Liver failure
Information
- Disease name
- Liver failure
- Disease ID
- Description
Disease area statistics
Chromosome band
| Gene symbol | Chromosome | Start | Stop | The number of variant |
|---|---|---|---|---|
| BOLA3 | 2 | 74,135,400 | 74,147,912 | 4 |
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT06366048 | Active, not recruiting | A Study on Relationship Between Resected Normal Liver Parenchymal Volume（RNLV）and Post-Hepatectomy Liver Failure (PHLF) | December 1, 2022 | December 31, 2024 | |
| NCT05480787 | Active, not recruiting | Phase 4 | Pharmacokinetic Study of Continuous Infusion of Remazolam in Mechanically Ventilated Patients in ICU | February 1, 2022 | September 1, 2022 |
| NCT01366144 | Active, not recruiting | Phase 1 | Veliparib, Paclitaxel, and Carboplatin in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery and Liver or Kidney Dysfunction | June 20, 2011 | March 5, 2025 |
| NCT02818218 | Active, not recruiting | SVC and Its Relationship to CVP Measurements in Liver Transplantation | July 1, 2016 | June 2024 | |
| NCT03992898 | Completed | Nomogram Analysis for HBV Related Acute-on-chronic Liver Failure | January 1, 2019 | November 1, 2019 | |
| NCT00522730 | Completed | Phase 4 | Safety and Tolerance on Lipids of Parenteral and Enteral Nutrition in Critically Ill Patients With Liver Failure | August 2007 | August 2009 |
| NCT00608244 | Completed | Phase 2 | Pharmacokinetics of LCP-Tacro in Stable Liver Transplant Patients | November 2007 | June 2008 |
| NCT00614146 | Completed | N/A | Recompensation of Exacerbated Liver Insufficiency With Hyperbilirubinemia and/or Encephalopathy and/or Renal Failure | April 2003 | April 2009 |
| NCT00772148 | Completed | Phase 2 | Pharmacokinetics of LCP-Tacro™ Once Daily and Prograf® Twice A Day in Adult De Novo Liver Transplant Patients | October 2008 | May 2010 |
| NCT00808691 | Completed | Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit | September 2007 | July 2011 | |
| NCT04237246 | Completed | Phase 4 | Comparative FK506 Drug Levels of Once Daily Advagraf in First Nations and Caucasian Patients With Liver Transplants | April 2015 | November 27, 2019 |
| NCT03833297 | Completed | Monitoring the HePAtological TOXicity of Drugs (HePATOX) | February 4, 2019 | April 4, 2023 | |
| NCT03864497 | Completed | Myocardial Perfusion Imaging in Liver Transplantation Candidates | September 2007 | June 2019 | |
| NCT03878329 | Completed | N/A | Telemedicine Based Remote Home Monitoring After Liver Transplantation | January 1, 2017 | December 1, 2020 |
| NCT04789213 | Completed | Mortality, Morbidity and Risk Factors of Liver Retransplantation | March 10, 2021 | May 1, 2021 | |
| NCT00407004 | Completed | N/A | Elimination of Albumin-Bound Substances by MARS and Prometheus | March 2003 | April 2004 |
| NCT04732689 | Completed | Intraoperative Hemodynamic Management and Postoperative Outcomes in Liver Transplantation | June 16, 2021 | July 31, 2023 | |
| NCT02455115 | Completed | N/A | Renal Perfusion, Filtration and Oxygenation After Liver Transplantation -Effects of av Postoperative Blood Pressure | January 2015 | February 2016 |
| NCT02544113 | Completed | Phase 2 | A Randomized Controlled Clinical Trial of Thymoglobulin® After Liver Transplantation | December 2015 | January 3, 2020 |
| NCT04618692 | Completed | N/A | Biliary Anastomosis Using Surgical Loupe Versus Microscope in Living Donor Liver Transplantation | December 2, 2020 | March 30, 2023 |
| NCT02557724 | Completed | Mobilization of Mesenchymal Stem Cells During Liver Transplantation | September 2015 | July 2017 | |
