bronchiolitis obliterans
Information
- Disease name
- bronchiolitis obliterans
- Disease ID
- DOID:2799
- Description
- "A obstructive lung disease involving obstruction of the bronchioles due to inflammation and fibrosis which occurs as a complication of various lung conditions or physiological insults." [url:http\://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=bronchiolitis%20obliterans]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT04239989 | Active, not recruiting | Phase 1 | Itacitinib for the Treatment of Bronchiolitis Obliterans Syndrome After Donor Hematopoietic Cell Transplant | April 8, 2021 | May 31, 2024 |
| NCT03656926 | Active, not recruiting | Phase 3 | Efficacy + Safety of Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Single Lung Transplant (BOSTON-2) | March 29, 2019 | October 9, 2024 |
| NCT03657342 | Active, not recruiting | Phase 3 | Efficacy + Safety of Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Single Lung Transplant (BOSTON-1) | April 2, 2019 | November 2024 |
| NCT00367419 | Completed | Phase 4 | Use of Erythromycin in Mustard-Induced Bronchiolitis | ||
| NCT00381147 | Completed | Phase 3 | Use of Clarithromycin in Mustard-Induced Bronchiolitis | ||
| NCT02458274 | Completed | Microparticles and Bronchiolitis Obliterans Syndrome | July 2014 | July 2020 | |
| NCT00029328 | Completed | Phase 1/Phase 2 | Etanercept for Non-Infectious Lung Injury Following Bone Marrow Transplantation | September 2001 | September 2003 |
| NCT00141726 | Completed | Phase 2 | Study of Enbrel (Etanercept) for the Treatment Sub-Acute Pulmonary Dysfunction After Allogeneic Stem Cell Transplant | October 2003 | February 2009 |
| NCT00743171 | Completed | Long-Term Study On Home Spirometry After Lung Transplantation | January 2000 | December 2007 | |
| NCT00861900 | Completed | Immune Mechanisms of Rejection in Human Lung Allografts | January 1998 | July 2017 | |
| NCT00891865 | Completed | Viral Triggers in Pediatric Lung Transplantation | June 2009 | April 2015 | |
| NCT01175655 | Completed | Phase 1 | A Study to Evaluate the Potential of Mesenchymal Stromal Cells to Treat Obliterative Bronchiolitis After Lung Transplantation | February 2010 | July 2016 |
| NCT01206309 | Completed | Immune Mediated Disorders After Allogeneic Hematopoietic Cell Transplantation | March 2011 | October 2016 | |
| NCT01211509 | Completed | Phase 4 | Montelukast in Bronchiolitis Obliterans Syndrome | October 2010 | March 2015 |
| NCT01212406 | Completed | Phase 4 | Vitamin D in Bronchiolitis Obliterans Syndrome | October 2010 | August 2015 |
| NCT01273207 | Completed | Phase 2 | Extension Study (Extended Access) of Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment of Bronchiolitis Obliterans | March 2, 2012 | May 23, 2019 |
| NCT01287078 | Completed | Phase 2 | Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment of Bronchiolitis Obliterans Syndrome | January 29, 2011 | August 8, 2018 |
| NCT01307462 | Completed | Phase 2 | Targeted Therapy of Bronchiolitis Obliterans Syndrome | June 2011 | December 2015 |
| NCT01327248 | Completed | Clinical Status and Bronchial Inflammation in Patients With Bronchiolitis Obliterans | May 2011 | June 2012 | |
| NCT01429844 | Completed | Phase 3 | Tacrolimus Versus Cyclosporine for Immunosuppression After Lung Transplantation | January 2001 | August 2010 |
| NCT01560689 | Completed | Phase 2 | Inhaled BUDESONIDE/FORMOTEROL in Bronchiolitis Obliterans Following Stem Cell Transplantation | June 2008 | July 2012 |
