Anemia, Sickle Cell
Information
- Disease name
- Anemia, Sickle Cell
- Disease ID
- Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT04170348 | Active, not recruiting | Phase 2 | Daily Vitamin D for Sickle-cell Respiratory Complications | September 15, 2020 | February 28, 2025 |
| NCT03249831 | Active, not recruiting | Phase 1 | A Blood Stem Cell Transplant for Sickle Cell Disease | January 4, 2019 | November 17, 2024 |
| NCT00000592 | Completed | Phase 3 | Stroke Prevention in Sickle Cell Anemia (STOP 1) | July 1994 | August 2000 |
| NCT00000602 | Completed | Phase 2 | Pediatric Hydroxyurea in Sickle Cell Anemia (PED HUG) | April 1994 | March 1997 |
| NCT00005277 | Completed | Cooperative Study of The Clinical Course of Sickle Cell Disease | September 1977 | December 2000 | |
| NCT00005300 | Completed | Investigation of Selected Patient Groups From The Cooperative Study of Sickle Cell Disease | October 1988 | June 1995 | |
| NCT00005326 | Completed | Cerebrovascular Involvement in Sickle Cell Disease - Comprehensive Sickle Cell Center | January 1988 | March 2004 | |
| NCT00005327 | Completed | Prevention of Cerebral Infarction in Sickle Cell Anemia - Comprehensive Sickle Cell Center | April 1993 | March 2003 | |
| NCT00005438 | Completed | Neuropsychological Studies of Children With Sickle Cell | February 1993 | January 1998 | |
| NCT00005467 | Completed | Indices of Severity and Prognosis for Sickle Cell Disease | January 1990 | December 1992 | |
| NCT00005703 | Completed | Hemostasis in Sickle Cell Disease--Infancy to Adulthood | July 1995 | July 1998 | |
| NCT00006182 | Completed | Phase 3 | Stroke Prevention in Sickle Cell Anemia (STOP 2) | July 2000 | February 2006 |
| NCT00006400 | Completed | Phase 3 | Hydroxyurea to Prevent Organ Damage in Children With Sickle Cell Anemia | August 2000 | September 2009 |
| NCT00029380 | Completed | Phase 2 | Cord Blood Transplantation for Sickle Cell Anemia and Thalassemia | January 1999 | August 2006 |
| NCT00029393 | Completed | Phase 2 | Induction of Stable Chimerism for Sickle Cell Anemia | August 2001 | July 2007 |
| NCT00029731 | Completed | Phase 2 | Arginine Treatment of Acute Chest Syndrome (Pneumonia) in Sickle Cell Disease Patients | August 2001 | July 2005 |
| NCT00000585 | Completed | Phase 3 | Penicillin Prophylaxis in Sickle Cell Disease (PROPS) | August 1983 | October 1994 |
| NCT00035763 | Completed | Pain in Sickle Cell Epidemiologic Study | October 2001 | August 2006 | |
| NCT00037388 | Completed | Pediatrics:Chlamydia, Sickle Cell Anemia and Stroke Risk - Ancillary to STOP II | July 2004 | June 2006 | |
| NCT00059293 | Completed | Transcranial Doppler (TCD) Ultrasound of Subjects Enrolled in BABY HUG - Ancillary to BABY HUG | September 2002 | July 2008 | |
| NCT00067080 | Completed | Phase 2 | Safety of ICL670 vs. Deferoxamine in Sickle Cell Disease Patients With Iron Overload Due to Blood Transfusions | May 2003 | |
| NCT00094887 | Completed | Phase 2 | Nitric Oxide Inhalation to Treat Sickle Cell Pain Crises | October 2004 | December 2008 |
| NCT04584528 | Completed | N/A | Implementing an Individualized Pain Plan (IPP) for ED Treatment of VOE's in Sickle Cell Disease | October 27, 2020 | October 1, 2022 |
