Iron Overload

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Information
Disease name
Iron Overload
Disease ID
Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT00907283 Active, not recruiting Phase 2 Ferrochelating Treatment in Patients Affected by Neurodegeneration With Brain Iron Accumulation (NBIA) November 2008 December 2024
NCT04198545 Active, not recruiting Ethnic Differences in Iron Absorption (FeGenes) August 1, 2019 March 31, 2025
NCT00293098 Approved for marketing Compassionate Use of Deferiprone for Patients With Thalassemia and Iron-Induced Heart Disease March 2006
NCT00001455 Completed Iron Overload in African Americans June 1995 June 2000
NCT00004982 Completed Phase 1 Combination Iron Chelation Therapy December 1998 November 2002
NCT00005541 Completed Hemochromatosis and Iron Overload Screening Study (HEIRS) January 2000 January 2006
NCT00110266 Completed Phase 2 Study of Deferasirox for Treatment of Transfusional Iron Overload in Myelodysplastic Patients July 25, 2005 March 28, 2008
NCT00110617 Completed Phase 2 Study of Deferasirox Relative to Subcutaneous Deferoxamine in Sickle Cell Disease Patients May 2005 April 2008
NCT00117507 Completed Phase 4 Study for the Treatment of Transfusional Iron Overload in Myelodysplastic Patients September 2005 January 2008
NCT00138684 Completed Phase 2 Cytochrome P450 2E1 and Iron Overload September 2003 February 2006
NCT00171301 Completed Phase 4 Extension Study of the Efficacy and Safety of Deferasirox Treatment in Beta-thalassemia Patients With Transfusional Hemosiderosis (Study Amended to 2-year Duration) June 2005 May 2008
NCT00395629 Completed Phase 1/Phase 2 Safety and Efficacy of Deferasirox (ICL670) in Patients With Iron Overload Resulting From Hereditary Hemochromatosis August 2006 March 2009
NCT00401336 Completed N/A Quantification of Liver Iron Overload and Steatosis Using Magnetic Resonance Imaging November 2006 March 2013
NCT00447694 Completed Phase 2 Cardiac T2* in Beta-thalassemia Patients on Deferasirox Treatment February 2006 November 2009
NCT00512226 Completed N/A Iron Overload Assesment in Sickle Cell Anemia and Sickle Cell Thalassemia September 2007 December 2010
NCT00529152 Completed Phase 3 Safety and Efficacy of Ferriprox™ (Deferiprone) Oral Solution in Iron Overloaded Pediatric Patients August 2007 July 2008
NCT00629291 Completed MRI Evaluation of Iron Overload in the Heart, Liver and Pancreas in Patients Receiving Multiple Blood Transfusions. January 2008 May 2010
NCT00000588 Completed Phase 2 Chelation Therapy of Iron Overload With Pyridoxal Isonicotinoyl Hydrazone June 5, 1989 March 31, 1995
NCT00689182 Completed Phase 2 Safety and Efficacy of Iron Reduction by Phlebotomy May 2007 December 2012
NCT00712738 Completed Phase 1 Oral Nifedipine to Treat Iron Overload June 20, 2008 September 22, 2010
NCT00800761 Completed Phase 4 Intensive Combined Chelation Therapy for Iron-Induced Cardiac Disease in Patients With Thalassemia Major December 2001 June 2006
NCT00806715 Completed Iron Overload in Stem Cell Transplant Recipients February 2007 October 2010
NCT00901199 Completed Phase 2 Combined Chelation Therapy in Patients With Transfusion Dependent Thalassemia and Iron Overload September 2007 October 2012
NCT00654589 Completed Phase 4 Efficacy and Safety of Oral Deferasirox (20 mg/kg/d) in Pts 3 to 6 Months After Allogeneic Hematopoietic Cell Transplantation Who Present With Iron Overload February 2008 January 2012
NCT00000595 Completed Phase 2 Evaluation of Subcutaneous Desferrioxamine as Treatment for Transfusional Hemochromatosis January 1978 September 1994
NCT00000623 Completed Thalassemia (Cooley's Anemia) Clinical Research Network (TCRN) July 2000 July 2006
