periodontitis

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Information
Disease name
periodontitis
Disease ID
DOID:824
Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT05722613 Active, not recruiting Diagnostic Potential of the Salivary Biomarkers to Differentiate Statuses of Periodontitis May 1, 2022 June 1, 2023
NCT05557617 Active, not recruiting Periodontitis and Periodontal Bacteria in Dementia October 30, 2020 December 31, 2024
NCT06075680 Active, not recruiting N/A Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases March 4, 2022 November 2023
NCT05259982 Active, not recruiting N/A Vital Root-resective Therapy in Furcation-involved Maxillary Molars March 4, 2022 December 31, 2024
NCT06049589 Active, not recruiting N/A Therapeutic Application of Coconut Oil in Oral Health November 1, 2022 August 2024
NCT06177119 Active, not recruiting N/A Amoxicillin and Metronidazole During or After the Periodontal Treatment January 31, 2012 December 31, 2024
NCT05834946 Active, not recruiting N/A Biological Responses Affecting Early-stage Dental Implant Placement in Patients With History of Periodontitis March 4, 2021 May 30, 2025
NCT06341439 Active, not recruiting N/A Clinical Efficacy of Mouthrinses Based on Chlorhexidine 0.12% and CITROX® February 18, 2023 March 30, 2024
NCT06129357 Active, not recruiting Evaluation of Nutritional Habits, Oral Hygiene, Relationship Between Dental Caries and Periodontal Condition February 2, 2023 November 20, 2023
NCT05809817 Active, not recruiting Oral Health Policy for Patients With Type 2 Diabetes Mellitus in Chile: A Microsimulation Model Based on Real-world Data March 1, 2023 December 2024
NCT05237739 Active, not recruiting N/A Treatment of Advanced Grade III Periodontal Furcation Lesions February 5, 2022 March 2024
NCT05215431 Active, not recruiting Antioxidant Profile in Patients With Systemic Sclerosis and Periodontitis February 5, 2019 March 1, 2024
NCT06191497 Active, not recruiting N/A The Effect of Smoking and Chlorhexidine on Periodontal Tissues After Non- Surgical Periodontal Therapy in Patients With Periodontitis March 14, 2022 May 1, 2024
NCT04983225 Active, not recruiting Phase 1 The Safety and Tolerability of Initial Periodontal Therapy Combined With Human Dental Pulp Stem Cell Injection in the Treatment of Chronic Periodontitis July 31, 2021 August 31, 2024
NCT04392804 Active, not recruiting Efficacy of Intraseptal Anesthesia of 4% Articaine With Epinephrine Achieved by Computer-controlled Delivery System May 19, 2020 December 30, 2023
NCT03631693 Active, not recruiting N/A Imaging Analysis Following Periodontal Surgery February 21, 2018 June 30, 2024
NCT05799261 Active, not recruiting N/A Novel Protocol for Supportive Periodontal Therapy January 1, 2022 February 5, 2026
NCT00569075 Completed Apoptic Biomarkers of Periodontal Disease October 2006 October 2009
NCT00662532 Completed Phase 3 Antibiotic Study for Dental Implants April 2008 April 2009
NCT00668746 Completed Phase 4 Long-term Safety of Minocycline in Patients With Gum Disease December 2007 February 2009
NCT00681564 Completed Phase 3 Periodontal Infection and Endothelial Dysfunction May 2008 January 2012
NCT00689143 Completed Phase 1 A Safety/Tolerability and Pharmakokinetic Study of Sargramostim Administrated in the Gingiva August 2008 October 2008
NCT00707369 Completed Phase 4 Adjunctive Antimicrobial Therapy of Periodontitis: Long-Term Effects on Disease Progression and Oral Microbiological Colonization October 2008 January 2012
NCT00734708 Completed Phase 3 Phase 3 Clinical Trial of Periodontal Tissue Regeneration Using Fibroblast Growth Factor-2(Trafermin) August 2008
NCT00762762 Completed Phase 3 Effectiveness of a Triclosan Containing Toothpaste in Maintaining Periodontal Health in a Type 2 Diabetic Population March 2006 December 2008
NCT00801164 Completed Phase 1 Exploratory Study of Iocide Oral Rinse in a Diabetic Population December 2008 June 2010
NCT00952536 Completed Phase 2 Effect of Dietary Intake of Dried Whole Food Concentrates (Juice Plus) on Clinical Outcomes Following Periodontal Therapy: A Pilot Study February 2005 December 2010
NCT00990041 Completed Release of Cytokines by Stimulated Peripheral Blood Mononuclear Cells (PBMC) From Chronic Periodontitis Subjects
NCT01015404 Completed Phase 3 A Study to Assess the Safety of Using Fibroblast Growth Factor-2 With Periodontal Surgery in Japan (Phase 3) November 2009
NCT01040286 Completed Phase 2 The Efficacy and Safety of Flurbiprofen Chip Versus Chlorhexidine Chip (Periochip®) in Therapy of Adult Chronic Periodontitis August 2009 June 2010
NCT01045070 Completed Periodontitis and Coronary Heart Disease October 2009 May 2012
NCT01094639 Completed N/A Periodontal Infection and Systemic Inflammation in Renal Patients August 2009 August 2015
NCT01098448 Completed Phase 3 Control of Periodontal Infections September 1999 December 2004
NCT01140945 Completed Association Study Between Periodontal Disease and Male Infertility
NCT01217281 Completed N/A The Effect of Non-surgical Periodontal Treatment in the Renal Function of Patients With Chronic Kidney Disease: RCT June 2010 May 18, 2022
NCT01229631 Completed N/A The Effect of Daily Dietary Intake of Dried Juice Concentrates of Fruit, Vegetables and Berries Upon Outcomes of Chronic Periodontitis May 22, 2017 September 27, 2017
NCT01234948 Completed Oral Malodour and Periodontal Disease-related Parameters January 2008 September 2009
NCT01271231 Completed N/A Study on Periodontal Treatment in Diabetic Patients April 2010 October 2012
NCT01411618 Completed N/A Efficacy of Essential Oil Mouthwash With and Without Alcohol: a 3-Day Plaque Accumulation Model June 2010 December 2010
NCT01522131 Completed N/A Effect of Laser Use on Guided Tissue Regeneration in Treatment of Molar Teeth With Class 2 Furcation Affected by Periodontitis December 2011 June 2013
NCT01530126 Completed N/A Platelet Derived Growth Factor Stimulates Bone Fill and Rate of Attachment Level Gain January 2000 January 2007
NCT01538927 Completed Phase 4 Effect of Fibrin Sealant on Early Wound Healing April 2012 December 2012
NCT01548469 Completed Phase 4 Study to Evaluate Clinical Efficacy and Safety of Bio Mineral Toothpaste in Patients With Mild Periodontitis March 2012 June 2012
NCT01584479 Completed Periodontal Disease Prevention Study December 2010 March 2012
NCT01593540 Completed Phase 4 Clinical Examination of Metal Free Interdental Brushes September 2010 September 2011
NCT01658475 Completed P. Gingivalis IgG Titer Test for Periodontitis January 2007 March 2010
NCT01750528 Completed Prevalence and Progression of Periodontitis in Ankylosing Spondylitis September 2012 May 2014
NCT00010634 Completed Phase 2 Complementary Naturopathic Medicine for Periodontitis September 1999 July 2004
NCT00066001 Completed Phase 2 Microbial Associations in Periodontal Health and Disease December 2002 December 2009
NCT00066027 Completed Phase 3 Effects of Low-Dose Doxycycline on Oral Bone Loss June 1, 2002 October 1, 2005
NCT00066066 Completed Phase 2 Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers July 2003 July 2009
NCT00066131 Completed Phase 3 Obstetrics and Periodontal Therapy (OPT) Study March 2003 February 2006
NCT00097656 Completed N/A MOTOR: Maternal Oral Therapy to Reduce Obstetric Risk February 2004 May 2010
NCT00155571 Completed The Occurrence of Periopathogens in Betel-Nut Chewers and the Effects of Areca-Nut on Periopathogens August 2001
NCT00199290 Completed Phase 2 A Phase2 Clinical Trial of Trafermin in Patients With Marginal Periodontitis in Japan August 2005 December 2007
NCT00226148 Completed Early Phase 1 Immediate Implant Placement in the Molar Regions September 2005 September 2009
NCT00277706 Completed Phase 1 Impact of Parathyroid Hormone (PTH) on Osseous Cavity August 2004 July 2009
NCT00277745 Completed Integrated Microfluidic System for Oral Diagnostics June 2005 June 2007
NCT00297518 Completed Phase 4 Study of Scaling and Root Planing (SRP) With PerioWave vs. SRP Alone in Chronic Periodontitis March 2006 January 2007
NCT00327561 Completed Phase 3 Effect of Intensive Periodontal Therapy on Vascular Function September 2003 March 2005
NCT00336661 Completed Phase 3 PerioWave Re-Treatment Protocol Compared to Scaling and Root Planing (SRP) and a Single Treatment With PerioWave January 2006 December 2006
NCT00371332 Completed Phase 3 Effect of Adjunctive Treatment With Arestin on the Subgingival Microflora in Patients With Moderate to Advanced Periodontitis January 2004
NCT00425451 Completed Phase 2 The Efficacy and Safety of PerioChip Plus (Flurbiprofen/Chlorhexidine) Formulation in the Therapy of Adult Periodontitis August 2008 March 2009
NCT00514657 Completed Phase 2 Trial in Periodontal Tissue Regeneration Using Fibroblast Growth Factor-2 December 2001 February 2004
NCT03003624 Completed Phase 3 Comparing the Outcomes of Incisions Made by Colorado® Microdissection Needle March 2015 August 2016
NCT03027050 Completed N/A T-PRF Provides Advantages on Periodontal Healing: A Split Mouth Clinical Study November 2015 November 2016
NCT03030820 Completed N/A Oral Gut Liver Axis in Cirrhosis October 2016 March 2018
NCT03069079 Completed N/A Investigation of Dental Health in Children With Neutrophil Defects: A Clinical Study December 2016 December 2019
NCT03072342 Completed N/A PERIODONTITIS AND VASCULAR DYSFUNCTION April 16, 2013 March 30, 2020
NCT03074565 Completed N/A Ultrasonic Versus Ultrasonic+ for Effective Sanative Therapy May 1, 2017 February 5, 2019
NCT03084484 Completed N/A Kiwifruit Effect on Periodontal Inflammation Kiwifruit Effect on Periodontal Inflammation May 2013 May 2016
NCT03087266 Completed N/A Acute-phase Response & Periodontal Treatment in Diabetes Affected Patients June 1, 2016 November 2020
NCT03103204 Completed Phase 4 Treatment of Periodontitis in Obese Individuals January 21, 2017 December 28, 2017
NCT03117153 Completed N/A Effect of a Liquid Toothpaste on Periodontal Disease August 4, 2014 February 11, 2015
NCT03119831 Completed N/A Effectiveness of Three Different Mouthrinses in Dental Plaque Control and Early Wound Healing November 2015 July 2016
NCT03122990 Completed N/A Acute-phase Response & Periodontal Treatment in Patients With Hypertension June 1, 2016 June 30, 2019
NCT03144973 Completed N/A Periodontitis and Upper gi Post-operative Complications May 2, 2017 June 30, 2020
NCT03146975 Completed N/A Effects of Gum Disease Treatment on Host Defense Factors March 2, 2014 June 28, 2017
NCT03148483 Completed N/A Calcium-vitamin D & Periodontal Therapy for Improving Metabolic and Inflammatory Profile Among Pregnant Women April 24, 2017 May 30, 2018
NCT03169920 Completed N/A Efficacy of PRF With M-MIST in the Treatment of Intrabony Defects November 30, 2016 March 31, 2018
