Head and Neck Neoplasms

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Information
Disease name
Head and Neck Neoplasms
Disease ID
Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT05218824 Active, not recruiting Collection of Head Images During Radiotherapy February 14, 2022 December 31, 2024
NCT02918955 Active, not recruiting Phase 3 Definitive Chemo-Radiotherapy for Regionally Advanced Head and Neck Cancer With or Without Up-front Neck Dissection October 2016 May 2025
NCT02568267 Active, not recruiting Phase 2 Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions) November 19, 2015 April 1, 2025
NCT03765918 Active, not recruiting Phase 3 Study of Pembrolizumab Given Prior to Surgery and in Combination With Radiotherapy Given Post-surgery for Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-689) December 17, 2018 September 10, 2026
NCT06110195 Active, not recruiting Phase 1 Study of Xevinapant With Radiation and Chemotherapy for Patients With Head and Neck Cancer January 24, 2024 October 2027
NCT03082534 Active, not recruiting Phase 2 Pembrolizumab Combined With Cetuximab for Treatment of Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma March 28, 2017 May 2024
NCT02281955 Active, not recruiting Phase 2 De-intensification of Radiation and Chemotherapy for Low-Risk HPV-related Oropharyngeal SCC: Follow-up Study August 2014 November 2024
NCT04222972 Active, not recruiting Phase 3 A Study of Pralsetinib Versus Standard of Care for First-Line Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC) July 24, 2020 June 30, 2025
NCT03691714 Active, not recruiting Phase 2 Durvalumab (MEDI4736) With Cetuximab in Previously Treated Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma October 23, 2018 December 2024
NCT03818061 Active, not recruiting Phase 2 Atezolizumab and Bevacizumab in Patients With Recurrent or Metastatic Squamous-cell Carcinoma of the Head and Neck March 26, 2019 March 1, 2024
NCT02229656 Active, not recruiting Phase 1 Olaparib and Radiotherapy in Head and Neck Cancer September 24, 2014 January 2024
NCT03040999 Active, not recruiting Phase 3 Study of Pembrolizumab (MK-3475) or Placebo With Chemoradiation in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-412/KEYNOTE-412) April 5, 2017 August 16, 2024
NCT01856478 Active, not recruiting Phase 3 LUX-Head&Neck 3: Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer After Platinum Based Chemotherapy May 23, 2013 August 31, 2024
NCT03401840 Active, not recruiting N/A STEREO-POSTOP 01 (PostOperative Hypofractionated Stereotactic Body Radiotherapy ) - GORTEC 2017-03 January 23, 2018 January 2024
NCT05511714 Available Expanded Access [11C] Methionine PET Imaging
NCT00239304 Completed Phase 1/Phase 2 Gefitinib (Iressa) in Combo With Chemoradiation in Patients With Locally Advanced Head & Neck Cancer June 2003 March 2006
NCT00243347 Completed Phase 1 The Effects of AZD2171 in Patients With Non-Small Cell Lung Cancer or Head & Neck Cancer December 2005 July 2009
NCT00248235 Completed Phase 2/Phase 3 Resistance Exercise Training for the Shoulder and Neck Following Surgery for Head and Neck Cancer September 2005 January 2009
NCT00252473 Completed Phase 2 S-Frame CT Immobilization Masks For Patients Undergoing Radiation Therapy For Head and Neck Cancer January 2005 June 2009
NCT00261703 Completed Phase 2/Phase 3 Docetaxel in Head and Neck Cancer December 2002 July 2010
NCT00268671 Completed Phase 1/Phase 2 Docetaxel in Squamous Cell Carcinoma of the Head and Neck (TAX + Cisplatin in SCCHN) August 2003 April 2006
NCT00328458 Completed Phase 1 EPO906 Plus Radiation Therapy for the Treatment of Cancer Patients February 2004 July 2009
NCT00357149 Completed Phase 2 Neoadjuvant Docetaxel Plus Cisplatin and 5-fluorouracil (TPF) Followed by Concomitant Chemoradiotherapy and Chemoradiotherapy Alone in Locally Advanced Squamous Cell Carcinoma of the Head and Neck Patients (SCCHNS) January 2003
NCT00358930 Completed Phase 2 A Study of ARQ 501 in Patients With Squamous Cell Carcinoma of the Head and Neck July 2006 August 2007
NCT00375414 Completed N/A Role of Prophylactic Antibiotics in New Introducer PEG-Gastropexy October 2003 April 2007
NCT00400426 Completed Phase 2 DAHANCA 20 Palliative Radiotherapy for Head and Neck Cancer November 2006 June 2012
NCT00401323 Completed Phase 2/Phase 3 Taxotere (Docetaxel) in 1st Line Treatment of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma January 1998 June 2003
NCT00402545 Completed Phase 1 C-TPF in Patients With Newly Diagnosed Locally Advanced Squamous Cell Carcinoma of the Head and Neck January 2007 July 2009
NCT00415194 Completed Phase 3 A Study for Patients With Head and Neck Cancer December 2006 March 2010
NCT00496236 Completed Phase 1/Phase 2 Radiotherapy, Cetuximab, and Injections of TNFerade™ Biologic for Elderly or Frail Patients With Head and Neck Cancer
