Non-small cell lung carcinoma
Information
- Disease name
- Non-small cell lung carcinoma
- Disease ID
- Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT01279408 | Active, not recruiting | Observing Patients With Palliative Asymptomatic Centrally Located Advanced Non-small Cell Lung Carcinoma (NSCLC) | November 2010 | November 2028 | |
| NCT03678350 | Active, not recruiting | Phase 1 | Light Dosimetry for Photodynamic Therapy With Porfimer Sodium in Treating Participants With Malignant Mesothelioma or Non-Small Cell Lung Cancer With Pleural Disease Undergoing Surgery | September 17, 2021 | November 13, 2025 |
| NCT04984811 | Active, not recruiting | Phase 2 | NT-I7 in Combination With Atezolizumab in Previously Untreated, PD-L1-expressing, Locally Advanced or Metastatic NSCLC | November 3, 2021 | March 2025 |
| NCT02818920 | Active, not recruiting | Phase 2 | Neoadjuvant Pembrolizumab | January 2017 | March 2026 |
| NCT02009449 | Active, not recruiting | Phase 1 | A Phase 1 Study of Pegilodecakin (LY3500518) in Participants With Advanced Solid Tumors | November 15, 2013 | August 25, 2024 |
| NCT03731585 | Active, not recruiting | N/A | Online Psychosocial Intervention in Improving Social Well-Being and Support in Women With Stage I-IV Non-small Cell Lung Cancer Undergoing Treatment | November 15, 2018 | September 30, 2025 |
| NCT02432963 | Active, not recruiting | Phase 1 | Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy | June 14, 2016 | December 31, 2024 |
| NCT03752398 | Active, not recruiting | Phase 1 | A Study of XmAb®23104 in Subjects With Selected Advanced Solid Tumors (DUET-3) | May 1, 2019 | September 2025 |
| NCT02186847 | Active, not recruiting | Phase 2 | Chemotherapy and Radiation Therapy With or Without Metformin Hydrochloride in Treating Patients With Stage III Non-small Cell Lung Cancer | August 2014 | April 16, 2025 |
| NCT03517488 | Completed | Phase 1 | A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors | July 10, 2018 | September 6, 2022 |
| NCT00086333 | Completed | Phase 2 | FDG-PET to Investigate SGN-15 and Docetaxel in Patients With Advanced Non-Small Cell Lung Carcinoma | July 2004 | December 2005 |
| NCT00213798 | Completed | N/A | Detection of Plasma DNA in Non Small Cell and Small Cell Lung Cancer Patients | December 2003 | August 2011 |
| NCT00328588 | Completed | Phase 2 | LUCY: A Study for the Treatment of Non-Small Cell Lung Cancer (NSCLC) in Patients Previously Treated With Chemotherapy | December 2006 | March 2007 |
| NCT00540514 | Completed | Phase 3 | Albumin-bound Paclitaxel (ABI-007) for Patients With Advanced Non-Small Cell Lung Cancer | November 1, 2007 | February 1, 2013 |
| NCT00753415 | Completed | Phase 1 | A Study of V934/V935 Vaccine in Cancer Participants With Selected Solid Tumors (V934-002) | August 2008 | April 2011 |
| NCT01648517 | Completed | Phase 2 | Genotype-Driven Treatment of Advanced Non-small Cell Lung Cancer Based on mRNA Expression of ERCC1 & RRM1 as First-line Chemotherapy | July 27, 2012 | June 30, 2015 |
| NCT02039674 | Completed | Phase 1/Phase 2 | A Study of Pembrolizumab (MK-3475) in Combination With Chemotherapy or Immunotherapy in Participants With Non-small Cell Lung Cancer (MK-3475-021/KEYNOTE-021) | February 21, 2014 | October 18, 2021 |
| NCT02142738 | Completed | Phase 3 | Study of Pembrolizumab (MK-3475) Compared to Platinum-Based Chemotherapies in Participants With Metastatic Non-Small Cell Lung Cancer (MK-3475-024/KEYNOTE-024) | August 25, 2014 | May 27, 2021 |
