acute pancreatitis

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Information
Disease name
acute pancreatitis
Disease ID
DOID:2913
Description
"A pancreatitis that is characterized by inflammation of the pancreas over a short period of time and has symptoms of severe abdominal pain, nausea, vomiting, diarrhea, fever, and shock." [url:https\://www.nhs.uk/conditions/acute-pancreatitis/]
Disease area statistics
Chromosome band
Gene symbol Chromosome Start Stop The number of variant
FH 1 241,497,603 241,519,755 2
FANCA 16 89,737,549 89,816,647 2
RINT1 7 105,532,201 105,567,677 2
BRCA2 13 32,315,508 32,400,268 2
EFCAB10 7 105,565,233 105,581,496 2
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT04681066 Active, not recruiting Phase 2 A Study of Auxora in Patients With Acute Pancreatitis and Accompanying SIRS March 24, 2021 September 2024
NCT04989166 Active, not recruiting N/A Effect of Nano-curcumin Supplementation in Acute Pancreatitis October 19, 2021 January 15, 2023
NCT06327230 Active, not recruiting N/A The Application of Thoracic Epidural Analgesia in Patients With Acute Pancreatitis March 1, 2024 April 30, 2026
NCT03063398 Active, not recruiting Post Acute Pancreatitis Pancreatic Exocrine Insufficiency June 21, 2017 December 2024
NCT04214756 Active, not recruiting Methodist Acute Pancreatitis Protocol April 5, 2014 June 2025
NCT01017107 Completed Phase 4 Activated Protein C in Severe Acute Pancreatitis June 2003 September 2007
NCT06241586 Completed A Novel Surgical Strategy to Reduce Major Complications in Patients With Necrotizing Pancreatitis January 1, 2019 October 1, 2022
NCT01128478 Completed Phase 2/Phase 3 MIld to MOderate Acute Pancreatitis: Early naSogastric Tube Feeding Compared With pAncreas Rest (MIMOSA) May 2010 April 2012
NCT01292005 Completed Early Phase 1 Pentoxifylline Treatment of Acute Pancreatitis April 2009 July 2012
NCT01293318 Completed Study of Copeptin as a Diagnostic Marker for Acute Pancreatitis March 2011 September 2016
NCT01315613 Completed Role of ST2 in Acute Pancreatitis January 2005 September 2008
NCT01449084 Completed N/A Early Pancreatic Duct Stent Removal in Preventing Post-endoscopic Pancreatitis December 2009 June 2011
NCT01470885 Completed Relation of Glucose and Acute Pancreatitis March 2011 December 2011
NCT01503320 Completed N/A Efficacy of Enteral Glutamine Supplementation in Patients With Predicted Severe Acute Pancreatitis- A Double-Blinded Randomized Controlled Trial January 2012 December 2014
NCT01507766 Completed Phase 4 The Correlations Between Early Enteral Nutrition and Intra-abdominal Pressure in Severe Acute Pancreatitis September 2010 September 2011
NCT01527084 Completed N/A Timing of Surgical Intervention After Percutaneous Catheter Drainage in STEP UP Approach for Severe Acute Pancreatitis July 2011 December 2012
NCT01611532 Completed An Observational Study of the Role of Intra-abdominal Pressure Monitoring in Patients With Acute Pancreatitis November 2010 December 2011
NCT03456557 Completed N/A The Use of Perfusion CT Derived Parameters as Early Acute Pancreatitis Severity Biomarker Compared to Clinico Biological Score March 7, 2018 December 9, 2018
NCT04670705 Completed Relationship of CP and AP January 2010 October 2020
NCT04615702 Completed Evidence Based Management of Acute Biliary Pancreatitis May 15, 2017 May 15, 2019
