pulmonary hypertension

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Information
Disease name
pulmonary hypertension
Disease ID
DOID:6432
Description
"A hypertension characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries." [url:https\://en.wikipedia.org/wiki/Pulmonary_hypertension, url:https\://www.ncbi.nlm.nih.gov/pubmed/19555858]
Disease area statistics
Chromosome band
Gene symbol Chromosome Start Stop The number of variant
NDUFA10 2 239,972,240 240,025,389 8
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT04744584 Active, not recruiting Medication Reconciliation in Pulmonary Hypertension February 15, 2021 June 15, 2024
NCT01961232 Active, not recruiting Trans-pulmonary Biomarkers in Pulmonary Hypertension August 2013 June 2026
NCT05337943 Active, not recruiting N/A Cognitive Behavioral Therapy and Light Therapy January 12, 2023 December 31, 2024
NCT05838846 Active, not recruiting Phase 2/Phase 3 Inhaled Versus Intravenous Milrinone for Patients Undergoing Mitral Valve Replacement Surgery April 1, 2023 March 2025
NCT06023134 Active, not recruiting Clinical Characteristics and Outcomes of Patients With Pulmonary Hypertension Associated Right Heart Failure January 1, 2015 December 1, 2025
NCT05447390 Active, not recruiting N/A Evaluation of the Strength of Handgrip in Patients With Pulmonary Artery Hypertension September 1, 2020 June 1, 2023
NCT03905421 Active, not recruiting Quality of Life Assessed With the PAH SYMPACT Questionnaire March 6, 2019 March 2025
NCT05572996 Available Inhaled Treprostinil Expanded Access Program in Pulmonary Hypertension Associated With Interstitial Lung Disease
NCT04432545 Available Infusion of Allogeneic Mesenchymal Stem Cells in Patients With Diffuse Cutaneous Systemic Sclerosis With Refractory Pulmonary Involvement
NCT05356052 Available Expanded Access for Patients With Pulmonary Hypertension Associated With Pulmonary Fibrosis
NCT00080457 Completed Phase 3 Safety and Efficacy Study of Sitaxentan Sodium (Thelin™) in Patients With Pulmonary Arterial Hypertension May 2003 January 2005
NCT00086463 Completed Phase 2 Trial of Iloprost Inhaled Solution as Add-On Therapy With Bosentan in Subjects With Pulmonary Arterial Hypertension (PAH) June 2004 January 2006
NCT00091598 Completed Phase 3 ARIES - Ambrisentan in Patients With Moderate to Severe Pulmonary Arterial Hypertension (PAH) January 2004 February 2006
NCT00091715 Completed Phase 3 Efficacy and Safety of Oral Bosentan in Pulmonary Arterial Hypertension Class II April 2004 February 2011
NCT00109681 Completed Phase 2 Inhaled Iloprost in Adults With Abnormal Pulmonary Pressure and Associated With Idiopathic Pulmonary Fibrosis April 2005 October 2006
NCT00113152 Completed Heart Disease in Sickle Cell Anemia June 2, 2005 October 2, 2007
NCT00125918 Completed Phase 3 PHIRST-1: Tadalafil in the Treatment of Pulmonary Arterial Hypertension August 2005 August 2007
NCT00139217 Completed N/A NO Need to Ventilate: A Trial of Non-invasive Inhaled Nitric Oxide in Persistent Pulmonary Hypertension of the Newborn August 2005 September 2007
NCT06186713 Completed Pulmonary Hypertension on Prognosis of Acute Myocardial Infarction Patients With Reduced Left Ventricular Function March 30, 2023 August 1, 2023
NCT00147199 Completed Phase 3 Clinical Investigation Into Inhaled Treprostinil Sodium in Patients With Severe Pulmonary Arterial Hypertension (PAH) June 2005 October 2007
NCT00159861 Completed Phase 3 The Efficacy and Safety of Sildenafil Citrate Used in Combination With Intravenous Epoprostenol in PAH July 2003 January 2006
NCT00159887 Completed Phase 3 Study to Assess the Longterm Safety of Sildenafil Citrate in Patients With Pulmonary Arterial Hypertension December 2002 February 2007
NCT00180713 Completed Phase 1/Phase 2 Simvastatin as a Treatment for Pulmonary Hypertension October 2005 May 2009
NCT00190333 Completed Phase 3 Serotonin Transporter Inhibitor Escitalopram in Pulmonary Hypertension June 2005 December 2008
NCT00205426 Completed Phase 4 Natrecor for Pulmonary Hypertension in Lung Transplants August 2005 May 2006
NCT00235521 Completed N/A Iloprost-Study: Comparison of Nitric Oxide to Iloprost (Ventavis) for Treatment of Pulmonary Hypertension in Children After Cardiopulmonary Bypass Surgery May 2005 October 2008
NCT00270478 Completed Phase 1 Hydroxyurea and Erythropoietin to Treat Sickle Cell Anemia December 21, 2005 August 31, 2009
NCT05767918 Completed StratosPHere (Non-interventional Study) April 14, 2021 September 30, 2022
NCT00314548 Completed N/A Inhaled Prostacyclin for Adult Respiratory Distress Syndrome (ARDS) and Pulmonary Hypertension May 2006 July 2009
NCT00319111 Completed Phase 3 Bosentan in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH) January 2006 April 2009
NCT00325403 Completed Phase 3 FREEDOM - M: Oral Treprostinil as Monotherapy for the Treatment of Pulmonary Arterial Hypertension (PAH) October 2006 April 2011
NCT00325442 Completed Phase 3 FREEDOM-C: Oral Treprostinil in Combination With an Endothelin Receptor Antagonist (ERA) and/or a Phosphodiesterase-5 (PDE-5) Inhibitor for the Treatment of Pulmonary Arterial Hypertension (PAH) October 2006 December 2010
NCT00334490 Completed Phase 2 Does Oral Sildenafil (Viagra) Decrease Mean Pulmonary Artery Pressure After Cardiac Surgery? March 2005 May 2009
NCT00345774 Completed Phase 2 Safety and Effectiveness of PRX-08066 in Patients With Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease June 2006 June 2007
NCT05496504 Completed Pulmonary Hypertension and Arrhythmia September 1, 2013 December 31, 2015
NCT00352430 Completed Phase 1 Cardiopulmonary Function Assessment and NO-Based Therapies for Patients With Hemolysis-Associated Pulmonary Hypertension July 9, 2006 March 10, 2010
NCT05478226 Completed ADAMTSL4 in Idiopathic Pulmonary Hypertension and CTEPH July 1, 2018 July 1, 2022
NCT00367523 Completed Pulmonary Hypertension in Patients With Sickle Cell Disease in Nigeria June 15, 2006 September 28, 2017
NCT00370214 Completed REVEAL Registry™: Registry to Evaluate Early And Long-term PAH Disease Management March 2006 December 2012
NCT00373360 Completed Phase 4 Safety, Efficacy and Treatment Satisfaction in Patients With PAH Rapidly Switched From Epoprostenol to Remodulin September 2006 January 2008
NCT05475028 Completed Network Medicine Approaches to Classify Heart Failure With PReserved Ejection Fraction by Signatures of DNA Methylation and Point-of-carE Risk calculaTors (PRESMET) September 14, 2021 June 14, 2022
NCT00377949 Completed Multi-center, Web Based Observational Study of Pulmonary Hypertension in Scleroderma Patients February 2005
NCT00380068 Completed Phase 3 Safety and Efficacy Study of Ambrisentan in Subjects With Pulmonary Hypertension August 2006 May 2009
NCT05458635 Completed N/A Predictors of Pulmonary Hypertension in Patients With Hypersensitivity Pneumonitis August 1, 2019 March 15, 2021
NCT00423592 Completed Phase 2 Phase 2 Study of Ambrisentan for Liver Function Test Rescue in Pulmonary Arterial Hypertension May 2005 March 2009
NCT00424021 Completed Phase 2 Phase 2 Extension Study of Ambrisentan in Pulmonary Arterial Hypertension April 2003 December 2009
NCT00432978 Completed Phase 1 Effect of Bosentan on Exercise Capacity at High Altitude July 2006 February 2007
NCT00452283 Completed Changes in Eye Pressure and Anterior Chamber Depth With Oral Endothelin Antagonist Therapy March 2007 May 2011
NCT00454207 Completed Phase 3 Open Label Study of Sildenafil in Patients With Pulmonary Arterial Hypertension April 2007 February 2009
NCT00457301 Completed Using Health-related Quality of Life (HRQL) in Routine Clinical Care July 2005 May 2008
NCT00464932 Completed Vasoactive Intestinal Peptide in COPD June 2003 July 2006
NCT05427253 Completed Phase 1 First-in-human Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of C106 in Healthy Subjects June 15, 2022 June 22, 2023
NCT00491803 Completed Phase 4 Sildenafil Effects on Pulmonary Haemodynamics and Gas Exchange in Chronic Obstructive Pulmonary Disease (COPD) June 2007 February 2009
NCT05256082 Completed N/A Impact of Face Masks on 6MWD in Patients With Pulmonary Hypertension November 15, 2020 March 31, 2022
NCT00495638 Completed Pulmonary Hypertension, Hypoxia and Sickle Cell Disease June 28, 2007 December 2, 2014
NCT00519870 Completed Phase 3 Losartan Therapy in Pulmonary Hypertension January 2005 July 2005
NCT00527163 Completed Role of Nitric Oxide in Malaria September 4, 2007 March 30, 2015
NCT00561223 Completed N/A Iloprost in Gas Exchange/Pulm Mechanics in Chronic Obstructive Pulmonary Disease (COPD) November 2006 October 31, 2012
NCT00566137 Completed Sleep Disturbances and Pulmonary Artery/Aorta Diameter in Scleroderma Patient February 2006 February 2007
NCT00575692 Completed Magnetic Resonance Imaging in the Diagnosis of Pulmonary Hypertension December 2006 December 2013
NCT05186987 Completed N/A Visa-versa! Breaking Instead of Pushing the Pedals-A February 15, 2022 September 30, 2023
NCT05176951 Completed Phase 2 A Study to Evaluate the Safety and Tolerability of Treprostinil Palmitil Inhalation Powder in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease December 22, 2022 March 14, 2024
NCT05128929 Completed Phase 2 Investigation of H01 in Adults With Pulmonary Hypertension Including Interstitial Lung Disease (The SATURN Study). April 1, 2022 September 29, 2023
NCT00614900 Completed Prevalence of Pulmonary Hypertension in COPD Patients March 2008 March 2011
NCT05103189 Completed N/A 4D-flow Cardiac MRI to Assess Pulmonary Arterial Pressure in Pulmonary Hypertension October 21, 2021 July 1, 2023
NCT00625963 Completed The Study Of CT Scans and Echo Parameters in Patients With PAH April 2007 July 2011
