Malaria, Falciparum
Information
- Disease name
- Malaria, Falciparum
- Disease ID
- Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT02084602 | Completed | Phase 4 | Assessment of Artesunate/Mefloquine in the Peruvian Amazon | June 18, 2014 | April 13, 2016 |
| NCT00082576 | Completed | Phase 2/Phase 3 | Azithromycin Plus Chloroquine Versus Mefloquine for the Treatment of Uncomplicated Malaria in Africa | June 2004 | May 2006 |
| NCT00084227 | Completed | Phase 2/Phase 3 | Azithromycin Plus Chloroquine Versus Atovaquone-Proguanil For The Treatment Of Uncomplicated Plasmodium Falciparum Malaria In South America | July 2004 | July 2005 |
| NCT02014727 | Completed | Phase 1 | Safety and Immunogenicity of Recombinant Pichia Pastoris AMA1-DiCo Candidate Malaria Vaccine With GLA-SE and Alhydrogel ® as Adjuvant in Healthy Malaria Non-Exposed European and Malaria Exposed African Adults | January 2014 | July 2015 |
| NCT02325180 | Completed | Phase 4 | Artemisinin-based Combination Therapy for Treatment of Plasmodium Falciparum Malaria in North Sumatera, Indonesia | January 2015 | June 2015 |
| NCT02329301 | Completed | N/A | Mass Drug Administration With Dihydroartemisinin + Piperaquine for Reducing Malaria in Southern Zambia | September 2014 | August 2020 |
| NCT02389439 | Completed | Phase 2 | Efficacy and Safety of Pyronaridine-artesunate for the Treatment in Uncomplicated Falciparum Malaria | March 1, 2015 | June 1, 2016 |
| NCT02434952 | Completed | Phase 4 | Safety and Tolerability of Low Dose Primaquine | October 2014 | |
| NCT02448745 | Completed | N/A | Liberia Insecticide Treated Durable Wall Linings Study: Protocol for a Cluster Randomised Trial (DL) | March 1, 2014 | April 1, 2017 |
| NCT02453308 | Completed | Phase 2/Phase 3 | A Study by the Tracking Resistance to Artemisinin Collaboration (TRAC) | August 2015 | March 2018 |
| NCT02637128 | Completed | Phase 4 | In Vivo Efficacy of Artemether-Lumefantrine and Artesunate-Amodiaquine for Uncomplicated P. Falciparum Malaria | March 2014 | July 2014 |
| NCT02737007 | Completed | Phase 1 | A Microdose Study in Healthy Subjects to Describe Intravenous Pharmacokinetics of GSK3191607 | April 18, 2016 | May 12, 2016 |
| NCT02851108 | Completed | Phase 2 | Methylene Blue Against Falciparum Malaria in Burkina Faso | October 2016 | February 2017 |
| NCT03355664 | Completed | Phase 3 | Study to Compare the Triple ACT AL+AQ With the ACT AL in Cambodia and Vietnam | March 19, 2018 | March 4, 2020 |
| NCT04609098 | Completed | Phase 2 | Single Low Dose Tafenoquine to Reduce P. Falciparum Transmission in Mali (NECTAR2) | October 29, 2020 | December 23, 2020 |
| NCT04709692 | Completed | Phase 2 | Efficacy of SJ733 in Adults With Uncomplicated Plasmodium Falciparum or Vivax Malaria | April 14, 2021 | April 15, 2022 |
| NCT00126906 | Completed | N/A | Prevention of Malaria During Pregnancy Using Intermittent Preventive Treatment With Sulfadoxine-Pyrimethamine: Malawi | October 2002 | March 2005 |
| NCT00137514 | Completed | Phase 4 | Chloroquine and Amodiaquine for Treatment of Malaria in Children | March 2001 | May 2004 |
| NCT00137553 | Completed | Phase 4 | The Efficacy of Re-treatment With Sulfadoxine-pyrimethamine in Children | May 2001 | March 2004 |
| NCT00142207 | Completed | Phase 3 | Preventing Malaria During Pregnancy in Epidemic-prone Areas. | January 2004 | January 2007 |
| NCT00142246 | Completed | Phase 3 | Study of the Impact of Intermittent Preventive Treatment in Schools on Malaria, Anaemia and Education. | January 2005 | April 2006 |
| NCT00147368 | Completed | Phase 1/Phase 2 | Arginine Malaria Trial: Study of Adjunctive Arginine in Falciparum Malaria | February 2005 | December 2007 |
