Waldenstrom Macroglobulinemia

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Information
Disease name
Waldenstrom Macroglobulinemia
Disease ID
Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT04450069 Active, not recruiting Phase 1 CLBR001 and SWI019 in Patients With Relapsed / Refractory B-cell Malignancies August 14, 2020 June 2024
NCT05024045 Active, not recruiting Phase 1 Study of Oral LOXO-338 in Patients With Advanced Blood Cancers September 30, 2021 December 2024
NCT03506373 Active, not recruiting Phase 2 Ibrutinib and Ixazomib Citrate in Treating Newly Diagnosed, Relapsed or Refractory Waldenstrom Macroglobulinemia July 5, 2018 May 1, 2025
NCT04273139 Active, not recruiting Phase 2 Ibrutinib + Venetoclax in Untreated WM July 9, 2020 February 1, 2028
NCT01479842 Active, not recruiting Phase 1 Rituxan/Bendamustine/PCI-32765 in Relapsed DLBCL, MCL, or Indolent Non-Hodgkin's Lymphoma December 7, 2011 December 31, 2024
NCT03521596 Active, not recruiting Non-invasive Diagnostics and Monitoring of MRD and Clonal Evolution in Waldenström's Macroglobulinemia and in IgM-MGUS August 28, 2018 October 2025
NCT02339922 Active, not recruiting Phase 2 Ixazomib Citrate and Rituximab in Treating Patients With Indolent B-cell Non-Hodgkin Lymphoma May 19, 2016 January 6, 2031
NCT03620903 Active, not recruiting Phase 2 Efficacy of First Line B-RI for Treatment Naive Waldenström's Macroglobulinemia September 11, 2019 September 2029
NCT04464200 Active, not recruiting Phase 1 19(T2)28z1xx Chimeric Antigen Receptor (CAR) T Cells in People With B-Cell Cancers July 6, 2020 July 2026
NCT00039676 Active, not recruiting Clinical, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Hematologic Cancer July 8, 2002
NCT04018248 Active, not recruiting Phase 1 BR101801 in Adult Patients With Advanced Hematologic Malignancies( Phase I) April 21, 2020 March 2024
NCT03333486 Active, not recruiting Phase 2 Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer December 7, 2017 August 28, 2024
NCT03740529 Active, not recruiting Phase 1/Phase 2 A Study of Oral LOXO-305 in Patients With Previously Treated CLL/SLL or NHL November 16, 2018 January 2028
NCT03133221 Active, not recruiting Phase 2 1630GCC: Zydelig Maintenance in B-Cell Non-Hodgkin's Lymphoma After Autologous Stem Cell Transplantation October 23, 2017 March 2025
NCT03162536 Active, not recruiting Phase 1/Phase 2 A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001) June 26, 2017 September 12, 2025
NCT03192397 Active, not recruiting Phase 1/Phase 2 Chemotherapy, Total Body Irradiation, and Post-Transplant Cyclophosphamide in Reducing Rates of Graft Versus Host Disease in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant August 9, 2017 May 21, 2027
NCT05172700 Available Expanded Access Program for Pirtobrutinib for Participants With B-Cell Cancer
NCT01075321 Completed Phase 1/Phase 2 Everolimus and Lenalidomide in Treating Patients With Relapsed or Refractory Non-Hodgkin or Hodgkin Lymphoma January 10, 2011 February 13, 2020
NCT01076543 Completed Phase 1/Phase 2 Lenalidomide and Temsirolimus in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma April 15, 2010 September 30, 2018
NCT01093586 Completed Phase 2 Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies September 2007 December 2015
NCT01109069 Completed Phase 2 Safety and Tolerability Study of PCI-32765 in B Cell Lymphoma and Chronic Lymphocytic Leukemia June 2010 April 26, 2019
NCT01118689 Completed Phase 1 Dose Escalation Study of MLN0128 in Relapsed or Refractory Multiple Myeloma or Waldenstrom Macroglobulinemia November 2010 July 2013
NCT01129193 Completed Phase 1 AR-42 in Treating Patients With Advanced or Relapsed Multiple Myeloma, Chronic Lymphocytic Leukemia, or Lymphoma May 4, 2010 January 7, 2017
NCT01177371 Completed Phase 2 High-Dose Busulfan and High-Dose Cyclophosphamide Followed By Donor Bone Marrow Transplant in Treating Patients With Leukemia, Myelodysplastic Syndrome, Multiple Myeloma, or Recurrent Hodgkin or Non-Hodgkin Lymphoma March 1988 February 2010