NCT00496535 Completed Phase 1/Phase 2 A Study of TNFerade™ Biologic With Concomitant Radiotherapy, Fluorouracil, and Hydroxyurea (TNF-FHX) in Patients With Head and Neck Cancer
NCT00514943 Completed Phase 2 BIBW 2992 (Afatinib) in Head & Neck Cancer August 2007 July 2013
NCT00519077 Completed Phase 2 Phase II Study of Skin Toxicity Dosing of IRESSA (Gefitinib) in Squamous Cell Carcinoma of the Head and Neck March 2005 May 2013
NCT00521521 Completed Phase 2 Study of Combination Docetaxel and Radiotherapy With or Without Cisplatin to Treat Local Advanced Head and Neck Cancer July 2001
NCT00721799 Completed Phase 2 F-18 Fluorothymidine PET Imaging for Early Evaluation of Response to Therapy in Head & Neck Cancer Patients March 1, 2008 December 31, 2014
NCT00768664 Completed Phase 2 Open-Label Trial Of Oral PF-00299804 By Continuous Dosing In Patients With Recurrent Or Metastatic Head And Neck Squamous Cell Cancer November 4, 2008 April 18, 2012
NCT00772681 Completed Phase 4 Efficacy of Chemoradiotherapy After Neoadjuvant Cisplatin and Docetaxel in the Nasopharynx Carcinoma October 2004 March 2008
NCT00841191 Completed Phase 1/Phase 2 A Safety, Efficacy and Pharmacokinetic Study of Siltuximab (CNTO 328) in Participants With Solid Tumors March 2009 April 2011
NCT00916097 Completed Phase 2 NPC Study : TAX + CIS Neoadjuvant in Patients With Loco Regionally Advanced Undifferentiated Carcinoma of Nasopharyngeal Type (UCNT) July 2002 November 2005
NCT00923481 Completed Phase 2 A Broad Multi-histology Phase II Study of the Multi-Kinase Inhibitor R935788 (Fostamatinib Disodium) in Advanced Colorectal, Non-small Cell Lung, Head and Neck Hepatocellular and Renal Cell Carcinomas, and Pheochromocytoma and Thyroid Tumors (Multi-H... April 2009 January 2012
NCT00978250 Completed Phase 2 A Multi-Histology Phase II Study of 5-Fluoro-2'-Deoxycytidine With Tetrahydrouridine (FdCyd + THU) August 20, 2009 April 11, 2019
NCT00993512 Completed Phase 1 Safety Study of Amphinex Based Photochemical Internalisation (PCI) of Bleomycin in Patients With Cutaneous Cancer August 2009 May 2011
NCT00995293 Completed Phase 3 Taxotere (Docetaxel) New Indication: Squamous Cell Carcinoma of the Head and Neck (SCCHN) Treatment Registration Trial August 27, 2009 January 26, 2018
NCT01195922 Completed Phase 1/Phase 2 Rapamycin Therapy in Head and Neck Squamous Cell Carcinoma August 2010 December 2015
NCT00050388 Completed Phase 3 Phase II Trial of Allovectin-7® for Head and Neck Cancer June 2002
NCT00057512 Completed Phase 1 Study of Intralesional Injection of M4N in Patients With Refractory Malignant Tumors of the Head and Neck January 2003 December 2003
NCT00093041 Completed Phase 1/Phase 2 Zalutumumab in Head and Neck Cancer December 1, 2003 January 12, 2005
NCT00094081 Completed Phase 3 Concomitant Radiation and Cisplatin With and Without Tirapazamine in Treatment of Advanced Head and Neck Cancer October 2002 September 2006
NCT00100204 Completed Salivary Proteins in Disease and Health December 21, 2004 April 19, 2011
NCT00123097 Completed Phase 3 Clinical Trial of New Elastomer for Maxillofacial Prosthetics February 2005 August 2009
NCT00135161 Completed Phase 1 Feasibility Study of Incorporating 18F-FDG-PET Imaging in Radiotherapy for Head and Neck Cancer September 2003 August 2015
NCT00138827 Completed Phase 4 Mouth Care Regimes During Radiotherapy November 1999 March 2003
NCT00144976 Completed N/A Study of Biological Effect of Tarceva (OSI-774) for Patients Stricken by ENT Epidermoid Carcinoma October 2003 December 2006
NCT00147862 Completed Phase 3 Does Tranexamic Acid Administration Reduce Blood Loss During Head and Neck Surgery? May 2005 January 2007
NCT00163176 Completed Value of FLT-PET Before and During Radiotherapy in Head and Neck Tumors July 2005 December 2010
NCT00180180 Completed Tumor Hypoxia of Head-and-neck Cancer Underwent Radiation Therapy Measured With F-18-FMISO July 2006 October 2018
NCT00184860 Completed N/A The Role of CT-PET-MRI Image Fusion in Determining Radiation Treatment Volumes of Head-and-Neck Cancer Patients June 2003
NCT00199160 Completed Phase 2 Efficacy and Activity of BAY 43-9006 in Patients With Recurrent and/or Metastatic Head and Neck Cancer April 2005 June 2010
NCT01025518 Completed N/A DAHANCA 25A: Resistance Training and Dietary Supplements as Intervention for Regaining Muscle Mass Following Radiotherapy in Head and Neck Cancer Patients September 2009 January 2012
NCT01057589 Completed Phase 2 A Study for Patients With Recurrent or Metastatic Squamous Cell Head and Neck Cancer February 2010 October 2012
NCT01059357 Completed N/A Transoral Robotic Surgery (TORS) for Oral and Laryngopharyngeal Lesions Using Da Vinci Robotic Surgical System June 2010 October 2014
NCT01065844 Completed Phase 2 Nelfinavir in Recurrent Adenoid Cystic Cancer of the Head and Neck October 2009 November 2017
NCT01087970 Completed Phase 2 A Study for Participants With Recurrent or Metastatic Squamous Cell Head and Neck Cancer August 2010 August 2013
