Down syndrome
Information
- Disease name
- Down syndrome
- Disease ID
- DOID:14250
- Description
- "A chromosomal disease that is characterized by flat-looking facial features and weak muscle tone (hypotonia) in infancy and is caused by trisomy of all or a critical portion of chromosome 21 and is associated with intellectual disability." [url:http\://en.wikipedia.org/wiki/Down_syndrome, url:http\://ghr.nlm.nih.gov/condition/down-syndrome, url:http\://www.nichd.nih.gov/health/topics/down/Pages/default.aspx, url:http\://www.omim.org/entry/190685?search=down%20syndrome&highlight=down%20syndromic%20syndrome, url:https\://research.nhgri.nih.gov/atlas/condition/trisomy-21]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT05492981 | Active, not recruiting | N/A | Does an Educational Video for Aneuploidy Screening Improve Informed Choice Among Pregnant Women? | July 5, 2021 | July 30, 2022 |
| NCT04603352 | Active, not recruiting | N/A | Impact of an Orthotic Garment on Gross Motor Skills for Infants With Down Syndrome | May 5, 2021 | December 30, 2024 |
| NCT04668001 | Active, not recruiting | N/A | Transcranial Photobiomodulation With Near-Infrared Light for Language in Individuals With Down Syndrome | October 19, 2021 | September 1, 2024 |
| NCT03771469 | Active, not recruiting | N/A | Validation of Sleep Questionnaires in the Down Syndrome Population | June 25, 2018 | January 1, 2025 |
| NCT02521493 | Active, not recruiting | Phase 3 | Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome | December 23, 2015 | June 30, 2024 |
| NCT03210675 | Active, not recruiting | N/A | Early Detection and Treatment of Respiratory Sleep Disorders in Children With Down Syndrome | July 31, 2017 | June 30, 2024 |
| NCT04208685 | Active, not recruiting | Evaluating Cognitive Outcomes in Down Syndrome | June 18, 2018 | June 2026 | |
| NCT01190930 | Active, not recruiting | Phase 3 | Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma | August 9, 2010 | March 31, 2028 |
| NCT00695695 | Completed | The Experience of Caregivers of Children With Down Syndrome | May 14, 2008 | February 3, 2014 | |
| NCT00748007 | Completed | N/A | Efficacy of Rivastigmine in Patients With Down Syndrome | January 2008 | December 2009 |
| NCT00825175 | Completed | N/A | Treadmill Training and Orthotic Use in Infants With Down Syndrome | March 2006 | June 2008 |
| NCT00844259 | Completed | Functional Communicative Profile of Children With Down Syndrome | July 2006 | October 2007 | |
| NCT00847990 | Completed | Non-Invasive Screening for Fetal Aneuploidy | March 2009 | August 2011 | |
| NCT00864461 | Completed | Frequency of Metabolic Syndrome in Down Syndrome Patients | September 1, 2009 | March 31, 2010 | |
| NCT00877292 | Completed | A New Prenatal Blood Test for Down Syndrome | February 2009 | May 2011 | |
| NCT00928304 | Completed | Phase 2 | Phase II Study of Florbetaben (BAY94-9172) PET Imaging for Detection/Exclusion of Cerebral β-amyloid. | June 2009 | January 2011 |
| NCT00951730 | Completed | Evaluation of a Simplified Method for Diagnosis of Sleep Apnea in Children and Adults With Down Syndrome | February 2010 | February 2015 | |
| NCT02046889 | Completed | N/A | A Bicycle Training Intervention | June 2010 | December 2012 |
| NCT00287417 | Completed | Early Ultrasound and Maternal Biochemical Markers to Evaluate the Risk of Down Syndrome During the First Trimester | July 2003 | February 2011 | |
| NCT00294593 | Completed | Phase 2/Phase 3 | Efficacy Study of Folinic Acid to Improve Mental Development of Children With Down Syndrome | October 2000 | December 2003 |
| NCT00394290 | Completed | N/A | Down Syndrome and Continuous Positive Pressure Therapy | November 16, 2006 | December 31, 2012 |
| NCT00570128 | Completed | Phase 2 | Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (HCl) (Aricept) In Treating Cognitive Dysfunction Exhibited By Children With Down Syndrome | November 16, 2007 | September 5, 2008 |
| NCT00643552 | Completed | Muscle Strength, Physical Work Capacity and Functional Performance in Individuals With Down Syndrome | |||
| NCT00668980 | Completed | Symbolic Representation in Young Children With Down Syndrome | July 2006 | April 2009 | |
| NCT00689988 | Completed | N/A | Augmentative and Alternative Communication (AAC) and Lexical Gain in Children With Down Syndrome | July 2005 | June 2008 |
| NCT01684670 | Completed | N/A | Intensive Dysarthria Sessions in Adults and Children With Down Syndrome | February 2014 | May 2016 |
| NCT01778946 | Completed | Phase 1/Phase 2 | Nicotine Treatment of Cognitive Decline in Down Syndrome | April 2013 | February 2021 |
| NCT01791725 | Completed | Phase 2 | A 4-Week Safety Study of Oral ELND005 in Young Adults With Down Syndrome Without Dementia | September 2013 | June 2014 |
| NCT01808508 | Completed | N/A | Obstructive Sleep Apnea and Neurocognitive and Cardiovascular Function in Children With Down Syndrome | September 2010 | September 2014 |