NCT04525027 Completed Predictive Ability of Intra-Abdominal Pressure for Mortality in Patients With Severe Acute Pancreatitis December 26, 2019 October 20, 2021
NCT00894907 Completed N/A Early Goal-directed Volume Resuscitation in Severe Acute Pancreatitis August 1, 2009 May 30, 2020
NCT06464887 Completed A Predictive Model for Recurrent Acute Pancreatitis January 1, 2016 June 30, 2018
NCT03566173 Completed Association Between Nonalcoholic Fatty Liver Disease and Acute Pancreatitis March 10, 2018 April 15, 2018
NCT04901949 Completed The Course of Acute Pancreatitis in Patients With Different BMI Groups September 20, 2020 April 30, 2021
NCT03650062 Completed Patient-reported Outcome Scale in Acute Pancreatitis May 30, 2017 February 3, 2019
NCT04870268 Completed Late Phase Acute Pancreatitis: a Tailored Step-up Approach January 2012 January 1, 2021
NCT03694210 Completed N/A EndoRotor DEN (Direct Endoscopic Necrosectomy)Trial November 15, 2018 August 22, 2019
NCT03709342 Completed Phase 2 A PK/PD Study of CM4620-IE in Patients With Acute Pancreatitis January 6, 2019 June 7, 2019
NCT04796311 Completed Imunomodulation in Acute Pancreatitis February 26, 2021 December 30, 2023
NCT04777812 Completed N/A Pancreatitis - Microbiome As Predictor of Severity February 17, 2020 February 23, 2024
NCT04743570 Completed Phase 2/Phase 3 Effects of Peripherally Acting µ-opioid Receptor Antagonists on Acute Pancreatitis May 14, 2021 April 20, 2023
NCT04735055 Completed Artificial Intelligence Prediction for the Severity of Acute Pancreatitis September 3, 2020 September 30, 2020
NCT00786591 Completed Study of New Biological Markers for Prediction of Severe Acute Pancreatitis June 2006 July 2009
NCT04033549 Completed Thoracic Ultrasound on Acute Pancreatitis November 15, 2019 December 31, 2019
NCT04708925 Completed Hypertriglyceridemia-associated Acute Pancreatitis: Apheresis Vs. Conservative Treatment February 1, 2021 October 1, 2021
NCT01728896 Completed N/A Patient-Initiated and ConTrolled Oral Refeeding (PICTOR) December 1, 2013 June 1, 2019
NCT01796652 Completed Home Treatment of Acute Pancreatitis November 2011 June 2012
NCT01911689 Completed Magnetic Resonance Imaging Study of Acute Pancreatitis August 2013 March 2015
NCT01965873 Completed Phase 4 Enteral Nutrition in Acute Pancreatitis May 2007 June 2012
NCT01977118 Completed Phase 2/Phase 3 Use of Streptokinase for Enhancement of Percutaneous Drainage of Pancreatic Necrosis May 2013 December 2014
NCT00560157 Completed Phase 4 Nutritional and Metabolic Evaluation of a Tube Feeding Immune Enhancing Diet in ICU Patients December 2002 March 2006
NCT02111707 Completed Phase 4 Timing of Indomethacin Administration for the Prevention of Post-ERCP Pancreatitis (PEP) April 2014 September 2017
NCT05651360 Completed Diagnostic Performance of Low-Dose CT for Acute Abdominal Conditions December 7, 2022 July 10, 2023
NCT02212392 Completed Phase 1/Phase 2 Comparing the Outcome in Patients of Acute Pancreatitis, With and Without Prophylactic Antibiotics January 2013 December 2013
NCT02318134 Completed Phase 2 Fecal Microbiota Transplantation for Pancreatitis November 18, 2017 December 18, 2019
NCT02543658 Completed Phase 2 Neostigmine Treatment of Acute Pancreatitis Combined With Intra-abdominal Hypertension September 1, 2015 May 30, 2018
NCT02563080 Completed Pancreatic Exocrine Insufficiency in Acute Pancreatitis September 2015 February 2022