| NCT04536792 | Completed | Phase 1 | A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AG-946 in Healthy Volunteers and in Participants With Sickle Cell Disease | July 10, 2020 | December 19, 2023 |
| NCT00143572 | Completed | Phase 1 | Use of Hydroxyurea and Magnesium Pidolate for Treatment of Sickle Cell Disease | November 2004 | January 2008 |
| NCT00246077 | Completed | Quality of Life of Children With Sickle Cell Disease Who Are Getting Chronic Transfusions With a Lifeport | October 2005 | December 2005 | |
| NCT04134299 | Completed | N/A | To Assess Safety, Tolerability and Physiological Effects on Structure and Function of AXA4010 in Subjects With Sickle Cell Disease | September 25, 2019 | January 11, 2021 |
| NCT00300235 | Completed | Priapism in Boys and Men With Sickle Cell Disease - Demographics, Characteristics and Prevalence | August 2005 | March 2008 | |
| NCT00313963 | Completed | Phase 3 | MAST - Magnesium for Sickle Cell Acute Crisis in Children | April 2006 | July 2013 |
| NCT00448370 | Completed | Role of Placenta Growth Factor in Sickle Acute Chest Syndrome | March 2007 | ||
| NCT00513617 | Completed | Phase 2 | Effectiveness of Arginine as a Treatment for Sickle Cell Anemia | June 2004 | January 2008 |
| NCT04011345 | Completed | N/A | Folic Acid Supplementation in Children With Sickle Cell Disease | November 23, 2020 | October 31, 2022 |
| NCT00528801 | Completed | Examining Cognitive Function and Brain Abnormalities in Adults With Sickle Cell Disease | December 2004 | May 2008 | |
| NCT03926819 | Completed | Phase 1 | A Study to Assess the Safety and Pharmacokinetics of HBI-002, an Oral Carbon Monoxide Therapeutic, in Healthy Volunteers | July 25, 2022 | April 26, 2023 |
| NCT03397017 | Completed | Transfusion Treatment in Patients With SCD | July 1, 2016 | June 30, 2022 | |
| NCT03380351 | Completed | Specifying Interventions From the Sickle Cell Disease Implementation Consortium (SCDIC) | August 26, 2019 | March 30, 2024 | |
| NCT00600665 | Completed | N/A | Effectiveness of a Computerized Tool (PAINRelieveIt) to Help Manage Pain Related to Sickle Cell Disease | February 2007 | June 2014 |
| NCT00850018 | Completed | Phase 1 | Examining Cognitive Function and Brain Abnormalities in Adults With Sickle Cell Disease - Pilot Intervention Study | December 2004 | December 2010 |
| NCT00860782 | Completed | N/A | Parent Educational Program for Children With Sickle Cell Disease | August 2008 | May 2016 |
| NCT00890396 | Completed | Long-Term Effects of Hydroxyurea in Children With Sickle Cell Anemia (The BABY HUG Follow-up Study) | September 2008 | December 2011 | |
| NCT03069430 | Completed | A Self-Management Intervention for Youth With Sickle Cell Disease and Their Families: Phase I | August 1, 2016 | March 31, 2017 | |
| NCT01054768 | Completed | Phase 2 | Antioxidant Therapy to Reduce Inflammation in Sickle Cell Disease | August 2009 | April 2013 |
| NCT01178099 | Completed | Phase 1 | An Assessment of Prasugrel on Healthy Adults and Sickle Cell Adults | July 2010 | January 2011 |
| NCT01356485 | Completed | Phase 1 | Safety Study of MP4CO in Adult Sickle Cell Patients | January 2012 | December 2012 |
| NCT03006718 | Completed | N/A | SCD-PROMIS: A Software Platform to Enhance Self-efficacy and Patient-provider Engagement for Patients With Sickle Cell Pain | November 2016 | September 2019 |
