bipolar I disorder
Information
- Disease name
- bipolar I disorder
- Disease ID
- DOID:14042
- Description
- "A bipolar disorder that is characterized by at least one manic or mixed episode." [url:http\://en.wikipedia.org/wiki/Bipolar_I]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT03484494 | Active, not recruiting | N/A | Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar Depression | May 29, 2018 | August 30, 2023 |
| NCT05658510 | Active, not recruiting | Phase 3 | Dexmedetomidine in the Treatment of Agitation Associated With Schizophrenia and Bipolar Disorder (SERENITY III) | November 21, 2022 | March 30, 2025 |
| NCT05249309 | Active, not recruiting | Naturalistic Study of Ketamine in the Treatment of Depression | May 1, 2021 | December 15, 2023 | |
| NCT04209140 | Active, not recruiting | Optimizing Response to Li Treatment Through Personalized Evaluation of Individuals With Bipolar I Disorder: The R-LiNK Initiative | January 10, 2020 | June 2024 | |
| NCT03641300 | Active, not recruiting | N/A | Efficacy of Convulsive Therapies for Bipolar Depression | September 21, 2018 | August 30, 2024 |
| NCT03788811 | Active, not recruiting | ERG Components in Schizophrenia and Bipolar Disorder Type I | July 5, 2018 | December 31, 2024 | |
| NCT00177463 | Completed | N/A | L-Carnosine for Bipolar I Disorder | September 2004 | December 2007 |
| NCT00178061 | Completed | Phase 4 | Effects of Comorbid Personality Disorder on the Treatment of Bipolar I Disorder | August 1997 | August 2002 |
| NCT00195780 | Completed | Phase 3 | A Study for the Treatment of Mania Associated With Bipolar I Disorder in Children and Adolescents | February 2005 | |
| NCT00227305 | Completed | Phase 3 | Quetiapine Fumarate (SEROQUEL) in the Treatment of Adolescent Patients With Schizophrenia and Bipolar I Disorder | August 2004 | December 2007 |
| NCT00228059 | Completed | Phase 3 | An Open-label Extension Study to Evaluate the Safety and Tolerability of Licarbazepine in the Treatment of Manic Episodes of Bipolar I Disorder. | January 2005 | July 2007 |
| NCT00232414 | Completed | Phase 3 | A Double-Blind Randomized Placebo Controlled Study of Quetiapine for the Treatment of Depression in Adolescents With Bipolar Disorder | October 2005 | December 2007 |
| NCT00238485 | Completed | Phase 3 | An Open-label Extension Study to Evaluate the Safety and Tolerability of Licarbazepine 750-2000 mg/d in the Treatment of Manic Episodes of Bipolar I Disorder | January 2005 | July 2007 |
| NCT00350857 | Completed | Phase 4 | The Young Adult and Pediatric Bipolar Study | July 2006 | October 2007 |
| NCT00402324 | Completed | Phase 4 | A Comparison of Olanzapine in Combination With a Mood Stabilizer vs Mood Stabilizer Alone, in Mixed Bipolar Patients | December 2006 | February 2008 |
| NCT00606177 | Completed | Phase 3 | A Multicenter, Placebo-controlled, Double-blind Investigative Extension Trial of the Safety and Efficacy of Aripiprazole in the Treatment of Patients With Bipolar Disorder Experiencing a Manic or Mixed Episode | January 2008 | November 2010 |
| NCT00606229 | Completed | Phase 3 | A Multicenter Investigative Study of the Safety and Efficacy of Long-term Administration of Aripiprazole in Combination With Mood Stabilizer for the Treatment of Patients With Bipolar Disorder Experiencing a Manic or Mixed Episode | January 2008 | November 2010 |
| NCT00606281 | Completed | Phase 3 | A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group-comparison Trial of Aripiprazole in the Treatment of Patients With Bipolar Disorder Experiencing a Manic or Mixed Episode | January 2008 | November 2010 |
| NCT00606320 | Completed | Phase 3 | A Multicenter, Investigative Study of the Safety and Efficacy of Extended Administration of Aripiprazole in Combination With Mood Stabilizer for the Treatment of Patients With Bipolar Disorder Experiencing a Manic or Mixed Episode | January 2008 | November 2010 |