| NCT01821300 | Completed | Down Syndrome Metabolic Health Study | February 2013 | August 25, 2017 | |
| NCT01832753 | Completed | N/A | Treatment Trial of Subclinical Hypothyroidism in Down Syndrome | January 2013 | October 18, 2017 |
| NCT01920633 | Completed | A Screening Protocol to Assess Adults and Adolescents With Down Syndrome for Eligibility For Upcoming Study of RG1662 (Study BP27832) | October 31, 2013 | January 31, 2015 | |
| NCT02024789 | Completed | Phase 2 | A Study of RG1662 in Adults and Adolescents With Down Syndrome (CLEMATIS) | May 5, 2014 | May 4, 2016 |
| NCT00005190 | Completed | Reproduction and Survival After Cardiac Defect Repair | July 1986 | December 1998 | |
| NCT02094053 | Completed | Phase 2 | A Double-blind, Placebo-controlled Comparative Study and Open-label Extension Study to Confirm the Efficacy and Safety of E2020 in Subjects With Down Syndrome Having Regression Symptoms and Disabled Activities of Daily Living. | September 12, 2013 | April 21, 2017 |
| NCT02127515 | Completed | N/A | Non Invasive Prenatal Testing of Down Syndrome | April 8, 2014 | November 7, 2016 |
| NCT02141971 | Completed | Down Syndrome Biomarker Initiative (DSBI) | June 1, 2013 | April 15, 2017 | |
| NCT02158390 | Completed | N/A | Phenotypic Specific Communication Intervention for Children With Down Syndrome | June 2014 | February 6, 2018 |
| NCT02201862 | Completed | Non-Invasive Chromosomal Evaluation of Trisomy Study | April 2014 | August 1, 2019 | |
| NCT02304302 | Completed | Phase 2 | Down Syndrome Memantine Follow-up Study | October 2014 | July 22, 2020 |
| NCT02344108 | Completed | N/A | A Pilot Study to Evaluate the Hypoglossal Nerve Stimulator in Adolescents With Down Syndrome and Obstructive Sleep Apnea | February 2015 | September 2, 2021 |
| NCT02380638 | Completed | N/A | Effects of Whole-body Vibration Training on Body Composition in Adolescents With and Without Down Syndrome | January 2010 | December 2012 |
| NCT02421276 | Completed | N/A | Depressed AIRE Gene Expression Causes Immune Cell Dysfunction & Autoimmunity in Down Syndrome | October 19, 2015 | February 2018 |
| NCT02431117 | Completed | Non-drug Study to Assess the Suitability of Assessment Scales in Japanese Individuals With Down Syndrome Aged 6-30 | June 2015 | July 2016 | |
| NCT02432716 | Completed | Phase 1 | Investigation of the Safety of Intranasal Glulisine in Down Syndrome | April 2015 | October 18, 2018 |
| NCT02451657 | Completed | Non-drug Study to Evaluate the Suitability of Neurocognitive Tests and Functioning Scales for the Measurement of Cognitive and Functioning Changes in Children With Down Syndrome | June 2, 2015 | June 30, 2016 | |
| NCT02481765 | Completed | N/A | Feasibility and Dose Tolerability of HD-tDCS in Healthy Adults and Children With Down Syndrome | September 15, 2015 | May 20, 2016 |
| NCT02561754 | Completed | N/A | Weight Management for Adolescents With IDD | March 2015 | May 5, 2021 |
| NCT02719600 | Completed | N/A | Motor Learning Through Virtual Reality Task in Individuals With Down Syndrome | March 2015 | March 2016 |
| NCT02738450 | Completed | Phase 1 | Safety, Tolerability and Immunogenicity of ACI-24 Vaccine in Adults With Down Syndrome | March 2016 | June 2020 |
| NCT02759887 | Completed | N/A | Relationship Between Down Syndrome (DS) and Alzheimer's Disease (AD) | November 2016 | December 2018 |
| NCT02787486 | Completed | Expanded Noninvasive Genomic Medical Assessment: The Enigma Study | October 2015 | September 2018 | |
| NCT02859389 | Completed | Neurocognitive and Psychosocial Outcomes in Survivors of Childhood Leukemia With Down Syndrome | August 18, 2016 | January 31, 2019 | |
| NCT02882698 | Completed | N/A | Performance Analysis in Down Syndrome on Mobile Phone | September 2016 | December 2016 |
| NCT02895802 | Completed | N/A | Assessing the Feasibility of the Use of Visual Aids in Patient Education in Adults With Down Syndrome (DS) | August 2016 | October 25, 2017 |
| NCT02971254 | Completed | Phase 2 | The Effects of Inhalational Anaesthetics in Cognitive Functions in Down Syndrome Patients | December 1, 2016 | May 30, 2019 |
| NCT02996175 | Completed | N/A | Treatment of Sleep Disturbances in School-age Children With Down Syndrome | July 2015 | May 2018 |
| NCT03058640 | Completed | N/A | Effects of Karate in Adolescents With Down Syndrome | July 15, 2017 | March 31, 2019 |
| NCT03084497 | Completed | N/A | Effects of Infant Massage on Development of Down Syndrome Babies | August 2016 | October 2016 |
| NCT03087357 | Completed | VAlidation of a Lower Cost aneUploidy scrEen | October 10, 2017 | October 1, 2020 | |
| NCT03135236 | Completed | N/A | Parents as the Primary Sexuality Educators for Their Young Adults With Down Syndrome | March 6, 2017 | June 1, 2018 |
