2008 | |
| NCT00005293 | Completed | Antecedents of Bronchopulmonary Dysplasia | December 1988 | November 1990 | |
| NCT00005294 | Completed | Developmental Sequelae of Severe Chronic Lung Disorders | July 1989 | June 1995 | |
| NCT00005376 | Completed | Premature Birth and Its Sequelae in Women | September 1993 | August 1998 | |
| NCT00005683 | Completed | Clinical Interventions in Respiratory Distress Syndrome and Neonatal Lung Injury - SCOR in Lung Biology and Diseases in Infants and Children | December 1986 | November 1997 | |
| NCT00000548 | Completed | Phase 3 | Inhaled NO in Prevention of Chronic Lung Disease | March 2000 | February 2006 |
| NCT00006058 | Completed | Study of the Pathobiology of Bronchopulmonary Dysplasia in Newborns | September 1996 | ||
| NCT00006401 | Completed | Phase 3 | Inhaled Nitric Oxide for Preventing Chronic Lung Disease in Premature Infants | September 2000 | October 2007 |
| NCT03546543 | Completed | N/A | The Effects of Position on the Oxygenation Instability of Premature Infants as Documented by SpO2 Histograms | January 1, 2018 | March 30, 2020 |
| NCT03503994 | Completed | N/A | Inhaled Corticosteroids for Treatment of Bronchopulmonary Dysplasia | July 27, 2001 | November 15, 2006 |
| NCT03682575 | Completed | Work of Breathing in Premature Infants at Discharge | November 10, 2020 | February 28, 2023 | |
| NCT03373539 | Completed | Neurotrophin Expression in Infants as a Predictor of Respiratory and Neurodevelopmental Outcomes | December 2014 | August 2019 | |
| NCT03649932 | Completed | Phase 1 | Enteral L Citrulline Supplementation in Preterm Infants - Safety, Efficacy and Dosing | September 25, 2018 | June 21, 2021 |
| NCT03385330 | Completed | N/A | BPD Saturation TARgeting | June 1, 2018 | September 1, 2023 |
| NCT03411018 | Completed | Respiratory Management of Preterm Infants and Bronchopulmonary Dysplasia | January 1, 2012 | December 31, 2017 | |
| NCT05621785 | Enrolling by invitation | Corticosteroid Use in Premature Babies and Lung Ultrasonografi Use in the Progression to Bronchopulmonary Dysplasia | March 1, 2022 | March 30, 2024 | |
| NCT05925075 | Enrolling by invitation | Point of Care Lung Ultrasound in Preterm Infants With Respiratory Distress | April 17, 2023 | April 1, 2025 | |
| NCT06443528 | Not yet recruiting | Comparison of Lung Ultrasound Scores With Clinical Models for Predicting Bronchopulmonary Dysplasia：A Multi-center Prospective Cohort Study | June 1, 2024 | June 30, 2029 | |
| NCT04035629 | Not yet recruiting | Phase 1 | 129Xe MRI in Pediatric Population With BPD | August 1, 2023 | December 31, 2024 |
| NCT04696003 | Not yet recruiting | Phase 3 | Treatment of Classic Mid-trimester PPROM by Means of Continuous Amnioinfusion | January 1, 2021 | May 30, 2025 |
| NCT04862377 | Not yet recruiting | Phase 3 | Intratracheal Budesonide With Surfactant to Prevent Bronchopulmmonary Dysplasia. | October 1, 2021 | April 1, 2026 |
| NCT05136235 | Not yet recruiting | N/A | Pulmonary Hypertension in Extremely Preterm Infants | January 2022 | December 2025 |
| NCT05629910 | Not yet recruiting | N/A | NeO2Matic-Pilot Trial | January 1, 2024 | July 1, 2025 |