| NCT02584283 | Completed | Phase 3 | Dual Hypothermic Oxygenated Perfusion of DCD Liver Grafts in Preventing Biliary Complications After Transplantation | January 2016 | January 2020 |
| NCT02635347 | Completed | N/A | Remote Ischemic Conditioning (RIC) in Recipients of Brain Death Donor Livers - A Feasibility and Safety Study | November 2015 | December 31, 2017 |
| NCT04574050 | Completed | N/A | SELF-BREATHE RCT for Chronic Breathlessness | January 11, 2021 | January 30, 2022 |
| NCT02846441 | Completed | Interstage Assessment of Remnant Liver Function in ALPPS | July 2011 | June 2016 | |
| NCT03044639 | Completed | Phase 4 | Parenteral Lipid Emulsions and the Liver Function | April 1, 2010 | December 31, 2016 |
| NCT03082885 | Completed | N/A | The Efficacy and Safety of Thymosin-α1 in Patients With HBV-related ACLF | April 10, 2017 | July 30, 2019 |
| NCT00420134 | Completed | Phase 1/Phase 2 | Improvement of Liver Function in Liver Cirrhosis Patients After Autologous Mesenchymal Stem Cell Injection:a Phase I-II Clinical Trial | February 2006 | June 2009 |
| NCT04351880 | Completed | N/A | Meals MATTER: A Trial of Medically Tailored Meals 2 Weeks vs. 4 Weeks Post Hospital Discharge | April 16, 2020 | December 31, 2021 |
| NCT04347902 | Completed | Phase 4 | Lipid Emulsions and Liver Function - Results After 5 Years. | January 2016 | April 2020 |
| NCT03650920 | Completed | N/A | Hepatitis C Virus (HCV) Positive Liver Grafts in HCV Negative Recipients | September 2, 2018 | February 19, 2021 |
| NCT03667157 | Completed | Phase 4 | Liver Function After Intravenous Methylprednisolone Administration | January 1, 2012 | October 30, 2016 |
| NCT03723317 | Completed | Associated Balance of Risk Score - Comprehensive Complication Index for the Prediction of Post-transplant Survival | January 15, 2018 | October 15, 2018 | |
| NCT00886262 | Completed | N/A | Study to Evaluate if the Drug Vasopressin Protects the Kidneys for Patients Undergoing Liver Transplant | July 2007 | August 2011 |
| NCT00287235 | Completed | N/A | Efficacy of Albumin Dialysis to Treat Patients With Hepatic Encephalopathy Using The Molecular Adsorbent Recirculating System (MARS) | September 2000 | April 2004 |
| NCT00956891 | Completed | Therapeutic Effects of Liver Failure Patients Caused by Chronic Hepatitis B After Autologous MSCs Transplantation | May 2005 | July 2010 | |
| NCT01022476 | Completed | Phase 1/Phase 2 | Raltegravir in Patients With End Stage Liver Disease and in Transplant Recipients | May 2010 | May 2013 |
| NCT01081197 | Completed | Somatic Disease Among Alcohol Abusers in an Out-day Patients' Clinic | March 2010 | May 2013 | |
| NCT01160978 | Completed | Phase 2/Phase 3 | Donor Simvastatin Treatment in Organ Transplantation | June 1, 2010 | August 1, 2016 |
| NCT01201720 | Completed | N/A | Effects on Plasma Exchange on Functional Capacity of Serum Albumin, Circulatory Dysfunction, Renal and Cerebral Function in Cirrhotic Patients With "Acute-on-chronic Liver Failure" | March 2011 | February 2013 |
| NCT05958420 | Completed | Evaluation of HDL Subfraction Changes and HDL-Associated Enzymes in Liver Failure Patients and Healthy Donors | January 1, 2020 | January 15, 2022 | |
| NCT01254994 | Completed | Phase 2 | The Efficacy and Safety of Entecavir Treatment of Patients With Acute on Chronic Hepatitis B Liver Failure | August 2007 | December 2010 |
| NCT01394497 | Completed | Phase 2 | Use of N-Acetylcysteine During Liver Procurement | December 2006 | July 2009 |
| NCT01404793 | Completed | SPME For Metabolomics And Concomitant Measurements Of Rocuronium Bromide Levels In Liver Transplantation | September 2011 | April 2015 | |
| NCT01425385 | Completed | Autoregulation Assessment During Liver Transplantation | September 2011 | September 2012 | |
