Acute Lung Injury

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Information
Disease name
Acute Lung Injury
Disease ID
Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT00036062 Completed Phase 1/Phase 2 A Phase II Study to Determine the Efficacy and Safety of Sivelestat in Subjects With Acute Lung Injury August 2001 December 2002
NCT00127491 Completed N/A Mechanical Ventilation, Directed by Esophageal Pressure Measurements, in Patients With Acute Lung Injury May 2004 May 2010
NCT00133614 Completed Phase 3 Prone Positioning in Pediatric Acute Lung Injury August 2001 April 2004
NCT00143468 Completed N/A The Specific Elastance in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients March 2005 May 2008
NCT00188058 Completed N/A Comparison of 2 Strategies of Adjustment of Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome September 2002 February 2006
NCT00219375 Completed Phase 4 Study of Sivelestat Sodium Hydrate in Acute Lung Injury (ALI) Associated With Systemic Inflammatory Response Syndrome (SIRS) in Japan June 2004
NCT00290602 Completed Phase 2 Early Low Dose Steroid Therapy of Acute Respiratory Distress Syndrome February 2004 December 2006
NCT00351533 Completed Phase 2 A Phase II Randomized Trial of Fish Oil in Patients With Acute Lung Injury (ALI) July 2006 August 2009
NCT00435110 Completed Effects of PEEP and FIO2 in ALI and ARDS May 2004 October 2005
NCT00521625 Completed Epidemiologic Multicenter Study on Mechanical Ventilation Management in Children With Acute Lung Injury June 2007 November 2007
NCT00559130 Completed N/A Efficacy Study of CytoSorb Hemoperfusion Device on IL-6 Removal in ARDS/ALI Patients With Sepsis November 2007 June 2011
NCT00568659 Completed N/A The Specific Lung Elastance in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients in Supine and Prone Position December 2007 January 2015
NCT00624650 Completed Phase 2 Hemodynamics and Extravascular Lung Water in Acute Lung Injury February 2008 January 2011
NCT00655928 Completed Phase 2 Modulation of Lung Injury Complicating Lung Resection August 2007 July 2009
NCT00659152 Completed Morphofunctional Lung Analysis by Positron Emission Tomography February 2008 December 2013
NCT00736892 Completed Incidence of Acute Lung Injury: The Alien Study September 2008 May 2010
NCT00747045 Completed N/A Lung Protective Ventilation in Pulmonary Thromboendarterectomy (PTE) Patients August 2008 March 2011
NCT00786292 Completed N/A Evaluation of Variable Pressure Support Ventilation in the Therapy of Acute Lung Injury July 2009 September 2012
NCT00789685 Completed Phase 1/Phase 2 Safety, Tolerability and Preliminary Efficacy of FP-1201 in ALI and ARDS. Phase I/II February 2009 September 2011
NCT00811629 Completed Influence of Acute Respiratory Distress Syndrome (ARDS) and Severe Sepsis on sRAGE Levels in ICU Patients January 2009 July 2009
NCT00819871 Completed Nuclear Factor Kappa-B (NFKB1) Polymorphism and Organ Injury After Cardiac Surgery May 2008 December 2008
NCT00825357 Completed Biological Markers to Identify Early Sepsis and Acute Lung Injury September 2006 August 2011
NCT00826072 Completed Inflammatory Genetic Polymorphism and Acute Lung Injury After Cardiac Surgery May 2008 January 2009
NCT00830284 Completed N/A Efficacy and Safety of a Lung Recruitment Protocol in Children With Acute Lung Injury November 2008 December 2012
NCT00852605 Completed Phase 1/Phase 2 Acute Lung Injury After Allogeneic Transplantation - Diagnosis and Early Treatment December 2001
NCT00879606 Completed Phase 2 Anti-TF Antibody (ALT-836) to Treat Septic Patients With Acute Lung Injury or Acute Respiratory Distress Syndrome April 2009 January 2013