| NCT01482091 | Completed | Phase 4 | Intranasal Fentanyl for Initial Treatment of a Vaso-occlusive Crisis | December 2011 | |
| NCT01522547 | Completed | Phase 1 | Study to Determine the Maximum Tolerated Dose, Safety and Effectiveness of Pomalidomide for Patients With Sickle Cell Disease | August 1, 2007 | December 1, 2013 |
| NCT01547793 | Completed | Carbon Monoxide Levels and Sickle Cell Disease Severity | January 26, 2012 | November 4, 2015 | |
| NCT02857023 | Completed | N/A | Feasibility and Efficacy of a Home-based, Computerized Cognitive Training Program in Pediatric Sickle Cell Disease | October 2014 | August 2018 |
| NCT02022891 | Completed | Systematic Psychological and Medical Care for Children With SCD | January 2013 | May 2014 | |
| NCT02672540 | Completed | Phase 2 | A Study of SANGUINATE for the Treatment of Vaso-occlusive Crisis (VOC) in Adult Sickle Cell Disease Patients | July 2016 | May 31, 2017 |
| NCT02561312 | Completed | Comparison of Two Methods of Transfusion for Stroke Prevention in Sickle Cell | September 2015 | September 30, 2017 | |
| NCT02187003 | Completed | Phase 3 | Efficacy and Safety of Rivipansel (GMI-1070) in the Treatment of Vaso-Occlusive Crisis in Hospitalized Subjects With Sickle Cell Disease | June 17, 2015 | June 25, 2019 |
| NCT02497924 | Completed | Phase 1 | A Study of the Absorption, Metabolism, and Excretion of GBT440 in Healthy Male Subjects | June 2015 | July 2016 |
| NCT02394587 | Completed | N/A | MBSR for Pain Catastrophizing in SCD | April 2015 | January 2016 |
| NCT02411708 | Completed | Phase 2 | Study of SANGUINATE™ In the Treatment of Sickle Cell Disease Patients With Vaso-Occlusive Crisis | November 2016 | December 2017 |
| NCT00000586 | Completed | Phase 3 | Multicenter Study of Hydroxyurea in Patients With Sickle Cell Anemia (MSH) | January 1992 | June 1994 |
| NCT06290401 | Not yet recruiting | Phase 2 | A Socio-ecological Approach for Improving Self-management in Adolescents With SCD | November 30, 2024 | June 30, 2028 |
| NCT06144749 | Not yet recruiting | Phase 1/Phase 2 | A Safety, Efficacy, and Pharmacokinetic (PK) Study of HBI-002, an Oral Carbon Monoxide (CO) Therapeutic, in Subjects With Sickle Cell Disease (SCD) | May 1, 2024 | December 1, 2024 |
| NCT04406818 | Recruiting | N/A | Metabolic and Hemodynamic Reserve in Pediatric SCA | June 30, 2021 | March 31, 2026 |
| NCT06078696 | Recruiting | Phase 1/Phase 2 | Siplizumab for Sickle Cell Disease Transplant | September 28, 2023 | July 2029 |
| NCT05451940 | Recruiting | Phase 1/Phase 2 | Hydroxyurea and EPO in Sickle Cell Disease | May 25, 2023 | August 2025 |
| NCT05087303 | Recruiting | N/A | Telemedicine for Children With Sickle Cell Disease | November 23, 2022 | January 1, 2026 |
| NCT02286154 | Recruiting | N/A | Therapeutic Response Evaluation and Adherence Trial (TREAT) | October 2014 | October 2024 |
| NCT06250595 | Recruiting | European Rare Blood Disorders Platform (ENROL) | July 1, 2022 | July 2037 | |
| NCT04351698 | Recruiting | Phase 2/Phase 3 | SMILES: Study of Montelukast in Sickle Cell Disease | October 16, 2023 | September 30, 2024 |
| NCT03376893 | Recruiting | Epidemiology of Silent and Overt Strokes in Sickle Cell Disease | June 2, 2017 | December 31, 2026 | |
| NCT00529061 | Terminated | Establishing a Database of People With Sickle Cell Disease (Comprehensive Sickle Cell Centers Collaborative Data Project [C-Data]) | March 2005 | September 2008 | |