NCT01187173 Completed The Fibrosis-Lymphedema Continuum in Head and Neck Cancer July 2010 November 2014
NCT01235052 Completed N/A Prognostic Evaluation of 18fmiso Pet-ct in Head and Neck Cancer June 2009 July 2014
NCT01283334 Completed Phase 1/Phase 2 A Study of Carboplatin, Cetuximab and RAD001 in Advanced Head and Neck Cancer January 2011 November 2014
NCT01345682 Completed Phase 3 LUX-Head&Neck 1: A Phase III Trial of Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic (R/M) Head and Neck Squamous Cell Cancer After Platinum Based Chemotherapy January 5, 2012 December 6, 2016
NCT01530997 Completed Phase 2 De-intensification of Radiation & Chemotherapy in Low-Risk Human Papillomavirus-related Oropharyngeal Squamous Cell Ca February 7, 2012 November 2019
NCT01566435 Completed Phase 2 Induction Chemotherapy With ACF Followed by Chemoradiation Therapy for Adv. Head & Neck Cancer August 9, 2012 October 31, 2019
NCT01639911 Completed Phase 1 Phase I Study of MLN8237 and Pazopanib in Patients With Solid Tumors August 14, 2013 July 28, 2016
NCT01737450 Completed Phase 2 Activity and Safety Study of BKM120 in Monotherapy in Patient With Metastatic Head and Neck Cancer Recurrent or Progressive January 2013 March 2019
NCT02017288 Completed Study to Evaluate the Natural History of Head and Neck Cancer Precursors in Taiwan November 18, 2013 February 4, 2021
NCT02085941 Completed N/A Image-guided Cryoablation of Head, Neck and Spine Tumors February 2015 July 2021
NCT02107235 Completed Phase 1 Platinum-based Chemoradiotherapy and Rigosertib in Head and Neck Cancer January 2014 January 2015
NCT02188563 Completed N/A A Comprehensive Smoking Cessation Intervention Duration Radiation for Upper Aerodigestive Cancers May 2014 May 2016
NCT02204033 Completed Phase 1 Dose Escalation Study With 99mTC - or 186 Re-labelled Humanised Monoclonal Antibody (hMAb) BIWA 4 in Patients With Head and Neck Cancer March 1999
NCT02251730 Completed Phase 2 Smoking Cessation in Head and Neck Cancer Patients Receiving Curative Radiation Therapy August 2014 May 2016
NCT02254018 Completed Phase 1 Single Dose Escalation Study of Bivatuzumab Mertansine in Patients With Advanced Squamous Cell Carcinoma of the Head and Neck September 1, 2002
NCT02284802 Completed N/A Early Detection of Tumors of the Digestive Tract by Confocal Endomicroscopy September 10, 2014 March 10, 2023
NCT02324335 Completed Phase 2 Study of the Effects of Brilacidin Oral Rinse on Radiation-induced Oral Mucositis in Patients With Head and Neck Cancer August 14, 2014 November 22, 2017
NCT02332161 Completed Leg Function and ADL After ALT Reconstruction for Head and Neck Cancer January 2014 June 26, 2017
NCT02335112 Completed N/A Irreversible Electroporation(IRE) For Unresectable Head and Neck Neoplasms January 1, 2015 January 1, 2021
NCT02397486 Completed Phase 2 The Impact of Pentoxifylline and Vitamin E on Radiotherapy-induced Toxicity in Head & Neck Cancer Patients May 2, 2015 June 30, 2018
NCT02439892 Completed N/A Rehabilitation for Head and Neck Cancer April 2015 April 1, 2017
NCT02442375 Completed Phase 3 Uniform FDG-PET Guided Gradient Dose Prescription to Reduce Late Radiation Toxicity June 2016 March 8, 2024
NCT02460471 Completed Phase 2 Palliative Radiotherapy Protocol in Head and Neck Cancer June 2011 April 2015
NCT02478138 Completed N/A Sentinel Lymph Node Mapping of Oral Cancer Using Near-Infrared Fluorescence Imaging May 2015 January 8, 2024
NCT02545322 Completed N/A Image Guided Adaptive Radiotherapy in the Head-and-neck Region February 2012 August 2013
NCT02548377 Completed N/A Remote Ischemic Preconditioning in Head and Neck Cancer Reconstruction - A Randomized Controlled Trial September 29, 2015 February 26, 2018
NCT02555644 Completed Phase 1 A Study of Prexasertib (LY2606368) With Chemotherapy and Radiation in Participants With Head and Neck Cancer February 24, 2016 January 14, 2019
NCT02597582 Completed Phase 4 LigaSure Small Jaw® Versus Conventional Neck Dissection in Head and Neck Cancer Patients January 2014 October 2015
NCT02622880 Completed Phase 4 Comparison of Two Immunomodulatory Formulas on the Number of Postoperative Infections in Head & Neck Cancer Patients February 2013 June 2014
NCT02643550 Completed Phase 1/Phase 2 Study of Monalizumab and Cetuximab in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck December 2015 March 28, 2023
NCT02647021 Completed N/A Therapeutic Resistance Group Exercise Training for Head & Neck Cancer Survivors March 31, 2016 March 30, 2020
NCT02836769 Completed N/A Development and Evaluation of Rehabilitation Consult for Survivors of Head and Neck Cancer January 2016 May 2018
NCT02857413 Completed Frequency of Xerostomia and Their Management in Upper Aerodigestive Tract Cancer Patients After the End of Radiotherapy January 2016 July 2016
NCT02941276 Completed N/A A Trial Looking at Treating Dry Mouth After Radiotherapy for Head and Neck Cancer November 2011 November 2014
