Annotation Detail
Information
- Associated Genes
- TNF
- Associated Variants
-
TNF MUTATION
TNF MUTATION - Associated Disease
- Malignant neoplasm of breast
- Source Database
- DisGeNET
- Description
- The important function of FASN in the drug tolerance of breast cancer may be due to the following mechanisms: FASN downregulated TNFR-2 expression through lipid rafts to make the cells less sensitive to TNF-α, and simultaneously activated the Wnt-1/β-catenin signalling pathway.
- Pubmed
- 25292037
- Section of the abstract supporting the evidence
- CONCLUSIONS
- Number of the section of the abstract supporting the evidence
- 4
- Number of the sentence supporting the evidence
- 7
- Original source reporting the Gene Disease association
- BeFree,GAD
- DisGENET score for the Gene Disease association
- 0.0702936465670275
Drugs