NCT01199562 Completed Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant December 2010 December 2013
NCT01231412 Completed Phase 3 Graft-Versus-Host Disease Prophylaxis in Treating Patients With Hematologic Malignancies Undergoing Unrelated Donor Peripheral Blood Stem Cell Transplant November 2010 June 30, 2017
NCT01251575 Completed Phase 2 Sirolimus, Cyclosporine, and Mycophenolate Mofetil in Preventing Graft-versus-Host Disease in Treating Patients With Blood Cancer Undergoing Donor Peripheral Blood Stem Cell Transplant December 1, 2010 February 11, 2019
NCT01254578 Completed Phase 1 Lenalidomide After Donor Bone Marrow Transplant in Treating Patients With High-Risk Hematologic Cancers November 24, 2010 November 9, 2012
NCT01261247 Completed Phase 2 Panobinostat in Treating Patients With Relapsed or Refractory Non-Hodgkin Lymphoma January 17, 2011 December 2, 2019
NCT01272817 Completed N/A Nonmyeloablative Allogeneic Transplant October 2001 October 2015
NCT01273766 Completed Phase 2 Deferasirox in Treating Iron Overload Caused By Blood Transfusions in Patients With Hematologic Malignancies January 2011 December 2014
NCT01326702 Completed Phase 1/Phase 2 Veliparib, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory Lymphoma, Multiple Myeloma, or Solid Tumors July 2011 April 2015
NCT01351935 Completed Phase 1 Escalating Dose Study in Subjects With Relapsed or Refractory B Cell Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, and Waldenstrom's Macroglobulinemia July 18, 2011 June 26, 2015
NCT01523223 Completed Phase 1 Donor Peripheral Stem Cell Transplant in Treating Patients With Hematolymphoid Malignancies January 2012 October 2016
NCT01527045 Completed Phase 2 Donor Atorvastatin Treatment in Preventing Severe Acute GVHD After Nonmyeloablative Peripheral Blood Stem Cell Transplant in Patients With Hematological Malignancies September 25, 2012 April 2019
NCT03833180 Completed Phase 1 A Study of Zilovertamab Vedotin (MK-2140) (VLS-101) in Participants With Hematologic Malignancies (MK-2140-001) March 14, 2019 December 18, 2023
NCT01567709 Completed Phase 1 Alisertib in Combination With Vorinostat in Treating Patients With Relapsed or Recurrent Hodgkin Lymphoma, B-Cell Non-Hodgkin Lymphoma, or Peripheral T-Cell Lymphoma April 16, 2012 March 29, 2018
NCT01813227 Completed Phase 2 A Phase II Study of Carfilzomib in Relapsed Waldenström's Macroglobulinemia (WM) IST-CAR-531 April 2013 October 2018
NCT02257242 Completed Phase 1 Vincristine Sulfate Liposome Injection (Marqibo®), Bendamustine and Rituximab-Phase I Trial in Indolent B-cell Lymphoma May 10, 2017 November 18, 2020
NCT00072514 Completed Phase 2 Gemcitabine Hydrochloride, Carboplatin, Dexamethasone, and Rituximab in Treating Patients With Previously Treated Lymphoid Malignancies August 2003 November 2013
NCT02302469 Completed Phase 1/Phase 2 Study of Lenalidomide in Relapse/Refractory Waldenstrom Macroglobulinemia March 2009 April 2017
NCT02332980 Completed Phase 2 Pembrolizumab Alone or With Idelalisib or Ibrutinib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Other Low-Grade B-Cell Non-Hodgkin Lymphomas February 19, 2015 January 4, 2022
NCT02669017 Completed Phase 1 Study of ADCT-402 in Patients With Relapsed or Refractory B-cell Lineage Non Hodgkin Lymphoma (B-NHL) March 2016 February 21, 2019
NCT02677324 Completed Phase 2 Study of ABT-199 (GDC-199) In Patients With Relapsed Or Refractory Waldenström Macroglobulinemia May 9, 2016 February 7, 2022
NCT02916979 Completed Phase 1 Myeloid-Derived Suppressor Cells and Checkpoint Immune Regulators' Expression in Allogeneic SCT Using FluBuATG September 6, 2016 February 11, 2022
NCT00075478 Completed Phase 3 Total-Body Irradiation With or Without Fludarabine Phosphate Followed By Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer October 2003 February 2, 2014
NCT02962401 Completed Phase 2 Efficacity of Idelalisib and Obinutuzumab in Patient With Relapsed Refractory Waldenstrom's Macroglobulinemia March 7, 2017 April 13, 2023