NCT02602808 Completed Study of Peripheral Blood Non-coding RNAs as Diagnosis and Prognosis Biomarker for Acute Pancreatitis December 2015 December 2019
NCT02622854 Completed N/A Plasma Exchange vs Conservative Management in Non-severe Acute Hypertriglyceridemic Pancreatitis June 2016 August 2020
NCT02692391 Completed Phase 3 A Randomized Controlled Pilot Trial of Indomethacin in Acute Pancreatitis July 2013 December 30, 2019
NCT02743364 Completed Phase 2 Simvastatin in Reducing Pancreatitis in Patients With Recurrent, Acute or Chronic Pancreatitis September 19, 2016 May 11, 2022
NCT02813876 Completed Phase 2 Enhanced Recovery in Acute Pancreatitis June 2016 May 15, 2017
NCT02814071 Completed N/A Early Feeding in Acute Pancreatitis in Children August 2016 April 17, 2019
NCT05201053 Completed Acute Pancreatitis and Coagulation Study May 1, 2017 June 1, 2023
NCT02897206 Completed Phase 4 Imipenem Prophylaxis in Patients With Acute Pancreatitis October 2014 December 2016
NCT02928718 Completed The Association Between Post-ERCP Acute Pancreatitis and Various Genetic Mutations September 29, 2016 July 2019
NCT03028181 Completed The Evaluation of Pro/Antioxidative Profile and Diagnostic Parameters in the Patients With Pancreatic Disease January 2014 December 2016
NCT03173222 Completed N/A Electroacupuncture for Acute Pancreatitis August 1, 2017 August 29, 2020
NCT03394378 Completed The Impact of Non-Alcoholic Fatty Pancreas Disease on Outcome of Acute Pancreatitis November 6, 2017 December 15, 2017
NCT03401190 Completed Phase 2 CM4620 Injectable Emulsion Versus Supportive Care in Patients With Acute Pancreatitis and SIRS March 12, 2018 April 30, 2019
NCT03482921 Completed Body Parameters as an Independent Predictor of Acute Pancreatitis December 1, 2017 March 22, 2018
NCT04917172 Completed Post-Operative Acute Pancreatitis After Pancreaticoduodenectomy April 10, 2019 June 30, 2021
NCT05410795 Enrolling by invitation Establishment and Verification of Pancreatic Volume Formula Based on Imaging September 5, 2022 December 2022
NCT05487833 Not yet recruiting Phase 4 Insulin and Standard Management in Hypertriglyceridemic Acute Pancreatitis November 2022 September 2024
NCT06113419 Not yet recruiting N/A Timing of CHolecystectomy In Severe PAncreatitis March 2024 December 2026
NCT06240338 Not yet recruiting Acute Pancreatitis : Comparison of Various Scores in Predicting Severity and Outcome February 20, 2024 August 20, 2025
NCT06230432 Not yet recruiting Exploring the Mechanism of Severe Acute Pancreatitis Based on Metagenomics, Metabolomics and Proteomics January 21, 2024 December 9, 2026
NCT04963868 Not yet recruiting N/A Timing of Transmural Stent Removal in Necrotizing Pancreatitis January 1, 2022 December 1, 2025
NCT05360797 Not yet recruiting N/A Acute PAncreatitis and Home Care vs. Hospital Admission Study July 1, 2022 July 31, 2024
NCT05722678 Not yet recruiting Study and Analysis of Acute Pancreatitis Complicated With COVID-19 February 15, 2023 June 12, 2023
NCT06401577 Not yet recruiting Diabetes RElated to Acute Pancreatitis and Its Mechanisms: Metabolic Outcomes Using Novel CGM Metrics July 1, 2024 March 31, 2027
NCT04990336 Not yet recruiting N/A Dachaihu Decoction Compound and Rhubarb Single Medicine in the Treatment of Acute Pancreatitis September 1, 2023 July 31, 2029