| NCT01429038 | Completed | Phase 1/Phase 2 | Mesenchymal Stem Cells After Renal or Liver Transplantation | February 1, 2012 | March 11, 2019 |
| NCT00325611 | Completed | N/A | Multidisciplinary Inpatient Palliative Care Intervention | April 2002 | July 2004 |
| NCT05592106 | Completed | Gd-EOB-DTPA-enhanced T1 Map for Predicting Postoperative Liver Failure | October 10, 2021 | October 13, 2022 | |
| NCT01774617 | Completed | Comparative Analysis of Different Tests to Evaluate Prognosis of Patients on Liver Transplant Waiting List | December 2015 | November 2018 | |
| NCT01785082 | Completed | Phase 3 | Fast-track LiveR: Study for the Early Identification of Low-risk Patients After Partial Liver Resection by the LiMAx-test | January 2013 | September 2015 |
| NCT00162552 | Completed | Phase 3 | Clinical Trial of Pentoxifylline in Patient With Cirrhosis | August 2004 | December 2007 |
| NCT02041637 | Completed | Unknown Cause of Acute Liver Failure | June 2013 | January 2017 | |
| NCT05045794 | Completed | N/A | Bridge to HOPE: Hypothermic Oxygenated Perfusion Versus Cold Storage Prior to Liver Transplantation | December 16, 2021 | June 10, 2024 |
| NCT02318836 | Completed | Phase 1 | Single-Dose Pharmacokinetics and Safety of Oral Lofexidine in Hepatically-Impaired Subjects | June 2014 | October 2014 |
| NCT00832273 | No longer available | Use of the ELAD® in Patients With Liver Failure to Provide Expanded Access With Cost Recovery | |||
| NCT06181318 | Not yet recruiting | Quantitative MRI and Outcomes of Liver Resection | February 1, 2024 | April 30, 2025 | |
| NCT06014320 | Not yet recruiting | Alterations in Coagulation Factor Levels in Patients With End Stage Liver Disease | October 1, 2023 | October 1, 2024 | |
| NCT06272071 | Not yet recruiting | A Multicenter Prospective Clinical Cohort Study on the Pathogen Spectrum of Severe Hepatitis (Liver Failure) Complicated With Infection | March 2024 | November 2026 | |
| NCT03640728 | Recruiting | The Efficacy and Safety of Nucleos(t)Ide Analogues in the Treatment of HBV-related Acute-on-chronic Liver Failure | January 25, 2019 | July 2023 | |
| NCT04548596 | Recruiting | NOninVasive Intracranial prEssure From Transcranial doppLer Ultrasound Development of a Comprehensive Database of Multimodality Monitoring Signals for Brain-Injured Patients | September 10, 2014 | May 30, 2024 | |
| NCT05517668 | Recruiting | Phase 2 | Evaluation of the Efficacy of Fomepizole in the Treatment of Acetaminophen Overdose | September 12, 2022 | November 30, 2025 |
| NCT05234190 | Recruiting | Phase 1/Phase 2 | Safety and Clinical Activity of QEL-001 in A2-mismatch Liver Transplant Patients | January 21, 2022 | March 2040 |
| NCT05484908 | Recruiting | N/A | Efficacy and Safety of ALSS Treatment for ICIs-LF in Patients With HCC | August 12, 2022 | August 31, 2024 |
| NCT05726032 | Recruiting | Phase 2 | Empagliflozin in Patients With Cirrhosis and Ascites | September 11, 2023 | September 1, 2025 |
| NCT05989958 | Recruiting | Phase 1 | The Safety and Tolerability Study of HepaCure in Chinese Subjects With Acute-On-Chronic Liver Failure | September 22, 2023 | September 2024 |
| NCT04617522 | Recruiting | Phase 1 | Study of Sacituzumab Govitecan in Participants With Advanced or Metastatic Solid Tumor and Moderate Liver Impairment | April 6, 2021 | November 2023 |
| NCT06300372 | Recruiting | N/A | Modified Thoracoabdominal Nerve Plane Block In Living Liver Donors | April 1, 2024 | August 1, 2024 |
| NCT05744635 | Recruiting | Assessment of the Pharmacokinetic Profile of Tacrolimus Medications and Their Relation to Effectiveness and Safety in Liver Transplant Patients | May 10, 2023 | June 1, 2026 | |