| NCT03192540 | Completed | N/A | The Impact of an 8-week Supported Exercise Program on Fitness and Symptoms in Adolescents With Down Syndrome | September 15, 2018 | March 31, 2021 |
| NCT03200041 | Completed | N/A | Clinical Evaluation of the IONA Test for Non-invasive Pre Natal Screening in Twin Pregnancies | February 2016 | December 2019 |
| NCT03267602 | Completed | N/A | Role of Sleep Apnea in the Neuropsychological Function in Down Syndrome People | December 2012 | December 2016 |
| NCT03441685 | Completed | N/A | Strategies for Teaching Verbs | March 21, 2018 | July 2, 2021 |
| NCT03445962 | Completed | 19/5000 (SYNAPSOT21) Predictive Factors of Sleep Apnea Syndrome in Down Syndrome | November 15, 2017 | July 11, 2019 | |
| NCT03522337 | Completed | N/A | Oral Health Promotion Among Preschool Children With Special Needs | April 12, 2016 | September 30, 2018 |
| NCT03538925 | Completed | Phase 2 | Building Sentences With Preschoolers Who Use AAC | May 11, 2018 | December 31, 2023 |
| NCT03544840 | Completed | N/A | Investigating Trunk Control in Young Children With Down Syndrome | July 1, 2018 | January 31, 2019 |
| NCT03624556 | Completed | N/A | Pediatric Exploratory Research Study of EGCG Use and Safety (PERSEUS) | January 29, 2018 | November 30, 2020 |
| NCT03677245 | Completed | N/A | Balance Bike Training in Down Syndrome | November 26, 2018 | June 1, 2019 |
| NCT03684512 | Completed | N/A | Promotion of Physical Activity in Adolescents With Intellectual and Developmental Disabilities | January 7, 2019 | October 28, 2022 |
| NCT03698539 | Completed | How Stuttering and Gestures Influence the Intelligibility of Individuals With Down Syndrome | December 5, 2018 | September 10, 2021 | |
| NCT03903666 | Completed | N/A | Anomalies of Nocturnal Gaz Exchanges in Patients With Down Syndrome | October 14, 2019 | May 23, 2022 |
| NCT03922165 | Completed | Healthy Sleep for Children With Down Syndrome | May 22, 2019 | December 31, 2021 | |
| NCT03935620 | Completed | N/A | Delivering Early Intervention to Children With Down Syndrome | June 1, 2019 | December 1, 2021 |
| NCT04020302 | Completed | N/A | Self-Monitoring Shopping Intervention | September 6, 2019 | December 20, 2019 |
| NCT04035967 | Completed | Investigation of Parents' Anxiety Level and Health Related Quality of Life in Different Types of Physical Disabilities | May 1, 2017 | May 1, 2019 | |
| NCT04048759 | Completed | N/A | The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults With Down Syndrome | January 21, 2020 | November 22, 2023 |
| NCT04059354 | Completed | N/A | Down Syndrome Speech Intelligibility Diagnostic Treatment Study | August 30, 2019 | February 28, 2020 |
| NCT04115878 | Completed | Phase 2 | Medications for Obstructive Sleep Apnea In Children With Down Syndrome | October 21, 2020 | December 30, 2022 |
| NCT04124471 | Completed | N/A | Investigating the Experience of Living With Down Syndrome and Obstructive Sleep Apnea Syndrome (Stage 1) | August 2, 2019 | August 1, 2022 |
| NCT04156607 | Completed | N/A | The Effects of Kinesiotaping on Balance in Children With Down Syndrome. | February 25, 2018 | May 15, 2018 |
| NCT04227197 | Completed | N/A | An Online Health Tool About Down Syndrome: Down Syndrome Clinic to You | October 3, 2017 | May 15, 2019 |
| NCT04293380 | Completed | N/A | Amniotic Fluid Ischemia Modified Albumin as a Novel e Prenatal Diagnostic Marker for Down Syndrome | March 1, 2012 | September 1, 2016 |
| NCT04390321 | Completed | N/A | Application of LLM Care and Related Affective Computing Systems on Persons With Special Needs | February 22, 2017 | January 1, 2022 |
| NCT04394221 | Completed | OHRQoL and Parental Perception in a Group of Children and Adolescents With Down Syndrome: A Cross | April 15, 2021 | December 15, 2021 | |
| NCT04536506 | Completed | N/A | Bobath and Vojta Therapy for DS | September 26, 2019 | January 26, 2020 |
| NCT04539535 | Completed | N/A | Infants With Down Syndrome on a Different Surface | June 1, 2019 | June 30, 2020 |
| NCT04583332 | Completed | N/A | Efficacy of AAC for Functional Communication | January 1, 2020 | December 15, 2020 |
| NCT04647851 | Completed | N/A | Remote Exercise Study for Individuals With Down Syndrome | November 18, 2020 | December 31, 2022 |
| NCT04657276 | Completed | Turkish Adaptation of Segmental Assessment of Trunk Control Scale | June 1, 2021 | December 30, 2022 | |
| NCT04735874 | Completed | Vascular Health and Risk Factors in Children With Down Syndrome | February 2, 2021 | June 30, 2023 | |
| NCT04751136 | Completed | Phase 2 | the Effect of Cerebrolysin on Physical and Mental Functions of Down Syndrome | September 30, 2016 | August 30, 2019 |
| NCT04767412 | Completed | N/A | Inspiratory Muscle Training and Physical Fitness in Children With Down Syndrome Randomized Control Trial | September 3, 2020 | January 21, 2021 |
| NCT04787861 | Completed | N/A | Motorized Movement Therapy & Pulmonary Functions in Down Syndrome | December 17, 2018 | May 4, 2020 |