NCT02946021 Completed Phase 1/Phase 2 Response to Intermittent Pneumatic Compression Therapy in Head and Neck Cancer-Related Lymphedema October 2016 February 2018
NCT02966509 Completed N/A Engagement of Patients With Advanced Cancer August 2013 December 2016
NCT03003637 Completed Phase 1/Phase 2 ImmunoModulation by the Combination of Ipilimumab and Nivolumab Neoadjuvant to Surgery In Advanced or Recurrent Head and Neck Carcinoma February 28, 2017 February 12, 2021
NCT03034603 Completed N/A The Safety and Efficacy Test of Nutri-PEITC Jelly in Head and Neck Cancer Patients August 2014 January 2023
NCT03037385 Completed Phase 1/Phase 2 Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Participants With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors March 17, 2017 March 21, 2024
NCT03047174 Completed N/A Radiotherapy Related Skin Toxicity: Mepitel® vs. Standard Care in Patients With Locally Advanced Head-and-Neck Cancer May 9, 2017 July 16, 2019
NCT03077243 Completed Phase 2 P53 Mutational Status and cf HPV DNA for the Management of HPV-associated OPSCC December 2016 December 14, 2022
NCT03092934 Completed Phase 1/Phase 2 A Study of AK-01 (LY3295668) in Solid Tumors May 29, 2017 April 20, 2020
NCT03225157 Completed Hearing Loss and the Effects of Statin Drugs in People With Head and Neck Squamous Cell Carcinoma Treated With Cisplatin Chemoradiation November 3, 2017 February 28, 2020
NCT03252509 Completed N/A Outpatient Percutaneous Radiologic Gastrostomy in Patients With Head and Neck Tumors March 20, 2017 November 21, 2018
NCT03292250 Completed Phase 2 Korean Cancer Study Group: Translational bIomarker Driven UMbrella Project for Head and Neck (TRIUMPH), Esophageal Squamous Cell Carcinoma- Part 1 (HNSCC)] September 10, 2017 March 10, 2022
NCT03332160 Completed N/A A Pilot Study to Evaluate the Feasibility and Potential Effectiveness of the Flexitouch System Head and Neck Treatment January 2, 2018 July 31, 2019
NCT03345719 Completed The Translational Research Image-Guided Operating Room (TRIGORA): Intraoperative 3D Imaging for Head & Neck Surgical Patients October 4, 2012 March 31, 2019
NCT03443258 Completed N/A Needs Assessment Tool Integrated in Clinical Practice of Head and Neck Cancer Rehabilitation June 11, 2018 November 30, 2019
NCT03546322 Completed Customized Registry Tool for Tracking Adherence to Clinical Guidelines for Head and Neck Cancers June 1, 2018 March 30, 2022
NCT03547388 Completed Phase 1 Moderate Whole Body Hyperthermia for Patients Undergoing Re-irradiation for Head and Neck Cancer -Influence on the Tumor Microenvironment July 1, 2018 May 4, 2020
NCT03549494 Completed Phase 2 Evaluation of Ocoxin®-Viusid® in Advanced Stomach Cancer and Gastric Esophagogastric Junction October 25, 2018 February 15, 2023
NCT03672799 Completed N/A Rehabilitation Planning Consult Phase II Trial January 7, 2019 July 7, 2021
NCT03695510 Completed Phase 2 Afatinib and Pembrolizumab for Head and Neck Squamous Cell Carcinoma (ALPHA Study) January 24, 2019 April 14, 2022
NCT03753932 Completed N/A Impact of Fixed Dentures in Head and Neck Cancer (IMFDHAC) March 1, 2013 September 17, 2021
NCT04208334 Completed Phase 2 The Effect of Curcumin for Treatment of Cancer Anorexia-Cachexia Syndrome in Patients With Stage III-IV of Head and Neck Cancer February 13, 2020 March 31, 2021
NCT04247282 Completed Phase 1/Phase 2 Anti-PD-L1/TGF-beta Trap (M7824) Alone and in Combination With TriAd Vaccine and N-803 for Resectable Head and Neck Squamous Cell Carcinoma Not Associated With Human Papillomavirus Infection June 9, 2020 June 12, 2023
NCT04260074 Completed Epigenetic Changes in Head and Neck Cancer March 11, 2020 July 14, 2021
NCT04266015 Completed N/A Anabolic Effects of Intraoperative Feeding in Reconstruction Surgery April 16, 2020 April 13, 2022
NCT04420689 Completed Phase 1/Phase 2 A Study of ALM-488 to Highlight Nerves in Patients Undergoing Head & Neck Surgery June 18, 2020 February 15, 2022
NCT04525066 Completed Phase 2 Phonosurgical Augmentation After Laser Resection of Early Glottic Carcinoma August 13, 2013 August 13, 2018
NCT04758026 Completed H&N Cancer; Survivorship and Late Effects October 10, 2018 October 10, 2020
NCT04782726 Completed N/A Radiation Therapy Plan Quality Improvement Using Ideal Theoretical Isodose Distribution December 16, 2021 January 20, 2023
NCT04866498 Completed Pharmacotherapy Personalization of Cancer Patients July 1, 2016 March 31, 2021
NCT05068687 Completed N/A Peroperative Assessment of Malignancies of the Head and Neck Using High-resolution 18F-FDG-PET/CT August 28, 2020 September 30, 2022
NCT05227807 Completed N/A The Efficacy of Mouth Exercise in Oral Cancer Patients After Receiving Surgery July 7, 2012 December 12, 2014
NCT05269342 Completed N/A Nurse-led Exercise Improves Shoulder Pain, Shoulder Disability, and Quality of Life in Head and Neck Cancer September 14, 2017 September 9, 2018