| NCT05740696 | Recruiting | Registry Study for Optimal Management of Liver Failure in the Chinese Population | January 6, 2023 | December 30, 2028 | |
| NCT06224023 | Recruiting | Predictive Values of Presepsin Levels in ASciteS in Patients With Chronic Liver Failure | May 6, 2024 | June 2024 | |
| NCT05441150 | Recruiting | Phase 4 | Intravenous Ketamine Infusion on Postoperative Analgesia of Living Liver Donors | June 1, 2022 | November 1, 2022 |
| NCT04447911 | Recruiting | Phase 4 | Effects of the SGLT2 Inhibitor Empagliflozin in Patients With Euvolemic and Hypervolemic Hyponatremia | February 4, 2021 | February 2025 |
| NCT05170971 | Recruiting | N/A | Fecal Microbiota Transplantation for Liver Failure | May 1, 2021 | December 31, 2026 |
| NCT01921985 | Terminated | Phase 2 | Terlipressin Administration in Patients Undergoing Major Liver Resection | November 2013 | March 2018 |
| NCT00915681 | Terminated | Phase 2 | Intravenous Milk Thistle (Silibinin-Legalon) for Hepatic Failure Induced by Amatoxin/Amanita Mushroom Poisoning | November 10, 2009 | April 10, 2020 |
| NCT01575015 | Terminated | N/A | Intraoperative Dialysis in Liver Transplantation | May 2012 | December 11, 2015 |
| NCT02343016 | Terminated | NIRS as a Continuous Noninvasive Monitoring System of Liver/Kidney Graft Perfusion | February 2015 | June 2015 | |
| NCT03265249 | Terminated | N/A | BRIDGE Device for Post-operative Pain Control | February 12, 2018 | April 3, 2020 |
| NCT04160039 | Terminated | N/A | Early Cycle Ergometry for Critically-Ill Liver Failure Patients in a Transplant Intensive Care Unit | November 10, 2019 | September 1, 2022 |
| NCT04107324 | Unknown status | N/A | ARAPS Study on Accelerated Liver Regeneration | January 1, 2020 | May 1, 2023 |
| NCT04116242 | Unknown status | MERTK Signalling in Monocytes/Macrophages in Patients With Liver Disease | August 27, 2015 | December 2022 | |
| NCT04122027 | Unknown status | N/A | A Prospective Randomized Controlled Trial on the Use of Cerebral Oximetry in Adult Chinese Patients Undergoing Liver Transplantation | July 30, 2018 | May 31, 2020 |
| NCT04139473 | Unknown status | N/A | Randomized Trial of Hepaticojejunostomy Versus Duct-to-duct Anastomosis in Right Lobe Living Donor Liver Transplantation | May 15, 2012 | December 31, 2022 |
| NCT00623662 | Unknown status | N/A | Preoperative Glucose Infusion: a Novel Strategy to Improve Liver Function After Liver Resection | February 2008 | March 2019 |
| NCT04221672 | Unknown status | Phase 3 | The Effect of Terlipressin on Recovery of Liver Function After Hepatectomy | November 7, 2019 | December 30, 2020 |
| NCT03791190 | Unknown status | N/A | RCA for CRRT in Liver Failure and High Risk Bleeding Patients | September 6, 2018 | August 30, 2021 |
| NCT03589820 | Unknown status | N/A | Plasma Exchange and Continuous Hemodiafiltration in Treatment of Wilson's Disease-related Liver Failure | June 1, 2018 | July 31, 2020 |
| NCT03285867 | Unknown status | Liver Stiffness Measurement (LSM) in Predicting Progress of Liver Fibrosis After TACE for Hepatocellular Carcinoma | June 25, 2018 | December 2021 | |
| NCT03000621 | Unknown status | Comparative Study of Circulating microRNA Changes in Patients With Liver Injury and Healthy Subjects | December 2016 | December 2019 | |
| NCT02882347 | Unknown status | Phase 3 | The Effect of Somatostatin for Treatment of Post Hepatectomy Liver Failure (PHLF) | July 2015 | |
| NCT01221454 | Unknown status | Phase 2 | Allogenic Bone Marrow Stem Cell Transplantation in Liver Failure | October 2010 | November 2011 |