| NCT04816409 | Completed | N/A | Effect of Neuro Developmental Therapy in Infants With Down Syndrome | March 15, 2019 | January 30, 2020 |
| NCT04818437 | Completed | N/A | Effect of Core Stability Exercises and Balance Training in Postural Control Among Down Syndrome | September 15, 2019 | March 30, 2020 |
| NCT04966403 | Completed | N/A | Effects of Stretch-shortening Cycle Exercises Postural Control in Down Syndrome | December 1, 2018 | June 5, 2020 |
| NCT05020366 | Completed | N/A | Preventing Obesity Through Parent Empowerment and the Activation of Routines (PrO-PEAR) | October 4, 2021 | May 23, 2023 |
| NCT05024110 | Completed | N/A | Effect of Exercise Intensity on Vitamin D | January 25, 2021 | May 14, 2021 |
| NCT05098600 | Completed | The Epidemiology, Management and Comorbidities in Alopecia Areata in Czech Republic | October 15, 2021 | December 20, 2022 | |
| NCT05120531 | Completed | Down Syndrome Autonomic Nervous System Induction Bradycardia | January 4, 2022 | December 12, 2023 | |
| NCT05131542 | Completed | Assessment of Hypotonia in Children With Down Syndrome | April 1, 2019 | January 15, 2022 | |
| NCT05191654 | Completed | Investigation of Cardiopulmonary Parameters, Motor Development and Muscle Strength in DS With and Without CHD | October 1, 2020 | June 30, 2021 | |
| NCT05198232 | Completed | N/A | The Effects of Virtual Zumba® in Individuals With Developmental Disabilities | January 26, 2021 | March 30, 2022 |
| NCT05228405 | Completed | Awareness Levels of Caregivers of Disabled Children | April 15, 2019 | August 15, 2019 | |
| NCT05271201 | Completed | N/A | Exercise Intensity for Down Syndrome Children | December 10, 2019 | March 27, 2020 |
| NCT05297149 | Completed | N/A | Effect of Hippotherapy in Children With Down Syndrome | November 30, 2020 | January 25, 2021 |
| NCT05307523 | Completed | N/A | Use of Partial Body Weight Support Play Environment to Encourage Mobility and Exploration in Infants With Down Syndrome | February 14, 2022 | May 13, 2023 |
| NCT05312177 | Completed | Congenital Heart Disease: Impact on Learning and Development in Down Syndrome (CHILD-DS) | May 1, 2022 | December 31, 2023 | |
| NCT05343468 | Completed | N/A | Life Skills Improved in Children With Down Syndrome After Using Assistive Technology | September 20, 2020 | August 5, 2021 |
| NCT05528549 | Completed | Phase 3 | Blood Flow and Blood Pressure Investigation in Down Syndrome | September 1, 2022 | April 26, 2023 |
| NCT05583565 | Completed | N/A | Effect of the Sensory Integration Approach on Balance and Motor Coordination in Children With Down Syndrome | May 14, 2021 | February 12, 2022 |
| NCT05702632 | Completed | N/A | TheraTogs Versus Reciprocal Electrical Stimulation on Children With Diplegic Cerebral Palsy: a Randomized Controlled Trial | July 15, 2022 | December 30, 2022 |
| NCT05740046 | Completed | N/A | Motor Intervention Whit the Intorus Tool on Children With Down Syndrome | February 1, 2023 | July 31, 2023 |
| NCT05769556 | Completed | N/A | Effect Of Brain Gym Exercises On Postural Stability In Children With Down Syndrome | May 1, 2023 | November 28, 2023 |
| NCT05904821 | Completed | Relationship Between BMI, Physical Fitness and Motor Skills in Children With Down's Syndrome | May 23, 2023 | September 15, 2023 | |
| NCT05912803 | Completed | N/A | Effects of Simulated Equestrian Therapy on Motor Proficiency and Gait Parameters Among Down Syndrome Children | January 29, 2023 | August 25, 2023 |
| NCT05915780 | Completed | N/A | Effect of Aerobic Exercises on Static & Dynamic Balance | May 3, 2023 | June 6, 2023 |
| NCT05951543 | Completed | N/A | Effects of Plyometric Exercises on Static and Dynamic Balance of Children With Down,s Syndrome. | May 23, 2023 | September 15, 2023 |
| NCT05969873 | Completed | N/A | Effect Of Pilates On Postural Control And Balance In Children With Down's Syndrome | July 16, 2023 | November 15, 2023 |
| NCT05978778 | Completed | N/A | Effects of Active Video Gaming on Pre-handwriting Skills of Children With Down Syndrome. | May 27, 2023 | September 15, 2023 |
| NCT06125990 | Completed | N/A | Video Based Breathing Exercise Rehabilitation | April 14, 2023 | August 14, 2023 |
| NCT06131099 | Completed | N/A | Effects of Dohsa Hou Exercises on Functional Mobility | November 15, 2023 | February 28, 2024 |
| NCT06196983 | Completed | N/A | Effects of Rhythmic Aerobic Exercises on Functional Balance in Children With Down Syndrome | December 1, 2023 | February 5, 2024 |
| NCT06198075 | Completed | N/A | Action Observation Therapy on Balance in Children With Down Syndrome | December 1, 2023 | February 5, 2024 |
| NCT06234644 | Completed | N/A | Effects of Maze Activities in Down's Syndrome | December 5, 2023 | February 10, 2024 |
| NCT06244108 | Completed | N/A | Occupational Therapy Home Programs in Children With Down Syndrome | January 10, 2023 | January 15, 2024 |