| NCT00157885 | Completed | N/A | A Randomised Trial of Artekin and Artesunate & Amodiaquine for Uncomplicated Malaria in Timika, Papua, Indonesia. | July 2005 | December 2005 |
| NCT00164359 | Completed | Phase 4 | Amodiaquine Plus Artesunate Versus Lapdap Plus Artesunate in the Treatment of Uncomplicated P. Falciparum Malaria in Malawi | April 2005 | September 2005 |
| NCT00164710 | Completed | Phase 4 | Assessing the Efficacy of Four Drug Combinations as the Next First-line Therapy for Uncomplicated Malaria in Malawi | April 2005 | September 2005 |
| NCT00223990 | Completed | Phase 2 | Double-blind, Randomized, Controlled Study of Safety, Immunogenicity and Efficacy of a Candidate Malaria Vaccine | April 8, 2005 | June 2007 |
| NCT00344006 | Completed | Phase 3 | Chlorproguanil-Dapsone-Artesunate Versus COARTEM For Uncomplicated Malaria | June 2006 | August 2007 |
| NCT00371735 | Completed | Phase 3 | Chlorproguanil-Dapsone-Artesunate (CDA) Versus Chlorproguanil-Dapsone (LAPDAP) For Uncomplicated Malaria | April 2006 | May 2007 |
| NCT00374998 | Completed | Phase 1 | Safety and Immunogenicity Study of the Malaria Vaccines FP9 PP and MVA PP | April 2006 | January 2007 |
| NCT00375128 | Completed | Phase 1/Phase 2 | Sporozoite Challenge of Polyprotein Vaccinees | September 2006 | April 2007 |
| NCT00408668 | Completed | Phase 1/Phase 2 | Efficacy of Combined PEV3A Virosomal Vaccine and FP9-MVA ME-TRAP Prime Boost Regimen | August 2005 | February 2006 |
| NCT00426439 | Completed | Phase 4 | Chloroquine and Coartem for Treatment of Symptomatic Children With Plasmodium Falciparum in Guinea Bissau | December 2006 | November 2008 |
| NCT00479206 | Completed | N/A | Artemisinin Resistance in Cambodia | October 2006 | February 2007 |
| NCT00509015 | Completed | N/A | Mass-Drug Administration to Reduce Malaria Transmission | February 2008 | August 2008 |
| NCT00529867 | Completed | Phase 4 | Randomised Efficacy Study of Two Artemether-Lumefantrine Oral Formulations for the Treatment of Uncomplicated P. Falciparum Malaria | May 2007 | December 2007 |
| NCT00677833 | Completed | Phase 2/Phase 3 | Azithromycin Plus Chloroquine Versus Artemether-Lumefantrine For The Treatment Of Uncomplicated P. Falciparum Malaria In Children In Africa | June 2008 | September 2010 |
| NCT00885287 | Completed | Phase 4 | Interactions Between Artemether-lumefantrine and Antiretrovirals in HIV-patients With Uncomplicated Malaria in Tanzania | July 2009 | January 2013 |
| NCT00951106 | Completed | N/A | Therapeutic Efficacy Study of Pyrimethamine/Sulfdoxine (Fansidar®) for the Treatment of Uncomplicated Falciparum Malaria in the Peruvian Amazon | January 1998 | August 2009 |
| NCT01019408 | Completed | Phase 4 | Extended-dose Chloroquine (ECQ) for Resistant Falciparum Malaria Among Afghan Refugees in Pakistan | November 1993 | January 1995 |
| NCT01103830 | Completed | Phase 1 | Safety Study on the Effect of Eurartesim™ on QT/QTc Interval Compared to Riamet in Healthy Volunteers | February 2010 | December 2010 |
| NCT01108939 | Completed | Early Phase 1 | Study of Iron Absorption and Utilization in Asymptomatic Malaria | February 2009 | April 2010 |
| NCT01160562 | Completed | Pilot Study to Estimate the Burden and Distribution of Plasmodium Falciparum Malaria in Kalifabougou, Mali in Preparation for a Prospective Cohort Study of Naturally-Acquired Malaria Immunity | June 23, 2010 | January 23, 2013 | |
| NCT01163877 | Completed | N/A | Iron Absorption and Utilization in Adolescents Infected With Malaria Parasites, Hookworms or Schistosoma | April 2010 | September 2013 |
| NCT01213966 | Completed | Phase 2 | Efficacy, Tolerability, PK of OZ439 in Adults With Acute, Uncomplicated P.Falciparum or Vivax Malaria Mono-infection | October 2010 | May 2012 |