| NCT01633385 | Completed | Bronchial Inflammation in Patients With Bronchiolithis Obliterans | April 2012 | December 2012 | |
| NCT01650545 | Completed | Phase 1/Phase 2 | Aerosol Liposomal Cyclosporine for Chronic Rejection in Lung Transplant Recipients | July 2012 | November 2019 |
| NCT02032381 | Completed | N/A | Prospective Study of Belated Pulmonary Complications Occurring in Children Treated With Allogeneic Hematopoietic Stem Cells. | January 2014 | March 30, 2020 |
| NCT02181712 | Completed | Phase 1 | Mesenchymal Stem Cell Therapy for Lung Rejection | July 2014 | August 12, 2021 |
| NCT02364674 | Completed | N/A | Transplant Optimization Using Functional Imaging | February 2015 | January 9, 2017 |
| NCT02441413 | Completed | N/A | Transplant Optimization Using Functional Imaging (TROFI) | September 2015 | November 8, 2016 |
| NCT00027235 | Completed | Popcorn Lung: the Discovery of a New Disease | |||
| NCT02495597 | Completed | LCI and Bronchial Inflammation in Patients With BO | April 2013 | December 2014 | |
| NCT02902471 | Completed | N/A | Forced Oscillations for Diagnosis Help in Bronchiolitis Obliterans Syndrome in Post Bone Marrow Transplantation | June 2011 | September 2015 |
| NCT03315741 | Completed | Phase 1 | The Safety and Tolerability of Pirfenidone for BOS After HCT | March 1, 2018 | April 27, 2022 |
| NCT03868904 | Completed | INSPIRE Continuation Post-Approval Study | June 30, 2019 | October 12, 2021 | |
| NCT05299567 | Completed | Phase 4 | Efficacy and Safety of Azithromycin in Patients With Bronchiolitis Obliterans | August 24, 2010 | July 21, 2011 |
| NCT00563251 | Completed | N/A | Effectiveness of Azithromycin Therapy in Improvement of Symptoms and Lung Function in Patients With Bronchiolitis Obliterans After Bone Marrow Transplantation | April 2005 | March 2007 |
| NCT00656058 | Completed | Phase 2 | Montelukast to Treat Bronchiolitis Obliterans | June 17, 2008 | February 22, 2018 |
| NCT00701922 | Completed | Surveillance Study of Viral Infections Following Lung Transplantation | October 2005 | December 2007 | |
| NCT04039347 | Enrolling by invitation | Phase 3 | Extension Trial on Efficacy / Safety of L-CsA + SoC in Treating BOS in Post Single or Double Lung Transplant (BOSTON-3) | March 12, 2020 | September 2024 |
| NCT04098445 | Recruiting | TRANSPIRE: Lung Injury in a Longitudinal Cohort of Pediatric HSCT Patients | September 8, 2021 | September 2036 | |
| NCT04080232 | Recruiting | N/A | Study of Pulmonary MRI for the Diagnosis of Bronchiolitis Obliterans Syndrome After Allogeneic Stem Cell Transplantation | February 6, 2020 | September 24, 2023 |
| NCT04604522 | Recruiting | Evaluating Clonogenic Epithelial Cell Populations in Patients With Bronchiolitis Obliterans Syndrome | August 27, 2020 | March 31, 2024 | |
| NCT06140901 | Recruiting | N/A | Bronchial Epithelium of Children With Post-infectious Bronchiolitis Obliterans | December 4, 2023 | November 2026 |
| NCT02657837 | Recruiting | Measures of Respiratory Health (MRH) | January 2016 | December 1, 2024 | |
| NCT05881538 | Recruiting | N/A | High Intensity Intervallic Training in Children With Bronchiolitis Obliterans | May 29, 2023 | September 2024 |
| NCT05922761 | Recruiting | Phase 2 | BElumosudil for Bronchiolitis Obliterans Prevention/Therapy (BEBOP) | May 31, 2024 | December 31, 2026 |