| NCT02394548 | Completed | N/A | Phase I Trial Of IMRT Using A Contralateral Esophagus Sparing Technique (CEST) In Locally Advanced Lung Cancer | June 2015 | March 2021 |
| NCT02664792 | Completed | N/A | Use of [18]F-FDG on PET/CT as an Alternative Non-invasive Method for Staging of Lung Cancer | August 2014 | December 2016 |
| NCT02689050 | Completed | Optical Biopsy for Thoracic Lymph Nodes. | January 13, 2016 | March 22, 2017 | |
| NCT02693080 | Completed | Phase 1 | CT Perfusion Imaging in Predicting Treatment Response in Patients With Non-small Cell Lung Cancer or Lung Metastases Treated With Stereotactic Ablative Radiation Therapy | January 19, 2016 | April 29, 2020 |
| NCT02758054 | Completed | N/A | Patient Navigation for Lung Cancer Screening in an Urban Safety-Net System | June 16, 2017 | February 28, 2020 |
| NCT02795156 | Completed | Phase 2 | Study Assessing Activity of Molecularly Matched Targeted Therapies in Select Tumor Types Based on Genomic Alterations | September 28, 2016 | August 17, 2022 |
| NCT02848872 | Completed | Evaluation of Tumor and Blood Immune Biomarkers in Resected Non-small Cell Lung Cancer | May 2016 | April 2, 2019 | |
| NCT02922777 | Completed | Phase 1 | Trial of Dose Escalated BGB324 in Previously Treated Non-small Cell Lung Cancer. | November 2016 | April 4, 2023 |
| NCT03141957 | Completed | Hypermetabolism in the Elderly Lung Cancer Patient | January 2016 | November 2016 | |
| NCT00081315 | Completed | Phase 2 | Subcutaneous Amifostine (Ethyol®) in the Prevention of Radiochemotherapy-Induced Esophagitis and Pneumonitis in Patients With Unresectable Non-Small Cell Lung Cancer | November 2003 | August 2006 |
| NCT03590054 | Completed | Phase 1 | Abexinostat in Combination With Pembrolizumab in Patients With Advanced Solid Tumor Malignancies | August 20, 2018 | November 30, 2023 |
| NCT03849469 | Completed | Phase 1 | A Study of XmAb®22841 Monotherapy & in Combination w/ Pembrolizumab in Subjects w/ Selected Advanced Solid Tumors | May 29, 2019 | February 16, 2023 |
| NCT06282991 | Completed | A Study to Learn About Lorlatinib in Patients With Non-Small Cell Lung Cancer Which Could Not Be Controlled | July 22, 2020 | January 18, 2021 | |
| NCT04762459 | Enrolling by invitation | Phase 3 | Efficacy and Safety of Almonertinib Combined With or Without Chemotherapy as an Adjuvant Treatment for Stage II-IIIA Non-small Cell Lung Carcinoma Following Complete Tumour Resection | August 1, 2021 | May 2029 |
| NCT03554434 | No longer available | An Expanded Access Program for AM0010 (Pegilodecakin) | |||
| NCT04853342 | Not yet recruiting | Phase 3 | To Assess the Efficacy and Safety of Furmonertinib Versus Placebo, in Patients With Epidermal Growth Factor Receptor Mutation Positive Stage II-IIIA Non-small Cell Lung Carcinoma, Following Complete Tumour Resection With or Without Adjuvant Chemotherapy | April 17, 2021 | January 2025 |
| NCT05393466 | Not yet recruiting | Phase 1/Phase 2 | BPI-361175 Tablets in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) | July 1, 2023 | May 31, 2027 |
| NCT06222489 | Not yet recruiting | Phase 2 | Whole Body HER3 Quantification With Radiolabelled Patritumab Deruxtecan (HER3-DXd) PET/CT | May 1, 2024 | May 1, 2028 |
| NCT05358249 | Recruiting | Phase 1/Phase 2 | Platform Study of JDQ443 in Combinations in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation | October 24, 2022 | June 16, 2027 |
| NCT05642195 | Recruiting | Phase 1/Phase 2 | Evaluation of a Cancer Lysate Vaccine and Montanide (Registered Trademark) ISA-51 VG With or Without the IL-15 Super-Agonist N-803 as Adjuvant Therapy for PD-L1 Negative Non-Small Cell Lung Cancer | June 23, 2024 | December 30, 2035 |