| NCT06263777 | Completed | N/A | Early Detection of Children With Developmental Disabilities in Assiut Governorate | January 1, 2021 | September 30, 2021 |
| NCT00971334 | Completed | Noninvasive Screening for Fetal Aneuploidy: A New Maternal Plasma Marker | August 2009 | December 2011 | |
| NCT01034280 | Completed | Correlations Phenotype / Genotype in Down Syndrome | March 2004 | May 2011 | |
| NCT01052688 | Completed | Noninvasive Screening for Affected Pregnancies: Assay Development & Optimization in Affected Pregnancies | November 2009 | August 31, 2021 | |
| NCT01084135 | Completed | Phase 1/Phase 2 | Rivastigmine Study in Adolescents With Down Syndrome | November 2009 | February 2014 |
| NCT01112683 | Completed | Phase 4 | Efficacy and Safety of Memantine Hydrochloride in Enhancing the Cognitive Abilities of Young Adults With Down Syndrome | July 2008 | August 2011 |
| NCT01148121 | Completed | N/A | Assessment of Bone Density and Bone Turnover Markers in Patients With Down Syndrome and Comparison to the Ts65Dn Model | June 2010 | August 2015 |
| NCT01176019 | Completed | Phase 1 | An Interactive Informed Consent and Education Program for Pregnant Women | August 2010 | March 2011 |
| NCT01256112 | Completed | N/A | Parent Supported Weight Reduction in Down Syndrome | September 2006 | March 2010 |
| NCT01303133 | Completed | Natural History of Amyloid Deposition in Adults With Down Syndrome | August 2009 | March 31, 2018 | |
| NCT01313325 | Completed | N/A | Hippotherapy to Improve the Balance of Children With Movement Disorders | September 2006 | December 2007 |
| NCT01390558 | Completed | Gait Parameters of Persons With Down Syndrome With and Without Orthotics Using GaitRite | June 2011 | August 27, 2018 | |
| NCT01394796 | Completed | Phase 2 | Egcg, a dyrk1a Inhibitor as Therapeutic Tool for Reversing Cognitive Deficits in Down Syndrome Individuals. | May 2010 | February 2011 |
| NCT01436955 | Completed | Phase 1 | A Study of RG1662 in Individuals With Down Syndrome | November 2011 | September 2013 |
| NCT01555346 | Completed | Clinical Evaluation of the SEQureDx T21 Test In High Risk Pregnancies | March 2012 | December 2015 | |
| NCT01576705 | Completed | Phase 3 | Efficacy Assessment of Systematic Treatment With Folinic Acid and Thyroid Hormone on Psychomotor Development of Down Syndrome Young Children | April 2, 2012 | December 14, 2017 |
| NCT01580384 | Completed | A Non-Drug Study of The Suitability of Neurocognitive Tests And Functioning Scales For The Measurement of Cognitive And Functioning Changes in Individuals With Down Syndrome | February 2012 | January 2014 | |
| NCT01594346 | Completed | Phase 3 | Multicenter Vitamin E Trial in Aging Persons With Down Syndrome | September 2000 | April 2010 |
| NCT01597063 | Completed | Clinical Evaluation of the SEQureDx Trisomy Test in Low Risk Pregnancies | July 2012 | December 2015 | |
| NCT01598350 | Completed | N/A | Gait in Children With Down Syndrome While Wearing Orthoses | January 2010 | June 2011 |
| NCT01663350 | Completed | Comparison of Aneuploidy Risk Evaluations | July 2012 | ||
| NCT05301361 | Enrolling by invitation | Phase 1 | Sensitivity of the NIH Toolbox to Stimulant Treatment in Intellectual Disabilities | February 1, 2023 | September 29, 2026 |
| NCT01902407 | Enrolling by invitation | Computer Models of Airways in Children and Young Adults With Sleep Apnea and Down Syndrome | March 2011 | December 2027 | |
| NCT03836300 | Enrolling by invitation | N/A | Parent and Infant Inter(X)Action Intervention (PIXI) | November 30, 2018 | June 30, 2025 |
| NCT06293911 | Enrolling by invitation | N/A | Clinical Comparison of a Postbiotic-gel With Placebo Gel for Gingival Inflammation in Patients With Down Syndrome | March 15, 2024 | July 28, 2025 |
| NCT05508971 | Enrolling by invitation | N/A | Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS) | August 23, 2023 | June 30, 2027 |
| NCT06336577 | Not yet recruiting | Infectious and Non-infectious Lower Respiratory Diseases in Children With Down Syndrome Followed in Pediatric Pulmonology Consultations in Ile-de-France | April 1, 2024 | December 31, 2024 | |
| NCT06219863 | Not yet recruiting | N/A | Harness-based Mobility Intervention for Infants With Down Syndrome | June 15, 2024 | March 31, 2025 |
| NCT06146907 | Not yet recruiting | N/A | A Comparison of Cognitive-Motor Dual-Task Exercise and Exergaming on Balance, Functional Mobility, and Executive Function in Down Syndrome Children | August 14, 2024 | June 20, 2025 |
| NCT05473247 | Not yet recruiting | N/A | GameSquad for Adults With Down Syndrome | January 15, 2023 | August 30, 2030 |
| NCT05985486 | Not yet recruiting | N/A | Brain Outcomes With Lifestyle Change in Down Syndrome | October 1, 2024 | September 30, 2027 |
| NCT06461858 | Not yet recruiting | N/A | Effects of Cuevas Medek Exercises on Trunk Control and Balance in Children With Down Syndrome | June 10, 2024 | October 1, 2024 |