NCT00889772 Completed Lung Injury Prediction Study March 2009 February 2010
NCT00963066 Completed N/A NAV-ALI: Neurally Adjusted Ventilatory Assist in Patients Recovering Spontaneous Breathing After Acute Lung Injury August 2009 November 2009
NCT00980915 Completed Timing and Intensity of the Exposures and Attributable Burden of Acute Lung Injury December 2008 December 2020
NCT00999713 Completed Phase 2/Phase 3 CALIPSO: Calfactant for Acute Lung Injury in Pediatric Stem Cell Transplant and Oncology Patients June 2010 October 2015
NCT01050699 Completed Phase 4 Sleep Intervention During Acute Lung Injury August 2009 January 2019
NCT01089400 Completed Immuno-virological Characterization of Severe H1N1v Influenza Infection in Bronchoalveolar Lavage October 2009 April 2011
NCT01142544 Completed Incidence of Acute Lung Injury in Children February 2010 March 2011
NCT01144585 Completed N/A Effects of Remote Ischemic Preconditioning and Postconditioning on Lung Injury During Cardiopulmonary Bypass May 2010 November 2010
NCT01150864 Completed N/A Effects of Airway Conditioning Devices on Ventilator Associated Pneumonia:a Randomized Clinical Trial April 2010 March 2017
NCT01159392 Completed Alveolar Recruitment in Brain Injury February 2001 November 2003
NCT01187004 Completed Extracardiac Complications After Cardiac Surgery April 2007 December 2009
NCT01194895 Completed N/A A Trial to Evaluate the Impact of Lung-protective Intervention in Patients Undergoing Esophageal Cancer Surgery August 2010 March 2013
NCT01260259 Completed N/A Seattle Cardiorenal Remote Ischemic Preconditioning Trial December 2010 August 2013
NCT01270295 Completed Soluble Forms and Ligands of RAGE in ALI/ARDS (SoLiRAGE). January 2011 January 2013
NCT01274481 Completed Phase 1 Iloprost Effects on Gas Exchange and Pulmonary Mechanics March 2011 July 2012
NCT01284452 Completed N/A Efficacy of Hydrocortisone in Treatment of Severe Sepsis/Septic Shock Patients With Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS) December 2010 March 2015
NCT01320384 Completed Phase 2/Phase 3 Clinical Effect of the Association of Noninvasive Ventilation and High Flow Nasal Oxygen Therapy in Resuscitation of Patients With Acute Lung Injury (FLORALI Study) March 2011 July 2013
NCT01321398 Completed Transpulmonary Pressure Gradients in High Frequency Oscillation October 2010 March 2013
NCT01322295 Completed Human Bronchial Microdialysis in Open Aortic Aneurysm Repair March 2011 December 2011
NCT01335932 Completed Phase 2 Ganciclovir/Valganciclovir for Prevention of CMV Reactivation in Acute Injury of the Lung and Respiratory Failure March 10, 2011 October 28, 2016
NCT01434121 Completed Phase 1/Phase 2 Ascorbic Acid (Vitamin C) Infusion in Human Sepsis May 2010 September 2012
NCT01438853 Completed Phase 1 Effects of TNX-832 (Sunol cH36) in Subjects With Acute Lung Injury/Acute Respiratory Distress Syndrome December 2004 February 2008
NCT01474863 Completed Phase 2 Citrulline in Severe Sepsis August 2012 March 2016
NCT01486342 Completed PET Imaging in Patients at Risk for Acute Lung Injury October 2011 October 2012
NCT01502332 Completed N/A Intensive Alveolar Recruitment Protocol After Cardiac Surgery December 2011 March 2014
NCT01532024 Completed Early Phase 1 Exploratory Clinical Study of Neutrophil Activation Probe (NAP) for Optical Molecular Imaging in Human Lungs October 2014 September 2, 2016
NCT01552070 Completed Phase 2 Recruitment on Extravascular Lung Water in Acute Respiratory Distress Syndrome (ARDS) September 2010 July 2013
