Hepatitis B, Chronic

Search with Google Search with Bing
Information
Disease name
Hepatitis B, Chronic
Disease ID
Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT05612581 Active, not recruiting Phase 1/Phase 2 A Platform Study to Evaluate Investigational Therapies in Chronic Hepatitis B Infection May 10, 2023 March 2027
NCT06000657 Active, not recruiting Phase 4 The Efficacy and Safety of Switching to Vemliver Tab From Entecavir in Chronic Hepatitis B Patients Who Pretreated With Entecavir August 28, 2023 December 31, 2025
NCT05473806 Active, not recruiting Phase 4 Effects of Pioglitazone and Evogliptin on Hepatic Fibrosis in Patients With Chronic Hepatitis B With Type 2 Diabetes September 18, 2020 February 19, 2023
NCT05276297 Active, not recruiting Phase 2 A Study on the Safety, Efficacy and Immune Response Following Sequential Treatment With an Anti-sense Oligonucleotide Against Chronic Hepatitis B (CHB) and Chronic Hepatitis B Targeted Immunotherapy (CHB-TI) in CHB Patients Receiving Nucleos(t)Ide Analogue (NA) Therapy March 22, 2022 February 11, 2026
NCT05275023 Active, not recruiting Phase 2 An Efficacy and Safety Study of a Combination of JNJ-73763989, Nucleos(t)Ide Analogs (NA), and a Programmed Cell Death Protein Receptor-1 (PD-1) Inhibitor in Chronic Hepatitis B Participants June 30, 2022 May 30, 2024
NCT05123599 Active, not recruiting Phase 1 A Study of JNJ-73763989, JNJ-64300535, and Nucleos(t)Ide Analogs in Virologically Suppressed, Hepatitis B e Antigen (HBeAg)- Negative Participants With Chronic Hepatitis B Virus Infection December 6, 2021 August 2, 2024
NCT02766933 Active, not recruiting Cameroon Baptist Convention Health Board Chronic Hepatitis B Cohort Study May 2016 December 2024
NCT05630807 Active, not recruiting Phase 3 Study of Bepirovirsen in Nucleos(t)Ide Analogue-treated Participants With Chronic Hepatitis B (B-Well 1) December 7, 2022 May 8, 2026
NCT04782375 Active, not recruiting Phase 4 Safely Discontinue Antiviral Treatment in Patients With Chronic Hepatitis B September 1, 2021 December 2024
NCT05630820 Active, not recruiting Phase 3 Study of Bepirovirsen in Nucleos(t)Ide Analogue-treated Participants With Chronic Hepatitis B (B-Well 2) December 6, 2022 May 8, 2026
NCT04225715 Active, not recruiting Phase 2 A Trial To Evaluate The Efficacy And Safety Of Multiple Combination Therapies In Participants With Chronic Hepatitis B July 5, 2020 January 31, 2025
NCT03866187 Active, not recruiting Phase 1/Phase 2 Safety, Efficacy, Immunogenicity Study of GSK Biologicals' HBV Viral Vector and Adjuvanted Proteins Vaccine (GSK3528869A) in Adult Patients With Chronic Hepatitis B Infection March 28, 2019 October 31, 2025
NCT00435825 Completed Phase 4 A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) in Patients With Hepatitis Be Antigen (HBeAg) Positive Chronic Hepatitis B (CHB). March 2007 December 2010
NCT00436163 Completed Phase 4 A Study of Peginterferon Alfa-2a (40KD) (PEGASYS®) in Participants With Hepatitis B Envelope Antigen (HBeAg) - Positive Chronic Hepatitis B March 2007 May 2010
NCT00442572 Completed Phase 2 SOFIA-LTT Study: A Study of Intermittent Long Term Treatment With PEGASYS (Peginterferon Alfa-2a (40KD)) in Patients With HBeAg Negative Chronic Hepatitis B (CHB). July 3, 2006 April 23, 2012
NCT00487747 Completed Phase 4 A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) in Patients With Chronic Hepatitis B. August 2006 October 2009
NCT00512941 Completed Laboratory Profile of Hepatitis B and C in Users of a Reference Service June 2007 August 2007
NCT00536263 Completed Phase 3 PegIntron Treatment of Chronic Hepatitis B e Antigen-Positive Patients (P05170/MK-4031-327) September 2007 November 2009
NCT00537537 Completed Phase 4 To Evaluate Antiviral Efficacy of Telbivudine in Hepatitis B Antigen Positive (HbeAg-positive) Compensated Chronic Hepatitis B (CHB) August 2007
NCT00614471 Completed Phase 4 A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) Plus Entecavir in Treatment-Naive Patients With HBeAg-Positive Chronic Hepatitis B. August 2007 October 2009
NCT00625339 Completed Phase 4 Continuing Lamivudine Versus Switching to Entecavir in Patients Who Achieved Undetectable HBV DNA February 2008 November 2010
NCT00625560 Completed Phase 4 Continuing Lamivudine vs Switching to Entecavir in Patients With Detectable HBV DNA February 2008 November 2010
NCT00637663 Completed Phase 4 Continuing Lamivudine Versus Switching to Entecavir in Patients Who Achieved Undetectable Hepatitis B Virus DNA February 2008 November 2010
NCT00640588 Completed Phase 3 Prospective Exploratory Study to Describe Hepatitis B Virus (HBV) Kinetics During Treatment With Telbivudine March 2008 December 2009
NCT00646503 Completed Phase 4 Prospective Exploratory Study to Evaluate the Safety and Efficacy of Telbivudine in the Fifth Year of Treatment in Chinese Patients With Compensated Chronic Hepatitis B March 2008 September 2009