NCT06409741 Not yet recruiting N/A PrEveNtion of Biliary Events After Acute Pancreatitis In NonSUrgicaL pAtients: PENINSULA Trial July 2024 July 2027
NCT05501314 Not yet recruiting N/A Remote Home Monitoring Acute Pancreatitis October 2022 April 2025
NCT06124989 Not yet recruiting Machine learnINg for the rElapse Risk eValuation in Acute Biliary Pancreatitis. January 1, 2024 December 31, 2025
NCT06147635 Not yet recruiting Phase 2 Prophylactic Tributyrin Supplementation in Acute Pancreatitis November 2023 May 2025
NCT05859633 Recruiting Neutrophil/Lymphocyte Ratio in Acute Pancreatitis May 30, 2023 December 31, 2023
NCT03547232 Recruiting Phase 4 Rectal Indomethacin as Early Treatment for Acute Pancreatitis (INDOMAP Trial) June 1, 2024 June 1, 2030
NCT03643718 Recruiting Web-based International Register of Emergency Surgery and Trauma July 2020 September 2030
NCT03853447 Recruiting Fibro-inflammatory Progression From Acute to Chronic Pancreatitis February 14, 2019 January 1, 2041
NCT04195347 Recruiting Phase 1/Phase 2 Study of CM4620 to Reduce the Severity of Pancreatitis Due to Asparaginase September 4, 2020 December 2025
NCT04291599 Recruiting Phase 2 Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid March 15, 2022 June 30, 2024
NCT04647097 Recruiting N/A Preventing the Recurrence of Acute Pancreatitis by Alcohol and Smoking Cessation March 1, 2022 June 30, 2028
NCT04761523 Recruiting N/A The Effect of Dietary Fat Content on the Recurrence of Pancreatitis May 1, 2022 December 31, 2026
NCT04814693 Recruiting N/A Conventional Endoscopic Techniques Versus EndoRotor® System for Necrosectomy of Walled of Necrosis September 2, 2022 August 30, 2024
NCT04816877 Recruiting Use of Patient-Controlled Analgesia in Acute Pancreatitis February 1, 2022 April 30, 2024
NCT05197920 Recruiting Diabetes RElated to Acute Pancreatitis and Its Mechanisms January 14, 2022 April 30, 2025
NCT05281458 Recruiting N/A Early Versus Standard Endoscopic Interventions for Peripancreatic Fluid Collections September 15, 2021 December 2024
NCT05473260 Recruiting N/A Home Monitoring Vs. Hospitalization for Mild Acute Pancreatitis November 16, 2022 July 16, 2025
NCT05480241 Recruiting N/A Exocrine Pancreatic Insufficiency After Acute Pancreatitis and Pancreatic Enzyme Replacement Therapy May 1, 2022 December 31, 2024
NCT05613673 Recruiting Prognostic Value of Different Nutritional Screening Tools in Acute Pancreatitis October 11, 2022 March 31, 2025
NCT05637281 Recruiting N/A Clinical Efficacy of Indomethacin in Early Treatment of Acute Pancreatitis December 11, 2022 December 11, 2023
NCT05638555 Recruiting Lactated Ringers vs Normal Saline in Patients With Acute Pancreatitis: A Bias-Adjusted Meta-analysis August 15, 2023 June 1, 2024
NCT05756504 Recruiting Early Phase 1 "NSAIDs vs. Opiates: Which is More Effective in Managing Pain in Mild to Moderate Acute Pancreatitis? February 22, 2023 February 20, 2024
NCT05781243 Recruiting Phase 4 Normal Saline Versus Lactated Ringer's Solution for Acute Pancreatitis Resuscitation June 19, 2023 April 1, 2026
NCT05817721 Recruiting PROTon Pump Inhibitors and Stent OCclusion Rate Of Lumen Apposing Metal Stents May 5, 2023 December 2023
NCT05878236 Recruiting iMmune SignAtures and Clinical outComes in AP March 6, 2023 December 31, 2027
NCT06023771 Recruiting Invasive Intervention of Local Complications of Acute Pancreatitis October 2023 December 2026