NCT01581229 Completed N/A Early Use of Noninvasive Positive Pressure Ventilation for Intro-pulmonary Acute Lung Injury June 2012 December 2016
NCT01627613 Completed Phase 2 Study in Intensive Care Patients to Investigate the Clinical Effect of Repetitive Orally Inhaled Doses of AP301 on Alveolar Liquid Clearance in Acute Lung Injury July 2012 August 2014
NCT01628523 Completed Mechanical Ventilation in the Emergency Department: A Prospective Cross-Sectional Study July 2012 March 2014
NCT01659307 Completed Phase 2 The Effect of Aspirin on REducing iNflammation in Human in Vivo Model of Acute Lung Injury September 2012 September 9, 2022
NCT01883869 Completed Phase 1 Targeting Platelet-Leukocyte Aggregates in Pneumonia With Ticagrelor June 2013 June 2016
NCT01922557 Completed Thoracic Fluid Content and Acute Lung Injury January 2011 June 2012
NCT02083393 Completed Changes of Dendritic Cells in Acute Lung Injury June 2011 December 2014
NCT02106975 Completed Phase 2 Vitamin C Infusion for Treatment in Sepsis Induced Acute Lung Injury April 2014 January 8, 2018
NCT02201446 Completed The Role of Circulating Soluble CD74 in Acute Lung Injury March 2014 April 2015
NCT02247700 Completed Observational Cohort Study of Distribution of Ventilation in Pediatrics Requiring Mechanical Ventilation by Electrical Impedance Tomography October 1, 2014 November 4, 2018
NCT02320539 Completed MicroRNA Diagnostics in Subarachnoid Hemorrhage 2 November 2014 May 2015
NCT02475694 Completed Acute Lung Injury After Cardiac Surgery: Pathogenesis September 2008 March 2009
NCT02613377 Completed Transfusion-related Acute Lung Injury: a Prospective Cohort Study in Critically Ill Children January 2016 December 2021
NCT02734654 Completed N/A Limb RIPC in Patients Undergoing Lung Lobectomy. Study of Oxidative Lung Damage November 2007 January 2012
NCT02891837 Completed Phase 3 L-citrulline for Prevention of Sequelae of Acute Lung Injury in Pediatrics Undergoing Cardiopulmonary Bypass for Heart Defects August 2016 July 2019
NCT03315702 Completed Effect of Mechanical Ventilation on Plasma Concentration Level of R-spondin Proteins September 22, 2017 October 31, 2017
NCT03317431 Completed the Effect of Dopamine on Mechanical Ventilation Induced Lung Injury March 20, 2017 December 1, 2017
NCT03328117 Completed Phase 1 A Study to Investigate the Effects of Imatinib on Pulmonary Vascular Dysfunction in a Human Model of Lung Injury November 13, 2017 March 5, 2018
NCT03654352 Completed The ASTERS Study: Assessing the Role of Sphingolipids in AcuTE Respiratory Distress Syndrome (ARDS) April 17, 2019 March 12, 2021
NCT03764319 Completed N/A Low Frequency, Ultra-low Tidal Volume Ventilation in Patients With ARDS and ECMO November 6, 2018 August 1, 2021
NCT04247477 Completed N/A Comparison of Different PEEP Titration Strategies Using Electrical Impedance Tomography in Patients With ARDS September 22, 2020 April 8, 2021
NCT04311697 Completed Phase 2/Phase 3 Intravenous Aviptadil for Critical COVID-19 With Respiratory Failure May 15, 2020 February 22, 2021
NCT04412057 Completed Phase 2 Clinical Trial to Evaluate CERC-002 in Adults With COVID-19 Pneumonia and Acute Lung Injury July 17, 2020 January 19, 2021
NCT04449081 Completed Knowledge, Attitude and Practice of Dental Students About COVID-19 April 25, 2020 June 20, 2020
NCT04541199 Completed N/A Driving Pressures in a Closed-loop and a Conventional Mechanical Ventilation Mode August 30, 2019 March 31, 2021
NCT04693403 Completed N/A Adult Respiratory Failure Intervention Study Africa March 13, 2023 January 16, 2024
NCT05611385 Completed Amphetamine Induced Adult Respiratory Distress Syndrome January 1, 2019 January 1, 2020