NCT05096819 Completed Evaluation of the Usefulness of Adopting Remote, Mobile-based 6MWT Among Hospital Outpatients (the 6-APPnow), Within the Constraints Imposed by the SARS-COV2 Pandemic September 1, 2021 October 6, 2023
NCT00666198 Completed Special Investigation For Long-Term Use Of Sildenafil (Regulatory Post Marketing Commitment Plan) May 2008 June 2015
NCT00675051 Completed Effect of Endothelin-1 Receptor Blockade on Circulating Endothelial Microparticles Levels in Patients With Pulmonary Hypertension March 2008 February 2009
NCT05082272 Completed The Role of Transthoracic Echocardiography in Diagnosis of Pulmonary Hypertension of Infants With Bronchopulmonary Dysplasia January 1, 2016 June 1, 2017
NCT00678821 Completed Phase 2 Aerobic Exercise in Patients With Pulmonary Hypertension June 12, 2008 September 23, 2015
NCT05001711 Completed N/A Acute Assessment of the Aria CV System in Patients With WHO Groups 2 and 3 Pulmonary Hypertension July 12, 2021 January 6, 2022
NCT04903704 Completed N/A Pulmonary Hypertension and Measurement of Exercise Capacity Remotely June 8, 2021 December 15, 2021
NCT04891354 Completed Phase 1 A First-in-Human Study to Assess the Safety and Tolerability of PDNO February 2, 2021 May 25, 2022
NCT04792879 Completed N/A Assessment of Peripheral Veins Doppler Ultrasound for Diagnosis of Acute Right Heart Failure in Suspicion or Follow-up of Pulmonary Hypertension June 14, 2021 November 21, 2022
NCT00718952 Completed Phase 3 The Efficacy and Safety of Vardenafil in the Treatment of Pulmonary Arterial Hypertension July 2008 February 2010
NCT04769635 Completed N/A CPAP Therapy in Obstructive Sleep Apnea Patients With Pulmonary Hypertension October 15, 2019 October 15, 2020
NCT00739375 Completed Phase 1 The Effect of Blood Flow in the Maturing Arteriovenous Access for Hemodialysis on the Development of Pulmonary Hypertension. September 2011 April 2012
NCT00759408 Completed Phase 2 The Role of Endothelin in Pulmonary Hypertension February 1999 June 2011
NCT04753112 Completed Phase 3 Treatment of PH With Angiotensin II Receptor Blocker and Neprilysin Inhibitor in HFpEF Patients With CardioMEMS Device October 29, 2020 September 20, 2021
NCT00777920 Completed Phase 3 Study of Ambrisentan in Participants With Pulmonary Hypertension November 17, 2008 September 11, 2019
NCT04663230 Completed Right Atrial Fibrosis in Pulmonary Hypertension April 30, 2021 November 30, 2023
NCT04633538 Completed Evaluation of a New 6 Minute Walk Test Smartphone App in Patients With Pulmonary Hypertension January 15, 2018 April 1, 2020
NCT00808912 Completed N/A Does Sildenafil Increase Exercise Performance in Air Pollution? December 2008 February 2010
NCT00810693 Completed Phase 3 A Study to Evaluate Efficacy and Safety of Oral BAY63-2521 in Patients With Pulmonary Arterial Hypertension (PAH) December 17, 2008 May 14, 2012
NCT04623528 Completed Characterization of the Liver Parenchyma Using Parametric T1 and T2 Magnetic Resonance Relaxometry January 2014 October 2020
NCT00820729 Completed Biomarkers in Pulmonary Hypertension Associated to Interstitial Lung Disease March 2009 March 2011
NCT04615754 Completed Phase 2 Ketones for Pulmonary Hypertension - Effects on Hemodynamics August 18, 2020 November 29, 2021
NCT04578223 Completed Platelet Reactivity and Treatment With Prostacyclin Analogues in Pulmonary Arterial Hypertension July 5, 2017 September 23, 2020
NCT00845013 Completed Epidemiology and Pathogenesis of HIV-Associated Pulmonary Hypertension November 2007 January 2021
NCT04524234 Completed Cardiac Dysfunction in Critically Ill Patients With COVID-19 April 20, 2020 September 30, 2020
NCT00851929 Completed Phase 2/Phase 3 Ambrisentan (Letairis) for Sarcoidosis Associated Pulmonary Hypertension November 2008 November 2011
NCT00855465 Completed Phase 3 A Study to Evaluate Efficacy and Safety of Oral BAY63-2521 in Patients With CTEPH. February 23, 2009 June 27, 2012
NCT00862043 Completed Phase 4 Sildenafil for Secondary Pulmonary Hypertension Due to Valvular Disease April 2009 July 2016
NCT00875940 Completed Right Ventricular Hypertrophy and Pulmonary Hypertension: A Correlation Analysis February 2008
NCT00878878 Completed Phase 4 Evaluate Effect of Optison on Pulmonary Artery Systolic Pressure (PASP) and Pulmonary Vascular Resistance (PVR). March 2009 July 2010
NCT00887978 Completed Phase 3 Efficacy and Safety of Oral UT-15C Tablets to Treat Pulmonary Arterial Hypertension June 2009 July 2011
NCT00893178 Completed Impact of Polymorphism on Pulmonary Pressure in Subjects With Pulmonary Hypertension of Different Cause December 2007 November 2021
NCT00909337 Completed N/A Early Therapy of Pulmonary Arterial Hypertension January 2008 June 2010
NCT00909467 Completed Early Recognition of Pulmonary Arterial Hypertension in Myelodysplastic and Myeloproliferative Diseases April 2009 November 2011
NCT00910429 Completed Phase 3 BAY63-2521 - Long-term Extension Study in Patients With Chronic Thromboembolic Pulmonary Hypertension July 1, 2009 August 19, 2019
NCT00926523 Completed Biomarkers in the Evaluation of Chronic Lung Disease June 2009 March 2011
NCT04402645 Completed Novel Echocardiographic Methods for Early Identification of Neonates at Risk for Chronic Pulmonary Hypertension August 31, 2017 April 1, 2024
NCT00927654 Completed Phase 3 Iloprost in High Risk Cardiac Surgical Patients June 2009 March 2012
NCT00946114 Completed To Provide Sildenafil Therapy To Eligible Adult Patients With Pulmonary Arterial Hypertension For 112 Weeks June 2006 March 2009
NCT00948012 Completed Exercise-induced Pulmonary Hypertension in Patients With Sickle-cell Anemia June 2006 November 2007
NCT00952302 Completed N/A Study of the Effects of Iron Levels on the Lungs at High Altitude October 2008 November 2008
NCT00960895 Completed Pulmonary Hypertension in Lymphangioleiomyomatosis August 2009 December 2010
NCT04391491 Completed Neuregulin-1 in Patient With Different Forms of Cardiovascular Diseases: a Pilot Study March 1, 2019 February 1, 2023
NCT04370873 Completed Phase 1 MK-5475 in Participants With Pulmonary Hypertension Associated With Chronic Obstructive Pulmonary Disease (PH-COPD) (MK-5475-006) June 5, 2020 January 12, 2022
NCT01023451 Completed Serum Brain Natriuretic Peptide Levels and Pulmonary Hypertension in Pediatric Sickle Cell Patients December 2009 June 2013
NCT01028651 Completed A Study to Assess the Safety and Efficacy of Treprostinil to Facilitate Liver Transplantation in Patients With Portopulmonary Hypertension January 2011 April 2013
NCT04053361 Completed N/A Catheter Ablation of Atrial Fibrillation in Patients With Pulmonary Hypertension Hypertension: a Randomised Study May 1, 2018 December 31, 2022
NCT01042158 Completed Phase 4 A Clinical Trial of Ambrisentan and Tadalafil in Pulmonary Arterial Hypertension Associated With Systemic Sclerosis January 2010 November 2014
NCT01048905 Completed Phase 2 Glutamine Therapy for Hemolysis-Associated Pulmonary Hypertension March 2009 March 2014
NCT01051960 Completed Phase 4 Exercise Induced Pulmonary Hypertension in Systemic Sclerosis and Treatment With Ambrisentan March 2009 January 2011
NCT01055405 Completed Phase 4 Study of Sildenafil Effects in Combination With Rehabilitation in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Associated Pulmonary Hypertension August 2008 January 2012
NCT01062282 Completed Hypertension Study of Ventavis® Inhalation Therapy in the Treatment of Patients With Pulmonary Arterial Hypertension (VENIS) July 2006 June 2009
NCT03974919 Completed Preoperative Pulmonary Systolic Pressure and Outcome After Non-cardiac Surgery:Threshold Analysis May 1, 2019 June 11, 2019
NCT01076296 Completed A Post-Marketing Study for On Label Evaluation of the GE Vscan Ultrasound Imaging System February 2010 July 2012
NCT01100008 Completed N/A Cardiac Magnetic Resonance Imaging and Pulmonary Perfusion September 2007 June 2014
NCT01104870 Completed Phase 2 A Dose Response Study of UT-15C SR in Patients With Exercise-Induced Pulmonary Hypertension April 2010 January 2013
NCT03901287 Completed N/A Quantitative Dual Energy Computed Tomography in Pulmonary Hypertension August 2, 2019 January 15, 2021
NCT03890627 Completed Thoracic Bio-reactance Measurement of Cardiac Output in Pulmonary Hypertension May 21, 2019 May 31, 2022
NCT01135706 Completed Fractal Analysis of the Pulmonary Arterial Tree in Pulmonary Hypertension April 2010 February 2012
NCT01156636 Completed Phase 2/Phase 3 Phosphodiesterase-5 (PDE5) Inhibition and Pulmonary Hypertension in Diastolic Heart Failure January 2006 December 2009
NCT03883048 Completed Idiopathic Bronchiectasis and Pulmonary Hypertension June 1, 2018 December 31, 2021
NCT01179334 Completed Phase 2 Evaluation of the Pharmacodynamic Effect of the Combination of Sildenafil and Riociguat on Blood Pressure and Other Safety Parameters. August 2010 May 2013
NCT01185730 Completed N/A Prospective Longitudinal Study of Patients With Idiopathic Pulmonary Arterial Hypertension, Family or Taking Anorectics January 2011 January 2016
NCT01197469 Completed Phase 2 Do Phosphodiesterase 5A Inhibitors Improve Exercise Capacity in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Pulmonary Hypertension? September 2010 September 2012
NCT03876509 Completed Non-invasive Diagnosis of Pulmonary Hypertension by Impedance Cardiography July 4, 2018 June 30, 2020
NCT03780803 Completed N/A Effect of Home Rehabilitation on State of Patients With PAH, HFREF and IHD February 1, 2016 September 30, 2021
NCT01260454 Completed Phase 2 The Qutenza Patch as Treatment for Disabling Treprostinil (Remodulin) Infusion Site Pain November 2010 April 2012
NCT01274481 Completed Phase 1 Iloprost Effects on Gas Exchange and Pulmonary Mechanics March 2011 July 2012
NCT03762577 Completed N/A Effects of Ground-based Walking Training in Pulmonary Hypertension December 10, 2018 March 4, 2020