| NCT05638568 | Not yet recruiting | N/A | Fast Assessment of Surfactant Deficiency in Preterm Infants to Speed up Treatment | July 1, 2024 | January 1, 2029 |
| NCT05898633 | Not yet recruiting | Phase 1 | Recombinant Surfactant Protein D (rfhSP-D) to Prevent Neonatal Chronic Lung Disease | December 2023 | December 2024 |
| NCT06342752 | Not yet recruiting | The Role of VOCs, Airway Mucins and Airway Microbiome in Bronchopulmonary Dysplasia | April 2024 | September 2027 | |
| NCT06373289 | Not yet recruiting | N/A | Target Oxygen Ranges in Infants With Pulmonary Hypertension | July 1, 2025 | July 1, 2030 |
| NCT05547139 | Recruiting | N/A | Impact of Extended CPAP on Bronchopulmonary Dysplasia | October 10, 2022 | December 31, 2024 |
| NCT03512158 | Recruiting | N/A | Non-invasive Respiratory Support in Preterm Infants | May 15, 2018 | December 31, 2023 |
| NCT04078906 | Recruiting | N/A | SMOFlipid and Incidence of BPD in Preterm Infants | December 16, 2019 | October 2024 |
| NCT04107701 | Recruiting | Indoor Air Quality and Respiratory Morbidity in School-Aged Children With BPD | July 22, 2019 | July 31, 2025 | |
| NCT06279741 | Recruiting | Phase 1/Phase 2 | Safety and Efficacy of MSC-EVs in the Prevention of BPD in Extremely Preterm Infants | December 28, 2023 | December 31, 2029 |
| NCT03576885 | Recruiting | Phase 1/Phase 2 | Inhaled Nitric Oxide for Pulmonary Hypertension and Bronchopulmonary Dysplasia | July 15, 2019 | December 1, 2024 |
| NCT04239690 | Recruiting | N/A | Preservation of Blood in Extremely Preterm Infants | March 15, 2020 | June 30, 2024 |
| NCT04270045 | Recruiting | Forced Oscillometry in Infants With Bronchopulmonary Dysplasia | February 6, 2020 | December 2024 | |
| NCT04278404 | Recruiting | Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) | March 5, 2020 | July 2024 | |
| NCT03455686 | Recruiting | N/A | Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease | April 19, 2018 | December 2024 |
| NCT03657693 | Recruiting | MRI in BPD Subjects | May 4, 2018 | August 2025 | |
| NCT03372525 | Recruiting | N/A | Invasive Ventilation Strategies for Neonates With Acute Respiratory Distress Syndrome Syndrome (ARDS) | December 1, 2018 | December 31, 2024 |
| NCT04003857 | Recruiting | Phase 2 | Follow-up Study of Safety and Efficacy in Subjects Who Completed PNEUMOSTEM® Phase II (MP-CR-012) Clinical Trial | July 5, 2019 | June 30, 2027 |
| NCT03346343 | Recruiting | N/A | Pulmonary Function Using Non-invasive Forced Oscillometry | December 6, 2017 | May 2027 |
| NCT06110481 | Recruiting | Reversibility of Bronchial Obstruction in Children Born Preterm | April 1, 2021 | December 1, 2025 | |
| NCT04785859 | Recruiting | Multiparametric Bronchopulmonary Prediction | December 1, 2020 | March 2024 | |
| NCT04821453 | Recruiting | N/A | NAVA vs. CMV Crossover in Severe BPD | September 13, 2021 | October 2025 |
| NCT04825197 | Recruiting | Phase 2 | Late Surfactant After a Recruitment Maneuver in Extremely Low Gestational Age Newborns - LATE-REC-SURF Trial | December 1, 2021 | February 1, 2025 |
| NCT06270199 | Recruiting | Phase 2 | Use of Mesenchymal Stem Cells in Pre-term Patients With Bronchopulmonary Dysplasia. | January 11, 2024 | December 2026 |
| NCT04905732 | Recruiting | N/A | Nasal High-frequency Oscillatory Ventilation (NHFOV) for Ventilated Newborn Infants With BPD | May 20, 2021 | December 31, 2024 |