NCT03196648 Completed N/A Randomized Trial of a Gum Health Formulation May 1, 2015 November 30, 2016
NCT03225950 Completed Interaction Between Immune Cells and Bacteria Associated With Periodontitis February 1, 2017 March 23, 2020
NCT03268473 Completed N/A Effect of Non-surgical Periodontal Treatment on Oxidative Stress and Antioxidant Status in OSAS July 1, 2017 November 1, 2023
NCT03270254 Completed N/A Photodynamic Therapy Plus Root Debridement in Gum Disease Treatment V2 October 13, 2017 September 19, 2018
NCT03295461 Completed N/A Emblica Officinalis Irrigation in Periodontitis March 2013 October 2014
NCT03311906 Completed Phase 4 Evaluation of the Efficacy of 0.8% Hyaluronic Acid Gel February 15, 2017 October 2, 2017
NCT03354312 Completed Phase 4 Acceptance and Preference of Lidocaine Gel Compared to Injection Anesthesia After Non Surgical Periodontal Treatment December 5, 2017 November 2, 2018
NCT03365167 Completed N/A Clinical Evaluation of the Effect of LANAP as an Adjunct Treatment in Management of Patients With Chronic Periodontitis December 30, 2017 March 30, 2019
NCT03374176 Completed Phase 3 Efficacy of Amoxicillin-metronidazole Compared to Clindamycin in Patients With Periodontitis and Diabetes March 2014 September 2017
NCT03375372 Completed N/A Effects of Periodontal Therapy on Markers of Acute Phase Response, Oxidative Stress April 11, 2003 June 4, 2005
NCT03408548 Completed Phase 2 Effects of Probiotic Therapy in the Treatment of Periodontitis. December 1, 2015 August 30, 2016
NCT03410602 Completed Phase 1 Nonsurgical Periodontal Therapy on Banded First Molars April 1, 2016 November 29, 2017
NCT03423836 Completed Maternal Oral Therapy to Reduce Obstetric Risk Kids April 30, 2007 January 11, 2013
NCT03426241 Completed Effect of Smoking on the Expression of Gelatinases in Chronic Periodontitis February 10, 2010 December 30, 2012
NCT03453476 Completed N/A Effect of Photodynamic Therapy on Gingival Crevicular Cytokines in Periodontitis Patients January 1, 2012 June 30, 2013
NCT03470987 Completed The Role of Visfatin in Obesity and Periodontal Disease October 2013 September 2014
NCT03474146 Completed N/A Comparative Evaluation of Antiplaque and Antigingivitis Efficacy of Ocimum Sanctum (Tulsi) Extract April 12, 2017 July 31, 2017
NCT03509233 Completed N/A Anti-infectious Therapy of Periodontitis - Comparison of Different Clinical Strategies March 1, 2017 August 27, 2020
NCT03542630 Completed Evaluation of Matrix Metalloproteinase 8 Salivary Test for Diagnosis of Periodontitis January 1, 2018 May 1, 2021
NCT03556163 Completed N/A Modified Vertical Internal Mattress Suture Versus Simple Loop Interrupted Suture. December 1, 2016 March 31, 2018
NCT03567161 Completed N/A Ultrasonic Surgical Aspirator to Treat Deep Infrabony Defects February 1, 2017 September 1, 2017
NCT03599401 Completed N/A Effect of Aspirin Vs Omega 3 Fatty Acid After Scaling and Root Planing in Type II Diabetic Patients With Chronic Periodontitis October 15, 2016 March 21, 2017
NCT03614871 Completed Snuff Use, Smoking, Periodontal Health and Premature Death: 30-year Study January 1, 2016 July 13, 2018
NCT03629288 Completed N/A Efficacy of Azithromycin as an Adjunct to Non-Surgical Periodontal Treatment March 1, 2016 October 30, 2016
NCT03639636 Completed N/A is the Sclerostin Marker of Chronic Periodontitis June 1, 2017 May 15, 2018
NCT03652558 Completed N/A Effects of Ozone Therapy as an Adjunct to Periodontal Treatment January 10, 2017 February 10, 2018
NCT03670979 Completed N/A Periodontal Osseous Wall Piezosplitting and EDTA Root Surface Etching January 5, 2016 January 5, 2017
NCT03671408 Completed Levels of High-Sensitivity C-Reactive Protein in Heart Transplant Patients April 20, 2016 June 10, 2018
NCT03690479 Completed N/A The Impact of a Modified Probe Tip Design on Patient Perception of Discomfort on Probing and Clinical Parameters Using the Florida Probe® System April 4, 2013 December 14, 2017
NCT03716154 Completed N/A Clinical Effectiveness of Diode Laser as an Adjunct in the Treatment of Periodontitis April 1, 2017 April 30, 2018
NCT03726411 Completed N/A The Effect of Non-surgical Periodontal Therapy on the Gingival Crevicular Fluid Levels of Prolactin Hormone in Patients With Periodontitis. November 1, 2018 February 1, 2019
NCT03754010 Completed Phase 1 Does Hyaluronic Acid Affect Periodontal Treatment? August 30, 2017 September 30, 2018
NCT03767023 Completed Clinical and Microbiological Relationships Between Periodontitis and Abdominal Aorta Aneurism: an Case Control Study February 2015 March 2018
NCT03779763 Completed Prevalence Of Periodontitis Stage III & IV June 15, 2019 September 15, 2019
NCT03839719 Completed N/A OSE as a Pre-procedural Mouth Rinse: A Clinical and Microbiological Study. January 9, 2019 May 25, 2019
NCT03880448 Completed N/A Metronidazole vs Placebo as Adjuncts to Periodontal Surgery for Patients Positive to Porphyromonas Gingivalis September 19, 2012 January 15, 2018
NCT03901066 Completed Smoking Dependence and Periodontitis September 3, 2014 July 2015
NCT03918902 Completed Snuff Use, Smoking, Periodontitis and Mortality: 30-year Cohort Study From Sweden January 1, 2016 April 1, 2018
NCT03919006 Completed N/A Netrin 1 and Its Receptor Unc5b as Markers of Periodontal Disease January 1, 2018 April 1, 2019
NCT03923218 Completed Effects of Smoking and Vitamin D3 on the Levels of Human Cathelicidin Peptide LL-37 December 2011 July 2015
NCT03928080 Completed Diagnostic Accuracy of Rapid Non-clinical Screening Tests for Early Detection of Periodontitis September 1, 2019 December 31, 2020
NCT03958461 Completed N/A Connection Between Periodontitis and Exudative Age-related Macular Degeneration January 1, 2020 December 7, 2022
NCT03960216 Completed N/A Effects of Periodontal Therapy in Patients With Metabolic Syndrome November 28, 2012 July 2, 2018
NCT03964428 Completed Serum Ferritin and Hepicidin Concentration in Chronic Periodontitis Patients With T2DM September 1, 2018 January 30, 2019
NCT04020146 Completed PPAR, RXR, and VDR Expressions in Peri-implantitis January 10, 2018 March 10, 2019
NCT04032132 Completed Phase 4 Curcumin Paste as an Adjunctive Therapy in Periodontitis August 20, 2016 November 5, 2018
NCT04036890 Completed Phase 4 Local Minocycline in Patients Under Supportive Periodontal Therapy June 3, 2016 October 18, 2019
NCT04044417 Completed Phase 4 Curcumin-Simvastatin-EDTA in the Treatment of Periodontitis August 25, 2016 October 3, 2018
NCT04051385 Completed N/A Assesment of Gingival Crevicular Fluid and Serum ErbB4/Neuregulin-4 Levels in Periodontal Disease and Health April 2, 2018 January 18, 2019
NCT04053660 Completed N/A Effect Of Non-Surgical Periodontal Treatment On Lipoxin a4 Levels October 1, 2017 December 31, 2018
NCT04061460 Completed N/A Periodontal Treatment in Non Smokers, Former Smokers and Smokers September 1, 2014 July 1, 2016
NCT04093895 Completed Phase 2 Trial to Evaluate Safety, Tolerability, Efficacy of PerioSept® as Adjunct to SRP in Subjects With Periodontitis August 26, 2019 September 25, 2020
NCT04129814 Completed N/A The Effects of Non -Surgical Periodontal Treatment on The Severity of Erectile Dysfunction April 2016 July 2017
NCT04137419 Completed N/A Probiotics as Adjunct to Nonsurgical Periodontal Treatment November 11, 2018 April 30, 2020
NCT04149405 Completed Phase 4 Alterations of GCF Levels of Sclerostin and DKK-1 in Postmenopausal Osteoporosis June 30, 2016 December 28, 2018
NCT04178590 Completed Phase 4 Effect of Injectable Platelet-Rich Fibrin (i-PRF) in Initial Treatment of Chronic Periodontitis October 2, 2019 July 9, 2020
NCT04192188 Completed Supportive Periodontal Therapy Under Antiresorptive Therapy December 6, 2019 December 30, 2021
NCT04245982 Completed PPAR, RXR, and VDR Expressions in Diabetes January 1, 2019 December 31, 2019
NCT04254770 Completed N/A At-Home Care for Subjects With Periodontitis January 6, 2020 August 10, 2020
NCT04259242 Completed N/A SRP, Systemic Inflammation and Serum Bone Resorption Markers Premenopausal Women With Periodontitis and Low BMD January 1, 2020 January 31, 2022
NCT04260880 Completed Periodontal Assessment in Depression Patients January 1, 2020 November 30, 2021
NCT04261491 Completed N/A Impact of SRP on Bone Resorption and Systemic Inflammatory Markers in Postmenopausal Women With Periodontitis December 1, 2019 December 30, 2021
NCT04299477 Completed N/A THE EFFETCS OF NON-SURGICAL PERIODONTAL TREATMENT ON SALIVARY BIOMARKERS OF PATIENTS WITH OSTEOPOROSIS AND PERIODONTITIS June 30, 2018 May 30, 2019
NCT04305171 Completed Effect of Non-surgical Periodontal Treatment on Cardiovascular Risk Markers April 6, 2018 February 20, 2020
NCT04349878 Completed N/A Anaysis of Phytotherapy Agent Against Periodontitis September 1, 2019 March 5, 2020
NCT04350489 Completed IL-32 Isoforms Levels in GCF and Plasma of the Patients With Periodontitis October 1, 2017 May 1, 2019
NCT04353362 Completed Phase 4 Alternative Antibiotic Regimen in Periodontitis Treatment April 1, 2017 March 10, 2020
NCT04361630 Completed Early Phase 1 Recombinant Human Fibroblast Growth Factor-2 (rhFGF-2) In Gingival Recession Defects May 1, 2019 December 1, 2019
NCT04368650 Completed Phase 2 RhBMP-2 in Intrabony Defects - A Randomized Controlled Trial December 5, 2017 October 11, 2019
NCT04372420 Completed N/A Bone Morphogenetic Protein-2 In Grade II Furcation Defects. December 5, 2017 October 10, 2019
NCT04382261 Completed N/A Impact of Periodontal Bacteria at Baseline on the Effectiveness of Periodontal Therapy June 5, 2018 March 15, 2020
NCT04383561 Completed N/A Relationship Between LRG and Periodontal Disease September 30, 2019 February 15, 2020
NCT04389931 Completed N/A Effect of Omega 3 as an Immunomodulator Adjunct to Periodontal Debridement March 2016 October 2016
NCT04390997 Completed N/A Determination of the Levels of Lipocalin-2 and Semaphorin3A November 15, 2019 January 15, 2021
NCT04402996 Completed Meteorin-like Levels in Individuals With Periodontitis September 23, 2020 March 3, 2021
NCT04404335 Completed The Role of Anti-inflammatory Cytokines and Antimicrobial Peptide LL-37 Biomarkers in the Treatment of Periodontal Disease. May 17, 2021 July 15, 2022
NCT04417478 Completed N/A Effect of Periodontal Debridement on Leptin Levels in Obese December 2016 July 2019
NCT04430764 Completed N/A The Effect of Smoking and Non-surgical Periodontal Treatment on Gingival Crevicular Fluid Cyclophilin A and EMMPRIN Levels October 2014 August 2015
NCT04449393 Completed N/A Enamel Matrix Derivative in Non-surgical Periodontal Treatment September 15, 2020 July 1, 2022
NCT04477395 Completed N/A Omega-3 Polyunsaturated Fatty Acids in Non-surgical Treatment of Periodontitis November 1, 2017 September 30, 2021