NCT06077188 Recruiting N/A EFFECT OF CHEWING GUM ON CONTROLLING NAUSEA/VOMITING AND THIRST IN PATIENTS WITH ACUTE PANCREATITIS December 1, 2023 March 1, 2024
NCT06080789 Recruiting Phase 2 A Study to Evaluate the Safety and Efficacy of a Single Dose of RABI-767 in Participants With Acute Pancreatitis February 26, 2024 February 2025
NCT06179459 Recruiting Registry of Patients Undergoing Endoscopic Management of Pancreatic Fluid Collections May 1, 2021 December 2032
NCT06223594 Recruiting Evaluation of Intravenous Fluid Therapy Within Dallas Acute Pancreatitis Protocol July 17, 2023 July 17, 2024
NCT06283160 Recruiting Metabolomic and Immune Profiling in the Development of Pancreatic Fistulas After Cephalic Duodenopancreatectomy March 1, 2024 May 30, 2026
NCT04306939 Suspended Genomic Resources for Enhancing Available Therapies (GREAT1.0) Study November 1, 2014 December 1, 2025
NCT00853515 Terminated N/A Goal-directed Fluid Resuscitation in Acute Pancreatitis March 2009 June 2010
NCT03807856 Terminated Phase 1 Treating Acute Pancreatitis With Dabigatran, a Pilot Study June 24, 2019 July 23, 2020
NCT02885441 Terminated Phase 4 Treatment of Acute Pancreatitis With Ketorolac September 2016 February 1, 2019
NCT04381169 Terminated Phase 3 Aggressive Versus Non-aggressive Goal-directed Fluid Resuscitation in Acute Pancreatitis May 28, 2020 September 25, 2021
NCT01060826 Unknown status Phase 3 Efficacy of Administration of Somatostatin in the Prevention of Post-endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis May 2009 May 2012
NCT02617199 Unknown status Phase 2/Phase 3 Epidural Anesthesia in Acute Pancreatitis November 2015 February 2017
NCT02373293 Unknown status Study to Assess the Prognostic Value of the Antithrombin III in the Acute Pancreatitis (AT-PROPANC) January 18, 2015 August 31, 2017
NCT00562445 Unknown status Adrenal Insufficiency in Critical Emergencies in Digestive Diseases May 2007 May 2008
NCT02318147 Unknown status Phase 1 Fecal Microbiota Transplantation for Pancreatitis With Infectious Complications(FMTPIC) November 2016 December 2018
NCT02223325 Unknown status Evaluation of Prognosis and Prognostic Scores in Geriatric Patients With Acute Pancreatitis August 2014
NCT01626911 Unknown status N/A Continuous Regional Arterial Infusion of Low Molecular Weight Heparin in Patients With Severe Acute Pancreatitis September 2011
NCT01595672 Unknown status N/A Early High-volume Continuous Veno-venous Hemofiltration for Patients With Severe Acute Pancreatitis April 2012 March 2013
NCT02204189 Unknown status Phase 1/Phase 2 The Clinical Study of Acute Pancreatitis Treated by TongFuSan March 2014 February 2017
NCT01998334 Unknown status N/A Continuous Blood Purification for Regulation of Early Inflammatory Response In Severe Acute Pancreatitis July 2012 December 2016
NCT04552028 Unknown status Respiratory Dysfunction in Acute Pancreatitis (SAFI) December 15, 2019 January 31, 2021
NCT04553783 Unknown status Exploration of Blood Biomarkers, Including Whole Blood Viscosity as a Prognostic Factor for Acute Pancreatitis March 10, 2020 May 2023
NCT04608760 Unknown status Phase 1 Prevention of Acute Pancreatitis After Endoscopic Interventions August 1, 2020 August 1, 2021
NCT04282200 Unknown status Phase 4 Ketorolac in Acute Pancreatitis February 24, 2020 December 2022
NCT00793715 Unknown status N/A Laparotomy Versus Percutaneous Puncture in Patients With Abdominal Compartment Syndrome During Acute Pancreatitis July 2010 June 2013