NCT04062448 Completed Phase 2 A Study of Ibrutinib in Combination With Rituximab, in Japanese Participants With Waldenstrom's Macroglobulinemia (WM) September 25, 2019 March 2, 2023
NCT04042376 Completed Phase 4 A Study of Ibrutinib (PCI-32765) in Chinese Participants With Relapse or Refractory Waldenstrom's Macroglobulinemia (WM) December 18, 2019 March 19, 2024
NCT01529827 Completed Phase 2 Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies February 28, 2012 August 29, 2019
NCT03630042 Completed Phase 2 Investigating the Safety and Efficacy of Rituximab and Pembrolizumab in Relapsed/Refractory Waldenström's Macroglobulinaemia September 6, 2019 June 1, 2023
NCT00082784 Completed Phase 1 Bortezomib and Flavopiridol in Treating Patients With Recurrent or Refractory Indolent B-Cell Neoplasms March 2004 September 2014
NCT00083707 Completed Phase 2 Anti-Angiogenesis Therapy Using Thalidomide in Patients With Waldenstrom's Macroglobulinemia January 1999 February 2003
NCT00096161 Completed Phase 2 Pentostatin and Lymphocyte Infusion in Preventing Graft Rejection in Patients Who Have Undergone Donor Stem Cell Transplant May 2003 August 2015
NCT00105001 Completed Phase 2 Tacrolimus and Mycophenolate Mofetil With or Without Sirolimus in Preventing Acute Graft-Versus-Host Disease in Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer November 2004 May 8, 2015
NCT06084650 Completed Optical Coherence Tomography (OCT) and OCT Angiography(OCTA) Deep Learning in Waldenström's Macroglobulinemia Patients January 1, 2023 October 1, 2023
NCT00244855 Completed Phase 2 Rituximab and Dexamethasone in Treating Patients With Low-Grade Non-Hodgkin Lymphoma May 2004 August 29, 2011
NCT00438880 Completed Phase 1/Phase 2 Agatolimod Sodium, Rituximab, and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Recurrent or Refractory Non-Hodgkin Lymphoma October 2004 November 2014
NCT00608361 Completed Phase 1 Dasatinib in Treating Patients With Solid Tumors or Lymphomas That Are Metastatic or Cannot Be Removed By Surgery October 2008 August 2014
NCT00711828 Completed Phase 2 Rituximab, Cyclophosphamide, Bortezomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Low-Grade Follicular Lymphoma, Waldenstrom Macroglobulinemia, or Mantle Cell Lymphoma August 2008 April 6, 2018
NCT00720135 Completed Phase 1 Fusion Protein Cytokine Therapy After Rituximab in Treating Patients With B-Cell Non-Hodgkin Lymphoma January 2008 July 2014
NCT00777738 Completed Phase 2 Efficacy of Bortezomib (Velcade(R)) in Patients With Advanced Waldenström Macroglobulinemia October 2008 August 2012
NCT00783367 Completed Phase 2 Combination Therapy Using Lenalidomide (Revlimid)- Low Dose Dexamethasone and Rituximab for Treatment of Rituximab-Resistant, Non-Aggressive B-Cell Lymphomas July 2008 November 23, 2020
NCT00789776 Completed Phase 1/Phase 2 Fludarabine Phosphate, Cyclophosphamide, Total-Body Irradiation, and Donor Bone Marrow Transplant Followed by Donor Natural Killer Cell Therapy, Mycophenolate Mofetil, and Tacrolimus in Treating Patients With Hematologic Cancer October 13, 2008 May 2017
NCT00861510 Completed Phase 1 A Pilot Study of the Safety and Activity of Escalating Doses of ON 01910.Na in Patients With Relapsed Mantle Cell Lymphoma, Multiple Myeloma, Chronic Lymphocytic Leukemia, and Related Lymphoid Malignancies March 5, 2009 October 19, 2012
NCT01008462 Completed Phase 2 Autologous Peripheral Blood Stem Cell Transplant Followed by Donor Bone Marrow Transplant in Treating Patients With High-Risk Hodgkin Lymphoma, Non-Hodgkin Lymphoma, Multiple Myeloma, or Chronic Lymphocytic Leukemia March 18, 2010 June 30, 2018
NCT03364231 Completed Phase 2 Study to Assess the Efficacy and Safety of Umbralisib in Participants With Non-Follicular Indolent Non-Hodgkin's Lymphoma November 30, 2017 February 15, 2022
NCT04488354 Enrolling by invitation Phase 1 Long-term Follow-up Study for Patients Treated With CLBR001 CAR-T January 21, 2021 August 2036