NCT03727451 Completed Phase 2 A Dose Escalation Study to Assess the Safety and Efficacy of Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Fibrosis or Sarcoidosis January 30, 2019 June 15, 2022
NCT01287026 Completed Phase 1/Phase 2 Real-time MRI Right Heart Catheterization Using Passive Catheters February 23, 2011 March 21, 2019
NCT01306292 Completed Phase 2 Safety of SonoVue on Pulmonary Hemodynamics April 2011 November 2011
NCT01310751 Completed Phase 2/Phase 3 Study of Inhaled Iloprost in Pediatric Pulmonary Hypertension (PH) After Surgery January 2011 December 2013
NCT01313832 Completed N/A The Effect of Remote Ischemic Preconditioning on the Ischemic Reperfusion Injury in Infants With Ventricular Septal Defect and Pulmonary Hypertension December 2010 April 2011
NCT01320878 Completed Phase 2 Study of Inhaled Iloprost for the Treatment of Pulmonary Hypertension After Repair of Congenital Heart Disease October 2007 December 2009
NCT01324999 Completed Phase 2/Phase 3 Tadalafil for Sarcoidosis Associated Pulmonary Hypertension March 2011 October 2013
NCT01352065 Completed Phase 2/Phase 3 Characterization and Detection of Prolonged Endothelin Receptors Antagonists Administration January 2011 May 2013
NCT01364181 Completed Phase 3 The Impact of Udenafil on Exercise Capacity in Severe Chronic Obstructive Pulmonary Disease (COPD) Patients March 2010 May 2011
NCT02844036 Completed N/A Angioplasty of Distal Lesions for Carriers of Inoperable Post-embolic HTP June 2014 October 2017
NCT00004497 Completed Phase 3 Phase III Randomized Study of UT-15 in Patients With Primary Pulmonary Hypertension October 1998 September 2000
NCT00004805 Completed N/A Study of the Effect of Four Methods of Cardiopulmonary Resuscitation Instruction on Psychosocial Response of Parents With Infants at Risk of Sudden Death September 1991 August 1997
NCT00011648 Completed Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia February 19, 2008
NCT00023296 Completed Phase 1 Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension July 27, 2001 November 9, 2015
NCT00001313 Completed Evaluation of Patients With Known or Suspected Heart Disease May 10, 1992 January 6, 2009
NCT06240871 Completed Contrast Enhanced PA Pressure Measurements September 2013 September 2015
NCT00046319 Completed Phase 2 Study of BSF 208075 Evaluating Exercise Capacity in Patients With Pulmonary Arterial Hypertension September 2002 June 2003
NCT00058929 Completed Phase 4 A Transition Study From Flolan® to Remodulin® in Patients With Pulmonary Arterial Hypertension October 2002 August 2005
NCT06197256 Completed Cardiac Dysfunction in Critically Ill Covid-19 Patients May 7, 2020 February 11, 2021
NCT02865733 Completed Phase 3 Study of Remodulin® in Pediatric Pulmonary Hypertension With Single Ventricular Physiology After Fontan Surgery August 1, 2016 August 20, 2019
NCT02821156 Completed Study on the Use of Inhaled NO (iNO) September 2014 October 2015
NCT02829034 Completed Phase 4 Targeting Right Ventricle in Pulmonary Hypertension Gilead July 2016 January 2018
NCT02858791 Completed MIF- Thyroxine Interactions in the Pathogenesis of Pulmonary Arterial Hypertension February 2013 December 21, 2017
NCT01380054 Completed Pulmonary Hypertension, Quality of Life and Psychosocial Factors May 31, 2011 May 20, 2016
NCT03667794 Completed Evaluation of Novel Lung Function Parameters in Patients With Pulmonary Hypertension (PH) July 1, 2015 July 31, 2017
NCT01389271 Completed Inhaled Iloprost in the Treatment of Patients With Pulmonary Hypertension up to 4 Years February 3, 2011 June 18, 2018
NCT01393795 Completed Phase 2 Qutenza®-Remodulin® in Pulmonary Arterial Hypertension Patients August 2011 July 2012
NCT01394367 Completed N/A Influence of Respiratory and Exercise Therapy on Oxygen Uptake, Quality of Life and Right Ventricular Function in Severe Pulmonary Hypertension June 2010 May 2015
NCT01399983 Completed Standardization of 6 Minute Walk Test July 2011 October 2011
NCT01409122 Completed Phase 1 Safety, Tolerability, and PK Parameters of Sodium Nitrite Inhalation Solution in Healthy Subjects July 2011 January 2012
NCT03649932 Completed Phase 1 Enteral L Citrulline Supplementation in Preterm Infants - Safety, Efficacy and Dosing September 25, 2018 June 21, 2021
NCT01418248 Completed Study of Exercise and Heart Function in Patients With Heart Failure and Pulmonary Vascular Disease August 2011 August 2013
NCT01427192 Completed Phase 2 Treatment of Sleep Related Breathing Disorders in Patients With Pulmonary Hypertension November 2010 December 2012
NCT01431313 Completed Phase 2 Inhaled Nitrite in Subjects With Pulmonary Hypertension June 2012 October 2017
NCT03637218 Completed N/A Acute Exposure of High Altitude on Cardiac Output July 1, 2018 January 1, 2019
NCT03637192 Completed N/A Acute Exposure of High Altitude on Cognitive Function July 1, 2018 January 1, 2019
NCT01451255 Completed Early Detection of Pulmonary Arterial Hypertension Using Cardiac Magnetic Resonance Imaging August 2011 June 2014
NCT01457781 Completed Phase 2 Inhaled Nitric Oxide/INOpulse DS for Pulmonary Arterial Hypertension (PAH) April 2012 July 2016
NCT01463514 Completed N/A Noninvasive Determination of Cerebral Tissue Oxygenation in Pulmonary Hypertension September 2011 June 2014
NCT03637179 Completed N/A Acute Exposure to High Altitude on Pulmonary Artery Pressure and Right Heart Function (Echo) Under Exercise July 1, 2018 January 1, 2019
NCT03637166 Completed N/A Acute Exposure to High Altitude on Pulmonary Artery Pressure and Right Heart Function (Echo) July 1, 2018 January 1, 2019
NCT03637153 Completed N/A Acute Exposure to High Altitude on Exercise Capacity July 1, 2018 January 1, 2019
NCT03637140 Completed N/A Acute Exposure of Simulated Hypoxia on Pulmonary Artery Pressure and Right Heart Function (Echo) Under Exercise July 1, 2018 April 1, 2019
NCT01481350 Completed Phase 2 Sildenafil for Post-capillary Pulmonary Hypertension in Patients Undergoing Cardiac Surgery February 2012 December 2013
NCT01484899 Completed Smoking: a Risk Factor for Pulmonary Arterial Hypertension? September 2011 December 2012
NCT01491646 Completed Integrated Diagnostics Characterization of Right Ventricular Diastolic Flow Dynamics in Pulmonary Arterial Hypertension November 2010 October 2013
NCT01529502 Completed Phase 2 Pilot Study About the Harmful Effects of Blood Storage on Overweight People and the Role of iNO in This Setting March 2012 December 2013
NCT01539889 Completed Phase 1 Phase-I Study of Radiolabeled DFH-12 (PulmoBind) for Molecular Imaging of the Pulmonary Circulation December 2011 January 2013
NCT01554774 Completed Non-invasive Assessment of Pulmonary Vascular Resistance in Elderly Patients With Chronic Obstructive Pulmonary Disease March 2012 July 2012
NCT03637127 Completed N/A Acute Exposure of Simulated Hypoxia on Cognitive Function July 1, 2018 April 1, 2019
NCT03637114 Completed N/A Acute Exposure of Simulated Hypoxia on Blood and Tissue Oxygenation (aBGA, NIRS) August 1, 2018 April 1, 2019
NCT01571713 Completed Side Effects of Pulmonary Hypertension Medications August 2011 December 2020
NCT01586156 Completed N/A PAHTCH Pulmonary Arterial Hypertension Treatment With Carvedilol for Heart Failure (Carvedilol) December 2012 July 2016
NCT01598441 Completed Phase 3 Multicenter Study of Iloprost Inhaled in Pulmonary Hypertension After Repair of Congenital Heart Diseases (CHD) June 2012 November 2016
NCT01606839 Completed Noninvasive Measurement of Cardiac Output in Pulmonary Hypertension Using Inert Gas Rebreathing February 2012 February 2014
NCT03637088 Completed N/A Acute Exposure of Simulated Hypoxia on Pulmonary Artery Pressure and Right Heart Function (Echo) August 1, 2018 April 1, 2019
NCT01607515 Completed N/A Non Invasive Measurement of Cardiac Index by Impedance Cardiography March 2012 June 2015
NCT01615484 Completed N/A Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability September 2013 January 2017
NCT03600415 Completed N/A Acute Exposure to High Altitude on Blood and Tissue Oxygenation (ABGA, NIRS) July 1, 2018 January 1, 2019
NCT01621971 Completed Phase 3 Effect of Brief Nebulization of Milrinone on Pulmonary Arterial Pressure Before Cardiopulmonary Bypass on Mitral Valve Surgery Patients January 2003 January 2004
NCT03593096 Completed N/A Acute Exposure to High Altitude on Heart Rate and Ventilation During Exercise July 1, 2018 January 1, 2019
NCT01646541 Completed Symptomatic Pulmonary Arterial Hypertension After Mitral Valve Surgery July 2012 December 2014
NCT01725776 Completed Phase 2 Inhaled Milrinone in Cardiac Surgery December 2006 June 2012
NCT01726049 Completed Phase 3 Sildenafil in HFpEF (Heart Failure With Preserved Ejection Fraction) and PH October 2011 December 2014
NCT01728220 Completed Phase 2 Two-Part Dose-Confirming Study of Pulsed Inhaled Nitric Oxide in Subjects With WHO Group 3 Pulmonary Hypertension Associated With COPD December 2012 July 2014
NCT01729611 Completed Endothelial Function in Patients With Scleroderma or Cirrhosis With and Without Pulmonary Hypertension December 2013 April 2021
NCT03593083 Completed N/A Acute Excposure of High Altitude on ECG and Non-invasive Blood Pressure. July 1, 2018 January 1, 2019
NCT01758744 Completed Phase 1 Treatment of Pulmonary Hypertension Associated COPD With Inhaled Treprostinil-1 December 2012 July 2016
NCT01781858 Completed Study on the Clinical Course Of Pulmonary Embolism January 2008 July 2014
NCT01783093 Completed Tricuspid Regurgitant Jet Velocity as an Independent Marker for Mortality in Sickle Cell Anemia December 2009 January 2013
NCT01787162 Completed Screening for Pulmonary Vascular Changes in Patients With Chronic Myeloproliferative Diseases July 2012 June 2015
NCT01839110 Completed Phase 4 Targeting the Right Ventricle in Pulmonary Hypertension July 2013 January 2018