NCT04493398 Completed N/A Air-polishing or Conventional Treatment June 1, 2015 December 1, 2018
NCT04496570 Completed N/A Resolvin D1 Levels in Patients With Periodontitis July 31, 2019 February 29, 2020
NCT04520438 Completed N/A L-PRF Plus Non Surgical Periodontal Treatment October 30, 2019 May 30, 2020
NCT04527913 Completed N/A Interdental Plaque Reduction and Periodontitis September 2011 August 2020
NCT04605289 Completed Phase 1/Phase 2 Levels of Matrix Metalloproteinase-8 After Intrapocket Treatment in Moderate Periodontitis Patients. January 13, 2020 October 14, 2020
NCT04629313 Completed GCF Levels of IL-1Beta, MIP-1 Alfa and G-CSF in Gingivitis and Stage I-II-III-IV Periodontitis Patients July 1, 2020 October 30, 2020
NCT04642716 Completed N/A Evaluation of Free Aminoacids in Saliva as A Diagnostic Biomarker of Periodontal Disease April 20, 2015 August 3, 2017
NCT04653714 Completed N/A The Effects of Non-surgical Periodontal Therapy in Patients Indicated for Bariatric Surgery June 1, 2020 November 30, 2021
NCT04658615 Completed N/A Periodontal Treatment in Rheumatoid Arthritis Patients January 1, 2019 June 30, 2021
NCT04662216 Completed N/A Clinical and Microbiological Efficacy of Chloramine and Hyaluronic Acid Gels in Non-surgical Periodontitis Treatment October 4, 2019 May 1, 2022
NCT04663165 Completed N/A Biomarkers for Periodontitis Relapse February 4, 2010 January 12, 2015
NCT04671394 Completed N/A Diode Laser and Green Indocyanine in the Non-surgical Treatment of Periodontitis October 12, 2015 September 3, 2018
NCT04683016 Completed Disease Perception and Oral Health Impact Profile (OHIP) Before and After Non-surgical Periodontal Treatment June 1, 2020 September 1, 2020
NCT04689438 Completed GCF Levels of IL-1β and IL-6 in Gingivitis and Stage III-Grade C Periodontitis October 8, 2020 December 28, 2020
NCT04694222 Completed N/A Use of Laser Assisted New Attachment Procedure and Low Level Laser Therapy for Periodontitis Patients October 2, 2017 June 15, 2018
NCT04702334 Completed N/A Hyaluronic Acid for Residual Periodontal Pockets Adjunctive Treatment January 2016 November 2018
NCT04712630 Completed N/A Non-Incised Papillae Surgical Approach (NIPSA) With and Without Graft September 9, 2019 December 30, 2020
NCT04735692 Completed N/A Effectiveness of Periodontal Therapy on Periodontal Bacteria February 5, 2021 December 5, 2022
NCT04739475 Completed N/A Effect of Stress on Periodontal Therapy (NPT) March 1, 2021 December 20, 2021
NCT04743336 Completed The Relationship Between Body Mass Index and Periodontitis January 1, 2019 February 1, 2021
NCT04768530 Completed Phase 2 Nitazoxanide as a New Local Adjunctive to Nonsurgical Treatment of Moderate Periodontitis July 20, 2019 April 30, 2020
NCT04769271 Completed Phase 2 Intra-pocket Application of Tea Tree Oil Gel in the Treatment of Stage-2 Periodontitis November 10, 2019 August 25, 2020
NCT04772508 Completed N/A Effect of Amnion Membrane With and Without Taurine on GCF TNF α Level. December 1, 2020 March 13, 2021
NCT04785235 Completed Neutrophil Elastase, Elastase Alpha-1 Proteinase, Periodontitis, Gingival Crevicular Fluid and Acute Coronary Syndrome October 15, 2007 October 15, 2008
NCT04792372 Completed N/A Evaluation of the Effects of Immune Cells on Periodontal Healing February 23, 2021 June 30, 2022
NCT04792541 Completed N/A Hyaluronan in the Treatment of Residual Pockets in Periodontitis Patients. December 2016 February 8, 2021
NCT04806971 Completed Vitamin D Receptor, Interleukin-1A and Interleukin-1B Gene Polymorphisms in Periodontitis January 29, 2018 September 27, 2019
NCT04826926 Completed N/A Timing of Periodontal Re-evaluation After Non-surgical Periodontal Therapy April 1, 2021 January 10, 2022
NCT04827693 Completed The Cortical Shield for Facial Bone Reconstruction January 3, 2019 April 5, 2021
NCT04830969 Completed Phase 2 Impact of Periodontal Therapy on Patients With Diabetes November 8, 2016 January 28, 2021
NCT04836078 Completed Early Phase 1 Role of Simvastatin Microsponges in Treatment of Periodontitis February 10, 2020 October 10, 2020
NCT04846166 Completed I-Smads in Periodontitis August 1, 2019 March 1, 2020
NCT04881357 Completed N/A Antiplaque/Antigingivitis Effect of Lacer Oros Integral September 4, 2021 July 10, 2022
NCT04891627 Completed Gingival Crevicular IL-34 and CSF-1 Levels in Patients With Periodontitis and Uncontrolled Type 2 Diabetes January 6, 2021 May 4, 2021
NCT04913909 Completed N/A Effects of a Probiotic on Oral Microbiota and Glycemic Control in Type 2 Diabetics; A Randomized Clinical Trial September 10, 2015 March 14, 2018
NCT04926519 Completed Periodontitis in Young Individuals, Follow up of Treatment and Disease Progression Over 10 Years October 1, 2018 August 15, 2020
NCT04964167 Completed Phase 4 Indocyanine-green Mediated Photosensitizer VS Aloe Vera Gel: Adjunct Therapy to Scaling and Root Planing in Patients With Chronic Periodontitis September 7, 2021 February 28, 2022
NCT04971642 Completed N/A Intraoral Ultrasound Imaging of Tooth-periodontium Complex February 10, 2021 January 15, 2023
NCT04974502 Completed N/A The Influence of Smoking in Periodontitis Patients, Before and After Nonsurgical Treatment June 2016 March 2019
NCT04982302 Completed Gut Microbial Changes After Periodontal Treatment May 1, 2021 February 1, 2023
NCT04983849 Completed Phase 4 Evaluation of Metronidazole Hydrogel 25% in Stage II and III Periodontitis July 7, 2021 July 7, 2021
NCT05005923 Completed N/A Effect of Periodontal Therapy on Biomarkers in Periodontitis January 23, 2019 July 24, 2020
NCT05038540 Completed N/A The Effect of Virtual Reality Glasses on Dental Anxiety Control October 8, 2021 December 23, 2021
NCT05042024 Completed Phase 3 Supplementation With L-ornithine But Not L-arginine Increases Density of CD68+ and CD163+ Macrophages in Periodontitis October 20, 2017 November 1, 2018
NCT05046678 Completed miRNAs in Periodontal Disease March 1, 2019 November 1, 2020
NCT05073107 Completed N/A The Effect of A Dental Application to Promote Self-Administered Plaque Control: A RCT December 6, 2021 January 14, 2022
NCT05099731 Completed Diagnostic Accuracy of Matrix Metalloproteinase-8 Test for the Discrimination of Periodontal Health and Disease October 10, 2021 December 30, 2021
NCT05101434 Completed Gingivitis and Periodontitis as a Risk Factor for Stroke January 10, 2021 July 20, 2021
NCT05101603 Completed N/A Effects of Nd:YAG Laser and Air Abrasive Combined Application in Patients With Periodontitis September 1, 2019 September 1, 2020
NCT05112471 Completed N/A Efficacy of GBT vs SRP+US, in the Treatment of Severe Generalized Periodontitis. November 22, 2016 April 4, 2020
NCT05114681 Completed Oral Health Care in Stroke Patients in Tertiary Care Hospital January 1, 2021 June 30, 2021
NCT05115201 Completed N/A Effect of Antibiotics on Systemic Inflammation November 26, 2021 June 10, 2022
NCT05120206 Completed N/A The Impact of Cigarette Smoking on Periodontal Therapy April 1, 2012 March 1, 2015
NCT05125718 Completed Early Phase 1 Clinical and Metagenomic Investigation of Antimicrobial Peptide Gel in Periodontal Treatment. January 1, 2021 April 30, 2021
NCT05137392 Completed N/A Effect of Novel Oral Hygiene Regimen on Non-surgical Treatment of Stage II and III Periodontitis February 1, 2022 October 15, 2023
NCT05140681 Completed N/A Influence of Flap Position Following FibReORS September 1, 2017 December 23, 2018
NCT05174494 Completed N/A Impact of Periodontal Treatment on NT-proBNP Levels January 2, 2020 November 30, 2022
NCT05178771 Completed N/A Efficacy of PRF Application on Clinical Parameters and GCF Platelet-derived Growth Factor-BB and Periostin Levels March 1, 2022 September 25, 2022
NCT05202132 Completed Masticatory Function in the Differential Diagnosis of Stage IV Periodontitis October 1, 2020 June 30, 2021
NCT05225142 Completed N/A 10 Year Follow up of RCT Comparing Different Regenerative Regenerative Procedures January 1, 2007 March 31, 2020
NCT05242354 Completed Macrophage Markers in Periodontal and Peri-implant Health and Disease March 1, 2021 December 31, 2021
NCT05258721 Completed Phase 2 Efficacy of ClōSYS® Sensitive Fluoride Toothpaste and ClōSYS® Sensitive Rinse Regimen on MGI, PI and BOP July 6, 2021 October 31, 2022
NCT05271890 Completed N/A Rheumatoid Arthritis and Treatment of Periodontitis: a Randomized Clinical Trial. August 25, 2014 February 2019
NCT05278468 Completed Association Between Periodontitis and Coronavirus Disease (COVID-19) August 15, 2022 October 15, 2022
NCT05281848 Completed N/A Effect of Smoking and Periodontal Therapy on Salivary and Gingival Crevicular IL-17 and IL-35 January 1, 2018 March 7, 2022
NCT05306860 Completed IL-6, IL-17 and IL-35 Levels in the Gingival Crevicular Fluid of Patients With Periodontitis and Healthy Controls April 15, 2022 June 30, 2023
NCT05307068 Completed IL-10, IL-12 and IL-18 Levels in the Gingival Crevicular Fluid of Patients With Periodontitis and Healthy Controls April 15, 2022 June 30, 2023
NCT05317208 Completed Prevalence of Periodontitis in Sample of Egyptian Population May 5, 2019 March 1, 2022
NCT05343273 Completed 25-Hydroxyvitamin D Levels in Patients With Periodontitis (Stage III) March 10, 2022 May 10, 2022
NCT05354986 Completed N/A Impact of a Newly Formulated Toothpaste in Tooth Staining Associated With Chlorhexidine Rinses October 1, 2022 January 31, 2024
NCT05361590 Completed N/A Impact of Regular Home Use of Lumoral Dual-light Photodynamic Therapy on Plaque Control and Gingival Health October 11, 2022 August 16, 2023
NCT05395455 Completed N/A Gingival Crevicular Fluid, Salivary, and Serum Biomarkers Levels in Periodontal Treatment November 12, 2018 January 23, 2020
NCT05417061 Completed N/A Serum and Saliva Sirtuin 6, Lipoxin A4, Caspase8 Levels in Correlation With Periodontal Status in Severe Periodontitis October 14, 2021 May 30, 2022
NCT05447026 Completed N/A The Effect of Adjunctive Therapies in Regenerative Treatment of Stage III Grade C Periodontitis January 1, 2018 September 15, 2022
NCT05448976 Completed N/A Potential Effect for the Smoking on Periodontitis From the Perspective of Arginine Metabolites August 12, 2021 May 16, 2022
NCT05449093 Completed GCF Galectin-3 and Interleukin-1beta Levels in Periodontitis. February 21, 2019 September 2, 2019
NCT05449249 Completed N/A Oral and Gut Microbiota Changes During Long-term Fasting in Humans September 1, 2022 January 6, 2023
NCT05449821 Completed Investigation of Asprosin a Novel Adipokine in Periodontitis January 1, 2022 December 1, 2022
NCT05454059 Completed N/A Salivary C1P and PGE2 Levels in Periodontitis Patients With T2DM and Effect of Non-Surgical Periodontal Treatment October 22, 2020 June 22, 2022