| NCT00618748 | Completed | Phase 3 | Safety and Efficacy of Olanzapine in the Long-term Treatment for Bipolar I Disorder, Depressed | February 2008 | September 2010 |
| NCT00709202 | Completed | Phase 2 | Efficacy and Tolerability Study of Betahistine to Ameliorate Antipsychotic Associated Weight Gain | July 2008 | December 2016 |
| NCT00721955 | Completed | Phase 3 | Staccato Loxapine in Agitated Patients With Bipolar Disorder | July 2008 | October 2008 |
| NCT00746343 | Completed | N/A | Reducing Medical Risks in Individuals With Bipolar Disorder - Full Study | September 2008 | September 2013 |
| NCT00761761 | Completed | Phase 3 | Sensoril(Ashwaganhda)for Bipolar Disorder | October 2008 | March 2011 |
| NCT00958633 | Completed | Phase 3 | Mood Stabilizer (MS)+ Antidepressant vs MS + Placebo in Maintenance of Bipolar Disorder. | November 2010 | May 20, 2020 |
| NCT00976794 | Completed | Phase 4 | Efficacy of Combined Treatment for Young Bipolar I Disorder | January 2009 | June 2012 |
| NCT00046384 | Completed | Phase 3 | Study of Aripiprazole in the Treatment of Patients With Acute Symptoms of Bipolar Disorder | June 2002 | April 2003 |
| NCT01058668 | Completed | Phase 3 | Safety and Efficacy of Cariprazine for Bipolar I Disorder | February 2010 | December 2011 |
| NCT01059539 | Completed | Phase 3 | Long-term Safety and Tolerability of Cariprazine for Bipolar I Disorder | February 28, 2010 | February 29, 2012 |
| NCT01075295 | Completed | N/A | Prevention of Weight Gain in Early Psychoses | February 2010 | December 2012 |
| NCT01206517 | Completed | Phase 1 | A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Sublingual Asenapine in a Pediatric Population With Schizophrenia or Bipolar I Disorder (P06522 AM1) | July 18, 2010 | August 4, 2011 |
| NCT01207505 | Completed | N/A | Emotion Regulation Group Therapy for Bipolar Disorder | July 2010 | December 2013 |
| NCT01358357 | Completed | Phase 3 | Bipolar Maintenance Study of Lurasidone Adjunctive to Lithium or Divalproex | June 2011 | April 2015 |
| NCT01395992 | Completed | Phase 3 | Long-Term Safety Extension Trial of Asenapine in Bipolar 1 Disorder Participants Who Completed Protocol P05691 (P05692) | April 2012 | January 2015 |
| NCT01567527 | Completed | Phase 3 | Efficacy, Safety, and Tolerability of an Intramuscular Formulation of Aripiprazole (OPC-14597) as Maintenance Treatment in Bipolar I Patients | August 2012 | April 2016 |
| NCT01570894 | Completed | N/A | Crossover Bioequivalence Study of Quetiapine Fumarate 25 mg Tablets Under Fed Conditions | July 2007 | July 2007 |
| NCT01570959 | Completed | N/A | Crossover Bioequivalence Study of Quetiapine Fumarate 300 mg Tablets Under Steady State Fasted Conditions | April 2007 | November 2007 |
| NCT01575561 | Completed | Phase 3 | This is an Open-label, Multi-center, Extension Study Designed to Evaluate the Longer Term Safety, Tolerability and Effectiveness of Lurasidone, Flexibly Dosed, Adjunctive to Lithium or Divalproex for the Treatment of Subjects With Bipolar I Disorder Who Have Participated in Study D1050296 | June 2012 | July 2015 |
| NCT01588457 | Completed | Phase 4 | Sequential Multiple Assignment Treatment for Bipolar Disorder | June 2011 | December 2016 |
| NCT01655030 | Completed | N/A | Creatine Monohydrate as Adjuvant Therapy for Bipolar Depression | July 2012 | March 2016 |
| NCT01731119 | Completed | Phase 2 | Study of Lurasidone in Treating Antipsychotic Naive or Quasi-Naive Children and Adolescents | December 2012 | August 2014 |
| NCT01765127 | Completed | An Observational Modified Prescription-event Monitoring Study of Asenapine (Sycrest) | January 2012 | January 2018 | |
| NCT01822678 | Completed | Phase 2 | Efficacy and Safety of Eslicarbazepine Acetate (BIA 2-093) in Acute Manic Episodes Associated With Bipolar I Disorder | December 2005 | November 2006 |