NCT00651209 Completed Phase 4 A Single-arm Study Evaluating the Efficacy and Safety of Telbivudine With or Without add-on Tenofovir in Adults With HBeAg-positive Chronic Hepatitis B (CHB) February 2008
NCT00661076 Completed Phase 3 ADVANCE Study: A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) + Adefovir Dipivoxil in Patients With Hbe(-) Chronic Hepatitis B August 2008 May 2011
NCT00686790 Completed Phase 3 Efficacy of Peginterferon Alfa-2b in Previously Untreated Subjects With Chronic Hepatitis B and D Co-infection (Study P04603) December 2005 May 2009
NCT00718887 Completed Phase 4 Suboptimal Responders to Adefovir Switching to Entecavir July 2008 January 2011
NCT00838071 Completed Phase 3 Evaluation of Serum Levels and Pharmacokinetics of a New Hepatitis B Immune Globulin Following Liver Transplantation October 2003 August 2004
NCT00895713 Completed Phase 2 Efficacy and Safety of Intramuscular HBIG Grifols for the Prevention of Recurrence After Liver Transplantation November 2004 July 2005
NCT00922207 Completed Phase 4 A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) in Combination With Adefovir or Entecavir in Patients With HBeAg-Positive Chronic Hepatitis B May 7, 2010 September 29, 2014
NCT00927082 Completed Phase 4 A Follow-Up Study to WV19432, to Evaluate Long Term Post-Treatment Effects of PEGASYS (Peginterferon Alfa-2a(40KD))in Patients With HBeAg Positive Chronic Hepatitis B April 2009 November 2014
NCT00940485 Completed Phase 4 A Study of Combination or Sequential Treatment With PEGASYS (Peginterferon Alfa-2a) and Entecavir in Patients With HBeAg Positive Chronic Hepatitis B April 2009 December 2011
NCT00962533 Completed Phase 4 EFFicacy Optimization Research of Telbivudine Therapy August 2009 August 2012
NCT00962871 Completed Phase 1 A Study of Early Immunologic Response in Asian Patients With Chronic Hepatitis B, Treated With Pegasys (Peginterferon Alfa-2a (40KD)), Nucleoside Analogues, or Both August 2009 February 2012
NCT00962975 Completed Phase 1 A Study of Pegasys Monotherapy in Patients With Chronic Hepatitis B Who Have Participated in Previous Studies September 2009 May 2013
NCT01011738 Completed An Observational Cohort Study in Patients With Chronic Hepatitis B Receiving Pegasys April 11, 2009 November 18, 2014
NCT01013272 Completed N/A Lamivudine Therapy in Patients With Prior Entecavir Treatment and Undetectable Viral Load June 2007 July 2010
NCT01023217 Completed Phase 4 Entecavir Plus Adefovir in Lamivudine-Resistant Chronic Hepatitis B Patients Who Fail Lamivudine Plus Adefovir November 2009 September 2012
NCT01023230 Completed Phase 1 A Study to Assess DV-601 in Subjects With Chronic Hepatitis B September 2009 May 2011
NCT01086085 Completed Phase 4 A Study of Peginterferon Alfa-2a [PEGASYS] in Patients With Chronic Hepatitis B Who Are HBeAg Positive April 2010 March 2013
NCT01155427 Completed Systematic Review of Antiretroviral Treatments for Chronic Hepatitis B (CHB) May 2009 April 2010
NCT00076336 Completed Phase 3 Telbivudine Versus Lamivudine in Adults With Decompensated Chronic Hepatitis B and Evidence of Cirrhosis December 2003
NCT00111943 Completed Phase 2 Safety and Acceptability of a Vaginal Microbicide October 2007
NCT00120354 Completed Phase 4 Long-Term Lamivudine Therapy for Chronic Hepatitis B July 11, 2005 March 31, 2007
NCT00230503 Completed Phase 2 Dose-Ranging Study of Pradefovir in Patients With Compensated Hepatitis B June 2004 December 2006
NCT00347009 Completed Phase 4 Adefovir Dipivoxil For The Treatment Of Patients With Chronic Hepatitis B Related Advanced Fibrosis Or Cirrhosis May 2005 September 2009
NCT00363155 Completed Phase 1/Phase 2 KRN7000 in Chronic Hepatitis B March 2003 July 2006
NCT00395018 Completed Phase 3 Antiviral Activity of Entecavir in Patients Receiving Liver Transplant Due to Chronic Hepatitis B Virus Infection April 2007 March 2011
NCT00403585 Completed Phase 4 Study of Adefovir Dipivoxil for Korean Patients With Chronic Hepatitis B(CHB) Who Have Completed ADF 103814 July 2006 April 2008
NCT00410072 Completed Phase 3 Entecavir Plus Tenofovir Combination Therapy Versus Entecavir Monotherapy in Naive Subjects With Chronic Hepatitis B April 2007 October 2010
NCT00410202 Completed Phase 3 Entecavir Plus Adefovir Combination Therapy Versus Entecavir Monotherapy vs Therapy With Adefovir Plus Lamivudine for Chronic Hepatitis B Infected Subjects With Lamivudine-resistant Virus March 2008 July 2012
NCT00423891 Completed Phase 1/Phase 2 A Study of Entecavir in Pediatric Patients With Chronic Hepatitis B Virus (HBV)-Infection June 30, 2007 September 4, 2017
NCT01095835 Completed Phase 3 A Study of Pegylated Interferon Alfa-2a and Lamivudine in Patients With HBeAg-Negative Chronic Hepatitis B Virus (HBV) February 2005 January 2010
NCT01107483 Completed Observe Change of Endotoxaemia and Related Mediators in Patients With Chronic Hepatitis B Virus (HBV) Infection December 2009 March 2010
NCT01128686 Completed Lamivudine(LAM) Good Responder Study August 2010 June 2011