| NCT00528203 | Terminated | Establishing a Repository of Blood and DNA Samples From People With Sickle Cell Disease (Comprehensive Sickle Cell Centers Collaborative Genotype-Phenotype Database and Sample Repository) | August 2007 | September 2008 | |
| NCT04091737 | Terminated | Phase 1 | CSL200 Gene Therapy in Adults With Severe Sickle Cell Disease | October 2, 2019 | May 5, 2021 |
| NCT00131508 | Terminated | Phase 2 | Trial of Oral Glutamine in Patients With Sickle Cell Anemia | May 2004 | April 2009 |
| NCT02373241 | Terminated | Phase 2 | Preventing Sickle Cell Kidney Disease | April 2015 | July 2021 |
| NCT02186418 | Terminated | Phase 1/Phase 2 | Gene Transfer for Patients With Sickle Cell Disease | July 2014 | October 31, 2022 |
| NCT02636387 | Terminated | Desmopressin as a Therapy for Bedwetting in Children With Sickle Cell Disease | August 26, 2015 | October 27, 2018 | |
| NCT02065869 | Terminated | Phase 1/Phase 2 | Safety Study of Gene Modified Donor T-cells Following TCRαβ+ Depleted Stem Cell Transplant | April 2014 | September 7, 2021 |
| NCT00981370 | Terminated | Phase 3 | Clinical Importance of Treating Iron Overload in Sickle Cell Disease | April 2009 | December 2010 |
| NCT00840567 | Terminated | N/A | Skin and Blood Research Samples From Healthy Volunteers and Patients With Hematologic Diseases | February 2009 | October 2010 |
| NCT00530270 | Terminated | Phase 3 | Dexamethasone to Treat Acute Chest Syndrome in People With Sickle Cell Disease | December 2006 | November 2008 |
| NCT03733249 | Terminated | Phase 1/Phase 2 | Long Term Follow-up Study for Patients Enrolled on the BP-004 Clinical Study | January 2017 | April 14, 2023 |
| NCT04420585 | Terminated | Phase 4 | Desmopressin for Bedwetting in Children With SCD | July 7, 2020 | June 12, 2023 |
| NCT00122980 | Terminated | Phase 3 | Stroke With Transfusions Changing to Hydroxyurea | October 2006 | December 2010 |
| NCT00115336 | Terminated | Phase 4 | Ketorolac Versus Ibuprofen to Treat Painful Episodes of Sickle Cell Disease | January 2005 | December 2008 |
| NCT00034528 | Terminated | Phase 2 | Stem Cell Transplantation After Reduced-Dose Chemotherapy for Patients With Sickle Cell Disease or Thalassemia | September 2001 | November 2003 |
| NCT00599482 | Unknown status | Phase 1 | Far Infrared Radiation for Sickle Cell Pain Management | January 2008 | January 2009 |
| NCT03062501 | Unknown status | Phase 2 | Hydroxyurea in the Emergency Room to Lessen Pain in Sickle Cell Crisis | November 2016 | July 2017 |
| NCT02813629 | Unknown status | Phase 2 | tDCS Associated With Peripheral Electrical Stimulation for Pain Control in Individuals With Sickle Cell Disease | March 2016 | December 2022 |
| NCT02843347 | Unknown status | STRIDE Biorepository | March 13, 2017 | July 2023 | |
| NCT00276146 | Withdrawn | Phase 2 | Dipyridamole/Magnesium To Improve Sickle Cell Hydration | May 2005 | |
| NCT01419704 | Withdrawn | Phase 1/Phase 2 | Phase I/II Pilot Study of Mixed Chimerism to Treat Hemoglobinopathies | May 2011 | May 2016 |
| NCT01925001 | Withdrawn | Phase 2 | Phase 2 Study of MP4CO to Treat Vaso-occlusive Sickle Crisis | October 2013 | October 2015 |
- MeSH unique ID (MeSH (Medical Subject Headings))
- D000755