| NCT05719662 | Not yet recruiting | N/A | Weight Bearing Exercises With and Without Jaffrey's Core Stability Exercise Training in Children With Down Syndrome. | February 10, 2023 | September 30, 2023 |
| NCT06117228 | Not yet recruiting | Gynaecological Follow-up of Women With Down Syndrom Aged 18 to 30 in France | December 1, 2023 | May 1, 2024 | |
| NCT02864108 | Recruiting | The Crnic Institute Human Trisome Project Biobank | July 2016 | July 2036 | |
| NCT05482334 | Recruiting | Phase 2 | Trial to Evaluate Safety and Efficacy of GM-CSF /Sargramostim in Down Syndrome | October 23, 2023 | September 2026 |
| NCT05527652 | Recruiting | N/A | Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia | November 16, 2022 | August 2026 |
| NCT04132999 | Recruiting | N/A | PAP for Children With DS and OSAS | March 1, 2021 | September 2024 |
| NCT04165109 | Recruiting | Trial-Ready Cohort-Down Syndrome (TRC-DS) | June 7, 2021 | December 2025 | |
| NCT01429389 | Recruiting | Specimen Collection From Pregnant Women at Increased Risk for Fetal Aneuploidy | May 2011 | March 2025 | |
| NCT04219280 | Recruiting | Phase 4 | Evaluating Treatment of ADHD in Children With Down Syndrome | October 2, 2020 | September 30, 2025 |
| NCT05638412 | Recruiting | N/A | Investigating the Impact of JASPER Behavioral Therapy in Children With Down Syndrome | January 23, 2023 | January 2025 |
| NCT04246372 | Recruiting | Phase 2 | Tofacitinib for Immune Skin Conditions in Down Syndrome | October 21, 2020 | December 2024 |
| NCT04278404 | Recruiting | Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) | March 5, 2020 | July 2024 | |
| NCT05662228 | Recruiting | Phase 2 | Therapies for Down Syndrome Regression Disorder | June 29, 2023 | December 2026 |
| NCT06197035 | Recruiting | N/A | The Coping With and Caring for Infants With Special Needs Intervention in Down Syndrome Infants | March 10, 2024 | October 20, 2024 |
| NCT01950624 | Recruiting | DS-Connect {TM}: The Down Syndrome Registry | September 6, 2013 | ||
| NCT05748405 | Recruiting | Phase 1/Phase 2 | Phase 1/2 Trial of AEF0217 in Participants With Down Syndrome | December 15, 2022 | June 2024 |
| NCT04631237 | Recruiting | Developing a Down Syndrome Health Instrument | April 3, 2020 | March 31, 2025 | |
| NCT05767203 | Recruiting | N/A | Genetic Markers and Biomarkers in Patients With Intellectual Disabilities of Genetic Origin | September 1, 2022 | December 31, 2032 |
| NCT05767216 | Recruiting | N/A | Genetic and Epigenetic Variations in Heterokaryotypic Monozygotic Twins Discordant for Down Syndrome | December 20, 2022 | December 30, 2028 |
| NCT06352151 | Recruiting | N/A | Effects of Orofacial Therapy and Therapeutic Yoga in Children With Down Syndrome | October 1, 2023 | December 30, 2024 |
| NCT05849818 | Recruiting | N/A | Virtual Reality Technology For Cognitive Functions Of Children With Down Syndrome | May 2023 | August 2023 |
| NCT05861141 | Recruiting | N/A | Effect of Aerobic Training on Sleep Problems and Pulmonary Functions in Children With Down Syndrome | September 1, 2023 | May 2024 |
| NCT04801771 | Recruiting | Phase 3 | Effects of Hypoglossal Nerve Stimulation on Cognition and Language in Down Syndrome and Obstructive Sleep Apnea | June 24, 2021 | March 31, 2025 |
| NCT04811534 | Recruiting | Qualitative Exploratory Study Among Reunionese Women and Their Partners Who Have a Child With Trisomy 21 | February 28, 2022 | June 2025 | |
| NCT06206824 | Recruiting | Phase 1 | Leucettinib-21 First-in-Human Phase 1 in Healthy Volunteers and Subjects With Down Syndrome and Alzheimer's Disease | January 18, 2024 | August 2024 |
| NCT06213090 | Recruiting | Patterns of Neurodevelopmental Disorders | February 1, 2024 | December 31, 2030 | |
| NCT02612376 | Recruiting | Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study | February 2016 | January 2025 | |
| NCT02651493 | Recruiting | N/A | Digital Dysmorphology Project | February 2013 | December 2023 |
| NCT04854122 | Recruiting | N/A | Blood Flow Regulation in Individuals With Down Syndrome - Training Study | September 9, 2021 | August 2024 |
| NCT05928949 | Recruiting | N/A | Pilates Exercises and Down Syndrome | June 26, 2023 | September 11, 2023 |
| NCT05933603 | Recruiting | Phase 2 | Medications for Obstructive Sleep Apnea to Improve Cognition in Children With Down Syndrome | August 1, 2023 | December 2025 |
| NCT05059041 | Recruiting | Phase 2 | Dilated Versus Non-Dilated Wavefront Corrections for Patients With Down Syndrome | May 6, 2022 | January 31, 2025 |
| NCT06407895 | Recruiting | N/A | Effects of Lower Limb Fitness Program in Children With DS | May 15, 2024 | August 15, 2024 |
| NCT06450509 | Recruiting | N/A | Proactive Speech and Language Intervention for Infants With Down Syndrome | February 28, 2024 | February 27, 2025 |