NCT00034359 Completed Phase 2 Safety and Antiviral Activity Study of ACH-126,443 (Beta-L-Fd4C) in Treatment-naive Adults With Chronic Hepatitis B Virus Infection February 2002 January 2003
NCT01163240 Completed Epidemiological Study in Children and Adolescents With Chronic Hepatitis B June 2009
NCT01205165 Completed Phase 4 An Open Label, Multi Centre Phase IV Study of Adefovir Dipivoxil in Korean Patients With Chronic Hepatitis B (CHB) December 17, 2004 April 28, 2006
NCT01237496 Completed Phase 3 Analysis of HBV-Specific Immune Response in Patients With HBeAg Negative Chronic Hepatitis B Treated With Pegasys (Peginterferon Alfa-2a (40KD)) - Immunology Sub-Study of ML18253 July 2005 September 2009
NCT01283074 Completed An Observational Study of Pegasys (Peginterferon Alfa-2a) in Patients With HbeAg-negative Chronic Hepatitis B (Perseas) May 2009 November 2012
NCT01311947 Completed Hepatitis B Virus Mutants and the Therapeutic Effect of Peginterferon Alfa-2a in HBeAg-Positive Chronic Hepatitis B March 2011 March 2012
NCT01353742 Completed Phase 1 Lamivudine and Adefovir Dipivoxil Fixed Dose Combination February 21, 2011 April 12, 2011
NCT01356901 Completed Persistence, Adherence and Clinical Effectiveness of Entecavir in Chronic Hepatitis B Patients January 2011 January 2015
NCT01376154 Completed Special Drug Use Investigation for ZEFIX (Lamivudine) Tablet (HBV Cirrhosis) June 2006 February 2011
NCT01475851 Completed Phase 3 Phase 3 Study of GSK548470 in Patients With Compensated Chronic Hepatitis B With Poor Response to Other Drugs December 2011 October 2014
NCT01480284 Completed Phase 3 Phase 3 Study of GSK548470 in Patients With Compensated Chronic Hepatitis B Untreated With Nucleic Acid Analogue November 2011 November 2014
NCT01480622 Completed Phase 1 Pharmacokinetic (PK) Profiles of Tenofovir Disoproxil Fumarate (TDF) 300 mg in Healthy Chinese Subjects December 5, 2011 December 30, 2011
NCT01519921 Completed Phase 4 A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) in Patients With HBeAg Positive Chronic Hepatitis B. October 2005 June 2008
NCT01519960 Completed Phase 3 A Study of Pegasys (Peginterferon Alfa-2a) Versus Untreated Control in Children With HBeAg Positive Chronic Hepatitis B July 11, 2012 October 18, 2021
NCT01521975 Completed Phase 4 A Two-year Study of Telbivudine in HBeAg Negative Hepatitis January 1, 2011 May 30, 2014
NCT01641536 Completed Phase 1 Tolerability, Immunogenicity and Efficacy of HB-110 Administered by Electroporation in Chronic Hepatitis B Patients November 2011 April 2013
NCT01645969 Completed A Follow-Up Study of Patients With HBeAg Positive Chronic Hepatitis B Treated With Pegasys (Peginterferon Alfa-2a) in Study ML22265 April 2011 October 2012
NCT01667432 Completed An Observational Study of Peginterferon Alfa-2a (PEGASYS®) in Patients With HBeAg Positive or HBeAg Negative Chronic Hepatitis B July 8, 2011 August 12, 2014
NCT01697501 Completed Phase 3 A Study Evaluating IL28B Polymorphism in Patients With HBeAg-Negative Chronic Hepatitis B Treated With Pegasys (Peginterferon Alfa-2a) in Study ML18253 November 8, 2012 June 21, 2013
NCT01705704 Completed A Retrospective Biomarker Study of Stored Samples Obtained From Patients With Chronic Hepatitis B June 2012 February 2013
NCT01706575 Completed Phase 2 A Study of Pegasys (Peginterferon Alfa-2a) Added to Nucleos(t)Ide Analogue Treatment in Participants With HBeAg-Negative Chronic Hepatitis B Genotype D Showing Stable Hepatitis B Virus (HBV) Deoxyribonucleic Acid (DNA) Suppression January 2013 November 2014
NCT01730508 Completed An Observational Study of Pegasys (Peginterferon Alfa-2a) in Chinese Patients With HBeAg Negative Chronic Hepatitis B November 20, 2012 June 25, 2017
NCT01734018 Completed An Observational Study of Pegasys (Peginterferon Alfa-2a) in Patients With HBeAg-Positive or HBeAg-Negative Chronic Hepatitis B August 2011 August 2012
NCT01787279 Completed Phase 4 An Expanded Access Study of Pegasys (Peginterferon Alfa-2a) in Patients With HBeAg-Negative Chronic Hepatitis B January 2006 May 2009
NCT01855997 Completed A Study to Collect Blood Biomarker Samples From Participants With Chronic Hepatitis B (CHB) Who Received Treatment With Pegasys (Peginterferon Alfa-2a) ± Nucleoside/Nucleotide Analogue August 20, 2013 November 28, 2014
NCT01908660 Completed Hepatic Safety of Currently Used Antiretroviral Regimens in Patients With Chronic Hepatitis Under Real Life Conditions January 2007 October 2015
NCT02075294 Completed Efficacy and Safety Study of Adefovir and Entecavir for Elderly With Chronic Hepatitis B January 2010 October 2012
NCT02081469 Completed Phase 4 Prophylaxis of CHB Patients With Malignant Tumor Receiving Chemotherapy March 17, 2014 August 5, 2019
NCT02097004 Completed Phase 4 Study of Therapeutic Vaccination With Intensified Schedule Plus Pegasys Dual Therapy on Chronic Hepatitis B Infection April 2014 March 13, 2018
NCT02129829 Completed PROLIFICA - West African Treatment Cohort for Hepatitis B October 2011 July 31, 2018