| NCT01825837 | Completed | Phase 2 | Efficacy, Safety, and Tolerability of Eslicarbazepine Acetate in the Recurrence Prevention of Bipolar I Disorder | March 2006 | June 2007 |
| NCT01828931 | Completed | N/A | Lifestyle Intervention for Diabetes and Weight Management in Psychosis | December 2012 | November 2015 |
| NCT01977300 | Completed | Phase 3 | Atypical Antipsychotics for Continuation and Maintenance Treatment After an Acute Manic Episode | January 2003 | August 2011 |
| NCT01986114 | Completed | Phase 3 | A Long-Term Study of SM-13496 in Patients With Bipolar I Disorder. | January 29, 2014 | February 17, 2018 |
| NCT01998516 | Completed | Emotional Intelligence in Schizophrenia and Bipolar-I- Disorder | December 2013 | July 31, 2017 | |
| NCT02147379 | Completed | Phase 3 | Lurasidone and Cognition in Bipolar I Disorder | May 2014 | January 12, 2017 |
| NCT02593643 | Completed | Early Phase 1 | Effect of Ketamine vs. Active Placebo on Suicidal Ideation in Depressed Inpatients With Major Depressive Disorder or Bipolar Depression. | January 2016 | April 2017 |
| NCT02722967 | Completed | Phase 2 | Exploratory Trial to Assess the Functionality of an Integrated Call Center for the Digital Medicine System | March 2016 | September 2016 |
| NCT03088462 | Completed | N/A | LiveWell: A Mobile Intervention for Bipolar Disorder | March 20, 2017 | April 10, 2021 |
| NCT03156504 | Completed | Phase 4 | The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression. | June 1, 2017 | March 12, 2020 |
| NCT03187769 | Completed | Phase 3 | Study to Evaluate the Efficacy of ALKS 3831 on Body Weight in Young Adults Who Have Been Recently Diagnosed With Schizophrenia, Schizophreniform, or Bipolar I Disorder | June 8, 2017 | January 3, 2022 |
| NCT00982020 | Completed | Phase 4 | Study in Adolescents With Schizophrenia or Bipolar Disorder | September 2009 | May 2013 |
| NCT00094432 | Completed | Phase 3 | A Study of Aripiprazole in Patients With Bipolar I Disorder With a Major Depressive Episode | June 2004 | November 2006 |
| NCT00107731 | Completed | Phase 3 | Efficacy & Safety of Seroquel Plus Mood Stabilizer in the Maintenance of Bipolar I Disorder | April 2004 | October 2006 |
| NCT00114686 | Completed | Phase 3 | Efficacy and Safety of Quetiapine Fumarate (SEROQUEL®) in the Treatment of Alcohol Dependency in Patients With Bipolar Disorder | January 2006 | April 2007 |
| NCT00141505 | Completed | Phase 2 | PK Effects of Bifeprunox & Valproate in Bipolar I | February 2005 | December 2006 |
| NCT00177164 | Completed | Phase 3 | Risperdal Consta for Bipolar Disorder | November 2003 | December 2009 |
| NCT03201757 | Completed | Phase 3 | Study to Evaluate the Long-term Safety, Tolerability, and Durability of Treatment Effect of ALKS 3831 | June 15, 2017 | September 6, 2023 |
| NCT03257865 | Completed | Phase 3 | A Trial to Assess Brexpiprazole Versus Placebo for the Treatment of Acute Manic Episodes, Associated With Bipolar I Disorder | September 19, 2017 | January 22, 2019 |
| NCT03259555 | Completed | Phase 3 | A Trial to Assess Brexpiprazole Versus Placebo for the Treatment of Acute Manic Episodes Associated With Bipolar I Disorder | September 14, 2017 | January 2, 2019 |
| NCT03287869 | Completed | Phase 3 | A Trial to Evaluate the Safety and Tolerability of Brexpiprazole in the Treatment of Participants With Bipolar I Disorder. | October 24, 2017 | July 31, 2019 |
| NCT03292848 | Completed | Phase 1 | Trial to Assess the Pharmacokinetics, Safety, Tolerability of Oral Brexpiprazole in Children (6 to <13 Years Old) With Central Nervous System Disorders | October 10, 2017 | May 21, 2018 |
| NCT03334721 | Completed | Phase 2 | Gabapentin for Bipolar & Cannabis Use Disorders | October 1, 2017 | July 1, 2019 |
| NCT03573297 | Completed | Phase 3 | A Cariprazine Study in the Prevention of Relapse in Bipolar I Disorder Patients Whose Current Episode is Manic or Depressive, With or Without Mixed Features | June 15, 2018 | September 5, 2022 |