NCT05614843 Completed N/A Photobiomodulation Therapy in Patients With Head and Neck Cancer Post-Radiotherapy October 1, 2022 July 31, 2023
NCT05962944 Completed Remote Rapid Onsite Evaluation (ROSE) for Head and Neck Fine Needle Aspirations (FNA) October 25, 2022 July 24, 2023
NCT06446570 Completed Phase 2 Phase II Study of Durvalumab(MEDI4736) + Tremelimumab in Pulmonary Sarcomatoid Carcinoma September 10, 2017 June 3, 2021
NCT06458517 Not yet recruiting N/A Evaluation of Two Methods of Administration of Photobiomodulation in the Context of the Prevention and Treatment of Mucositis Induced by Radiotherapy, During the Treatment of Head and Neck Cancers September 2, 2024 May 2, 2026
NCT03051906 Not yet recruiting Phase 1/Phase 2 Durvalumab, Cetuximab and Radiotherapy in Head Neck Cancer January 2018 January 2025
NCT05341206 Not yet recruiting Phase 2 Evaluation the Effects of Herbal Gargle for Chemoradiotherapy-induced Oral Mucositis of Head & Neck Cancer, a Pilot Study. April 15, 2022 December 31, 2025
NCT06289049 Not yet recruiting Phase 2 Heavy Strength Training in Head and Neck Cancer Survivors September 2024 April 2026
NCT06398899 Not yet recruiting N/A Sugammadex v.s. Neostigmine/Glycopyrrolate May 1, 2024 January 31, 2025
NCT06347185 Not yet recruiting N/A Simultaneous Care in Recurrent and/or Metastatic Head and Neck Cancer: the SupCare Study September 2024 December 2028
NCT05664906 Not yet recruiting Phase 1/Phase 2 Evaluating Chinese Medicine Oral Rinse for Irradiated Oral Mucositis in Head & Neck Cancer Patients January 31, 2023 November 30, 2024
NCT06215612 Not yet recruiting N/A ctDNA and MRI Parameters in Head and Neck Cancer February 2024 February 2030
NCT04405154 Not yet recruiting Phase 2 A Study of Concomitant Camrelizumab With Chemoradiation for Locally Advanced Head and Neck Cancer June 1, 2020 May 31, 2025
NCT03975465 Recruiting N/A EMST and Swallowing in Long-Term Survivors of HNCA September 10, 2018 October 1, 2025
NCT03981068 Recruiting N/A DAHANCA 37. Re-irradiation With Proton Radiotherapy September 1, 2019 August 30, 2025
NCT04075305 Recruiting The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study February 1, 2019 May 1, 2025
NCT04028479 Recruiting The Registry of Oncology Outcomes Associated With Testing and Treatment May 5, 2021 October 1, 2031
NCT05187091 Recruiting Phase 3 The SWOAR Trial Sparing of Swallowing and Aspiration Related Organs at Risk & Submandibular Gland With Intensity Modulated Radiotherapy Versus Standard IMRT in Head and Neck Squamous Cell Carcinomas July 11, 2021 June 2025
NCT06335342 Recruiting Radiotherapy Treatments for Neoplasms in the Head and Neck Region February 22, 2018 December 31, 2024
NCT05412849 Recruiting Radiation Field, Dose and Fractionation Related to Mandibular Complications January 1, 2023 July 2025
NCT05418842 Recruiting N/A Exercise Prehabilitation in Patients With Head and Neck Squamous-cell Carcinoma: The FIT4TREAT Trial June 1, 2021 December 31, 2024
NCT05106608 Recruiting N/A Photobiomodulation Therapy Plus M-health in Head and Neck Cancer Patients: LAXER Study July 13, 2022 July 2025
NCT05420948 Recruiting Phase 2 A Study of Pembrolizumab in Combination With Chemotherapy for Head and Neck Cancer October 17, 2022 December 1, 2026
NCT02395367 Recruiting Prospective, Observational, Real-world Oral Malignant Tumors Study March 2015 March 2025
NCT04612075 Recruiting The EMINENCE Study - PET/MR Imaging of Head Neck Cancer January 12, 2021 December 2028
NCT05432297 Recruiting N/A Preventive Physical Activity Intervention in Head and Neck Cancer January 2, 2023 December 2031
NCT05483400 Recruiting Phase 2 Open Label Phase 2 Basket Trial With Atezolizumab and Tiragolumab in Solid Tumors October 18, 2023 September 2027
NCT05260671 Recruiting Phase 2 Penpulimab in Combination With Cetuximab as First-line Treatment in R/M SCCHN January 25, 2022 December 25, 2026
NCT05022667 Recruiting N/A Assessing Benefits of Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Total Thyroidectomy December 1, 2021 August 2024
NCT06365866 Recruiting N/A Evaluate the Efficacy of Adding Intraluminal Brachytherapy After CCRT for Local-regional Thoracic Esophageal Cancer. February 19, 2024 December 2024
NCT05544136 Recruiting Phase 2 A Study of Decreasing Radiation Therapy and Chemotherapy in People With Head and Neck Cancer September 12, 2022 March 12, 2027
NCT03343236 Recruiting Nutrition and Inflammation in Patients With Head and Neck Cancer November 1, 2015 December 31, 2027
NCT04598087 Recruiting N/A Prehabilitation and Recovery After Head and Neck Cancer Surgery February 9, 2022 December 31, 2024
NCT06237881 Recruiting Phase 1/Phase 2 A Phase 1/2 Study of KSQ-001EX, Autologous Tumor Infiltrating Lymphocytes Engineered to Inactivate the SOCS1 Gene, in Patients With Select Advanced Solid Tumors January 31, 2024 January 1, 2029