NCT02167113 Completed Collection of Samples for the Clinical Evaluation of the Aptima HBV (Hepatitis B Virus) Quant (Quantification) Assay March 2014 January 23, 2018
NCT02195518 Completed Phase 4 Tenofovir Disoproxil Fumarate (TDF) 300mg 3 Years RD Therapy Chinese Chronic Hepatitis B (CHN) CHB Multiple Nucleos(t)Ide Analogues (NAs) Failure Points Pts PH4 PMS Study March 18, 2015 August 14, 2018
NCT02201407 Completed An Observational Study in Participants With Chronic Hepatitis B (CHB) Receiving Therapy With Peginterferon Alfa-2a 40 Kilodaltons (kD) (PEGASYS) - The PRO B Study December 18, 2014 April 10, 2017
NCT02224456 Completed Phase 4 Efficacy and Safety Study of Tenofovir Disoproxil Fumarate (TDF) in Chinese Chronic Hepatitis B (CHB) Subjects With Advanced Fibrosis & Compensated Cirrhosis March 25, 2015 December 4, 2020
NCT02338674 Completed Phase 1/Phase 2 TDF and LdT in Immune-tolerant CHB Patients Awaiting Assisted Reproduction October 2014 October 2017
NCT02360592 Completed Phase 4 Combination Therapy With Interferon Plus Interleukin 2 and Hepatitis B Vaccine in Chronic Hepatitis B Patients June 2013 April 2017
NCT02366208 Completed Phase 2 Phase II Trial for Combination Treatment of PEG-Tα1 and Adefovir for HBeAg Positive Chronic Hepatitis B May 2011 August 2013
NCT02391805 Completed Phase 2 A Study of Treatment With RO6864018 in Virologically Suppressed Participants With Chronic Hepatitis B Virus (HBV) Infection May 17, 2015 October 16, 2017
NCT02499562 Completed Phase 2 A Phase II Clinical Trial of Hydronidone Capsules(F351) in Patients With Liver Fibrosis Induced by HBV Chronic Hepatitis June 25, 2015 November 20, 2020
NCT02570191 Completed Phase 4 A Study of PEGASYS (Peginterferon Alfa-2a [40KD]) in Patients With Hepatitis B e Antigen (HBeAg)-Negative Chronic Hepatitis B Virus (HBV) November 2004 February 2007
NCT02598063 Completed Phase 4 A Study to Evaluate Efficacy and Safety of Peginterferon Alfa-2a (Pegasys) and Adeforvir Dipivoxil (ADV) in Participants With Lamivudine-Resistant Hepatitis B e Antigen (HBeAg)-Positive Chronic Hepatitis B October 2005 April 2009
NCT02600117 Completed Phase 3 Use of TDF in Patients With Inactive Chronic Hepatitis B Infection January 26, 2016 February 28, 2023
NCT02604823 Completed Phase 4 A Study of Peginterferon Alfa-2a (Pegasys) in Participants With Hepatitis B E-Antigen (HBeAg)-Positive Chronic Hepatitis B Virus (HBV) November 2003 November 2005
NCT02631096 Completed Phase 2 Study of ARB-001467 in Subjects With Chronic HBV Infection Receiving Nucleos(t)Ide Analogue Therapy December 2015 May 18, 2018
NCT02646163 Completed Phase 1/Phase 2 Therapeutic Safety and Efficacy of REP 9AC (REP 2055) in HBV or HCV Infected Patients January 2009 December 2012
NCT02646189 Completed Phase 1/Phase 2 Therapeutic Safety and Efficacy of REP 2139 (REP 9AC') in HBV Infected Patients August 2011 August 2013
NCT02693652 Completed Phase 1/Phase 2 A Study to Evaluate the Safety and Efficacy of Therapeutic Hepatitis B Vaccine October 28, 2014 August 22, 2017
NCT02726789 Completed Phase 2 Combination Treatment With REP 2139-Ca and Pegasys in Patients With Chronic Hepatitis B October 2012 December 2016
NCT02791269 Completed Phase 4 A Study of Peginterferon Alfa-2a in Participants With Chronic Hepatitis B Virus (HBV) in an Expanded Access Program January 2006 July 2008
NCT02876419 Completed A Long Term Follow-up Study of Patients From the REP 301 Protocol August 2016 December 2019
NCT02952924 Completed Phase 1 A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of RO7049389 in Healthy Volunteers and Chronic Hepatitis B Virus (HBV) Infected Participants December 14, 2016 March 16, 2022
NCT02956850 Completed Phase 1 A Study in Healthy Volunteers and in Participants With Chronic Hepatitis B to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of RO7020531 December 12, 2016 June 15, 2021
NCT03258710 Completed Phase 4 A Study of Switching From Entecavir to Tenofovir Disoproxil Fumarate in Subjects With Chronic Hepatitis B October 2, 2017 November 25, 2019
NCT03272009 Completed Phase 1 Evaluation of the Safety and Pharmacology of EYP001 in HBV Subjects September 21, 2017 July 30, 2018
NCT03300414 Completed Biologic Basis of Liver Cancer From Chronic Hepatitis B March 20, 2017 December 14, 2018
NCT03320616 Completed Phase 1 EYP001a Food Effect Study in Subjects With Chronic Hepatitis B Virus (HBV) Infection February 10, 2017 October 12, 2017
NCT03350074 Completed HBV Envelope Proteins Variability on HBs Antigen Clearance Under Nucleos(t)Ide Analogue Therapy November 5, 2013 September 1, 2017
NCT03463369 Completed Phase 1 A First-In-Human Study to Evaluate Safety, Tolerability, Reactogenicity, and Immunogenicity of JNJ-64300535, a DNA Vaccine, Administered by Electroporation-Mediated Intramuscular Injection, in Participants With Chronic Hepatitis B Who Are on Stable Nucleos(t)Ide Therapy and Virologically Suppressed April 18, 2018 March 23, 2021