NCT03593005 Completed N/A Acute Exposure to High Altitude on Symptoms July 1, 2018 January 1, 2019
NCT03592979 Completed N/A Acute Exposure of Simulated Hypoxia on Heart Rate and Ventilation During Exercise July 1, 2018 April 1, 2019
NCT01862536 Completed Phase 2 Tadalafil for Pulmonary Hypertension Due to Chronic Lung Disease October 1, 2013 August 31, 2019
NCT03592927 Completed N/A Acute Exposure to Simulated Hypoxia on Exercise Capacity August 1, 2018 April 1, 2019
NCT01894035 Completed Non-interventional Multi-center Study on Patients Under Routine Treatment of Pulmonary Arterial Hypertension (PAH) With Inhaled Iloprost Using I-Neb as a Device for Inhalation September 23, 2013 April 13, 2017
NCT03581877 Completed Phase 4 Peripheral Systemic Thrombolysis Versus Catheter Directed Thrombolysis for Submassive PE January 28, 2019 March 19, 2023
NCT03581851 Completed N/A Acute Exposure of Simulated Hypoxia on ECG and Non-invasive Blood Pressure July 1, 2018 April 1, 2019
NCT03574675 Completed N/A Acute Exposure of Simulated Hypoxia on Cardiac Output May 2, 2018 April 1, 2019
NCT01917136 Completed Phase 2 11C-acetate/18Fluorodeoxyglucose-FDG PET/CT and Cardiac MRI in Pulmonary Hypertension August 2013 October 2018
NCT01932606 Completed Phase 2 Acute Effects of Inorganic Nitrite on Cardiovascular Hemodynamics in Heart Failure With Preserved Ejection Fraction August 2013 October 2014
NCT01948518 Completed N/A Effect of Sildenafil on Diffusion Capacity in Patients With PH and Parenchymal Lung Disease June 2009 June 2012
NCT03572036 Completed Phosphodiesterase Type-5 Inhibitor Therapy in Sickle Cell People With Pulmonary Hypertension June 20, 2018 April 16, 2021
NCT03565471 Completed Atrial Septal Defect - Exercise Capacity and Pulmonary Hypertension August 1, 2018 November 1, 2019
NCT03564522 Completed Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension April 1, 2017 July 28, 2023
NCT03438123 Completed N/A Data Collection Study for the Spectrum Dynamics Multi-purpose CZT SPECT Camera November 28, 2017 October 15, 2019
NCT02026531 Completed Phase 1/Phase 2 Novel MRI Techniques in the Evaluation of Pulmonary Vascular Disease November 2010 September 2015
NCT02036970 Completed Phase 2 Bardoxolone Methyl Evaluation in Patients With Pulmonary Hypertension (PH) - LARIAT May 31, 2014 May 16, 2018
NCT03404492 Completed N/A Effects of Cardiorespiratory Rehabilitation on the Right Ventricle in Pulmonary Hypertension June 12, 2018 July 5, 2020
NCT03396120 Completed The FVC/DLCO Ratio is a Useful Predictor of Pulmonary Hypertension in Patients With Interstitial Lung Disease February 2, 2017 December 31, 2017
NCT03385733 Completed N/A Inspiratory Muscle Training in Pulmonary Hypertension October 10, 2017 February 15, 2018
NCT02070991 Completed Phase 2 Clinical Study to Evaluate the Safety and Tolerability of Macitentan in Subjects With Combined Pre- and Post-capillary Pulmonary Hypertension (CpcPH) Due to Left Ventricular Dysfunction July 1, 2014 November 1, 2015
NCT03365479 Completed N/A Acute Response of Iloprost Inhalation Using the Breelib Nebulizer in Pulmonary Arterial Hypertension May 1, 2017 October 24, 2018
NCT03345212 Completed N/A A Randomized Controlled Multicenter Trial of Exercise Training in Pulmonary Hypertension in European Countries February 2016 December 2019
NCT02129309 Completed N/A Haemodynamic Effects of Apelin Agonists and Antagonists in Man in COPD With Raised Pulmonary Artery Pressures June 2014 December 2014
NCT02133352 Completed Phase 4 Study of Ranolazine in the Treatment of Pulmonary Hypertension Associated With Diastolic Left Ventricular Dysfunction July 2011 May 2014
NCT03310346 Completed Registry of Preterm Newborns With Severe Pulmonary Hypertension August 1, 2017 July 2, 2022
NCT02216279 Completed Phase 2 Phase-II Study of the Use of PulmoBind for Molecular Imaging of Pulmonary Hypertension September 2014 September 2015
NCT02220335 Completed N/A Pulmonary Arterial Denervation in Patients With Pulmonary Hypertension Associated With the Left Heart Failure August 8, 2014 December 30, 2018
NCT03310229 Completed Pulmonary Hypertension in Haemodialysis Patients :Frequency and Risk Factors December 1, 2018 December 2, 2019
NCT02223559 Completed Non-invasive Assessment of Pulmonary Artery Pressure August 2014 June 2017
NCT03270332 Completed Phase 2 Effect of Inhaled Albuterol in Pulmonary Hypertension October 5, 2017 July 2, 2020
NCT03198910 Completed Retrospective Data Analysis of Data From the Zurich PH Registry June 2, 2017 December 31, 2018
NCT03195959 Completed Effect of Normobaric Hypoxia and Hyperoxia in Patients With Pulmonary Hypertension June 22, 2017 May 1, 2022
NCT02252705 Completed Mexican Registry of Pulmonary Hypertension July 2014 April 2018
NCT02265887 Completed The Pan African Pulmonary Hypertension Cohort Study June 2012 June 2015
NCT02267655 Completed Phase 1 3 Part Study to Assess Inhaled Nitric Oxide on Functional Pulmonary Imaging in Subj. Pulmonary Hypertension Associated w/ COPD and IPF May 2015 June 28, 2017
NCT02275793 Completed The Regulation of Pulmonary Vascular Resistance in Patients With Heart Failure September 2011 September 2015
NCT03194438 Completed N/A Urban Zen Integrative Therapy for Persons With Pulmonary Hypertension June 19, 2017 June 5, 2018
NCT02290613 Completed Phase 2 Early Treatment of Borderline Pulmonary Arterial Hypertension Associated With Systemic Sclerosis (SSc-APAH) July 1, 2014 December 31, 2017
NCT03155373 Completed The Right Ventricular Pulmonary Circulation Continuum in Mitral Valve Disease Study February 15, 2017 March 1, 2019
NCT02331225 Completed Endothelial Microparticles in Systemic Sclerosis Pulmonary Hypertension December 2014 October 2016
NCT03154034 Completed Cardiopulmonary Exercise Testing in Severe Mitral Regurgitation August 13, 2014 August 31, 2018
NCT03146702 Completed Turkish Translation of The Emphasis-10 Questionnaire October 2016 September 2017
NCT03134898 Completed Longitudinal Study to Identify Predictive Factors of Post-thrombotic Pulmonary Hypertension November 24, 2013 July 30, 2019
NCT02377934 Completed Evaluation of Radiation Induced Pulmonary Hypertension Using MRI in Stage III NSCLC Patients Treated With Chemoradiotherapy. A Pilot Study September 2012 August 2015
NCT02378649 Completed Phase 4 PDEI Following Mitral Valve Surgery in Patients With Pulmonary Hypertension March 2015 June 2018
NCT02429284 Completed U.S. CTEPH Registry April 2015 November 2019
NCT03133169 Completed Erythrocyte Glutamine Level Relation to Pulmonary Hypertension Risk in Beta Thalassemia Major Children June 1, 2017 August 26, 2019
NCT02485977 Completed Cardiac MRI in Pulmonary Hypertension July 2015 June 2017
NCT02554903 Completed Phase 2 Clinical Study to Assess the Efficacy and Safety of Macitentan in Patients With Pulmonary Hypertension After Left Ventricular Assist Device Implantation March 28, 2016 March 13, 2020
NCT03122730 Completed Phase 2 VentaProst Versus Conventionally-Administered Aerosolized Epoprostenol in Patients Undergoing Cardiac Surgery With CPB August 23, 2017 May 30, 2019
NCT03077139 Completed N/A Cardiac Resynchronization Therapy in Pulmonary Hypertension November 29, 2012 March 23, 2017
NCT02580903 Completed Pulmonary Hypertension in Patients With Myeloproliferative Neoplasms February 2015 February 2020
NCT02587325 Completed Phase 1 Phase 1/1b Study With Nab-sirolimus for Patients With Severe Pulmonary Arterial Hypertension April 1, 2017 September 16, 2022
NCT02594917 Completed Genetic and Environmental Determinants That Control Metabolism in Pulmonary Hypertension October 2015 September 1, 2023
NCT02595541 Completed Phase 1/Phase 2 Oral Sildenafil and Intravenous Milrinone on Postoperative Pulmonary Hypertension June 2015 October 2015
NCT03045614 Completed Kidney Disease and Pulmonary Hypertension February 1, 2017 August 28, 2018
NCT02630316 Completed Phase 2/Phase 3 Safety and Efficacy of Inhaled Treprostinil in Adult PH With ILD Including CPFE February 3, 2017 December 26, 2019
NCT03039972 Completed Changes in Renal Function and Body Composition in Pulmonary Hypertension January 25, 2017 July 9, 2020
NCT03039959 Completed Predictive Value of Renal Venous Flow Profiles for Adverse Outcomes in Right Heart Failure November 2016 September 30, 2019
NCT02712294 Completed N/A Impact of NMES on Spirometry Values, Functional Capacity and Quality of Life in Patients With Pulmonary Hypertension June 2014 December 2016
NCT02729844 Completed Neolifes Heart - Pulmonary Hypertension in Preterm Children June 1, 2016 August 25, 2021
NCT02742909 Completed Phase 4 Acute Effects of rhBNP in Patients With PH Associated With Acute Exacerbation of Chronic Pulmonary Disease December 2015 December 2018
NCT02743091 Completed Idiopathic Pre-capillary Pulmonary Hypertension in ESKD Patients January 2001 December 2015
NCT03030807 Completed Pulmonary Hypertension in Hypersensitivity Pneumonitis October 2016 October 31, 2020
NCT02752269 Completed Early Detection of Pulmonary- and Pulmonary Vascular Disease in Sjögren Syndrome October 2014 June 30, 2019
NCT02999438 Completed Frailty in Children With Cardiac Disease November 2016 October 2022
NCT02951104 Completed N/A Noninvasive Cardiac Output Monitoring in Pulmonary Hypertension November 2016 October 2021
NCT02892981 Completed N/A Dead Space Evaluation in Pulmonary Hypertension January 2015 April 2016
NCT02886793 Completed Phase 1/Phase 2 Cell Proliferation in Pulmonary Hypertension. FDG-PET Comparison Between Patients and Healthy Subjects June 2016 August 2018
NCT02885116 Completed N/A Effect of Nasal Highflow on Right Heart Function January 2016 February 2018
NCT02873039 Completed Correlation Between Estimated Right Atrial Pressure and BNP in Pulmonary HTN (CRAB-PH) July 2016 July 2020
NCT02782026 Completed N/A Exhaled Breath Olfactory Signature of Pulmonary Arterial Hypertension March 4, 2016 September 4, 2018