NCT05474820 Completed N/A Saliva Irisin Level is Higher and Related With Interleukin 6 in Generalized Periodontitis February 24, 2022 July 19, 2022
NCT05484765 Completed Effects of Smoking on Oral Tissue Samples November 1, 2018 July 20, 2019
NCT05506098 Completed Investigating STAT3 as a Driver of Pathology in Periodontitis March 20, 2019 October 20, 2022
NCT05506371 Completed N/A Effects of Azithromycin as an Adjunct to Scaling and Root Planning in the Treatment of Periodontitis September 16, 2017 June 28, 2019
NCT05530252 Completed Phase 4 Effects of AMP Application After Non-surgical Periodontal Therapy on Treatment of Periodontitis September 5, 2022 January 30, 2023
NCT05558293 Completed N/A Impact of Periodontal Bacteria on the Effectiveness of Periodontal Therapy June 1, 2022 December 5, 2022
NCT05583643 Completed Phase 1 Clinical & Biochemical Effect of Atorvastatin in Nano Particles Gel in Periodontitis Treatment December 7, 2021 June 30, 2022
NCT05608564 Completed N/A Local and Systemic Antimicrobials in Non-surgical Periodontal Therapy January 17, 2022 May 30, 2023
NCT05631288 Completed Association of Herpesvirus and Periodontitis March 1, 2019 February 1, 2022
NCT05653245 Completed Phase 1/Phase 2 The Use of Adhesion Molecule Loaded Hydrogel With Minimally Invasive Surgical Technique in Treatment of Periodontal Intrabony Defect March 15, 2021 September 9, 2022
NCT05656989 Completed GCF PLAP-1, Sclerostin and TNF-α Levels in Periodontitis September 20, 2020 June 15, 2021
NCT05657015 Completed Phase 4 Lepidium Sativum Extract Versus Simvastatin as an Adjunctive Local Delivery Agents to Non-Surgical Periodontal Therapy September 1, 2021 July 1, 2022
NCT05662475 Completed N/A Effect of Periodontal Treatment on Visfatin, fetuin-a and Sirtuin 1 of Patients With Periodontitis and Type 2 Diabetes November 15, 2021 July 15, 2022
NCT05666622 Completed N/A DNI Values After Periodontal Treatment October 1, 2020 January 1, 2022
NCT05667051 Completed Endocan Biomarker Level in Gingival Crevicular Fluid in Periodontitis Patients With Type 2 Diabetes Mellitus April 5, 2022 September 10, 2022
NCT05667376 Completed N/A Efficacy of Curcumin Gel Combined With Non-surgical Periodontal Therapy on Salivary Procalcitonin Level in the Treatment of Periodontitis Patients January 1, 2021 May 30, 2021
NCT05680441 Completed GCF Annexin-A1, Carbonic Anhydrase-1, and Elongation Factor-1 Gamma Levels in Periodontitis September 1, 2022 December 16, 2022
NCT05684627 Completed N/A The Application of a Fasting- Mimicking Diet in Periodontitis: A Feasibility Study March 15, 2023 January 15, 2024
NCT05724251 Completed Effect of Iodine Deficiency on Periodontitis October 30, 2021 November 30, 2022
NCT05741970 Completed N/A Interaction Between Hypertension and Periodontitis January 2, 2017 June 25, 2018
NCT05757921 Completed N/A Comparison of Adjunctive Chemomechanical Therapy With Standard Care in Patients With Periodontitis October 24, 2011 May 16, 2014
NCT05765513 Completed N/A HA35 Treatment the Gingival Discomfort as Well as Gingival Redness and Bleeding of Patients With Periodontitis February 2, 2023 August 11, 2023
NCT05770258 Completed N/A The Novel Electrolyzed Water Spray Treatment Mild Periodontitis January 29, 2023 January 20, 2024
NCT05783011 Completed N/A The Effects of Electroacupuncture on Postoperative Pain March 30, 2021 December 30, 2022
NCT05812300 Completed N/A Local Injection of Periodontal Pocket Method for the Treatment of Gingivitis June 1, 2023 February 20, 2024
NCT05816941 Completed N/A Antimicrobial Photodynamic Therapy in Patients With Periodontal Disease and Type 2 Diabetes Mellitus January 3, 2016 January 3, 2019
NCT05834517 Completed Phase 4 ''Efficacy of Locally Delivered Hyaluronic Acid Gel as an Adjunctive to Non-Surgical Management of Periodontitis May 2, 2022 December 10, 2022
NCT05836298 Completed N/A Impact of C-reactive Protein on Non Surgical Periodontal Treatment January 2, 2022 May 30, 2023
NCT05866497 Completed Arterial Stiffness in Type 2 Diabetic Patients With Severe Periodontitis June 10, 2022 January 21, 2023
NCT05870358 Completed Phase 4 Melatonin Supports Non Surgical Periodontal Treatment in Patients With Type 2 Diabetes and Periodontitis February 18, 2021 June 18, 2022
NCT05905445 Completed Phase 1 Use of Ozone Gel as an Antimicrobial in Treatment of Periodontitis March 9, 2022 September 9, 2022
NCT05906797 Completed N/A Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Periodontitis. September 7, 2020 December 12, 2023
NCT05908929 Completed N/A PRF Therapy for Pocket Reduction September 15, 2022 February 15, 2023
NCT05924828 Completed sTREM-1, sTREM-2, Presepsin, and Periodontitis August 1, 2023 December 1, 2023
NCT05926999 Completed Conversational AI Models in Periodontitis Classification June 25, 2023 July 30, 2023
NCT05936450 Completed Phase 4 Assessment Of Healing After Periodontal Flap Surgery With And Without The Use Of Placental Extracts March 4, 2021 January 13, 2023
NCT05952895 Completed Salivary Proteome in Response to Non-surgical Periodontal Treatment July 1, 2018 December 30, 2019
NCT06002997 Completed Periodontal Status and Pregnancy or Delivery Complications in Type 1 Diabetes Mellitus Pregnant Women May 3, 2012 December 1, 2014
NCT06016894 Completed N/A Hydroxyapetite Nanoparticles, Tricalcium Phosphate Nanoparticles, and PRF for Treatment of Gingival Recession September 1, 2000 April 22, 2023
NCT06016933 Completed N/A Effect of Spirulina on Periodontitis July 1, 2022 July 22, 2023
NCT06027151 Completed N/A Comparing the Efficacy of Metronidazole and Minocycline Gels for the Treatment of Diabetic Periodontitis Patients October 6, 2022 July 31, 2023
NCT06028867 Completed N/A Validation of the Clinical and Antimicrobial Effectiveness of a Clorexidine and Sodium DNA Based Mouthwash in Patients With Stage III and IV Periodontitis January 24, 2020 April 20, 2024
NCT06038812 Completed N/A Galectin Role in Periodontal Disease August 1, 2023 September 30, 2023
NCT06050174 Completed Phase 2 Azadirachta Indica (Neem) Extract as an Adjunct to Non-Surgical Periodontal Management September 1, 2021 July 1, 2023
NCT06091800 Completed Interleukin 20 and Periodontal Tisuue Destruction June 6, 2022 June 6, 2023
NCT06103578 Completed Evaluation of SOST, TWEAK, RANKL, OPG Levels in Smokers and Non-Smokers With Periodontitis December 1, 2021 September 4, 2023
NCT06110221 Completed Activin-A and Interleukin-1β Levels in Periodontitis March 22, 2019 February 2, 2020
NCT06119893 Completed N/A The Use of Submucosal Dexamethasone After Periodontal Surgery August 12, 2021 April 29, 2022
NCT06127069 Completed N/A Treatment of Residual Pockets in Periodontal Patients Using an Oscillating Chitosan Device September 8, 2021 November 29, 2022
NCT06128850 Completed Peri-implant Conditions Mimic Periodontal Conditions July 4, 2022 March 31, 2023
NCT06135116 Completed Regulatory T Cell With Related Interleukins in Periodontal Disease Progression November 1, 2023 January 1, 2024
NCT06135532 Completed N/A Chemerin, Fetuin-A, IL-34 and IL-13 Levels in Diabetic Periodontitis Patients October 1, 2018 February 21, 2020
NCT06153706 Completed Phase 2/Phase 3 Evaluation of L-PRF as an Antibiotic Slow-release Biological Device in the Treatment of Moderate Periodontitis June 1, 2022 October 1, 2023
NCT06204185 Completed N/A Clinical and Biochemical Evaluation of 1% Metformin in Non-surgical Treatment of Periodontitis February 1, 2019 November 30, 2022
NCT06209554 Completed N/A The Efficacy of Diode Laser and Subgingival Air Polishing With Erythritol in Treatment of Periodontitis January 13, 2023 March 17, 2023
NCT06214728 Completed N/A Use of Hyaluronic Acid Gel in Intraosseous Defects March 16, 2022 May 12, 2023
NCT06225154 Completed N/A Effect of Periodontal Treatment on Adipokine Levels February 2015 November 2016
NCT06247007 Completed N/A Electroacupuncture as an Adjunct to Non-Surgical Periodontal Therapy August 1, 2023 December 1, 2023
NCT06255470 Completed N/A Effect of Periodontal Treatment on Salivary and Serum Biomarkers in Periodontitis September 1, 2022 November 1, 2023
NCT06287424 Completed N/A The Efficacy Of AGE On Periodontitis April 4, 2021 January 1, 2023
NCT06295666 Completed Gingival Crevicular Fluid (GCF) Bactericidal Permeability Protein (BPI) and Interleukin (IL)-1 Beta February 19, 2019 January 20, 2020
NCT06309797 Completed N/A Effects of Interdental Brush Dipped in 0.2% Hyaluronic Acid Gel on Periodontitis May 2, 2023 February 5, 2024
NCT06326073 Completed N/A Interaction Between Smoking, GCF Periostin, IL17A, IL17E and Non-surgical Periodontal Therapy July 1, 2019 July 1, 2021
NCT06354504 Completed N/A Bactericidal Permeability Protein Inhibitor and Interleukin-1beta Levels After Non-surgical Periodontal Treatment November 19, 2019 September 20, 2020
NCT06383455 Completed Effects of Smoking on Clinical and Microbiological Response in Individuals With Periodontitis September 15, 2018 March 1, 2019
NCT06404190 Completed Phase 1 Diode Laser Photo Activation for Pocket Reduction Decontamination A Clinical Study May 28, 2023 September 15, 2023
NCT06443372 Completed GCF Bax and Bcl-xl Levels in Periodontitis March 22, 2019 April 12, 2024
NCT01812083 Completed Interleukin-1 Receptor Antagonist Gene Polymorphism and Adverse Pregnancy Outcome in Turkish Women January 2004 February 2005
NCT01964833 Completed N/A PDT and Periodontal Treatment in DMT2 Patients October 2013 December 2015
NCT01976806 Completed Phase 2 The Effects of DHA on Periodontitis June 2009 September 2011
NCT02017886 Completed N/A Salivary IgA and Cytokines Response to Dietary Supplementation of Lactobacillus Reuteri November 2013 April 2016
NCT02030470 Completed Phase 4 Evaluation of Photodynamic Treatment FOTOSAN® Efficacy in Periodontology June 2014 March 2018
NCT02039648 Completed Early Phase 1 The Influence of Rumex Acetosa L on the Intraoral Colonization With Porphyromonas Gingivalis March 2012 April 2013
NCT02043340 Completed Phase 2 Single Session Of Antimicrobial Photodynamic Therapy Using Indocyanine Green October 2012 December 2013
NCT02062047 Completed Phase 4 Full-mouth and Partial-mouth Scaling and Root Planing in Type 2 Diabetic Subjects December 2007 April 2010
NCT02081976 Completed Phase 2 Periodontal Therapy in a Primary Prevention of Cardiovascular Disease April 2013 January 2014
NCT02109705 Completed Porphyromonas Gingivalis and Alzheimer's Disease March 2014 January 2021
NCT02119520 Completed Phase 2 PLATELET RICH FIBRIN COMBINED WITH 1.2% ATORVASTATIN FOR TREATMENT OF INTRABONY DEFECTS IN CHRONIC PERIODONTITIS February 2013 February 2014
NCT02124655 Completed Phase 4 Antiplaque Effect of Essential Oils and 0.2% Chlorhexidine on an in Situ Model of Oral Biofilm Growth. September 2012