NCT03468907 Completed Phase 4 The Safety of Anti-viral Therapy in Preventing HBV MTCT in Pregnant Women After Discontinuation June 1, 2015 December 31, 2017
NCT03469583 Completed Phase 1 Drug Drug Interaction Study for EYP001 With Entecavir February 12, 2018 July 20, 2018
NCT03471624 Completed Phase 4 Treatment Outcomes in Chronic Hepatitis B Patients on Sequential Therapy With Tenofovir Alafenamide (TAF) May 1, 2018 April 19, 2022
NCT03485534 Completed Phase 4 Evaluate the Efficacy and Safety to Tenofovir Disoproxil in Chronic Hepatitis B Patients January 23, 2018 November 4, 2019
NCT03681132 Completed Phase 4 The Norwegian Nucleoside Analogue Stop Study September 20, 2018 January 31, 2023
NCT03772249 Completed Phase 1 Study of Safety and Tolerability of DCR HBVS December 28, 2018 July 12, 2022
NCT03778567 Completed Phase 4 Renoprotective Effects of Telbivudine in Chronic Hepatitis B August 1, 2013 May 31, 2018
NCT03977857 Completed Prediction Model Based on Computed Tomography Liver Volume for the Short-term Mortality in Hepatitis B Related Acute-on-Chronic March 1, 2019 December 31, 2019
NCT03982186 Completed Phase 2 A Study of Different Combination Regimens Including JNJ-73763989 and/or JNJ-56136379 for the Treatment of Chronic Hepatitis B Virus Infection August 1, 2019 April 26, 2022
NCT04082338 Completed N/A Chronic HBV Management for Asian American April 1, 2019 March 31, 2022
NCT04129554 Completed Phase 2 A Study of JNJ 73763989+JNJ 56136379+Nucleos(t)Ide Analog (NA) Regimen Compared to NA Alone in e Antigen Negative Virologically Suppressed Participants With Chronic Hepatitis B Virus Infection November 6, 2019 June 9, 2022
NCT04248426 Completed Phase 1 A Phase 1 Double-Blinded Study for Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of ATI-2173 in Healthy Subjects and Subjects With Chronic Hepatitis B Virus Infection February 5, 2020 May 18, 2021
NCT04289987 Completed Phase 2 A Study to Evaluate the Efficacy and Safety of Therapeutic Hepatitis B Vaccine February 19, 2020 December 4, 2023
NCT04365933 Completed Phase 2 A Study of the Oral Farnesoid X Receptor Modulator EYP001a to Assess Its Safety and Anti-viral Effect in Chronic Hepatitis B Patients in Combination With Pegylated Interferon alpha2a Alone and With Entecavir May 25, 2020 November 29, 2021
NCT04426968 Completed Phase 2 A Phase II Study of Hepalatide in Subjects With Chronic Hepatitis B June 18, 2021 November 29, 2023
NCT04439539 Completed Phase 2 A Study of JNJ-73763989, Pegylated Interferon Alpha-2a, Nucleos(t)Ide Analog (NA) With or Without JNJ-56136379 in Treatment-naive Participants With Hepatitis B e Antigen (HBeAg) Positive Chronic Hepatitis B Virus (HBV) Infection September 14, 2020 February 13, 2024
NCT04507269 Completed Phase 2 Study of VIR-2218 in Patients With Chronic Hepatitis B in Mainland China August 18, 2020 September 30, 2021
NCT04667104 Completed Phase 2 A Study of JNJ-73763989, JNJ-56136379, Nucleos(t)Ide Analogs, and Pegylated Interferon Alpha-2a in Virologically Suppressed Participants With Chronic Hepatitis B Virus Infection February 1, 2021 April 17, 2023
NCT04749368 Completed Phase 2 Study to Investigate the Safety and Efficacy of BRII-835 and BRII-179 Combination Therapy Treating Chronic Hepatitis B Virus (HBV) Infection April 12, 2021 July 4, 2023
NCT05107778 Completed Phase 2 Study to Evaluate Safety and Efficacy of ASC42 Combined With ETV and PEG-IFN α-2a in Subjects With HBV January 10, 2022 December 14, 2023
NCT05242445 Completed Phase 1 A Study of Cetrelimab in Participants With Chronic Hepatitis B Virus Infection April 19, 2022 May 9, 2023
NCT05265026 Completed N/A Aerobic Exercise Training in Patients With Chronic Hepatitis B and Hepatic Steatosis March 14, 2022 October 1, 2023
NCT05391360 Completed Phase 1 Evaluation Freethiadine Tolerance in Healthy Subjects and Patients With Chronic Hepatitis B, Pharmacokinetics Characteristics and Antiviral Activity of Ⅰ Phase of Study October 11, 2021 January 17, 2023
NCT05470829 Completed Phase 1 A Multiple-dose Study in Chinese Subjects to Evaluate Safety,Tolerability,PK and PD of ZM-H1505R May 27, 2021 November 17, 2021
NCT06452693 Not yet recruiting Phase 1/Phase 2 A Clinical Study to Evaluate the Efficacy of TQA3038 Injection in Patients With Chronic Hepatitis B June 2024 September 2026
NCT05328427 Not yet recruiting N/A Discontinuation of Antiviral Therapy as a Strategy to Cure Hepatitis B May 15, 2022 December 31, 2025
NCT06041022 Not yet recruiting A Non-invasive Model to Predict Antiviral Therapy in Gray Zone of Chronic Hepatitis B October 1, 2023 December 31, 2023
NCT05045261 Recruiting Phase 2 ANRS HB07 IP-Cure-B Proof of Concept (PoC) Clinical Trial. Educating the Liver Immune Environment Through TLR8 Stimulation Followed by NUC Discontinuation February 1, 2022 June 30, 2024
NCT04035837 Recruiting Phase 4 The Clinical Cure Project of Chronic Hepatitis B in China May 16, 2018 June 30, 2024