NCT03429036 Recruiting Biospecimen Procurement for Head and Neck Disorders May 23, 2018 December 3, 2026
NCT05647122 Recruiting Phase 1 First in Human Study of AZD9592 in Solid Tumors December 22, 2022 October 29, 2025
NCT02557048 Recruiting Head and Neck Cancer in Children: A Retrospective Study January 10, 2019 December 2023
NCT05308732 Recruiting Phase 1 Safety and Tolerability of the Use of Copaiba in Patients With Oral Cancer Submitted to Radiotherapy May 11, 2021 April 2024
NCT05763615 Recruiting N/A 3D Modeling of the Cervico-facial Region and Cranial Nerve Tractography: IMAG 2 ORL Project May 10, 2023 May 2025
NCT05785247 Recruiting ENHANCE - Evaluating the Implementation of Head and Neck Cancer E-health June 14, 2023 March 31, 2025
NCT04429542 Recruiting Phase 1 Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors June 1, 2020 June 1, 2025
NCT06303180 Recruiting NIDCD Otolaryngology Clinical Protocol Biospecimen Bank March 4, 2024 December 30, 2033
NCT05811936 Recruiting N/A The SNAP Tool for Head and Neck Cancer Survivor-Caregiver Dyads August 23, 2023 May 31, 2026
NCT06216171 Recruiting N/A Adaptive Radiotherapy in Head and Neck Tumor Patients January 25, 2024 January 30, 2028
NCT05944237 Recruiting Phase 1/Phase 2 HTL0039732 in Participants With Advanced Solid Tumours July 13, 2023 September 2026
NCT05954676 Recruiting N/A Online Peri-operative Education Program for Patients Undergoing Major Head & Neck Surgery July 17, 2023 October 31, 2024
NCT03622164 Recruiting N/A Unilateral Neck Radiotherapy in Head and Neck Cancer December 21, 2018 September 2028
NCT05980598 Recruiting Phase 2 TransCon (TC) TLR7/8 Agonist, TC IL-2 β/γ, Pembrolizumab Prior to Surgery for Advanced Head and Neck Squamous Cell Carcinoma September 29, 2023 July 30, 2027
NCT06291610 Recruiting N/A Feasibility Testing a Decision-support Intervention for Clinical Trials February 19, 2024 December 31, 2026
NCT00200486 Recruiting Molecular and Genomic Profiling of Head and Neck Tumors May 2002 December 2025
NCT03914378 Recruiting The Effects on Auditory Function of RADiotherapy and Chemotherapy Treatments for Head and Neck Tumours (EARAD) May 1, 2019 December 2026
NCT04188951 Recruiting Early Phase 1 HFHS-1801-A Pilot Study of Immunotherapy as Consolidation Therapy for Patients With Recurrent Head and Neck Cancer October 4, 2019 December 30, 2023
NCT03916809 Recruiting N/A EMST in Patients Undergoing CRT for HNCA July 12, 2017 August 1, 2024
NCT03942380 Recruiting N/A Cell-free Tumor DNA in Head and Neck Cancer Patients February 1, 2017 February 1, 2025
NCT04124198 Recruiting N/A Quality of Life After Primary TORS vs IMRT for Patients With Early-stage Oropharyngeal Squamous Cell Carcinoma March 1, 2019 January 2029
NCT02817113 Terminated Phase 1 Study of NC-6004 in Combination With 5-FU and Cetuximab in Patients With Head and Neck Cancer June 2016 September 2018
NCT02900248 Terminated CureOne Registry: Advanced Malignancy or Myelodysplasia, Tested by Standard Sequencing and Treated by Physician Choice October 2, 2017 March 29, 2019
NCT00557206 Terminated Phase 2 Oxaliplatin and Docetaxel for Recurrent or Metastatic Head and Neck Cancer April 2005 November 2009
NCT02975739 Terminated N/A Feasibility of Holmium-166 Micro Brachytherapy in Head and Neck Tumors September 2016 September 5, 2018
NCT03020823 Terminated Phase 2 To Evaluate the Efficacy and Safety of SCB01A in Subjects With r/m Squamous Cell Head and Neck Cancer April 30, 2017 November 20, 2018
NCT00506324 Terminated Oropharyngeal Function After Radiotherapy With IMRT June 2006 June 2014
NCT00412776 Terminated Phase 2/Phase 3 Study of Proxinium Plus Best Supportive Care Versus Best Supportive Care for Patients With Advanced Head and Neck Cancer December 2005 April 2008
NCT03286972 Terminated PET/MRI to Enhance Precision Guidance in Head and Neck Radiation Treatment Planning September 12, 2017 June 20, 2019
NCT00073450 Terminated Phase 2 Study of Lonafarnib in Patients With Recurrent Squamous Cell Carcinoma of the Head and Neck (Study P02530) September 2003 June 2004
NCT03321903 Terminated EPR Tumor Oximetry With CE India Ink August 30, 2017 October 27, 2019
NCT03515824 Terminated Phase 1 Study of MK-1697 in Participants With Advanced Solid Tumors (MK-1697-001) August 13, 2018 February 18, 2020
NCT03540953 Terminated N/A Endoscopic Injection of Mitomycin C for the Treatment of Pharyngoesophageal Stenosis January 5, 2015 January 5, 2018
NCT00358007 Terminated Phase 2 Use of Cone Beam Kilovoltage Imaging in Patients Receiving Radiation Therapy for Head and Neck Cancer March 2007 September 2010
NCT03780725 Terminated Phase 1 This Study Tests How BI 754111 is Distributed in Patients With Advanced Non-small Cell Lung Cancer or Patients With Head and Neck Cancer Who Are Treated With BI 754091 January 22, 2019 December 8, 2020
NCT00272181 Terminated Phase 2 Study of Proxinium for Treating Patients With Squamous Cell Head and Neck Cancer January 2006 October 2007