NCT02149758 Completed Phase 4 EFFECT OF SELECTIVE COX-2 INHIBITOR (ETORICOXIB) ALONG WITH SCALING AND ROOT PLANING (SRP) ON CLINICAL PARAMETERS AND SALIVARY LEVEL OF SUPEROXIDE DISMUTASE IN CHRONIC GENERALIZED PERIODONTITIS A DOUBLE-BLIND, PLACEBO-CONTROLLED, DOUBLE-MASKED RANDOMIZED CONTROLLED TRIAL (RCT). January 2013 June 2013
NCT02150005 Completed N/A Non-surgical Periodontal Treatment on Hemogram, Lipid and Glycemic Profiles in Patients With Coronariopathies January 2009
NCT02154906 Completed N/A Clinical and Radiographic Evaluation of Demineralized Freeze-Dried Bone Allograft Versus Platelet Rich Fibrin for the Treatment of Periodontal Intrabony Defects in Humans November 2013 April 2016
NCT02172716 Completed N/A Disruption of Immune Homeostasis in Type 2 Diabetics With Generalized Chronic Periodontitis May 2014 May 2016
NCT02187185 Completed N/A Salivary Inflammatory Biomarkers: Predictors & Comparative Effects of Sonicare/Elite-Flexcare in Stages of Perio Disease April 2009 March 2012
NCT02215460 Completed Phase 4 Treatment of Periodontitis by Conventional 4 Weekly Sections or Within 24 Hours April 2012 April 2014
NCT02215473 Completed Phase 4 Bacteremia in Periodontal Patients August 2013 December 2013
NCT02220751 Completed Phase 3 Diagnostic Biomarkers Related to Periodontal Disease Activity in Diabetic March 2009 June 2012
NCT02271815 Completed A Clinical and Imaging Study to Evaluate a Novel Dentifrice October 2014 June 2021
NCT02274090 Completed Phase 2/Phase 3 1% Metformin in Moderate and Severe Periodontitis November 2013 August 2014
NCT02283554 Completed Phase 2 Platelet Rich Fibrin With 1% Metformin Gel for Treatment of Intrabony Defects November 2013
NCT02313883 Completed Phase 1/Phase 2 A Phase I/II Study to Evaluate the Safety and Efficacy of PerioSept® as Adjunct to SRP in Subjects With Periodontitis July 2015 July 2, 2018
NCT02337166 Completed Phase 1/Phase 2 Regeneration of Human Intrabony Defects With rhFGF-2/HA December 2002 August 2013
NCT02359721 Completed Phase 4 Clarithromycin is an Adjunct to Scaling and Root Planing January 2012 December 2013
NCT02366585 Completed Phase 2 The Effect of Locally Delivered Ciclosporin as an Adjunct to Healing After Treatment of Periodontal Pockets March 2015 October 2016
NCT02368678 Completed N/A "Study of Halitosis in Patients With Advanced Chronic Periodontitis" April 2013 May 2014
NCT02379975 Completed N/A Evaluation of Non-surgical Periodontal Therapy in Patients With Rheumatoid Arthritis February 2013 November 2014
NCT02390479 Completed Early Phase 1 Gingival Crevicular Fluid Levels of Sclerostin, Osteoprotegerin (OPG) and RANKL in Health, Disease and After Treatment December 2013 October 2014
NCT02403960 Completed N/A Probiotic Use in Chronic Periodontitis Patients June 2010 May 2011
NCT02407379 Completed N/A Diode Laser and SRP in Chronic Periodontitis October 2015 August 28, 2018
NCT02409966 Completed N/A Effect of Periodontitis Treatment on Quality of Life and Experiences of Fear, Anxiety and Pain February 2011 December 2014
NCT02417376 Completed N/A Changes in the Risk Factors of Coronary Heart Disease Observed After Scaling and Root Planing May 2013 October 2014
NCT02418520 Completed N/A The Effect of Miswak Chewing Sticks on the Oral Helicobacter Pylori Infection October 1, 2019 December 1, 2019
NCT02447510 Completed Phase 3 Growth Factors Release of PRF and PRGF September 2014 March 2015
NCT02462993 Completed Phase 2/Phase 3 Local Drug Delivery of Aloe Vera Gel in Chronic Periodontitis February 2014 May 2015
NCT02470611 Completed Phase 4 Sodium Alendronate in Non Surgical Periodontal Therapy November 2012 November 2014
NCT02490618 Completed N/A The Use of a Probiotic Lozenge in the Treatment of Residual Pockets After Classical Non-surgical Therapy January 2016 December 2018
NCT02493270 Completed N/A Effect of Smoking Cessation on Non-surgical Periodontal Therapy May 2007 June 2014
NCT02508987 Completed Obesity and Oxidative Stress in Patients With Different Periodontal Status September 2012 March 2014
NCT02512952 Completed Phase 2/Phase 3 Treatment of Periodontal Intrabony Defects Using Autologous Platelet Rich Fibrin vs Titanium Platelet Rich Fibrin June 2014 March 2015
NCT02521688 Completed Inflammatory Cytokines in GCF and Placental Tissues in Chronic Periodontitis Patients With Preterm Delivery August 2013 August 2015
NCT02538237 Completed Phase 2/Phase 3 the Effect of Sub-gingival Irrigation With Ibuprofen 2% Mouthwash in Treatment of Periodontal Diseases. November 2013 February 2015
NCT02543502 Completed N/A Treatment of Periodontal Disease in Patients With Acute Myocardial Infarction August 2012 January 2015
NCT02546804 Completed N/A A Clinical Trial to Study the Effects of Two Home Made Mouthwashes in Patients With Gum Diseases June 2015 December 2015
NCT02551770 Completed N/A Emdogain Minimally Invasive Surgical Technique October 2015 August 30, 2019
NCT02563171 Completed Early Phase 1 Gingival Crevicular Fluid Vaspin and Omentin Levels in Obese Patients With Chronic Periodontitis July 2014 May 2015
NCT02628197 Completed N/A Effect of Periodontitis on Bone Mineral Density in Postmenopausal Women December 2013 June 2015
NCT02632981 Completed Phase 1 IL-32 Levels in Patients With Chronic Periodontitis July 2014 July 2015
NCT02660814 Completed Early Phase 1 Chemerin and Interleukin-6 Levels of Gingival Crevicular Fluid in Obese Individuals Following Periodontal Treatment July 2014 May 2015
NCT02664675 Completed Cellular and Molecular Inflammatory Mechanisms Leading to Bone Resorption in Peri-implantitis Vs Periodontitis April 2014 January 2016
NCT02671812 Completed Outcome After Dental Implant Treatment November 27, 2014 August 2018
NCT02709785 Completed N/A SmartMouth Advanced Clinical Formula Clinical Research Design Protocol March 2016 May 2017
NCT02718014 Completed Phase 1/Phase 2 Evaluation of Periodontal Response to Non Surgical Therapy in Pre and Post Menopausal Women With Periodontitis January 2015 August 2015
NCT02744417 Completed N/A Effect of Smoking Cessation on Clinical and Microbiological Outcomes of the Non-surgical Periodontal Therapy August 2010 March 2014
NCT02745015 Completed N/A Effect of Non Surgical Treatment of Periodontitis on Diabetes Control December 2014 May 2015
NCT02761668 Completed N/A Timing of Orthodontic Therapy and Regenerative Periodontal Surgery in Advanced Periodontitis Patients With Pathologic Tooth Migration October 2016 March 22, 2023
NCT02764060 Completed Early Phase 1 The Effect of Tongue Cleaning in Periodontitis Patients January 2011 January 2015
NCT02775266 Completed N/A Effect of Antioxidant Intake on Resistin Levels In Patients With Gum Disease and Diabetes February 2016 October 2016
NCT02779179 Completed N/A Therapeutic Management of Periodontitis and Clinical Manifestations of Rheumatoid Arthritis November 2010 November 2016
NCT02788786 Completed Phase 2 Feasibility and Acceptability of Use of Daily Oral Rinse in Pregnant Women in Rural Nepal June 27, 2016 November 15, 2016
NCT02794506 Completed Phase 4 Propolis Improves Glycemic Control in Subjects With Type 2 Diabetes and Chronic Periodontitis June 2014 March 2015
NCT02830113 Completed N/A Metabolic Effects of Treatment of Chronic Periodontitis in Non-diabetic Subjects December 2014 September 2015
NCT02835898 Completed Epigenetics and Periodontal Treatment September 2015 June 2016
NCT02873949 Completed N/A Analysis of Soluble TREM (Triggering Receptor Expressed on Myeloid Cells)-1 and -2 in Crevicular Fluid and Associated Bacterial Flora in Patients Affected by Periodontitis April 2016 December 2017
NCT02894593 Completed N/A Alcohol-free Essential Oils Containing Mouthrinse Efficacy on 3-day Supragingival Plaque Regrowth January 2015 July 2016
NCT02913248 Completed N/A Salivary Bacterial Profiles in Relation to Periodontal Treatment October 2016 January 2, 2017
NCT02921165 Completed Phase 4 Comparison of Topical Analgesic With Saline Rinses in Post Extraction Healing May 2016 June 2016
NCT04971174 Enrolling by invitation Outcomes of Periodontal Regenerative Treatment September 30, 2022 December 31, 2024
NCT05934227 Enrolling by invitation N/A Amoxicillin Plus Metronidazole in Periodontal Maintenance July 1, 2023 September 1, 2024
NCT05932017 Enrolling by invitation Comparison of Gingival Flap Procedure Using Conventional Surgical Loupes vs. Videoscope for Visualization July 1, 2023 March 2025
NCT04781153 Enrolling by invitation N/A Bergen Oral Respiratory Intervention Study April 27, 2021 July 1, 2024
NCT06063460 Enrolling by invitation The Impact of Non-surgical Periodontal Therapy on Patients' Halitosis, Taste Perception, and Smell Sensation October 10, 2023 June 30, 2024
NCT05869981 Not yet recruiting Association Between Periodontal Status and Mental Health in Postpartum Women June 7, 2023 October 7, 2023
NCT06245278 Not yet recruiting N/A The Effect of Non-Surgical Periodontal Therapy on Inflammatory Bowel Disease February 1, 2024 March 1, 2025
NCT05079204 Not yet recruiting N/A Intraoral Scanners as a Motivation Method for Oral Hygiene Instruction May 2023 December 2023
NCT06262035 Not yet recruiting Transcriptome, Proteome and Microbiome Profile in Periodontal and Peri-implant Diseases March 15, 2024 December 31, 2030
NCT06255067 Not yet recruiting Phase 2/Phase 3 Efficacy of Noisome as A Carrier of Locally Delivered Minocycline Hydrochloride Gel February 25, 2024 June 30, 2024
NCT06324474 Not yet recruiting N/A Clinical and Immunological Evaluation of HA in Treatment of Periodontitis April 2024 December 12, 2024
NCT05876455 Not yet recruiting N/A Comparative Evaluation of Minimally Invasive Nonsurgical Periodontal Therapy Versus Conventional Subgingival Instrumentation July 10, 2023 November 10, 2023
NCT05890157 Not yet recruiting N/A Treatment Of Shallow Periodontal Pockets Using PRF As an Adjunct To Scaling And Root Planing In Periodontitis Patients July 30, 2023 December 30, 2023
NCT06116487 Not yet recruiting MRI as Alternative to CBCT for the Assessment of Furcation Involvement in Molars November 20, 2023 December 20, 2024
NCT05502601 Not yet recruiting N/A Periodontal Therapy in Patients With Rheumatoid Arthritis December 15, 2022 May 1, 2025
NCT06091228 Not yet recruiting N/A The Additional Effect of Tongue Scraping on Halitosis Parameters in Initial Periodontal Therapy January 1, 2024 June 1, 2025
NCT06175624 Not yet recruiting N/A Effect of Non-Surgical Periodontal Treatment on Gingival Crevicular Fluid and Serum Biomarker Levels January 1, 2024 November 1, 2025
NCT04602572 Not yet recruiting Obesity and Oral Diseases in Adult Patients August 1, 2024 September 3, 2025
NCT05481567 Not yet recruiting Periodontitis Stage III and IV and Oral Health Related Quality of Life September 1, 2022 June 30, 2023