NCT04166266 Recruiting Observatory of Efficacy and Safety of Bulevirtide in Patients With Chronic HBV/HDV Co-infection February 19, 2020 September 30, 2027
NCT05708560 Recruiting Relationship Between MAFLD and Liver Fibrosis Progression in Patients With Chronic Hepatitis B: a Multicenter Retrospective Cohort Study March 1, 2022 January 31, 2023
NCT05376124 Recruiting Clinical Characteristics, Natural Outcome and Treatment Optimization of Refractory January 1, 2022 December 31, 2025
NCT04856085 Recruiting Phase 2 Study of VIR-2218, VIR-3434, and/or PEG-IFNα in Subjects With Chronic Hepatitis B Virus Infection July 11, 2021 June 2027
NCT04780204 Recruiting Phase 4 Effectiveness of Antiviral Treatment in Cirrhotic Patients With Low-level Hepatitis B Virus DNA Levels August 23, 2021 December 2026
NCT05382013 Recruiting Phase 4 Efficacy and Safety of Avatrombopag for Treating TCP in HBV-ACLF Patients Receiving ALSS Treatment April 27, 2022 April 30, 2024
NCT06245291 Recruiting Phase 2 Study of Imdusiran (AB-729) in Combination With Intermittent Dosing of Durvalumab in Subjects With Chronic HBV Infection May 1, 2024 July 2027
NCT05182463 Recruiting Phase 4 Peginterferon Treatment Study for Inactive Chronic Hepatitis B Patients January 8, 2022 November 30, 2029
NCT06216470 Recruiting Phase 2 Vaccinal Effect of HBsAg Monoclonal Ab VIR-3434 in Chronic Hepatitis B Infection [VISION] March 13, 2024 December 2029
NCT06023745 Recruiting Study IL- 35 Level and Fibronectin Type Ⅲ Domain Containing Protein 5 \ Irsin (FNDC5 rs3480) Gene Variations in Chronic Hepatitis B. July 20, 2023 September 2023
NCT04585165 Recruiting User-friendly HIV Testing and Counseling Services October 19, 2020 December 2024
NCT06196632 Recruiting Development and Validation of Models to Predict Functional Cure in Patients With CHB After Peg-IFN Based Therapy January 6, 2024 December 31, 2025
NCT05172453 Recruiting Mother-to-child Transmission of HBV in China July 1, 2015 December 31, 2025
NCT06115993 Recruiting Phase 1 A Study to Evaluate the Safety and Efficacy of AHB-137 in Healthy Participants and Chronic Hepatitis B Patients August 3, 2023 October 2024
NCT05867056 Recruiting Phase 1 Study of IMC-I109V in Non-cirrhotic HBeAg-negative Chronic HBV Infection August 12, 2020 December 15, 2024
NCT05484466 Recruiting Phase 2 A Study to Evaluate the Efficacy and Safety of ZM-H1505R in Combination With ETV Compared With ETV Monotherapy in Patients With CHB November 11, 2022 December 30, 2024
NCT05977283 Recruiting HBsAg Declined Patients Follow-up Study May 11, 2023 March 2028
NCT05937178 Recruiting Real-world Study Optimizing Nucleotide-analogues January 31, 2023 January 31, 2029
NCT05922306 Recruiting Early Phase 1 Efficacy of NA Combined With PEG-IFN-α2b in the Continuous Versus Pulsed Treatment of Patients With Chronic Hepatitis B July 2023 December 2027
NCT05870969 Recruiting Digitalized Surveillance Management for Liver Cancer Risk Population in Improving Eearly Diagnosis Efficancy in Chinese Population (dSEARCH) March 1, 2023 March 2028
NCT04536532 Suspended Phase 1/Phase 2 Evaluation HEC121120 Tolerance in Healthy Subjects and Patients With Chronic Hepatitis B, Pharmacokinetics Characteristics and Antiviral Activity of Ⅰ Phase of Study October 12, 2020 December 30, 2023
NCT04684914 Terminated Phase 2 HepTcell Immunotherapy in Patients With Inactive Chronic Hepatitis B (CHB) December 26, 2020 April 17, 2024
NCT03164889 Terminated N/A Clinical and Basic Research of ETV Plus GM-CSF in Chronic Hepatitis B Patients January 2017 December 1, 2021
NCT05423106 Terminated Phase 1 A Single and Multiple Ascending Dose Study of JNJ-64457744 July 4, 2022 March 20, 2023
NCT03932513 Terminated Phase 2 Evaluating the Effects of Inarigivir on Immune Response and Viral Markers in Chronic Hepatitis B Patients April 11, 2019 December 21, 2019
NCT01341106 Terminated Phase 4 Induction of Fibrosis Regression on Patients With Chronic Hepatitis B Infection April 2011 April 2015
NCT00460850 Terminated Phase 4 A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) in Patients With Lamivudine Resistant HBeAg-Negative Chronic Hepatitis B. September 2007 June 2008
NCT04023721 Terminated Phase 2 Evaluating the Safety and Efficacy of Inarigivir in Non-cirrhotic, Hepatitis B e Antigen-negative Subjects Infected With HBV Virus and Receiving or Stopping Treatment With a NUC Inhibitor June 18, 2019 July 16, 2020
NCT04059198 Terminated Phase 2 Evaluating the Safety and Efficacy of Inarigivir in Non-cirrhotic Treatment Naive Subjects Infected With Hepatitis B Virus October 10, 2019 April 2, 2020
NCT00230490 Terminated Phase 2 Open-label Treatment Extension Study for Patients Who Complete Study RNA200103-201 June 2005 May 2007
NCT01641926 Terminated Phase 3 A Study of the Safety and Efficacy of Pegylated Inferferon Alfa-2b (PEG-Intron™) Versus Pegylated Interferon Alfa-2a (PEGASYS™) in Participants With Chronic Hepatitis B (P08450) November 26, 2012 January 21, 2016