NCT02790918 Completed Diagnosis of Pulmonary Hypertension Using Cardiac Magnetic Resonance Images May 2013 October 2019
NCT03683186 Enrolling by invitation Phase 3 A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension September 23, 2019 September 2024
NCT01725763 Enrolling by invitation N/A Non-contrast Enhanced Cardiac Magnetic Resonance Imaging in the Diagnosis and Classification of Pulmonary Hypertension December 2012 December 2030
NCT03149341 Enrolling by invitation MRI and Computational Simulation Cardiology Study February 2008 February 2025
NCT05550389 Enrolling by invitation Genetics of Pulmonary Hypertension June 2, 2021 March 2023
NCT06443580 Not yet recruiting N/A Interoceptive Intervention for Pulmonary Hypertension June 17, 2024 October 18, 2024
NCT04188756 Not yet recruiting N/A RV Systolic and Diastolic Function and Contractile Reserve Under Acute Exercise and in Response to Chronic Exercise-based Rehabilitation July 1, 2022 July 1, 2024
NCT05136235 Not yet recruiting N/A Pulmonary Hypertension in Extremely Preterm Infants January 2022 December 2025
NCT05655481 Not yet recruiting N/A Telerehabilitation Program Via Videoconference PAH - Randomized Clinical Trial January 15, 2023 May 10, 2025
NCT05918458 Not yet recruiting Discovering Clinical Study Experiences of Patients With Pulmonary Hypertension July 2024 July 2026
NCT05937854 Not yet recruiting Phase 2 Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH April 1, 2024 December 1, 2027
NCT05980728 Not yet recruiting Connective Tissue Disease Patients With Pulmonary Hypertension November 1, 2023 September 1, 2030
NCT05996562 Not yet recruiting N/A Study for Evaluation of Safety and Efficacy of PADN to Treat Combined Post- and Pre- Capillary Pulmonary Hypertension Associated With Chronic Heart Failure December 2023 December 2024
NCT06031311 Not yet recruiting Pulmonaryhypertension in Copd at Different Levels of Smoking October 1, 2023 December 1, 2024
NCT06174207 Not yet recruiting N/A Hyperoxia During Pulmonary Rehabilitation in Chronic Lung Disease - Does it Matter? January 1, 2024 April 30, 2025
NCT06249633 Not yet recruiting Early Phase 1 Inhaled Nitric Oxide for ARDS-related Pulmonary Hypertension February 2024 February 2026
NCT06254092 Not yet recruiting N/A Effect of Tourniquet Binding of Cervical on the Blood Volume of Amniotic Fluid in Cesarean Section January 31, 2024 August 1, 2024
NCT06299436 Not yet recruiting Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure September 1, 2024 March 31, 2029
NCT06327373 Not yet recruiting Phase 1/Phase 2 A Feasibility Study of Supplemental Oxygen to Improve Pulmonary Hypertension in People With Intradialytic Hypoxemia July 1, 2024 June 30, 2025
NCT06331208 Not yet recruiting Mechanisms of Pulmonary Vascular Dysfunction in Heart Failure April 1, 2024 December 30, 2026
NCT06336798 Not yet recruiting Phase 2 Bioenergetic Effect of Pioglitazone in CLD-PH May 2024 August 2028
NCT06351345 Not yet recruiting Phase 2 129 Xenon Imaging in Patients Treated With Sotatercept June 1, 2024 August 1, 2025
NCT06362382 Not yet recruiting N/A Mobile Internet-based Remote Home Rehabilitation Improves Prognostic Function and Life Quality in Pulmonary Hypertension April 22, 2024 May 1, 2026
NCT06373289 Not yet recruiting N/A Target Oxygen Ranges in Infants With Pulmonary Hypertension July 1, 2025 July 1, 2030
NCT06386185 Not yet recruiting Developing the Probability Algorithm for Pulmonary Hypertension Echocardiography July 1, 2024 November 1, 2026
NCT06388421 Not yet recruiting DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD) August 1, 2024 November 30, 2030
NCT06416163 Not yet recruiting FIBRotic Interstitial Lung Disease With Nocturnal hypOXaemia and EXercise Induced desaTuRAtion July 1, 2024 July 1, 2029
NCT00491309 Recruiting N/A Exercise and Respiratory Therapy in Patients With Rheumatoid Arthritis / Collagenosis and Pulmonary Hypertension July 2011 December 2023
NCT03169010 Recruiting Registration Study for Rare Type of Pulmonary Hypertension May 6, 2017 December 31, 2040
NCT05935865 Recruiting Monitoring of the Influence of Approved PH-therapies RV-PA Coupling February 13, 2023 February 13, 2026
NCT02061787 Recruiting the Application of Cardiopulmonary Exercise Testing in Assessment Outcome of Patients With Pulmonary Hypertension September 2010 September 8, 2030
NCT05329714 Recruiting PVRI GoDeep Global Deep Phenotyping Meta-Registry for Pulmonary Hypertension January 30, 2020 January 30, 2055
NCT04071327 Recruiting Pulmonary Hypertension Association Registry October 2015 October 2025
NCT04078243 Recruiting Feasibility of Novel Clinical Trial Infrastructure, Design and Technology for Early Phase Studies in Patients With Pulmonary Hypertension (FIT-PH) January 21, 2020 September 6, 2028
NCT05299463 Recruiting N/A Remote Exercise Testing in Patients With Pulmonary Hypertension June 9, 2021 August 1, 2024
NCT06038149 Recruiting Improving Pulmonary Hypertension Screening by Echocardiography November 11, 2023 February 2025
NCT05201144 Recruiting Phase 2 A Trial of Phosphodiesterase-5 Inhibitor in Neonatal Congenital Diaphragmatic Hernia (TOP-CDH) September 15, 2022 September 2025
NCT04101630 Recruiting Activity Monitoring in Pulmonary Hypertension October 24, 2019 June 2026
NCT04145024 Recruiting Giessen Pulmonary Hypertension Registry and Biobank July 1993 January 15, 2036
NCT05133713 Recruiting Ventilation and Perfusion Scan in Pulmonary Embolism Following Catheter Directed Thrombectomy Versus Anticoagulation Alone April 1, 2022 January 1, 2024
NCT04993612 Recruiting Postcapillary Blood Gas Analysis in Wedge Position (Wedge-BGA) June 25, 2021 June 30, 2024
NCT04224012 Recruiting N/A Effect of Exercise and Respiratory Therapy on Right Ventricular Function in Severe Pulmonary Hypertension August 2015 August 2024
NCT04224025 Recruiting N/A Training Single Arm November 3, 2015 December 2025
NCT04231084 Recruiting Phase 4 Comparison of Vasodilator Response of Inhaled Epoprostenol and Inhaled Nitric Oxide January 15, 2021 December 2024
NCT04991454 Recruiting Phase 2 Xenon MRI Pulm Hypertension September 1, 2021 August 30, 2026
NCT04947384 Recruiting Pulmonary Vascular Hemodynamics Before and After Mitral Valve Procedures December 21, 2021 January 20, 2025
NCT04909008 Recruiting N/A Exercise Training to Improve Cardiopulmonary Hemodynamics in Heart Failure Patients January 1, 2024 August 2026
NCT06409624 Recruiting Association Between Biomarkers and eGFR Decline in Pulmonary Hypertension May 2024 July 2026
NCT04901884 Recruiting N/A PET/MR Pre- and Post Radiotherapy for Cardiopulmonary Dysfunction Evaluation June 1, 2021 June 2024
NCT04373902 Recruiting N/A Physiological-based Cord Clamping in Congenital Diaphragmatic Hernia May 11, 2020 July 1, 2024
NCT04842591 Recruiting Characteristics of Pulmonary Vascular Changes in Patients With Kidney Transplantation December 23, 2020 December 31, 2025
NCT04808596 Recruiting Pulmonary Hypertension Biorepository and Registry August 10, 2020 July 31, 2026
NCT05935605 Recruiting Pulmonary Hypertension in Left Heart Disease July 20, 2023 May 2028
NCT05903001 Recruiting Diaphragmatic Function as a Biomarker July 1, 2023 June 30, 2025
NCT04756076 Recruiting Study Roles of Heavy Metals and Essential Metal Dyshomeostasis in Pulmonary Arterial Hypertension Patients December 2, 2020 December 31, 2024
NCT04654767 Recruiting Inflammatory Profiling in Chronic Lung Disease December 1, 2021 June 30, 2025
NCT04654650 Recruiting Prospective Registry and Biobank for Long-term Observational Studies in Adult Patients With Pulmonary Hypertension January 26, 2021 January 25, 2041
NCT04554160 Recruiting Arrhythmias in Pulmonary Hypertension Assessed by Continuous Long-term Cardiac Monitoring September 24, 2018 November 1, 2024
NCT04555161 Recruiting N/A Treatment of Pulmonary Arterial Hypertension Using the Aria CV Pulmonary Hypertension System March 15, 2021 October 2026
NCT04636892 Recruiting N/A Evaluating Infrasonic Hemodynography January 4, 2021 December 1, 2025
NCT05901168 Recruiting N/A Acute Responses of Active Video Games and Traditional Exercise Program in in Patients With Pulmonary Hypertension August 1, 2023 March 2024
NCT04624490 Recruiting Phase 1 Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease November 2, 2020 October 26, 2026
NCT05896579 Recruiting N/A Identifying Right Ventricular Dysfunction in COPD Through Right Heart Catheterization, Imaging and Exercise August 22, 2023 June 2028
NCT05873387 Recruiting Development of an Algorithm to Detect Pulmonary Hypertension Using an Electronic Stethoscope July 12, 2023 December 2025
NCT06405126 Recruiting Validation of a Machine Learning Predictive Model to Distinguish Post-capillary Pulmonary Hypertension February 21, 2024 February 2026
NCT06145880 Recruiting ADOPT: Improving Diagnosis of Pulmonary Hypertension With AI and Echo December 1, 2023 December 1, 2025
NCT05856461 Recruiting N/A Pulmonary Artery Denervation in Patients With Atrial Fibrillation and Group 2 of Pulmonary Hypertension May 22, 2023 February 22, 2025
NCT05844462 Recruiting Phase 3 Tadalafil for Severe Pulmonary Hypertension Due to Chronic Obstructive Pulmonary Disease February 1, 2024 September 2026
NCT05843461 Recruiting PIMR and Pulmonary Vascular Disease January 10, 2023 October 31, 2024
NCT05827302 Recruiting N/A Integrating ePReBMs From Phoenix in Respiratory Diseases October 11, 2023 April 2028
NCT03576885 Recruiting Phase 1/Phase 2 Inhaled Nitric Oxide for Pulmonary Hypertension and Bronchopulmonary Dysplasia July 15, 2019 December 1, 2024
NCT05983250 Recruiting Phase 3 LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF January 10, 2024 July 2027
NCT02748798 Recruiting Early Phase 1 Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders November 10, 2020 December 22, 2023