NCT01034072 Completed Iron Overload in Pediatric Oncology Patients December 2009 January 2012
NCT01045525 Completed Phase 3 Phlebotomy and Lifestyle and Diet Advices vs Lifestyle and Diet Advices Only in Patients With Dysmetabolic Liversiderosis January 2010 December 2015
NCT01047098 Completed N/A Effects of Taking Prenatal Vitamin-mineral Supplements During Lactation on Iron Status and Markers of Oxidation October 2008 April 2010
NCT01335035 Completed Phase 4 Open-Label Single-Arm Pilot Study in Adult Allogeneic Hematopoietic Stem Cell Transplant Recipients With Transfusional Iron Overload December 2008
NCT01369719 Completed N/A Efficacy and Safety of Desferal Versus Osveral in Transfusional Iron Overload February 2010 May 2011
NCT01376622 Completed Changes in Pituitary Iron and Volume With Deferasirox November 2008 July 1, 2011
NCT01395199 Completed Phase 3 Amlodipine in the Prevention and Treatment of Iron Overload in Patients With Thalassemia Major August 2012 February 2015
NCT01516853 Completed Non-invasive Quantification of Liver Iron With MRI January 2012 June 2015
NCT01546415 Completed Phase 4 Safety and Efficacy of Desferasirox in Chinese Patients With Iron Overload and Aplastic Anemia October 2011 November 2013
NCT01572818 Completed N/A Effects of Phlebotomy on Insulin Sensitivity in Insulin Resistance-associated Hepatic Iron Overload Patients October 2010 October 2015
NCT01572922 Completed N/A Massive Iron Deposit Assessment June 11, 2012 February 28, 2018
NCT01874405 Completed Retrospective Evaluation of Adult and Pediatric Transfusion-dependent Patients Treated With Deferasirox Therapy March 2003 October 2012
NCT01905774 Completed Renal Function Among Thalassemia Patients Treated by a Oral Chelator Deferasirox March 2011 August 2015
NCT02155114 Completed Iron Homoeostasis in Inflammation April 2014
NCT02164253 Completed Phase 2 Focal Accumulation of Iron in Cerebral Regions in Early ALS (Amyotrophic Lateral Sclerosis) Patients September 2013 December 2016
NCT02425956 Completed N/A Non-invasive Quantification of Liver Iron With MRI April 2015 June 30, 2016
NCT02527330 Completed Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR Imaging January 2014 December 2016
NCT02880033 Completed N/A Oxidative Stress and Apoptosis of Energy Metabolism by Deferiprone From the Circulating Lymphocytes February 2011 March 2020
NCT03372083 Completed Phase 4 Safety Study of Crushed Deferasirox Film Coated Tablets in Pediatric Patients With Transfusional Hemosiderosis January 16, 2018 December 5, 2019
NCT03591575 Completed Phase 4 Safety and Efficacy of Early Treatment With Deferiprone in Infants and Young Children November 9, 2018 September 29, 2020
NCT03990181 Completed N/A Inhibiting Dietary Iron Absorption in Subjects With Hereditary Hemochromatosis by a Natural Polyphenol Supplement September 20, 2019 August 15, 2020
NCT04018300 Completed N/A Iron Supplementation and Side Effects January 8, 2018 April 18, 2018
NCT04292314 Completed Phase 2/Phase 3 Hydroxy Urea, Omega 3, Nigella Sativa,Honey on Oxidative Stress and Iron Chelation in Pediatric Major Thalassemia November 1, 2019 January 20, 2021
NCT04515680 Completed Endocrine Function During Deferasirox Therapy November 2, 2016 January 30, 2019
NCT04614779 Completed Phase 2 Long-term Clinical Study of CN128 in Thalassemia Patients September 30, 2020 August 18, 2022
NCT04631718 Completed MRI QSM Imaging for Iron Overload January 18, 2022 April 29, 2024
NCT02025543 Enrolling by invitation Confounder-Corrected Quantitative MRI Biomarker of Hepatic Iron Content August 12, 2015 September 2024
NCT05294471 Recruiting Fully Automated High-Throughput Quantitative MRI of the Liver October 16, 2023 September 2026