NCT05459727 Not yet recruiting N/A Effects of Non-surgical Periodontal Therapy on Cardiovascular Risk August 1, 2022 December 31, 2026
NCT06178081 Not yet recruiting N/A Effect of Non-Surgical Periodontal Treatment on Biomarker Levels January 1, 2024 November 1, 2025
NCT06188884 Not yet recruiting Staging and Grading of Periodontitis: Five Years Later June 1, 2024 August 31, 2024
NCT06070181 Not yet recruiting N/A Effectiveness of Adjunctive Therapy of Emdogain®FL in Non-surgical Periodontal Treatment December 1, 2023 June 2026
NCT06063226 Not yet recruiting N/A Clinical and Microbiological Aspects of Probiotics in Non-surgical Periodontal Therapy. October 1, 2023 June 1, 2024
NCT05574231 Not yet recruiting A Danish Nationwide Longitudinal Study on Prevalence of Periodontitis and Its Co-morbidities November 2022 December 31, 2025
NCT05398770 Not yet recruiting N/A Randomized Clinical Trial (RCT) on the Effect of Vitamin D Supplement Prior to Non-surgical Periodontal Therapy: a Feasibility Trial August 2022 December 2024
NCT06371560 Not yet recruiting Antibiotics, Antibiotic Resistance, and Prescribing Practices Among Periodontists: Cross Sectional KAP Study April 25, 2024 October 30, 2024
NCT06319261 Not yet recruiting N/A Efficacy of Guided Biofilm Therapy (GBT) for Treatment of Deep Periodontal Pockets. April 2024 December 2024
NCT06435208 Not yet recruiting N/A Impact of Subgingival Instrumentation on Psychological Distress and Mental Health Status in Bruxers With Periodontitis June 1, 2024 February 1, 2025
NCT05275803 Not yet recruiting N/A Lactobacillus Reuteri for Non-surgical Periodontal Treatment of Chronic Periodontitis With Type 2 Diabetes Patients June 8, 2023 May 20, 2024
NCT06302855 Not yet recruiting N/A Exploring Adherence and Knowledge Among Diabetic Individuals in Periodontal Care March 1, 2024 September 1, 2026
NCT06430450 Not yet recruiting Determination of Salivary Soluble Urokinase Plasminogen Activator Receptor (SuPAR), Hypoxia-inducible Factor-1 Alpha (HIF-1α), E-cadherin, Galectin 3, IL-4, IL-10 and TNF-α Levels in Individuals With Different Degrees of Periodontal Disease July 15, 2024 January 15, 2025
NCT06012019 Not yet recruiting Periodontitis and Inflammation: Study on Biological Samples March 6, 2024 March 13, 2024
NCT06450821 Not yet recruiting N/A PROSpECT-PRIOR-2-CHEMO: PRIOR Dental Intervention Before Chemo to Reduce Chemotherapy Complications July 2024 October 2026
NCT05643287 Not yet recruiting N/A The Effect of Time on the Outcome of Periodontal Treatment. September 2023 December 2023
NCT06453278 Not yet recruiting (DDS) in India: a Screening Tool to Identify Prediabetes and Undiagnosed Type 2 Diabetes in Dental Settings September 2024 April 2026
NCT05681754 Not yet recruiting N/A Endo-perio Disease - Treatment Outcomes Using Conventional and Hydraulic Calcium Silicate Sealer With or Without LPRF May 2023 May 2033
NCT06429917 Not yet recruiting N/A Impact of Subgingival Instrumentation on Jaw Symptoms of Probable Bruxers Among Patients With Periodontitis August 2024 September 2025
NCT05183321 Not yet recruiting N/A Treatment of Periodontal Disease in Patients With Alzheimer's Disease June 1, 2024 December 31, 2026
NCT05568290 Not yet recruiting Interleukin-38 Levels in Individuals With Periodontitis September 30, 2022 December 10, 2022
NCT05569525 Not yet recruiting N/A Type I Diabetes and Non-surgical Periodontal Treatment November 6, 2022 May 10, 2024
NCT05970965 Not yet recruiting N/A Periodontitis and Inflammation in Children With Down Syndrome/Trisomy 21: Study on Biological Samples March 13, 2024 March 13, 2025
NCT06245265 Not yet recruiting N/A The Effect of Non-Surgical Periodontal Therapy on Rheumatoid Arthritis February 1, 2024 March 1, 2025
NCT06270303 Not yet recruiting N/A Use of a Bone Substitute Material in the Surgical Therapy of Furcation Defects March 1, 2024 March 1, 2036
NCT06436729 Not yet recruiting N/A Impact of MINST With and Without Splinting in Periodontitis Patients With Mobile Anterior Teeth June 1, 2024 December 31, 2025
NCT05880303 Recruiting N/A Effect of Nonsurgical Periodontal Therapy (NSPT) on Rheumatoid Arthritis Subjects With Periodontitis January 3, 2023 June 30, 2025
NCT05682833 Recruiting N/A Adjunctive Use Of A Novel Hyaluronic Acid/Chlorhexidine Gel In The Non Surgical Treatment Of Periodontitis October 1, 2022 June 20, 2024
NCT06143085 Recruiting N/A Impact of Nonsurgical Periodontal Therapy on Oral Health Related Quality of Life October 10, 2022 January 20, 2024
NCT05696600 Recruiting N/A Impact of Supracrestal Tissue Attachment Dimension on Outcome of Scaling and Root Planing and Open Flap Debridement Procedure in Different Periodontal Phenotypes February 1, 2023 March 31, 2024
NCT05706675 Recruiting N/A Specialized Pro-resolving Mediators (SPM) as Biomarkers of Periodontal Inflammation October 1, 2022 June 2024
NCT05719519 Recruiting N/A Change in Gingival Volume and Quality of Life Due to Initial Periodontal Therapy in Smokers February 1, 2023 December 31, 2024
NCT06382935 Recruiting N/A Impact of Non-surgical Periodontal Treatment of miRNome April 20, 2024 October 15, 2024
NCT05754307 Recruiting N/A A Closed Surgical Technique vs Papilla Preservation Techniques March 3, 2023 December 30, 2024
NCT05773911 Recruiting N/A Treatment of Advanced Periodontitis With a Chitosan Brush and a Chitosan Gel March 23, 2023 December 31, 2024
NCT05786820 Recruiting N/A Impact of Pycnogenol® on Gingival Inflammation March 17, 2022 March 1, 2024
NCT05816512 Recruiting N/A Antimicrobial Efficacy of Biogenic Gold Nano Particle From Pelargonium Graveolens Leaves Extract Mouthwash for Children April 1, 2023 March 20, 2024
NCT06411522 Recruiting N/A Clinical and Microbiological Comparison of 0.2% CHX and 0.05% CHX+0.05%CPC Mouthwashes in TPS Patients May 20, 2024 February 2025
NCT06413836 Recruiting N/A Evaluation of Photodynamic Therapy in Pieces With Presence of Fistula. May 1, 2024 January 2026
NCT05864989 Recruiting N/A Non-Incised Papilla Flap in Deep Supraossous Defects April 1, 2023 November 1, 2024
NCT04831060 Recruiting Periodontitis and Inflammation February 15, 2023 November 15, 2025
NCT05874882 Recruiting Early Phase 1 Evaluating the Efficacy of Resveratrol Containing Mouthwash as Adjunct Treatment Periodontitis: December 12, 2022 December 2023
NCT05887128 Recruiting Accuracy of Extra-oral Bite-wing Radiography in Detecting Calculus and Crestal Bone Loss June 1, 2023 June 1, 2025
NCT05892315 Recruiting N/A Timing of Re-evaluation After Steps I-II of Periodontal Therapy May 11, 2023 December 11, 2024
NCT06426550 Recruiting N/A Clinical and Microbiological Evaluation of Laser Therapy in the Treatment of Periodontal Disease in Stages III and IV May 6, 2024 March 2026
NCT05907161 Recruiting N/A Low Laser Therapy and Hyaluronic Acid as an Adjunct to Non-surgical Periodontal Therapy June 9, 2023 June 2025
NCT06428149 Recruiting N/A Three Types of Papilla Incision in Periodontal Surgery June 1, 2023 December 1, 2024
NCT05924373 Recruiting Phase 2 Human Dental Pulp Mesenchymal Stem Cells for the Treatment of Chronic Periodontitis Patients November 27, 2023 September 30, 2026
NCT06261515 Recruiting N/A Multi-omics Analysis of Oral-gut Microbial Profiles February 15, 2024 February 15, 2026
NCT05061511 Recruiting Expression of Inflammasomes in Peri-implantitis and Periodontitis May 1, 2021 December 2023
NCT05077618 Recruiting Nalysis of the Periodontal Microbiota in Elderly Subjects With and Without Alzheimer's Disease: a Case Control Study January 30, 2023 July 31, 2024
NCT05078411 Recruiting N/A Efficacy of Periodontal Risk Communication in Patients With and Without History of Tooth Loss December 1, 2021 December 31, 2022
NCT05088746 Recruiting Comparing Different Timings for Periodontal Re-evaluation After Non-surgical Periodontal Therapy (NSPT) June 1, 2021 September 2023
NCT05089214 Recruiting N/A ONE-1 Oral graNd Est 1 June 16, 2022 February 2023
NCT05945082 Recruiting N/A Fusobacterium Nucleatum at Colorectal Cancer Sites November 29, 2017 December 31, 2025
NCT05107622 Recruiting Phase 1/Phase 2 Administration of L. Paracasei 28.4 as an Adjunct to the Treatment of Periodontitis August 16, 2021 April 2024
NCT05948722 Recruiting N/A Behavioral Intervention Program Based on Motivational Interview May 2, 2023 September 1, 2024
NCT05950009 Recruiting Relationship Between Major Depression and Periodontal Diseases February 20, 2024 March 2026
NCT06286501 Recruiting N/A Targeting of Preventive Treatment for Adolescents at Risk of Oral Diseases April 18, 2024 December 31, 2025
NCT05119283 Recruiting N/A Clinical Study of a Formulation Containing Phtalox® in Periodontal Disease March 7, 2022 April 30, 2025
NCT05962801 Recruiting N/A Use of Dual-light Photodynamic Therapy as an Adjunct to Periodontal Treatment in Smokers January 23, 2023 September 1, 2024
NCT05964699 Recruiting N/A The Use of a Non-Incised Minimally Invasive Flap Procedure in Conjunction With Emdogain® MI Compared to Traditional SRCP July 31, 2023 July 31, 2024
NCT05971706 Recruiting N/A Ozone Application in Periodontal Treatment September 27, 2023 November 15, 2025
NCT05994885 Recruiting N/A Evaluation of Prognostic Potentials of Gingival Crevicular Fluid E-cadherin and Total Antioxidant Capacity February 15, 2023 December 25, 2023
NCT05995431 Recruiting N/A Impact of Bruxism in the Outcome of Subgingival Instrumentation for the Management of Stage 2 and Stage 3 Periodontitis. September 1, 2023 November 1, 2024
NCT05188196 Recruiting N/A Efficacy of Collagen Sponge Versus Collagen Membrane on Ridge Preservation of Periodontally Compromised Teeth April 30, 2022 April 30, 2024
NCT06006429 Recruiting N/A Intraoral Scanners as Periodontal and Dental Pathologies Diagnosis Tools May 11, 2022 December 11, 2026
NCT05237401 Recruiting N/A Non-surgical vs. Surgical Therapy for Periodontal Furcations April 21, 2022 January 2027
NCT05278416 Recruiting N/A Regular Home Use of Dual-light Photodynamic Therapy in the Management of Chronic Periodontitis February 8, 2022 November 30, 2025
NCT06024447 Recruiting N/A Impact of Subgingival Instrumentation on Masticatory Performance and Psychological Distress September 15, 2023 October 15, 2024
NCT06305533 Recruiting N/A Efficacy of Photodynamic Therapy and LASER Disinfection in Periodontal Therapy for Treatment of Periodontitis March 1, 2024 October 2024
NCT06306677 Recruiting Accuracy of an AI-clinical Knowledge-based Hybrid System for Detecting Periodontitis in OPG Images March 12, 2024 December 31, 2024
NCT06036472 Recruiting N/A Impact of Periodontal Therapy on Mental Health Parameters March 14, 2024 January 2026
NCT05334407 Recruiting N/A Effect of Implant Treatment and/or Dietary Advice on the Nutrition of Edentulous Ageing Subjects April 18, 2022 December 31, 2024