| NCT01218464 | Unknown status | Phase 1/Phase 2 | Safety and Efficacy of Human Mesenchymal Stem Cells for Treatment of Liver Failure | March 2009 | March 2014 |
| NCT00823758 | Unknown status | Understanding Patient's Knowledge and Use of Acetaminophen | December 19, 2008 | December 1, 2020 | |
| NCT00772252 | Unknown status | Oxidative Stress and Microcirculation in Patient With Hepatic Failure Undergoing Liver Support Treatment | August 2008 | December 2010 | |
| NCT00695617 | Unknown status | Phase 2/Phase 3 | Citrate Anticoagulation During MARS Treatment | July 2008 | December 2009 |
| NCT02812121 | Unknown status | Phase 2 | UC-MSC Infusion for HBV-Related Acute-on-Chronic Liver Failure | June 2016 | June 2018 |
| NCT04705194 | Unknown status | Hepatectomy Risk Assessment With Functional Magnetic Resonance Imaging | July 8, 2019 | June 1, 2022 | |
| NCT02390713 | Unknown status | Phase 1/Phase 2 | Pneumatic Reversible Portal Vein Diameter Modulation After Major Hepatectomy | April 18, 2015 | December 2020 |
| NCT02331745 | Unknown status | Phase 4 | RCT Study on Granulocyte Colony-stimulating Factor(G-CSF) Treatment of Hepatic Failure | October 2013 | October 2016 |
| NCT04906083 | Unknown status | Phase 4 | Avatrombopag in Patients With End-stage Liver Disease and Thrombocytopenia | February 1, 2021 | December 31, 2022 |
| NCT02307890 | Unknown status | The Relationship of Initial Liver Profile and Outcome After Transplantation | August 2014 | August 2020 | |
| NCT01961440 | Unknown status | Prognosis Scoring System for Acute-on-Chronic Liver Failure | October 2013 | ||
| NCT01895114 | Unknown status | Assessment of Renal Function in Cirrhotic Patients | December 2010 | December 2015 | |
| NCT01844063 | Unknown status | Phase 1/Phase 2 | Safety and Efficacy of Diverse Mesenchymal Stem Cells Transplantation for Liver Failure | July 2013 | January 2019 |
| NCT01724398 | Unknown status | Phase 1/Phase 2 | Umbilical Cord Mesenchymal Stem Cells Transplantation Combined With Plasma Exchange for Patients With Liver Failure | November 2012 | March 2015 |
| NCT01709565 | Unknown status | Lactate Clearance According to the Presence of Hepatic Dysfunction | July 2012 | June 2014 | |
| NCT01698723 | Unknown status | Phase 2 | A Trial of Ribavirin in Patients With ACLF Due to Hepatitis E Virus | September 2012 | June 2016 |
| NCT01597102 | Unknown status | Cerebrovascular Autoregulation During and After Liver Transplantation | January 8, 2012 | March 31, 2021 | |
| NCT01423708 | Unknown status | Phase 2 | Everolimus in de Novo Liver Transplantation: a Multicentre Randomized Study | February 2010 | January 2014 |
| NCT01344174 | Unknown status | N/A | A Study Evaluating the Efficacy of Glucocorticoids in Patients With Pre-ACLF-HBV | May 2011 | November 2013 |
| NCT01322906 | Unknown status | Phase 2 | Allogeneic Bone Marrow Mesenchymal Stem Cells Transplantation in Patients With Liver Failure Caused by Hepatitis B Virus (HBV) | March 2011 | July 2012 |
| NCT02837939 | Withdrawn | Phase 2/Phase 3 | Transfer Factor Efficacy in the Management of Cirrhosis-associated Immune Dysfunction | July 2016 | July 2025 |
| NCT01137591 | Withdrawn | N/A | Acetaminophen in Combination With N-Acetylcysteine (NAC) Versus Placebo in Treating Fever | April 2009 | |
| NCT02552901 | Withdrawn | Phase 3 | Cardiox Liver Function Test Pivotal Trial | November 2015 | May 2016 |
| NCT03908255 | Withdrawn | Phase 2 | Branched-chain Amino Acid Supplementation for Hepatocellular Carcinoma | June 1, 2021 | December 30, 2023 |
| NCT00805610 | Withdrawn | Phase 1/Phase 2 | Hepatocyte Transplantation in Liver Failure | June 2014 | June 2018 |
- MeSH unique ID (MeSH (Medical Subject Headings))
- D017093