chronic granulomatous disease
Information
- Disease name
- chronic granulomatous disease
- Disease ID
- DOID:3265
- Description
- "A phagocyte bactericidal dysfunction characterized by an inability to resist repeated infectious diseases and a tendency to develop chronic inflammation. Life-threatening recurrent fungal and bacterial infections affecting the skin, lungs, liver, lymph nodes, and bones may occur along with swollen areas of inflamed tissues known as granulomas that can be widely distributed." [url:http\://en.wikipedia.org/wiki/Chronic_granulomatous_disease, url:https\://medlineplus.gov/genetics/condition/chronic-granulomatous-disease/, url:https\://rarediseases.org/rare-diseases/chronic-granulomatous-disease/, url:https\://www.ncbi.nlm.nih.gov/books/NBK99496/]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT03333486 | Active, not recruiting | Phase 2 | Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer | December 7, 2017 | August 28, 2024 |
| NCT02609932 | Completed | Phase 1 | Effect of IFN-γ on Innate Immune Cells | July 2016 | February 2019 |
| NCT00001476 | Completed | Phase 1 | Gene Therapy for Chronic Granulomatous Diseases - Long-term Follow-up | June 1, 1995 | December 13, 2010 |
| NCT00006417 | Completed | Phase 2 | Modified Stem Cell Transplantation Procedure for Treating Chronic Granulomatous Disease | October 2000 | November 2004 |
| NCT00023192 | Completed | Phase 3 | Treatment of Chronic Granulomatous Disease With Allogeneic Stem Cell Transplantation Versus Standard of Care | August 2001 | June 2004 |
| NCT03513328 | Completed | Phase 1/Phase 2 | Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation | June 15, 2018 | February 19, 2023 |
| NCT00001515 | Completed | Phase 1 | Diagnostic Effectiveness of Virtual Bronchoscopy | December 1995 | November 2001 |
| NCT03548818 | Completed | Role of Interferon-gamma 1-b (IFN-γ) on Cells of the Innate Immune System: Functional, Biochemical and Gene Expression Studies in Patients With Chronic Granulomatous Disease | May 16, 2018 | July 15, 2020 | |
| NCT00368446 | Completed | Genetic Disorders of Mucociliary Clearance in Nontuberculous Mycobacterial Lung Disease | October 17, 2006 | ||
| NCT00001765 | Completed | Phase 1 | Stem Cell Transplant Following Low-Intensity Chemotherapy to Treat Chronic Granulomatous Disease | April 1998 | February 2005 |
| NCT00578643 | Completed | Phase 2 | Matched Unrelated or Non-Genotype Identical Related Donor Transplantation For Chronic Granulomatous Disease | March 2004 | November 24, 2017 |
| NCT00001317 | Completed | Phase 4 | A Phase IV Study of Recombinant Human Gamma Interferon in Patients With Chronic Granulomatous Diseases of Childhood | May 1992 | July 2001 |
| NCT01917708 | Completed | Phase 1 | Bone Marrow Transplant With Abatacept for Non-Malignant Diseases | January 2014 | September 19, 2019 |
| NCT01998633 | Completed | Phase 2 | Reduced Intensity Conditioning for Hemophagocytic Syndromes or Selected Primary Immune Deficiencies (BMT CTN 1204) | December 2013 | December 2016 |
| NCT02116764 | Completed | Analysis of Patients Treated for Chronic Granulomatous Disease Since January 1, 1995 | June 11, 2014 | June 2, 2022 | |
| NCT00005933 | Completed | Learning and Behavior Problems in Children With Chronic Granulomatous Disease and Related Disorders | June 2000 | July 2005 | |
| NCT00799071 | Completed | Phase 2 | Pharmacokinetics of Posaconazole in Children With Chronic Granulomatous Disease (CGD) | February 2009 | August 2010 |
| NCT00927134 | Completed | Phase 1/Phase 2 | Gene Therapy for X-linked Chronic Granulomatous Disease (CGD) in Children | June 2004 | September 2011 |
| NCT04136028 | Completed | Early Phase 1 | IL-1 Receptor Inhibitor for Granulomatous Complications in Patients With Chronic Granulomatous Disease | September 25, 2015 | January 2020 |
| NCT06253507 | Enrolling by invitation | Phase 1/Phase 2 | pCCLCHIM-p47 (Lentiviral Vector Transduced CD34 Plus Cells) in Patients With p47 Autosomal Recessive Chronic Granulomatous Disease (AR-CGD) | June 23, 2024 | March 31, 2027 |
| NCT03655223 | Enrolling by invitation | Early Check: Expanded Screening in Newborns | October 15, 2018 | December 31, 2025 | |
| NCT05104723 | Enrolling by invitation | Phase 1/Phase 2 | Safety and Efficacy of Tofacitinib for Chronic Granulomatous Disease With Inflammatory Complications | August 12, 2022 | January 1, 2027 |