NCT06047132 Recruiting PREDICTIVE ABILITY OF A PANEL OF BIOMARKERS IN SALIVA IN HEALTHY AND PERIODONTALLY AFFECTED SUBJECTS October 23, 2023 December 2024
NCT06048016 Recruiting N/A Effect Of Scaling and Root Planning on ALP in Saliva and GCF In Periodontitis Patients Compared With Healthy Individuals June 15, 2023 July 10, 2024
NCT05355740 Recruiting The Effect of Post-surgical Chlorhexidine Mouth Washing on the Sub-gingival Periodontal Microbiome A Pilot Study February 3, 2023 June 25, 2024
NCT03797807 Recruiting N/A Minimally-invasive Non-surgical and Surgical Periodontitis Treatment March 20, 2019 April 30, 2025
NCT06058923 Recruiting N/A MIST Versus M-MIST for the Treatment of Intrabony Defects August 10, 2023 June 10, 2025
NCT05422742 Recruiting N/A Influence of SRP With MM on the Composition and Functional Characteristics of Subgingival Microbiome Communities October 15, 2021 December 2024
NCT05425784 Recruiting N/A Home Use of Dual-light Photodynamic Therapy for Chronic Periodontitis January 19, 2023 February 28, 2025
NCT06073704 Recruiting N/A Effects of Adjunct Antimicrobial Photodynamic Therapy in Periodontal Treatment of Patients With Obesity October 9, 2023 December 23, 2024
NCT06074861 Recruiting N/A Fasting-mimicking Diet and Periodontitis (FMD) December 4, 2023 January 31, 2025
NCT03997552 Recruiting N/A NIPSA Versus Marginal Approach by Palatal Incision and MIST in Periodontal Regeneration September 6, 2019 December 1, 2024
NCT03997578 Recruiting N/A Non-incised Papillae Surgical Approach (NIPSA) and Connective Tissue Graft Plus Emdogain for Periodontal Defects September 3, 2019 May 2, 2025
NCT05449938 Recruiting N/A Periodontal Phenotype and Scaling and Root Planing September 1, 2021 August 2022
NCT05449964 Recruiting N/A Single Sitting SRP vs Supra-gingival Scaling Followed by Sub-gingival SRP After One Week August 1, 2021 November 2022
NCT05460988 Recruiting N/A "Re-instrumentation vs Flap Surgery" August 11, 2022 May 11, 2024
NCT06090851 Recruiting N/A Herbal Pralines - Oral Health September 15, 2023 June 30, 2024
NCT05482373 Recruiting N/A Adjuvant Treatment in Elderly Patients With Periodontitis Through the Administration of a Supplement Rich in Oleuropein From the Olive Leaf April 15, 2021 December 2024
NCT05506917 Recruiting N/A Perio Treatment & Cerebrovascular Function July 12, 2022 September 2023
NCT05511454 Recruiting N/A Comparison of Salivary and Crevicular Protein Concentrations of FIBA, PLMN, HEMO and ApoH in Healthy and Periodontitis Patients June 22, 2023 March 1, 2025
NCT05513599 Recruiting Self-detection and Professional Screening Strategies for Early Detection of Periodontal Disease August 1, 2023 April 1, 2024
NCT05518747 Recruiting N/A Effect of Probiotics as Supplement to Non-surgical Periodontal Treatment September 1, 2022 December 31, 2023
NCT06105112 Recruiting N/A Periodontal Regeneration With Hyaluronic Acid or Enamel Matrix Derivatives October 1, 2023 October 1, 2026
NCT05548361 Recruiting N/A The Use of Chlorhexidine and a Probiotic Lozenge in the Nonsurgical Therapy of Periodontitis April 1, 2022 December 1, 2023
NCT06105125 Recruiting N/A Autologous Micrografts From the Palatal Mucosa for Periodontal Regeneration November 2, 2023 November 2, 2025
NCT05560087 Recruiting Association of PeRiODontal Disease and gUt Microbiome With Coronary artEry Disease (PRODUCE Study) September 20, 2022 December 2024
NCT05565404 Recruiting N/A Effect of mHealth on Interdental Brushing in Type 2 Embrasures" November 1, 2022 June 30, 2024
NCT06351982 Recruiting N/A Treatment Of Shallow Periodontal Pockets 4-6mm Using AIRFLOW Prophylaxis Master Device With Erythritol vs Manual Scalers March 1, 2024 January 1, 2026
NCT06123000 Recruiting N/A Modified Widman Flap vs Fibre Retention Osseous Resective Surgery October 21, 2023 October 21, 2025
NCT05655923 Recruiting Phase 1/Phase 2 Clinical and Biochemical Assessment of Ozonated Olive Oil Mixed Bone Substitute in Treating Intra Bony Periodontal Defect July 1, 2022 February 2023
NCT06465095 Recruiting Evaluation of Inflammasome Gene Polymorphisms in Periodontitis Patients July 1, 2024 April 14, 2025
NCT06366295 Recruiting N/A Comparison of Subgingival Mechanotherapy With and Without the Use of a Perioscope: Clinical Trial June 1, 2023 November 2024
NCT05664087 Recruiting N/A Effect of Photodynamic Therapy on Soft Tissue Healing After Tooth Extraction at Sites of Periodontal Infection February 14, 2023 June 1, 2024
NCT06131021 Recruiting Phase 3 Shaping the Indications for Periodontal Adjunctive Antibiotics in Dental Practice April 25, 2024 May 26, 2026
NCT06133335 Recruiting N/A Cystic Fibrosis and Periodontal Diseases July 20, 2023 January 20, 2025
NCT06382753 Recruiting Impact of Periodontal Supportive Therapy in Patients With Gingivitis and Periodontitis April 20, 2024 June 30, 2024
NCT02710903 Terminated N/A IL29 and IL28B Variants Associated With Periodontal Disease Pathogenesis May 2016 March 28, 2018
NCT02716259 Terminated N/A Periodontal and Cardiovascular Diseases Project February 19, 2016 February 20, 2020
NCT02441920 Terminated Chronic Periodontitis and Tooth Loss in Patients With Rheumatoid Arthritis November 2010 November 2012
NCT01806974 Terminated Phase 4 Consequences of Anti-interleukin 6 Immunotherapy Treatment for Rheumatoid Arthritis on Periodontium December 2012 June 2015
NCT01030666 Terminated Phase 4 Effect of Postsurgical Systemic Doxycycline After Regenerative Periodontal Therapy April 2007 February 2011
NCT04692246 Terminated N/A Effect of Essential Oils as Adjutants on the Treatment of Subjects With Periodontitis: Assessment of Metabolic Variables as Effect Modifiers November 1, 2019 March 1, 2020
NCT00906776 Terminated N/A Emdogain and Straumann Bone Ceramic in Infrabony Defects April 2007 July 2012
NCT02671136 Terminated N/A Hyperbaric Oxygen Therapy as Adjunctive Therapy to Scaling and Root-planing in the Management of Periodontitis in Patients With Type 2 Diabetes August 18, 2016 March 31, 2017
NCT01878864 Terminated Phase 2 Effect of Local Anesthesia in Patients With Marginal Periodontitis Undergoing Scaling and Root Planning November 2012 June 2013
NCT03755362 Terminated N/A Dental Carotid Cognitive Study April 8, 2019 February 25, 2021
NCT02315222 Unknown status Phase 2/Phase 3 Dietary Supplements and Periodontal Wound Healing November 2014
NCT01742728 Unknown status Nagasaki and Tokushima May 2009 March 2015
NCT05322369 Unknown status Prevalence of Periodontitis in Diabetic Patients of Egyptian Population May 2022 March 30, 2023
NCT04262011 Unknown status N/A Effect of Non-surgical Periodontal Treatment and C-reactive Protein Levels in Hemodialysis Patients February 29, 2020 June 1, 2021
NCT04270006 Unknown status Early Phase 1 Evaluation of Adipose Derived Stem Cells Exo.in Treatment of Periodontitis February 12, 2020 October 2021
NCT04279691 Unknown status Prolactin Hormone in Rheumatoid Arthritis Patients With Periodontitis March 2020 April 2020
NCT01405365 Unknown status N/A The Impact of Obesity on Nonsurgical Periodontal Therapy August 2009 December 2012
NCT00918060 Unknown status Phase 2 Clinical Effects of Locally-delivered Gel Containing Camella Sinensis Extracts as an Adjunct in Peridontitis Treatment February 2008 December 2010
NCT05372965 Unknown status N/A The Effects of Smoking on miRNA-223 Before-After Non-Surgical Periodontal Therapy in Patients With Stage-3, Grade-B Periodontitis May 5, 2022 June 1, 2023
NCT03733379 Unknown status Phase 3 Systemic Probiotics in the Periodontal Treatment November 5, 2018 December 30, 2021
NCT01358630 Unknown status Vascular and Periodontal Disease - Microbial, Genetic and Histological Causalities October 2008 October 2015
NCT03757260 Unknown status N/A Efficacy of Adjunctive Antimicrobial Photodynamic Therapy for Residual Pockets in Previously Surgically Treated Teeth January 8, 2019 August 2020
NCT00297531 Unknown status Phase 4 Study of Scaling and Root Planing With PerioWave Versus Scaling and Root Planing Alone in Chronic Periodontitis April 2006 October 2007
NCT05403164 Unknown status Epithelial Mesenchymal Transition and Periodontitis July 12, 2021 August 30, 2022
NCT03790605 Unknown status Phase 3 A Clinical Trial to Study the Effect of a Drug, Curcumin in Patients With Periodontitis September 4, 2019 December 1, 2020
NCT03791957 Unknown status The Association of Blood Haemoglobin and Colour of Gums December 20, 2019 January 2020
NCT03792113 Unknown status Phase 2/Phase 3 AUTOLOGOUS FIBRIN GLUE VERSES 4-0 SILK SUTURES IN PERIODONTAL FLAP CLOSURE May 2019 December 2020
NCT04628845 Unknown status N/A Endo-perio Lesion's Treatment With Using Diode Laser 940nm August 31, 2019 August 31, 2022
NCT03804086 Unknown status N/A Evaluation of Advanced PRF Combined With Nano-crystalline Hydroxyapatite for Management of Grade II Furcation Defects February 2019 February 2020
NCT01852240 Unknown status Periodontal Disease as a Risk Indicator for Erectile Dysfunction - A Cross-sectional Study on 100 Patients May 2013
NCT03841656 Unknown status Influence of Gum Disease Treatment on Long-term Dental Implant Success March 1, 2019 March 1, 2022
NCT03862456 Unknown status N/A Metronidazole vs Azithromycin in Periodontal Surgery for Patients Positive to Porphyromonas Gingivalis January 2013 July 2019
NCT00531154 Unknown status Evaluation of the Dental Health Condition in Obesity Patients Before and After Bariatric Surgery
NCT02091258 Unknown status Tooth Loss in Periodontitis Patients June 2014 December 2020
NCT03901911 Unknown status Prevalence of Periodontitis on a Sample of Adult Egyptian Population April 1, 2019 April 1, 2020
NCT05435378 Unknown status Early Phase 1 Effect of Adjunctive Use of Vitamin B3 and B9 on Myeloperoxidase Level in the GCF of Patients With Stage I and II Periodontitis July 1, 2022 December 1, 2022
NCT05441397 Unknown status Prevalence of Periodontitis Based Upon Principles Presented by the 2017 Classification: A Hospital-based Cross-sectional Study on a Sample of Young Egyptian Dental Patients June 30, 2022 August 30, 2023
NCT02267239 Unknown status Phase 4 Methodology Antiseptic Application, Influence on Oral Biofilm. October 2014
NCT04722094 Unknown status Prevalence of Periodontitis in Patients With Plaque Psoriasis. A Cross-sectional Study January 25, 2021 August 25, 2021
NCT04719026 Unknown status PERIODONTAL HEALTH IN PATIENTS ACUTELY ADMITTED FOR MYOCARDIAL INFARCTION: A CASE CONTROL STUDY February 16, 2018 December 31, 2022
NCT01379950 Unknown status Role of Macrophage in Inflammation Resolution in Periodontal Patients August 2011 August 2012
NCT04647123 Unknown status Evaluation of Biomarker Levels in Blood, Saliva and Gingival Fluid in Periodontitis January 1, 2020 March 1, 2021