| NCT03631420 | Recruiting | Phase 1 | Mesenchymal Stem Cells for Prevention of Bronchopulmonary Dysplasia in Infants | October 26, 2018 | July 31, 2027 |
| NCT04984057 | Recruiting | N/A | Optimal Dose of Surfactant for Preterm Infants With Respiratory Distress Syndrome | August 1, 2021 | December 31, 2024 |
| NCT03253263 | Recruiting | Phase 2 | A Clinical Efficacy and Safety Study of OHB-607 in Preventing Bronchopulmonary Dysplasia in Extremely Premature Infants | May 9, 2019 | January 21, 2028 |
| NCT03797183 | Recruiting | Genesis Electrical Impedance Tomography (EIT): A Preliminary Study | May 3, 2019 | November 30, 2024 | |
| NCT03142568 | Recruiting | Phase 2 | Safety of Sildenafil in Premature Infants | April 2, 2018 | March 2025 |
| NCT05285345 | Recruiting | Implementation of a Consensus-Based Discharge Protocol for Preterm Infants With Lung Disease | September 27, 2023 | November 2025 | |
| NCT06000761 | Recruiting | N/A | Frequent Standardized Oral Care Using Human Milk in the Neonatal Intensive Care Unit | November 23, 2023 | December 20, 2026 |
| NCT05446272 | Recruiting | N/A | The Diaphragmatic Initiated Ventilatory Assist (DIVA) Trial | August 3, 2022 | March 31, 2027 |
| NCT05446389 | Recruiting | N/A | PAL to Improve Oral Feeding for Infants With Chronic Lung Disease | June 8, 2022 | December 31, 2024 |
| NCT05568264 | Recruiting | N/A | Effects of a Physical Therapy Intervention on Motor Delay in Infants Admitted to a Neonatal Intensive Care Unit | October 1, 2022 | December 31, 2026 |
| NCT05618769 | Recruiting | N/A | Towards Life-Long Healthy Lungs: A Multidisciplinary Follow-up Framework for Preterm Infants | July 18, 2022 | July 31, 2025 |
| NCT06427642 | Recruiting | N/A | Efficacy Evaluation of UCB-MNCs in the Treatment of Refractory Neonatal Diseases | April 1, 2022 | April 30, 2025 |
| NCT05682807 | Recruiting | Phase 3 | Effect of Caffeine Versus Probiotic on Preterm Neonates With Bronchopulmonary Dysplasia | June 30, 2022 | June 2025 |
| NCT05711966 | Recruiting | N/A | Comparison of INRECSURE and LISA in Preterm Neonates With RDS | January 9, 2023 | April 15, 2026 |
| NCT05777512 | Recruiting | N/A | Randomized Controlled Crossover Trial of Postpyloric Feedings to Improve Pulmonary Outcomes in High-risk Preterm Infants | October 2024 | February 2026 |
| NCT05849077 | Recruiting | N/A | Optimization of Saturation Targets And Resuscitation Trial (OptiSTART) | February 26, 2024 | April 1, 2029 |
| NCT05898022 | Recruiting | Phase 4 | Pragmatic Research on Diuretic Management in Early BPD Pilot | August 17, 2023 | September 30, 2025 |
| NCT06421519 | Recruiting | Phase 1/Phase 2 | Different Levels of BiPAP | May 23, 2024 | August 1, 2024 |
| NCT05944055 | Recruiting | 25OH Vitamin D Overdoses and Risk of Bronchopulmonary Dysplasia or Death | January 1, 2023 | December 1, 2023 | |
| NCT05986032 | Recruiting | Respiratory Oscillometry for the Prediction of Bronchopulmonary Dysplasia | July 15, 2023 | September 24, 2024 | |
| NCT04890158 | Suspended | N/A | Prone Versus Supine Positioning and the Impact on Bronchopulmonary Dysplasia in Very Low Birth Weight Infants. | December 7, 2021 | June 2024 |