| NCT03983837 | Enrolling by invitation | Phase 2 | Elemental Diet for Treatment of Inflammatory Bowel Disease in Patients With Chronic Granulomatous Disease | June 23, 2021 | June 23, 2026 |
| NCT01652092 | Recruiting | N/A | Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies | September 4, 2012 | December 2026 |
| NCT03910452 | Recruiting | Early Phase 1 | Haploidentical Transplant for People With Chronic Granulomatous Disease (CGD) Using Alemtuzumab, Busulfan and TBI With Post-Transplant Cyclophosphamide | October 28, 2019 | June 15, 2034 |
| NCT05189925 | Recruiting | Phase 1 | NADPH Oxidase Correction in mRNA-transfected Granulocyte-enriched Cells in Chronic Granulomatous Disease (CGD) | July 22, 2022 | July 1, 2026 |
| NCT06162936 | Recruiting | Neutrophil Oxidative Burst in Early and Late Onset Pediatric Inflammatory Bowel Disease | November 1, 2023 | February 2025 | |
| NCT05463133 | Recruiting | Phase 1/Phase 2 | Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease (CGD) With an Alemtuzumab, Busulfan and TBI-based Conditioning Regimen Combined With Cytokine (IL-6, +/- IFN-gamma) Antagonists | July 8, 2022 | December 31, 2032 |
| NCT01821781 | Recruiting | Phase 2 | Immune Disorder HSCT Protocol | March 2013 | March 2027 |
| NCT02108028 | Recruiting | Study of Voicing My CHOiCES as a Tool for Advanced Care Planning in Young Adults With Cancer | April 3, 2014 | December 31, 2024 | |
| NCT05687474 | Recruiting | Baby Detect : Genomic Newborn Screening | September 1, 2022 | August 31, 2025 | |
| NCT05600907 | Recruiting | Early Phase 1 | Study to Assess the Use of JSP191 in Matched Unrelated Donor Transplantation for Chronic Granulomatous Disease (CGD) | January 2, 2023 | November 30, 2036 |
| NCT02282904 | Terminated | Phase 1/Phase 2 | Haploidentical Transplant for People With Chronic Granulomatous Disease Using Post Transplant Cyclophosphamide | October 23, 2014 | December 10, 2019 |
| NCT00006054 | Terminated | N/A | Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies | March 2000 | December 2002 |
| NCT00325078 | Terminated | Phase 1/Phase 2 | Infliximab to Treat Crohn'S-like Inflammatory Bowel Disease in Chronic Granulomatous Disease | May 2006 | June 2012 |
| NCT00394316 | Terminated | Early Phase 1 | Gene Therapy for Chronic Granulomatous Disease | October 30, 2006 | April 8, 2014 |
| NCT02512679 | Terminated | Phase 2 | Related Hematopoietic Stem Cell Transplantation (HSCT) for Genetic Diseases of Blood Cells | February 2007 | February 2014 |
| NCT02926963 | Terminated | N/A | Generation of Powerful Biological Tools for Understanding the Pathophysiology of Chronic Granulomatous Disease. | October 2010 | June 2017 |
| NCT03080480 | Terminated | Phase 1/Phase 2 | Pioglitazone Therapy for Chronic Granulomatous Disease | September 1, 2017 | October 20, 2019 |
| NCT05915897 | Terminated | Whole Blood Biospecimen Collection for Subjects With Chronic Granulomatous Disease (CGD) | May 23, 2023 | March 25, 2024 | |
| NCT03547830 | Unknown status | Phase 2 | Plerixafor/G-CSF as Additional Agents for Conditioning Before HSCT in CGD Patients | April 13, 2019 | January 1, 2023 |
| NCT00778882 | Unknown status | Phase 1/Phase 2 | Gene Therapy for Chronic Granulomatous Disease in Korea | January 2007 | October 2022 |
| NCT01338675 | Unknown status | Phase 1/Phase 2 | Targeted Busulfan, Fludarabine Conditioning Regimen for Hematopoietic Stem Cell Transplantation in Chronic Granulomatous Disease(CGD) | January 2011 | December 2013 |
| NCT03645486 | Unknown status | N/A | Lentiviral Gene Therapy for CGD | July 1, 2018 | December 31, 2021 |
| NCT03278912 | Withdrawn | Natural History of Intestinal Inflammation in People With Primary Immune Dysregulations | September 8, 2023 | September 8, 2023 |
- Disase is a (Disease Ontology)
- DOID:3262
- Cross Reference ID (Disease Ontology)
- GARD:6100
- Cross Reference ID (Disease Ontology)
- ICD10CM:D71
- Cross Reference ID (Disease Ontology)
- MESH:D006105
- Cross Reference ID (Disease Ontology)
- MIM:PS306400
- Cross Reference ID (Disease Ontology)
- NCI:C26788
- Cross Reference ID (Disease Ontology)
- ORDO:379
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:11210002
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0018203
- Exact Synonym (Disease Ontology)
- Bridges-Good syndrome
- Exact Synonym (Disease Ontology)
- CGD
- Exact Synonym (Disease Ontology)
- Congenital dysphagocytosis
- Exact Synonym (Disease Ontology)
- Quie syndrome
- OrphaNumber from OrphaNet (Orphanet)
- 379