NCT00296881 Unknown status Phase 4 SRP in Combination With PERIOWAVE in Comparison to SRP Alone in Chronic Periodontitis April 2006 December 2007
NCT04374383 Unknown status Phase 2 Novel Photosensitizer in The Treatment of Chronic Periodontitis June 1, 2019 November 2021
NCT04018144 Unknown status Running Title: PPAR-γ, RXR-α, and VDR Expressions in Periodontitis August 1, 2019 March 1, 2020
NCT04375618 Unknown status Phase 1 RhEGF Incorporated in An Absorbable Collagen Membrane for The Management Of Gingival Recession Defects October 1, 2019 November 2021
NCT04930588 Unknown status Levels of Neuregulin-4 and Its Receptor ErbB4 in Periodontitis Patients With and Without Diabetes Type 2 June 1, 2021 December 2023
NCT04956211 Unknown status N/A Periodontal Treatment and Ischemic Stroke September 29, 2021 December 29, 2023
NCT02633462 Unknown status Phase 2 Non-surgical Periodontal Therapy and Myo-inositol in Polycystic Ovary Syndrome Women Having Chronic Periodontitis May 2015 October 2016
NCT01750801 Unknown status Phase 3 Efficacy of a Mouthwash Containing Propolis February 2013 July 2016
NCT04908098 Unknown status N/A Diode Laser Application With Non-Surgical Periodontal Treatment November 10, 2019 August 10, 2021
NCT04027179 Unknown status Phase 4 Tongue Dysbiosis Effects on Arterial Pressure of Periodontitis Patients August 2020 July 2022
NCT04375839 Unknown status N/A Zirconia Vs Titanium Implants in Deficient Ridges March 6, 2020 November 2021
NCT04869904 Unknown status Oral Bacterial and Viral Mapping by Dental Plaque in Elderly Patients With and Without Alzheimer's Disease(ORal MICrobiology in Alzheimer's Patients) June 1, 2021 December 31, 2021
NCT01676545 Unknown status Genetics of Periodontal Diseases in Chinese July 2011
NCT00502606 Unknown status a Clinical Study.the Effect of Addition of Insoluble Antibacterial Nanoparticles(IABN) in Resin Base Provisional Cement February 2007 December 2011
NCT05021861 Unknown status Evaluation of Periodontal Status and hsCRP Levels in Females With PCOS on CPA/EE Combination Drug Regimen November 2021 September 30, 2022
NCT05029089 Unknown status N/A Modified Entire Papilla Preservation Technique For Treatment Of Intrabony Defects. Clinical Trial. September 10, 2021 September 1, 2023
NCT04046172 Unknown status N/A Treatment of Periodontal Disease in Systemic Lupus Erythematosus November 1, 2021 June 1, 2023
NCT04381585 Unknown status N/A Mini Distractor in Vertically Deficient Bone May 1, 2019 November 2021
NCT04381598 Unknown status Phase 2 Stevia Rebaudiana Bertoni on Levels of GCF Glucose and Bio-markers in Diabetics. April 1, 2019 November 2021
NCT04862819 Unknown status Phase 2 Evaluation of a New Local Drug Delivery in the Nonsurgical Treatment of Periodontitis January 2, 2021 December 30, 2021
NCT02874963 Unknown status N/A FM-SRP and Tooth Extraction Improve Type 2 Diabetes Mellitus in Periodontitis November 2015 October 2016
NCT04069611 Unknown status N/A Non Surgical Therapy of Periodontitis in Diabetes Patients: the Adjunctive Use of Probiotics January 30, 2020 December 31, 2023
NCT04850768 Unknown status (NOD)-Like Receptors CARD Domain-Containing 4 Levels in Individuals With Periodontitis April 16, 2021 September 20, 2021
NCT04634734 Unknown status Correlation Between Periodontitis and Hypertension Among a Sample of Adult Egyptian Patients December 1, 2020 October 1, 2021
NCT02931032 Unknown status N/A Diagnosis of Common Oral Diseases by Signature Volatile Profiles November 2016 November 2017
NCT02946801 Unknown status Phase 4 Antiplaque Effect of Essential Oils With and Without Alcochol on an in Situ Model of Oral Biofilm Growth November 2016 December 2016
NCT04125706 Unknown status N/A Locally Delivered Antibiotics for the Treatment of Periodontitis November 1, 2019 September 1, 2020
NCT05096897 Unknown status Oral Health-related Quality of Life (OHRQoL) in Patients With Inflammatory Bowel Disease (IBD) November 2022 November 2023
NCT04847830 Unknown status N/A Adjunctive Laser for Periodontal Intrabony Defects April 2021 June 2023
NCT02461823 Unknown status N/A The Influence of Porcelain Fused to Metal ( PFM) and Zirconia Crowns on Periodontal Health June 2015 August 2016
NCT04129684 Unknown status N/A A Clinical Trial to Evaluate the Effectiveness of Lactobacillus Reuteri for Periodontitis in a Chinese Population December 1, 2019 November 30, 2021
NCT02135952 Unknown status Phase 4 Metronidazole and Amoxicillin for the Treatment of Type 2 Diabetic Subjects With Periodontitis September 2011 October 2014
NCT02131922 Unknown status N/A Study of the Effects of Intensive Treatment of Periodontitis on Blood Pressure Control September 2009 September 2014
NCT03087240 Unknown status N/A Dental Prophylaxis and Rheumatoid Arthritis February 28, 2017 February 2020
NCT04771949 Unknown status Prevalence and Environmental Risk Indicators for Periodontitis. A Cross-sectional Study February 20, 2021 November 29, 2021
NCT01503593 Unknown status Phase 3 Using Combination of Synthetic Bone Substitutes During Extractions May 2012 May 2013
NCT02357745 Unknown status Evaluation of Neopterin Levels in Pre and Post-menopausal Women With Periodontitis Following Non Surgical Therapy February 2015 May 2015
NCT03506165 Unknown status N/A Relationship of Periodontitis and Cardiovascular Risk in Patients With Rheumatoid Arthritis April 1, 2019 September 2021
NCT04259034 Unknown status Periodontal Status in Oral Lichen Planus Patients January 1, 2020 April 30, 2021
NCT01691638 Unknown status Genetics of Periodontal Diseases in European Caucasians
NCT04399135 Unknown status N/A Accuracy of Pulp Sensibility Test on Teeth With Deep Periodontal Pocket February 25, 2020 June 20, 2022
NCT03588507 Unknown status N/A Clinical and Radiographic Evaluation of PPF With or Without NCHA Bone in Treatment of Intrabony Defects September 1, 2018 November 1, 2019
NCT05311501 Unknown status N/A Impact of Non-surgical Periodontal Therapy in the Management of Plaque Psoriasis. May 10, 2022 January 1, 2023
NCT05311657 Unknown status Oral Health and Severe COPD September 21, 2020 May 31, 2022
NCT04251650 Unknown status PAROMIP Pilot Study PAROdontites & MIcrobiota Periodontal May 1, 2019 March 31, 2020
NCT03381469 Unknown status N/A Periodontitis and Adverse Pregnancy Outcomes in Metabolic Syndrome Patients- Interventional Study February 10, 2018 December 1, 2018
NCT01598155 Unknown status N/A Effect of Supragingival Control Versus Supra- and Subgingival Control in the Periodontal Health During the Maintenance May 2012 January 2016
NCT04769622 Unknown status Influence of Environmental Factors on the Efficacy of Non-surgical Periodontal Treatment. A Pre-post Quasi-experimental Study February 16, 2021 November 25, 2021
NCT03098498 Unknown status N/A Impact of Debridement Invasiveness on Attachment Gain After Antiinfective Periodontal Therapy June 1, 2016 December 1, 2017
NCT04169945 Unknown status N/A Compare Air Polishing With Ultrasonic During Maintenance January 31, 2020 June 2021
NCT04172870 Unknown status Evaluation of Inflammatory Markers and Periodontal Viruses on Periodontitis Patients With CAD November 15, 2018 December 1, 2020
NCT04178291 Unknown status N/A Air Polishing as an Adjunct in Non-surgical Periodontal Therapy January 31, 2020 June 2021
NCT04668911 Unknown status Oral Health, Microbial Burden and COVID-19 December 13, 2020 December 12, 2021
NCT03137979 Unknown status Phase 1/Phase 2 Gingiva Mesenchymal Stem Cells Treatment of Chronic Periodontitis January 2017 December 2019
NCT05129267 Unknown status N/A Evaluation of iPRF With Vitamin C in StageII Grade A Periodontitis October 3, 2021 June 2, 2022
NCT03146390 Unknown status Phase 4 Essential Oils With and Without Alcohol: Substantivity and Antiplaque Effect May 2, 2017 August 31, 2017
NCT04446533 Unknown status Phase 3 Effect of a Hydrogen-Peroxide and Hyaluronic-Acid Mouthwash (BMG0703) in the Treatment of Periodontitis June 2020 July 2020
NCT03168217 Unknown status Classification of Periodontitis Revisited: A Cluster Analysis January 2003 June 2017
NCT04223076 Unknown status Phase 4 Clinical Effect of Chlorhexidine Mouthwash After Periodontal Surgery March 20, 2019 December 30, 2020
NCT04230096 Unknown status N/A Effects Of Low Level Laser Therapy On Tooth Movement,Treatment Related Complications Of Gingivitis,Periodontitis And Pain In Fixed Orthodontic Patients July 1, 2021 December 31, 2021
NCT03218228 Unknown status N/A Immediate Implant Placement in Aggressive Periodontitis June 10, 2017 December 8, 2018
NCT02417363 Unknown status Study on the Relationship Between Periodontitis and Renal Disease October 2013 October 2016
NCT04236648 Unknown status N/A Minimally-invasive Non-surgical Treatment in Teeth With Unfavourable Prognosis February 1, 2020 October 31, 2023
NCT03269799 Unknown status Phase 2 Vitamin C as an Adjunct in Periodontal Treatment in Type 2 Diabetes Mellitus Patients August 30, 2017 August 19, 2018
NCT05189132 Unknown status Periodonitis and Alzheimer's Disease September 1, 2022 January 2023
NCT00969241 Unknown status The Effect of Periodontal Treatment on the Level of Free Radicals in the Saliva July 2009
NCT05205694 Unknown status Oral Health in Covid-19 Survivors September 20, 2021 June 30, 2023
NCT01641757 Unknown status Phase 2 Effect of Non-Surgical Periodontal Therapy on Serum Albumin Levels of Patients on Maintenance Hemodialysis Therapy, May 2012 October 2012
NCT05232331 Unknown status N/A Intake of Vegetables Rich in Nitrate and Its Effect on the Oral Microbiota of Patients With Periodontitis June 23, 2021 November 30, 2022
NCT04670133 Withdrawn N/A Inulin Supplementation During Sanative Therapy to Further Improve Periodontal Healing January 1, 2024 December 31, 2026
NCT05669560 Withdrawn Early Phase 1 Efficacy of Hydrogen Peroxide Gel on Periodontitis With Diabetes January 20, 2023 June 30, 2027
NCT03176537 Withdrawn Phase 4 Periodontal Profile of Hypogonadic Men May 1, 2017 December 31, 2020
NCT02520375 Withdrawn N/A Effects of Prebiotic Oral Healthcare Products as an Adjunct to Non-surgical Periodontal Therapy
Disase is a (Disease Ontology)
DOID:3388
Cross Reference ID (Disease Ontology)
EFO:0000649
Cross Reference ID (Disease Ontology)
ICD10CM:K05.3
Cross Reference ID (Disease Ontology)
MESH:D010518
Cross Reference ID (Disease Ontology)
NCI:C34918
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:266491004
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0031099
Exact Synonym (Disease Ontology)
chronic pericementitis
HPO alt_id (Human Phenotype Ontology)
HP:0000165
HPO alt_id (Human Phenotype Ontology)
HP:0006301
HPO Human Phenotype ID (Human Phenotype Ontology)
HP:0000704
MeSH unique ID (MeSH (Medical Subject Headings))
D010518