| NCT01222949 | Completed | Phase 1 | A Pharmacokinetic (PK) Trial in Healthy Asian and Caucasian Volunteers Investigating the PK Profile of Eurartesim™ | February 2010 | August 2010 |
| NCT01222962 | Completed | Phase 1 | Food Interaction Study on the Pharmacokinetics of Eurartesim™ (DHA and PQP)in Healthy Male Adult Volunteers | March 2010 | June 2010 |
| NCT01325974 | Completed | Time to Become Negative of Three Rapid Diagnostic Tests for Malaria | September 2011 | May 2013 | |
| NCT01326754 | Completed | N/A | Efficacy of Artemether-lumefantrine, Artesunate-amodiaquine and Dihydroartemisinin-piperaquine for the Treatment of Uncomplicated Plasmodium Falciparum Malaria in Malawi | August 2011 | June 2012 |
| NCT01556945 | Completed | Phase 1/Phase 2 | Safety and Preliminary Efficacy of the Malaria Vaccine Candidates Falciparum Merozoite Protein-1 (FMP1) and SmithKlineBeecham (SKBB) Candidate Malaria Vaccine RTS,S | April 2001 | |
| NCT01567423 | Completed | N/A | Efficacy Study of Amodiaquine-Artesunate and Artemether-Lumefantrine for the Treatment of Uncomplicated Malaria | April 2008 | April 2009 |
| NCT01660854 | Completed | N/A | Re-exposure of Human Volunteers to a Heterologous Strain of P. Falciparum Sporozoites | July 2012 | January 2013 |
| NCT01829737 | Completed | Malaria Transmission Studies in Mali | March 20, 2013 | January 20, 2015 | |
| NCT01930331 | Completed | Phase 4 | Safety, Tolerability, Pharmacokinetics and Efficacy of ARCO | January 7, 2014 | June 1, 2015 |
| NCT05385471 | Recruiting | Early Phase 1 | A Phase Ia Clinical Trial to Assess the Safety and Immunogenicity of the Blood-stage Malaria Candidate Vaccines RH5.1 in Matrix-M and R78C in Matrix-M in Healthy UK Adults | January 13, 2023 | July 31, 2024 |
| NCT06171113 | Recruiting | Phase 1 | A Study to Investigate the Safety of GSK4024484 in Healthy Adult Participants | December 12, 2023 | August 14, 2025 |
| NCT04839900 | Recruiting | N/A | Proactive Community Case Management for Malaria in Zambia | April 15, 2021 | December 30, 2023 |
| NCT00084240 | Terminated | Phase 2/Phase 3 | Azithromycin Plus Chloroquine Versus Sulfadoxine-Pyrimethamine Plus Chloroquine For The Treatment Of Uncomplicated, Symptomatic Falciparum Malaria In Southeast Asia | March 2004 | April 2005 |
| NCT00082563 | Terminated | Phase 2 | Azithromycin in Combination With Chloroquine Versus Chloroquine in the Eradication of Asymptomatic Plasmodium Falciparum | August 2004 | November 2004 |
| NCT00374205 | Terminated | Phase 4 | Randomized Trial on Effectiveness of ACTs in Ghana | September 2006 | October 2007 |
| NCT01442168 | Terminated | Phase 1/Phase 2 | Sevuparin/DF02 as an Adjunctive Therapy in Subjects Affected With Uncomplicated Falciparum Malaria | September 2011 | January 2014 |
| NCT02281344 | Terminated | Phase 1 | MMV390048 Against Early Plasmodium Falciparum Blood Stage Infection in Healthy Participants | October 2014 | December 19, 2014 |
| NCT01944189 | Unknown status | Phase 4 | Artemether/ Lumefantrine: A Study of the Effect of Local Food on Pharmacokinetics and Population Pharmacokinetics | September 2013 | March 2015 |
| NCT01713517 | Unknown status | Phase 4 | Impact of Insecticide Resistance on Vector Control | April 2011 | October 2014 |
| NCT00152204 | Unknown status | Phase 3 | The Community Effectiveness of IPTi in Southern Tanzania | March 2005 | December 2008 |
| NCT01204411 | Withdrawn | Phase 4 | Efficacy of Artesunate-amodiaquine (AS-AQ) in Children With Malaria and Severe Acute Malnutrition, Madaoua, Niger 2010 | ||
| NCT01783340 | Withdrawn | Phase 1/Phase 2 | Immunization With Plasmodium Falciparum Sporozoites Under Chloroquine or Chloroquine/Azithromycin Prophylaxis | April 2013 | April 2014 |
- MeSH unique ID (MeSH (Medical Subject Headings))
- D016778