NCT05824923 Recruiting Phase 3 A Trial to Evaluate the Safety and Efficacy of Pulmonary Artery Denervation for the Treatment of Pulmonary Hypertension Associated With Left Heart Failure August 14, 2023 February 2027
NCT05812976 Recruiting Novel Index (PIMR) in PAH February 1, 2023 February 1, 2025
NCT06250374 Recruiting N/A Assessment of the Cerebral Perfusion During the Period of Deep Hypothermia at 18°C in Patient Undergoing Pulmonary Endarterectomy Surgery. August 24, 2023 May 24, 2025
NCT01730092 Recruiting Natural History Study of Biomarkers in Pulmonary Arterial Hypertension July 15, 2013
NCT05798923 Recruiting Phase 2 A Phase 2a Study of LAM-001 for the Treatment of Pulmonary Hypertension April 3, 2023 December 31, 2025
NCT05785195 Recruiting N/A A Mechanistic Study of Inhaled Nitric Oxide in COPD March 14, 2023 March 31, 2024
NCT03626688 Recruiting Phase 3 A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients August 30, 2018 December 2024
NCT03629340 Recruiting Phase 2 Metformin for Pulmonary Hypertension HFpEF February 26, 2019 September 2024
NCT03630211 Recruiting Phase 2 Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis July 31, 2018 August 1, 2025
NCT01607502 Recruiting Database for Clinical and Anamnestic Data in Pulmonary Hypertension July 2010 July 2024
NCT01571700 Recruiting Investigation of Dysynchrony in Patients With Pulmonary Hypertension September 2006 December 2025
NCT05776225 Recruiting Pulmonary Hypertension Screening in Patients With Interstitial Lung Disease for Earlier Detection August 11, 2023 February 1, 2025
NCT06135909 Recruiting CHASE Registry of Patients With Pulmonary Hypertension Receiving Targeted Therapy January 1, 2020 December 31, 2027
NCT05746039 Recruiting Phase 1/Phase 2 Feasibility of Semaglutide in Advanced Lung Disease January 29, 2024 June 28, 2024
NCT05731466 Recruiting N/A Exercise Right Ventricular Coupling in HFpEF October 13, 2021 December 31, 2025
NCT03269630 Recruiting New Orleans Pulmonary Hypertension Biobank December 29, 2017 October 2027
NCT05726669 Recruiting N/A Self-help Booklets for Depression in Adults With Pulmonary Hypertension. June 8, 2023 August 2024
NCT06129240 Recruiting An Open-Label ProSpective MultiCENTer Study to Evaluate Safety and Tolerability of Dry Powder Inhaled Treprostinil in PH December 28, 2023 October 31, 2026
NCT05699681 Recruiting Correlation of Right Atrial Strain With Pulmonary Hypertension, Right Ventricular Function And Outcome In Pediatric Patients January 1, 2021 February 15, 2023
NCT01387035 Recruiting Early Diagnosis of Pulmonary Hypertension in Patients With Inflammatory Rheumatic Connective Tissue Diseases January 2010 December 2025
NCT05958901 Recruiting Pulmonary Hypertension Observational Study July 12, 2023 December 30, 2027
NCT06079151 Recruiting N/A Hemodynamic Effect of Nasal High-flow in Patients Suspected or Followed for a Precapillary Pulmonary Hypertension February 13, 2024 February 12, 2026
NCT05699486 Recruiting Phase 2 A Study to Evaluate the Efficacy, Safety and Tolerability of PDNO Infusion in Patients With Pulmonary Hypertension After Cardiopulmonary Bypass Surgery October 23, 2022 December 31, 2023
NCT05679206 Recruiting Antiphospholipid Syndrome and Postpartum Pulmonary Artery Pressure December 20, 2022 December 31, 2028
NCT05665218 Recruiting Comparison of Different Cardiac Output Measurement Methods in Patients Undergoing Right Heart Catheterization January 1, 2022 December 31, 2024
NCT05649722 Recruiting Phase 2/Phase 3 An Extension Study of Treprostinil Palmitil Inhalation Powder (TPIP) for Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD) May 11, 2023 May 31, 2024
NCT05636397 Recruiting N/A Safety and PK-PD Study of Oral L-CIT in Preterm Infants With BPD±PH and NEC November 1, 2023 March 2028
NCT06050525 Recruiting Incidence of Acute Kidney Injury and Risk Factors in Newborns With Congenital Diaphragmatic Hernia February 1, 2023 October 31, 2024
NCT05612035 Recruiting Phase 2 MK-5475-013 INSIGNIA-PH-COPD: A Study of the Efficacy and Safety of MK-5475 (an Inhaled sGC Stimulator) in Adults With PH-COPD March 16, 2023 March 23, 2028
NCT06365372 Recruiting Circulating MrgD in Pulmonary Hypertension April 10, 2024 June 1, 2024
NCT05610631 Recruiting Pulmonary Hypertension Registry Switzerland June 1, 2017 December 2027
NCT05595200 Recruiting Prevalence, Phenotypes, Predictors and Prognostic Implication of Obstructive Sleep Apnea in Pulmonary Hypertension May 1, 2020 December 31, 2025
NCT03835676 Recruiting Phase 4 Effects of Treprostinil on Right Ventricular Structure and Function in Patients With Pulmonary Arterial Hypertension May 1, 2019 December 1, 2025
NCT05566002 Recruiting Artificial Intelligence-assisted Evaluation of Pulmonary HYpertension June 1, 2022 December 31, 2024
NCT05553015 Recruiting A Real-World Registry Investigating TReprostInil sodiUM in Pulmonary Hypertension (Re-TRIUMPH) December 24, 2020 December 31, 2025
NCT05523557 Recruiting N/A Urban-training Intervention in Pulmonary Hypertension (UTHAP) February 1, 2023 December 31, 2025
NCT05442671 Recruiting N/A iTONE Trial (exercIse Training in pulmONary hypertEnsion) Exercise Program for Pediatric PH April 3, 2024 December 31, 2026
NCT05372263 Recruiting Safety Surveillance of Targeted Drugs for Pulmonary Hypertension Using a Computerized Follow-up System: a Nationwide Cohort Study August 26, 2021 December 31, 2025
NCT03022851 Recruiting N/A The Prophet Trial -Pilot Study to Assess Safety and Efficacy of a Novel Atrial Flow Regulator (AFR) in Patients With Pulmonary Hypertension July 19, 2017 December 2023
NCT00477724 Recruiting N/A Latent Pulmonary Hypertension (PH) in Chronic Thromboembolic Pulmonary Hypertension (CTEPH )After Endarterectomy and Influence of Exercise and Respiratory Therapy June 2007 December 2023
NCT04019600 Suspended Screening of Pulmonary Hypertension in Methamphetamine Abusers December 23, 2019 December 22, 2022
NCT03854071 Suspended N/A Development of Novel Physiological CMR Methods in Health and Disease July 30, 2018 May 1, 2026
NCT00145938 Terminated Phase 2 Sildenafil and Pulmonary Artery Pressure September 2003 September 2006
NCT03135860 Terminated Early Phase 1 Effect iNO on Functional Respiratory Imaging in Subjects With WHO Group 3 Pulmonary Hypertension With COPD on Oxygen October 2016 August 21, 2017
NCT02324868 Terminated N/A Impact of Availability of Showerpatch for Patients With Intravenous Catheters January 2016 March 2016
NCT02246348 Terminated N/A Evaluating Lung Doppler Signals in Patients With Systemic Sclerosis (SSc) September 2014 December 2015
NCT02243111 Terminated N/A Detecting Pulmonary Arterial Hypertension (PAH) in Patients With Systemic Sclerosis (SSc) by Ultrasound September 2014 December 2015
NCT03267108 Terminated Phase 3 A Study to Assess Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Fibrosis at Risk for Pulmonary Hypertension December 14, 2020 June 30, 2023
NCT02237378 Terminated N/A A Pilot Study Evaluating Heart and Lung Metabolism in Pulmonary Hypertension Associated With Left Heart Disease December 2014 August 2018
NCT02220634 Terminated N/A Regadenoson for Acute Vasoreactivity Testing in Pulmonary Hypertension August 2014 May 25, 2017
NCT02170519 Terminated Phase 4 Inhaled Aerosolized Prostacyclin for Pulmonary Hypertension Requiring Inhaled Nitric Oxide September 2006 January 2009
NCT02120339 Terminated Phase 1 Carvedilol PAH A Pilot Study of Efficacy and Safety May 2014 June 2016
NCT02078557 Terminated Phase 1 A Multiple Dose Titration Study of MK-8892 in Participants With Pulmonary Hypertension and Left Heart Disease (MK-8892-007) May 9, 2014 September 10, 2014
NCT02053246 Terminated Phase 4 Improving Treatment Personalization of Pulmonary Hypertension Associated With Diastolic Heart Failure January 2014 March 2021
NCT02050230 Terminated Phase 4 Hemodynamic Effects of Stored Blood Transfusion in Intensive Care Patients January 2014 June 2016
NCT03496623 Terminated Phase 3 A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD) May 8, 2018 October 13, 2022
NCT03542812 Terminated Early Phase 1 L-citrulline and Pulmonary Hypertension Associated With Bronchopulmonary Dysplasia July 30, 2019 August 31, 2022
NCT01913457 Terminated Measurements and Characterization of Doppler Signals From the Right Chest in Pediatric and Adult Patients July 2013 July 1, 2021
NCT01910389 Terminated Phase 3 Phosphodiesterase Type 5 Inhibition With Tadalafil Changes Outcomes in Heart Failure November 2013 February 2014
NCT01839786 Terminated Evaluation of Lung Doppler Signals in Pulmonary Hypertension May 2013 February 2017
NCT01479010 Terminated Phase 1/Phase 2 Pilot Study of the Safety and Efficacy of Anakinra (Recombinant Human Interleukin-1 Receptor Antagonist) in Pulmonary Hypertension November 2011 November 2013
NCT01467076 Terminated Phase 2 Inhaled Prostaglandin E1 (IPGE1) for Hypoxemic Respiratory Failure (NHRF) November 2011 June 2012
NCT01437878 Terminated Phase 2 Effects of Ventavis in Patients With Pulmonary Hypertension (PH) Secondary to Chronic Obstructive Pulmonary Disease (COPD) March 2012 November 2012
NCT03673774 Terminated N/A Impedancemetry in Patients Monitored for Pulmonary Hypertension August 23, 2017 January 1, 2021
NCT01370096 Terminated Phase 2 Vasopressin and Inhaled Prostacyclin in Pediatric Pulmonary Hypertension February 2012 September 2016
NCT01241942 Terminated N/A Phase 2 Study of Ex-vivo Perfusion and Ventilation of Lungs to Assess Transplant Suitability December 2010 March 2013
NCT03794583 Terminated Phase 3 Inhaled Treprostinil in Participants With Pulmonary Hypertension Due to Chronic Obstructive Pulmonary Disease (PH-COPD) December 21, 2018 November 29, 2022
NCT03935178 Terminated Evaluating Right Ventricular (RV) Size and Function Using the Upper Valley RV Algorithm and Novel Imaging Modalities August 5, 2019 January 30, 2022