| NCT03630822 | Completed | N/A | Multicenter, Randomized, Comparative and Prospective Study Evaluating the Impact on the Care Path of an Editorial Program Accompanied by Advance Directives in Psychiatry (DAP) for People Suffering From Schizophrenia, Bipolar I Disorder or Schizoaffective Disorder | January 2, 2019 | January 2, 2022 |
| NCT03854409 | Completed | Phase 1 | A Trial of Single- and Multiple-doses of Aripiprazole in Adult Subjects With Schizophrenia or Bipolar I Disorder | January 31, 2019 | February 20, 2020 |
| NCT04030143 | Completed | Phase 1/Phase 2 | A Trial of Multiple-doses of Aripiprazole in Adults With Schizophrenia or Bipolar 1 Disorder | August 1, 2019 | July 8, 2020 |
| NCT04127058 | Completed | Phase 1 | Evaluating a New Iloperidone Titration Scheme in Bipolar I Disorder or Schizophrenia | October 7, 2019 | November 27, 2019 |
| NCT04819776 | Completed | Phase 3 | Evaluation of Efficacy and Safety of Iloperidone in the Acute Treatment of Manic or Mixed Episodes Associated With Bipolar I Disorder | March 22, 2021 | August 16, 2023 |
| NCT04987658 | Completed | Phase 1 | Phase 1 Study of OLZ/SAM in Pediatric Subjects With Bipolar I Disorder | July 22, 2021 | August 11, 2023 |
| NCT05340504 | Completed | Phase 2 | Evaluating the Hypothesized Mechanism of Action of N-acetylcysteine for Bipolar Disorder | May 13, 2022 | June 21, 2023 |
| NCT05375214 | Completed | N/A | iTBS in Bipolar I Depression | March 3, 2023 | November 22, 2023 |
| NCT05683431 | Completed | N/A | Using Neuroplasticity-Based Computerized Training to Improve Emotion Regulation in Bipolar Disorder (BRAINS) | March 22, 2019 | December 16, 2021 |
| NCT05878808 | Completed | Obsessions and Suicidality in Youth With Bipolar 1 Disorder | February 1, 2022 | January 5, 2023 | |
| NCT06372210 | Completed | N/A | A Trial to Assess a Wearable Patch's Functioning to Detect Medication Ingestion | June 26, 2023 | July 19, 2023 |
| NCT04987229 | Enrolling by invitation | Phase 3 | Long-term Safety Extension Study of OLZ/SAM in Pediatric Subjects | October 22, 2021 | September 2027 |
| NCT06433635 | Not yet recruiting | Phase 4 | Sequential Multiple Assignment Randomized Trial for Bipolar Depression | September 1, 2024 | February 28, 2030 |
| NCT05705063 | Not yet recruiting | N/A | Impact of a Ketogenic Diet on Metabolic and Psychiatric Health in Patients With Bipolar Illness | January 30, 2023 | December 30, 2024 |
| NCT05956483 | Not yet recruiting | Study to Assess Accuracy of Rapid Mood Screener in Adult Participants With Unipolar Major Depressive Disorder or Bipolar 1 Disorder in Real World Setting | July 15, 2023 | June 28, 2024 | |
| NCT04315792 | Recruiting | Phase 3 | Evaluate Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients | March 23, 2020 | May 31, 2024 |
| NCT03943537 | Recruiting | Phase 2 | Effects of Intranasal Insulin on Neuroimaging Markers and Cognition in Patients With Psychotic Disorders | October 1, 2019 | January 26, 2024 |
| NCT05956340 | Recruiting | N/A | A Study of Spoken Language in Mania | April 19, 2023 | August 2024 |
| NCT06129500 | Recruiting | N/A | CBT for Problematic Impulsive Behaviours in Bipolar Disorder: A Case Series / CBT-PIB | August 17, 2023 | June 24, 2024 |
| NCT05004896 | Recruiting | Phase 2 | Ketamine for Treatment-Resistant Bipolar Disorder | July 4, 2022 | December 31, 2025 |
| NCT05064319 | Recruiting | Phase 2 | Gabapentin for Restoring GABA/Glutamate Homeostasis in Co-occurring Bipolar and Cannabis Use Disorders | February 24, 2022 | June 30, 2026 |
| NCT05837104 | Recruiting | Phase 2 | Efficacy and Safety of Magnesium Vitamin B6 in First Episode Bipolar Disorder | December 13, 2023 | December 2025 |
| NCT05303064 | Recruiting | Phase 3 | Study to Evaluate Weight Gain as Assessed by Change in BMI Z-score in Pediatric Subjects With Schizophrenia or Bipolar I Disorder | June 30, 2022 | September 2026 |