NCT01794234 Terminated An Observational Study of Pegasys (Peginterferon Alfa-2a) in Patients With Chronic Hepatitis B Who Have Failed Antiviral Treatment With Nucleoside (Nucleotide) Analogues August 2012 September 2013
NCT01886300 Terminated An Observational Study of Pegasys (Peginterferon Alfa-2a) in Patients With HBeAg-Positive Chronic Hepatitis B in Vietnam September 2012 May 2013
NCT04465916 Terminated Phase 2 Study of EYP001a to Assess Its Safety and Anti-viral Effect in CHB Patients in Combination With NA (ETV or TD) May 12, 2020 November 25, 2021
NCT02065336 Terminated Phase 2 A Multicenter Study to Determine the Depth and Duration of Hepatitis B Surface Antigen (HBsAg) Reduction After Single or Multiple Doses of ARC-520, in Combination With Entecavir in Patients With Chronic Hepatitis B Virus (HBV) Infection March 2014 January 2017
NCT02128503 Terminated N/A Prevalence and Clinical Course of Chronic Hep B Infection in IBD and Rheumatologic Disease February 2013 October 16, 2015
NCT02498275 Terminated Effect of RO6871765 and RO7011785 on Immune Response With the Stimulation of Peripheral Blood Mononuclear Cells (PBMCs) in Chinese Healthy Volunteers and Chronic Hepatitis B Patients July 2014 August 2014
NCT04847440 Terminated Phase 2 A Study of Safety and Efficacy of ATI-2173 in Combination With Tenofovir Disoproxil Fumarate in Subjects With Chronic Hepatitis B Virus Infection and in Subjects With Hepatitis D Virus Coinfection March 30, 2021 September 1, 2022
NCT05005507 Terminated Phase 2 A Study of JNJ-73763989, Pegylated Interferon Alpha-2a and Nucleos(t)Ide Analogs in Participants With Chronic Hepatitis B Virus Infection November 3, 2021 December 29, 2021
NCT02604355 Terminated Phase 1 A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7020322 Following Oral Administration in Healthy Participants and Chronic Hepatitis B Patients November 28, 2015 May 9, 2016
NCT02826018 Terminated Phase 1 A Study of ALN-HBV in Healthy Adult Volunteers and Non-cirrhotic Patients With Chronic Hepatitis B Virus (HBV) Infection June 24, 2016 October 2017
NCT02605252 Unknown status N/A New Strategy Study of Functional Cure of Chronic Hepatitis B March 2016
NCT01220596 Unknown status Phase 3 Efficacy Study of Sequential Therapy of Peginterferon Alfa-2a Following Entecavir in Patient With Chronic Hepatitis B. June 2010 June 2013
NCT01456312 Unknown status Phase 4 HBsAg Related Response Guided Therapy September 2012 August 2016
NCT00810524 Unknown status Phase 4 Influence of Antiviral Treatment to the Long-Term Prognosis of Patients With Chronic HBV Infection January 2007 January 2017
NCT04201808 Unknown status Phase 4 Efficacy and Safety of TAF in Patients With Suboptimal Response to Other Nucleos(t)Ides May 1, 2021 September 30, 2023
NCT04211805 Unknown status Maternal Therapy With TAF Versus TDF to Prevent Vertical Transmission of Hepatitis B January 27, 2020 September 30, 2021
NCT00917761 Unknown status Phase 4 Entecavir and Pegasys Sequential Therapy Versus Pegasys for HBeAg Negative Chronic Hepatitis B February 2007 December 2013
NCT04237376 Unknown status Chronic HBV Infection in Pregnant Women Taking TAF to Prevent Vertical Transmission April 9, 2019 September 30, 2020
NCT00823550 Unknown status Phase 4 Antiviral Therapy in Hepatitis B Virus (HBV)-Related Advanced Liver Disease Patients January 2009 July 2015
NCT05168293 Unknown status Effect of Entecavir Versus Tenofovir on HBV DNA Level in Peripheral Blood Mononuclear Cells February 1, 2022 May 1, 2023
NCT02719808 Unknown status Study of Antiretroviral Therapy to Prevent HBV Intrauterine Infection March 2015 December 2022
NCT00815464 Unknown status N/A A Single-Arm Study Evaluating the Efficacy of Liquid Acupuncture Therapeutics in Chronic Hepatitis B March 2009 March 2010
NCT00154869 Unknown status Phase 3 Peginterferon Alfa-2a Plus Ribavirin for Chronic Hepatitis C/Hepatitis B Co-Infection and Chronic Hepatitis C June 2004 August 2007
NCT03759782 Unknown status Phase 3 Ribavirin to Enhance Hepatitis B Virus Nucleotide Analog Antiviral Activity January 10, 2019 September 30, 2022
NCT04538651 Unknown status A Cross-sectional Study for Renal Function of Patients With Chronic Hepatitis B in China August 31, 2020 August 31, 2021
NCT02148562 Unknown status Assessment of Hepatitis B Virus Intra-host Population and Host-specific Immune Marker Diversity April 2014 December 2017
NCT04597164 Unknown status Combination of DPMAS and Low Volume PE for Patients With HBV Related ACLF December 22, 2020 September 30, 2023
NCT03539016 Unknown status Observational Study on Pregnant Women With Chronic Hepatitis B and Their Infants July 2015 May 2018
NCT01090531 Unknown status Patients With Chronic Hepatitis B and Low Viremia Not Receiving Antiviral Therapy August 2009 August 2021
NCT04724785 Unknown status Real World Study About Anti-viral Regimen Adjustment on Achieving Complete Response in CHB Patients December 1, 2020 December 31, 2022