| NCT03603899 | Recruiting | Phase 1/Phase 2 | Hp129 Xenon Imaging and BOS in Lung Transplantation | September 9, 2020 | October 2027 |
| NCT00177918 | Recruiting | Prospective Evaluations of Infectious Complication in Lung Transplant Recipients | August 2006 | December 2025 | |
| NCT05932316 | Recruiting | N/A | Evaluating Bronchodilator Response in Patients With Bronchiectasis | May 20, 2023 | December 2024 |
| NCT01432080 | Terminated | Phase 2 | Steroids, Azithromycin, Montelukast, and Symbicort (SAMS) for Viral Respiratory Tract Infection Post Allotransplant | September 2011 | December 30, 2013 |
| NCT01439958 | Terminated | Phase 3 | Long-term Safety Follow-up Study in the Prevention of Bronchiolitis Obliterans Syndrome (BOS) | February 2012 | December 2014 |
| NCT00502554 | Terminated | N/A | Extracorporeal Photopheresis in Patients With Bronchiolitis Obliterans Syndrome (BOS) After Lung Transplantation | August 2007 | March 2010 |
| NCT01327625 | Terminated | N/A | Efficacy Study of Azithromycin-based Therapy for Bronchiolitis Obliterans | March 2011 | June 2013 |
| NCT01334892 | Terminated | Phase 2/Phase 3 | L-CsA in the Prevention of Bronchiolitis Obliterans Syndrome (BOS) in Lung Transplant (LT) Patients | December 2009 | December 2014 |
| NCT04655508 | Terminated | Phase 3 | Efficacy of Fluticasone Propionate Associated With Salmeterol Using Inhalation Chamber Versus Placebo to Improve the Respiratory Function in Children Over Six Years of Age Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation With a Decline of FEV1 ≥10% From Pre Transplantation | May 21, 2021 | September 27, 2023 |
| NCT02488304 | Terminated | Phase 2 | Prospective Study for Transplant Optimization Using Functional Imaging (TROFI) | July 2015 | December 15, 2017 |
| NCT01163786 | Terminated | Phase 2 | A Proposal to Test the Efficacy and Tolerability of Bortezomib in Pulmonary Chronic GVHD | October 7, 2010 | September 9, 2015 |
| NCT04029636 | Unknown status | Hyperpolarized 129Xe MRI for the Assessment of BOS With Late Onset LONIPC | August 2019 | November 2021 | |
| NCT00378677 | Unknown status | Early Phase 1 | Dry Powder Inhalation of Cyclosporine A in Lung Transplant Patients With Bronchiolitis Obliterans Syndrome | February 2007 | |
| NCT02543073 | Unknown status | Phase 1/Phase 2 | MSC for Treatment of Interstitial Lung Disease After Allo-HSCT | September 2014 | June 2018 |
| NCT00163696 | Unknown status | Multi Breath Nitrogen Washout (MBNW) as a Measure of Small Airway Function in Patients With Respiratory Disease | September 2004 | ||
| NCT02627833 | Unknown status | Lung Function, LCI, Bronchial Inflammation and Epigenetics of Patients With BO | October 2015 | ||
| NCT02109237 | Withdrawn | N/A | Sleep Disorders in Bronchiolitis Obliterans Syndrome 2&3 | May 2014 | May 2020 |
- Disase is a (Disease Ontology)
- DOID:3082
- Cross Reference ID (Disease Ontology)
- GARD:9551
- Cross Reference ID (Disease Ontology)
- MESH:D001989
- Cross Reference ID (Disease Ontology)
- NCI:C62580
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:40100001
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0006272
- Exact Synonym (Disease Ontology)
- Bronchiolitis exudativa
- Exact Synonym (Disease Ontology)
- Bronchiolitis fibrosa obliterans
- Exact Synonym (Disease Ontology)
- Obliterative bronchiolitis
- HPO Human Phenotype ID (Human Phenotype Ontology)
- HP:0011946
- MeSH unique ID (MeSH (Medical Subject Headings))
- D001989