NCT04222075 Unknown status Identification of the Impact of Acute Pancreatitis on Quality of Life August 26, 2018 September 1, 2022
NCT04196504 Unknown status Prevalence of Echocardioghraphic and ECG Changes in Patients With Acute Pancreatitis and Its Impact on Outcome. December 31, 2019 December 31, 2021
NCT04688645 Unknown status Phase 4 Balanced Crystalloid Solutions for Acute Pancreatitis May 1, 2020 February 1, 2023
NCT04038554 Unknown status Microbiota in Acute Pancreatitis: Prospective Multicenter Study May 1, 2020 September 1, 2020
NCT03830073 Unknown status Assessment of the Different Etiological and Susceptibility Markers in Patients With Pancreatitis: Investigating IG4, Cytomegalovirus, Coxsackie- Virus, Genetic Polymorphism of Vitamin D Receptor Gene March 1, 2019 June 20, 2019
NCT03830060 Unknown status Clinical Usefulness of Cortisol, Antinuclear Antibodies and High-sensitivity C-reactive Protein in Acute Pancreatitis February 25, 2019 May 30, 2019
NCT04747990 Unknown status coMpliAnce With evideNce-based cliniCal Guidelines in the managemenT of Acute biliaRy pancreAtitis April 1, 2021 September 1, 2021
NCT00699933 Unknown status Diagnostic and Interventional Therapy in Acute Pancreatitis May 2008 December 2012
NCT03820128 Unknown status N/A Early Nutrition in Acute Pancreatitis February 1, 2019 January 31, 2021
NCT03634787 Unknown status Heat Shock Proteins: a Pathogenic Driver and Potential Therapeutic Target in Acute Pancreatitis October 20, 2017 December 30, 2021
NCT03282253 Unknown status Elevated Stearoyl-CoA Desaturase-1 Expression Predicts the Disease Severity of Severe Acute Pancreatitis January 1, 2018 June 30, 2019
NCT03259880 Unknown status Searching the Best Prognostic Factor in Out Come Evaluation in Patients With Acute Pancreatitis Admitted at Assiut University Hospitals September 1, 2017 September 1, 2018
NCT03015467 Unknown status Phase 1/Phase 2 Fecal Microbiota Transplantation (FMT) for Severe Acute Pancreatitis(SAP) December 2016 March 2020
NCT01249963 Unknown status N/A Enteral Nutrition Product in Mild Acute Pancreatitis February 2011 March 2013
NCT03501680 Unknown status Phase 4 Intensive Insulin for Severe/Moderate Hypertriglyceridemia Pancreatitis. June 6, 2018 December 31, 2020
NCT01321060 Unknown status N/A Fluid Collections Management in Severe Acute Pancreatitis January 2011
NCT01992224 Unknown status N/A Effect of Early Mechanical Ventilation to Severe Acute Pancreatitis July 2012 June 2016
NCT03684278 Unknown status Phase 2 Randomised Treatment of Acute Pancreatitis With Infliximab: Double-blind Multi-centre Trial (RAPID-I) May 1, 2019 April 30, 2024
NCT01798511 Withdrawn N/A Oral Refeeding IntOlerance After Nasogastric Tube Feeding (ORION) April 1, 2013 April 1, 2020
Disase is a (Disease Ontology)
DOID:4989
Cross Reference ID (Disease Ontology)
ICD10CM:K85
Cross Reference ID (Disease Ontology)
ICD9CM:577.0
Cross Reference ID (Disease Ontology)
MESH:D010195
Cross Reference ID (Disease Ontology)
NCI:C95437
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:39726008
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0001339
HPO alt_id (Human Phenotype Ontology)
HP:0004512
HPO Human Phenotype ID (Human Phenotype Ontology)
HP:0001735
ICD10 preferred id (Insert disease from ICD10)
D0008911
ICD10 class code (Insert disease from ICD10)
K85