NCT02267473 Unknown status Hepatitis B Patients Under Oral Nucleos(t)Ide Treatment With Intermittent Assessment of Kidney Function October 2014 December 2020
NCT02327416 Unknown status Phase 3 A Prospective Clinical Trial in Chronic Hepatitis B Patients NAs (Nucleotides or Nucleosides) Experienced (Anchor Study) October 2014 June 2019
NCT02327663 Unknown status Phase 4 Emtricitabine for Naive Chinese Chronic Hepatitis B Patients December 2014 December 2017
NCT02327676 Unknown status Phase 4 Emtricitabine for Naive Child Chinese Chronic Hepatitis B Patients January 2015 July 2016
NCT02327689 Unknown status Phase 4 Emtricitabine Plus Adefovir Dipivoxil for Naive Chinese HBV Related Cirrhosis Patients January 2015 July 2017
NCT02327702 Unknown status Phase 4 Emtricitabine for Naive Chinese Pregnant Chronic Hepatitis B Patients January 2015 July 2017
NCT02327715 Unknown status Phase 4 Emtricitabine for Prevention of Vertical Transmission of HBV in Chinese Pregnant HBsAg Positive Patients January 2015 July 2016
NCT05398393 Unknown status N/A An Experimental Study on the Effect of Tenofovir Amibufenamide on Blood Lipid During Anti-HBV Treatment January 1, 2022 June 30, 2023
NCT03459768 Unknown status Cohort Study on People Who Inject Drugs in Senegal August 24, 2016 June 30, 2021
NCT00860626 Unknown status N/A Early Response to Interferon Combined Short-Term Nucleoside Analogue Therapy in HBeAg(+) Chronic Hepatitis B January 2008 February 2010
NCT02366247 Unknown status Phase 3 Phase Ⅲ Trial for Combination Treatment of PEG-Tα1 and Adefovir for HBeAg-positive Chronic Hepatitis B August 2013 February 2016
NCT04805034 Unknown status Predictive Model for Prognosis of Chronic HBV Infection Mothers April 16, 2021 January 31, 2024
NCT02392598 Unknown status A Hepatitis B With Hepatic Steatosis Study August 2015 December 2020
NCT02482272 Unknown status Phase 4 Compare Continuing Lamivudine Plus Adefovir or Adefovir Versus Switching to Entecavir Plus Adefovir in Patients With LAM-resistant Chronic Hepatitis B May 2015 May 2017
NCT05177926 Unknown status Phase 4 Preventing Mother-to-child Transmission of Hepatitis B Virus With Tenofovir Alafenamide (TAF) April 4, 2021 December 31, 2023
NCT02974829 Unknown status REALM China Extension Study May 2016
NCT02510963 Unknown status N/A Optimal Time for Tenofovir Treatment of Anti-Hepatitis B Virus (HBV) During the Pregnancy November 2015 August 2017
NCT03358108 Unknown status A Prospective,Observational Follow-up Study of Nucleoside Treated Patients With Chronic Hepatitis B (OCEAN Study) February 27, 2018 December 1, 2022
NCT02588937 Unknown status Phase 4 Active Drug Comparative Trial to Evaluate the Antiviral Activity and Safety in Chronic Hepatitis B Patients October 2015 June 2017
NCT04886102 Unknown status Molecular Epidemiology of Hepatitis B in Cayenne General Hospital, French Guiana February 11, 2021 February 1, 2022
NCT02826070 Unknown status Phase 4 EFFORT Further Extension Study April 2015 October 2017
NCT05286216 Unknown status N/A The Effect of Education on Drug Compliance and Quality of Life in Hepatitis B Patients April 15, 2022 December 25, 2022
NCT00921180 Unknown status Phase 4 Entecavir and Pegasys Sequential Therapy Versus Pegasys for HBeAg Positive Chronic Hepatitis B February 2007 December 2013
NCT05057065 Unknown status A Clinical Research on Disease Progression and Intervention of Chronic HepatitisB September 15, 2021 June 1, 2023
NCT04070079 Unknown status Phase 4 Tenofovir Alafenamide With Fine Needle Aspiration Biopsy in Chronic Hepatitis B: January 29, 2019 December 31, 2022
NCT04133259 Unknown status Phase 2 Evaluate the Efficacy and Safety of HLX10 in Chronic Hepatitis B Patients December 31, 2019 July 30, 2022
NCT04160897 Unknown status Risk of Hepatocellular Carcinoma in Patients Treated With ETV vs TDF for Chronic Hepatitis B With Compensated Cirrhosis October 22, 2019 October 31, 2020
NCT01529255 Unknown status Phase 4 EFFORT Extension Study August 2011 December 2015
NCT05550519 Withdrawn Early Phase 1 A Study in Chronic Hepatitis B e-Antigen Negative Participants After Discontinuation of Nucleos(t)Ide Analog (NA) Treatment October 31, 2022 August 28, 2025
NCT00800787 Withdrawn Phase 3 Nabi-HB Administered Subcutaneously in Patients With Hepatitis B Virus Post Liver Transplantation April 2010 September 2010
NCT01179594 Withdrawn Phase 4 A Study of 48 Versus 96 Weeks of Peginterferon Alfa-2a [Pegasys] Treatment, With or Without Entecavir, in Patients With Chronic Hepatitis B. September 18, 2010 November 2014
NCT03125213 Withdrawn Phase 2 A Study Evaluating AL-3778 in Combination With Peginterferon Alpha-2a in Chronic Hepatitis B Subjects September 12, 2017 February 15, 2019
NCT00710216 Withdrawn Phase 4 Comparison of Telbivudine Versus Lamivudine on the Early Dynamics and Kinetics of Viral Suppression in Chronic Hepatitis B
NCT00986778 Withdrawn Phase 4 Entecavir Plus Adefovir in Lamivudine-Resistant Patients December 2009 June 2014
MeSH unique ID (MeSH (Medical Subject Headings))
D019694