NCT00011492 Terminated Patient Evaluation for Head and Neck Surgery Branch Studies March 12, 2001 November 23, 2020
NCT01216020 Terminated Phase 2 Cetuximab Plus Radiotherapy Versus Cisplatin Plus Radiotherapy in Locally Advanced Head and Neck Cancer October 2010 May 20, 2015
NCT01333852 Terminated Phase 2 Metformin Plus Paclitaxel for Metastatic or Recurrent Head and Neck Cancer February 2011 April 2014
NCT01345669 Terminated Phase 3 LUX-Head&Neck 2: A Phase III Trial of Afatinib (BIBW 2992) Versus Placebo for the Treatment of Head and Neck Squamous Cell Cancer After Treatment With Chemo-radiotherapy October 17, 2011 September 12, 2016
NCT01479348 Terminated Early Phase 1 Imaging Study for FdCyd and THU Cancer Treatment November 1, 2011 January 11, 2019
NCT01975766 Terminated N/A Ketogenic Diet Phase 1 for Head & Neck Cancer January 2014 July 11, 2017
NCT02015650 Terminated Phase 4 Cetuximab Compared to Mitomycin-C and 5-Fluorouracil for Locally Advanced Squamous Cell Carcinomas of the Head and Neck April 2014 April 19, 2016
NCT02045186 Terminated N/A Monitoring of Oral Human Papillomavirus Infection (HPV) in HPV-positive Oropharyngeal Squamous Cell Carcinoma (OPSCC) December 2013 November 2014
NCT02131155 Terminated Phase 3 LUX-Head & Neck 4: Afatinib (BIBW 2992) Versus Placebo for the Treatment of Head and Neck Squamous Cell Cancer After Treatment With Chemo-radiotherapy July 17, 2014 August 22, 2016
NCT02183246 Terminated Phase 3 Porfiromycin Used as an Adjuvant to Radiation Therapy in Postoperative Head and Neck Cancer Patients May 2000
NCT02209701 Terminated Phase 1 Pharmacokinetic Study of Porfiromycin in Head and Neck Cancer and Other Cancer Patients With Solid Tumors December 1999
NCT00937612 Terminated N/A Postoperative Concurrent Chemoradiation for Head and Neck Cancer With Multiple Minor Risk June 2008 March 2014
NCT04634825 Terminated Phase 2 Enoblituzumab Plus Retifanlimab or Tebotelimab in Head and Neck Cancer March 17, 2021 July 29, 2022
NCT02421458 Terminated N/A Comparing Two Palliative Schemes of Radiotherapy for Head and Neck Cancer November 2015 November 2018
NCT04644315 Terminated Phase 2 A Home-Based Approach Study to Evaluate the Efficacy and Safety of Alectinib in Locally-Advanced or Metastatic ALK-Positive Solid Tumors May 24, 2021 May 16, 2022
NCT02485470 Terminated Phase 2 Benefits of MPACT in Locally Advanced Head and Neck Cancer Patients Undergoing Chemoradiotherapy February 2016 October 2018
NCT04996147 Terminated Acute and Long-term Impact of Cancer Treatment on Head and Neck Cancer Patients: FIT4TREATMENT June 1, 2019 March 3, 2020
NCT02557529 Terminated N/A Progressive Resistance Training in Head and Neck Cancer Patients During Concomitant Chemoradiotherapy August 2015 January 2020
NCT02629029 Terminated N/A Multi-Modality Imaging for Head & Neck Cancer Free Flap Design Assessment May 30, 2015 November 27, 2020
NCT02633800 Terminated Phase 2 Patritumab With Cetuximab and a Platinum Agent for Squamous Cell Carcinoma (Cancer) of the Head and Neck (SCCHN ) December 22, 2015 February 21, 2018
NCT00159978 Terminated Validation of 18F-MISO-PET and 18F-FLT-PET July 2005 December 2013
NCT01447134 Unknown status RGD-K5 in Head and Neck Cancer Patients June 2011 June 2014
NCT02854735 Unknown status Total Body Composition in Detection of Nutrition Depletion in Head and Neck Patients February 2015 January 2018
NCT00627562 Unknown status N/A A Pilot Study of the Use of the DaVinci Robotic System for Otorhinolaryngology-Head and Neck Surgery July 2007 December 2017
NCT02943252 Unknown status Phase 2 The Clinical Study of Apatinib Plus S1 for Patients With Advanced Non-squamous Head and Neck Cancer October 2016 October 2021
NCT04013178 Unknown status N/A Exercise After Radiation for Head & Neck Cancer March 31, 2017 June 26, 2020
NCT01260480 Unknown status Phase 2 An Efficacy and Safety Study to Assess [18F]-ML-10 in Detecting Response of Tumors to Chemotherapy and Radiation December 2010
NCT03989830 Unknown status Phase 2 Second-Line Chemotherapy Combined With Endostatin for Recurrent/Metastatic HN Epithelial Tumors July 29, 2019 June 30, 2022
NCT01301248 Unknown status Phase 2 Cisplatin Chemoradiation With or Without Cetuximab for Locoregionally Advanced Squamous Cell Carcinomas (SCC) of the Head and Neck March 2008 June 2011
NCT04697446 Unknown status External Control, Observational, Retrospective Study Comparing Pralsetinib to Best Available Therapy in Patients With RET-Fusion Positive NSCLC December 1, 2020 October 31, 2021
NCT01985438 Unknown status N/A A Trial Comparing Two Modalities of Prophylactic Nutritional Support During Treatment for Head and Neck Cancer November 2013 June 2015
NCT05396183 Unknown status Accuracy and Safety of Coplanar Template Assistance for Head and Neck Biopsies. May 25, 2022 March 25, 2024