| NCT03735095 | Recruiting | Phase 1/Phase 2 | Endobronchial Ultrasound Guided Interstitial Photodynamic Therapy in Treating Patients With Locally Advanced Lung Cancer | February 12, 2020 | February 12, 2030 |
| NCT06270082 | Recruiting | Phase 1 | Study of IK-595 in RAS- or RAF-altered Advanced Tumors | December 18, 2023 | July 2027 |
| NCT04042701 | Recruiting | Phase 1 | DS8201a and Pembrolizumab in Participants With Locally Advanced/Metastatic Breast or Non-Small Cell Lung Cancer | February 10, 2020 | August 1, 2025 |
| NCT05110196 | Recruiting | Phase 4 | Study of Capmatinib in Indian Patients With MET Exon 14 Skipping Mutation Positive Advanced NSCLC. | September 3, 2022 | June 30, 2025 |
| NCT00633568 | Terminated | Phase 3 | Randomised Study of Concomitant Radiochemotherapy in Non-small Cell Lung Cancer | January 2007 | February 2015 |
| NCT00365183 | Terminated | Phase 2 | Trial of Motexafin Gadolinium and Pemetrexed (Alimta®) for Second Line Treatment in Patients With Non-Small Cell Lung Cancer | June 2006 | June 2008 |
| NCT01915524 | Terminated | Phase 1 | Trial of RNActive®-Derived Cancer Vaccine and Local Radiation in in Stage IV Non Small Cell Lung Cancer (NSCLC) | April 2013 | July 2016 |
| NCT02062632 | Terminated | Phase 2 | Doxepin Hydrochloride in Treating Esophageal Pain in Patients With Thoracic Cancer Receiving Radiation Therapy to the Thorax With or Without Chemotherapy | April 14, 2014 | November 6, 2017 |
| NCT02556593 | Terminated | Phase 2 | IMRT Combined With Erlotinib for EGFR Wild Type Non-small Cell Lung Cancer With 4-10 Brain Metastases | September 2015 | April 2019 |
| NCT04000529 | Terminated | Phase 1 | Phase Ib Study of TNO155 in Combination With Spartalizumab or Ribociclib in Selected Malignancies | July 30, 2019 | January 15, 2024 |
| NCT03054038 | Terminated | Phase 1 | Afatinib and Necitumumab in Patients With EGFR Mutation Positive Advanced or Metastatic Non-small Cell Lung Cancer | July 20, 2017 | March 23, 2022 |
| NCT02937402 | Terminated | N/A | Bronchoscopy With Bronchoalveolar Lavage in Identifying Biomarkers of Response to Immune Checkpoint Inhibitors in Patients With Non-small Cell or Small Cell Lung Cancer | April 5, 2018 | August 20, 2019 |
| NCT01288430 | Terminated | Phase 1 | A Study of DS-2248 in Participants With Advanced Solid Tumors | March 29, 2011 | February 13, 2014 |
| NCT03957096 | Terminated | Phase 1 | A Safety Study of SGN-CD47M in Patients With Solid Tumors | July 17, 2019 | September 14, 2020 |
| NCT02224547 | Unknown status | Phase 2 | Risk-adapted Stereotactic Body Radiotherapy for Early Non-Small Cell Lung Cancer Using the VERO Stereotactic Body Radio Therapy System | January 2013 | |
| NCT02273271 | Unknown status | N/A | Evaluation of FLT-PET and DWI-MRI in Patients With NSCLC Treated With a Platinum-based Doublet as Preoperative Chemo | October 2015 | February 2017 |
| NCT02879097 | Unknown status | Phase 3 | Efficacy-Safety-Immunogenicity Study of CBT124&EU-sourced Avastin® in Stage 4 NSCLC | December 2016 | May 2018 |
| NCT00192829 | Unknown status | Hypercoagulable Parameters as Predictors of Thrombotic Events and Prognosis in Patients With Advanced Non-Small Cell Lung Carcinoma | June 2005 | ||
| NCT03713099 | Withdrawn | N/A | NEUWAVE Flexible Probe Study #2 | July 31, 2020 | March 31, 2022 |
| NCT03408561 | Withdrawn | N/A | Social Media Listening in Improving Clinical Trial Recruitment in Patients With Cancer | November 8, 2017 | December 31, 2018 |
- HPO Human Phenotype ID (Human Phenotype Ontology)
- HP:0030358