NCT05886998 Completed Phase 3 Nebulized Heparin for Prevention of Acute Lung Injury in Smoke Inhalation Injury November 1, 2021 September 30, 2023
NCT00234767 Completed Study of the Economics of Pulmonary Artery Catheter Use in Patients With Acute Respiratory Distress Syndrome (ARDS) September 2001
NCT00258518 Completed Respiratory Mechanics and Pleural Effusion November 2005 June 2011
NCT05752058 Not yet recruiting Risk Factors for Early Acute Lung Injury After Liver Transplantation in Children August 1, 2023 December 31, 2024
NCT06290310 Not yet recruiting Assessment of Patient-ventilator Asynchrony by Electric Impedance Tomography April 12, 2024 September 1, 2024
NCT04871893 Recruiting N/A Safety and Efficacy Evaluation of CO2 Removal in Combination With Continuous Veno-Venous Hemodialysis/Hemodiafiltration Therapy March 25, 2022 December 2024
NCT05704166 Recruiting Phase 2 PirfenidoneVsPlacebo as Prophylaxis Against Acute Radiation-induced Lung Injury Following HFRT in Breast Cancer Patients March 16, 2023 December 31, 2024
NCT05364385 Recruiting Phase 4 Intra-tracheal Instillation of Budesonide to Prevent Chronic Lung Disease December 2, 2019 December 2024
NCT05316727 Recruiting Electronic Nicotine Delivery Devices and Potential Progression to Acute Lung Injury November 15, 2021 December 2024
NCT05825534 Recruiting N/A Pressure Opening With Electrical Impedance Tomography June 23, 2023 May 2024
NCT02598648 Recruiting N/A Role and Molecular Mechanism of Farnesoid X Receptor(FXR) and RIPK3 in the Formation of Acute Respiratory Distress Syndrome in Neonates September 20, 2015 September 30, 2023
NCT04935697 Recruiting N/A Non-invasive Vagal Neurostimulation (nVNS) for Traumatic Brain Injury (TBI)-Induced Acute Respiratory Distress August 4, 2021 December 2025
NCT06248320 Recruiting N/A Sigh Ventilation on Postoperative Hypoxemia in Cardiac Surgery February 25, 2024 November 2024
NCT05058768 Recruiting Omics Sequencing of Exosomes in Body Fluids of Patients With Acute Lung Injury May 6, 2022 December 16, 2024
NCT03766204 Recruiting The Role of Circulating CircRNAs and MicroRNAs in Acute Lung Injury January 1, 2017 December 31, 2024
NCT05414370 Recruiting N/A Hyperoxia Induced Pulmonary Inflammation and Organ Injury: a Human in Vivo Model December 2, 2022 December 30, 2024
NCT01901354 Terminated N/A Acute Lung Injury Ventilator Evaluation (ALIVE) November 2013 October 2014
NCT00742482 Terminated Phase 3 Efficacy and Safety of 3 Doses of HL10 Given at Fixed Time Intervals Compared to Standard Therapy January 2003 June 2005
NCT01921101 Terminated N/A Intensive Nutrition in Acute Respiratory Distress Syndrome (ARDS): A Clinical Trial (INTACT) July 2009 June 2013
NCT02978885 Terminated Phase 2 Imaging of Peri-operative (periOP) Lung Injury June 11, 2018 February 5, 2020
NCT03212690 Terminated N/A Study of Renin-angiotensin System in Mechanically Ventilated Subjects June 11, 2018 July 8, 2019
NCT00750204 Terminated N/A Airway Pressure Release Ventilation in Acute Lung Injury July 2008 October 15, 2008
NCT04369469 Terminated Phase 3 Efficacy and Safety Study of IV Ravulizumab in Patients With COVID-19 Severe Pneumonia May 10, 2020 April 8, 2021
NCT04526912 Terminated Phase 1 Treatment and Prevention of Acute Lung Injury (ALI) in Patients With COVID-19 Infection August 28, 2020 May 19, 2021
NCT04389840 Terminated Phase 2/Phase 3 Dociparstat for the Treatment of Severe COVID-19 in Adults at High Risk of Respiratory Failure July 8, 2020 May 20, 2021
NCT01667666 Terminated Phase 1 Clinical Trial of Nebulized Hypertonic Saline to Attenuate Post-Traumatic Acute Lung Injury May 2012 November 6, 2018