NCT01488669 Unknown status N/A Robot Assisted Supraomohyoid Neck Dissection Via Retroauricular Approach January 2011 September 2013
NCT04117139 Unknown status N/A The Diagnostic Value of PET/MRI in Head and Neck Cancer October 1, 2019 September 30, 2022
NCT00982436 Unknown status Phase 1/Phase 2 Neoadjuvant Cisplatin/Docetaxel (CDDP/TXT) and Chemoradiation for Head and Neck Cancer September 2009 December 2012
NCT05318872 Unknown status Prospective Evaluation of ENDOSWIR Device Versus Pathology for Squamous Cell Carcinoma of Upper Aerodigestive Tract (ENDOSWIR-VADS) April 11, 2022 June 30, 2023
NCT02989259 Unknown status Phase 2 Apatinib for Advanced Non-squamous Head and Neck Cancer December 2016 December 2021
NCT02047487 Unknown status After Induction Chemotherapy of DP Plus DDP Concurrent Radiotherapy With and Without Bevacizumab Study May 2013 August 2018
NCT03799744 Unknown status Phase 1 Safety,Tolerability,and Efficacy of VCN-01 With Durvalumab in R/M Head and Neck Squamous Cell Carcinoma March 20, 2019 January 31, 2023
NCT04878692 Unknown status N/A Evaluation of a Cosmetic Product to Preserve Skin Conditions When Using Anti-EGFR Cancer Therapies June 1, 2021 July 1, 2022
NCT02630264 Unknown status Phase 3 E10A for the Treatment of Squamous Cell Carcinoma of the Head and Neck June 2013 December 2016
NCT03786172 Unknown status N/A Efficacy of Smoking Cessation Intervention for Head and Neck Cancer Patients January 2015 December 2019
NCT00308880 Unknown status Phase 3 Tranexamic Acid and Head and Neck Surgery Patients March 2006 March 2007
NCT02960724 Unknown status Phase 2 uPAR PET/CT for Staging Advanced and Localised Oral and Oropharyngeal Cancer November 2016 August 2018
NCT02837679 Unknown status N/A Oncogeriatric Intervention and Follow-up at Home January 2016 January 2023
NCT02241876 Unknown status Phase 4 THE USE OF N-ACETYLCYSTEINE ATTENUATING CISPLATIN-INDUCED TOXICITIES BY OXIDATIVE STRESS October 2014
NCT03678649 Unknown status Phase 2 A Prospective Randomized Trial of Capecitabine Treatment in Patients With HNSCC September 10, 2018 December 30, 2023
NCT00813631 Unknown status Phase 4 The Effect on an Ionic Silver Dressing in Head and Neck Patients With Malignant Fungating Wound January 2009 November 2009
NCT02283489 Unknown status Phase 2 Recombinant Human Endostatin Adenovirus Combined With Chemotherapy for Advanced Head and Neck Malignant Tumors October 2014 October 2016
NCT04435938 Unknown status Phase 2 A Study of SBRT for Squamous Cell Carcinoma of the Head and Neck September 10, 2020 December 2022
NCT03356587 Unknown status Phase 2 A Biomarker-driven, Open Label, Single Arm, Multicentre Phase II Study of Abemaciclib in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Who Failed to Platinum-based Therapy October 16, 2017 December 31, 2020
NCT03171558 Unknown status N/A Gastric Pull up Versus Free Flap Reconstruction for Laryngo-pharyngeal Defects March 16, 2017 March 2023
NCT03114202 Unknown status N/A Effects of Nutritional Counseling on Nutritional Status and Quality of Life of Head and Neck Cancer Patients April 18, 2017 October 1, 2018
NCT03875833 Withdrawn N/A Prospective Analysis of Effect of Collagen Wrap Conduit on Radial and Ulnar Nerve Function Following Radial/Ulnar Forearm Free Flap Harvest October 9, 2020 January 1, 2024
NCT01175499 Withdrawn N/A Concordance of Two Endoscopic Procedures for Diagnosis of Carcinoma of the Upper Aerodigestive Tract July 2010
NCT03561324 Withdrawn N/A Intraoperative Imaging of a PET Positive Lymph Node(s) Using 18FDG and a Dual-Mode, Hand-Held Intraoperative Imager June 20, 2018 January 22, 2020
NCT01621048 Withdrawn Evaluation of Treatment Related Toxicity After Radiotherapy for Head and Neck Cancer June 2012 December 2016
NCT00038038 Withdrawn N/A Assessment of Head and Neck Tumor Hypoxia Using 18F-Fluoromisonidazole January 1994 June 2003
NCT01020864 Withdrawn Phase 2 Cetuximab in Combination With Chemotherapy for Patients With Head and Neck Cancer January 2010 January 2012
NCT01262859 Withdrawn Phase 2 Pilot Study for Locally Advanced Head and Neck Cancer December 2010 July 2011
NCT00363441 Withdrawn Phase 2/Phase 3 A Study of Conventional 3D Radiation vs. Intensity-Modulated Radiation in Squamous Cell Cancer of the Head and Neck
NCT03906838 Withdrawn Early Phase 1 Regional Anesthesia Block in Fibula Free Flap Reconstruction January 1, 2020 November 30, 2020
NCT01747512 Withdrawn Phase 2 An Imaging Study in Patients With Thyroid Cancer or Head and Neck Cancer With Pertechnetate Made in a Cyclotron (C-PERT)
NCT02216669 Withdrawn Phase 1 Trial to Determine Optimal Phase II Dose of the Oral Dual CAIX Inhibitor/ Radiosensitizer March 2017 July 2017
NCT02908386 Withdrawn ROCOCO - Adaptive IMRT Versus IMPT in Head and Neck Cancer November 2015 November 2016
NCT03971760 Withdrawn N/A Ideal Drainage Output of Post-operative Neck Suction Drain November 2021 June 2022
MeSH unique ID (MeSH (Medical Subject Headings))
D006258