| NCT04619602 | Suspended | Phase 1 | Inhaled Treatment for Bronchopulmonary Dysplasia | August 1, 2024 | September 1, 2025 |
| NCT05030012 | Terminated | N/A | Maintaining Optimal HVNI Delivery Using Automatic Titration of Oxygen in Preterm Infants | September 2, 2021 | October 19, 2023 |
| NCT03475264 | Terminated | MRI of Lung Structure and Function in Preterm Children | September 1, 2018 | March 20, 2024 | |
| NCT00308789 | Terminated | Phase 2 | A Trial of Infant Flow Biphasic Nasal Continuous Airway Pressure (NCPAP) Versus Infant Flow NCPAP for the Facilitation of Extubation in Infants </= 1250 Grams | April 2006 | December 2009 |
| NCT00215540 | Terminated | Phase 2 | SURFAXIN® Treatment for Prevention of Bronchopulmonary Dysplasia (BPD) in Very Low Birth Weight (VLBW) Infants. | February 2005 | July 2006 |
| NCT01748045 | Terminated | Phase 2/Phase 3 | Study of Inhaled Nitric Oxide (iNO) and Respiratory Outcomes in Late Preterm Infants | March 2013 | July 2014 |
| NCT03542812 | Terminated | Early Phase 1 | L-citrulline and Pulmonary Hypertension Associated With Bronchopulmonary Dysplasia | July 30, 2019 | August 31, 2022 |
| NCT03532555 | Terminated | N/A | Enteral Zinc to Improve Growth in Infants at Risk for Bronchopulmonary Dysplasia | March 22, 2018 | August 25, 2022 |
| NCT04506619 | Terminated | Safety and Efficacy Outcomes Following Previously Administered Short-Term Treatment With SHP607 in Extremely Premature Infants | September 9, 2020 | August 5, 2022 | |
| NCT00303082 | Terminated | Phase 3 | Probiotics for the Prevention of Premature Birth and Neonatal Related Morbidity | January 2006 | August 2009 |
| NCT03701074 | Terminated | Phase 2 | Randomized Controlled Trial to Evaluate the Safety and Efficacy of Acetaminophen in Preterm Infants Used in Combination With Ibuprofen for Closure of the Ductus Arteriosus | December 15, 2018 | December 2, 2020 |
| NCT00005777 | Terminated | Phase 3 | Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE) | February 1998 | September 2002 |
| NCT03857841 | Terminated | Phase 1 | A Safety Study of IV Stem Cell-derived Extracellular Vesicles (UNEX-42) in Preterm Neonates at High Risk for BPD | October 9, 2019 | May 20, 2021 |
| NCT02524249 | Terminated | N/A | Early Versus Late Caffeine for ELBW Newborns | September 2015 | June 2019 |
| NCT00156572 | Terminated | Phase 3 | Management of Hyponatremia in Preterm Infants on Diuretics | April 2005 | December 2007 |
| NCT04274192 | Terminated | N/A | Effect of Synchronized vs. Continuous HFNC Using NAVA on WOB in Infants With BPD | December 9, 2020 | January 28, 2021 |
| NCT01329432 | Unknown status | Phase 4 | Surfactant Administration During Spontaneous Breathing | December 2010 | December 2011 |
| NCT03774537 | Unknown status | Phase 1/Phase 2 | Human Mesenchymal Stem Cells For Infants At High Risk For Bronchopulmonary Dysplasia | March 1, 2019 | December 31, 2021 |
| NCT03850457 | Unknown status | Epidemiological Study for Bronchopulmonary Dysplasia (BPD) in China | January 1, 2020 | December 2022 | |
| NCT03873506 | Unknown status | Phase 1 | Follow-Up Study of Mesenchymal Stem Cells for Bronchopulmonary Dysplasia | July 1, 2018 | December 31, 2020 |