| NCT05144373 | Recruiting | N/A | Role of Early Motor Experience in Infants With Down Syndrome | January 1, 2022 | August 31, 2025 |
| NCT05146739 | Recruiting | Phase 1 | Highest Dose of Uproleselan in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Mixed Phenotype Acute Leukemia Relapsed or Refractory and That Expresses E-selectin Ligand on the Cell Membrane | October 10, 2023 | December 31, 2024 |
| NCT05196984 | Recruiting | N/A | Gamma Frequency Stimulation in Individuals With Down Syndrome | December 6, 2021 | December 31, 2024 |
| NCT05995223 | Recruiting | N/A | Oxygen Uptake Kinetics During Submaximal Exercise in Adults With Down Syndrome | October 4, 2023 | December 2024 |
| NCT03233646 | Recruiting | Retinal Imaging in Neurodegenerative Disease | July 20, 2017 | December 31, 2025 | |
| NCT06030349 | Recruiting | Clinical Outcomes From Treatment and Evaluation of Obstructive Sleep Apnoea in Children With Down Syndrome | November 28, 2022 | December 28, 2027 | |
| NCT03286634 | Recruiting | Phase 2 | ASIA Down Syndrome Acute Lymphoblastic Leukemia 2016 | April 18, 2017 | March 31, 2033 |
| NCT05231798 | Recruiting | Phase 2 | Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition | August 19, 2021 | December 31, 2024 |
| NCT06036069 | Recruiting | N/A | Effect of Whole Body Vibration Versus Core Stability Exercises on Balance and Muscle Strength in Children With Down Syndrome | October 15, 2023 | January 20, 2024 |
| NCT06043440 | Recruiting | Phase 2 | Oxygen Therapy in Children and Adolescents With Down Syndrome and Obstructive Sleep Apnea | October 24, 2023 | December 27, 2027 |
| NCT06061562 | Recruiting | Down Syndrome, Physical Activity and Sleep Apnea | January 11, 2024 | December 31, 2026 | |
| NCT05310552 | Recruiting | Elucidating Age-related Comorbidity Patterns in Down Syndrome (DS) | June 10, 2021 | June 30, 2025 | |
| NCT05332912 | Recruiting | N/A | Assessing Malleability of Spatial Abilities in Down Syndrome | April 1, 2021 | July 1, 2024 |
| NCT03901261 | Recruiting | N/A | Cohort Study of Adult Patients With Down Syndrome at Risk of Developing Alzheimer's Disease (TriAL21) | April 26, 2019 | March 31, 2023 |
| NCT06279208 | Recruiting | Phosphoproteomic Profile of Children With Down Syndrome | March 18, 2024 | September 2024 | |
| NCT03914625 | Recruiting | Phase 3 | A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia | July 3, 2019 | June 30, 2029 |
| NCT05458479 | Recruiting | Phase 4 | Fluoxetine Treatment of Depression in Down Syndrome | December 5, 2022 | October 2024 |
| NCT05460910 | Recruiting | N/A | Effects of Core Stability Exercises With and Without Treadmill Training on Balance in Children With Down Syndrome | May 18, 2022 | November 15, 2022 |
| NCT04390646 | Recruiting | Phase 2/Phase 3 | GnRH Therapy on Cognition in Down Syndrome | August 27, 2020 | December 2028 |
| NCT05702645 | Recruiting | A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia | June 12, 2023 | December 16, 2028 | |
| NCT04398862 | Recruiting | Pulmonary Health in Children With Down Syndrome | August 21, 2020 | December 30, 2024 | |
| NCT04546399 | Suspended | Phase 2 | A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL) | December 4, 2020 | June 30, 2028 |
| NCT05755464 | Suspended | Evaluation of Patients With Down Syndrome Compliance to Dental Therapy | September 20, 2018 | September 20, 2024 | |
| NCT00643955 | Terminated | Neuromuscular Characteristics of Individuals With Down Syndrome (DS) | March 2008 | ||
| NCT03778528 | Terminated | Evaluation of Ocular Lens Proteins in Cataract From Individuals With Down Syndrome | May 30, 2018 | July 1, 2020 | |
| NCT03764761 | Terminated | N/A | Storybook Reading in Individuals With Down Syndrome | April 1, 2018 | November 30, 2021 |
| NCT04293120 | Terminated | N/A | Training Balance Among People With Neurodevelopmental Disabilities | February 10, 2020 | August 31, 2020 |
| NCT00754013 | Terminated | Phase 3 | Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 6 To 10 | September 2008 | December 2008 |
| NCT03551418 | Terminated | N/A | Learning by Repetitive Viewing of Peer Modeling Patient Education Videos by Adults With Down Syndrome | June 9, 2018 | August 16, 2020 |
| NCT03590665 | Terminated | N/A | Blood Flow in Individuals With Down Syndrome | March 1, 2018 | May 8, 2019 |
| NCT02484703 | Terminated | Phase 2 | A Study of RO5186582 in Down Syndrome Among Children 6 to 11 Years of Age | October 28, 2015 | August 3, 2016 |
| NCT00754052 | Terminated | Phase 3 | Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 11 To 17 | September 2008 | December 2008 |
| NCT02288702 | Terminated | Comparison of Bispectral Index Values in Patients With and Without Down's Syndrome | October 2014 | July 13, 2017 | |
| NCT02226315 | Terminated | Clinical Performance of the MaterniT21 PLUS LDT in Multiple Gestation Pregnancies | August 2014 | September 2015 | |