NCT01804686 Enrolling by invitation Phase 3 A Long-term Extension Study of PCI-32765 (Ibrutinib) September 9, 2013 January 29, 2027
NCT05099471 Not yet recruiting Phase 2 Efficacy of Venetoclax in Combination With Rituximab in Waldenström's Macroglobulinemia September 2024 October 2032
NCT04702932 Not yet recruiting Establishment of Genomic, Transcriptomic and Functional Characteristics of Tumor Cells in Hyperinflammatory Hemopathies September 1, 2021 September 1, 2036
NCT06340737 Recruiting Phase 1 AutologousCD22 Chimeric Antigen Receptor (CAR)T Cells in w/Recurrent/Refractory B Cell Lymphomas March 29, 2024 April 2031
NCT00923507 Recruiting Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL) May 29, 2008
NCT02269592 Recruiting Study of MGUS, Smoldering Myeloma, Early MDS and CLL to Assess Molecular Events of Progression and Clinical Outcome August 2014 September 2030
NCT02952508 Recruiting Phase 2 Study of Iopofosine I 131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) and Pivotal Expansion in Waldenstrom Macroglobulinemia July 26, 2017 June 30, 2025
NCT03820817 Recruiting Phase 1 Rifaximin in Patients With Monoclonal Gammopathy May 15, 2019 November 30, 2025
NCT04028479 Recruiting The Registry of Oncology Outcomes Associated With Testing and Treatment May 5, 2021 October 1, 2031
NCT04061512 Recruiting Phase 2/Phase 3 Rituximab and Ibrutinib (RI) Versus Dexamethasone, Rituximab and Cyclophosphamide (DRC) as Initial Therapy for Waldenström's Macroglobulinaemia February 3, 2020 March 2030
NCT04072458 Recruiting Phase 1 A Clinical Trial of BP1002 in Patients With Advanced Lymphoid Malignancies November 5, 2020 January 2026
NCT04116437 Recruiting Phase 2 Zanubrutinib (BGB-3111) in Participants With Previously Treated B-Cell Lymphoma Intolerant of Prior Bruton Tyrosine Kinase Inhibitor (BTKi) Treatment October 15, 2019 October 2025
NCT04260217 Recruiting Phase 1 APG-2575 Single Agent or in Combination With Ibrutinib or Rituximab in Patients With Waldenström Macroglobulinemia May 30, 2021 December 30, 2025
NCT04263480 Recruiting Phase 2 Efficacy and Safety of Carfilzomib in Combination With Ibrutinib vs Ibrutinib in Waldenström's Macroglobulinemia February 18, 2021 February 2028
NCT04624906 Recruiting Phase 2 Bendamustine, Rituximab and Acalabrutinib in Waldenstrom's Macroglobulinemia March 2, 2021 March 2030
NCT04775745 Recruiting Phase 1 Study of Oral Administration of LP-168 in Patients With Relapsed or Refractory B-cell Malignancies. July 19, 2021 December 31, 2025
NCT04840602 Recruiting Phase 2 Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib and Rituximab) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphoma January 5, 2022 March 31, 2028
NCT04898647 Recruiting N/A Clinical Study of the Hyperviscosity Syndrome in Waldenström Macroglobulinemia May 14, 2021 August 2024
NCT05020678 Recruiting Phase 1 NKX019, Intravenous Allogeneic Chimeric Antigen Receptor Natural Killer Cells (CAR NK), in Adults With B-cell Cancers August 20, 2021 December 2038
NCT05065554 Recruiting Phase 2 ACALA-R In Predominantly Demyelinating IgM Mediated Neuropathy November 16, 2021 October 1, 2028
NCT05093153 Recruiting Spanish Registry of Patients With IgM Monoclonal Gammopathies October 1, 2021 March 31, 2025
NCT05190705 Recruiting Phase 2 Loncastuximab Tesirine in WM February 17, 2022 August 1, 2027
NCT05544019 Recruiting Phase 1 Study of SGR-1505 in Mature B-Cell Neoplasms April 10, 2023 March 2026
NCT05602363 Recruiting Phase 1 AS-1763 in Patients With Previously Treated CLL/SLL or Non-Hodgkin Lymphoma August 1, 2023 September 2027
NCT05640102 Recruiting Observational Study Evaluating the Efficacy and Safety of Zanubrutinib in Participants With Waldenström Macroglobulinemia March 3, 2023 December 2027
NCT05734495 Recruiting Phase 2 Pirtobrutinib and Venetoclax in Waldenström Macroglobulinemia May 2, 2023 January 25, 2033
NCT05914662 Recruiting Phase 2 Zanubrutinib Plus BR in Newly Diagnosed Symptomatic WM February 15, 2023 December 15, 2025