NCT06146608 Recruiting Heme and Non-heme Iron Intakes, Gut Microbiota, and Influence on Host Iron Absorption January 15, 2023 January 14, 2026
NCT04423237 Recruiting Risk Factors and Measures to Prevent Liver and Pancreas Complications in Pediatric Patients After HSCT September 30, 2020 December 31, 2024
NCT05355766 Recruiting Phase 2 Long-term Clinical Study of CN128 in Thalassemia With Sever Liver Iron Overloaded Patients June 2, 2022 December 31, 2024
NCT06137079 Recruiting "Iron Overload and Endocrinological Diseases" June 20, 2013 December 31, 2025
NCT04741542 Suspended Phase 1 Safety of SP-420 in the Treatment of Transfusional Iron Overload March 9, 2021 August 2025
NCT00602446 Terminated Phase 2 Deferasirox in Treating Patients With Iron Overload After Undergoing a Donor Stem Cell Transplant August 2007 December 2009
NCT03777904 Terminated The Iron Content of Ferritin in Serum and Urine of Children With High Serum Ferritin Levels February 21, 2019 December 10, 2019
NCT02041299 Terminated Phase 4 Efficacy and Safety of Ferriprox® in Patients With Sickle Cell Disease or Other Anemias April 17, 2014 June 18, 2019
NCT02274233 Terminated Phase 1 Safety and Pharmacokinetic Study of Escalating Doses of SP-420, an Iron Chelator, in Patients With β-Thalassemia October 2014 September 2015
NCT01159067 Terminated Phase 2 Deferasirox for Treating Patients Who Have Undergone Allogeneic Stem Cell Transplant and Have Iron Overload July 2010 August 9, 2011
NCT02443545 Terminated Phase 4 Long-term Safety and Efficacy of Ferriprox® in Iron Overloaded Patients With Sickle Cell Disease or Other Anemias May 21, 2015 August 21, 2019
NCT01342705 Terminated Phase 3 Phlebotomy and Risk of Hepatocellular Carcinoma in Patients With Compensated Alcoholic Cirrhosis May 2011 June 2014
NCT05326503 Unknown status N/A Inhibitory Effect of a Polyphenol Supplement on Dietary Iron Absorption in Adults With Thalassemia May 1, 2022 December 31, 2022
NCT00980421 Unknown status Phase 3 Safety of Various Mode of Delivery of Iron Supplement on Iron Toxicity Markers in Preschool Children October 2009 August 2010
NCT00999349 Unknown status Phase 2/Phase 3 Therapeutic Effects of Silymarin in Patients With B-thalassemia Major March 2009
NCT02474420 Unknown status N/A Amlodipine as Adjuvant Treatment to Iron Chelation for Prevention of Cardiac Iron Overload in Thalassemia Patients June 2015 June 2018
NCT01121094 Unknown status Fetal Parenchymatic Evaluation (Liver, Spleen) Using T2* Sequences June 2010 June 2012
NCT01169961 Unknown status Assessment of Iron Deposition in Major Organs of Hemodialysis Patients February 2010 August 2010
NCT02833493 Unknown status Study of MRI Monitoring in Patients With Aplastic Anemia and Low or Int-1 Risk of MDS Complicated With Iron Overload September 2016 October 2019
NCT01443195 Unknown status N/A Iron Metabolism in Small Pre Term Newborns October 2011 December 31, 2020
NCT04835285 Unknown status N/A MRI T2* Mapping of Myocardium, Liver, Pancreas and Pituitary Gland January 21, 2020 January 21, 2023
NCT00378469 Unknown status N/A Study of the Effects of Muscular Activity on Iron Metabolism September 2006
NCT03801889 Withdrawn Phase 2 SP-420 in Subjects With Transfusion-dependent Beta-Thalassemia or Other Rare Anemias August 2020 January 2023
NCT03800446 Withdrawn N/A Validation of a Point-of-care Device Measuring Ferritin With Capillary Blood September 2019 June 2020
NCT03141398 Withdrawn Comparing CGM and OGTT in Relation to Iron Overload Detected by Pancreas T2* MRI in High-Risk Hematology Group August 2017 December 2018
NCT01927913 Withdrawn Phase 2 Treatment of Iron Overload Requiring Chelation Therapy November 20, 2014 October 30, 2015
MeSH unique ID (MeSH (Medical Subject Headings))
D019190