| NCT05339074 | Recruiting | Phase 2 | Maintenance Ketamine Infusions for Treatment-Resistant Bipolar Depression | August 11, 2022 | February 28, 2026 |
| NCT06221852 | Recruiting | N/A | Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder | March 12, 2024 | December 30, 2027 |
| NCT05340686 | Recruiting | N/A | Braining- Aerobic Physical Activity as Add on Treatment in Bipolar Depression | October 26, 2022 | April 20, 2027 |
| NCT06256367 | Recruiting | Observational Study of Oral Cariprazine Capsules to Assess Change in Disease Activity in Adult Participants With Bipolar I Disorder | April 18, 2024 | July 31, 2025 | |
| NCT04578756 | Recruiting | Phase 3 | Open-Label, Flexible-dose Study to Evaluate the Long-Term Safety and Tolerability of Cariprazine in the Treatment of Pediatric Participants With Schizophrenia, Bipolar I Disorder, or Autism Spectrum Disorder | February 1, 2021 | September 15, 2025 |
| NCT05427123 | Recruiting | Children's Bipolar Network Treatment Trial I | July 1, 2022 | July 1, 2026 | |
| NCT04771299 | Recruiting | Phase 3 | Assessing the Role of Cariprazine in Improving Cognition in Euthymic Bipolar Patients | July 7, 2021 | September 30, 2026 |
| NCT05648591 | Recruiting | Phase 4 | Safety and Tolerability of Open-Labeled Iloperidone in Adolescents | May 24, 2023 | September 2024 |
| NCT06273774 | Recruiting | Phase 1 | A Study of MK-8189 in Participants With Bipolar I Disorder (MK-8189-020) | April 8, 2024 | September 10, 2024 |
| NCT04777357 | Recruiting | Phase 3 | A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder. | April 28, 2021 | January 29, 2025 |
| NCT05977023 | Recruiting | Phase 2 | NMDA Receptor Modulation for the Treatment of Bipolar I Disorder | October 4, 2023 | December 2027 |
| NCT02491307 | Terminated | N/A | Ginger.io Behavioral Health Study | July 2015 | October 2015 |
| NCT01824602 | Terminated | Phase 2 | Efficacy and Safety of Eslicarbazepine Acetate (BIA 2-093) in Acute Manic Episodes Associated With Bipolar I Disorder | February 2006 | November 2006 |
| NCT00857818 | Terminated | Phase 3 | Trial Comparing the Effects of Aripiprazole With Those of Standard of Care on Non-HDL Cholesterol in Patients With Schizophrenia or Bipolar I Disorder Who Have Metabolic Syndrome | April 2009 | March 2010 |
| NCT03192631 | Unknown status | N/A | Financial Incentives to Improve Acceptance of Antipsychotic Injections | July 1, 2017 | December 31, 2021 |
| NCT04211428 | Unknown status | A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Bipolar Disorder | March 2, 2020 | July 2023 | |
| NCT04561622 | Unknown status | Emotional Proactive Processing in Bipolar Disorder | October 1, 2020 | October 1, 2022 | |
| NCT04907279 | Unknown status | Aripiprazole Once-Monthly in Hospitalized Patients (INITIATE) | November 1, 2021 | June 2023 | |
| NCT05420792 | Unknown status | N/A | The Effect of Interpersonal Relationships and Social Rhythm Therapy Individuals With Bipolar Disorder | August 1, 2021 | October 1, 2022 |
| NCT00608075 | Unknown status | Phase 4 | Neurofunctional and Neurochemical Markers of Treatment Response in Bipolar Disorder | April 2007 | July 2017 |
| NCT03603561 | Unknown status | N/A | Continuous Theta Burst Stimulation as an add-on Treatment for Bipolar Depression | August 1, 2018 | July 2020 |
| NCT01710163 | Unknown status | Phase 4 | Potentiation of Quetiapine Treatment With Lithium or Aripiprazole in Bipolar 1 Nonresponders Patients | June 2012 | June 2015 |
| NCT03919760 | Unknown status | Early Psychosis Intervention - Spreading Evidence-based Treatment | January 3, 2020 | May 31, 2024 | |
| NCT01495156 | Withdrawn | Phase 4 | Study of the Efficacy of Adjunctive Lithium Treatment for the Treatment of Psychotic Mania | September 2011 | September 2015 |
- Disase is a (Disease Ontology)
- DOID:3312
- Cross Reference ID (Disease Ontology)
- ICD9CM:296.50
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:49468007
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0236773