NCT05952037 Recruiting Phase 2 Study to Evaluate the Efficacy and Safety of BGB-11417 in Participants With Waldenström's Macroglobulinemia September 28, 2023 September 2028
NCT06151730 Recruiting Evaluation of Hypertension Management and Cardiovascular Adverse Event Prevention in Patients With B-cell Malignancies Undergoing Treatment With Bruton Tyrosine Kinase Inhibitors, the HALT Study January 5, 2024 December 1, 2025
NCT01416428 Terminated Phase 1/Phase 2 Open-label Study of the Safety and Activity of Oprozomib in Patients With Hematologic Malignancies October 15, 2011 August 12, 2019
NCT03679624 Terminated Phase 2 Daratumumab Plus Ibrutinib in Patients With Waldenstrӧm's Macroglobulinemia July 30, 2020 October 13, 2020
NCT01045928 Terminated Phase 1 Lenalidomide And Rituximab as Maintenance Therapy in Treating Patients With B-Cell Non-Hodgkin Lymphoma January 2010 March 2012
NCT03269552 Terminated Phase 2 Carfilzomib With or Without Rituximab in the Treatment of Waldenstrom Macroglobulinemia or Marginal Zone Lymphoma December 18, 2017 December 28, 2018
NCT03037645 Terminated Phase 1/Phase 2 Safety, PK, PD, and Antitumor Activity of Vecabrutinib (SNS-062) in B Lymphoid Cancers April 28, 2017 August 31, 2020
NCT00113802 Terminated Phase 2 Study of Epratuzumab (hLL2) in Patients With Waldenstrom's Macroglobulinemia August 2004 December 2006
NCT04115059 Terminated Phase 1 Dasatinib In Waldenström Macroglobulinemia November 4, 2019 December 31, 2021
NCT01116154 Terminated Phase 1 Vorinostat and Lenalidomide in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma May 2010 August 2010
NCT02109224 Terminated Phase 1 Ibrutinib in Treating Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma in Patients With HIV Infection September 2014 July 2015
NCT02086591 Terminated Phase 2 A Phase II Study of Doxycycline in Relapsed NHL March 2014 November 2015
NCT01779167 Terminated Phase 2 Thalidomide, Lenalidomide, and Rituximab for Previously Treated Waldenstrom Macroglobulinemia June 2012 April 2014
NCT00107614 Terminated Phase 2 DT PACE, Tandem Autologous Transplant, Maintenance Therapy for Waldenstrom's Macroglobulinemia Patients November 2002 February 2008
NCT03601819 Terminated Phase 1 Pacritinib in Relapsed/Refractory Lymphoproliferative Disorders May 15, 2019 July 17, 2020
NCT03335098 Unknown status Phase 2 Study of VTD in Waldenstrom's Macroglobulinemia November 21, 2016 December 2020
NCT05003141 Unknown status Phase 1 PSB202 in Patients With Previously Treated-, Relapsed-, Indolent B-Cell Malignancies November 15, 2021 January 2024
NCT04830046 Unknown status Covid-19 Vaccine Responsiveness in MM and Waldenstrom September 2021 August 1, 2022
NCT03679455 Unknown status Phase 2 A Study of Obinutuzumab (RO5072759) Induction in Patients With Relapsed/ Refractory Waldenström Macroglobulinemia, OBI-1 September 21, 2018 December 2022
NCT04893564 Withdrawn N/A Prognostic Value of Circulating Tumoral DNA After the First 6 Months of Treatment in Patients With Waldenström Macroglobulinemia May 14, 2021 May 2024
NCT00003512 Withdrawn Phase 2 Antineoplaston Therapy in Treating Patients With Recurrent or Refractory Waldenstrom's Macroglobulinemia February 18, 1999 April 26, 2000
NCT02298816 Withdrawn B-Cell Hematologic Malignancy Vaccination Registry August 2014 December 2025
NCT04665115 Withdrawn Phase 2 Ibrutinib for the Treatment of Patients With B-Cell Malignancies Who Are Infected With Coronavirus Disease 2019 (COVID-19) November 23, 2020 July 22, 2022
NCT05176691 Withdrawn Phase 1 HMPL-760 Safety and Tolerability Study in Patients With Previously Treated CLL/SLL or NHL February 15, 2022 November 16, 2022
NCT04043845 Withdrawn Phase 1 ERK 1/2 Signaling in Ibrutinib Resistant B-cell Malignancies February 3, 2020 February 3, 2020
MedGen concept unique identifier (MedGen Concept name)
C1835192
MedGen unique identifier (MedGen Concept name)
320546
MeSH unique ID (MeSH (Medical Subject Headings))
D008258