| NCT03876704 | Unknown status | Phase 3 | Effects of Fat-soluble Vitamins Supplementation on Common Complications and Neural Development in Very Low Birth Weight Infants | January 29, 2019 | December 31, 2020 |
| NCT03961139 | Unknown status | N/A | Continuous Versus Intermittent Bolus Feeding in Very Preterm Infants - Effect on Respiratory Morbidity | December 3, 2019 | December 2022 |
| NCT04019106 | Unknown status | Phase 1/Phase 2 | Budesonide With Intratracheal Surfactants in Extremely Preterm Infants | October 15, 2019 | January 15, 2021 |
| NCT04050488 | Unknown status | Phase 4 | Zinc Supplementation on Very Low Birth Weight Infant | August 20, 2019 | July 31, 2020 |
| NCT03035214 | Unknown status | Phase 2 | Study to Justify Steroid Use in Preterm Neonates to Prevent Bronchopulmonary Dysplasia | February 19, 2017 | December 31, 2017 |
| NCT04184648 | Unknown status | Comparison of Classification Standards of BPD in Premature Infants | June 1, 2020 | June 29, 2022 | |
| NCT02523521 | Unknown status | N/A | Impact of an Exercise Program for Children Aged 4 to 6 Years With Bronchopulmonary Dysplasia | August 2015 | November 2015 |
| NCT04209088 | Unknown status | N/A | Interest of Pulmonary Ultrasound to Predict Evolution Towards Bronchopulmonary Dysplasia in Premature Infants at Gestational Age Less Than or Equal to 34 Weeks of Gestation | May 29, 2020 | June 6, 2023 |
| NCT04237844 | Unknown status | Clinic Features and Outcome of BPD (SGBPD) | December 1, 2020 | December 30, 2021 | |
| NCT02140580 | Unknown status | Phase 4 | OPTIMIST-A Trial: Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on CPAP | December 2011 | June 2022 |
| NCT02050971 | Unknown status | Phase 1 | Autologous Cord Blood Infusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonates | October 2010 | December 2015 |
| NCT04393337 | Unknown status | N/A | Estimating Length of Endotracheal Tube Insertion Using Gestational Age or Nasal-Tragus Length in Newborn Infants | June 15, 2020 | December 2023 |
| NCT04497740 | Unknown status | Follow-up Results of Newborns With Tracheostomy | August 10, 2020 | December 31, 2020 | |
| NCT04499196 | Unknown status | Glucocorticoids and Pulmonary Hypertension | July 29, 2020 | July 29, 2022 | |
| NCT04555889 | Unknown status | N/A | The Impact of Lung Recruitment Maneuver in 24-32 Weekers, and the Incidence of Bronchopulmonary Dysplasia | October 31, 2020 | December 30, 2022 |
| NCT01989442 | Unknown status | N/A | Nasal Mask and Prong Use in Non-invasive Ventilation for Newborns | November 2013 | January 2015 |
| NCT01959009 | Unknown status | N/A | High Frequency Oscillatory Ventilation Combined With Intermittent Sigh Breaths: Effects on Blood Oxygenation and Stability of Oxygenation | August 2014 | June 2022 |
| NCT01721655 | Unknown status | Phase 2/Phase 3 | Determining the Effect of Spironolactone on Electrolyte Supplementation in Preterm Infants With Chronic Lung Disease | October 2012 | December 2016 |
| NCT01652118 | Unknown status | Phase 3 | Clarithromycin Prophylaxis in Preterm Infants Colonisation With Ureaplasma Urealyticum and Mycoplasma Hominis | October 2011 | January 2013 |
| NCT01373008 | Unknown status | Phase 2 | Inhaled Extra-fine Hydrofluoalkane-beclomethasone (QVAR) in Premature Infants With Bronchopulmonary Dysplasia (BPD) | June 2011 | June 2016 |