NCT00603564 Terminated N/A Helmet Continuous Positive Airway Pressure Versus Oxygen Venturi in Acute Respiratory Failure in CAP: CAPOVeRSO January 2006 July 2008
NCT00979121 Terminated Phase 3 Statins for Acutely Injured Lungs From Sepsis January 2010 November 2013
NCT00221819 Terminated N/A Gases Humidification During Noninvasive Ventilation : Heat and Moisture Exchanger or Heated Humidifier ? June 2004 December 2004
NCT00263146 Terminated N/A Recruitment Maneuvers in ARDS: Effects on Respiratory Function and Inflammatory Markers. September 2005 January 2006
NCT01769053 Terminated N/A Variable Pressure Support Trial January 2013 January 2018
NCT01038531 Terminated N/A Biomarkers of Lung Injury With Low Tidal Volume Ventilation Compared With Airway Pressure Release Ventilation July 2010 September 2016
NCT04397510 Terminated Phase 4 Nebulized Heparin for the Treatment of COVID-19 Induced Lung Injury June 1, 2020 December 31, 2021
NCT01464853 Terminated Phase 3 Effect of Enteral Nutrition Support for Critically Ill Patients April 2010 May 2011
NCT05289570 Terminated Phase 2 Voxelotor for Improving Oxygen Saturation in Adults May 3, 2022 July 4, 2023
NCT01503723 Unknown status Biomarkers in Exhaled Breath Condensates in Acute Lung Injury: Early Detection and Outcome Predictors August 2011
NCT04331613 Unknown status Phase 1/Phase 2 Safety and Efficacy of CAStem for Severe COVID-19 Associated With/Without ARDS January 27, 2020 December 2020
NCT00343993 Unknown status Phase 1 Noninvasive Positive Pressure Ventilation for ALI/ARDS:a Multicentre Randomized Controlled Trial June 2006 December 2007
NCT01619280 Unknown status Phase 1 Safety Study of Nebulized Sodium Nitroprusside in Adult Acute Lung Injury May 2012 June 2013
NCT00429637 Unknown status Continuous Exhaled Breath Condensate pH in Mechanically Ventilated Patients December 2004 January 2009
NCT00562835 Unknown status Phase 2/Phase 3 Steroids in Patients With Early ARDS February 2008 February 2009
NCT00639990 Unknown status N/A Respiratory Mechanics in Brain Injured Patients June 2007 December 2008
NCT00759590 Unknown status Comparison of Two Methods to Estimate the Lung Recruitment September 2008
NCT01936545 Unknown status N/A Anesthetic Methods and Liver Transplantation May 2011 December 2015
NCT01992237 Unknown status Measuring Energy Expenditure in ECMO (Extracorporeal Membrane Oxygenation) Patients October 2013 June 2018
NCT02095444 Unknown status Phase 1/Phase 2 Using Human Menstrual Blood Cells to Treat Acute Lung Injury Caused by H7N9 Bird Flu Virus Infection March 2014 December 2016
NCT02175303 Unknown status Phase 1/Phase 2 A Pilot Study Using Placenta Derived Decidual Stromal Cells for Toxicity and Inflammation With Special Focus to the Allogeneic Hematopoietic Cell Transplantation Setting December 2013 December 2017
NCT04659460 Unknown status N/A RIC as an Adjunct Therapy for Severe COVID-19 Disease: a Prospective Randomized Pilot Study December 15, 2020 September 1, 2021
NCT02208700 Unknown status N/A Efficacy of Oxepa Enteral Feeding in LTAC (Long Term Acute Care Hospital) Patients on Chronic Ventilation- a Pilot Study January 2014
NCT02412800 Unknown status Risk Factors of Postoperative Acute Lung Injury Following Liver Transplantation April 2015 January 2016
NCT00995228 Unknown status Fluid Management in the Post-Anesthetic Care Unit (PACU) at Sourasky Medical Center March 2009 December 2010
NCT02444455 Unknown status Phase 1/Phase 2 Human Umbilical-Cord-Derived Mesenchymal Stem Cell Therapy in Acute Lung Injury May 2015 December 2017