| NCT00675025 | Terminated | Phase 2 | Evaluating The Safety Of Donepezil Hydrochloride (Aricept) For Up To 1 Year In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome - Follow-Up To A 10-Week, Double-Blind, Placebo-Controlled Trial | April 4, 2008 | December 15, 2008 |
| NCT04754178 | Unknown status | Assessment of Skills and Behaviors in Children With Down Syndrome | February 15, 2021 | May 15, 2021 | |
| NCT04037579 | Unknown status | Protocol for a Non-randomized Survey in Down Syndrome People Who Practice Sports. Self and Observers´ Perception. | September 26, 2019 | December 2019 | |
| NCT02430584 | Unknown status | Whole Blood Specimen Collection From Pregnant Subjects | March 2015 | May 2021 | |
| NCT04791124 | Unknown status | Assessment of Neural Oscillations in Adult Subjects With Down Syndrome and Typically Developing Subjects in Resting State and While Conducting Cognitive Tasks | January 11, 2021 | June 1, 2021 | |
| NCT03188107 | Unknown status | Interrater Reliability of Infant Motor Profile | August 2016 | February 2018 | |
| NCT03206957 | Unknown status | N/A | Correlation Between Optic Nerve Vessel Anomalies, Serum Angiogenic Factors and Renal Anomalies in Down Syndrome Children | November 30, 2017 | June 1, 2019 |
| NCT00966017 | Unknown status | Glucose Metabolic, Amyloid, and Tau Brain Imaging in Down Syndrome and Dementia | July 2009 | February 2014 | |
| NCT01663675 | Unknown status | Trisomy 21 in Adulthood | November 2014 | October 2019 | |
| NCT05330741 | Unknown status | N/A | Whole-Body Vibration Versus Gravity Force Stimulation on Postural Stability in Children With Down Syndrome | April 9, 2022 | July 9, 2022 |
| NCT00965835 | Unknown status | Amyloid Plaque and Tangle Imaging in Alzheimer's Disease and Down Syndrome | August 2009 | May 2011 | |
| NCT00954382 | Unknown status | Trends in Intellectual Development in Down Syndrome | May 2009 | December 2010 | |
| NCT04241042 | Unknown status | Clinical Validation of the Bordeaux Maze Test | April 5, 2019 | April 2020 | |
| NCT03508583 | Unknown status | Turkish Version of The Measure of Processes of Care (MPOC) | May 1, 2018 | August 1, 2019 | |
| NCT01975545 | Unknown status | Phase 2 | Fluor Varnish With Silver Nanoparticles for Dental Remineralization in Patients With Trisomy 21 | September 2012 | May 2014 |
| NCT00006445 | Unknown status | N/A | Down Syndrome - Comparison of Screening Methods in the 1st and 2nd Trimesters | ||
| NCT04022460 | Unknown status | Using Personal Mobile Technology to Identify Obstructive Sleep Apnea in Children With Down Syndrome (UPLOAD) | September 17, 2019 | March 2023 | |
| NCT05145348 | Unknown status | Prospective Monitoring of Antibody Response Following COVID-19 Vaccination in Patients With Down Syndrome. | February 3, 2021 | June 30, 2023 | |
| NCT00056329 | Unknown status | Phase 3 | Vitamin E in Aging Persons With Down Syndrome | April 2002 | May 2012 |
| NCT05152251 | Unknown status | Activities and Participation of Children With Down Syndrome | February 1, 2021 | November 1, 2022 | |
| NCT02317965 | Unknown status | Non-Invasive Screening for Fetal Aneuploidy | March 2015 | November 2018 | |
| NCT03602378 | Unknown status | QoL and Stress in Parents of Children With Developmental Disabilities and Chronic Disease | April 2, 2018 | May 2, 2021 | |
| NCT00952354 | Unknown status | Oral Language in Children With Down Syndrome | August 2007 | August 2009 | |
| NCT03087500 | Withdrawn | Physiological Abnormalities Associated With Down Syndrome | October 2017 | December 2019 | |
| NCT00891917 | Withdrawn | Phase 2 | Liq-NOL Efficacy in Pediatric Patients With Down Syndrome | January 2005 | December 2012 |
| NCT04373616 | Withdrawn | Phase 2 | A Study of ACI-24 in Adults With Down Syndrome | October 2021 | October 2024 |
- Disase is a (Disease Ontology)
- DOID:0080014
- Cross Reference ID (Disease Ontology)
- GARD:10247
- Cross Reference ID (Disease Ontology)
- ICD10CM:Q90
- Cross Reference ID (Disease Ontology)
- ICD9CM:758.0
- Cross Reference ID (Disease Ontology)
- MESH:D004314
- Cross Reference ID (Disease Ontology)
- MIM:190685
- Cross Reference ID (Disease Ontology)
- NCI:C2993
- Cross Reference ID (Disease Ontology)
- ORDO:870
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:41040004
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0013080
- Exact Synonym (Disease Ontology)
- Complete trisomy 21 syndrome
- Exact Synonym (Disease Ontology)
- Down's syndrome
- Exact Synonym (Disease Ontology)
- Down's syndrome - trisomy 21
- Exact Synonym (Disease Ontology)
- Downs syndrome
- Exact Synonym (Disease Ontology)
- G Trisomy
- Exact Synonym (Disease Ontology)
- trisomy 21 syndrome
- OrphaNumber from OrphaNet (Orphanet)
- 870
- ICD10 preferred id (Insert disease from ICD10)
- D0014158
- ICD10 class code (Insert disease from ICD10)
- Q90
- MeSH unique ID (MeSH (Medical Subject Headings))
- D004314