| NCT03601416 | Unknown status | Phase 2 | Human Mesenchymal Stem Cells For Moderate and Severe Bronchopulmonary Dysplasia | July 1, 2019 | December 31, 2021 |
| NCT01268215 | Unknown status | Phase 2 | Pilot Study of Topical Steroid for Prevention of Chronic Lung Disease in Extremely Premature Infants. | July 2010 | December 2013 |
| NCT01207869 | Unknown status | Phase 1 | Intratracheal Umbilical Cord-derived Mesenchymal Stem Cells for Severe Bronchopulmonary Dysplasia | July 2010 | July 2012 |
| NCT05181319 | Unknown status | Prediction for Bronchopulmonary Dysplasia | January 1, 2018 | December 1, 2022 | |
| NCT00904774 | Unknown status | Genetic Susceptibility for Bronchopulmonary Dysplasia in Preterm Infants | May 2009 | ||
| NCT00254176 | Unknown status | Phase 2/Phase 3 | Cysteine Supplementation in Critically Ill Neonates | September 2006 | July 2011 |
| NCT03521063 | Unknown status | Phase 4 | Efficacy of Adding Budesonide to Poractant Alfa to Prevent Bronchopulmonary Dysplasia. | January 1, 2018 | December 31, 2019 |
| NCT03538977 | Unknown status | N/A | Hydrotherapy in Premature Infants With Bronchopulmonary Dysplasia | October 11, 2018 | December 2019 |
| NCT03558334 | Unknown status | Phase 1 | Human Mesenchymal Stem Cells For Bronchopulmonary Dysplasia | June 28, 2018 | June 30, 2022 |
| NCT01895075 | Withdrawn | Phase 2 | Inhaled Budesonide for Non-ventilated Infants at High Risk of Bronchopulmonary Dysplasia: the i-BUD Pilot Study | January 1, 2019 | September 1, 2020 |
| NCT03645525 | Withdrawn | Phase 1/Phase 2 | Intratracheal Umbilical Cord-derived Mesenchymal Stem Cell for the Treatment of Bronchopulmonary Dysplasia (BPD) | December 1, 2019 | April 1, 2023 |
| NCT02282176 | Withdrawn | Phase 3 | TINN2: Treat Infection in NeoNates 2 | January 2015 | January 2018 |
| NCT02996162 | Withdrawn | Hypercapnia and Its Association With Long-term Respiratory Morbidities in Premature Infants With Chronic Lung Disease | December 1, 2020 | May 6, 2021 | |
| NCT00742534 | Withdrawn | Phase 1 | Phase 1 Intravenous Citrulline for the Prevention of Bronchopulmonary Dysplasia in Preterm Infants | August 2008 | August 2009 |
| NCT05053269 | Withdrawn | Body Weight Growth After Birth and Bronchopulmonary Dysplasia | October 1, 2021 | December 31, 2024 | |
| NCT03378063 | Withdrawn | Early Phase 1 | Stem Cells for Bronchopulmonary Dysplasia | November 1, 2017 | December 30, 2022 |
- Disase is a (Disease Ontology)
- DOID:850
- Cross Reference ID (Disease Ontology)
- ICD10CM:P27.1
- Cross Reference ID (Disease Ontology)
- MESH:D001997
- Cross Reference ID (Disease Ontology)
- NCI:C90599
- Exact Synonym (Disease Ontology)
- Bronchopulmonary dysplasia of newborn
- Exact Synonym (Disease Ontology)
- Chronic lung disease of prematurity
- Exact Synonym (Disease Ontology)
- Neonatal chronic lung disease
- Exact Synonym (Disease Ontology)
- neonatal chronic respiratory disease
- Exact Synonym (Disease Ontology)
- Perinatal bronchopulmonary dysplasia
- Exact Synonym (Disease Ontology)
- Respiratory insufficiency
- OrphaNumber from OrphaNet (Orphanet)
- 70589
- MeSH unique ID (MeSH (Medical Subject Headings))
- D001997