NCT02468531 Unknown status N/A Xenon Against Postoperative Oxygen Impairment January 2015 December 2017
NCT04873479 Unknown status N/A Effect of S-ketamine Anesthetic on Inflammatory Response in Septic Patients Undergoing Abdominal Surgery May 10, 2021 October 30, 2023
NCT01107847 Unknown status N/A Regional Lung Opening and Closing Pressures in Patients With Acute Lung Injury
NCT01131598 Unknown status Acute Lung Injury in Children: Epidemiology and Natural History. PEDIATRIC ALIEN. January 2010 January 2011
NCT02693912 Unknown status Changes in Alveolar Macrophage Function During Acute Lung Injury September 2016 August 2018
NCT04940676 Unknown status Phase 2 Oral Administration or Nasal Feeding of Huzhangxiefei Decoction for Treatment in Sepsis Induced Acute Lung Injury March 10, 2021 December 31, 2022
NCT01186874 Unknown status Epidemiology Research on Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) in Adult ICU in Shanghai September 2010 November 2011
NCT02739438 Unknown status The Study of ELEctronic Cigarette Toxicity in a Human Model in Vivo Model of Inflammation and Vascular Dysfunction February 1, 2017 December 2019
NCT04951882 Unknown status Early Phase 1 Application of hUC-MSCs in Treating Acute Lung Injury: a Single Center Prospective Clinical Research June 9, 2021 December 31, 2022
NCT01212640 Unknown status GROUP FOR TRALI STUDY. SEMICYUC. October 2010 December 2010
NCT02948530 Unknown status Measurement of Lung Elastance and Transpulmonary Pressure Using Two Different Methods (Lungbarometry) October 2016 December 2018
NCT01304654 Unknown status ALI/ARDS in Oncologic Pediatric Patients January 2011
NCT01326208 Unknown status Phase 2 Strategies to Optimize Positive End-expiratory Pressure (PEEP) in Patients With Acute Lung Injury March 2011 June 2013
NCT03753022 Unknown status N/A Effects of PEEP on Parameters of Tissue Perfusion in Patients Post Cardiac Surgery January 2012 December 2019
NCT01391481 Unknown status Phase 2 Perfluorocarbon (PFC) Inhalation Treatment of Acute Lung Injury/Acute Respiratory Distress Syndrome August 2011 April 2015
NCT03937947 Unknown status Traumatic Brain Injury Associated Radiological DVT Incidence and Significance Study September 28, 2019 April 2023
NCT04133740 Unknown status Phase 4 Oxygenation Targets in Cardiac Surgery Patients - a Before-and-after Study October 1, 2018 July 31, 2020
NCT00793013 Withdrawn Phase 2 Airway Pressure Release Ventilation (APRV) Compared to ARDSnet Ventilation November 2, 2020 November 2, 2020
NCT01757899 Withdrawn Phase 2 Effects and Safety of Infusion of Low-Doses of Methylprednisolone in Early ALI and ARDS in Children January 2014 January 2016
NCT04574869 Withdrawn Phase 1 A Study of RLS-0071 in Patients With Acute Lung Injury Due to COVID-19 Pneumonia in Early Respiratory Failure January 2021 December 2022
NCT01195428 Withdrawn N/A Simvastatin Effect on the Incidence of Acute Lung Injury/Adult Respiratory Distress Syndrome (ALI/ARDS) October 2010 October 2011
NCT05862675 Withdrawn The Role and Mechanism of Immune Regulation in Acute Lung Injury in Children May 2, 2023 May 30, 2026
NCT01083355 Withdrawn Assessing Respiratory Variability During Mechanical Ventilation in Acute Lung Injury (ALI) March 2010 March 2016
NCT01048996 Withdrawn Genetic Variability and Biomarkers in Children With Acute Lung Injury October 2009 June 2013
NCT00961168 Withdrawn N/A Work of Breathing and Mechanical Ventilation in Acute Lung Injury September 2009 September 2013
NCT00813371 Withdrawn N/A Airway Pressure Release Ventilation as a Preventative Strategy December 2008 December 2011
MeSH unique ID (MeSH (Medical Subject Headings))
D055371