NCT01072643 Terminated Phase 2/Phase 3 Sedation With Dexmedetomidine During Cardiac Catheterization March 2010 April 2013
NCT04008550 Terminated N/A Prognostic Impact of the Evolution of PAH 3 Months After TAVI (HTP-TAVI) March 6, 2019 March 5, 2020
NCT01036802 Terminated Phase 2 Anticoagulation For Pulmonary Hypertension in Sickle Cell Disease December 2009 September 2012
NCT04084678 Terminated Phase 3 A Study of Ralinepag to Evaluate Effects on Exercise Capacity by CPET in Subjects With WHO Group 1 PH January 20, 2021 April 12, 2023
NCT04329312 Terminated Differential Diagnosis of Pulmonary Hypertension With Automated Image Analysis June 15, 2020 October 1, 2021
NCT00926627 Terminated Phase 2 Safety and Efficacy Study of Bosentan in Progressive Pulmonary Sarcoidosis April 2009 March 2010
NCT00879229 Terminated Phase 3 ARTEMIS-PH - Study of Ambrisentan in Subjects With Pulmonary Hypertension Associated With Idiopathic Pulmonary Fibrosis July 2009 February 2011
NCT00840463 Terminated Phase 4 Safety and Efficacy Trial to Treat Diastolic Heart Failure Using Ambrisentan January 2009 January 2014
NCT00796666 Terminated Phase 3 Study Looking at Combination Therapy (Sitaxsentan+Sildenafil) Vs. Monotherapy (Sitaxsentan Alone) SR-PAAS -Sitaxsentan Efficacy And Safety Trial With A Randomized Prospective Assessment Of Adding Sildenafil May 2009 March 2011
NCT00796510 Terminated Phase 3 Study Providing Monotherapy (Sitaxsentan) And Combination Therapy (Sitaxsentan+Sildenafil) To Subjects With Pulmonary Arterial Hypertension (PAH) To Assess Long-Term Safety July 2010 January 2011
NCT00795639 Terminated Phase 3 Sitaxsentan Efficacy And Safety Trial With A Randomized Prospective Assessment Of Adding Sildenafil (SR-PAAS) December 2008 March 2011
NCT00718185 Terminated Pharmacokinetics and Pharmacdynamics of Sildenafil May 2008 February 2010
NCT00706082 Terminated Early, Simple and Reliable Detection of Pulmonary Arterial Hypertension (PAH) in Systemic Sclerosis (SSc) October 2008 March 2012
NCT00703339 Terminated Phase 2 Effects of Inhaled Treprostinil Sodium for the Treatment of Pulmonary Hypertension Associated With Idiopathic Pulmonary Fibrosis June 2008 December 2009
NCT00679068 Terminated Phase 4 Effects of Bosentan on Respiratory Mechanics May 2008 June 2013
NCT00677872 Terminated Phase 2 An Open-Label Study to Evaluate the Safety and Efficacy of PRX-08066 in Patients With Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease May 2008
NCT03089164 Terminated Postural Changes During Right Heart Catheterization May 1, 2017 January 29, 2018
NCT00583115 Terminated Phase 2 Safety Study of Gleevec® in Children With Pulmonary Hypertension October 2007 December 2013
NCT00492531 Terminated Phase 2 Sildenafil Therapy for Pulmonary Hypertension and Sickle Cell Disease June 2007 October 2009
NCT05267418 Terminated N/A Effects of Automated Oxygen Titration Alone or With High Flow Nasal Therapy on Dyspnea and Exercise Tolerance February 26, 2019 March 30, 2021
NCT00467896 Terminated Phase 2 The "Power 15 Study": Safety Study of Inhalation of Ventavis With the Power Disc-15 Setting September 2006 June 2011
NCT00409526 Terminated Phase 4 Inhaled Iloprost for the Treatment of Persistent Pulmonary Hypertension in the Term and Near Term Infants. December 2006 December 2007
NCT00377455 Terminated Phase 2 Placebo Controlled Trial of Bosentan in Scleroderma Patients September 2006 March 2010
NCT00360087 Terminated Phase 3 A Study of Patients Having Pulmonary Hypertension Associated With Sickle Cell Disease and Completing an ASSET Study March 2006 December 2007
NCT00350844 Terminated Phase 1/Phase 2 Hydroxyurea for Children and Young Adults With Sickle Cell Disease and Pulmonary Hypertension July 2006 June 2008
NCT00313196 Terminated Phase 3 Efficacy and Safety of Bosentan in Sickle Cell Disease (SCD) Patients Diagnosed With Pulmonary Hypertension (PH) April 2006 August 2007
NCT00075179 Terminated Phase 4 Natrecor in Pulmonary Hypertension December 31, 2003 March 28, 2006
NCT00310830 Terminated Phase 3 Efficacy and Safety of Bosentan in Sickle Cell Disease (SCD) Patients With Pulmonary Arterial Hypertension (PAH) March 2006 August 2007
NCT00302211 Terminated Phase 3 The "VISION" Trial: Ventavis Inhalation With Sildenafil to Improve and Optimize Pulmonary Arterial Hypertension February 1, 2006 July 1, 2008
NCT00041574 Terminated Phase 2 Hospital-Based Program for Treatment of Severe Cardiopulmonary Disease With Inhaled Nitric Oxide April 2002 December 2005
NCT03037580 Terminated Phase 3 Oral Treprostinil in Subjects With Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction August 15, 2017 December 3, 2019
NCT02651272 Terminated Phase 2 Macitentan in Pulmonary Hypertension of Sickle Cell Disease July 2015 December 18, 2019
NCT02633293 Terminated Phase 2/Phase 3 An Open Label Extension Study to Evaluate Inhaled Treprostinil in Adult PH With ILD Including CPFE September 15, 2016 August 1, 2021
NCT03044314 Terminated Phase 4 Outpatient Vasodilator Assessment Using Iloprost in Pulmonary Hypertension July 21, 2017 May 19, 2020
NCT03068130 Terminated Phase 3 Extended Access Program to Assess Long-term Safety of Bardoxolone Methyl in Patients With Pulmonary Hypertension RANGER April 18, 2017 September 30, 2020
NCT02752399 Unknown status Six Minutes Walk Test and Shuttle Walk Test in Eisenmenger Syndrome April 2016 June 2017
NCT02778802 Unknown status Pulmonary Hemodynamics in Patients With Severe Emphysema Pre and Post BLVR June 2016 May 2017
NCT00637065 Unknown status Phase 4 Bosentan in Pulmonary Hypertension in Interstitial Lung Disease Treatment Study April 2008 August 2010
NCT01972009 Unknown status Wave Intensity Analysis in the Pulmonary Artery October 2013 September 2015
NCT03476629 Unknown status N/A Effects of Different Types of Physical Training in Patients With Pulmonary Arterial Hypertension. January 10, 2016 December 10, 2020
NCT03464591 Unknown status Cardiac Speckle Tracking Myocardial Strain Balance November 1, 2017 December 30, 2018
NCT03460470 Unknown status Phase 3 Sildenafil in US Heart Failure Patients (SilHF-US) February 14, 2018 December 2018
NCT03459716 Unknown status Endothelial Biomarkers of Systemic Sclerosis-associated Pulmonary Hypertension June 1, 2018 December 1, 2021
NCT02571231 Unknown status N/A High Flow Ventilation With Volume Guarantee November 2015 July 2016
NCT01979822 Unknown status LenusPro Safety (LPS) Study in Patients With PH February 2013 September 2015
NCT03377673 Unknown status Right Ventricular and Pulmonary Artery Evaluation by CMR January 1, 2012 November 1, 2018
NCT03217240 Unknown status Integrated Computational modelIng of Right Heart Mechanics and Blood Flow Dynamics in Congenital Heart Disease June 5, 2017 August 30, 2019
NCT03197792 Unknown status N/A Perioperative Portal Vein Pulsatility as a Postoperative Prognostic Indicator in Pulmonary Endarterectomy May 26, 2017 May 24, 2019
NCT00173537 Unknown status N/A Genetic Research of Bone Morphogenetic Protein Receptor-II Gene in Taiwanese Patient With Primary Pulmonary Hypertension July 2005 December 2013
NCT03185572 Unknown status Registry for Chronic Obstructive Pulmonary Disease With Pulmonary Hypertension in China June 15, 2017 December 31, 2020
NCT04594629 Unknown status Phase 1 PGI2 Versus Nitroglycerine for Management of Pulmonary Hypertension After Valve Surgeries November 2020 June 2021
NCT00830726 Unknown status Water- and Salt-homeostasis in Healthy Humans, and in Patients With Heart- or Lung Disease February 2009 February 2012
NCT04589390 Unknown status Phase 2 Selexipag for the Treatment of Schistosomiasis-Associated Pulmonary Arterial Hypertension October 15, 2020 March 31, 2022
NCT03185364 Unknown status N/A The Safety and Efficiency of Sildenafil in the Treatment of Severe Post-capillary Pulmonary Hypertension Caused by COPD June 15, 2017 December 31, 2020
NCT04499196 Unknown status Glucocorticoids and Pulmonary Hypertension July 29, 2020 July 29, 2022
NCT04683822 Unknown status N/A Telerehabilitation in Patients With Pulmonary Hypertension January 2021 June 2021
NCT04729777 Unknown status Assessment of Cardiac Function Using Combined Cardiovascular Magnetic Resonance and Cardiopulmonary Exercise Testing (CMR-CPET) March 1, 2019 October 1, 2021
NCT02345616 Unknown status Phase 2 Role of the Nitric Oxide (NO) in Pre-oxygenation Before Anesthetic Induction in Patients With a Pulmonary Hypertension in Cardiac Surgery. Pilot Study of Feasibility February 2015 December 2019
NCT04450862 Unknown status N/A Anxiety Self-management Intervention for Pulmonary Hypertension August 5, 2020 August 30, 2021
NCT02368171 Unknown status Role of Heme-oxygenase (HO) and Nitric Oxide (NO) Pathway in Patients With Obstructive Sleep Apnea (OSA) and Pulmonary Hypertension (PH) March 2015
NCT04378179 Unknown status Recognition of Heart Failure With Micro Electro-Mechanical Sensors (REFLECS) December 1, 2020 December 31, 2023
NCT04857450 Unknown status N/A Anesthesia for Upper Endoscopy and Colonoscopy in Cardiac Patients With Acute Anemia November 20, 2020 December 20, 2021
NCT00986869 Unknown status The Safety of Flexible Bronchoscopy in Patients With Pulmonary Hypertension September 2009 September 2012
NCT02374229 Unknown status Phase 1 Ablation of the Pulmonary Artery With High Pulmonary Hypertension During Mitral Valve Surgery February 2015 November 2016
NCT04293640 Unknown status Neural Respiratory Drive in Pulmonary Hypertension February 1, 2019 January 2021
NCT04279145 Unknown status N/A Evaluation of Echocardiographic Indices and Blood Biomarkers in Group 1 Pulmonary Hypertension March 1, 2020 April 2023
NCT04262037 Unknown status N/A A Comparative Study of Three Modes of Ventilation During CPB in Pediatrics With Pulmonary Hypertension Undergoing Congenital Heart Surgeries August 1, 2019 November 2020
NCT04197388 Unknown status N/A Inspiratory Muscle Training in Pulmonary Arterial Hypertension June 26, 2019 April 1, 2021
NCT00034307 Unknown status Phase 2/Phase 3 Safety and Efficacy of Sitaxsentan in the Treatment of Pulmonary Arterial Hypertension
NCT02777957 Unknown status Predictors of Pulmonary Hypertension in Patients With Advanced Lung Diseases December 2008 April 2023
NCT02775539 Unknown status Phase 2 Beta3 Agonist Treatment in Chronic Pulmonary Hypertension Secondary to Heart Failure June 2016 June 2019
NCT05198206 Unknown status Pregnant Women With Pulmonary Hypertension in China November 1, 2021 May 31, 2022
NCT04088279 Unknown status N/A Novel Quantitative Magnetic Resonance Imaging (MRI) Measures in the Assessment and Follow-up of Patients With Pulmonary Hypertension (PH) November 19, 2018 June 2021
NCT02774928 Unknown status Clinical Profile of Patients With Pulmonary Hypertension Due to Lung Diseases ( Single Center Experience) June 2016 May 2017
NCT02894970 Unknown status A New Device for Measuring of Lung Photoplethysmography and Pulmonic Arterial Saturation October 2016 July 2017
NCT04083729 Unknown status N/A Persistent Pulmonary Hypertension After Percutaneous Mitral Commissurotomy September 2019 October 2021
NCT04055415 Unknown status Phase 1/Phase 2 Clinical Study of Adipose Derived Mesenchymal Stem Cells for Treatment of Pulmonary Arterial Hypertension August 1, 2019 February 1, 2021
NCT05343091 Unknown status Prognostic Value of the Right Ventricular Function by Portable Ultrasound in Patients With Pulmonary Hypertension. March 1, 2021 January 31, 2023
NCT03955016 Unknown status N/A Rehabilitation for Patients With Pulmonary Hypertension November 13, 2018 November 1, 2020
NCT01091012 Unknown status Phase 3 Effectiveness of the Vasodilator Test With Revatio, Made in Patients With Acute Pulmonary Hypertension September 2011 February 2013
NCT02768259 Unknown status Prevalence of Pulmonary Arterial Hypertension in Patients With Connective Tissue Diseases in Egyptian Patients June 2016 May 2017
NCT01112150 Unknown status N/A Effect of Normatec Pump for Relief of Leg Edema April 2010 July 2012
NCT00439543 Unknown status Phase 2/Phase 3 Trial of Iloprost in Pulmonary Hypertension Secondary to Pulmonary Fibrosis March 2007 August 2007
NCT02791282 Unknown status Phase 3 CTEPH DIAGNOSIS Europe - MRI May 2016 June 2020
NCT03013062 Unknown status Relation Between Mean Pulmonary Artery Pressure and Pulmonary Acceleration Time and Comparison With Previous Formulae January 2017 June 2017
NCT01163422 Unknown status N/A Right Ventricular Resynchronization Therapy July 2010 July 2012
NCT01234571 Unknown status Impact of Hemo-dialysis Therapy on Blood Levels of Treprostenil in End Stage Renal Disease Patients With Pulmonary Hypertension November 2010
NCT02570737 Unknown status Latin American Pulmonary Hypertension Registry April 2014 April 2019
NCT03809156 Unknown status Phase 4 Upfront Combination Pulmonary Arterial Hypertension Therapy April 26, 2016 January 31, 2021
NCT03763045 Unknown status Phase 2/Phase 3 Sildenafil in Hemodialysis Patients With Pulmonary Hypertension December 2, 2018 February 28, 2019
NCT03726398 Unknown status Phase 2/Phase 3 CompRehensive Phenotypic Characterization of Patients With Scleroderma-Associated ILD and PH September 1, 2018 December 1, 2020
NCT03707561 Unknown status RUS-registry of PH January 2016 January 2021
NCT01410279 Unknown status N/A Inspiratory Muscle Training in Pulmonary Hypertension December 2009 December 2011
NCT01441934 Unknown status Phase 3 SPHERIC-1. Sildenafil and Pulmonary HypERtension In COPD October 2010 February 2013
NCT01467791 Unknown status Registry of Sarcoidosis Associated Pulmonary Hypertension (RESAPH) November 2011 January 2018
NCT01468571 Unknown status Phase 4 Effects of Spironolactone on Collagen Metabolism in Patients With Pulmonary Arterial Hypertension July 2011 December 2015
NCT05747508 Unknown status Phase 2 A Study to Assess Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Hypertension Associated With Pulmonary Fibrosis December 29, 2017 December 2023
NCT03051763 Unknown status The Effects of Commercial Air Travel on Patients Suffering From Pulmonary Hypertension January 19, 2017 May 19, 2022
NCT01616381 Unknown status Phase 3 Sildenafil Versus Placebo in Chronic Heart Failure March 2013 December 2019
NCT01637675 Unknown status Phase 2/Phase 3 Efficacy and Safety Study of Sodium Tanshinone IIA Sulfonate on Pulmonary Hypertension May 2013 December 2014
NCT01840748 Unknown status Development and Prevention of Pulmonary Hypertension in Systemic Sclerosis April 2013 June 2017
NCT01884974 Unknown status A Case Control Study of the Prevalence of Pulmonary Hypertension in Patients With Myeloproliferative Diseases. July 2013
NCT01913847 Unknown status Phase 3 Safety and Efficacy Study of HGP1207 in Patients With Pulmonary Hypertension September 2013 December 2018
NCT03061669 Unknown status Respiratory Monitoring During Right Heart February 26, 2017 February 2020
NCT00625079 Withdrawn Phase 4 Pulmonary Hypertension Secondary to Idiopathic Pulmonary Fibrosis And Treatment With Sildenafil February 2007 December 2009
NCT00598429 Withdrawn Phase 2 Inhaled PGE1 in Neonatal Hypoxemic Respiratory Failure May 2008 September 2008
NCT03821766 Withdrawn Haemodynamic Abnormalities Recorded With Cardiac Catheterization Along With Body's Surface Micro-accelerometers (KT-KCG) February 1, 2020 December 30, 2020
NCT04559516 Withdrawn N/A Remote Exercise Program Delivery Using a Mobile Application for Pulmonary Arterial Hypertension November 3, 2022 November 3, 2022
NCT00593905 Withdrawn Pharmacogenomics in Pulmonary Arterial Hypertension July 2005 July 2012
NCT03787082 Withdrawn Phase 1 Chlorhexidine Mouthwash and Oral Nitrate in Adults With Pulmonary Hypertension December 2022 December 2023
NCT00850369 Withdrawn Phase 2 A Pilot Study of Chronic Red Blood Cell Transfusion in Sickle Cell Disease-Associated Pulmonary Hypertension February 2005 May 2011
NCT01275690 Withdrawn Noninvasive Cardiac Output Measurements in Patients With Pulmonary Hypertension Undergoing Right Heart Catheterization With Acute Vasodilator Testing May 2010 May 2014
NCT05205265 Withdrawn N/A Rivet PVS Therapy in Group 2 PH-HFpEF May 10, 2022 December 2023
NCT02603068 Withdrawn Phase 2 Oral Treprostinil in Subjects With Pulmonary Hypertension Associated With Pulmonary Fibrosis February 2016 July 2018
NCT01275703 Withdrawn Noninvasive Cardiac Output Measurements in Patients With Pulmonary Hypertension Undergoing Exercise Testing May 2010 November 2015
NCT01950585 Withdrawn Early Phase 1 Hydroxyurea in Pulmonary Arterial Hypertension September 6, 2013 October 23, 2014
NCT01960153 Withdrawn Phase 3 Phosphodiesterase Type 5 Inhibition With Tadalafil Changes Outcomes in Heart Failure: Extent of Renal Damage October 2013 May 2018
NCT05332873 Withdrawn N/A Rivet PVS Therapy in Group 2 PH-HFpEF Canada October 2023 May 2025
NCT03997097 Withdrawn Phase 3 Efficacy of Phosphodiesterase-type 5 Inhibitors in Patients With Univentricular Congenital Heart Disease June 1, 2023 June 1, 2028
NCT02278445 Withdrawn N/A Evaluation of Pulmonary Doppler Signals in Patients With Systemic Sclerosis(SSc) November 2014 December 2015
NCT04885491 Withdrawn Phase 1/Phase 2 A Study to Evaluate the Efficacy, Safety and Tolerability of PDNO Infusion in COVID-19 Patients With Acute Pulmonary Hypertension May 7, 2021 April 30, 2023
NCT02339961 Withdrawn N/A Evaluating Pulmonary Arterial Hypertension in Patients With Systemic Sclerosis February 2015 January 2016
NCT00730067 Withdrawn Phase 4 Sildenafil for Chronic Obstructive Pulmonary Disease (COPD) Associated Pulmonary Hypertension June 2012 December 2012
NCT03139084 Withdrawn Efficacy and Safety of Upfront Combination of ΒΟsentan and ΤΑdalafil in Pulmonary Arterial Hypertension December 1, 2017 December 1, 2019
NCT00811486 Withdrawn N/A Body Volume Regulation in Pulmonary Arterial Hypertension With Right Ventricular Failure January 2009 December 2010
NCT01568645 Withdrawn Phase 1 Imatinib and Carvedilol for High Blood Pressure in the Lungs in Adults With Sickle Cell Disease March 2, 2012 December 11, 2012
NCT03012646 Withdrawn Phase 2 Safety and Tolerability of Inhaled Treprostinil in Adult PH Due to COPD April 2017 April 2019
NCT00981591 Withdrawn Phase 1/Phase 2 Inhaled Iloprost as an Adjunct to Inhaled Nitric Oxide in Pediatric Critical Care Patients September 2009 March 2013
NCT02482402 Withdrawn Phase 2 Iloprost for Bridging to Heart Transplantation in PH February 2015 March 17, 2015
NCT01126411 Withdrawn Phase 1/Phase 2 Immunoadsorption in Patients With Pulmonary Hypertension October 2009 December 2013
NCT00323024 Withdrawn Phase 2 Dose Determination Safety and Activity Study of Inhaled NX1011 to Treat Pulmonary Arterial Hypertension September 2006 May 2007
NCT00760916 Withdrawn Phase 3 FREEDOM DR: Oral Treprostinil in Combination With an Endothelin Receptor Antagonist (ERA) and/or a Phosphodiesterase-5 (PDE-5) Inhibitor or as Monotherapy for the Treatment of Pulmonary Arterial Hypertension (PAH) December 2008 January 2009
NCT03317314 Withdrawn Cardiopulmonary Interactions in Patients With Heart Failure July 1, 2017 December 31, 2017
NCT03309592 Withdrawn Phase 4 Efficacy and Safety of Combination Ambrisentan and Tadalafil in Patients With Portopulmonary Hypertension October 12, 2017 November 1, 2018
Disase is a (Disease Ontology)
DOID:10763
Cross Reference ID (Disease Ontology)
ICD10CM:I27.20
Cross Reference ID (Disease Ontology)
MESH:D006976
Cross Reference ID (Disease Ontology)
NCI:C3120
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:155328008
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0020542